JPH0115385Y2 - - Google Patents
Info
- Publication number
- JPH0115385Y2 JPH0115385Y2 JP7774385U JP7774385U JPH0115385Y2 JP H0115385 Y2 JPH0115385 Y2 JP H0115385Y2 JP 7774385 U JP7774385 U JP 7774385U JP 7774385 U JP7774385 U JP 7774385U JP H0115385 Y2 JPH0115385 Y2 JP H0115385Y2
- Authority
- JP
- Japan
- Prior art keywords
- cap
- scalp
- polyvinyl alcohol
- gel
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001816 cooling Methods 0.000 claims description 34
- 210000004761 scalp Anatomy 0.000 claims description 34
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 23
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 150000002894 organic compounds Chemical class 0.000 claims description 17
- 239000007864 aqueous solution Substances 0.000 claims description 16
- 230000018044 dehydration Effects 0.000 claims description 10
- 238000006297 dehydration reaction Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- 238000007127 saponification reaction Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 2
- 230000008023 solidification Effects 0.000 claims description 2
- 239000013585 weight reducing agent Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 description 33
- 210000003128 head Anatomy 0.000 description 16
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 7
- 238000007710 freezing Methods 0.000 description 7
- 230000008014 freezing Effects 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229940009456 adriamycin Drugs 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 229960004679 doxorubicin Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 230000003658 preventing hair loss Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 229960002920 sorbitol Drugs 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000007798 antifreeze agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 210000004709 eyebrow Anatomy 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- DSLZVSRJTYRBFB-LLEIAEIESA-N D-glucaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O DSLZVSRJTYRBFB-LLEIAEIESA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 240000002836 Ipomoea tricolor Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000004886 head movement Effects 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Thermotherapy And Cooling Therapy Devices (AREA)
Description
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ãèªåšãªãèªåšå€åœ¢åé ç®ä¿å·åžœã«é¢ããã[Detailed Description of the Invention] <Industrial Application Field> The present invention relates to a scalp cooling cap, and particularly to a freely deformable scalp cooling cap that can be freely deformed while closely contacting the scalp.
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ãããšãã§ããªããšããæ¬ ç¹ããã€ãã<Prior art and problems> Various cooling gels have already been developed under the names of cooling gels, cold preservation gels, cold heat transfer media, colloidal refrigerants, cold preservation tools, cold preservation compositions, and ice pillows that do not require ice. have been proposed, and some have been put into practical use. Among these cooling devices, some are specifically designed to keep the scalp cool, but because they all have a predetermined shape and size, they are difficult to fit tightly to the entire scalp, and cannot be deformed freely. The drawback was that it could not be applied to people.
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ãä¿æãé£ãããšã¯æçœã§ããã Additionally, when attempting to keep the entire scalp cool by filling a hollow bag with simple cold water, ice water, viscous liquid, fluid soft gel, etc., it is inevitable that these fillers will flow downward and become unevenly distributed. Even if an attempt is made to adjust the shape with a band or the like, it is obvious that it is difficult to maintain the desired shape.
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ããã<Purpose of the invention> The object of the invention is to provide a scalp cooling cap that can be adapted to, adhered to, and covered the entire scalp of various shapes and sizes, and is deformable and easy to put on and take off. The present invention particularly provides a scalp cooling cap for preventing alopecia that occurs as a side effect of administering anticancer drugs.
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ç¹åŸŽãšããèªåšå€åœ¢åé ç®ä¿å·åžœãæäŸãããã<Means for Solving the Problems> According to the present invention, two of the flexible materials constituting a cap-shaped scalp cooling cap obtained by deaerating a hollow ball made of a flexible material. Inside the heavy cap wall, saponification degree is 98 mol% or more, average polymerization degree
Contains polyvinyl alcohol of 1000 or more, and
The concentration of the polyvinyl alcohol exceeds 8wt%,
After pouring an aqueous solution of 25wt% or less into a mold of any shape, it is cooled to a temperature of -10â or less, solidified, and molded, and then, without melting,
In addition, the dehydration rate (solidification/weight reduction rate of the molded product)
A freely deformable scalp cooling cap is provided, which is characterized in that a plurality of small pieces of a high water content gel obtained by vacuum/partial dehydration of 3 wt% or more are enclosed in a sealed manner.
以äžãæ¬èæ¡ã«ã€ããæŽã«è©³çŽ°ã«èª¬æããã The present invention will be explained in more detail below.
