JP7418795B2 - Device and program for selecting crude drugs - Google Patents

Description

The present invention relates to a device for selecting crude drugs to be provided to patients suffering from lifestyle-related diseases, and a program for selecting the crude drugs (and related foodstuffs, if necessary) using an information processing device.

Visceral fat obesity syndrome, which is affecting a rapidly increasing number of elderly people, can lead to arteriosclerosis, which can lead to complications such as heart disease and stroke, and the risk of developing lifestyle-related diseases such as diabetic nephropathy. It is said that 60% of the causes of death in Japan are lifestyle-related diseases. Japan's "Healthy Japan 21" (a basic policy for the comprehensive promotion of national health, formulated based on the Health Promotion Act) sets scientific targets and implements measures for lifestyle-related diseases. The aim is to promote measures and increase the investment rate of results.

As part of the country's primary and secondary prevention policy, municipalities, insurers, business owners, etc. are required to provide health checkups and insurance guidance to medical insurers based on the provisions of relevant laws, etc., to prevent diseases and maintain health of the elderly. Activities are being promoted. However, these measures only go beyond health guidance and have not achieved substantial results in preventing the onset and severity of the disease through early treatment, and the soaring medical costs have led to a situation that could lead to the collapse of the medical system in the future. There is.

In recent years, the main causes of death in developed countries are visceral diseases and multiple cancers derived from lifestyle-related diseases, and in particular, cardiovascular diseases, which are increasing due to overnutrition caused by overeating and lack of exercise, are becoming more important. This has been reconfirmed as an important issue in solving the soaring medical costs, and calls for prevention of aggravation of diseases caused by lifestyle habits and appropriate treatment effects in medical settings.

As a specific example, the risk rate increases when three or more of the following are present: accumulation of visceral fat (intra-abdominal fat), insulin resistance, glucose intolerance, arteriosclerotic riboprotein abnormality, high blood pressure, and obesity. has announced the fact that the rate is more than 30 times that of individual control for each disease state, and is requesting that doctors take action.

Therefore, for diseases such as hypertension, hypertriglyceridemia, hypocholesterolemia, hyperglycemia, and hyperuricemia, multiple drugs are often administered at the same time over a long period of time to avoid the risk of disease progression. Become.

In response to this trend, there has already been extensive research into foods that inhibit or induce drug absorption, distribution, metabolism, and excretion in the body, and foods that affect metabolism are gradually being researched. It is becoming known. However, there are not many foods that have been certified with the evidence required for treatment, and development that will lead to clinical results is awaited.

In response to these demands, in recent years, industry and academia have come together to conduct analyzes in the field of biochemistry through gene-level analyzes related to biotechnology, which are being promoted in university laboratories and advanced companies, and to develop diseases that are created by technologies supported by production technology. A medical food for human use has been developed, and a system is already in place to proceed with clinical verification.

Moreover, Patent Document 1 discloses a combination determining device that determines the combination of supplements to be provided to users and a program that determines the combination of supplements to be provided to users.

Patent Document 2 discloses an apparatus for selecting foods to be mixed or added to meals for sick patients to be provided to sick patients. Patent Document 2 discloses that the device includes a drug input means for inputting and storing at least one prescribed drug prescribed to a patient and a prescribed dose of the drug, and a drug input means for inputting and storing food. a first food list storage section for storing a drug in association with a food that is incompatible with the drug; and a first food list storage section that searches the first food list storage section based on the prescribed drug and food. However, it is described that the method is provided with a compliant food determining means for determining whether or not a food and a prescription drug are contraindicated for combination, and a result display means for displaying the determination result. .

Moreover, Patent Document 3 discloses an apparatus for selecting food to be mixed or added to a meal for sick patients to be provided to sick patients. Patent Document 3 discloses that the device includes a disease name information input means, a disease name determination means, a disease name and trace element list storage section, a trace element determination means, a trace element and suitable food list storage section, and a suitable food determination means. and a result display means.

Patent No. 3895746 Japanese Patent Application Publication No. 2012-238200 JP2017-59228A

As a measure to combat the soaring medical costs for the elderly, a plan is being formulated to allow for early discharge from hospitals, with the aim of fundamental reform of the medical system. Specifically, it is said that in parallel with home and outpatient medication treatment systems, a system for providing guidance and supply of therapeutic food should be established to prevent the disease from worsening and becoming more serious. In order to promote early hospital discharge and establish an effective local medical system, it is desirable to establish a system in which local hospitals and clinics participate and cooperate under the guidance of public medical organizations. On the other hand, due to regulations under the Pharmaceutical Affairs Law, which require that a doctor prescribe or give an order and that the products supplied are pharmaceuticals, there is a reality in which effective meals cannot be provided as therapeutic foods, and this should be legally reformed. There is a need. As long as the current situation continues, it will become a barrier to reducing medical costs. That is, since the supply of therapeutic food according to the instructions of a doctor is all regulated by the Pharmaceutical Affairs Law, it is difficult to supply functional therapeutic food to patients easily and at low cost within legal regulations.

Furthermore, among the specified health foods on the general market aimed at healthy people or those who are not sick, there are functional foods that contain indigestible dextrin. When a patient who consumes functional foods is given the cardiotonic drug digitalis or the anti-solid drug warfarin by a doctor, the ingredients of the drugs are absorbed into the dietary fiber of indigestible dextrin, reducing the drug's efficacy. It has been pointed out that there is a risk that it may interfere with disease treatment.

Additionally, when monoamine enzymes (MAO) are administered to foods that are commonly consumed, such as grapefruit juice, cytochrome P450, which is involved in intracellular oxidation and reduction, is inhibited, increasing drug absorption. . Some cautions have been issued regarding St. John's wort and asthma treatment drugs, as their effects are attenuated by CYP3A induction, and that they interact with each other, weakening or enhancing the drug's effects.

Furthermore, in recent years, when looking at the medical field, modernization is progressing rapidly due to technological advances. In addition, in order to respond to advanced medical care, a wide variety of medical staff are based on a high level of expertise, share goals, and work together and complement each other while dividing tasks. Under such circumstances, registered dietitians are required to participate along with nurses, pharmacists, and clinical laboratory technicians in order to build a team medical system that provides medical care that appropriately responds to the situation of patients (sick patients). ing.

In order to overcome this current situation and challenges and smoothly realize cooperation between public municipal insurers and union insurers and local medical institutions, it is necessary to implement mandatory medical checkups. In order to increase the effectiveness of health care, we will not end with health guidance alone, but will prevent the disease from becoming more serious at the initial treatment stage by linking public examinations with clinical medical care. To this end, we need to create an environment in which public examinations can be accepted in clinical medical settings as part of clinical medical care by identifying only those adult diseases that the elderly inevitably suffer from as they age, among lifestyle-related diseases. is important. However, there is a clear line between prevention and treatment, and collaboration is not progressing as it stands.

In the current medical practice regarding medical treatment and therapeutic diets, information regarding the prescription and administration of medicines by doctors is exchanged based on a protocol formed in a common language among doctors, pharmacists, and nurses. Accurate information is communicated to pharmacists and nurses. In contrast, the food that registered dietitians handle is made up of a wide variety of animal and plant cells, and is prepared by combining many foods to prepare meals for patients, so there is no evidence of specific therapeutic effects. Not obtained. Therefore, the current situation is that it is difficult to build medical trust with doctors regarding meals for the sick.

Furthermore, although doctors have a conceptual understanding of the importance of food, they are aware that food for patients does not directly contribute to acute treatment, so they are less interested in it from a therapeutic perspective, and other Interactions with groups directly involved in treatment tend to be hindered, and even if team medical care is implemented, patients cannot escape from the sidelines.

Pharmacists and doctors share common knowledge regarding evidence regarding medicines for the treatment of acute diseases, a common language has been formed, and doctors' instructions are communicated in advance protocols. On the other hand, the foods (ingredients) included in meals for patients treated by registered dietitians cannot be seen from the perspective of immediate therapeutic effects, and the functionality of foods for patients as a treatment for specific diseases in the human body cannot be determined. Therefore, it is not possible to construct evidence. Furthermore, although there is a conceptual understanding of the importance of meals, doctors have little interest in therapeutic food, and it is easy to see it as an extension of daily meals.

In hospitals, registered dietitians work on preventing diseases, early recovery from diseases, and preventing aggravation of diseases based on basic nutrition and clinical nutrition, under the comprehensive guidance of doctors called the critical path. , is mainly responsible for the independent school lunch department. In general, registered dietitians do not deal with individual patients (sick patients), but rather provide meals at medical institutions, which tend to be group meals for general illnesses. Registered dietitians conceptually understand that food for patients (ingredients) for patients is important for maintaining health, but they do not have direct dialogue regarding treatment with doctors, who are the center of medical care. Not so much.

