JP7480398B2 - Ophthalmic analysis device, method for analyzing test eye data, and ophthalmic analysis program - Google Patents

Description

The disclosure of this specification relates to an ophthalmic analysis apparatus, a method for analyzing test eye data, and an ophthalmic analysis program.

Patent Document 1 discloses that an analysis region for OCT motion contrast data is set based on a region set in OCT data acquired by an optical coherence tomography, and analysis processing is performed.

Patent Publication No. 2020-44362

However, the method described in Patent Document 1 merely identifies areas with tissue structure defects based on OCT images and analyzes the blood flow conditions in the identified areas. It is difficult to identify areas where there is no abnormality in the tissue structure but where blood flow disorders are occurring inside blood vessels and to analyze the tissue structure of the identified areas.

In addition, follow-up observations require multiple and complicated procedures to check for changes over time in multiple areas using different types of images, making it difficult to make a rapid diagnosis.

In order to solve the above problems,
An ophthalmic analysis apparatus according to a first aspect of the disclosure of this specification,
An ophthalmologic analysis device for analyzing data of a subject's eye acquired by an optical coherence tomography, comprising:
a subject's eye data acquiring means for acquiring first image data of the subject's eye acquired in an examination on a first examination date, and second image data different in type from the first image data and corresponding to the first image data;
a two-dimensional image acquiring means for acquiring a two-dimensional image based on the image data acquired by the subject's eye data acquiring means;
and an analysis region setting means for setting an analysis region of the second image data based on a position on a first two-dimensional image based on third image data acquired in an examination on a second examination date different from the first examination date, the third image data being image data of the same type as the first image data;
This is an ophthalmological analysis device , characterized in that one of the first image data, the third image data, and the second image data is OCT data, and the other is OCT motion contrast data .

In addition, an ophthalmic analysis apparatus according to another aspect of the present specification includes:
An ophthalmologic analysis device for analyzing data of a subject's eye acquired by an optical coherence tomography, comprising:
An ophthalmologic analysis device for analyzing data of a subject's eye acquired by an optical coherence tomography, comprising:
A subject's eye data acquisition means for acquiring OCT data of the subject's eye and OCT motion contrast data corresponding to the OCT data;
an OCT front image acquisition means for acquiring an OCT front image based on the OCT data;
and an analysis region setting means for setting an analysis region of the OCT motion contrast data,
The analysis region setting means is an ophthalmologic analysis device that sets an analysis region of the OCT motion contrast data based on a position on an OCT front image based on OCT data acquired in a past examination.

In addition, a method for analyzing test eye data according to another aspect of the present specification includes:
A method for analyzing data of a subject's eye acquired by an optical coherence tomography, comprising the steps of:
a test eye data acquiring step of acquiring first image data of the test eye acquired in an examination on a first examination date, and second image data different in type from the first image data and corresponding to the first image data;
a two-dimensional image acquiring step of acquiring a two-dimensional image based on the image data acquired in the subject's eye data acquiring step;
An analysis area setting step of setting an analysis area of the second image data,
The analysis area setting step is a step of setting an analysis area of the second image data based on a position on a first two-dimensional image based on third image data which is obtained during an examination on a second examination date different from the first examination date and is the same type of image data as the first image data, and the method for analyzing test eye data is characterized in that one of the first image data and the third image data, and the second image data, is OCT data, and the other is OCT motion contrast data .

In addition, a method for analyzing test eye data according to another aspect of the present specification includes:
A method for analyzing data of a subject's eye acquired by an optical coherence tomography, comprising the steps of:
A test eye data acquisition step of acquiring OCT data of the test eye and OCT motion contrast data corresponding to the OCT data;
an OCT front image acquisition step of acquiring an OCT front image based on the OCT data;
An analysis region setting step of setting an analysis region of the OCT motion contrast data,
The method for analyzing test eye data is a step of setting an analysis area of the OCT motion contrast data based on a position on an OCT frontal image based on OCT data acquired in a previous examination, in which the analysis area setting step is a step of setting an analysis area of the OCT motion contrast data based on a position on an OCT frontal image based on OCT data acquired in a previous examination.

In addition, an ophthalmic analysis program according to another aspect of the present specification includes:
An ophthalmic analysis program capable of executing the subject eye data analysis method according to the disclosure of this specification on an ophthalmic analysis device.

The present invention not only enables more effective analysis of areas with impaired blood flow, but also enables rapid comparison during follow-up observation.

2 is an example of an ophthalmologic analysis apparatus according to the present embodiment. FIG. 2 is a diagram illustrating an example of an optical system of an OCT device. 1 is a diagram for explaining an example of a method for acquiring OCT motion contrast data. FIG. 13 is a diagram showing an example of an analysis screen. 11 is a diagram showing an example of time-series data of first image data and second image data relating to a section specified by an examiner; FIG. FIG. 1 is a diagram showing a flow of a first embodiment. FIG. 13 is a diagram showing an example of an analysis screen according to the first embodiment. FIG. 13 is a diagram showing an example of an analysis screen according to the second embodiment. FIG. 13 is a diagram showing an example of an analysis screen according to the third embodiment. 13A and 13B are diagrams illustrating an example of an instruction receiving GUI and time-series data according to a third embodiment. 13A and 13B are diagrams illustrating an example of an instruction receiving GUI and time-series data according to a third embodiment. FIG. 13 is a diagram showing an example of an analysis screen according to the fourth embodiment.

<Ophthalmological analysis device>
The ophthalmic analysis apparatus of this embodiment executes an ophthalmic analysis program by a processor and performs an analysis process of data of a subject's eye.

Figure 1 is a diagram showing an ophthalmological analysis device that is an example of an ophthalmological analysis device of this embodiment.

The ophthalmic analysis apparatus 100 of this embodiment has a control unit 200,
The control unit 200 has a CPU, an analysis processing program for processing OCT data and OCT motion contrast data, a flash ROM in which a program for controlling the operation of the test eye data acquisition device 600 to acquire first image data and second image data is stored, a RAM that functions as a temporary storage medium, and the like.

As shown in FIG. 1, the control unit 200 is connected to a memory unit 300, an operation unit 40, and a display unit 50.

The operation unit 40 is, for example, a mouse, a keyboard, or a touch panel, and the user can input instructions to the test eye data acquisition unit 600 and the ophthalmic analysis device 100 via the operation unit 40. When the operation unit 40 is a touch panel, the operation unit 40 can be configured as one unit with the display unit 50.

The display unit 50 is configured with any display and can display data and various images acquired by the subject's eye data acquisition device 600. The display unit 50 may be mounted on or connected to the main body of the ophthalmic analysis device 100.

The subject eye data acquisition device 600 may be, for example, an OCT device and may be connected to the ophthalmic analysis device 100.

The ophthalmic analysis device 100 may be in a separate housing from the subject eye data acquisition device 600, or may be in the same housing. The control unit 200 may control the connected subject eye data acquisition device 600 to acquire the first image data and the second image data, or may acquire the first image data and the second image data from a source other than the ophthalmic analysis device 100 and the subject eye data acquisition device 600 via a server, a storage medium, etc.

<Examined Eye Data Acquisition Device>
The subject's eye data acquisition device 600 will now be briefly described.

The subject's eye data acquisition device 600 acquires first image data including a predetermined portion of the subject's eye and second image data that is of a different type from the first image data and has position information associated with the first image data.

