JPH0116806B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention relates to a method for producing a drug antidote for animals,
More specifically, the present invention relates to a method for producing a drug for detoxifying animals from poisoning caused by the pesticide Dimecuron, which is based on crude drugs. [Prior Art] In recent years, damage to livestock and other animals due to various pesticide poisoning accidents has been increasing. As a result, the ecology has been destroyed to a large extent.
Despite the fact that the animal resources that live around us are being affected, no fundamental measures have been found to prevent or cure this problem, and the problem has been left as it is. It's here. [Problems to be Solved by the Invention] The problem to be solved by the present invention is to provide a method for producing a drug that can quickly detoxify such drug-induced poisoning, particularly poisoning caused by the pesticide Dimeclone in animals. [Means for Solving the Problems and Their Effects] The method for producing an antidote for poisoning with the pesticide Dimecuron according to the present invention is to produce a pulverized dried product of oak leaves or bark, 70 g.
20% by weight of crushed dried juniper leaves or juniper roots, 5% by weight of tangerine peel, 2.5% by weight of kudzu roots, and 2.5% by weight of licorice.
An extraction obtained by uniformly mixing a mixture of and water at a volume ratio of 1:3, steaming this at 40 to 60°C for 5 to 6 hours, and extracting the resulting steamed liquid under reduced pressure. are also mixed with the mixture in a volume ratio of 3:1;
This was further vacuum boiled at 110℃ for 0.5 to 1.0 hours, extracted, and the extract was boiled at 110℃ for 5 to 6 hours.
This is done by boiling under vacuum for an hour, then adding 0.5% by weight of glycerin to the resulting extract and dispersing it at high speed. In Chinese medicine, oak leaves and bark are used as astringents and mordants, and juniper leaves and juniper roots are used as diuretics and antispasmodics.
Mandarin orange peel contains limonene and the glycoside hesperidion, and is used as an aromatic stomachic, digestive agent, anti-nausea and cough medicine, etc., and the root of the kuzu tree contains daidzin and It contains daidzein, a decomposition product, and puerarian, an isoflavone derivative, which has antispasmodic and carminative detoxifying effects, and is used as a sweating and antipyretic drug for febrile diseases. It is used for colds, pain relief, tonsillitis, conjunctivitis, etc. Kanzo is a type of saponin and contains glycyrrhizin, which is a sweetening ingredient, as its main ingredient, and is used as an antitussive, for diseases, as a flavor corrective, as an antidote, and as a sweetener. etc. is used. Glycerin is used as a carrier for over-the-counter preparations, emollients, enemas, suppositories, etc. In the present invention, the glycerin molecule is 800-1000 r.p.
Dispersed at high speed by m. When the antidote produced by the method of the present invention is administered orally or nasally to an animal poisoned by a drug, such as a pesticide such as BPM oil or DDVP oil (especially Dimeclone), it will be absorbed into the body through respiration. Depending on the degree of poisoning, the poison will be killed immediately or slowly, and the remaining toxicity will be removed. The pharmacological and physiological mechanisms of this detoxification have not yet been clearly elucidated, but the basic principle is that the detoxification agent produced by the method of the present invention acts strongly as an oxygen transfer reaction promoter and neutralizes toxic substances in the body. It is thought that it promotes biological reactions. Although the antidote according to the method of the present invention can be prepared in various dosage forms commonly considered in the pharmaceutical industry, it is most effective for oral and nasal administration and is therefore used as an antidote in liquid form. It is also possible. A single dose is appropriately increased or decreased depending on the degree of intoxication. [Examples and their effects] (a) Production of antidote 70g powder of sufficiently dried sawtooth leaf KL, 20g powder of juniper leaf JL, 5g powder of mandarin peel GL, 2.5g powder of Kuzu tree root CH Add water to mixture A, which is a uniform mixture of 2.5 g of powder
After adding 300 ml and heating at 50°C for about 5 hours with stirring, the resulting steamed liquid is extracted under reduced pressure. 100 g of a mixture having the same composition as Mixture A is added to 300 ml of the resulting extract, and the mixture is boiled under vacuum at 110° C. for 0.5 hour for extraction. The extract thus obtained was further vacuum boiled at 110°C for 4 hours, and the extract was continued to be vacuum boiled at 110°C for 4 hours, cooled in a cooler, and 0.5% by weight of glycerin was added to Disperse and mix at high speed at 1000rpm,
Manufacture antidote 1. (b) Manufacture of antidote Of the mixture A mentioned above, 70 g of dry powder of sawtooth bark KL was used in place of sawtooth leaf KL, and 20 g of dry powder of juniper root JP was used in place of juniper leaf JL. Mixture B is then prepared without changing the other components, and Antidote 2 is produced in the same manner as in the production of the above-mentioned Antidote. (c) Test Example In order to confirm the effectiveness of the antidote according to the method of the present invention, the following test was conducted using locust as a sample of edible freshwater fish. After poisoning a loach with a body size of 8 to 12 cm using a pesticide dimeclone solution (0.001% aqueous solution) diluted 100 times with water, mixture A and each component are manufactured according to the method of manufacturing an antidote. (1) When two of the components of mixtures A and B are added separately, (2) When two of the components of mixtures A and B are manufactured according to the method of (1) or (2) are added separately, (2) Water is added. The detoxification effects were tested when diluted with a) antidotes 1 and 2, respectively. The environmental conditions during this test were wind speeds of 0.5~
1m/sec., and the room temperature was 25-26℃. As a result, it was found that it exhibited detoxifying effects as shown in Table 1.