In order to continue to manage and supply medical food for outpatients at home after early discharge, registered dietitians must handle a variety of foods for patients that are developed based on clinical data that can prove their functionality. It is necessary to back up a registered dietitian.

The present invention was made based on the above-mentioned lifestyle-related diseases, effective diets for patients (therapeutic foods), and the situation in the medical field including doctors, registered dietitians, etc. .

That is, an object of the present invention is to provide a device and a program for selecting an appropriate herbal medicine for patients suffering from lifestyle-related diseases in order to recover the functions of lifestyle-related diseases.

In order to solve the above problems, the present invention has the following configuration.

(Configuration 1)
Configuration 1 of the present invention is a device for selecting a crude drug to be provided to a patient suffering from a lifestyle-related disease, and a device for inputting and storing the name of at least one drug prescribed to the patient. an input means, a crude drug input means for inputting and storing names of crude drugs, a first crude drug list storage unit for storing and associating drugs and crude drugs that are contraindicated for combination with the drugs; Compatible crude drug determination for searching the first crude drug list storage unit based on the crude drug and determining whether the crude drug (and ingredients other than the crude drug substrate, if necessary) and the drug are contraindicated for combination. and a result display means for displaying the determination result.

According to the device of configuration 1 of the present invention, since it is possible to avoid using herbal medicines (and herbal medicine-related ingredients, if necessary) that are contraindicated in combination with medicines for patients, it is possible to prevent lifestyle-related diseases Appropriate herbal medicines can be selected for recovery.

(Configuration 2)
Configuration 2 of the present invention provides that the device:
a second crude drug list storage unit for storing a drug in association with a crude drug expected to have a substitute effect for the drug;
a third crude drug list storage unit for storing a drug in association with a crude drug that complements the effect of the drug;
further comprising at least one storage section selected from a fourth crude drug list storage section for storing a drug and a crude drug that alleviates the side effects of the drug in association with each other;
The compatible crude drug determination means further searches the second crude drug list storage section, the third crude drug list storage section, and/or the fourth crude drug list storage section based on the drug and the crude drug, and determines whether the crude drug is expected to have a substitutive effect for the drug. The device of configuration 1 is further configured to determine whether the drug can be used, complement the effect of the drug, and/or alleviate the side effects of the drug.

According to configuration 2 of the present invention, in addition to being able to avoid using herbal medicines that are contraindicated in combination with medicines for patients, it is also possible to use herbal medicines that are expected to have a substitute effect for medicines, herbal medicines that supplement the effects of medicines, and/or herbal medicines that are It is possible to appropriately select crude drugs that alleviate side effects. Therefore, more appropriate crude drugs can be selected for patients suffering from lifestyle-related diseases to recover from them.

(Configuration 3)
Structure 3 of the present invention is that the herbal medicine is a herbal medicine for blending or adding to food for patients,
The food for the sick has ingredients that are other than the herbal drug base,
an ingredient input means for inputting and storing ingredients;
a first foodstuff list storage unit for storing medicines and foodstuffs that are contraindicated for the medicines in association with each other;
Compatible food determining means for searching a first food list storage unit based on the medicine and food and determining whether or not the food and the medicine are contraindicated for combination;
further comprising;
The result display means is the apparatus according to configuration 1 or 2, in which the result display means further displays the determination result of the compatible foodstuff determination means.

According to the device according to configuration 3 of the present invention, in food for sick patients in which crude drugs are blended or added, it is possible to determine whether or not the contraindications for incorporation with drugs are determined not only for the crude drugs but also for foodstuffs that are parts other than the crude drug base. be able to. Therefore, in foods for patients suffering from lifestyle-related diseases, it is possible to select not only appropriate herbal medicines but also appropriate ingredients.

(Configuration 4)
Configuration 4 of the present invention provides that the device:
a second foodstuff list storage unit for storing medicines in association with foodstuffs that are expected to have a substitute effect for the medicines;
a third food list storage unit for storing medicines in association with food ingredients that complement the effects of the medicines;
a fourth food list storage unit for storing medicines and food ingredients that alleviate the side effects of the medicines in association with each other;
further comprising at least one storage section selected from;
The compatible foodstuff determination means further searches the second foodstuff list storage section, the third foodstuffs list storage section, and/or the fourth foodstuffs list storage section based on the medicine and the foodstuff, and determines whether the foodstuff is expected to have a substitutive effect for the medicine. The device of configuration 3 is further configured to determine whether the drug can be used, complement the effect of the drug, and/or alleviate the side effects of the drug.

According to configuration 4 of the present invention, by having the device of the present invention having the above configuration, in addition to being able to avoid ingredients that are contraindicated for combination with the patient's medicine in food for the sick in which herbal medicines are mixed or added. Furthermore, it is possible to appropriately select foodstuffs that are expected to have a substitute effect for drugs, foodstuffs that complement the effects of drugs, and/or foodstuffs that alleviate side effects of drugs. Therefore, for patients suffering from lifestyle-related diseases, not only more appropriate herbal medicines but also more appropriate foodstuffs can be selected for recovery from lifestyle-related diseases.

(Configuration 5)
Configuration 5 of the present invention is the device according to configuration 3 or 4, wherein the food material is an excipient that is a part other than the crude drug base of the crude drug, and the food for patients is a tablet containing the crude drug.

According to the apparatus of configuration 5 of the present invention, information such as the incompatibility of excipients used in manufacturing tablets containing crude drugs with medicines for patients can be obtained. Therefore, it becomes possible to select appropriate excipients for tablets containing herbal medicines.

(Configuration 6)
Arrangements 6 of the present invention are arrangements 1 to 1, in which the herbal medicines and/or foodstuffs are herbal medicines and/or foodstuffs that have been recognized as having evidence by molecular nutrition based on molecular biology, molecular genetics, and molecular physiology. 5.

According to configuration 6 of the present invention, when the herbal medicine and/or food ingredients are found to have evidence based on scientific methods, medical personnel such as doctors are able to recommend them to patients suffering from lifestyle-related diseases. Appropriate herbal medicines and/or foodstuffs other than herbal drug substrates can be used for recovery from disease.

(Configuration 7)
Configuration 7 of the present invention is a program for selecting crude drugs to be provided to patients suffering from lifestyle-related diseases using an information processing device, comprising:
The information processing device has a first crude drug list storage unit for storing a drug and a crude drug that is contraindicated for combination with the drug in association with each other,
For information processing equipment,
a drug input process for inputting and storing the name of at least one drug prescribed to a patient;
A crude drug input process for inputting and memorizing the name of the crude drug;
Compatible crude drug determination processing for searching a first crude drug list storage unit based on the drug and the crude drug and determining whether or not the crude drug and the drug are contraindicated for combination;
Result display processing for displaying the determination results;
This is a program that executes.

By using the program of configuration 7 of the present invention, it is possible to avoid using herbal medicines that are contraindicated in combination with the patient's medicines. and/or foodstuffs other than herbal drug substrates can be selected.

(Configuration 8)
In configuration 8 of the present invention, the information processing device:
a second crude drug list storage unit for storing a drug in association with a crude drug expected to have a substitute effect for the drug;
a third crude drug list storage unit for storing a drug in association with a crude drug that complements the effect of the drug;
a fourth crude drug list storage unit for storing a drug in association with a crude drug that alleviates the side effects of the drug;
further comprising at least one storage section selected from;
Compatible crude drug determination process
searching a second crude drug list storage unit based on the drug and the crude drug, and determining whether the crude drug is a crude drug expected to have a substitute effect for the drug;
searching a third crude drug list storage unit based on the drug and the crude drug, and determining whether the crude drug (and/or food material other than the crude drug substrate) is a crude drug that complements the effect of the drug; and/ or The program according to configuration 7, further comprising: searching a fourth crude drug list storage unit based on the drug and the crude drug, and determining whether the crude drug is a crude drug that alleviates side effects of the drug.

According to configuration 8 of the present invention, by having the program of the present invention having the above configuration, in addition to being able to avoid using crude drugs that are contraindicated in combination with medicines for patients, it is also possible to avoid using crude drugs and medicines that are expected to have a substitute effect for medicines. It is possible to appropriately select crude drugs that complement the effects of drugs and/or alleviate the side effects of drugs. Therefore, more appropriate crude drugs can be selected for patients suffering from lifestyle-related diseases to recover from them.

