JP7750853B2 - 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法 - Google Patents

皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

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JP7750853B2
JP7750853B2 JP2022557605A JP2022557605A JP7750853B2 JP 7750853 B2 JP7750853 B2 JP 7750853B2 JP 2022557605 A JP2022557605 A JP 2022557605A JP 2022557605 A JP2022557605 A JP 2022557605A JP 7750853 B2 JP7750853 B2 JP 7750853B2
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group
carbon atoms
alkyl group
hydrogen atom
skin sensitization
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JPWO2022085762A1 (https=
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崇 田村
正晴 藤田
裕介 山本
浩二 高久
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Fujifilm Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/067—Preparation by reaction, e.g. derivatising the sample

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2022557605A 2020-10-22 2021-10-21 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法 Active JP7750853B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020177157 2020-10-22
JP2020177157 2020-10-22
PCT/JP2021/038929 WO2022085762A1 (ja) 2020-10-22 2021-10-21 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

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JPWO2022085762A1 JPWO2022085762A1 (https=) 2022-04-28
JP7750853B2 true JP7750853B2 (ja) 2025-10-07

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EP (1) EP4234537A4 (https=)
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JP1711931S (ja) * 2021-10-19 2022-04-06 印刷機
USD1013032S1 (en) * 2022-05-20 2024-01-30 Kyocera Corporation Inkjet printer
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009222466A (ja) 2008-03-14 2009-10-01 Sumitomo Chemical Co Ltd 蛍光システイン誘導体を用いる感作性検定方法及び蛍光システイン誘導体
US20140227793A1 (en) 2013-02-14 2014-08-14 California Institute Of Technology Compositions and methods for glycan sequencing
WO2020045621A1 (ja) 2018-08-31 2020-03-05 富士フイルム株式会社 皮膚感作性の測定方法および皮膚感作性測定試薬
WO2021060477A1 (ja) 2019-09-26 2021-04-01 富士フイルム株式会社 皮膚感作性測定試薬、皮膚感作性の測定方法、及び化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5745458A (en) * 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Immunologic method for trace analysis
ES2061586T3 (es) * 1987-10-30 1994-12-16 American Cyanamid Co Analogos disulfuricos de agentes antitumorales ll-e33288.
JP4595257B2 (ja) 2001-06-29 2010-12-08 住友化学株式会社 皮膚感作性検定方法
JP2008139275A (ja) 2006-11-02 2008-06-19 Sumitomo Chemical Co Ltd 皮膚感作性検定方法
EP2207030A4 (en) * 2007-10-05 2010-12-08 Univ Hokkaido DEVICE FOR AUTOMATIC PRE-TREATMENT OF A SUGAR CHAIN
JP5466105B2 (ja) 2009-08-13 2014-04-09 富士フイルム株式会社 皮膚感作性測定試薬
JP5997543B2 (ja) 2012-08-13 2016-09-28 富士フイルム株式会社 皮膚感作性測定試薬

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009222466A (ja) 2008-03-14 2009-10-01 Sumitomo Chemical Co Ltd 蛍光システイン誘導体を用いる感作性検定方法及び蛍光システイン誘導体
US20140227793A1 (en) 2013-02-14 2014-08-14 California Institute Of Technology Compositions and methods for glycan sequencing
WO2020045621A1 (ja) 2018-08-31 2020-03-05 富士フイルム株式会社 皮膚感作性の測定方法および皮膚感作性測定試薬
WO2021060477A1 (ja) 2019-09-26 2021-04-01 富士フイルム株式会社 皮膚感作性測定試薬、皮膚感作性の測定方法、及び化合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AKIMOTO, Miyuki et al.，Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay，Journal of Applied Toxicology，2020年02月12日，Vol.40，pp.843-854
CHO, Sun-A et al.，High-throughput screening (HTS)-based spectrophotometric direct peptide reactivity assay (Spectro-DPRA) to predict human skin sensitization，Toxicology Letters，2019年，Vol.314，pp.27-36
須藤 英典 他，皮膚感作性評価の現状と今後の展望，住友化学，2019年，pp.24-36

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US20230258569A1 (en) 2023-08-17
EP4234537A4 (en) 2024-05-29
WO2022085762A1 (ja) 2022-04-28
JPWO2022085762A1 (https=) 2022-04-28
EP4234537A1 (en) 2023-08-30

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