When the subject eye data acquisition device 600 is an OCT device, it may have a configuration as shown in FIG. 2, for example.

Objective lens 1 is placed facing the subject's eye Er, and a first dichroic mirror 2 and a second dichroic mirror 3 are arranged on its optical axis. These dichroic mirrors split the light into three wavelength bands: optical path L1 for the OCT optical system, optical path L2 for the observation optical system and fixation lamp for observing the subject's eye Er, and optical path L3 for observing the anterior segment.

The optical path L2 for the observation optical system and fixation lamp has an SLO scanning means 4, lenses 5 and 6, a mirror 7, a third dichroic mirror 8, a photodiode 9, an SLO light source 10, and a fixation lamp 11.

Mirror 7 is a prism with a holed mirror or a hollow mirror deposited on it, and separates the illumination light from the SLO light source 10 from the return light from the subject's eye. The third dichroic mirror 8 separates the light into wavelength bands for the optical paths to the SLO light source 10 and the fixation lamp 11.

The SLO scanning means 4 scans the light emitted from the SLO light source 10 and fixation lamp 11 on the subject's eye Er, and is composed of an X scanner that scans in the X direction and a Y scanner that scans in the Y direction. In this embodiment, the X scanner is composed of a polygon mirror because high-speed scanning is required, and the Y scanner is composed of a galvanometer mirror.

Lens 5 is driven by a motor (not shown) to focus the SLO optical system and the fixation lamp. SLO light source 10 generates light with a wavelength of about 780 nm. Photodiode 9 detects the return light from the subject's eye. Fixation lamp 11 generates visible light to encourage the subject to fixate.

The light emitted from the SLO light source 10 is reflected by the third dichroic mirror 8, passes through the mirror 7, passes through the lenses 6 and 5, and is scanned on the subject's eye Er by the SLO scanning means 4. The returning light from the subject's eye Er travels the same path as the projected light, is reflected by the mirror 7, and is directed to the photodiode 9.

The fixation light 11 passes through the third dichroic mirror 8 and mirror 7, passes through lenses 6 and 5, and is scanned on the subject's eye Er by the SLO scanning means 4. At this time, the fixation light 11 is blinked in accordance with the movement of the SLO scanning means 4, creating an arbitrary shape at an arbitrary position on the subject's eye Er, encouraging the subject to fixate.

In the optical path L3 for observing the anterior segment, a lens 12, a split prism 13, a lens 14, and a CCD 15 for observing the anterior segment are arranged. This CCD 15 has sensitivity to the wavelength of the light source for observing the anterior segment (not shown), specifically, around 970 nm.

The split prism 13 is positioned conjugate with the pupil of the test eye Er, and can detect the distance in the Z direction (front-back direction) between the test eye Er and the test eye data acquisition device 600 as a split image of the anterior segment.

An XY scanner 16 and lenses 17 and 18 are arranged in the optical path L1 of the OCT optical system for capturing image data of the test eye Er. The XY scanner 16 is used to scan the test eye Er with light from the OCT light source 20. Although the XY scanner 16 is illustrated as a single mirror, it is a galvanometer mirror that performs scanning in two directions, the X and Y axes.

The lens 17 is used to focus the light from the OCT light source 20 emitted from the fiber 21 onto the test eye Er, and is driven by a motor (not shown). By this focusing, the return light from the test eye Er is simultaneously focused into a spot-like image and incident on the tip of the fiber 21.

Furthermore, an optical coupler 19, an OCT light source 20, optical fibers 21 to 24 connected to and integrated with the optical coupler 19, a lens 25, dispersion compensation glass 26, a reference mirror 27, and a spectrometer 28 are arranged.

Light emitted from the OCT light source 20 via the optical fiber 22 is split into measurement light and reference light by the optical coupler 19. The measurement light is emitted toward the test eye Er through the optical fiber 21, the optical path L1 of the OCT optical system, and the objective lens 1. The measurement light emitted toward the test eye Er is reflected and scattered by the test eye Er and reaches the optical coupler 19 via the same path.

On the other hand, the reference light is emitted through the optical fiber 23, the lens 25, and the dispersion compensation glass 26 toward the reference mirror 27. The reference light reflected from the reference mirror 27 reaches the optical coupler 19 via the same optical path.

In this way, the measurement light and reference light that reach the optical coupler 19 are combined to become interference light. Here, interference occurs when the optical path length of the measurement light and the optical path length of the reference light become approximately the same. The reference mirror 27 is held adjustable in the optical axis direction by a motor and drive mechanism (not shown), making it possible to match the optical path length of the reference light to the optical path length of the measurement light, which changes depending on the test eye Er. The interference light is guided to the spectroscope 28 via the optical fiber 24.

The spectroscope 28 is composed of lenses 29 and 31, a diffraction grating 30, and a line sensor 32. The interference light emitted from the optical fiber 24 is converted into parallel light via the lens 29, then dispersed by the diffraction grating 30 and imaged on the line sensor 32 by the lens 31.

In this embodiment, an SLO optical system is used as the fundus observation system, but the fundus observation system is not limited to this as long as it is an optical system that can acquire a front image, and may be configured using, for example, a fundus camera.

In this embodiment, a Michelson interferometer is used as the interference system, but a Mach-Zehnder interferometer may also be used. Depending on the difference in light intensity between the measurement light and the reference light, it is desirable to use a Mach-Zehnder interferometer when the difference in light intensity is large, and a Michelson interferometer when the difference in light intensity is relatively small.

<Acquisition of First Image Data and Second Image Data>
The ophthalmological analysis apparatus 100 of this embodiment acquires first image data including a specified portion of the test eye, and second image data that is of a different type from the first image data and has position information associated with the first image data.

Examples of the first image data and the second image data include a case where the first image data is three-dimensional OCT motion contrast data and the second image data is three-dimensional OCT data that is the basis of the three-dimensional OCT motion contrast data, a case where the first image data is three-dimensional OCT data that is the basis of the three-dimensional OCT motion contrast data and the second image data is three-dimensional OCT motion contrast data, a case where the first image data is an OCT analysis map and the second image data is three-dimensional OCT data, a case where the first image data is a fluorescent fundus image and the second image data is three-dimensional OCT motion contrast data, a case where the first image data is three-dimensional OCT motion contrast data and the second image data is fluorescent fundus image data, and the like. In addition, although the OCT data that is the basis of the motion contrast data is described here, it may be data associated with the OCT data that is the basis of the motion contrast data. Here, the OCT motion contrast is, for example, a signal obtained from the time change of an OCT signal at a predetermined position, and is information that captures the blood flow state of the subject's eye, etc.

When either the first image data or the second image data is three-dimensional OCT data or three-dimensional OCT motion contrast data, for example, the ophthalmic analysis device 100 may control the subject's eye data acquisition device 600, process the detected OCT signal to acquire three-dimensional OCT data, and further process the three-dimensional OCT data to acquire three-dimensional motion contrast data. In other words, the ophthalmic analysis device 100 may control the subject's eye data acquisition device 600 to capture images, and process the three-dimensional OCT data to acquire three-dimensional motion contrast data.

When acquiring three-dimensional OCT data, the control unit 200 controls the driving of the XY scanner 16 to scan the measurement light over the area T on the fundus Ef shown in FIG. 3 (1).

In FIG. 3(1), the z-axis is the direction in which the measurement light travels, the x-axis is perpendicular to the z-axis and extends left-right across the subject's eye, and the y-axis is perpendicular to the z-axis and extends up-down across the subject's eye.

