JP7402525B2 - 電気外科用発生器 - Google Patents
電気外科用発生器 Download PDFInfo
- Publication number
- JP7402525B2 JP7402525B2 JP2020538809A JP2020538809A JP7402525B2 JP 7402525 B2 JP7402525 B2 JP 7402525B2 JP 2020538809 A JP2020538809 A JP 2020538809A JP 2020538809 A JP2020538809 A JP 2020538809A JP 7402525 B2 JP7402525 B2 JP 7402525B2
- Authority
- JP
- Japan
- Prior art keywords
- pulse
- microwave
- signal
- generator
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004520 electroporation Methods 0.000 claims description 74
- 239000000523 sample Substances 0.000 claims description 30
- 230000005855 radiation Effects 0.000 claims description 25
- 238000012384 transportation and delivery Methods 0.000 claims description 17
- 230000005540 biological transmission Effects 0.000 claims description 10
- 230000008878 coupling Effects 0.000 claims description 8
- 238000010168 coupling process Methods 0.000 claims description 8
- 238000005859 coupling reaction Methods 0.000 claims description 8
- 230000002427 irreversible effect Effects 0.000 claims description 8
- 230000002441 reversible effect Effects 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 30
- 238000011282 treatment Methods 0.000 description 20
- 239000004020 conductor Substances 0.000 description 16
- 238000010586 diagram Methods 0.000 description 13
- 238000005259 measurement Methods 0.000 description 12
- 238000002955 isolation Methods 0.000 description 11
- 238000002679 ablation Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 239000003989 dielectric material Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 235000014676 Phragmites communis Nutrition 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- 238000002357 laparoscopic surgery Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00589—Coagulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00601—Cutting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00702—Power or energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00761—Duration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1266—Generators therefor with DC current output
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/1273—Generators therefor including multiple generators in one device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B2018/128—Generators therefor generating two or more frequencies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1823—Generators therefor
Description
背景技術
図1は、本発明を理解するために有用である、GB 2 486 343に開示されているような電気外科用装置400の概略図を示す。この装置は、RFチャネル及びマイクロ波チャネルを含む。RFチャネルは、生体組織の治療(例えば、切断または乾燥)に適した電力レベルでRF周波数電磁信号を生成及び制御するためのコンポーネントを含む。マイクロ波チャネルは、生体組織の治療(例えば、凝固またはアブレーション)に適した電力レベルでマイクロ波周波数電磁信号を生成及び制御するためのコンポーネントを含む。
本発明は、上述の電気外科用発生器と統合することができるエレクトロポレーション波形供給ユニットを提供する。本明細書では、「エレクトロポレーション波形」という用語は、1つまたは複数の非常に短い高電圧エネルギーパルスを意味するために使用される。
(ii) 10kVで10nsパルス
(iii) 10kVで1nsパルス
アイソレータの物理構造は、1~100MHzの信号が完全に送信されるようにしたものになっている。300nsの矩形パルスの場合、周波数スペクトルにはメインローブがあり、最初のヌルは1/300GHz、または3.3MHzである。メインローブ及び周波数スペクトルの次の2つのサイドローブは、マルチプレクサの400kHz側、最大10MHzを通過する。35nsの立ち上がり時間は10MHzの帯域幅に対応すると予想されるため、この波形は実質的に妨げられずにアイソレータを通過する。
Claims (13)
- 電気外科用発生器であって、
無線周波数(RF)及びマイクロ波エネルギーを生成する電磁信号供給ユニットとを備え、前記電磁信号供給ユニットが、
第1の周波数を有するRF電磁(EM)放射を生成する無線周波数(RF)信号発生器と、
前記第1の周波数より高い第2の周波数を有するマイクロ波EM放射を生成するマイクロ波信号発生器とを含み、
前記RF及び前記マイクロ波エネルギーをその遠位端から送達するプローブに前記RF及び前記マイクロ波エネルギーを伝送する同軸伝送線に接続可能であるように構成された出力ポートと、
前記RF及び前記マイクロ波エネルギーを前記出力ポートへ伝達するフィード構造と、
生体組織の可逆的または不可逆的エレクトロポレーション(IRE)を引き起こすエレクトロポレーション波形を有するエネルギーを生成するように構成されたエレクトロポレーション波形供給ユニットとを含み
前記エレクトロポレーション波形供給ユニットは、
無線周波数(RF)及びマイクロ波エネルギーを生成する前記電磁信号供給ユニットとは別個のDC電源と、
前記DC電源に接続され、DC電力の1つ以上のパルスを前記エレクトロポレーション波形として出力するように構成されたパルス発生器と
を含み、
前記エレクトロポレーション波形供給ユニットが前記フィード構造に接続され、前記プローブへ送達するために、前記エレクトロポレーション波形を前記出力ポートに伝送し、
前記フィード構造が、前記エレクトロポレーション波形及び前記RF及びマイクロ波エネルギーを前記出力ポートに伝送するための共通の信号経路を含み、