(Configuration 9)
Structure 9 of the present invention is that the herbal medicine is a herbal medicine for blending or adding to food for patients,
The food for the sick has ingredients that are other than the herbal drug base,
The information processing device further includes a first foodstuff list storage unit for storing medicines and foodstuffs that are incompatible with the medicines in association with each other,
The program, to the information processing device,
Ingredient input processing for inputting and memorizing ingredients;
Compatible foodstuff determination processing for searching a first foodstuff list storage unit based on the medicine and food and determining whether or not the food and the medicine are contraindicated for combination;
further execute
The result display process is a program according to configuration 7 or 8, in which the result display process further displays the determination result of the compatible foodstuff determining means.

According to the program of configuration 9 of the present invention, in foods for sick patients in which crude drugs are blended or added, incompatibility with drugs is determined not only for crude drugs but also for foodstuffs that are parts other than the crude drug base. be able to. Therefore, in foods for patients suffering from lifestyle-related diseases, it is possible to select not only appropriate herbal medicines but also appropriate ingredients.

(Configuration 10)
In configuration 10 of the present invention, the information processing device:
a second foodstuff list storage unit for storing medicines in association with foodstuffs that are expected to have a substitute effect for the medicines;
a third food list storage unit for storing medicines in association with food ingredients that complement the effects of the medicines;
further comprising at least one storage unit selected from a fourth food list storage unit for storing a medicine and a food ingredient that alleviates the side effects of the medicine in association with each other;
Compatible ingredients determination process
searching a second food list storage unit based on the medicine and the food material, and determining whether the food material is a food material expected to have a substitute effect for the medicine;
searching a third food list storage unit based on the medicine and food ingredients and determining whether the food material is a food ingredient that complements the effect of the medicine; and/or searching a fourth food list storage unit based on the medicine and food ingredients; The program according to configuration 9 further includes searching the food list storage unit and determining whether the food material is a food material that alleviates the side effects of the drug.

According to configuration 10 of the present invention, by having the program of the present invention having the above configuration, in addition to being able to avoid ingredients that are contraindicated in combination with the patient's medicine in food for the sick in which herbal medicines are mixed or added. Furthermore, it is possible to appropriately select foodstuffs that are expected to have a substitute effect for drugs, foodstuffs that complement the effects of drugs, and/or foodstuffs that alleviate side effects of drugs. Therefore, for patients suffering from lifestyle-related diseases, not only more appropriate herbal medicines but also more appropriate foodstuffs can be selected for recovery from lifestyle-related diseases.

(Configuration 11)
Configuration 11 of the present invention is the program according to configuration 9 or 10, in which the food material is an excipient that is a part other than the crude drug base of a crude drug, and the food for patients is a tablet containing the crude drug.

According to the program of configuration 11 of the present invention, it is possible to obtain information such as contraindications of excipients used in manufacturing tablets containing herbal medicines in combination with medicines for patients. Therefore, it becomes possible to select appropriate excipients for tablets containing herbal medicines.

(Configuration 12)
Structure 12 of the present invention is structure 7 to 7, wherein the crude drug and/or food material is a crude drug and/or food material that has been recognized as having evidence by molecular nutrition based on molecular biology, molecular genetics, and molecular physiology. 11 programs.

According to configuration 12 of the present invention, medical personnel such as doctors can provide information on lifestyle-related diseases to patients suffering from lifestyle-related diseases when the herbal medicines/or foodstuffs are recognized as having evidence based on scientific methods. Appropriate herbal medicines/or foodstuffs can be used for recovery.

According to the present invention, a device and a program are provided for selecting an appropriate herbal medicine (and herbal medicine-related ingredients as necessary) for a patient suffering from a lifestyle-related disease to recover the disease function of the lifestyle-related disease. can do.

1 is a diagram showing an example of the configuration of an apparatus according to the present invention. FIG. 6 is a diagram showing an example of an additional configuration that can be used in the device of the present invention. 2 is a diagram showing another example of the configuration of the device of the present invention, and is a diagram showing an example in which the additional configuration shown in FIG. 2 is added to the example of the device shown in FIG. 1. FIG. It is a figure which shows an example of another structure of the compatible crude drug determination means which can be used for the apparatus of this invention. It is a figure which shows an example of another structure of the compatible foodstuff determination means which can be used for the apparatus of this invention. It is a figure showing an example of processing of a program of the present invention. FIG. 3 is a diagram showing an example of additional processing that can be used in the program of the present invention. 7 is a diagram showing another example of the processing of the program of the present invention, and is a diagram illustrating an example in which the additional processing shown in FIG. 7 is added to the example of the program shown in FIG. 6. FIG. It is a figure which shows an example of another processing form of the compatible crude drug determination process which can be used for the program of this invention. It is a figure which shows an example of another processing form of a compatible foodstuff determination process which can be used for the program of this invention. It is a schematic diagram showing the relationship between molecular biology and molecular nutrition in order to obtain academic grounds to prove the evidence of crude drugs and foodstuffs.

Embodiments of the apparatus and program of the present invention will be specifically described below. Note that the following embodiments are examples of embodying the present invention, and do not limit the present invention within its scope.

As used herein, "lifestyle-related diseases" refers to a group of diseases whose onset and progression are related to lifestyle habits such as eating habits, exercise habits, rest, smoking, and drinking. Specifically, it refers to diseases such as cancer, cardiovascular disease, diabetes, and chronic obstructive pulmonary disease (COPD).

As used herein, the term "sick person" refers to a person who has a predetermined disease. In particular, in this specification, a person suffering from a lifestyle-related disease may be simply referred to as a "sick person."

As used herein, "crude drugs" include crude drugs listed in the Japanese Pharmacopoeia, and include ingredients that are raw materials for Chinese herbal medicines.

As used herein, "food for sick people" refers to food included in meals for sick people. In this specification, foods containing herbal medicines are sometimes referred to as "foods for patients."

As used herein, "meal for the sick" refers to a meal for the sick that should be provided to the sick. In addition, ``meals for patients'' are sometimes referred to as ``therapeutic foods.'' Furthermore, in this specification, "meals for the sick" that include herbal medicines are sometimes referred to as "medicinal meals."

In this specification, materials for making meals for patients and foods for patients are referred to as "ingredients." Furthermore, in this specification, food for the sick and foodstuffs may be used interchangeably.

As used herein, "excipient" refers to an additive added for handling, molding, etc. of a pharmaceutical product. Since lactose and starch are commonly used as excipients, excipients are treated as a type of food material in this specification. Since what has the efficacy of a crude drug is the base part, the parts of the crude drug other than the base part of the crude drug are treated as excipients. In addition, tablets containing herbal medicines are treated as a type of food for the sick, as they contain the herbal medicine base and excipients (ingredients).

In this specification, the term "information processing device" refers not only to a device such as a single computer, but also to a device that processes information by connecting other devices connected via a communication line such as a local network or the Internet. Contains network concepts for

In this specification, "storing" means "storing" information in a "storage unit" such as the memory and hard disk of an information processing device, or the inside of another device connected to a communication line such as a local network or the Internet. This refers to writing and storing the information in a readable manner until the specified processing by the device and program is completed.

In this specification, the term "storage section" refers to a device, such as a memory or a hard disk, into which input information can be written in a readable manner. The storage unit can be placed inside a predetermined device. Further, the storage unit can exist inside another device connected to a local network or a communication line such as the Internet.

In this specification, the "input means" used for pharmaceutical input means and herbal medicine input means uses known input devices such as a keyboard, voice input, and selection from a pull-down menu using a pointing device such as a mouse. be able to. Further, as the input means, data transfer from another information processing device to the information processing device of this embodiment can be used. The same applies to other input means.

In this specification, the "result display means" may be any known display means such as a display, a printing device, an audio output device, and output to the outside via a communication line such as a local network or the Internet. . In other words, the result display means not only has the information processing device of this embodiment have a display device, but also has the ability to transmit data (results) to other information processing devices. Including displaying results.

In order to smoothly realize cooperation between public municipal insurers, union insurers, and local medical institutions, it is necessary to identify lifestyle-related diseases that especially affect the elderly. It is important to create an environment where public examinations can be accepted in clinical medical settings as a scope of clinical medical care by specifying only adult diseases. However, there is a distinction between prevention and treatment, and the current situation is that collaboration is not progressing as it stands.

In order to increase the effectiveness of compulsory health checkups for lifestyle-related diseases, it is necessary to prevent diseases from becoming more serious at the initial treatment stage by linking public checkups to clinical medical care sites, rather than just providing health guidance. It is necessary. In addition, for adult diseases such as diabetes and other lifestyle-related diseases that inevitably occur as people age, regardless of whether they are in the early or late stages of old age, it is important to prevent the disease from becoming more serious at the initial treatment stage.

