JP7465503B2 - Method for determining the effectiveness of herbal medicine for a disease - Google Patents
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Description
本発明は、漢方薬の疾患に対する有効性の判定方法に関する。 The present invention relates to a method for determining the effectiveness of a herbal medicine for a disease.
西洋医学の治療は原因療法あるいは対処療法である。病気の原因を除去するのが原因療法であり、原因が不明の場合は鎮痛剤を投与するのが対処療法である。漢方医学では、患者の状態全体から症状を把握する。病気は一つの臓器のものではなく体全体に影響を及ぼすものとして、全体的に判断する点に特徴がある。 Western medical treatments are either causal or symptomatic. Causal treatment involves removing the cause of the illness, while symptomatic treatment involves administering painkillers when the cause is unknown. In traditional Chinese medicine, symptoms are understood from the patient's overall condition. It is characterized by its holistic approach, in that illness is not something that affects a single organ, but rather something that affects the entire body.
漢方薬は平成18年(2006年)施行の第十五日本薬局方に収載されて以降、局方の改正・追補毎に追加収載されてきた(非特許文献１)。また、1967年より漢方薬は薬価に収録され、保険適用の対象となった。漢方薬には西洋医薬に見られない特徴がある。漢方薬に対する保険適用の拡大・普及のためにも、漢方薬の評価に対するニーズは大きい。 Since being included in the 15th Japanese Pharmacopoeia, which came into effect in 2006, herbal medicines have been added to the list with each revision and supplement of the Pharmacopoeia (Non-Patent Document 1). Furthermore, since 1967, herbal medicines have been included in drug prices and have become eligible for insurance coverage. Herbal medicines have characteristics not found in Western medicine. There is a great need for evaluation of herbal medicines, in order to expand and popularize insurance coverage for herbal medicines.
しかし、漢方薬は複数の生薬を含有し、その生薬も複数の化合物を有効成分として含有しているため、漢方薬に含まれる多数の化合物を特定してその薬理薬効をそれぞれ測定し漢方薬を評価する作業は困難を極める。 However, herbal medicines contain multiple herbal medicines, and these herbal medicines themselves contain multiple compounds as active ingredients, making it extremely difficult to identify the numerous compounds contained in the herbal medicine, measure the pharmacological efficacy of each, and evaluate the herbal medicine.
経絡は、古代中国の医学において、人体の中の気血栄衛(代謝物質)の通り道として考え出されたものである。経は経脈を、絡は絡脈を表し、経脈は縦の脈、絡脈は横の脈を意味する。経脈は十二の正経と呼ばれるものと、八の奇経と呼ばれるものがある。正経は陰陽で分類され、陰は太陰、少陰、厥陰の三陰に、陽は太陽、陽明、少陽の三陽に分けられ、手、足それぞれに三陽三陰の属する経脈が割り振られて計十二脈になる。 Meridians were conceived in ancient Chinese medicine as the pathways through which Qi, blood, nutrients and wealth (metabolic substances) pass within the human body. "Jing" refers to meridians and "Luo" refers to collateral veins, with meridians being vertical veins and collateral veins being horizontal veins. There are twelve regular meridians and eight extraordinary meridians. The regular meridians are classified by yin and yang, with yin being divided into the three yin categories of Taiyin, Shaoyin and Jueyin, and yang being divided into the three yang categories of Taiyang, Yangming and Shaoyang. The hands and feet are each assigned a meridian that belongs to one of the three yangs and three yin, making a total of twelve meridians.
非特許文献２には、臨床において検査法および評価法の目的で用いた経絡テストの有用性が記載されている。この非特許文献２には、経絡テストによって全身から自覚していない不調を検出し、治療後の身体変化を自覚していない患者に対して経絡テスト陽性数を用いてその変化を示すことができたことが記載されている。 Non-Patent Document 2 describes the usefulness of the meridian test when used in clinical practice for the purposes of testing and evaluation. This non-patent document 2 describes how the meridian test can detect unconscious disorders from the whole body, and how the number of positive meridian tests can be used to show changes in the body of patients who are unaware of such changes after treatment.
非特許文献３には、内科疾患に対する鍼灸経絡治療の有用性が記載されている。この非特許文献３には、ある臓器が不調になるとその関連する経絡の気血の流れが悪くなるため、経絡に対応する体表の経穴を針や灸を用いて刺激することにより、気血の流れを調整することで体の歪みを治し臓腑の調子を整えることができる旨が記載されている。 Non-Patent Document 3 describes the usefulness of acupuncture and moxibustion meridian treatment for internal diseases. This non-patent document 3 describes that when an organ is out of order, the flow of qi and blood in the associated meridian becomes poor, so by stimulating the acupuncture points on the body surface that correspond to the meridian with needles and moxibustion, the flow of qi and blood can be adjusted, correcting distortions in the body and adjusting the condition of the internal organs.
しかしながら、経絡に対する刺激を利用する漢方薬の疾患に対する有効性の判定方法は、開示されてはいない。 However, no method has been disclosed for determining the effectiveness of herbal medicines that utilize stimulation of the meridians against illnesses.
本発明は、経絡に対する刺激を利用して漢方薬の疾患に対する有効性の判定方法を提供することを目的とする。 The present invention aims to provide a method for determining the effectiveness of herbal medicines for treating diseases by stimulating the meridians.