【table】

[Table] From this result, even if the constituent components of the mixture of the present invention are used alone or in combination, the detoxification effect is up to 60% (in the case of a single component) or 65% (in the case of a mixture of the two components). However, it was found that sufficient detoxification could not be achieved. On the other hand, both antidotes 1 and 2 produced by the method of the present invention can exhibit a detoxification effect of 95%, and the time required for the detoxification action to begin is extremely short, 2 seconds. It was found that even a small amount can have a detoxifying effect. (d) Test Example In order to confirm the detoxifying effect of the antidote according to the method of the present invention on mammals, the following test was conducted using rabbits. , 100 times diluted pesticide Dimecuron solution (0.001
% aqueous solution) was orally administered to a rabbit weighing approximately 3.5 kg, the seizure began approximately 5 minutes after administration, and detoxification occurred after approximately 20 minutes to allow the toxicity of the pesticide Dimecuron to be fully absorbed into the body. Agents 1 and 2 were orally administered at different doses,
The state of sedation of the attack due to the subsequent detoxification was visually observed. As a result, it was found that it exhibited detoxifying effects as shown in Table 2.

[Table] The patient recovered after some time.
From this result, it was found that the amount of antidote 1 and 2 administered to rabbits should be about 30 to 35 ml or more to exhibit sufficient detoxifying effect, and preferably about 50 to 55 ml or more. It was also found that there was no significant difference in the detoxification effect when the dose was about 60 to 65 ml or more. Here, when using the antidote according to the present invention, the rabbit's first sign of detoxification was attenuation of the seizures, and when the seizures were completely subdued by the detoxification, the rabbits entered a sleep state. It was also confirmed that the condition of the rabbits after coming out of the sleeping state was unchanged from before the administration of the pesticide Dimeclon. The dose of the antidote according to the present invention should be changed as appropriate depending on the degree of intoxication such as the amount of pesticide Dimecuron absorbed, the time elapsed from administration, and individual differences such as body weight and constitution, but approximately Complete detoxification can be achieved by administering an antidote in an amount more than twice the absorbed amount of the pesticide Dimecuron. However, it is generally impossible to determine the absorption amount of the pesticide Dimecuron during actual administration, and in such cases, the amount should be added every 30 minutes to 1 hour depending on the state of sedation of the attack. It is effective to administer the drug. Although the antidote according to the method of the present invention can be prepared in various dosage forms commonly considered in the pharmaceutical industry, oral and nasal administration are also effective, and therefore, the extract can be used directly as an antidote. It is also possible to use it as

Claims (1)

[Claims] 1 70% by weight of crushed dried oak leaves or bark,
A mixture (A,
Mix B) uniformly with water at a volume ratio of 1:3, steam this at 40 to 60°C for 5 to 6 hours, and extract the resulting steamed liquid under reduced pressure. , mixed with mixture (A, B) in a volume ratio of 3:1, and
After boiling under vacuum at 110°C for 0.5 to 1.0 hours and extracting it, boil the extract under vacuum at 110°C for 5 to 6 hours, and add glycerin to the extract obtained.
A method for producing an antidote for poisoning with the pesticide Dimecuron, which is characterized by adding 0.5% by weight and dispersing at high speed.