In the present invention, first, as part of clinical treatment, a doctor submits a critical path to a registered dietitian in the NST (nutrition support team, nurses, pharmacists, registered dietitians, etc.), and asks the dietitian to provide treatment for each disease. It is necessary to clarify the division of labor by indicating the contents of the tests and creating unique nutritional recipes. Furthermore, unlike a doctor issuing a prescription for medicine, it is necessary to clarify the legal standard that therapeutic foods are not medicines that are used and supplied based on a doctor's prescription or instructions.

As part of treatment, it is essential to be able to verify the risks of interactions and incompatibility with functional therapeutic foods (herbal medicines, food ingredients, etc.) provided to patients at the same time as therapeutic drugs, based on scientific evidence. Furthermore, it must be approved by the medical and nutritional sciences concerned with functional foods (herbal medicines, food ingredients, etc.), and must have an academic basis to prove the evidence. As shown in Figure 11, it is necessary to connect medicine and nutrition through molecular nutrition, introduce scientific verification based on molecular biology, and establish evidence for both. In Figure 11, molecular genetics refers to medical research such as transmission of genetic information, protein synthesis and regulation, and molecular physiology refers to metaomics for elucidating mechanisms such as enzyme action and metabolism. , understanding in agricultural and nutritional technology.

In recent precision medicine, which is the basis for this theory, there is a hierarchical pattern that includes molecular mechanisms, therapeutic drugs, susceptibility, lifestyle, environmental factors, prognosis and outcome, and it is important to understand each patient's individual disease. Research into tailored personalized medicine has made it clear that diseases are caused not only by genetic predisposition but also by the interaction of environmental and lifestyle factors. As a result, it has become possible to open up a new category of lifelong health management based on the functionality of food ingredients for patients.

The next important issue is whether it is possible to establish evidence for functional therapeutic foods (herbal medicines, ingredients, etc.) that is similar to that of modern medicine. From a medical perspective on drug safety, drugs are developed with specific expectations for target organs that exhibit drug efficacy. For pharmaceuticals, the risk of interaction has been verified based on the strict drug trial testing known as toxicology, in which any action other than expected is defined as a side effect.

While pharmaceuticals have been scientifically verified and are reliable, functional foods with an organic composition (herbal medicines, foodstuffs, etc.) are based on nutrients and gene expression analysis based on molecular biology and biochemistry. Scientific evidence from nutritional science is recognized by the medical side, and it is possible to verify interaction with pharmaceuticals and contraindications for combination. Clinical trials are essential for drug development, but in the case of crude drugs, I would like to praise the fact that their medicinal efficacy has been confirmed in medical clinical trials over a long history, which is comparable to pharmaceutical trials.

There is a demand from the functional food industry for a more in-depth labeling of functionality in terms of prevention. Amid this trend in the industry, there are products that are defective and counterfeit, products that are labeled as pharmaceuticals but have not been approved, and products that are labeled as food but are considered to be pharmaceuticals. In order to clearly differentiate such functional foods from unapproved, unlicensed pharmaceuticals, guidance, and control drugs, the Pharmaceutical Affairs Law was revised to establish licensing standards for foods with nutritional function claims, and to include them in the Japanese Pharmacopoeia. Among the registered herbal medicines, a public notice has been issued stating that unless they claim medicinal effects, they will not be considered medicines and can be treated as food.

Among the specified health foods, there are also functional foods that contain indigestible dextrin. If a patient on medication takes such functional foods without informing the doctor, if the cardiotonic drug digitalis or the anti-solid drug warfarin is administered, they will be absorbed into the dietary fiber, reducing the drug's efficacy. A problem arises. In addition, when grapefruit juice, which is a regular food, is administered, half of the prescription drugs that are metabolized by drug-metabolizing enzymes are inhibited by intracellular cytochrome P450, which increases the absorption of drugs. Been warned.

In the field of community medical care, where people receive medication treatment either at the hospital or at home, many elderly people are taking functional foods from the market without their doctors' knowledge and are outside the control of their doctors. As calls are being made to curb soaring medical costs for the elderly, medical treatment by a doctor is essential to prevent the onset and severity of the disease through early treatment, and dietary therapy to improve the environment and eating habits is also effective. It is necessary to proceed to When a therapeutic treatment using a combination of therapeutic drugs is performed, it is a part of the treatment, and since the drug is administered, it is possible to check the interaction between the therapeutic food and the drug in advance. The first major medical principle is to verify the risks of interaction and contraindications with therapeutic functional foods.

Food is a collection of many ingredients, and it contains many unknown ingredients, and ingesting food causes changes in digestive motility and sugar content in the blood, making it more complex than in the case of drugs. Become. The crude drugs registered in the Japanese Pharmacopoeia are considered to be equivalent to clinical trials for pharmaceuticals. Among herbal medicines, which are natural resource medicines that have already been clinically recognized, they can be classified as non-medical list foods under the Pharmaceutical Affairs Law. Among the herbal medicines registered in the Japanese Pharmacopoeia as medicines, it is necessary to first establish a new genre of medicinal foods by establishing software to verify interactions between Chinese herbal foods and medicines and verifying legal compliance. It is.

Next, a part of the Pharmaceutical Affairs Law has been revised, creating a non-medical list for crude drugs and giving them permission to use them as general functional foods, but if a doctor is involved, they will be considered drugs and subject to regulation. However, under the supervision and direction of doctors, it is possible to develop medicinal functional foods that utilize the effective parts of whole medicinal plants, which are called side dishes and medicinal dishes, even among the herbal medicines contained in Chinese herbal medicines. can. As a nutritionally functional food whose medicinal effects are managed only by medical professionals, it is important to make it possible to cite it as index material only for medical professionals, based on the scientific analysis information of the Japanese Pharmacopoeia of crude drugs. be. For example, it is important to use molecular nutrition to analyze ingredients that are taken into the body as short-chain fatty acids, which are metabolized in the human large intestine, and which are taken into the body as low plant metabolic molecules, and to disclose information that can display scientific evidence. be.

Even though they are not regulated by the Pharmaceutical Affairs Law, when looking at the basic differences in safety between functional foods and drugs, from a medical perspective, it is of course impossible to verify the side effects of drugs used in treatment. As mentioned above, functional foods cannot currently enter the medical field. If you buy and take supplements that claim to have functional properties without your doctor's knowledge, they may interfere with circulatory system diseases such as hypertension and angina pectoris, and conversely, blood thinners such as warfarin, an anticoagulant, may interfere with circulatory system diseases such as hypertension and angina pectoris. There are also reports that it is adsorbed by dextrin in food, making it difficult for it to be absorbed into the body from the digestive tract, inhibiting improvement of symptoms, and leading to aggravation of the disease.

The present invention does not end medical examinations for the elderly with insurance guidance, but connects them to clinical treatment and enhances the effectiveness of medical examinations. As part of this, we will promote medical treatment while providing guidance and managing supply as a functional food for medical treatment. It is necessary to ensure patient safety by avoiding the risk of combinations and mutual contraindications between drugs prescribed by doctors and functional foods similar to drugs. In order to formulate a checklist for this purpose, it is important to prepare data to verify and check interactions of functional foods with drugs based on evidence. In addition, it is important to ensure patient safety by obtaining a list of contraindications, which can be indexed and checked by medical personnel as necessary.

In the device and program of the present invention, a doctor communicates the medical condition and treatment purpose to the NST (Nutritional Support Team), communicates the treatment policy, and creates a recipe by a registered dietitian who receives instructions regarding nutritional management. It can be used for. To this end, it is essential to clarify the functional information of foods. Based on the basic information, we use the molecular biology of the food in question to elucidate the mechanism of enzymatic action, metabolism, etc. in the fields of agriculture and nutrition, and then we use this information to obtain genetic information in the medical field, medical technology such as protein synthesis, etc. By elucidating this, we can turn the evidence shared by both medicine and agriculture into software, and in some cases, make it possible to make full use of AI and IoT.

It is important to build evidence that the therapeutic functional foodstuffs (herbal medicines, foodstuffs) that are the core of the present invention can be used in combination with pharmaceuticals. For the first time, it will be possible to supply therapeutic food based on Chinese herbal prescriptions and herbal medicines listed as non-medical, based on the evidence sought by medical websites for therapeutic food. Preferably, the device and program of the present invention are limited to limited use in medical settings. To achieve this, it is necessary to gain the trust of the medical side. Looking at the development history of pharmaceuticals, we can see that they originally involved analyzing the functions of medicinal plants such as crude drugs and Chinese herbal medicines, leading to chemical synthesis. It is first necessary to commercialize functional foods using herbal medicines on the non-medical list, but the use of herbal medicines has so far only been based on empirical rules. It is important to build a higher level of evidence by doing so.