本発明にかかる漢方薬の疾患に対する有効性判定方法は、前記漢方薬を使用する前における前記疾患に罹患している被験者の身体の状態である第１状態において、前記被験者の経絡に対応する体表面に温熱刺激を当て、前記温熱刺激が前記被験者の体表面のうち経絡に対応した位置に当てられてから、前記被験者が前記温熱刺激を感じるまでの第１時間を測定し、次に、漢方薬を使用した後における前記被験者の身体の状態である第２状態において、前記体表面と同じ体表面に温熱刺激を当て、前記温熱刺激が前記体表面に当てられてから、前記被験者が前記温熱刺激を感じるまでの第２時間を測定し、前記第１時間及び前記第２時間の測定を１２個の経絡において行い、少なくとも一つの経絡において、前記第１時間が８秒未満又は１２秒より大きく、且つ、前記第２時間が８秒以上１２秒以下の場合がある場合、前記漢方薬は前記疾患に対して有効であると判定する、ことを特徴とする。 The method for determining the effectiveness of a herbal medicine for a disease according to the present invention is characterized in that, in a first state, which is the physical state of a subject suffering from the disease before using the herbal medicine, a thermal stimulus is applied to a body surface corresponding to a meridian of the subject, and a first time is measured from when the thermal stimulus is applied to a position on the body surface of the subject corresponding to the meridian to when the subject feels the thermal stimulus; next, in a second state, which is the physical state of the subject after using the herbal medicine, a thermal stimulus is applied to the same body surface as the first body surface, and a second time is measured from when the thermal stimulus is applied to the body surface to when the subject feels the thermal stimulus; the first and second times are measured for 12 meridians; and, if the first time is less than 8 seconds or greater than 12 seconds and the second time is between 8 seconds and 12 seconds for at least one meridian, the herbal medicine is determined to be effective for the disease.
本発明によれば、簡易な手法により、漢方薬の疾患に対する有効性を判定できる。 According to the present invention, the effectiveness of a herbal medicine for a disease can be determined using a simple method.
以下、添付の図面を参照して本発明の実施形態について具体的に説明するが、当該実施形態は本発明の原理の理解を容易にするためのものであり、本発明の範囲は、下記の実施形態に限られるものではなく、当業者が以下の実施形態の構成を適宜置換した他の実施形態も、本発明の範囲に含まれる。 The following describes in detail an embodiment of the present invention with reference to the attached drawings. However, this embodiment is intended to facilitate understanding of the principles of the present invention, and the scope of the present invention is not limited to the embodiment described below. Other embodiments in which a person skilled in the art appropriately replaces the configuration of the embodiment described below are also included in the scope of the present invention.
本発明にかかる試験対象である漢方薬の疾患に対する有効性判定方法は、まず、漢方薬を使用する前における疾患に罹患している被験者の身体の状態である第１状態において、被験者の経絡に対応する体表面に温熱刺激を当て、温熱刺激が被験者の体表面のうち経絡に対応した位置に当てられてから、被験者が温熱刺激を感じるまでの第１時間を測定する。 The method for determining the effectiveness of a herbal medicine against a disease that is the subject of the present invention involves first applying a thermal stimulus to a body surface corresponding to a meridian of a subject suffering from a disease in a first state, which is the physical state of the subject before the use of the herbal medicine, and measuring the first time from when the thermal stimulus is applied to a position on the subject's body surface that corresponds to the meridian until the subject feels the thermal stimulus.
次に、漢方薬を使用した後における被験者の身体の状態である第２状態において、体表面と同じ体表面に温熱刺激を当て、温熱刺激が体表面に当てられてから、被験者が温熱刺激を感じるまでの第２時間を測定する。 Next, in a second state, which is the subject's physical state after using the herbal medicine, a thermal stimulus is applied to the same body surface as the body surface, and a second time is measured from when the thermal stimulus is applied to the body surface until the subject feels the thermal stimulus.
これらの手順を１２個の経絡において行い、それぞれにおいて第１時間及び第２時間の測定をする。 These procedures are performed on 12 meridians, taking first and second time measurements for each.
その結果、少なくとも一つの経絡において、第１時間が８秒未満又は１２秒より大きい異常時間であり、且つ、第２時間が８秒以上１２秒以下の正常時間の場合、試験対象の漢方薬は疾患に対して有効であると判定する。 As a result, if the first time is abnormal, being less than 8 seconds or greater than 12 seconds, and the second time is normal, being between 8 and 12 seconds, for at least one meridian, the herbal medicine being tested is determined to be effective against the disease.
被験者の経絡に対応する体表面に温熱刺激を当て、温熱刺激が被験者の体表面のうち経絡に対応した位置に当てられてから、被験者が温熱刺激を感じるまでの時間の測定については、図１に示される経絡温熱刺激診断装置５０を用いることができる。経絡温熱刺激診断装置５０は、温熱刺激具１と、活動電位測定部２と、電源をオンオフするスイッチ３と、SDカード挿入口４と、情報を表示する画面５と、身体判定部６と、装置を冷却するための冷却ファン７と、時間測定部８と、本体１０と、を有する。活動電位測定部２は、活動電位計算部２１と、シグナル拡大部２２と、貼付用測定切片２３と、を有する。 The meridian thermal stimulation diagnostic device 50 shown in FIG. 1 can be used to apply a thermal stimulus to the body surface of the subject that corresponds to the meridian and measure the time from when the thermal stimulus is applied to the position on the body surface of the subject that corresponds to the meridian until the subject feels the thermal stimulus. The meridian thermal stimulation diagnostic device 50 has a thermal stimulation device 1, an action potential measurement unit 2, a switch 3 for turning the power on and off, an SD card insertion port 4, a screen 5 for displaying information, a body judgment unit 6, a cooling fan 7 for cooling the device, a time measurement unit 8, and a main body 10. The action potential measurement unit 2 has an action potential calculation unit 21, a signal magnification unit 22, and a measurement strip for application 23.