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ããã«ã¢ã«ã³ãŒã«ãçšããã®ã奜ãŸããã The polyvinyl alcohol used in the present invention requires a degree of saponification of 98 mol% or more, preferably 98.5 mol% or more. Saponification degree 80-88 mol%, especially 85
Even if less than mol% of polyvinyl alcohol is used,
A soft gel is obtained, but no rubber-like elastic body is produced. Further, the degree of polymerization of polyvinyl alcohol is required to be 1000 or more. Otherwise, a gel with poor mechanical strength tends to be produced. Therefore, it is preferable to use polyvinyl alcohol with a degree of polymerization of about 1000 to 3300, for example, a commercially available polyvinyl alcohol with a degree of polymerization of 1000 to 2600.
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åäœã®åœ¢ããã厩å£ã䌎ãåŸåã«ããã In the present invention, first, an aqueous solution or suspension aqueous solution containing the aforementioned polyvinyl alcohol is prepared. The concentration of polyvinyl alcohol can be more than 8 wt% and 25 wt% or less, preferably 9 to 15 wt%. When this concentration is increased above 25wt%,
It tends to produce a gel that is too hard for scalp cooling. Furthermore, if the concentration is lower than 8 wt%, the gel is too soft for cold storage, and the gel molded product tends to lose its shape and collapse.
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â15°ãâ20âãžéäžãããããšãã§ããã In order to use the scalp cooling cap obtained by the present invention without pre-cooling it to a low temperature below freezing point, for example, to about 0 to 10 degrees Celsius, it is sufficient to prepare an aqueous solution containing polyvinyl alcohol as described above. However, when pre-cooling the scalp cooling cap to below 0°C, a water-soluble organic compound is further dissolved in the polyvinyl alcohol aqueous solution to lower the freezing hardening point of the gel to below 0°C, e.g. It can be lowered to -15° to -20°C.
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ãŸããã In such a case, a water-soluble organic compound as an antifreeze agent (freezing point depressant) is dissolved in the polyvinyl alcohol aqueous solution prior to gel formation. Water-soluble organic compounds include water-soluble monohydric alcohols such as methyl alcohol, ethyl alcohol, and isopropyl alcohol and their derivatives, ethylene glycol, propylene glycol,
Water-soluble polyhydric alcohols such as 3-propylene glycol, glycerin, 2-methyl-2,4-pentanediol, other water-soluble polyhydric alcohols such as acetone, dimethylsulfoxide, methylsulfonic acid, ethylsulfonic acid, dimethylamine, methylamine, formic acid, etc. Examples include organic compounds. In addition, monosaccharides (erythritol, arabinose, xylose, xylitol, glucose, glucitol (sorbitol, sorbitol), gluconic acid, glucuronic acid, glucaric acid, galacturonic acid, fructose, glucosamine), disaccharides (sucrose,
cellobiose, lactose), trisaccharides (raffinose), water-soluble polysaccharides (agarose, amylose,
Sodium alginate, glycogen, chondroitin, chondroitin sulfate, dextran, pectic acid, propylene glycol alginate, gum tragacanth, pullulan, sodium chondroitin sulfate). Among these water-soluble organic compounds, the advantages are that they are odorless and have extremely low volatility, that they can achieve the objective of lowering the freezing point with a relatively small amount of substitution, and that they contribute to the mechanical strength of the resulting gel. In consideration of this, ethylene glycol, propylene glycol, glycerin, D-sorbitol, etc. are preferable.
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æ觊ãä¿æããããšãã§ããã The coexisting concentration of the water-soluble organic compounds mentioned above is:
The content is 5 to 40 wt%, preferably 10 to 35 wt%. When this coexisting concentration is lower than 10 wt%, it is difficult to lower the freezing/hardening point of the gel to -10°C or lower. Additionally, if the coexisting concentration is higher than 40wt%, the freezing point may be lowered unnecessarily, and freezing and
In some cases, this may actually increase the hardening point.
In either case, it unnecessarily increases the economic burden. By coexisting water-soluble organic compounds,
The curing temperature of the gel drops to below -20â, and it does not usually harden in the ice chamber (-10 to -20â) of a regular household refrigerator (freezer), maintaining flexibility and a feel similar to living tissue. I can do it.