An example of a scanning method is shown in Figure 3 (2).

The control unit 200 scans the measurement light in the x direction along the scanning lines L1, L2, ..., Ln in the region T, and acquires an A-scan signal in the z direction at each scanning position. In this way, the measurement light is scanned (B-scan) in a direction (x direction in FIG. 3(1)) that intersects with the optical axis (z-axis) direction of the measurement light, thereby acquiring a B-scan image, which is a two-dimensional tomographic image. Furthermore, by changing the position of this B-scan in the y direction and scanning sequentially, the measurement light can also be scanned two-dimensionally in the xy directions.

The control unit 200 can obtain multiple OCT data sets at different times for the same position and process (calculate) the obtained OCT data sets to obtain OCT motion contrast data.

For example, the control unit 200 sequentially repeats multiple B-scans at different times on each of the scanning lines (scanning lines L1, L2, ..., Ln) to obtain multiple 2D OCT data on each scanning line and store them in the memory unit 3.

Then, multiple pieces of 2D OCT data acquired at different times for the same position are processed to obtain 2D OCT motion contrast data. This is then applied to all B-scan scanning lines to obtain 3D OCT motion contrast data.

Methods of processing OCT data to obtain OCT motion contrast data include, for example, a method using the phase difference of complex OCT data, a method using the vector difference of complex OCT data, a method using the intensity difference of complex OCT data, a method multiplying the phase difference and vector difference of complex OCT signals, a method using signal correlation, and the like, and any of these may be used.

<Display of First Two-Dimensional Image and Second Two-Dimensional Image>
The display control means of the control unit 200 displays on the display unit a first two-dimensional image included in the acquired first image data or a first two-dimensional image generated based on the first image data, and a second two-dimensional image included in the acquired second image data or a second two-dimensional image generated based on the second image data. That is, the control unit 200 may generate a two-dimensional image from the first image data to generate the first two-dimensional image, or may use a two-dimensional image included in the first image data as the first two-dimensional image, and the same applies to the second two-dimensional image.

For example, as shown in FIG. 4, the control unit 200 displays a first two-dimensional image 401 generated based on the first image data in a first display area 400 of the display unit 5, and displays a second two-dimensional image 501 generated based on the first image data in a second display area 500 on the display unit 5.

Here, it is preferable that the first two-dimensional image 401 and the second two-dimensional image 501 overlap at least in part in the area where the test eye data was acquired, and they may be completely identical.

Note that the first two-dimensional image 401 and the second two-dimensional image 501 may be displayed at different times, or may be displayed simultaneously.

The first two-dimensional image 401 may be a front image generated based on the first image data, and the second two-dimensional image 501 may be a front image generated based on the second image data.

For example, when the first or second image data is three-dimensional OCT motion contrast data, the first or second two-dimensional image generated based on the first or second image data may be an OCT front motion contrast image generated using an integrated value or a maximum value in at least a portion of the depth direction in the three-dimensional OCT motion contrast data.

In addition, when the first or second image data is three-dimensional OCT data, the first or second two-dimensional image may be an OCT front image generated using an integrated value or maximum value in the depth direction in the three-dimensional OCT data.

In addition, when the first or second image data is three-dimensional OCT motion contrast data, the first or second two-dimensional image generated based on the first or second image data may be an OCT motion contrast image that is reconstructed from the three-dimensional OCT motion contrast data and displayed in three dimensions. Similarly, when the first or second image data is three-dimensional OCT data, the first or second two-dimensional image may be an OCT image displayed in three dimensions.

Furthermore, if the first image data is two-dimensional data, the first two-dimensional image may be the first image data itself. Also, if the first image data is three-dimensional data, the first two-dimensional image may be an image included in the three-dimensional data.

Similarly, if the second image data is a two-dimensional image, the second two-dimensional image may be the second image data itself, or the second image data may be three-dimensional data and the second two-dimensional image may be an image included in the three-dimensional data.

Examples of two-dimensional images in which the first image data or the second image data is three-dimensional data and the first two-dimensional image or the second two-dimensional image is included in the three-dimensional data include a case in which the first image data or the second image data is three-dimensional OCT motion contrast data and the first two-dimensional image or the second two-dimensional image is an OCT motion contrast tomographic image, or a case in which the first image data or the second image data is three-dimensional OCT data and the first two-dimensional image or the second two-dimensional image is a two-dimensional OCT tomographic image.

When the first image data is an OCT analysis map, the first two-dimensional image included in the first image data or generated based on the first image data may be, for example, a color map that two-dimensionally represents the analysis results of the subject eye (e.g., a fundus layer thickness map, a map showing the fundus curvature distribution, etc.), that is, a map showing the two-dimensional distribution of the fundus-related measurement results. In this case, it may be, for example, a color map that is color-coded according to the measurement value.

The OCT analysis map may be, for example, a thickness map showing layer thickness, a comparison map showing the results of comparing the layer thickness of the test eye with the layer thickness of a normal eye stored in a normal eye database, or a deviation map showing the deviation between the layer thickness of the test eye and the layer thickness of a normal eye stored in a normal eye database by standard deviation. When determining the layer thickness, for example, the OCT data is divided into layers by image processing (e.g., segmentation processing) of the OCT data, and the thickness of each layer is measured based on the distance between the layer boundaries.

<Analysis processing>
The control unit 200 can set an analysis area in the second image data and perform analysis processing based on information regarding a first area included in the first image data or set on a first two-dimensional image generated based on the first image data.

For example, the operation reception unit receives an operation signal from the operation unit 40 using a region setting tool (not shown), and when the position and/or size of a region setting chart 404a consisting of multiple partial regions that can be set on the first two-dimensional image 401 displayed in the first display area 400 is specified as shown in FIG. 4, the control unit 200 superimposes the region setting chart 404a on the first two-dimensional image 401, and sets and superimposes an analysis chart 504a on the second two-dimensional image 501 displayed in the second display area 500 so as to correspond to the first region set in the region setting chart 404a. The control unit 200 can then set an analysis region in the second image data based on at least one region set by the analysis chart 504a, and perform analysis processing.

That is, the analysis chart 504a set on the second two-dimensional image 501 is an analysis chart for calculating the statistical values of the measurement results of the second image data in a pre-set area as the analysis result, and the area shown by the analysis chart 504a may be a single area, or may be composed of multiple partial areas (hereinafter referred to as sections) as shown in FIG. 4. When composed of multiple sections, the statistical values of the measurement results may be calculated for each divided section. The statistical values may be representative values (average value, median value, mode, maximum value, minimum value, etc.), dispersion (variance, standard deviation, coefficient of variation), etc.

The analysis chart 504a may also have a display area that displays statistical values in a specific area as the analysis results. Instead of displaying numerical values, the chart may be colored according to the measurement results on a section-by-section basis.

The position of the analysis chart 504a may be set based on information about the first region set by the region setting chart 404a on the first two-dimensional image 401, and the information about the first region may be information about the first region or information about the outer edge of the first region. For example, the analysis chart 504a may be set at a position on the second two-dimensional image 501 that corresponds to the position of the outer edge of the first region set by the region setting chart 404a superimposed on the first two-dimensional image 401, and the analysis region of the second image data may be set.

The size of the first area set in the first two-dimensional image 401 by the area setting chart 404a and the area set in the second two-dimensional image 501 by the analysis chart 504a may be different. For example, the position of the center position 504b of the analysis chart 504a on the second two-dimensional image 501 may be set based on the position of the center position 404c of the area setting chart 404a superimposed on the first two-dimensional image 401.