温熱刺激具１は、経絡に対応する被験者の体表面に当てられて被験者に温熱刺激を与える。温熱刺激具１は棒状構造であり、その先端部に例えばヒーターが設けられており、その先端部は例えば５０℃～８０℃にて発熱可能である。 The thermal stimulation device 1 is placed on the body surface of the subject corresponding to the meridians to provide thermal stimulation to the subject. The thermal stimulation device 1 has a rod-shaped structure, and a heater, for example, is provided at the tip of the rod, and the tip can generate heat at, for example, 50°C to 80°C.
時間測定部８は、例えばタイマーであり、温熱刺激具１が被験者の体表面のうち経絡に対応した位置に当てられてから、被験者が温熱刺激具の温熱刺激を感じるまでの時間を測定する。例えば温熱刺激具１が被験者の体表面に当てられた時に時間の測定を開始し、次に被験者が温熱刺激を感じる旨の発言があった時に時間の測定を停止することで、温熱刺激具１が被験者に当てられてから、被験者が温熱刺激具の温熱刺激を感じるまでの時間を測定できる。 The time measurement unit 8 is, for example, a timer, and measures the time from when the thermal stimulation device 1 is applied to a position on the subject's body surface that corresponds to a meridian until the subject feels the thermal stimulation of the thermal stimulation device. For example, by starting time measurement when the thermal stimulation device 1 is applied to the subject's body surface and stopping time measurement the next time the subject says that they feel a thermal stimulation, it is possible to measure the time from when the thermal stimulation device 1 is applied to the subject until the subject feels the thermal stimulation of the thermal stimulation device.
なお、被験者が幼児や高齢者等の場合は、温熱刺激具１の温熱刺激を感じる旨の発言を適切に行うことができない虞もある。その場合は神経細胞や筋細胞の膜が温熱刺激に応じて活動電位を発生することを利用して、活動電位測定部２により被験者が温熱刺激を感じたか否かを判断することができる。例えば貼付用測定切片２３を被験者の腕部や脚部に貼り付け、温熱刺激に対応して発生した活動電位をシグナル拡大部２２により増幅し、活動電位計算部２１により被験者の活動電位を計算する。 If the subject is an infant or elderly person, there is a risk that they may not be able to properly state that they feel the thermal stimulation from the thermal stimulation device 1. In such a case, the action potential measuring unit 2 can determine whether the subject has felt the thermal stimulation by utilizing the fact that the membranes of nerve cells and muscle cells generate action potentials in response to thermal stimulation. For example, the adhesive measuring strip 23 is attached to the subject's arm or leg, the action potential generated in response to the thermal stimulation is amplified by the signal amplification unit 22, and the action potential of the subject is calculated by the action potential calculation unit 21.
身体判定部６は、時間測定部８により測定された時間が８秒以上１２秒以下の場合(正常時間の場合)、被験者は正常であると判定する。しかし、時間測定部８により測定された時間が８秒より少ない場合又は１２秒よりも多い場合(異常時間の場合)、被験者に疾患の存在の可能性を判定する。 The physical assessment unit 6 determines that the subject is normal if the time measured by the time measurement unit 8 is between 8 and 12 seconds (normal time). However, if the time measured by the time measurement unit 8 is less than 8 seconds or more than 12 seconds (abnormal time), it determines that the subject may have a disease.
経絡は、太陰肺経、陽明大腸経、陽明胃経、太陰脾経、少陰心経、太陽小腸経、太陽膀胱経、少陰腎経、厥陰心包経、少陽三焦経、少陽胆経、及び、厥陰肝経からなる１２個の経絡である（図２）。 There are 12 meridians: the Taiyin Lung meridian, the Yangming Large Intestine meridian, the Yangming Stomach meridian, the Taiyin Spleen meridian, the Shaoyin Heart meridian, the Taiyang Small Intestine meridian, the Taiyang Bladder meridian, the Shaoyin Kidney meridian, the Jueyin Pericardium meridian, the Shaoyang Triple Burner meridian, the Shaoyang Gallbladder meridian, and the Jueyin Liver meridian (Figure 2).
図２に示されるように、体の片側には１２本ずつの経絡があり、それぞれ左右対称になっている。各経絡に沿って、ツボ(経穴)と呼ばれる特定のポイントがあり、気はそのポイントから体の表面へ流れている。下記にある経絡における左側と右側の判定が異なる場合を含めて説明をする。 As shown in Figure 2, there are 12 meridians on each side of the body, each side being symmetrical. Along each meridian there are specific points called acupoints (acupuncture points) from which Qi flows to the surface of the body. Below we explain the cases where the interpretation of the left and right sides of the meridians differs.
ある経絡の左側での測定において第１時間が異常時間であり、その経絡の右側での測定において第１時間が異常時間であるが、その経絡の左側での測定において第２時間が正常時間であり、その経絡の右側での測定において第２時間が正常時間である場合、試験対象の漢方薬は疾患に対して有効である。 If the first time is abnormal when measured on the left side of a meridian and the first time is abnormal when measured on the right side of the meridian, but the second time is normal when measured on the left side of the meridian and the second time is normal when measured on the right side of the meridian, then the herbal medicine being tested is effective against the disease.
ある経絡の左側での測定において第１時間が異常時間であり、その経絡の右側での測定において第１時間が正常時間であるが、その経絡の左側での測定において第２時間が正常時間であり、その経絡の右側での測定において第２時間が正常時間である場合、試験対象の漢方薬は疾患に対して有効である。 If the first time is abnormal when measured on the left side of a meridian and the first time is normal when measured on the right side of the meridian, but the second time is normal when measured on the left side of the meridian and the second time is normal when measured on the right side of the meridian, then the herbal medicine being tested is effective against the disease.