The target disease of the present invention is to prevent the onset of the disease through initial medical treatment. Specifically, we will focus on multifactorial diseases such as diabetes, hypertension, and kidney disease, which are lifestyle-related diseases. As an example of how to use herbal medicines to treat diabetes, herbal medicines such as chimo, ousei, and mulberry bark are used to treat hyperlipidemia associated with obesity, and bukryo is used to treat chronic nephritis. ), chorei (wild boar), taksha (sawa 瀉), mokutsu (kidori), sandalwood (byakujutsu), lotus root (lotus grass), and kagosou (summer dry grass). In addition, blood pressure and cardiovascular diseases include Kouboku, Senso, Digitalis, etc. Although the chemical formulas and clinical effects of the main components of each crude drug in foods including these have been disclosed, there is no molecular biological analysis, so scientific research is needed through higher-dimensional meta-omics analysis than normal genome analysis. It is necessary to establish evidence that

In order to widely return information on medical-related businesses to society, we will use this basic information to theoretically back up medicinal dishes and create a genre of therapeutic food aimed at preserving the health and function of the general elderly. It is important to explore. Among the natural drugs listed in the Japanese Pharmacopoeia and the herbal medicines included in Chinese herbal medicines, many are also recognized as edible, including prepared foods, sweeteners, and flavorings. Although herbal medicines do not have the sharp medicinal effects of synthetic drugs, they have fewer side effects and are ideal as ingredients for therapeutic foods aimed at restoring organ homeostasis and function. The present invention theoretically backs up medicinal cuisine-style therapeutic foods that make use of the medicinal properties of plants, not just limited specific parts as herbal medicines, thereby reducing costs and widely preventing diseases. We can support the development of therapeutic foods to support the elderly, including elderly people, and contribute to the realization of a healthy and long-lived society.

The medical care service that is assembled based on this technical information verifies the interaction between medicines and therapeutic functional foods, and registered dietitians create unique recipes based on nutritional science based on instructions from doctors or critical paths. has been issued. However, there is no mechanism for doctors to check the improvement progress of patients who have received the recipe, and a system is needed to improve the situation. Therefore, in addition to pooling patient search information that proves whether the functional foods selected by registered dietitians are composed of reliable substances similar to medicines, doctors also need to track patients' intake history of medicines and therapeutic foods. A system that can be checked at any time depending on the situation must be essential for home medical care. The present invention is important for providing that system.

The device and program of the present invention are intended to be disclosed only to persons involved in medical care such as doctors, registered dietitians, nurses, pharmacists, etc. of medical institutions, and are intended to be disclosed only to persons involved in medical care such as doctors, registered dietitians, nurses, pharmacists, etc. This distinguishes it from food with functional claims as required by law. Furthermore, in view of the Pharmaceutical Affairs Law's regulation that ``medical drugs are drugs intended to be used by a doctor or dentist, or by prescription or instruction from a doctor or dentist,'' the present invention The instructions in the protocol or critical path, which is the work of I think that there is no conflict with. However, searching for scientific information on the functional foods selected and recommended by nutritionists is within the scope of a doctor's normal work, and this invention was made on the premise that this medical-related information will not be disclosed to the public. ing.

The present invention combines the results of compulsory public medical examinations with clinical treatment, which is a task that has not been done in the past. Therefore, the purpose of this study is to create a device and program to avoid the risk of contraindications between foods that are expected to be selected and drugs administered to patients. In addition, given the position of foods (herbal medicines, ingredients) that are involved in treatment, it is necessary to prove the evidence of foodstuffs required by the medical side. The purpose is to provide devices and programs that contain information that can be searched by medical personnel. Furthermore, since the origin of modern medicines is chemical synthesis based on the effects of natural medicinal herbs (herbal medicines), it can be said that herbal medicines have a reliability that ordinary foodstuffs do not have. Therefore, we aim to position functional therapeutic foods based on herbal medicines and present methods to establish evidence for herbal medicines and foodstuffs through metagenomic analysis included in molecular nutrition. In addition, we will utilize metagenomic analysis technology, which is lacking even in Chinese herbal medicine, to provide therapeutic functional foods for the elderly based on scientific data, for medicinal dishes whose therapeutic effects have been shown only empirically until now. The purpose is to provide a method that makes it possible.

In view of the above situation, the inventors of the present invention conceived of the apparatus and program described below.

Next, embodiments of the device of the present invention will be described.

FIG. 1 shows one aspect of the device of this embodiment. The device of this embodiment is a device for selecting crude drugs to be provided to patients suffering from lifestyle-related diseases. This device includes a drug input means, a crude drug input means, a first crude drug list storage section, a suitable crude drug determination means, and a result display means. According to this device, it is possible to avoid using crude drugs that are contraindicated in combination with the patient's medicines, so it is possible to select appropriate crude drugs for the recovery of lifestyle-related diseases for patients suffering from lifestyle-related diseases. .

The drug input means is configured to input and store the name of at least one drug prescribed to a patient. The drug input means may also be configured to further input and store a prescribed dosage of the drug.

Prescribed medicines and prescribed doses of the medicines are prescribed by a doctor depending on the type of disease (lifestyle-related disease) and its progress.

The crude drug input means is configured to input and store the name of the crude drug. It can be a crude drug to be added to meals for sick people or foods for sick people.

Note that the herbal medicine input means is not necessarily necessary, and it is also possible to apply the compatible herbal medicine determination means described below based on information about only the medicine obtained by the medicine input means. Moreover, conversely, the drug input means is not necessarily necessary, and it is also possible to apply the compatible crude drug determination means described below based on information about only the crude drug obtained by the crude drug input means. Therefore, in the apparatus of this embodiment, at least one selected from pharmaceutical input means and herbal medicine input means is required as the input means.

The first crude drug list storage unit is configured to store a drug and a crude drug that is incompatible with the drug in association with each other.

The first crude drug list storage section is a storage section for storing, in a searchable manner, a drug and a crude drug that is incompatible with the drug in association with each other. The first crude drug list storage unit is basically capable of searching for a drug and a crude drug that is contraindicated in combination with the drug, a drug that is contraindicated in combination with the drug, or a crude drug that is contraindicated in combination with the drug. This is a list created and stored as follows.

The compatible crude drug determination means is configured to search the first crude drug list storage section based on the drug and the crude drug, and determine whether or not the crude drug and the drug are contraindicated for combination. The compatible herbal medicine determination means can determine whether or not the input herbal medicine and the prescribed drug are contraindicated for combination, based on the search results in the first herbal medicine list storage unit.

The Ministry of Health, Labor and Welfare's Comprehensive Research Project on Regulatory Science for Pharmaceuticals and Medical Devices is conducting research to review the risk categories of chemically synthesized products in over-the-counter drugs and to ensure the safety of herbal medicine preparations. The "Confirmation Sheet for Chinese Herbal Prescriptions for Safe Use" obtained from these research results will be linked with the processing software, and will be used as the first crude drug list storage unit to integrate with pharmaceutical products, including external databases. It is possible to prepare an option of activating a combination contraindication determination means. In this case, communication means such as the Internet can be used as the communication means for accessing the first herbal medicine list storage section placed outside. Further, the first crude drug list storage section can be accessed externally by the combination contraindication determination means. Similar configurations can be applied to other storage units and determination means.

In addition, if there is no crude drug input method and information regarding crude drugs has not been entered, the compatible crude drug determination method will check all of the crude drugs that are contraindicated for combination with the drug, based on the information on only the drug obtained by the drug input method. It is also possible to obtain the list as a list. In addition, if there is no drug input means and no information regarding drugs has been entered, the compatible crude drug determination means will check all drugs that are contraindicated for combination with crude drugs, based on the information on only crude drugs obtained by the crude drug input means. It is also possible to obtain the list as a list.

FIG. 4 shows another embodiment of the compatible crude drug determining means. In the embodiment shown in FIG. 4, the device includes, in addition to the first crude drug list storage section, at least one memory selected from a second crude drug list storage section, a third crude drug list storage section, and a fourth crude drug list storage section. The device may further include a section.

The first crude drug list storage unit is similar to the embodiment shown in FIG.

The second crude drug list storage unit is configured to associate and store a drug and a crude drug that is expected to have a substitute effect for the drug. When the device has a second crude drug list storage section, the compatible crude drug determination means further searches the second crude drug list storage section in addition to the first crude drug list storage section based on the drug and the crude drug, and determines whether the crude drug is It can be further configured to determine whether or not a substitute effect of a drug can be expected.