The operation reception unit of the control unit 200 may receive an operation signal from the operation unit 40 using a region setting tool (not shown), change the position of the region setting chart 404a superimposed on the first two-dimensional image 401, and in conjunction with this, change the position of the analysis chart 504a superimposed on the second two-dimensional image 501, thereby changing the position of the analysis region of the second image data.

For example, the examiner can operate the operation unit 40 to move the area setting chart 404a superimposed on the first two-dimensional image 401, thereby setting the center 404c of the area setting chart 404a to a reference site of the fundus (e.g., the center of the fovea, the center of the optic disc, an abnormal site). This allows the center 504c of the analysis chart 504a to be set to the reference site of the fundus, and an analysis result of the second image data centered on the reference site of the fundus can be obtained.

Furthermore, the control unit 200 can set the position of the analysis chart 504a superimposed on the second two-dimensional image 501 based on information about the first region set by the region setting chart 404a superimposed on the first two-dimensional image 401, and then change the position of the analysis chart 504a by accepting an operation signal from the operation unit 40.

In the explanation so far, the area setting chart 404a superimposed on the first two-dimensional image 401 has been used only to set the analysis area of the second image data, but it may also have the function of an analysis chart for setting the analysis area of the first image data, in which case the area setting chart 404a can also be expressed as an analysis chart 404a.

As shown in FIG. 4, when both the analysis chart 404a superimposed on the first two-dimensional image 401 and the analysis chart 504a superimposed on the second two-dimensional image 501 have multiple sections, the position and range of each of the multiple sections set by the analysis chart 404a can be configured to be identical to the position and range of each of the multiple sections in the second analysis region of the second image data set by the analysis chart 504a.

Here, the analysis chart 404a and the analysis chart 504a can be selected arbitrarily. For example, when the two-dimensional image to be superimposed is a thickness map near the macula, the analysis chart 404a and the analysis chart 504a can be selected from, for example, the GCHART, the S/I chart, and the ETDRS. Also, when the two-dimensional image to be superimposed is a thickness map near the optic disc, the analysis chart 504a can be selected from, for example, the whole chart, the top and bottom chart (2 divisions), the TSNIT chart (4 divisions), and the ClockHour chart (12 divisions).

When the data to be analyzed is three-dimensional OCT data, the control unit 200 may calculate statistical values of the layer thickness data for each section as the analysis result of the analysis chart. In this case, the layer thickness data may be the sum of each layer, or may be the thickness of a certain layer (e.g., the optic nerve fiber layer).

In addition, when the data to be analyzed is three-dimensional OCT motion contrast data, the control unit 200 may perform a process of distinguishing between vascular regions and non-vascular regions, extract the vascular regions through the discrimination process, and calculate an analysis result that measures the vascular regions.

The discrimination process may be, for example, a threshold process, in which pixels that satisfy the threshold are determined to be vascular regions and pixels that do not satisfy the threshold are determined to be non-vascular regions. The threshold itself may be arbitrarily set by the examiner, or may be determined in advance as a fixed value. The threshold may also be set through image analysis processing of the second two-dimensional image 501.

The analysis results may be, for example, blood vessel density or blood vessel area. For the density of the blood vessel region, for example, the ratio of the blood vessel region to the entire blood vessel analysis region is calculated to obtain the blood vessel area per unit area (blood vessel volume). The measurement results are not limited to this, and may be, for example, the total blood vessel volume.

When the first analysis region is divided into multiple sections, the control unit 200 may determine the ratio or difference of the analysis results between each section. This makes it possible to determine, for example, the symmetry of blood vessels.

In addition, with regard to blood vessel measurement, the control unit 200 may correct the measurement results according to the axial length value of the subject eye. This is because the OCT scanning range may differ depending on the axial length. In addition, the control unit 200 may distinguish and display vascular regions and non-vascular regions based on the results of the discrimination process, and may, for example, display vascular regions by coloring them.

In this way, by setting the analysis region of the second image data based on information about the first region set in the first two-dimensional image, even if the disease region is difficult to see in the two-dimensional image of the second image data, it is possible to identify the disease region in the first two-dimensional image and perform analysis processing of the second image data in the identified region.

<Follow-up>
When the second image data acquired by the ophthalmological analysis device 100 is the target data of a follow-up examination and an analysis area was not set in the analysis target data in the past examination, and a new analysis process is to be performed, the control unit 200 aligns the second two-dimensional image acquired in the past examination (hereinafter referred to as the second two-dimensional image of the past examination) with the second two-dimensional image acquired in the current examination (hereinafter referred to as the second two-dimensional image of the current examination), and sets the analysis chart at a position on the second two-dimensional image of the past examination that corresponds to the position of the analysis chart 504a set on the second two-dimensional image of the current examination.

On the other hand, if the second image data is the target data of a follow-up examination, an analysis area has been set on the data to be analyzed in a past examination, and analysis processing has been performed, the control unit 200 aligns the first two-dimensional image acquired in the past examination (hereinafter referred to as the first two-dimensional image of the past examination) with the first two-dimensional image acquired in the current examination (hereinafter referred to as the first two-dimensional image of the current examination), and sets the area setting chart 404a at a position on the first two-dimensional image of the current examination that corresponds to the position of the area setting chart set on the first two-dimensional image of the past examination.

After setting the area setting chart 404a on the first two-dimensional image of the current examination in this manner, it is also possible to change the position of the area setting chart 404a on the first two-dimensional image of the current examination by accepting instructions from the examiner through operation of the operation unit 40.

In addition, when analysis processing is performed on the first image data in addition to the second image data (i.e., when the area setting chart 404a functions as an analysis chart), statistical values of the analysis results for both data are calculated for each section of the analysis chart, and a display area for displaying the statistical values may be set and displayed in each section of the analysis chart 404a set on the first two-dimensional image and the analysis chart 504a set on the second two-dimensional image.

Furthermore, the control unit 200 can provide a selection instruction for the examiner to select at least one section in the analysis chart 404a superimposed on the first two-dimensional image and the analysis chart 504a superimposed on the second two-dimensional image, and generate time series data of both the first image data and the second image relating to the selected section and display the generated time series data.

As shown in FIG. 5, for example, the control unit 200 performs control to calculate statistical values of both the first image data and the second image data for the current test data and past test data for a section selected by the examiner in the instruction receiving GUI, and output the calculated values as time series data of the first image data and the second image data for the selected section. Note that in FIG. 5, the solid lines are examples of time series data of statistical values of the first image data for the selected section, and the dashed lines are examples of time series data of the second image data for the selected section. Sections may also be selected by the examiner checking check boxes for each section, as shown in FIG. 5.

The control unit 200 also allows the instruction receiving unit to receive an instruction from the examiner to specify one of at least two sections among the multiple sections of the analysis chart 404a superimposed on the first two-dimensional image and the analysis chart 504a superimposed on the second two-dimensional image, while the time series data of the first image data and the second image data are displayed.

When the instruction receiving unit receives an instruction, the control unit 200 performs control to display the first image data and the time series data of the second image data corresponding to a specified section in different display formats before and after receiving the instruction, or to display the first image data and the time series data of the second image data corresponding to all sections other than the specified section in different display formats before and after receiving the instruction.