ある経絡の左側での測定において第１時間が正常時間であり、その経絡の右側での測定において第１時間が異常時間であるが、その経絡の左側での測定において第２時間が正常時間であり、その経絡の右側での測定において第２時間が正常時間である場合、試験対象の漢方薬は疾患に対して有効である。 If the first time is normal when measured on the left side of a meridian and the first time is abnormal when measured on the right side of the meridian, but the second time is normal when measured on the left side of the meridian and the second time is normal when measured on the right side of the meridian, then the herbal medicine being tested is effective against the disease.
ある経絡の左側での測定において第１時間が異常時間であり、その経絡の右側での測定において第１時間が異常時間であるが、その経絡の左側での測定において第２時間が異常時間であり、その経絡の右側での測定において第２時間が異常時間である場合、試験対象の漢方薬は疾患に対して有効ではない。 If the first time is abnormal when measured on the left side of a meridian and the first time is abnormal when measured on the right side of the meridian, but the second time is abnormal when measured on the left side of the meridian and the second time is abnormal when measured on the right side of the meridian, then the herbal medicine being tested is not effective against the disease.
ある経絡の左側での測定において第１時間が異常時間であり、その経絡の右側での測定において第１時間が異常時間であるが、その経絡の左側での測定において第２時間が異常時間であり、その経絡の右側での測定において第２時間が正常時間である場合、試験対象の漢方薬は疾患に対して有効ではないと判定することができる。左右ともに正常時間ではないため有効性に疑問が残るからである。 If the first time is abnormal when measured on the left side of a certain meridian and the first time is abnormal when measured on the right side of the meridian, but the second time is abnormal when measured on the left side of the meridian and the second time is normal when measured on the right side of the meridian, it can be determined that the herbal medicine being tested is not effective against the disease. This is because the effectiveness remains questionable as both the left and right times are not normal.
ある経絡の左側での測定において第１時間が異常時間であり、その経絡の右側での測定において第１時間が異常時間であるが、その経絡の左側での測定において第２時間が正常時間であり、その経絡の右側での測定において第２時間が異常時間である場合、試験対象の漢方薬は疾患に対して有効ではないと判定することができる。左右ともに正常時間ではないため有効性に疑問が残るからである。 If the first time is abnormal when measured on the left side of a certain meridian and the first time is abnormal when measured on the right side of the meridian, but the second time is normal when measured on the left side of the meridian and the second time is abnormal when measured on the right side of the meridian, then it can be determined that the herbal medicine being tested is not effective against the disease. This is because the effectiveness is questionable as both the left and right times are not normal.
上記の結果を下記表１に示す。ここで○は正常時間を示し×は異常時間を示す。 The above results are shown in Table 1 below. Here, ○ indicates normal time and × indicates abnormal time.
次に、経絡は１２個あるが、そのうちある経絡においては試験対象の漢方薬は有効であると判定されるが、その経絡と異なる経絡においては試験対象の漢方薬は無効であると判定される場合、有効であると判定される経絡の数が無効であると判定される経絡の数よりも多い場合のみ、試験対象の漢方薬は疾患に対して有効であると判定する。 Next, there are 12 meridians, and in some of these, the herbal medicine being tested is judged to be effective, but in other meridians, the herbal medicine being tested is judged to be ineffective. In that case, the herbal medicine being tested is judged to be effective against the disease only if the number of meridians judged to be effective is greater than the number of meridians judged to be ineffective.
本発明の経絡温熱刺激診断装置５０では、温熱刺激具１を１２個全ての経絡に対応する被験者の体表面に当てて検査を行う。例えば図３に示す被験者の体表面に温熱刺激具１を当てて検査を行うことが可能である。 In the meridian thermal stimulation diagnostic device 50 of the present invention, the thermal stimulation device 1 is applied to the body surface of the subject corresponding to all 12 meridians to perform the examination. For example, it is possible to perform the examination by applying the thermal stimulation device 1 to the body surface of the subject shown in Figure 3.
十二経脈の流れには一定の順序があり、図４に示されるように、手太陰肺経から始まり、順に従って足厥陰肝経に至り、再び太陰肺経にもどる。もっとも検査を行う１２個の経絡の順番は、特に限定されるものではない。手太陰肺経は肺に属し、大腸に絡し、手陽明大腸経は大腸に属し、肺に絡す。手厥陰心包経は心包に属し、三焦に絡し、手少陽三焦経は三焦に属し、心包に絡す。手少陰心経は心に属し、小腸に絡し、手太陽小腸経は小腸に属し、心に絡す。足太陰脾経は脾に属し、胃に絡し、足陽明胃経は胃に属し、脾に絡す。足厥陰肝経は肝に属し、胆に絡し、足少陽胆経は胆に属し、肝に絡す。足少陰腎経は腎に属し、膀胱に絡し、足太陽膀胱経は膀胱に属し、腎に絡す。即ち、肺経と大腸経、心包経と三焦経、心経と小腸経、脾経と胃経、肝経と胆経、腎経と膀胱経が、それぞれ相互に表裏を為している。 The twelve meridians flow in a certain order, starting from the hand Taiyin Lung meridian, as shown in Figure 4, and proceeding in sequence to the Foot Jueyin Liver meridian and back to the Taiyin Lung meridian. However, the order in which the twelve meridians are examined is not particularly limited. The hand Taiyin Lung meridian belongs to the lungs and connects to the large intestine, the hand Yangming Large Intestine meridian belongs to the large intestine and connects to the lungs. The hand Jueyin Pericardium meridian belongs to the pericardium and connects to the triple burner, the hand Shaoyang Triple Burner meridian belongs to the triple burner and connects to the pericardium. The hand Shaoyin Heart meridian belongs to the heart and connects to the small intestine, the hand Taiyin Small Intestine meridian belongs to the small intestine and connects to the heart. The foot Taiyin Spleen meridian belongs to the spleen and connects to the stomach, and the foot Yangming Stomach meridian belongs to the stomach and connects to the spleen. The foot Jueyin Liver meridian belongs to the liver and connects to the gallbladder, and the foot Shaoyang Gallbladder meridian belongs to the gallbladder and connects to the liver. The foot Shaoyin Kidney Meridian belongs to the kidneys and connects to the bladder, and the foot Taiyang Bladder Meridian belongs to the bladder and connects to the kidneys. In other words, the Lung Meridian and Large Intestine Meridian, the Pericardium Meridian and Triple Burner Meridian, the Heart Meridian and Small Intestine Meridian, the Spleen Meridian and Stomach Meridian, the Liver Meridian and Gallbladder Meridian, and the Kidney Meridian and Bladder Meridian are each mutually opposite to each other.