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ã«èª¿æŽããã When preparing the above-mentioned aqueous solution containing both polyvinyl alcohol and a water-soluble organic compound as an antifreeze agent, in addition to adding, dissolving, or suspending polyvinyl alcohol and the water-soluble organic compound in water, A method in which polyvinyl alcohol is dissolved in water in advance and then mixed with the water-soluble organic compound (or its aqueous solution);
Alternatively, a method can be adopted in which a polyvinyl alcohol aqueous solution or polyvinyl alcohol powder is added, dissolved, or suspended in the water-soluble organic compound (or its aqueous solution). In either method, the final polyvinyl alcohol concentration is 8 wt.
% and below 25 wt%, and the concentration of the water-soluble organic compound is adjusted to 5 to 40 wt%.
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å·åŽã»æåããã In the present invention, the above-mentioned polyvinyl alcohol or an aqueous solution or suspension aqueous solution further containing a water-soluble organic compound is injected into a desired mold,
Cool and mold.
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ãããªãã In this case, the coolant may be, for example, salt-ice (23:77) (-21°C), calcium chloride-ice (30:
70) (-55°C), dry ice-methyl alcohol (-72°C), liquid nitrogen (-196°C), etc., to a temperature of -10°C or lower. In addition, liquid helium can be used to cool down to -269°C, but it is uneconomical and has no advantage in gel quality, so in practice a Freon refrigerator is used.
For example, it is best to cool it to -20 to -80°C. There is no harm in cooling it by storing it in a home refrigerator (freezer) or icemaker (-10 to -20â). This is followed by vacuum dehydration to obtain a solid gel. Note that insufficient cooling is not preferable for the present invention because the mechanical strength of the gel obtained is poor.
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å°éãããã Therefore, in the present invention, polyvinyl alcohol or an aqueous solution containing a water-soluble organic compound therein is heated to -10°C or lower, preferably -20°C or lower.
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ã«ã¯0.08mmïœä»¥äžã§è¡ãªãããšãã§ããã In the present invention, after the above-mentioned cooling treatment, the material is vacuum dehydrated without melting it. Dehydration rate (cooling/
As the weight loss rate of the solidified gel increases, the mechanical strength of the gel also improves, but if the use as a cold gel is considered, it is not necessary to significantly increase the dehydration rate to obtain a strong gel. Dehydration rate 3wt
% or more, preferably 3 wt % or more and 35 wt % or less from the viewpoint of flexibility and elasticity of the gel. The vacuum dehydration referred to herein means dehydration under reduced pressure, and the degree of reduced pressure is not particularly limited, but can be carried out at, for example, 1 mmHg or less, preferably 0.1 mmHg or less, and further 0.08 mmHg or less.
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ïŒcmã§ããã®ã奜ãŸããã In the present invention, the high water content gel obtained as described above is formed into small pieces. Polyvinyl alcohol or an aqueous solution containing a water-soluble organic compound is injected into a mold for forming small pieces, and multiple pieces of high water content gel are directly formed. You may also mold small pieces. Moreover, when not directly molding small pieces of high water content gel, the high water content gel obtained in an arbitrary shape can be cut into a plurality of small pieces. The shape of the small pieces of high water content gel is not particularly limited, and may be cubic, rectangular parallelepiped, cylindrical, etc.
It may have any shape such as a spherical shape, and its dimensions are not critical as long as it can be deformed by applying finger pressure from the outer surface when it is included in the cap wall as described later. As for size, dimensions such as one side or diameter are usually 2 mm ~
Preferably it is 3 cm.
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ã«åããã<Example> An embodiment of the head cooling cap of the present invention will be described with reference to the accompanying drawings. In FIG. 1, a plurality of small pieces of high water content gel (high water content rubber) obtained as described above are placed in a hollow ball 2 (spherical or ellipsoidal) made of a flexible material.
