JP7477844B2 - 免疫調節剤を含む徐放性医薬組成物およびその使用 - Google Patents
免疫調節剤を含む徐放性医薬組成物およびその使用 Download PDFInfo
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- JP7477844B2 JP7477844B2 JP2021521380A JP2021521380A JP7477844B2 JP 7477844 B2 JP7477844 B2 JP 7477844B2 JP 2021521380 A JP2021521380 A JP 2021521380A JP 2021521380 A JP2021521380 A JP 2021521380A JP 7477844 B2 JP7477844 B2 JP 7477844B2
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- lipid
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- fingolimod
- phosphate
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- FVJZSBGHRPJMMA-UHFFFAOYSA-N distearoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-UHFFFAOYSA-N 0.000 description 1
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- QSHQBWBFNCFHLO-MFABWLECSA-M sodium;(2s)-2-azaniumyl-3-[[(2r)-2,3-di(tetradecanoyloxy)propoxy]-oxidophosphoryl]oxypropanoate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OC[C@H]([NH3+])C([O-])=O)OC(=O)CCCCCCCCCCCCC QSHQBWBFNCFHLO-MFABWLECSA-M 0.000 description 1
- FGGPAWQCCGEWTJ-UHFFFAOYSA-M sodium;2,3-bis(sulfanyl)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(S)CS FGGPAWQCCGEWTJ-UHFFFAOYSA-M 0.000 description 1
- QLNOOKSBAYIHQI-SKZICHJRSA-M sodium;2,3-dihydroxypropyl [(2r)-2,3-di(tetradecanoyloxy)propyl] phosphate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCC QLNOOKSBAYIHQI-SKZICHJRSA-M 0.000 description 1
- BMBWFDPPCSTUSZ-MGDILKBHSA-M sodium;[(2r)-2,3-di(hexadecanoyloxy)propyl] hydrogen phosphate Chemical compound [Na+].CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)([O-])=O)OC(=O)CCCCCCCCCCCCCCC BMBWFDPPCSTUSZ-MGDILKBHSA-M 0.000 description 1
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Classifications
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862746810P | 2018-10-17 | 2018-10-17 | |
| US62/746,810 | 2018-10-17 | ||
| PCT/US2019/056186 WO2020081485A1 (en) | 2018-10-17 | 2019-10-15 | Sustained-release pharmaceutical compositions comprising an immunomodulating agent and uses thereof |
Publications (3)
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| JP2022505378A JP2022505378A (ja) | 2022-01-14 |
| JP2022505378A5 JP2022505378A5 (enExample) | 2022-09-12 |
| JP7477844B2 true JP7477844B2 (ja) | 2024-05-02 |
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| JP2016518340A (ja) | 2013-03-15 | 2016-06-23 | タイワン リポソーム カンパニー リミテッド | 水性及び非水性区画の両方におけるリポソーム組成物による制御薬物放出プロファイルの操作 |
| WO2017123588A1 (en) | 2016-01-11 | 2017-07-20 | Merrimack Pharmaceuticals, Inc. | Inhibiting ataxia telangiectasia and rad3-related protein (atr) |
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| IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| LT3173073T (lt) | 2004-05-03 | 2025-01-10 | Ipsen Biopharm Ltd. | Liposomos, skirtos vaistų pristatymui |
| CN101199505B (zh) * | 2007-12-20 | 2012-05-23 | 沈阳药科大学 | 维拉帕米脂质体及其制备方法 |
| CN101756902B (zh) * | 2008-12-23 | 2011-10-05 | 上海医药工业研究院 | 一种可乐定多囊脂质体及其制备方法 |
| CN101601654B (zh) * | 2009-07-03 | 2010-08-18 | 王明 | 盐酸法舒地尔脂质体注射剂及其新应用 |
| CN102406606B (zh) * | 2011-11-29 | 2013-01-23 | 海南美大制药有限公司 | 富马酸喹硫平脂质体固体制剂 |
| US20150157610A1 (en) * | 2012-05-23 | 2015-06-11 | Osaka University | Pharmaceutical composition for treating inflammatory disease |
| CN106999419A (zh) * | 2014-08-04 | 2017-08-01 | 佐尼奥尼制药股份有限公司 | 远程装载略微水溶性药物至脂质膜泡 |
| WO2016191547A1 (en) * | 2015-05-26 | 2016-12-01 | Comfort Care For Animals Llc | Liposome loading |
| EP4218739A3 (en) * | 2016-01-08 | 2023-08-09 | The Regents of The University of California | Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery |
| WO2019082139A1 (en) * | 2017-10-27 | 2019-05-02 | Shilpa Medicare Limited | LIPOSOMAL FINGOLIMOD HYDROCHLORIDE INJECTION |
| CN108354904A (zh) * | 2018-05-21 | 2018-08-03 | 天津双硕医药科技有限公司 | 一种含有盐酸金刚烷胺的口服药物组合物 |
| WO2020023445A1 (en) * | 2018-07-24 | 2020-01-30 | Taiwan Liposome Co., Ltd. | Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating dementia and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016513655A (ja) | 2013-03-13 | 2016-05-16 | マリンクロッド エルエルシー | 修飾されたドセタキセルリポソーム製剤 |
| JP2016518340A (ja) | 2013-03-15 | 2016-06-23 | タイワン リポソーム カンパニー リミテッド | 水性及び非水性区画の両方におけるリポソーム組成物による制御薬物放出プロファイルの操作 |
| WO2017123588A1 (en) | 2016-01-11 | 2017-07-20 | Merrimack Pharmaceuticals, Inc. | Inhibiting ataxia telangiectasia and rad3-related protein (atr) |
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| MAO Y. et al.，A novel liposomal formulation of FTY720 (Fingolimod) for promising enhanced targeted delivery，Nanomedicine. Author Manuscript, NIH Public Access，2014年08月16日，pp.1-19 |
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| TWI767149B (zh) | 2022-06-11 |
| EP3866764A1 (en) | 2021-08-25 |
| US12274785B2 (en) | 2025-04-15 |
| WO2020081485A1 (en) | 2020-04-23 |
| TW202033184A (zh) | 2020-09-16 |
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