太陰肺経において、中府、云門、天府、侠白、少商等から選択して温熱刺激具１を当てることが可能で有り、好ましくは少商である。 In the Taiyin Lung Meridian, it is possible to apply the thermal stimulation device 1 to a selected point from Zhongfu, Yunmen, Tianfu, Xia Bai, Shao Shang, etc., with Shao Shang being preferred.
陽明大腸経において、商陽、二間、三間、合谷、陽谿等から選択して温熱刺激具１を当てることが可能で有り、好ましくは商陽である。 In the Yangming large intestine meridian, it is possible to apply the thermal stimulation device 1 to a selected point from Shang Yang, Er Jian, San Jian, He Gu, Yang Xi, etc., and preferably to Shang Yang.
陽明胃経において、解渓、衝陽、陥谷、内庭、レイダ等から選択して温熱刺激具１を当てることが可能で有り、好ましくはレイダである。 In the Yangming stomach meridian, it is possible to apply the thermal stimulation device 1 to a selected point from among Xiexi, Chongyang, Xiangu, Neiting, and Leida, with Leida being preferred.
太陰脾経において、隠白、大都、太白、公孫、商丘等から選択して温熱刺激具１を当てることが可能で有り、好ましくは隠白である。 The thermal stimulation device 1 can be applied to the Taiyin Spleen Meridian by selecting from Yinbai, Dadu, Taibai, Gongsun, Shangqiu, etc., with Yinbai being preferred.
少陰心経において、青霊、少海、霊道、通里、陰ゲキ等から選択して温熱刺激具１を当てることが可能で有り、好ましくは陰ゲキである。 In the Shaoyin Heart Sutra, it is possible to apply the thermal stimulation device 1 to a point selected from Qingling, Shaohai, Lingdao, Tongli, Yingeki, etc., with Yingeki being preferred.
太陽小腸経において少沢、前谷、後渓、腕骨、陽谷等から選択して温熱刺激具１を当てることが可能で有り、好ましくは少沢である。 The thermal stimulation device 1 can be applied to the Taiyang Small Intestine Meridian by selecting from Shaoze, Zhenggu, Hoxi, Hunchback, Yanggu, etc., with Shaoze being the preferred location.
太陽膀胱経において金門、京骨、束骨、足通谷、至陰等から選択して温熱刺激具１を当てることが可能で有り、好ましくは至陰である。 The thermal stimulation device 1 can be applied to the Taiyang Bladder Meridian by selecting from the Kinmen, Jinggu, Bungu, Zhonggu, Zhiyin, etc., with Zhiyin being preferred.
少陰腎経において湧泉、然谷、太渓、大鐘、水泉等から選択して温熱刺激具１を当てることが可能で有り、好ましくは湧泉である。 The thermal stimulation device 1 can be applied to the Shaoyin Kidney Meridian by selecting from Yongquan, Rangu, Taixi, Dazhong, Shuiquan, etc., with Yongquan being preferred.
厥陰心包経において間使、内関、大陵、労宮、中衝等から選択して温熱刺激具１を当てることが可能で有り、好ましくは中衝である。 The thermal stimulation device 1 can be applied to the Jueyin Pericardium Meridian by selecting from Ganshi, Neiguan, Daling, Laogong, Zhongchong, etc., with Zhongchong being preferred.
少陽三焦経において関衝、液門、中渚、陽池、外関等から選択して温熱刺激具１を当てることが可能で有り、好ましくは関衝である。 The thermal stimulation device 1 can be applied to the Shaoyang triple-burner meridian by selecting from Guanchong, Limen, Zhongzhu, Yangchi, Waiguan, etc., with Guanchong being preferred.
少陽胆経において丘墟、足臨泣、地五会、キョウ渓、足キョウ陰等から選択して温熱刺激具１を当てることが可能で有り、好ましくは足キョウ陰である。 The thermal stimulation device 1 can be applied to the Shaoyang Gallbladder meridian by selecting from Qiu Xu, Zolinqi, Diwuhui, Kyoxi, Zojiyin, etc., with Zojiyin being preferred.
厥陰肝経において大敦、行間、太衝、中封、レイ溝等から選択して温熱刺激具１を当てることが可能で有り、好ましくは大敦である。 The thermal stimulation device 1 can be applied to the Jueyin Liver meridian by selecting from Dadu, Xingjian, Taichong, Zhongfeng, Leigou, etc., with Dadu being preferred.