The third crude drug list storage unit is configured to associate and store a drug and a crude drug that complements the effect of the drug. When the device has a third herbal medicine list storage unit, the compatible herbal medicine determination means is further configured to further search the third herbal medicine list storage unit and determine whether the herbal medicine complements the effect of the medicine. can be done.

The fourth crude drug list storage unit is configured to associate and store a drug and a crude drug that alleviates the side effects of the drug. When the device has a fourth herbal medicine list storage unit, the compatible herbal medicine determination means is further configured to further search the fourth herbal medicine list storage unit and determine whether the herbal medicine alleviates the side effects of the medicine. can be done.

By further including at least one storage section selected from the second crude drug list storage section, the third crude drug list storage section, and the fourth crude drug list storage section, the device of the present embodiment is expected to further provide a drug substitution effect. It is possible to appropriately select a herbal medicine that supports the patient, a herbal medicine that complements the effects of the medicine, and/or a herbal medicine that alleviates the side effects of the medicine. Therefore, more appropriate crude drugs can be selected for patients suffering from lifestyle-related diseases to recover from them.

The result display means is configured to display the determination result.

The result display means determines whether the input herbal medicine (and, if necessary, food based on the herbal medicine) is contraindicated for combination with the prescribed medicine, by the compatible herbal medicine determination means. be able to. Medical personnel, such as doctors and registered dietitians, can select a crude drug by referring to this determination result. Further, the result display means can appropriately select the display results. That is, only the selected herbal medicines determined by the compatible herbal medicine determining means can be displayed, or the unselected herbal medicines can be displayed together with the reason thereof. Further, the determination result can also be displayed together with the content input by the input means.

As shown in FIG. 2, it is preferable that the apparatus of this embodiment has a means for determining contraindications to the medicine for a sick person, etc. for foodstuffs as well as for herbal medicines. Note that FIG. 3 shows the configuration of an apparatus in which the configuration related to foodstuffs shown in FIG. 3 is added to the apparatus of this embodiment shown in FIG. 1.

The configuration (foodstuff determining means) shown in FIG. 2 determines which foodstuffs are to be blended or added to foods for sick people, along with herbal medicines. Specifically, in addition to the medicine input means and result display means that are common to the device shown in FIG. 1, the foodstuff determination means includes a foodstuff input means, a first foodstuff list storage section, and a compatible foodstuff determination means.

The drug input means is common to the device shown in FIG. 1, and is configured to input and store the name of at least one drug prescribed to a patient.

The ingredients input means is configured to input and store ingredients.

The first foodstuff list storage section is a storage section for storing, in a searchable manner, medicines and foodstuffs that are incompatible with the medicines in association with each other. The first food list storage unit is basically capable of searching for a medicine and a food ingredient that is contraindicated for combination with the medicine, a food ingredient that is contraindicated from a medicine, or a medicine that is contraindicated for combination from a food ingredient. This is a list created and stored as follows.

The compatible foodstuff determination means is configured to search the first foodstuff list storage unit based on the medicine and the food and determine whether or not the combination of the food and medicine is contraindicated. The compatible foodstuff determination means can determine whether or not the inputted foodstuff and the prescribed medicine are incompatible with each other, based on the search results in the first foodstuff list storage section.

The result display means is common to the apparatus shown in FIG. 1, and is configured to further display the determination result of the compatible foodstuff determination means. The method of displaying the determination results for foodstuffs is the same as the determination results for crude drugs.

By determining whether or not ingredients and medicines are contraindicated for combination, it is possible to determine whether or not there is a contraindication for mixing ingredients with medicines, in foods for patients in which crude drugs have been blended or added, not only crude drugs but also ingredients other than the crude drug base. It is also possible to determine contraindications for drug combination. Therefore, in foods for patients suffering from lifestyle-related diseases, it is possible to select not only appropriate herbal medicines but also appropriate ingredients.

FIG. 5 shows another embodiment of the compatible foodstuff determining means. In the embodiment shown in FIG. 5, the device includes, in addition to the first food list storage, at least one storage selected from a second food list storage, a third food list storage, and a fourth food list storage. It is possible to further include the following.

The first food list storage unit is similar to the embodiment shown in FIG.

The second foodstuff list storage unit is configured to associate and store medicines and foodstuffs that are expected to have a substitute effect for the medicines. When the device has a second foodstuff list storage section, the compatible foodstuff determination means further searches the second foodstuffs list storage section based on the medicine and foodstuff, and determines whether the foodstuff can be expected to have a substitutive effect for the medicine. can be further configured to determine.

The third foodstuff list storage unit is configured to store medicines and foodstuffs that complement the effects of the medicines in association with each other. When the device has a third foodstuff list storage section, the compatible foodstuff determination means is further configured to further search the third foodstuff list storage section and determine whether the foodstuff complements the effect of the medicine. can be done.

The fourth foodstuff list storage unit is configured to store medicines and foodstuffs that alleviate the side effects of the medicines in association with each other. When the device has a fourth foodstuff list storage section, the compatible foodstuff determination means is further configured to further search the fourth foodstuff list storage section and determine whether the foodstuff alleviates the side effects of the medicine. can be done.

The device of this embodiment further includes at least one storage section selected from the second food list storage section, the third food list storage section, and the fourth food list storage section, so that In food for patients, in addition to avoiding ingredients that are contraindicated in combination with medicines for patients, it is possible to include ingredients that are expected to have a substitute effect for medicines, ingredients that complement the effects of medicines, and/or ingredients that alleviate the side effects of medicines. Can be selected appropriately. Therefore, for patients suffering from lifestyle-related diseases, not only more appropriate herbal medicines but also more appropriate foodstuffs can be selected for recovery from lifestyle-related diseases.

In the device of this embodiment, it is preferable that the food material is an excipient that is a part other than the crude drug base of the crude drug, and that the food for patients is a tablet containing the crude drug. According to the apparatus of this embodiment, it is possible to obtain information such as contraindications of excipients used in manufacturing tablets containing herbal medicines for patients with medicines. Therefore, it becomes possible to select appropriate excipients for tablets containing herbal medicines.

In the device of this embodiment, the herbal medicine/foodstuff is a herbal medicine and/or food containing a herbal medicine that has been recognized as having evidence by molecular nutrition based on molecular biology, molecular genetics, and molecular physiology. preferable. By recognizing that herbal medicines have evidence based on scientific methods, medical professionals such as doctors can use appropriate herbal medicines to help patients with lifestyle-related diseases recover from lifestyle-related diseases. I can do it. In addition, it is preferable that the above-mentioned foodstuffs are also recognized as having evidence based on molecular nutrition based on molecular biology, molecular genetics, and molecular physiology.

Further, the device of this embodiment can include an additional information storage unit regarding evidence of crude drugs and food ingredients.

The supplementary information storage unit regarding the evidence of crude drugs and foodstuffs refers to the above-mentioned crude drugs and foodstuffs that are contraindicated for combination with medicines, herbal medicines and foodstuffs that are expected to have a substitute effect for medicines, herbal medicines and foodstuffs that complement the effects of medicines, and the side effects of medicines. This is information that shows the scientific basis for herbal medicines and foodstuffs that provide relief, for example, information on bibliographic items such as academic literature and their descriptions regarding herbal medicines and foodstuffs that are contraindicated in combination with medicines. Additional information regarding evidence of crude drugs and foodstuffs is associated with the corresponding first to fourth crude drug list storage units and first to fourth food list storage units, and is stored in ancillary information storage unit regarding evidence of crude drugs and foodstuffs such as clinical trials. can be memorized. Physicians, etc. may need to check the evidence when selecting herbal medicines and food ingredients according to the protocol. Therefore, in the device of this embodiment, when a doctor or the like needs additional information regarding evidence of a given herbal medicine or food ingredient, the information is read out from the additional information storage unit regarding the evidence of the herbal medicine or food ingredient by searching and displayed. Preferably, the device is configured to do so. Furthermore, it is preferable that nurses, pharmacists, and registered dietitians in the NST (Nutrition Support Team) group share the same information with doctors.

In the device of this embodiment, the food for the sick (ingredients) is a special purpose food, an individual evaluation type food for the sick, a permit standard type food for the sick, or a food for the sick that is recognized as having sufficient evidence by a doctor or medical personnel. Preferably, the food is If the food for the sick (ingredients) is a food for special purposes, an individually evaluated food for the sick, a permit standard food for the sick, or a food that has been recognized as having sufficient evidence by a doctor or medical professional, This is because the scientific basis for the effects of foods (ingredients) for the sick and the ingredients involved is relatively clear.

The device of this embodiment is preferably managed so that it can be used only by medical personnel (doctors, pharmacists, registered dietitians, etc.) and functions as a black box for medical personnel. The selection of crude drugs that have medicinal effects and the selection of ingredients that are expected to have medicinal effects may be medical procedures and may need to be used under the supervision of an appropriate expert. It's for a reason.