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ããšããã瀺ãã The amount of small pieces filled is preferably 0.3 kg or more from the viewpoint of the required cold storage capacity, but in consideration of the burden on the patient when wearing a cold cap, it is preferably 3 kg or less, 0.3 to 3 kg, particularly preferably 0.35 kg. By setting the weight to 2 kg, the purpose of preventing hair loss can be sufficiently achieved. As the flexible hollow ball 2 for storing this small piece, a hollow ball made of plastic film such as polyvinyl chloride, polyethylene, or polypropylene or a thin rubber ball is preferable from the viewpoint of feeling on the scalp and sealing property. Vinyl beach balls, balloons made of polypropylene/nylon laminated film, thin rubber balls made of candy rubber, etc. are most convenient, as well as rugby balls, American football balls, airships, and UFOs (flying saucers) made of the above-mentioned soft films. )
Model toys such as the above can also be used as long as they have the function of the spherical or oval spherical hollow ball of the present invention. In order to fit the small pieces 1 of the hydrous gel (hydrocarbon rubber) into these hollow balls, as necessary,
In addition to being able to provide a small piece inlet 3 on the wall of the hollow ball 2, a small piece inlet can also be provided in advance when manufacturing the hollow ball. In the present invention, after a predetermined amount of water-containing rubber pieces are input through the input port 3, unnecessary air inside the hollow ball is released. That is, in order to obtain a depression on the wall of the ball for covering the head, it is necessary to evacuate the inside of the hollow ball. If a large amount of air remains due to insufficient deaeration, the small pieces 1 will easily flow downward,
This interferes with uniform cooling throughout the scalp. Therefore, although the air release described above is extremely important, it is not necessary to completely eliminate all air.
Most of the air can be released by compressing the wall of the ball. After that, all the openings 3 on the wall of the ball are closed and sealed. In order to seal the opening, the opening can be heat-sealed, or the opening can be tied with a string, sealed with a seal, or adhered with an adhesive. FIG. 2 shows the scalp cooling cap 10 of the present invention obtained by degassing.
In the illustrated example, the opening 3 is sealed with a sealing plug 4.
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ãåããæ¬èæ¡ã®ä¿å·åžœïŒïŒãåŸãããã Due to the above-mentioned air release and ball wall sealing measures, the hollow ball inevitably has a crescent shape (boat shape, boat shape).
Thus, the ice pack 10 of the present invention is obtained.
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ãªã©ã§ããã As mentioned above, the high water content rubber filling amount is 0.3 to 3
However, setting the filling layer thickness to 3 cm or more means that the duration of cold storage is often extended unnecessarily and the patient is forced to bear extra weight, so the filling layer thickness is 0.6 kg. It is best to select the filling amount according to the size of the hollow ball so that the filling amount is ~2.5 cm, preferably 0.8 ~ 2 cm. An example of a preferred filling amount is for a hollow bowl with a diameter of 32 cm.
1.2-2Kg (filling layer thickness 0.8-2cm), 0.3-0.6Kg (filling layer thickness 0.8-2cm) in a hollow ball with a diameter of 16cm
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å¯çãããããä¿å·åžœã®åœ¢ç¶ãæçµçã«æŽããã When wearing the ice pack 10 of the present invention, place the recessed part (inside) 5 of the ice pack on the head 6 and apply finger pressure from the outer surface of the ice pack to move a part of the filling layer as appropriate. In addition to adjusting the entire area where hair exists to be almost uniformly covered with the filling layer, the cooling cap is adjusted to the shape of each patient's head by pinching the excess wall of the cooling cap with the fingertips. The shape of the ice pack is finally adjusted so that the size of the ice pack is appropriately shortened, or a fold 7 is attached to the excess portion exceeding the head circumference so that the ice cap fits tightly over the entire head area.
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§ïŒã In this invention, the cooling cap is designed to maintain close contact with the scalp after the patient puts it on, and to maintain this close contact even when the patient makes head movements such as shaking his head. Elastic band 8 around the hem
It is preferable to wrap and secure it with a band (band, flat fastener, elastic bandage) (see Figure 4).
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ãããšãã§ããã Regarding the dimensions of the hollow ball, consider the following points from the viewpoint of adhering and covering the entire scalp. That is, the head shapes of infants and children are close to spherical, and therefore, a hemispherical ice pack corresponding to the head circumference can cover almost the entire scalp. Furthermore, in order to keep eyebrows, nuchal region, side-whiskers, etc. cool, a cooler cap with a size that exceeds the head circumference is used, and an extra ball wall portion that exceeds the head circumference is used. After that, an elastic band 8 (plane fastener, magic belt) or an elastic bandage is wrapped around the hem of the ice-packed cap, and the ice-packed cap 10 is tightly fitted along the circumference of the head. In adults, the brain cranium (the part above the eyes) is not much different from that of children, but considering the long face and head height, it is especially desirable to wear a cold cap with a vertically long ball (ellipsoid). Using a spherical ball that exceeds the surrounding size, pinch or fold the excess wall of the ball (Figure 3), and as described above, wrap the elastic band 8 (belt) around the hem of the ice pack to shorten the ball diameter. However, it can also be shaped into a vertically long (vase-shaped) shape. Therefore, from the viewpoint of covering the entire hair, the hollow ball should be spherical with a diameter of 15 to 32 cm or with a shorter diameter.