1.実施例1
被験者X1(女性、40歳)は、悪寒、子宮の冷え、むくみを訴えた。被験者X1は主として冷え症の症状と思われた。被験者X1に対して、温熱刺激具１を１２個全ての経絡(太陰肺経、陽明大腸経、厥陰心包経、少陽三焦経、少陰心経、太陽小腸経、太陰脾経、厥陰肝経、陽明胃経、少陽胆経、太陽膀胱経、及び、少陰腎経)に対応する被験者の左右それぞれの体表面に当てて検査を行った。表２に示すように、太陰肺経及び太陽膀胱経等に１２秒より多い異常時間が認められた。被験者X1に桂枝茯苓丸(ツムラ漢方桂枝茯苓丸料エキス顆粒A)を処方した。桂枝茯苓丸は、月経不順、月経異常、月経痛、更年期障害、血の道症注）、肩こり、めまい、頭重、打ち身（打撲症）、しもやけ、しみ、湿疹・皮膚炎、にきび等に効用があるとされる。被験者X1が桂枝茯苓丸を服用後に測定したところ、太陰肺経及び太陽膀胱経ともに正常時間になった。これにより桂枝茯苓丸は冷え症の症状にも有効であることが示唆された。
1. Example 1
Subject X1 (female, 40 years old) complained of chills, coldness of uterus, and swelling. Subject X1's symptoms were thought to be mainly cold sensitivity. Subject X1 was examined by placing the heat stimulation device 1 on the left and right body surfaces of the subject corresponding to all 12 meridians (Tain Lung Meridian, Yangming Large Intestine Meridian, Jueyin Pericardium Meridian, Shaoyang Triple Burner Meridian, Shaoyin Heart Meridian, Taiyang Small Intestine Meridian, Taiyin Spleen Meridian, Jueyin Liver Meridian, Yangming Stomach Meridian, Shaoyang Gallbladder Meridian, Taiyang Bladder Meridian, and Shaoyin Kidney Meridian). As shown in Table 2, abnormal times of more than 12 seconds were observed in the Taiyin Lung Meridian and Taiyang Bladder Meridian. Subject X1 was prescribed Keishibukuryo-gan (Tsumura Kampo Keishibukuryo-gan Extract Granules A). Keishibukuryo-gan is said to be effective for menstrual irregularities, menstrual abnormalities, menstrual pain, menopausal disorders, blood disorders (note), stiff shoulders, dizziness, heavy head, bruises (contusions), chilblains, age spots, eczema/dermatitis, acne, etc. When subject X1 was measured after taking Keishibukuryo-gan, both the Taiyin Lung Meridian and the Taiyang Bladder Meridian returned to normal. This suggests that Keishibukuryo-gan is also effective for symptoms of poor circulation.
2.実施例2
被験者X2(女性、29歳)は、悪寒、膀胱の冷え、月経不調、乳腺増大を訴えた。被験者X2は主として乳腺症の症状と思われた。被験者X2に対して、温熱刺激具１を１２個全ての経絡(太陰肺経、陽明大腸経、厥陰心包経、少陽三焦経、少陰心経、太陽小腸経、太陰脾経、厥陰肝経、陽明胃経、少陽胆経、太陽膀胱経、及び、少陰腎経)に対応する被験者の左右それぞれの体表面に当てて検査を行った。表３に示すように、陽明大腸経及び及び太陽膀胱経等に１２秒より多い異常時間が認められた。被験者X2に当帰芍薬散(ツムラ漢方当帰芍薬散料エキス顆粒)を処方した。当帰芍薬散は、月経不順、月経異常、月経痛、更年期障害、産前産後あるいは流産による障害（貧血、疲労倦怠、めまい、むくみ）、めまい・立ちくらみ、頭重、肩こり、腰痛、足腰の冷え症、しもやけ、むくみ、しみ、耳鳴り等に効用があるとされる。被験者X2が当帰芍薬散を服用後に測定したところ、陽明大腸経では異常時間のままであった。太陽膀胱経では左側では正常時間であったが右側では異常時間のままであった。これにより当帰芍薬散は乳腺炎の症状には有効ではないことが示唆された。
2. Example 2
Subject X2 (female, 29 years old) complained of chills, cold bladder, menstrual irregularity, and mammary gland enlargement. Subject X2's symptoms were thought to be mainly mastopathy. Subject X2 was examined by applying the heat stimulation device 1 to the left and right body surfaces of the subject corresponding to all 12 meridians (Taiyin Lung Meridian, Yangming Large Intestine Meridian, Jueyin Pericardium Meridian, Shaoyang Triple Burner Meridian, Shaoyin Heart Meridian, Taiyang Small Intestine Meridian, Taiyin Spleen Meridian, Jueyin Liver Meridian, Yangming Stomach Meridian, Shaoyang Gallbladder Meridian, Taiyang Bladder Meridian, and Shaoyin Kidney Meridian). As shown in Table 3, abnormal times of more than 12 seconds were observed in the Yangming Large Intestine Meridian and the Taiyang Bladder Meridian. Subject X2 was prescribed Touki-shakuyakusan (Tsumura Kampo Touki-shakuyakusan Extract Granules). Toki-shakuyakusan is said to be effective for menstrual irregularities, menstrual abnormalities, menstrual pain, menopausal disorders, disorders before and after childbirth or due to miscarriage (anemia, fatigue, dizziness, swelling), dizziness, lightheadedness, stiff shoulders, lower back pain, cold feet and legs, chilblains, swelling, age spots, tinnitus, etc. When subject X2 was measured after taking Toki-shakuyakusan, the time on the Yangming large intestine meridian remained abnormal. The time on the Taiyang bladder meridian was normal on the left side, but remained abnormal on the right side. This suggests that Toki-shakuyakusan is not effective for symptoms of mastitis.