The selection of at least two of the multiple sections of the analysis chart 404a superimposed on the first two-dimensional image and the analysis chart 504a superimposed on the second two-dimensional image may be performed after displaying the time series data of all sections of the analysis chart 404a superimposed on the first two-dimensional image and the analysis chart 504a superimposed on the second two-dimensional image, and the time series data to be displayed may be changed to only the time series data of the selected section, or at least two sections may be selected in advance and the time series data of the first image data and the second image data related to the selected section may be displayed.

Examples of displaying the time series data of the first image data and the second image data corresponding to the specified section in different display forms before and after the instruction receiving unit receives an instruction include highlighting the time series data of the selected section, displaying it in a specific color, making it bold, etc. Examples of displaying the time series data of the first image data and the second image data corresponding to all sections other than the specified section in different display forms before and after the instruction receiving unit receives an instruction include displaying it in thin text, displaying it in dashed lines, making it a lighter color, not displaying it, etc.

This allows the examiner to easily check changes over time in the analysis results of the first image data and the second image data relating to the section of interest to the examiner.

Example Hereinafter, an example of the analysis process of the ophthalmic analysis apparatus having the above-mentioned configuration will be described.

Example 1
The analysis process of this embodiment includes the following steps S11 to S16, as shown in the flow chart of FIG.

(Step S11)
The control unit 200 of the ophthalmic analysis device 100, for example, controls an OCT device to perform scanning on each of a plurality of lines to acquire a plurality of temporally different two-dimensional OCT data for the same position on the fundus of the subject eye to acquire three-dimensional OCT data, and performs arithmetic processing on the acquired three-dimensional OCT data to acquire three-dimensional OCT motion contrast data. Here, an example of actually controlling the OCT device to acquire data has been described, but data that has already been acquired, processed, and stored may also be read.

(Step S12)
The control unit 200 sets a depth range for the three-dimensional OCT motion contrast data acquired in step S11, calculates statistical values such as an integrated value or a maximum value of the three-dimensional OCT motion contrast data in the set depth range, and generates an OCT front motion contrast image 402, which is a two-dimensional image of the three-dimensional OCT motion contrast data, based on the calculated values. Then, the generated OCT front motion contrast image 402 is displayed in the first display area 400 of the display unit 5 as shown in FIG.

The control unit 200 also sets, for the three-dimensional OCT data acquired in step S11, a depth range that is the same as the depth range set for the three-dimensional motion contrast data, calculates statistical values such as an integrated value or a maximum value in the depth direction, and generates an OCT front image 502, which is a two-dimensional image of the three-dimensional OCT data, based on the calculated values. The generated OCT front image 502 is then displayed in the second display area 500 of the display unit 5.

In other words, the OCT front image 502 is a two-dimensional OCT front image (an image) generated from the three-dimensional OCT data that is the basis of the three-dimensional OCT motion contrast data that generates the OCT motion contrast image 402. Here, the depth range for calculating the OCT front image is set to be the same as the depth range set in the three-dimensional motion contrast data, but of course it is not limited to this and may be set to a different depth range.

(Step S13)
When the operation receiving unit receives an operation signal from the operation unit 40 operated by the examiner, the control unit 200 superimposes a region setting chart 404a on the OCT frontal motion contrast image 402 displayed in the first display area 400 (Figure 7), and sets a first region 404d in the OCT frontal motion contrast image 402 using the region setting chart 404a.

At this time, the position and size of the region setting chart 404a may be changed by the operation reception unit receiving an operation signal from the operation unit 40 by the examiner.

(Step S14)
The control unit 200 superimposes and displays the analysis chart 504a on the area on the OCT front image 502 that corresponds to the area (first area 404d) of the area setting chart 404a on the OCT front motion contrast image 402 set in step S13. The analysis chart 504a may be one area or may have multiple sections as shown in FIG.

Then, the control unit 200 sets the area set in the 3D OCT data by the analysis chart 504a as the first analysis area. In other words, the first analysis area is the 3D OCT data analysis area.

In FIG. 7, the region setting chart 404a and the analysis chart 504a on the OCT front motion contrast image 402 are the same size, but the region setting chart 404a and the analysis chart 504a may be different sizes, and the center position of the analysis chart 504a on the OCT front image 502 may be set based on the center position of the region setting chart 404a on the OCT front motion contrast image 402, and an analysis region may be set in the 3D OCT data by a region set on the OCT front image 502 by the analysis chart 504a of a size different from that of the region setting chart 404a. Also, the size of the analysis chart 504a may be set or corrected at this stage, in which case it may be done according to instructions from the examiner.

In addition, the control unit 200 can change the position of the analysis chart 504a on the OCT front image 502 in response to a change in the display position of the area setting chart 404a on the OCT motion contrast image 402, and perform control to change the position of the analysis area on the three-dimensional OCT data.

(Step S15)
The control unit 200 performs an analysis process on the analysis region of the three-dimensional OCT data set in step S14.

When the analysis region has multiple sections set by an analysis chart, the analysis process of the 3D OCT data may calculate the analysis results for each section, or may calculate statistical values of the analysis results for each section. The statistical values may be representative values (average, median, mode, maximum, minimum, etc.), dispersion (variance, standard deviation, coefficient of variation), etc. A suitable example of a statistical value of the 3D OCT data is the average layer thickness. When calculating the average layer thickness, the layer thickness is calculated by setting layer boundaries by segmenting the 3D OCT data.

(Step S16)
The control unit 200 displays the results of the analysis process performed in step S15 on the display unit 5. At this time, the results of the analysis process may be displayed within the display area of each section of the analysis chart 504a.

In this embodiment, in step S13, a first region 404d is set in the OCT front motion contrast image 402 based on the region setting chart 404a superimposed on the OCT front motion contrast image 402.

However, if a region setting chart 404a superimposed on the OCT front motion contrast image 402 has been set in a previous examination of the follow-up examination, the control unit 200 aligns the OCT front motion contrast image in the previous examination with the OCT front motion contrast image in the current examination, and sets the region setting chart 404a as the initial position at a position in the OCT front motion contrast image of the current examination that corresponds to the position of the region setting chart 404a in the OCT front motion contrast image of the previous examination. At this time, it is also possible to change the position of the region setting chart 404a from the initial position by receiving an instruction from the examiner.

Then, similarly to steps S13 to S15, the control unit 200 superimposes the analysis chart 504a at a position on the OCT front image 502 of the current examination that corresponds to the position of the region setting chart 404a set on the OCT front motion contrast image 402 of the current examination, and sets the region of the 3D OCT data set by the analysis chart 504a as the first analysis region.

(Step S17)
The control unit 200 calculates statistical values of the analysis regions of the 3D OCT data corresponding to the multiple sections of the analysis chart 504a, and outputs them as time series data based on the calculated statistical values and the statistical values for each section of the 3D OCT data calculated in past examinations.

As a result, diseased areas such as those with blood flow disorders can be identified in the OCT frontal motion contrast data 402, and the area of the 3D OCT data corresponding to that area or an area including that area can be set as the analysis area, and time series data of the analysis processing of the 3D OCT data can be output.

Example 2
In Example 2, an example is described in which in step S13 of Example 1, the first region 404d set in the three-dimensional OCT motion contrast data, which is the first image data, is set as the first analysis region, and the first analysis region set in the three-dimensional OCT data, which is the second image data, is set as the second analysis region, and analysis processing is performed.

