JP7561133B2 - Ｔ細胞受容体及びその使用方法 - Google Patents

Ｔ細胞受容体及びその使用方法 Download PDF

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JP7561133B2
JP7561133B2 JP2021552600A JP2021552600A JP7561133B2 JP 7561133 B2 JP7561133 B2 JP 7561133B2 JP 2021552600 A JP2021552600 A JP 2021552600A JP 2021552600 A JP2021552600 A JP 2021552600A JP 7561133 B2 JP7561133 B2 JP 7561133B2
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tcr
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amino acid
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JP2022523554A5 (https=
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直人 平野
憲治 村田
薫葉子 佐相
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ユニバーシティー ヘルス ネットワーク
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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JP2021552600A 2019-03-04 2020-03-03 Ｔ細胞受容体及びその使用方法 Active JP7561133B2 (ja)

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US201962813642P 2019-03-04 2019-03-04
US62/813,642 2019-03-04
PCT/IB2020/051808 WO2020178739A1 (en) 2019-03-04 2020-03-03 T cell receptors and methods of use thereof

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CN (1) CN113906141B (https=)
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Cited By (1)

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JP2025000725A (ja) * 2019-03-04 2025-01-07 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体及びその使用方法

Families Citing this family (5)

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JP7748284B2 (ja) 2019-03-04 2025-10-02 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体及びその使用方法
MX2021010541A (es) 2019-03-04 2021-12-15 Univ Health Network Receptores de linfocitos t y metodos de uso de estos.
CN113795586B (zh) 2019-03-25 2026-03-27 大学健康网络 T细胞受体及其使用方法
CA3233809A1 (en) * 2021-10-06 2023-04-13 University Health Network Modified immune cells and methods of use thereof
AU2024269870A1 (en) * 2023-05-05 2025-11-20 Board Of Regents, The University Of Texas System Multi-receptor natural killer cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013162797A (ja) 2007-06-11 2013-08-22 Takara Bio Inc 特異的遺伝子発現方法
JP2013541332A (ja) 2010-09-20 2013-11-14 ビオエンテッヒ・アクチェンゲゼルシャフト 抗原特異的ｔ細胞受容体およびｔ細胞エピトープ
JP2016523891A (ja) 2013-06-28 2016-08-12 オークランド ユニサービシーズ リミティド アミノ酸及びペプチド接合体及び接合方法
JP2017508480A (ja) 2014-03-12 2017-03-30 ナショナル キャンサー センター 自己癌抗原特異的ｃｄ８＋ｔ細胞の分離及び増殖方法

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Publication number Priority date Publication date Assignee Title
WO2017076308A1 (zh) * 2015-11-04 2017-05-11 广州市香雪制药股份有限公司 识别ny-eso-1抗原短肽的tcr
WO2017120428A2 (en) * 2016-01-06 2017-07-13 Health Research, Inc. Compositions and libraries comprising recombinant t-cell receptors and methods of using recombinant t-cell receptors
AU2020231927A1 (en) * 2019-03-04 2021-09-30 University Health Network T cell receptors and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013162797A (ja) 2007-06-11 2013-08-22 Takara Bio Inc 特異的遺伝子発現方法
JP2013541332A (ja) 2010-09-20 2013-11-14 ビオエンテッヒ・アクチェンゲゼルシャフト 抗原特異的ｔ細胞受容体およびｔ細胞エピトープ
JP2016523891A (ja) 2013-06-28 2016-08-12 オークランド ユニサービシーズ リミティド アミノ酸及びペプチド接合体及び接合方法
JP2017508480A (ja) 2014-03-12 2017-03-30 ナショナル キャンサー センター 自己癌抗原特異的ｃｄ８＋ｔ細胞の分離及び増殖方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025000725A (ja) * 2019-03-04 2025-01-07 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体及びその使用方法

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