Next, with reference to FIG. 6, an embodiment of the program of the present invention will be described.

FIG. 6 shows one aspect of the program of this embodiment. By executing the program of this embodiment by an information processing device, it is possible to avoid using herbal medicines that are contraindicated in combination with medicines for patients. Be able to select appropriate herbal medicines.

As shown in FIG. 6, the information processing device for executing the program of this embodiment includes a first crude drug list storage section. The first crude drug list storage unit is the same as that described for the apparatus of this embodiment above.

As shown in FIG. 6, the program of this embodiment causes the information processing device to execute drug input processing, crude drug input processing, compatible crude drug determination processing, and result display processing.

In the drug input process, a program instructs an information processing device to input and store the name of at least one drug prescribed to a patient (and, if necessary, the prescribed dosage of that drug). Let it run. Input of predetermined items can be performed from the drug input means of the embodiment of the device described above.

In the herbal medicine input process, the program causes the information processing device to execute a process to input and store the name of the herbal medicine. Input of predetermined items can be performed using the herbal medicine input means of the embodiment of the apparatus described above.

Note that the crude drug input process is not necessarily necessary, and it is also possible to apply the compatible crude drug determination process, which will be described later, based on information about only the drugs obtained by the drug input process. Conversely, the drug input process is not necessarily necessary, and it is also possible to apply the compatible crude drug determination process, which will be described later, based on information about only the crude drug obtained by the crude drug input process. Therefore, in the program of this embodiment, at least one selected from pharmaceutical input processing and crude drug input processing is required as input processing.

In the compatible crude drug determination process, the program instructs the information processing device to search the first crude drug list storage unit based on the drug and the crude drug, and determine whether or not the crude drug and the drug are contraindicated for combination. and execute the process.

In addition, if there is no crude drug input process and no information regarding crude drugs is entered, the compatible crude drug determination process will check all crude drugs that are contraindicated for combination with the drug, based on the information on only the drug obtained by the drug input process. It is also possible to use a processing format in which the information is obtained as a list. In addition, if there is no drug input process and no information regarding drugs has been entered, all drugs that are contraindicated for combination with crude drugs will be checked by the compatible crude drug determination process based on the information about only the crude drugs obtained by the crude drug input process. It is also possible to use a processing format in which the information is obtained as a list.

In the result display process, the program causes the information processing device to execute a process to display the determination result. The determination result can be displayed on the result display means of the embodiment of the apparatus described above.

By using the program of this embodiment, it is possible to avoid using crude drugs that are contraindicated in combination with the patient's medicines, so appropriate crude drugs can be selected for patients suffering from lifestyle-related diseases to recover from lifestyle-related diseases. can do.

FIG. 9 shows another embodiment of the compatible crude drug determination process. In the embodiment shown in FIG. 9, the information processing device includes at least one crude drug list storage section selected from the second crude drug list storage section, the third crude drug list storage section, and the fourth crude drug list storage section in addition to the first crude drug list storage section. The device may further include two storage units. The second crude drug list storage section, the third crude drug list storage section, and the fourth crude drug list storage section are the same as those in the embodiment of the apparatus described above.

When the information processing device has a second crude drug list storage section, in the compatible crude drug determination process, in addition to the first crude drug list storage section, the second crude drug list storage section is further searched based on the drug and the crude drug, and the second crude drug list storage section is searched based on the drug and the crude drug. However, the program of the present embodiment can cause the information processing device to execute a process to determine whether or not a drug substitution effect can be expected.

When the information processing device has a third crude drug list storage unit, in the compatible crude drug determination process, the third crude drug list storage unit is further searched to determine whether or not the crude drug complements the effect of the medicine. The program of this embodiment can cause an information processing device to execute a process.

When the information processing device has a fourth crude drug list storage unit, in the compatible crude drug determination process, the fourth crude drug list storage unit is further searched to determine whether or not the crude drug alleviates the side effects of the medicine. The program of this embodiment can cause an information processing device to execute a process.

The information processing device further includes at least one storage section selected from the second crude drug list storage section, the third crude drug list storage section, and the fourth crude drug list storage section, so that the program of the present embodiment can further: It is possible to appropriately select a crude drug that is expected to have a substitute effect for a drug, a crude drug that complements the effect of a drug, and/or a crude drug that alleviates the side effects of a drug. Therefore, more appropriate crude drugs can be selected for patients suffering from lifestyle-related diseases to recover from them.

The program of this embodiment can cause the result display means of the information processing apparatus to execute a process to display the determination result.

As shown in FIG. 7, it is preferable that the program of the present embodiment performs a process of determining contraindications in combination with medicines for patients, etc. for foodstuffs as well as for herbal medicines. Note that FIG. 8 shows the configuration of a program in which the processing related to foodstuffs shown in FIG. 7 is added to the program of this embodiment shown in FIG. 6.

In the process shown in FIG. 7 (foodstuff determination process), foodstuffs to be blended or added to food for the sick, along with herbal medicines, are determined. Specifically, the foodstuff determination process performs a foodstuff input process and a compatible foodstuff determination process in addition to the drug input process and result display process that are common to the program shown in FIG. Note that, in order to implement the compatible foodstuff determination process, the information processing device includes a first foodstuff list storage section. Note that the first ingredients list storage unit is similar to the first ingredients list storage unit in the embodiment of the device described above.

The drug input process is common to the program shown in FIG. 6, and the process is performed so that the name of at least one drug prescribed to a patient is input and stored.

The compatible foodstuff determination process is performed so as to search the first foodstuff list storage unit based on the medicine and food and determine whether or not the food and medicine are contraindicated for combination. Through the compatible foodstuff determination process, it is possible to determine whether or not the inputted foodstuff and the prescribed medicine are incompatible with each other based on the search results in the first foodstuff list storage section.

The result display process is the same as the result display process shown in FIG. 6, and the process is performed so as to further display the determination result of the compatible foodstuff determining means. The method of displaying the determination results for foodstuffs is the same as the determination results for crude drugs.

By determining whether or not ingredients and medicines are contraindicated for combination, it is possible to determine whether or not there is a contraindication for mixing ingredients with medicines, in foods for patients in which crude drugs have been blended or added, not only crude drugs but also ingredients other than the crude drug base. It is also possible to determine contraindications for drug combination. Therefore, in foods for patients suffering from lifestyle-related diseases, it is possible to select not only appropriate herbal medicines but also appropriate ingredients.

FIG. 10 shows another embodiment of the compatible foodstuff determination process. In the embodiment shown in FIG. 10, the information processing device stores, in addition to the first food list storage, at least one selected from the second food list storage, the third food list storage, and the fourth food list storage. It can further include a storage section. The second to fourth food list storage units are similar to those in the embodiment of the apparatus described above.

When the information processing device has a second foodstuff list storage section, in the compatible foodstuff determination process, the second foodstuffs list storage section is further searched based on the medicine and foodstuff, and whether the foodstuff can be expected to have a substitutive effect for the medicine. Further processing may be performed to determine whether or not.

When the information processing device has a third food list storage unit, in the compatible food product determination process, the third food list storage unit is further searched to determine whether or not the food supplements the effect of the medicine. Further processing can be performed.

In the case where the information processing device includes a fourth food ingredient list storage unit, in the compatible food ingredient determination process, the fourth food ingredient list storage unit is further searched to determine whether the food material alleviates the side effects of the medicine. Further processing can be performed.

By carrying out the above processing, the program of this embodiment can avoid ingredients that are contraindicated for the patient's medicine in food for the sick containing crude drugs or added to it, and can also provide substitutes for the medicine. Foods expected to be effective, foods that complement the effects of medicines, and foods that alleviate the side effects of medicines can be appropriately selected. Therefore, for patients suffering from lifestyle-related diseases, not only more appropriate herbal medicines but also more appropriate foodstuffs can be selected for recovery from lifestyle-related diseases.

In the program of this embodiment, like the device of this embodiment described above, the food is an excipient that is a part other than the crude drug base of a crude drug, and the food for patients is a tablet containing the crude drug. It is preferable. As a result, it is possible to obtain information such as the contraindications of excipients used in manufacturing tablets containing herbal medicines with the patient's medicine, so that appropriate excipients can be selected for tablets containing herbal medicines. It becomes possible to do so.