The following describes the first analysis region set in the 3D OCT motion contrast data in this embodiment and its analysis process, focusing on the differences from Example 1. Note that in this embodiment, descriptions of parts that are similar to Example 1 will be omitted.

(Step S21)
Similar to step S11 in Example 1, the control unit 200 controls the OCT device to acquire time-varying three-dimensional OCT data for the same position, and performs arithmetic processing on the acquired three-dimensional OCT data to acquire three-dimensional OCT motion contrast data.

(Step S22)
Similar to step S12 in the first embodiment, the control unit 200 generates an OCT front image 502 based on the three-dimensional OCT data acquired in step S21, and displays it in the second display area 500. The control unit 200 also generates an OCT front motion contrast image 402 based on the three-dimensional OCT motion contrast data acquired in step S21, and displays it in the first display area 400.

(Step S23)
As in step S13 in the first embodiment, the control unit 200 superimposes an analysis chart 404a (hereinafter, also referred to as a first analysis chart 404a) on the OCT front motion contrast image 402 as shown in Fig. 8 by receiving an operation signal from the operation unit 40 operated by the examiner via the operation reception unit, and sets a first analysis region (three-dimensional OCT motion contrast data analysis region) in the three-dimensional OCT motion contrast data acquired by the OCT device. At this time, the operation reception unit may receive an operation signal from the operation unit 40 for changing the position or size of the first analysis chart 404a.

Here, in this step, the first analysis chart 404a not only functions as a region setting chart for setting the first analysis region of the three-dimensional OCT data described in Example 1, but also functions as an analysis chart for setting the analysis region of the three-dimensional OCT motion contrast data.

In addition, in step S13 of Example 1, the region setting chart 404a sets one region, but in this step, the first analysis chart 404a has multiple sections, and the regions of the 3D OCT motion contrast data corresponding to each section are set as analysis regions that constitute the first analysis region.

The corresponding area in the 3D OCT motion contrast data is set as the first analysis area.

The control unit 200 sets the area of the 3D OCT motion contrast data that corresponds to the area of the OCT frontal motion contrast image 402 set by the analysis chart 404a as the first analysis area.

As in step S16, if this embodiment is a follow-up examination and a first analysis region is set in the three-dimensional OCT motion contrast data in the past examination and a second analysis region is set in the three-dimensional OCT data, the control unit 200 aligns the OCT front motion contrast image in the past examination with the OCT front motion contrast image in the current examination, and superimposes and displays the first analysis chart 404a with the position of the OCT front motion contrast image of the current examination corresponding to the position of the first analysis chart in the OCT front motion contrast image of the past examination as the initial position.

Then, the position of the set first analysis chart 404a may be changed by the operation reception unit receiving an operation signal from the operation unit 40, and accordingly, the first analysis region of the 3D OCT motion contrast data in the past examination and the current examination may be changed.

(Step S24)
The control unit 200 superimposes a second analysis chart 504a at a position on the OCT frontal image 502 corresponding to the position of the first analysis chart 404a on the OCT frontal motion contrast data 402 set in step S23, and sets the area of the three-dimensional OCT data set by the second analysis chart 504a as the second analysis area (three-dimensional OCT data analysis area).

In other words, as shown in FIG. 8, the second analysis chart 504a has multiple sections whose positions and ranges are the same as those of the first analysis chart 404a, so the area of the 3D OCT data corresponding to the partial area specified by each section of the first analysis chart 404a is set as the second analysis area.

Therefore, in this embodiment, each partial area of the first analysis area of the three-dimensional motion contrast data set in step S23 and each partial area of the second analysis area of the three-dimensional OCT data are set as the same area in the test eye.

In addition to the above, a method of setting the second analysis region in the current three-dimensional OCT data in the follow-up examination may be to align the OCT front image in the past examination with the OCT front image in the current examination, and to set the second analysis region by superimposing the second analysis chart 504a at the same position on the OCT front image of the current examination as the position on the OCT front image corresponding to the analysis region of the three-dimensional OCT data of the past examination. Here, if the position of the second analysis chart 504a set based on the first analysis chart 404a on the current OCT front motion contrast image 402 differs from the position of the second analysis chart 504a set based on the second analysis chart on the past OCT front image, a warning may be displayed, and the examiner may select which method to use to set the position of the second analysis region.

(Step S25)
The control unit 200 performs an analysis process on the first analysis region set in the three-dimensional OCT motion contrast data in step S23, and on the second analysis region set in the three-dimensional OCT data in step S24.

At this time, the control unit 200 calculates statistical values for each section of the first analysis region and the second analysis region as an analysis process for each of the 3D OCT motion contrast data and the 3D OCT data. The statistical values may be representative values (average value, median value, mode, maximum value, minimum value, etc.), dispersion (variance, standard deviation, coefficient of variation), etc. An example of the statistical value of the 3D OCT data is the average layer thickness, and an example of the statistical value of the 3D OCT motion contrast data is the blood vessel density or blood vessel area. The blood vessel density can be calculated by calculating the ratio of the area (or length) of the blood vessel region to the entire blood vessel analysis region.

(Step S26)
The control unit 200 displays the calculation results of the statistical values for each section, calculated in step S25, for the first analysis region of the three-dimensional OCT motion contrast data and the second analysis region of the three-dimensional OCT data, on the display unit 5. At this time, the results of the analysis process may be displayed within the areas of each section of the first analysis chart 404a and the second analysis chart 504a.

(Step S27)
The instruction receiving unit receives an instruction from the examiner to select at least one of the multiple sections of the first analysis chart 404a superimposed on the OCT frontal motion contrast image 402 in the first display area 400 of the display unit 5, and the second analysis chart 504a superimposed on the OCT frontal image 502 in the second display area 500, as shown in Figure 8.

The examiner can select a section by, for example, preparing an instruction receiving GUI 51 that combines check boxes with icons that visually display each of the multiple sections in the first analysis chart 404a and the second analysis chart 504a as shown in FIG. 5, and checking the boxes provided for each section. In FIG. 5, one section in the first quadrant region near the center is selected.

(Step S28)
In the case of a follow-up examination, the control unit 200 performs display control to calculate and display time series data of the selected section of the 3D OCT motion contrast data and the 3D OCT data based on the statistical values of the section specified in step S27 of the 3D OCT motion contrast data and the 3D OCT data in the past examination and the statistical values of the selected section in the statistical values for each section calculated in step S26. In Fig. 5, the time series data of the statistical values of the 3D OCT motion contrast data in the section of the first quadrant region near the center selected by the instruction receiving GUI 51 in step S27 (e.g., time series change in blood vessel density) is plotted as a solid line, and the time series data of the statistical values of the 3D OCT data (e.g., time series change in average layer thickness) is plotted as a dotted line in the graph display area 52.

This allows only the 3D OCT motion contrast data and analysis results of the 3D OCT data related to the section of interest to the examiner to be displayed as time-series data such as a time-series graph, allowing the examiner to easily check or compare changes over time in the desired area.

Example 3
In a third embodiment, an example will be described in which the first image data in the second embodiment is three-dimensional OCT data, and the second image data is three-dimensional OCT motion contrast data.

(Step S31)
Similar to step S11 in Example 1, the control unit 200 controls the OCT device to perform scanning on each of the multiple lines to obtain multiple two-dimensional OCT data that are temporally different for the same position, thereby obtaining three-dimensional OCT data, and then performs arithmetic processing on the obtained OCT data to obtain three-dimensional OCT motion contrast data.