3.実施例3
被験者X3(男性、66歳)は、悪寒、脾臓の冷え、頻繁な痰を訴えた。被験者X3は主として脾膿瘍の症状と思われた。被験者X3に対して、温熱刺激具１を１２個全ての経絡(太陰肺経、陽明大腸経、厥陰心包経、少陽三焦経、少陰心経、太陽小腸経、太陰脾経、厥陰肝経、陽明胃経、少陽胆経、太陽膀胱経、及び、少陰腎経)に対応する被験者の左右それぞれの体表面に当てて検査を行った。表４に示すように、太陰肺経及び陽明大腸経等に８秒より少ない異常時間が認められた。被験者X3に柴胡加竜骨牡蛎湯(ツムラ柴胡加竜骨牡蛎湯)を処方した。柴胡加竜骨牡蛎湯は、神経症、子どもの夜泣き、高血圧に伴う不眠、神経性の心悸亢進の改善等に効用があるとされる。被験者X3が柴胡加竜骨牡蛎湯を服用後に測定したところ、太陰肺経及び陽明大腸経ともに正常時間になった。これにより柴胡加竜骨牡蛎湯は脾膿瘍の症状にも有効であることが示唆された。
3. Example 3
Subject X3 (male, 66 years old) complained of chills, cold spleen, and frequent phlegm. Subject X3's symptoms were thought to be mainly splenic abscess. Subject X3 was examined by applying the heat stimulation device 1 to the left and right body surfaces of the subject corresponding to all 12 meridians (Taiyin Lung Meridian, Yangming Large Intestine Meridian, Jueyin Pericardium Meridian, Shaoyang Triple Burner Meridian, Shaoyin Heart Meridian, Taiyang Small Intestine Meridian, Taiyin Spleen Meridian, Jueyin Liver Meridian, Yangming Stomach Meridian, Shaoyang Gallbladder Meridian, Taiyang Bladder Meridian, and Shaoyin Kidney Meridian). As shown in Table 4, abnormal times of less than 8 seconds were observed in the Taiyin Lung Meridian and Yangming Large Intestine Meridian. Subject X3 was prescribed Saikokaryukotsuboreito (Tsumura Saikokaryukotsuboreito). Saikokaryukotsuboreito is said to be effective in improving neurosis, children's night crying, insomnia due to high blood pressure, and nervous palpitations. When subject X3 was measured after taking Saikokaryukotsuboreito, both the Taiyin Lung Meridian and Yangming Large Intestine Meridian returned to normal. This suggests that Saikokaryukotsuboreito is also effective for the symptoms of splenic abscess.
4.実施例4
被験者X4(女性、44歳)は、上熱下寒、崩漏(子宮の内部がただれて出血する病気)を訴えた。被験者X4は主として崩漏の症状と思われた。被験者X4に対して、温熱刺激具１を１２個全ての経絡(太陰肺経、陽明大腸経、厥陰心包経、少陽三焦経、少陰心経、太陽小腸経、太陰脾経、厥陰肝経、陽明胃経、少陽胆経、太陽膀胱経、及び、少陰腎経)に対応する被験者の左右それぞれの体表面に当てて検査を行った。表５に示すように、太陽膀胱経及び少陰腎経等に１２秒より多い異常時間が認められた。被験者X4に補中益気湯(ツムラ補中益気湯)を処方した。補中益気湯は、胃腸虚弱、かぜ、寝汗、食欲不振等に効用があるとされる。被験者X4が補中益気湯を服用後に測定したところ、太陽膀胱経では異常時間のままであった。少陰腎経では左側では正常時間であったが右側では異常時間のままであった。これにより補中益気湯は崩漏の症状には有効ではないことが示唆された。
4. Example 4
Subject X4 (female, 44 years old) complained of upper fever, lower chill, and leaking uterus (a disease in which the inside of the uterus becomes eroded and bleeds). Subject X4's symptoms were mainly thought to be leaking uterus. Subject X4 was examined by applying the heat stimulation device 1 to the left and right body surfaces of the subject corresponding to all 12 meridians (Taiyin Lung Meridian, Yangming Large Intestine Meridian, Jueyin Pericardium Meridian, Shaoyang Triple Burner Meridian, Shaoyin Heart Meridian, Taiyang Small Intestine Meridian, Taiyin Spleen Meridian, Jueyin Liver Meridian, Yangming Stomach Meridian, Shaoyang Gallbladder Meridian, Taiyang Bladder Meridian, and Shaoyin Kidney Meridian). As shown in Table 5, abnormal times of more than 12 seconds were observed in the Taiyang Bladder Meridian and Shaoyin Kidney Meridian. Subject X4 was prescribed Hochu-ekki-to (Tsumura Hochu-ekki-to). Hochu-ekki-to is said to be effective for gastrointestinal weakness, colds, night sweats, loss of appetite, etc. When subject X4 was measured after taking Hochuekkito, the Taiyang Bladder Meridian remained abnormal. The Shaoyin Kidney Meridian remained normal on the left side, but remained abnormal on the right side. This suggests that Hochuekkito is not effective for the symptoms of uterine leakage.
5.実施例5
被験者X5(女性、51歳)は、上熱下寒、膀胱の冷え、失眠、腰筋過労を訴えた。被験者X5は主として膀胱炎の症状と思われた。被験者X5に対して、温熱刺激具１を１２個全ての経絡(太陰肺経、陽明大腸経、厥陰心包経、少陽三焦経、少陰心経、太陽小腸経、太陰脾経、厥陰肝経、陽明胃経、少陽胆経、太陽膀胱経、及び、少陰腎経)に対応する被験者の左右それぞれの体表面に当てて検査を行った。表６に示すように、太陽膀胱経にその左側に１２秒より多い異常時間が認められた。被験者X5に八味地黄丸(ツムラ八味地黄丸)を処方した。八味地黄丸は、頻尿・夜間頻尿、排尿困難、残尿感、軽い尿漏れ、腰痛、しびれ、かすみ目など、老化にともなう症状等に効用があるとされる。被験者X5が八味地黄丸を服用後に測定したところ、太陽膀胱経の左側では異常時間のままであり、右側では異常時間となった。これにより八味地黄丸は膀胱炎の症状には有効ではないことが示唆された。
5. Example 5
Subject X5 (female, 51 years old) complained of upper heat and lower cold, cold bladder, insomnia, and psoas muscle fatigue. Subject X5's symptoms were thought to be mainly cystitis. Subject X5 was examined by applying the heat stimulation device 1 to the left and right body surfaces of the subject corresponding to all 12 meridians (Taiyin Lung Meridian, Yangming Large Intestine Meridian, Jueyin Pericardium Meridian, Shaoyang Triple Burner Meridian, Shaoyin Heart Meridian, Taiyang Small Intestine Meridian, Taiyin Spleen Meridian, Jueyin Liver Meridian, Yangming Stomach Meridian, Shaoyang Gallbladder Meridian, Taiyang Bladder Meridian, and Shaoyin Kidney Meridian). As shown in Table 6, an abnormal time of more than 12 seconds was observed on the left side of the Taiyang Bladder Meridian. Subject X5 was prescribed Hachimijiogan (Tsumura Hachimijiogan). Hachimijiogan is said to be effective for symptoms associated with aging, such as frequent urination, nocturnal urination, difficulty in urination, residual urine, slight urinary leakage, lower back pain, numbness, and blurred vision. When subject X5 was measured after taking Hachimijiogan, the left side of the Taiyang Bladder Meridian remained abnormal, while the right side became abnormal, suggesting that Hachimijiogan was not effective for the symptoms of cystitis.