A spherical shape with a diameter of 15 to 24 cm is preferable for infants (head circumference 33.5 to 51 cm), or an oval spherical shape with a minor axis of less than 12 to 24 cm and a major axis of 15 to 24 cm. circumference 50-52cm), diameter 17
~25cm spherical, or shorter axis 14-25cm, major axis 17
~25cm oval spherical shape, and in adults, 19-32cm in diameter
Spherical shape, or short axis less than 17-32cm, diameter 19-32cm
An elliptical spherical shape is preferred. In either case, these can cover not only the top of the head, but also the occiput, temporal region, eyebrows, etc.
The whiskers, nuchal region can also be covered.
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ä¿æãããã<Effects of the invention> In the present invention, the entire scalp can be covered with a filler made of small pieces of high water content gel 1, and by applying finger pressure and moving the filler appropriately, it can be formed into any shape according to the head shape of each patient. It is easy to deform, and moreover, the desired shape is maintained as it is after the finger pressure is released.
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çºæ®ããã The scalp cooling cap of the present invention is suitable for preventing hair loss caused by administering anticancer drugs to cancer patients, and is particularly suitable for Adriamycin, which is frequently used as an antibiotic, i.e. 14-hydroxydaunorubicin (doxorubicin).
It has great utility in preventing and inhibiting severe hair loss as a side effect of drugs such as daunorubicin and doxorubicin.
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ã·ã³ã泚å°ããã The usual method of using the ice pack of this invention is to store it in the refrigerator (3 to 10â) overnight, then wear it as described above before injecting adriamycin, and then apply the filling layer to the entire hair area, and then put it on as described above. , inject adriamycin.
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ãååéæãããã For example, if the thickness of the filling layer is 13 mm, the scalp temperature will be maintained at 25 degrees Celsius or less for 30 minutes after installation.
Similarly, the scalp temperature is maintained below 30°C for 60 min, but usually the scalp temperature is kept below 30°C for 15 min after injection.
By cooling to 25-30°C, the purpose of preventing hair loss is fully achieved.
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äºå·ããä¿å·åžœãšæŽæ°ããã®ãè¯ãã The injection time for Adriamycin is usually 5 minutes.
However, some hospitals require intravenous administration over 1 to 2 hours. For the latter example,
By increasing the thickness of the filling layer of the cooling cap of this invention to 2.5 to 3.5 cm, the duration of cold retention can be extended, but in consideration of the burden on the patient due to the filling material (weight), as mentioned above, Layer thickness 0.8~2cm
During the infusion period, it is recommended to replace the cap with a pre-chilled cooler every 30 to 60 minutes.
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ãããããã®ä¿å·åžœãå·å庫ïŒè£œæ°·å®€ãâ20âïŒ
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çããæ¹åŒãæ¡ããççšåŸ40ã
50minã«ããããé ç®æž©åºŠã20â以äžã«ä¿æãã
ããšãã§ããã Adriamycin dosage is 30-50mg
m -2 (dose per 1 m 2 of volumetric area) is customary, but higher doses, for example 60-80 mg m -2 (per kg of body weight, adults: 1.6-2.3 mg, 13-19 years old: 1.6-2.5 mg,
In some cases, 7-12 years old: 2-3.5 mg; 0-6 years old: 2.5-11 mg). When administering such a large amount, some people recommend that the scalp be deeply cooled (J.
G.Dean, SESalmon etal., N.Eng.J.Med.,
301, 253 (1977)). In order to meet this demand, high water content rubber obtained by the above-mentioned process using a water-soluble organic compound in combination is filled to a thickness of 2 to 3 cm.
What's more, you can store this ice pack in the freezer (ice maker, -20â).
The method is to pre-cool the product and then put it on.
Scalp temperature can be maintained below 20â for 50min.
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Figure 1 is a partially cutaway perspective view showing a small piece of high water content gel placed inside a hollow ball to make the scalp cooling cap of the present invention, and Figure 2 is a scalp cooling cap of the present invention obtained by degassing. A sectional view showing the cap, FIG. 3 is a schematic view showing the scalp cooling cap being worn, and FIG. 4 is a schematic view showing the flat fastener being wrapped. In the figure, 1 is a small piece of high water content gel, 2 is a hollow ball, 3 is a small piece inlet, and 10 is a scalp cooling cap.