(Step S32)
Similar to step S12 in the first embodiment, the control unit 200 generates an OCT front image 502 based on the three-dimensional OCT data acquired in step S31, and displays it in the first display area 400. Also, similar to step S12 in the first embodiment, the control unit 200 generates an OCT front motion contrast image 402 based on the three-dimensional OCT motion contrast data acquired in step S31, and displays it in the second display area 500.

(Step S33)
In step S23 of the second embodiment, the control unit 200 sets the first analysis region in the three-dimensional OCT motion contrast data, but in the present embodiment, the control unit 200 sets the first analysis region in the three-dimensional OCT data.

As shown in FIG. 9, when the operation reception unit receives an operation signal from the operation unit 40 operated by the examiner, a first analysis chart 404a having multiple sections is superimposed on the OCT front image 502 displayed in the first display area 400, and an area on the 3D OCT data corresponding to the area on the OCT front image 502 set by the first analysis chart 404a is set as the first analysis area (3D OCT data analysis area).

At this time, the operation reception unit may receive an operation signal from the operation unit 40 for changing the position or size of the first analysis chart 404a, as in the second embodiment.

Note that, if this embodiment is a follow-up examination and a first analysis region has been set in the 3D OCT data in a past examination, similar to step S23, the OCT front image in the past examination is aligned with the OCT front image in the current examination, and the first analysis chart 404a is superimposed and displayed with the position of the OCT front image in the current examination corresponding to the position of the analysis chart on the OCT front image of the past examination as the initial position. The position of the set first analysis chart 404a may be changed by the operation reception unit receiving an operation signal from the operation unit 40, and the first analysis region in the past examination and the current examination may be changed, similar to embodiment 2.

(Step S34)
The control unit 200 superimposes and displays the second analysis chart 504a at a position on the OCT en face motion contrast image 402 corresponding to the position of the first analysis chart 404a on the OCT en face image 502 set in step S33.

Then, the control unit 200 sets the area set in the 3D OCT motion contrast data by the second analysis chart 504a as the second analysis area (3D OCT motion contrast data analysis area).

Therefore, in this embodiment, the first analysis region set in the 3D OCT data in step S33 and the second analysis region set in the 3D OCT motion contrast data are set as the same region of the test eye.

In this embodiment, similarly to step S23, the second analysis chart 504a has multiple sections whose placement positions and ranges are identical to those of the first analysis chart 404a, and the second analysis region is set by setting the region of the 3D OCT motion contrast data corresponding to the partial region specified by each section as the analysis region.

(Step S35)
The control unit 200 performs analysis processing of the first analysis region set in the three-dimensional OCT data in step S33 and the second analysis region set in the three-dimensional OCT motion contrast data in step S34 in the same manner as step S25 in Example 2, and calculates statistical values for each section of the first analysis region set in the three-dimensional OCT data and the second analysis region set in the three-dimensional OCT motion contrast data.

(Step S36)
The control unit 200 displays on the display unit 5 the calculation results of the statistical values for each section calculated in step S35 for the first analysis region of the three-dimensional OCT motion contrast data and the second analysis region of the three-dimensional OCT data.

(Step S37)
The instruction receiving unit receives an instruction from the examiner to select at least two of a plurality of sections included in the first analysis chart 404a superimposed on the OCT front image 502 in the first display area 400 and the second analysis chart 504a superimposed on the OCT front motion contrast image 402 in the second display area 500, by checking the check boxes of the instruction receiving GUI 51, as in the second embodiment. At this time, it is preferable that the selection of the section is performed by selecting one of the first analysis chart 404a and the second analysis chart 504a.

(Step S38)
In this step, similar to step S28 in Example 2, the control unit 200 performs control to calculate and display time series data based on the statistical values for the section selected in step S37 of the 3D OCT motion contrast data and the 3D OCT data in past examinations, and the statistical values for the specified section of the 3D OCT motion contrast data and the 3D OCT data calculated in step S36; this process will be described in conjunction with the next step 39 using Figures 10 and 11.

In FIG. 10, the section in the first quadrant near the center, which is designated to be plotted as a circle in the instruction receiving GUI 51, and the section in the fourth quadrant near the center, which is designated to be plotted as a square, are selected, so that in the graph display area 52, the statistical values of the three-dimensional OCT motion contrast data (e.g., time series changes in blood vessel density) in each section are plotted as two solid lines, and the statistical values of the three-dimensional OCT data (e.g., time series changes in average layer thickness) are plotted as two dotted lines. Here, since the examiner has not yet given an instruction to further specify one of the at least two sections selected by the examiner in step S39 (the specific content of which will be described later), the graph is not highlighted, and the elements plotted as four lines are similarly plotted without filling and are displayed as thin lines.

(Step S39)
In step S37, the instruction receiving unit receives an instruction from the examiner to further specify one of the at least two sections selected by the examiner. In this embodiment, this specification is performed by moving a pointer 53 operated by a pointing device such as a mouse onto the section to be specified on the instruction receiving GUI 51.

When the pointer 53, which in FIG. 10 was placed outside the reception GUI 51, is moved onto a section in the first quadrant near the center of the GUI 51, which is a section plotted as a circle as shown in FIG. 11, the control unit 200 detects that the section has been designated and highlights that section of the GUI 51 by coloring it to indicate the designation, and switches the corresponding two circular plot lines to a highlighted display, for example by filling in the plot, thickening the line, or highlighting the line.

In this embodiment, the control unit 200 performs display control such that the time series data of the three-dimensional motion contrast data and the time series data of the three-dimensional OCT data relating to one specified section are displayed in different formats before and after the instruction receiving unit receives a specified instruction from the examiner.

Example 4
In a fourth embodiment, a case where the first image data in the third embodiment is a fluorescent fundus image will be described.

(Step S41)
The control unit 200 acquires the three-dimensional OCT data and the three-dimensional OCT motion contrast data in the same manner as in step S11. The control unit 200 also intravenously injects a fluorescent contrast agent into the subject and acquires a fluorescent contrast fundus image by a fundus camera, which is a fundus observation system included in the OCT device 6.

(Step S42)
The control unit 200 generates an OCT front motion contrast image 402 based on the three-dimensional OCT motion contrast data acquired in step S41, and displays it in the second display area 500, similar to step S12.

The control unit 200 also displays the fluorescent fundus image 602 acquired in step S41 in the first display area 400.

(Step S43)
Similar to step S33 in Example 3, the control unit 200 superimposes a first analysis chart 404a having multiple sections on the fluorescent fundus image 602 acquired in step S41, as shown in FIG. 12, and sets the area of the fluorescent fundus image 602 set by the first analysis chart 404a as the first analysis area.

At this time, the operation reception unit may receive an operation signal from the operation unit 40 to change the position or size of the first analysis chart 404a.

Note that, if this embodiment is a follow-up examination and a first analysis region was set in the fluorescent fundus image in the past examination, the fluorescent fundus image in the past examination is aligned with the fluorescent fundus image in the current examination, as in step S33, and the first analysis chart 404a is superimposed and displayed with the position of the fluorescent fundus image in the current examination corresponding to the position of the analysis chart on the fluorescent fundus image in the past examination as the initial position. The position of the set first analysis chart 404a may also be changed by the operation reception unit receiving an operation signal from the operation unit 40, changing the first analysis region in the past examination and the current examination, as in the third embodiment.

