JPH01111658A - Container for standard liquid etc. - Google Patents

Abstract

PURPOSE:To prevent the use of a concentrated liquid by providing a liquid container with a member for preventing the insertion of a liquid removal instrument therein at the height of the liquid surface below a predetermined height from the inner surface of the container bottom. CONSTITUTION:A member 5 for preventing the insertion of a liquid removal instrument is placed in a liquid container 1 provided with an opening portion sealable with a lid 2 at the upper part thereof at a predetermined height from the inner surface of the bottom thereof in such manner that the removal of the liquid becomes difficult, as the liquid surface is lowered below that height. This preventive member 5 may be either a platelike or netlike material and a clearance between this member and the inner surface of wall in the liquid storing portion of the container is sufficiently large to allow the full flowing of the liquid. It is important that the material thereof be the type which does not affect the liquid composition. The preventive member is fixed at a height corresponding to that of the liquid in the minimum limit of the amount, with changes in the liquid concentration resulting from evaporation confined within a practically negligible limit. This method makes removal of the liquid impossible, when it is reduced to such an amount that changes in the liquid concentration due to the opening of the container poses a problem, thereby practically preventing the errors of analysis due to variations in the liquid concentration.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a container for storing a solution having a fixed composition and dispensing the same a plurality of times for use.

Specifically, it is a container for storing solutions such as standard solutions, control solutions, and reference solutions that are routinely used in the field of analytical chemistry, particularly in the field of clinical chemistry testing.

[Prior Art] In the field of analytical chemistry, especially in the field of clinical chemistry testing, analysis is often performed using a solution of a certain concentration as a standard.This standard solution includes a standard solution, Calibrator-1 test solution,
There are various liquids called control liquids, reference liquids, etc. Particularly, in the case of commercially available products, which are widely used routinely in the field of clinical chemistry testing and are often commercially available, such solutions are stored in vials with a capacity of 5 to 10 ml. Since the opening area of a vial is large compared to its volume, the repeated opening and closing of the lid to take out the liquid causes evaporation of the solvent, which has a non-negligible effect on the accuracy of analysis. As a general rule, containers containing heavy liquids, etc. should be tightly capped before performing analytical operations, and the caps should be removed only when they are taken out in a vial, and then capped again after fractionation, but in general, standard solutions, etc. It is taken out and used several thousand to hundreds of times, and during that time evaporation progresses little by little.As the amount of remaining liquid decreases, its concentration increases.In an emergency, it is unavoidable to close the stopper. In this case, evaporation proceeds rapidly, resulting in a higher concentration of the solution used as a reference for the analysis and incorrect measurement results.

Biological body fluids (whole blood, plasma,
High precision is required for constant flea analysis of target components (analytes) in cerebrospinal fluid, urine, saliva, etc., but concentrating the standard solution will cause measurement errors, making analytical measurements difficult. It may become a serious problem. In particular, N a ” in the blood
The electrolyte ion concentration such as , K', CI- is
In a normal living body, homeostasis is maintained within a very narrow range, and measurement errors pose an extremely serious problem in clinical diagnosis. Therefore, the use of liquids should be avoided if they have become undesirably concentrated due to evaporation of the solvent.

Measuring the concentration of a stored solution each time it is used is time consuming and impractical.

[Technical Issue II to be Solved] In the present invention, in a liquid container having an opening at the top that can be sealed tightly, a conventionally shaped bottle is used as is, making it inconvenient to take out the liquid. The technical challenge is to make it impossible to use undesirably concentrated liquids without any problems.

[Means for solving technical problems] In the present invention, in a liquid container having a sealable opening at the top, a member for preventing the insertion of a liquid sampling device is provided at a certain height from the inner bottom surface, The above problem was solved by making it difficult to collect the liquid when the liquid level drops.

[Details of specific configuration] The member for preventing the insertion of the liquid sampling device (hereinafter referred to as the blocking member) may be in the form of a plate or may be a net, and this member and the container for liquid storage. The gap between the container and the inner surface of the container is preferably large enough to allow sufficient liquid flow. Part of the outer edge may be in contact with the inner wall of the container. When the container is most commonly cylindrical, , the above-mentioned member can have various shapes such as disc, hexagon, square, rectangle, and triangle.

It may be solid (having no cavity) or hollow.

The blocking member may also be a plate-like member whose outer edge is in contact with the inner wall of the container and has a small hole provided except near the center.

The material constituting the blocking member may have a specific gravity greater than or less than that of the liquid. It is important that the material of the blocking member is one that does not affect the liquid composition. Examples of suitable materials include glass, silicone rubber, Teflon, polyvinyl chloride, polystyrene, acrylic resin, nickel, stainless steel, etc. with a specific gravity of more than 1, and polyethylene and polypropylene with a specific gravity of less than 1.