Claims (1)
ããšã«ããåŸãããåžœå圢ç¶ã®é ç®ä¿å·åžœãæ§
æããåèšå¯ææ§ææã®äºéã®åžœåå£å ã«ãã
ãå床98ã¢ã«ïŒ 以äžãå¹³åéå床1000以äžã®ã
ãªããã«ã¢ã«ã³ãŒã«ãå«ã¿ãäžã€ã該ããªãã
ã«ã¢ã«ã³ãŒã«ã®æ¿åºŠã8wtïŒ ãè¶ ãã25wtïŒ ä»¥
äžã®æ°Žæº¶æ¶²ããä»»æ圢ç¶ã®æåçšé³åãžæ³šå ¥
åŸããããâ10â以äžã®æž©åºŠã«å·åŽã»åºåã»æ
åãã次ã«ããããè解ãããããšãªãããã
ã«ãè±æ°ŽçïŒåºåã»æåäœã®ééæžå°çïŒ3wt
ïŒ ä»¥äžã®ç空ã»éšåè±æ°ŽãæœããŠåŸãããé«å«
æ°Žã²ã«ã®å°çãè€æ°åãå¯å°å å«ãããããšã
ç¹åŸŽãšããèªåšå€åœ¢åé ç®ä¿å·åžœã (2) åèšæ°Žæº¶æ¶²ããæ¿åºŠïŒã40wtïŒ ã®æ°Žæº¶æ§æ
æ©ååç©ãå«ãããšãç¹åŸŽãšããå®çšæ°æ¡ç»é²
è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®èªåšå€åœ¢åé ç®ä¿å·
åžœã[Claims for Utility Model Registration] (1) Inside the double cap wall of the flexible material constituting a cap-shaped scalp cooling cap obtained by deaerating a hollow ball made of a flexible material After pouring an aqueous solution containing polyvinyl alcohol having a saponification degree of 98 mol% or more and an average polymerization degree of 1000 or more and having a concentration of the polyvinyl alcohol of more than 8 wt% and less than 25 wt% into a mold for forming any shape, This is cooled to a temperature below -10â, solidified, and molded, and then, without melting, the dehydration rate (solidification / weight reduction rate of the molded product) is 3wt.
1. A freely deformable scalp cooling cap, characterized in that a plurality of small pieces of high water content gel obtained by vacuum/partial dehydration of % or more are enclosed in a sealed manner. (2) The freely deformable scalp cooling cap according to claim 1, wherein the aqueous solution contains a water-soluble organic compound at a concentration of 5 to 40 wt%.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7774385U JPH0115385Y2 (en) | 1985-05-27 | 1985-05-27 | |
EP86107207A EP0208113B1 (en) | 1985-05-27 | 1986-05-27 | Deformable cap for scalp cooling |
DE8686107207T DE3678212D1 (en) | 1985-05-27 | 1986-05-27 | DEFORMABLE HOOD COOLING HOOD. |
US07/158,122 US5163425A (en) | 1985-05-27 | 1988-02-16 | Deformable cap for scalp cooling |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7774385U JPH0115385Y2 (en) | 1985-05-27 | 1985-05-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS61194519U JPS61194519U (en) | 1986-12-04 |
JPH0115385Y2 true JPH0115385Y2 (en) | 1989-05-09 |
Family
ID=30621091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7774385U Expired JPH0115385Y2 (en) | 1985-05-27 | 1985-05-27 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0115385Y2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010517717A (en) * | 2007-02-15 | 2010-05-27 | ãã£ã°ãã¿ãŒã ã¢ãŒã㌠| Head cooling device |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5420041B2 (en) * | 2012-01-26 | 2014-02-19 | ã¿ã«ãã·ååŠæ ªåŒäŒç€Ÿ | Cold insulator, bag for cold insulator and method of using cold insulator |
-
1985
- 1985-05-27 JP JP7774385U patent/JPH0115385Y2/ja not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010517717A (en) * | 2007-02-15 | 2010-05-27 | ãã£ã°ãã¿ãŒã ã¢ãŒã㌠| Head cooling device |
Also Published As
Publication number | Publication date |
---|---|
JPS61194519U (en) | 1986-12-04 |
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