(Step S44)
The control unit 200 superimposes and displays the second analysis chart 504a at a position on the OCT en face motion contrast image 402 that corresponds to the position of the first analysis chart 404a on the fluorescent fundus image 602, which was set in step S43.

Then, the control unit 200 sets the area set in the 3D OCT motion contrast data by the second analysis chart 504a as the second analysis area.

At this time, similar to step S34, since the second analysis chart 504a has multiple sections with the same arrangement, position, and range as each section of the first analysis chart 404a, the area of the 3D OCT motion contrast data corresponding to the partial area specified by each section is set as the analysis area, and the second analysis area is set.

(Step S45)
The control unit 200 performs analysis processing on the first analysis region set in the fluorescent fundus image 602 in step S43 and the second analysis region set in the three-dimensional OCT motion contrast data in step S44, and calculates statistical values for each section of the first analysis region set in the fluorescent fundus image 602 and the second analysis region set in the three-dimensional OCT motion contrast data. An example of the statistical value of the fluorescent fundus image is blood vessel density.

(Step S46)
The control unit 200 displays on the display unit 5 the calculation results of the statistical values for each section for the first analysis region of the fluorescent fundus image 602 and the second analysis region of the three-dimensional OCT motion contrast data, calculated in step S45.

(Steps S47 to S49)
In steps S37 to S39 of Example 3, the control unit 200 performs control when the three-dimensional OCT data is converted into a fluorescent fundus image, and the examiner further specifies one of the at least two sections selected by the examiner, and performs display control such that the time series data of the three-dimensional motion contrast data and the time series data of the fluorescent fundus image relating to the specified section are displayed in different forms before and after the instruction receiving unit receives the specification instruction from the examiner.

Reference Signs List 100 Ophthalmic analysis device 200 Control unit 300 Storage unit 40 Operation unit 50 Display unit 51 Instruction reception GUI
52 Graph display area 53 Pointer 400 First display area 401 First two-dimensional image 404a Area setting chart or analysis chart 404c Center of area setting chart or analysis chart 404a 404d First area 500 Second display area 501 Second two-dimensional image 504a Analysis chart 504c Center of analysis chart 504a 600 Subject's eye data acquisition device 602 Fluorescent fundus image

Claims (17)

An ophthalmologic analysis device for analyzing data of a subject's eye acquired by an optical coherence tomography, comprising:
a subject's eye data acquiring means for acquiring first image data of the subject's eye acquired in an examination on a first examination date, and second image data different in type from the first image data and corresponding to the first image data;
a two-dimensional image acquiring means for acquiring a two-dimensional image based on the image data acquired by the subject's eye data acquiring means ;
and an analysis region setting means for setting an analysis region of the second image data based on a position on a first two-dimensional image based on third image data acquired in an examination on a second examination date different from the first examination date, the third image data being image data of the same type as the first image data;
An ophthalmic analysis device, characterized in that one of the first image data, the third image data, and the second image data is OCT data, and the other is OCT motion contrast data. The analytical region setting means sets an analytical region of the second image data based on a position on a first two-dimensional image based on third image data that is acquired in an examination on a second examination date different from the first examination date and is the same type of image data as the first image data.
The ophthalmological analysis device of claim 1, characterized in that a first area is set in a second two-dimensional image based on the first image data based on a position on a first two-dimensional image based on the third image data, and an analysis area of the second image data is set based on information regarding the first area. The ophthalmic analysis device,
A display control means for controlling display on the display means;
An instruction receiving means for receiving an instruction from an operator,
the display control means displays, as an initial position, an analysis chart indicating an analysis region of the second image data set by the analysis region setting means on a second two-dimensional image based on the first image data displayed on the display means;
3. The ophthalmic analysis apparatus according to claim 2, wherein the instruction receiving means receives an instruction to change the position of the analysis chart from the initial position. The ophthalmic analysis device according to any one of claims 1 to 3, characterized in that the first image data and the third image data are OCT data, and the second image data is OCT motion contrast data. The ophthalmic analysis device according to claim 4, characterized in that the first two-dimensional image is an OCT front image. The ophthalmic analysis device according to claim 4, characterized in that the first two-dimensional image is an analysis map of the OCT data. The ophthalmic analysis device according to claim 6, characterized in that the analysis map of the OCT data is one of a thickness map showing the layer thickness of the test eye, a comparison map between the layer thickness of the test eye and layer thicknesses stored in a normal eye database, and a deviation map showing the deviation between the layer thickness of the test eye and layer thicknesses stored in a normal eye database by standard deviation. The ophthalmic analysis device according to any one of claims 1 to 3, characterized in that the first image data and the third image data are OCT motion contrast data, and the second image data is OCT data. The ophthalmic analysis device according to claim 8, characterized in that the first two-dimensional image is an OCT frontal motion contrast image. The ophthalmological analysis device according to any one of claims 1 to 9, characterized in that the second examination date is an examination date that precedes the first examination date. The ophthalmological analysis device according to any one of claims 1 to 9, characterized in that the first examination date is an examination date that precedes the second examination date. The ophthalmic analysis device according to any one of claims 1 to 11, characterized in that the first image data and the second image data are three-dimensional image data. An ophthalmologic analysis device for analyzing data of a subject's eye acquired by an optical coherence tomography, comprising:
A subject's eye data acquisition means for acquiring OCT data of the subject's eye and OCT motion contrast data corresponding to the OCT data;
an OCT front image acquisition means for acquiring an OCT front image based on the OCT data;
an analysis region setting means for setting an analysis region of the OCT motion contrast data;
having
An ophthalmologic analysis apparatus characterized in that the analysis region setting means sets the analysis region of the OCT motion contrast data based on a position on an OCT front image based on OCT data acquired in a previous examination. The analysis region setting means sets an analysis region of the OCT motion contrast data based on a position on an OCT front image based on OCT data acquired in a past examination.
The ophthalmic analysis device of claim 13, characterized in that a first region is set in a second OCT front image, which is the OCT front image acquired by the OCT front image acquisition means, based on a position on a first OCT front image, which is an OCT front image based on OCT data acquired in the previous examination, and an analysis region of the OCT motion contrast data is set based on information regarding the first region. A method for analyzing test subject eye data acquired by an optical coherence tomography, comprising:
a test eye data acquiring step of acquiring first image data of the test eye acquired in an examination on a first examination date, and second image data different in type from the first image data and corresponding to the first image data;
a two-dimensional image acquiring step of acquiring a two-dimensional image based on the image data acquired by the subject's eye data acquiring step ;
and an analysis region setting step of setting an analysis region of the second image data based on a position on the first two-dimensional image based on third image data acquired in an examination on a second examination date different from the first examination date, the third image data being image data of the same type as the first image data,
A method for analyzing test eye data, characterized in that one of the first image data, the third image data, and the second image data is OCT data, and the other is OCT motion contrast data. A method for analyzing test subject eye data acquired by an optical coherence tomography, comprising:
A test eye data acquisition step of acquiring OCT data of the test eye and OCT motion contrast data corresponding to the OCT data;
an OCT front image acquisition step of acquiring an OCT front image based on the OCT data;
An analysis region setting step of setting an analysis region of the OCT motion contrast data;
having
A method for analyzing data of a test eye, characterized in that the analysis area setting process is a process of setting an analysis area of the OCT motion contrast data based on a position on an OCT frontal image based on OCT data obtained in a previous examination. An ophthalmic analysis program capable of executing the method for analyzing subject eye data according to claim 15 or 16 on an ophthalmic analysis device.

Images