JP7794735B2 - 切替え療法によるｒｍｓの治療 - Google Patents

切替え療法によるｒｍｓの治療

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Publication number
JP7794735B2
JP7794735B2 JP2022515966A JP2022515966A JP7794735B2 JP 7794735 B2 JP7794735 B2 JP 7794735B2 JP 2022515966 A JP2022515966 A JP 2022515966A JP 2022515966 A JP2022515966 A JP 2022515966A JP 7794735 B2 JP7794735 B2 JP 7794735B2
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Japan
Prior art keywords
ofatumumab
pharmaceutical composition
disease
administered
administration
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022515966A
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English (en)
Japanese (ja)
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JP2022548575A5 (enExample
JP2022548575A (ja
Inventor
ラマナサン，クリシュナン
エイドリアン ヘリング，ディーター
バガー，モルテン
メルシュヘムケ，マルティン
ツィーン，マリナ
ピンギリ，ラトネーカー
Original Assignee
ノバルティス アーゲー
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Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2022548575A publication Critical patent/JP2022548575A/ja
Publication of JP2022548575A5 publication Critical patent/JP2022548575A5/ja
Priority to JP2025159217A priority Critical patent/JP2026016387A/ja
Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022515966A 2019-09-11 2020-09-10 切替え療法によるｒｍｓの治療 Active JP7794735B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025159217A JP2026016387A (ja) 2019-09-11 2025-09-25 切替え療法によるｒｍｓの治療

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19196789 2019-09-11
EP19196789.2 2019-09-11
EP20154736.1 2020-01-30
EP20154736 2020-01-30
PCT/EP2020/075332 WO2021048280A1 (en) 2019-09-11 2020-09-10 Treatment of rms by switching therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025159217A Division JP2026016387A (ja) 2019-09-11 2025-09-25 切替え療法によるｒｍｓの治療

Publications (3)

Publication Number Publication Date
JP2022548575A JP2022548575A (ja) 2022-11-21
JP2022548575A5 JP2022548575A5 (enExample) 2023-09-13
JP7794735B2 true JP7794735B2 (ja) 2026-01-06

Family

ID=72709332

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022515966A Active JP7794735B2 (ja) 2019-09-11 2020-09-10 切替え療法によるｒｍｓの治療
JP2025159217A Pending JP2026016387A (ja) 2019-09-11 2025-09-25 切替え療法によるｒｍｓの治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025159217A Pending JP2026016387A (ja) 2019-09-11 2025-09-25 切替え療法によるｒｍｓの治療

Country Status (15)

Country Link
US (1) US20220298253A1 (enExample)
EP (2) EP4230655A3 (enExample)
JP (2) JP7794735B2 (enExample)
KR (1) KR20220062025A (enExample)
CN (3) CN114401742B (enExample)
AU (1) AU2020344154A1 (enExample)
CA (1) CA3150947A1 (enExample)
DK (1) DK3864053T3 (enExample)
ES (1) ES2957112T3 (enExample)
FI (1) FI3864053T3 (enExample)
IL (1) IL290619A (enExample)
LT (1) LT3864053T (enExample)
MX (1) MX2022003010A (enExample)
SI (1) SI3864053T1 (enExample)
WO (1) WO2021048280A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3733712T (lt) 2016-08-15 2023-09-11 Novartis Ag Išsėtinės sklerozės gydymo schemos ir būdai, panaudojant ofatumumabą
US20220389109A1 (en) * 2019-09-11 2022-12-08 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients
EP4707302A2 (en) * 2020-04-09 2026-03-11 Novartis AG Ofatumumab for treating ms while maintaining serum igg
WO2022219057A1 (en) * 2021-04-14 2022-10-20 Novartis Ag Ofatumumab for treating multiple sclerosis in asian patients

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0315295C1 (pt) 2002-10-17 2021-05-25 Genmab As anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão
UA107557C2 (xx) 2007-07-06 2015-01-26 Композиція антитіла офатумумабу
AR073295A1 (es) * 2008-09-16 2010-10-28 Genentech Inc Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.
EP2692343A1 (en) * 2012-08-03 2014-02-05 Forward Pharma A/S Combination therapy for treatment of multiple sclerosis
WO2015168103A1 (en) * 2014-04-29 2015-11-05 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
LT3733712T (lt) 2016-08-15 2023-09-11 Novartis Ag Išsėtinės sklerozės gydymo schemos ir būdai, panaudojant ofatumumabą

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Multiple Sclerosis Journal, 2018, Vol. 24, No. S2, pp. 526-527
Neurology, 2014, Vol. 82, pp. 573-581
Neurology, 2018, Vol. 90, pp. e1805-e1814, Short-form article, Supplementary Methods and Results
NOVARTIS, A randomized, double-blind, double-dummy, parallel-group study comparing the efficacy and safety of ofatumumab versus teriflunomide in patients with relapsing multiple sclerosis，2018年08月06日, [retrieved on 2024.06.05], Retrieved from the Internet: <URL: https://cdn.clinicaltrials.gov/large-docs/31/NCT02792231/Prot_001.pdf>

Also Published As

Publication number Publication date
MX2022003010A (es) 2022-06-02
CN118403156A (zh) 2024-07-30
LT3864053T (lt) 2023-09-11
ES2957112T3 (es) 2024-01-11
WO2021048280A1 (en) 2021-03-18
JP2026016387A (ja) 2026-02-03
EP3864053B1 (en) 2023-07-05
IL290619A (en) 2022-04-01
CN114401742A (zh) 2022-04-26
CN114401742B (zh) 2024-05-24
FI3864053T3 (fi) 2023-09-13
EP4230655A2 (en) 2023-08-23
KR20220062025A (ko) 2022-05-13
US20220298253A1 (en) 2022-09-22
CN118436777A (zh) 2024-08-06
EP4230655A3 (en) 2023-11-01
CA3150947A1 (en) 2021-03-18
EP3864053A1 (en) 2021-08-18
AU2020344154A1 (en) 2022-04-07
JP2022548575A (ja) 2022-11-21
SI3864053T1 (sl) 2023-12-29
DK3864053T3 (da) 2023-09-11

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