漢方薬の疾患に対する有効性の判断に利用できる。 It can be used to determine the effectiveness of herbal medicines for diseases.
１：温熱刺激具
２：活動電位測定部
３：スイッチ
４：SDカード挿入口
５：画面
６：身体判定部
７：冷却ファン
８：時間測定部
１０：本体
５０：経絡温熱刺激診断装置
1: Thermal stimulation device 2: Action potential measurement unit 3: Switch 4: SD card slot 5: Screen 6: Body judgment unit 7: Cooling fan 8: Time measurement unit 10: Main unit 50: Meridian thermal stimulation diagnostic device
Claims (9)
前記漢方薬を使用する前における前記疾患に罹患している被験者の身体の状態である第１状態において、
前記被験者の経絡に対応する体表面に温熱刺激を当て、前記温熱刺激が前記被験者の体表面のうち経絡に対応した位置に当てられてから、前記被験者が前記温熱刺激を感じるまでの第１時間を測定し、
次に、漢方薬を使用した後における前記被験者の身体の状態である第２状態において、
前記体表面と同じ体表面に温熱刺激を当て、前記温熱刺激が前記体表面に当てられてから、前記被験者が前記温熱刺激を感じるまでの第２時間を測定し、
前記第１時間及び前記第２時間の測定を１２個の経絡において行い、
少なくとも一つの経絡において、前記第１時間が８秒未満又は１２秒より大きい異常時間であり、且つ、前記第２時間が８秒以上１２秒以下の正常時間である場合、前記漢方薬は前記疾患に対して有効であると判定する、ことを特徴とする漢方薬の疾患に対する有効性判定方法。 A method for determining the effectiveness of a herbal medicine for a disease, comprising:
In a first state, which is a physical state of a subject suffering from the disease before using the herbal medicine,
applying a thermal stimulus to a body surface of the subject corresponding to the meridian, and measuring a first time from when the thermal stimulus is applied to a position on the body surface of the subject corresponding to the meridian to when the subject feels the thermal stimulus;
Next, in a second state, which is the physical state of the subject after using the herbal medicine,
applying a thermal stimulus to the same body surface as the body surface, and measuring a second time from when the thermal stimulus is applied to the body surface until the subject feels the thermal stimulus;
The first time and the second time are measured at 12 meridians;
A method for determining the effectiveness of a herbal medicine for a disease, characterized in that if, in at least one meridian, the first time is an abnormal time of less than 8 seconds or more than 12 seconds, and the second time is a normal time of 8 seconds or more and 12 seconds or less, the herbal medicine is determined to be effective for the disease.
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| JP2004277357A (en) | 2003-03-17 | 2004-10-07 | Tsuneo Imanaka | AGENT FOR ACTIVATING FATTY ACID-beta-OXIDATION SYSTEM OF PEROXISOME, AND METHOD FOR SCREENING MATERIAL FOR ACTIVATING FATTY ACID-beta-OXIDATION SYSTEM OF PEROXISOME |
| WO2005023280A1 (en) | 2003-09-11 | 2005-03-17 | Vital Pharmaceuticals (Sichuan) Company Limited | Oral treatment for anorectal conditions |
| JP2008511555A (en) | 2004-09-03 | 2008-04-17 | 建生 王 | Drugs with analgesic action |
| WO2017146230A1 (en) | 2016-02-24 | 2017-08-31 | 国立大学法人大阪大学 | Test method |
| JP2019136053A (en) | 2018-02-06 | 2019-08-22 | 政 田 | Meridian thermal stimulation diagnostic device |
| CN114075591A (en) | 2021-11-10 | 2022-02-22 | 夏永刚 | Evaluation and screening method for properties and components of Chinese medicinal channel-guiding herbs |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2004277357A (en) | 2003-03-17 | 2004-10-07 | Tsuneo Imanaka | AGENT FOR ACTIVATING FATTY ACID-beta-OXIDATION SYSTEM OF PEROXISOME, AND METHOD FOR SCREENING MATERIAL FOR ACTIVATING FATTY ACID-beta-OXIDATION SYSTEM OF PEROXISOME |
| WO2005023280A1 (en) | 2003-09-11 | 2005-03-17 | Vital Pharmaceuticals (Sichuan) Company Limited | Oral treatment for anorectal conditions |
| JP2008511555A (en) | 2004-09-03 | 2008-04-17 | 建生 王 | Drugs with analgesic action |
| WO2017146230A1 (en) | 2016-02-24 | 2017-08-31 | 国立大学法人大阪大学 | Test method |
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