In the program and device of this embodiment, in the case of multifactorial diseases such as lifestyle-related diseases, it is becoming clear through genome analysis that the interaction between genetic predisposition and lifestyle factors (diet) causes the disease. In molecular biology, the field of nutrients and gene expression is rapidly progressing, and individual genetic differences are deeply involved in nutritional metabolism.In molecular physiology, we are elucidating the functions of enzymes, metabolism, etc., and agricultural science is being studied in omics. , nutritional science technology has been elucidated, and its products are linked to the elucidation of molecular genetics as a medical research through metaomics analysis such as genetic information transmission, protein synthesis and regulation, and based on evidence from that common discipline. Molecular nutrition is being elucidated as it is directly linked to medicine.

In the program of this embodiment, similarly to the apparatus of this embodiment described above, the crude drug/or food ingredient is a crude drug recognized as having evidence by molecular nutrition based on molecular biology, molecular genetics, and molecular physiology. / or a food ingredient is preferable. As crude drugs/foodstuffs are recognized as having evidence based on scientific methods, medical professionals such as doctors will be able to recommend appropriate crude drugs to patients suffering from lifestyle-related diseases to recover from lifestyle-related diseases. /or ingredients can be used.

Claims (12)

A device for selecting crude drugs for patients to be provided to patients suffering from lifestyle-related diseases,
medicine input means for inputting and storing the name of at least one patient medicine prescribed to the patient;
a crude drug input means for inputting and storing the name of the crude drug for patients ;
a first crude drug list storage unit for storing a drug in association with a crude drug that is contraindicated for combination with the drug;
The first crude drug list storage unit is searched based on the inputted medicine for sick people and the input herbal medicine for sick people, and it is determined that the herbal medicine for sick people and the medicine for sick people are contraindicated for combination. A compatible crude drug determination means for determining whether or not there is a compatible crude drug;
a result display means for displaying the determination result;
A device comprising: The device is
a second crude drug list storage unit for storing a drug in association with a crude drug that is expected to have a substitutive effect for the drug;
a third crude drug list storage unit for storing drugs in association with crude drugs that complement the effects of the drugs;
further comprising at least one storage unit selected from a fourth crude drug list storage unit for storing pharmaceuticals and crude drugs that alleviate side effects of the pharmaceuticals in association with each other;
The compatible herbal medicine determination means selects the second herbal medicine list storage unit, the third herbal medicine list storage unit, and/or the fourth herbal medicine list storage unit based on the inputted medicine for sick people and the inputted herbal medicine for sick people. The herbal medicine list storage unit is further searched to determine whether the herbal medicine for the sick person can be expected to have a substitute effect for the medicine for the sick person , whether or not it complements the effect of the medicine for the sick person, and/or whether the herbal medicine for the sick person can be expected to have a substitute effect for the medicine for the sick person , and/or 2. The device of claim 1, further configured to determine whether side effects of a medical drug for human use are alleviated. The herbal medicine for sick people is the herbal medicine for sick people to be blended or added to food for sick people,
The food for the sick has a food for the sick that is a part other than the crude drug base part,
food input means for inputting and storing the food for the sick ;
a first foodstuff list storage unit for storing medicines and foodstuffs that are contraindicated for the medicines in association with each other;
Based on the input medicine for the sick and the input food for the sick , the first food list storage unit is searched to determine whether the food for the sick and the medicine for the sick are contraindicated for combination. Compatible food determining means for determining whether or not there is a compatible food material,
further comprising;
The apparatus according to claim 1 or 2, wherein the result display means further displays the determination result of the compatible foodstuff determination means. The device is
a second foodstuff list storage unit for storing medicines and foodstuffs that are expected to have a substitute effect for the medicines in association with each other;
a third food list storage unit for storing medicines and food ingredients that complement the effects of the medicines in association with each other;
further comprising at least one storage unit selected from a fourth food list storage unit for storing medicines and food ingredients that alleviate the side effects of the medicines in association with each other;
The compatible foodstuff determining means selects the second foodstuff list storage section, the third foodstuffs list storage section, and/or the fourth foodstuff list storage section based on the inputted medicine for the sick and the inputted foodstuff for the sick. The food list storage unit is further searched to determine whether the food for the sick can be expected to have a substitute effect for the medicine for the sick , whether it complements the effect of the medicine for the sick, and/or whether the food for the sick can be expected to have a substitute effect for the medicine for the sick. 4. The device of claim 3, further configured to determine whether side effects of a medical drug for human use are alleviated. 5. The food for the sick according to claim 3 or 4, wherein the food for the sick is an excipient that is a part other than the crude drug base of the herbal medicine, and the food for the sick is a tablet containing the herbal medicine for the sick. Device. The herbal medicine for the sick and/or the food for the sick are based on molecular biology, molecular genetics, and molecular physiology, and the herbal medicine for the sick and/or the food for the disease that has been recognized as having evidence from molecular nutrition. The device according to any one of claims 1 to 5, which is a food product for people . A program for selecting crude drugs for patients suffering from lifestyle-related diseases using an information processing device, the program comprising:
The information processing device includes a first crude drug list storage unit for storing a drug and a crude drug that is contraindicated in combination with the drug in association with each other,
For the information processing device,
medicine input processing for inputting and storing the name of at least one patient medicine prescribed to the patient;
a crude drug input process for inputting and storing the name of the crude drug for patients ;
The first crude drug list storage unit is searched based on the inputted medicine for sick people and the input herbal medicine for sick people, and it is determined that the herbal medicine for sick people and the medicine for sick people are contraindicated for combination. Compatible crude drug determination processing for determining whether or not there is a compatible crude drug;
Result display processing for displaying the determination results;
A program to run. The information processing device
a second crude drug list storage unit for storing a drug in association with a crude drug that is expected to have a substitutive effect for the drug;
a third crude drug list storage unit for storing drugs in association with crude drugs that complement the effects of the drugs;
further comprising at least one storage unit selected from a fourth crude drug list storage unit for storing pharmaceuticals and crude drugs that alleviate side effects of the pharmaceuticals in association with each other;
Compatible crude drug determination process
The second herbal medicine list storage unit is searched based on the inputted medicine for the sick and the inputted herbal medicine for the sick , and the herbal medicine for the sick has a substitutive effect on the medicine for the sick. Determining whether or not it is the expected crude drug;
Searching the third herbal medicine list storage unit based on the inputted medicine and the inputted herbal medicine, and determining whether or not the herbal medicine for sick patients is a herbal medicine that complements the effect of the medicine for sick people . determining and/or
Searching the fourth herbal medicine list storage unit based on the inputted medicine and the inputted herbal medicine, and determining whether or not the herbal medicine for sick patients is a herbal medicine that alleviates the side effects of the medicine for sick people . The program according to claim 7, further comprising determining. The herbal medicine for sick people is the herbal medicine for sick people to be blended or added to food for sick people,
The food for the sick has a food for the sick that is a part other than the crude drug base part,
The information processing device further includes a first foodstuff list storage unit for storing pharmaceuticals and foodstuffs that are contraindicated for the pharmaceuticals in association with each other,
A program, for the information processing device,
food input processing for inputting and storing the food for the sick ;
Based on the input medicine for the sick and the input food for the sick , the first food list storage unit is searched to determine whether the food for the sick and the medicine for the sick are contraindicated for combination. A compatible food ingredient determination process to determine whether or not there is a
further execute
The program according to claim 7 or 8, wherein the result display process further displays the determination result of the compatible foodstuff determination process . The information processing device
a second foodstuff list storage unit for storing medicines and foodstuffs that are expected to have a substitute effect for the medicines in association with each other;
a third food list storage unit for storing medicines and food ingredients that complement the effects of the medicines in association with each other;
further comprising at least one storage unit selected from a fourth food list storage unit for storing medicines and food ingredients that alleviate the side effects of the medicines in association with each other;
The compatible foodstuff determination process includes :
The second food list storage unit is searched based on the inputted medicine for the sick and the inputted food for the sick , and the food for the sick has a substitutive effect for the medicine for the sick. Determining whether the food is the expected food or not;
The third food list storage unit is searched based on the input medicine for the sick and the input food for the sick , and the food for the sick complements the effect of the medicine for the sick. and/or
The fourth food list storage unit is searched based on the inputted medicine for the sick and the inputted food for the sick , and the food for the sick is a food that alleviates the side effects of the medicine for the sick. The program according to claim 9, further comprising determining whether or not. 11. The food for the sick according to claim 9 or 10, wherein the food for the sick is an excipient that is a part other than the crude drug base of the crude drug, and the food for the sick is a tablet containing the crude drug for the sick. program. The herbal medicine for the sick and/or the food for the sick are based on molecular biology, molecular genetics, and molecular physiology, and the herbal medicine for the sick and/or the food for the disease that has been recognized as having evidence from molecular nutrition. The program according to any one of claims 7 to 11, which is a food product for people .

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