The height at which the blocking member is fixed is such that the liquid can be freely collected only for liquid I in which concentration due to evaporation is practically negligible. That is, the blocking member is fixed at a height corresponding to the minimum amount of liquid in a range where concentration due to evaporation can be practically ignored. To fix the blocking member at a constant height from the bottom of the liquid,
The blocking member may be provided with a suitable support member, or the inner wall of the container may be provided with a suitable support member and locked thereto.If the blocking member is provided with a support member, the support member may be provided with a suitable support member to prevent it from floating in the liquid. It is necessary to The upper surface of the blocking member does not necessarily have to be horizontal. It is desirable that the structure and material of the blocking member are such that they do not damage the tip of a liquid sampling device, such as a pipette.

FIG. 1 shows a sectional view of a specific example of the container of the present invention. A shows a case where a disc-shaped blocking member is used, and B and C show a case where a net is used as the blocking member 5.

In A and B, the blocking member is supported by a support. In C, the blocking member is supported by a protrusion provided on the inner wall of the container.

It goes without saying that the container must be able to be sealed tightly.
It is convenient if the blocking member can be inserted into the container through the mouth of the container, but there is also a method in which the blocking member is inserted in advance when the container is manufactured. It is also desirable that the structure, including the support pillars, be easy to clean.

[Effects of the Invention] When the container of the present invention is used, the liquid can be easily taken out with a pipette or the like as usual, and when the amount of the liquid falls below a certain limit, taking out the liquid is prevented.

In a normal cylindrical container, the area of the liquid surface is almost constant regardless of the amount of liquid, so the amount of evaporation per opening of the cap is almost constant, and when the amount of liquid is large, the effect on concentration is negligible. Even if it is small, the influence on the concentration cannot be ignored as the liquid volume becomes small.

In the container of the present invention, if the liquid volume decreases to such a level that concentration by opening the cap becomes a problem, the liquid cannot be taken out.
Analytical errors due to fluctuations in concentration of the liquid can be substantially prevented.
mm), a polyvinyl chloride plate with a thickness of 1 ms and a diameter of 0.
Figure 1 B
As shown in Figure 2, it was fixed on an L-shaped support stand made of stainless steel and having a height of 20 mm. Due to the mesh in this container, liquid cannot be collected if the leakage amount is less than 8 ml.

A reference solution for measuring potassium ions from 10 companies having a concentration of 4.2 mg/1 was injected into the container. 50 μl each time the bottle is opened
When taking out one by one, it was possible to take out about 40 times.

The cap was opened once a day, and the concentration of the last sampled reference solution was 4.4.
Milligram per J#/1. In other words, the increase in concentration upon opening the bottle was within 0.2 milligrams/1 from the initial concentration.

For comparison, if a similar container without the blocking member (vinyl chloride #i7) was used, it could be sampled approximately 200 times, but 1
When the liquid volume was reduced to 5 ml after sampling 00 times, the concentration of the reference liquid was 4.7 mg per 1/1, resulting in a concentration increase of 11/1 per 0.5 mg. As a reference solution for measuring potassium ion concentration, such concentration fluctuations cannot be observed in practice.

The examples described above are about reference solutions used for ion selection and electrolysis, but they are not limited to this, and include standard solutions and calibration solutions for other general chemical analyzes and clinical chemistry tests.
This is useful when it is desired to avoid changes in the concentration of the contents of the container due to evaporation.

[Brief explanation of the drawing]

FIG. 1 is a sectional view showing a specific example of the container of the present invention. A
1 is the case where a disc-shaped blocking member is used, and B and C are the cases where a net is used as the blocking member 5. FIG. 2 is a sectional view showing a conventional liquid container. The meanings of the symbols in Figures 1 and 2 are as follows. 1: Container body 1a Male thread part 2: Lid 2a: Female thread part 3; Gasket 4: Liquid 5: Collection prevention member 6: Support member Applicant: Fuji Photo Film Co., Ltd. 1. Indication of the case Patent Application No. 260358 filed in 1988 2. Name of the invention Liquid container for standard solution, etc. 3. Relationship with the person making the amendment 11. Patent applicant Location 21Ofi Nakanuma, Minamiashigara City, Kanagawa Prefecture Place name (520) Fuji Photo Film Co., Ltd. Contact information: 2-26-30 Nishiazabu, Minato-ku, Tokyo Fuji Photo Film Co., Ltd. Tokyo Head Office Telephone: (406) 2537 4. Date of amendment order: January 26, 1988 (starting gate)
6. Contents of the amendment Figure 3 will be deleted.

Claims (5)

[Claims] (1) A liquid container with an opening at the top that can be sealed tightly, and if the liquid level is below a certain height from the inner bottom, it is difficult to collect the liquid, so the liquid is collected at the above height. A liquid container characterized by being provided with a member for preventing insertion of an instrument. (2) The container according to claim (1), wherein the liquid is a solution used as a standard in chemical analysis. (3) Claim (1), wherein the liquid is a solution used as a standard for chemical analysis in clinical chemistry tests.
Container as described. (4) The container according to claim (1), wherein the member for preventing insertion of the liquid sampling device is a net. (5) The container according to claim (1), wherein the member is plate-shaped.