前記フィード構造が、前記出力ポートを前記RF信号発生器に接続するRFチャネルと、前記出力ポートを前記マイクロ波信号発生器に接続するマイクロ波チャネルとを含み、
前記RFチャネル及び前記マイクロ波チャネルは、前記RF信号発生器と前記マイクロ波信号発生器から各々物理的に分離した信号経路を含み、
前記フィード構造は、前記RFチャネルから前記RF・EM放射を受信するように接続された第1の入力と、前記マイクロ波チャネルから前記マイクロ波EM放射を受信するように接続された第2の入力と、前記RF・EM放射と前記マイクロ波EM放射を前記共通の信号経路に送信するために前記第1の入力及び前記第2の入力と通信する出力とを有する結合回路を含む、
前記電気外科用発生器。 - 前記エレクトロポレーション波形供給ユニットが、前記RFチャネルを介して前記共通の信号経路に接続可能である、請求項1に記載の電気外科用発生器。
- 前記RFチャネルに接続されたスイッチを含み、
前記RF信号発生器及び前記エレクトロポレーション波形供給ユニットが、前記スイッチによって前記RFチャネルに選択的に接続可能である、請求項2に記載の電気外科用発生器。 - 前記マイクロ波チャネルを前記RF・EM放射から分離するように接続された導波管アイソレータを備える、請求項1~3のいずれか1項に記載の電気外科用発生器。
- 前記パルス発生器に接続され、前記パルス発生器に1つ以上のパルストリガ信号を送信するように構成されたパルス信号モジュールを含み、
前記パルス発生器は、パルストリガ信号を受信するとDC電力のパルスを出力するように構成される、請求項1~請求項4のいずれか1項に記載の電気外科用発生器。 - DC電力の各パルスの持続時間が、前記パルストリガ信号によって設定される、請求項5に記載の電気外科用発生器。
- 前記パルス信号モジュールが、DC電力の各パルスの前記持続時間の調整を可能にするように制御可能である、請求項6に記載の電気外科用発生器。
- DC電力の各パルスの前記持続時間が1ns~10msの範囲にある、請求項6または7に記載の電気外科用発生器。
- 前記DC電源が、
調整可能な電圧源と、
前記調整可能な電圧源の電圧をアップコンバートするためのDC-DCコンバータとを含み、
DC電力の各パルスの振幅が、前記調整可能な電圧源を介して制御可能である、請求項1~請求項8のいずれか1項に記載の電気外科用発生器。 - 前記パルス発生器がプッシュ・プル回路を備える、請求項1~請求項9のいずれか1項に記載の電気外科用発生器。
- DC電力の各パルスの最大振幅が10V~10kVの範囲にある、請求項9または10に記載の電気外科用発生器。
- DC電力の各パルスの前記最大振幅が400V以上である、請求項11に記載の電気外科用発生器。
- 前記エレクトロポレーション波形が、50%以下のデューティサイクルを有する複数のパルスを含む、請求項1~請求項12のいずれか1項に記載の電気外科用発生器。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1805124.3A GB2572400A (en) | 2018-03-29 | 2018-03-29 | Electrosurgical generator |
GB1805124.3 | 2018-03-29 | ||
PCT/EP2019/055914 WO2019185331A1 (en) | 2018-03-29 | 2019-03-08 | Electrosurgical generator |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021518770A JP2021518770A (ja) | 2021-08-05 |
JPWO2019185331A5 JPWO2019185331A5 (ja) | 2022-03-02 |
JP7402525B2 true JP7402525B2 (ja) | 2023-12-21 |
Family
ID=62142130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020538809A Active JP7402525B2 (ja) | 2018-03-29 | 2019-03-08 | 電気外科用発生器 |
Country Status (14)
Country | Link |
---|---|
US (1) | US11717336B2 (ja) |
EP (1) | EP3773288B1 (ja) |
JP (1) | JP7402525B2 (ja) |
KR (1) | KR20200136881A (ja) |
CN (1) | CN111629680B (ja) |
AU (1) | AU2019245726A1 (ja) |
BR (1) | BR112020014008A2 (ja) |
CA (1) | CA3088331A1 (ja) |
ES (1) | ES2906407T3 (ja) |
GB (1) | GB2572400A (ja) |
IL (1) | IL275882A (ja) |
PT (1) | PT3773288T (ja) |
SG (1) | SG11202006724PA (ja) |
WO (1) | WO2019185331A1 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2588070B (en) * | 2019-04-29 | 2022-11-16 | Creo Medical Ltd | Electrosurgical system |
GB2589604A (en) | 2019-12-04 | 2021-06-09 | Creo Medical Ltd | Pulse generating circuit, and electrosurgical generator incorporating the same |
GB2589605A (en) | 2019-12-04 | 2021-06-09 | Creo Medical Ltd | Pule generating circuit, and electrosurgical generator incorporating the same |
US11903638B2 (en) | 2019-12-11 | 2024-02-20 | Biosense Webster (Israel) Ltd. | Regulating delivery of irreversible electroporation pulses according to transferred energy |
GB2590924A (en) * | 2020-01-06 | 2021-07-14 | Creo Medical Ltd | A receiver for wirelessly receiving power from a transmitter, a capsule for ingestion by a patient, and a wireless power transfer system |
CN112336448B (zh) * | 2020-11-05 | 2021-12-28 | 上海倍可达医疗科技有限公司 | 不可逆电穿孔电路、心脏不可逆电穿孔装置 |
CA3214189A1 (en) | 2021-04-07 | 2022-10-13 | Vojtech NEDVED | Pulsed field ablation device and method |
IL309432A (en) | 2021-07-06 | 2024-02-01 | Btl Medical Dev A S | Apparatus and method for ablation (burning) by electric pulse field |
CN115005961B (zh) * | 2022-07-07 | 2023-05-12 | 上海普实医疗器械股份有限公司 | 心脏脉冲电场消融系统 |
CN117045962B (zh) * | 2023-10-11 | 2024-01-30 | 泉州艾奇科技有限公司 | 微电射频控制电路及美容仪 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009504346A (ja) | 2005-08-19 | 2009-02-05 | オールド ドミニオン リサーチ ファウンデーション | 組織内での動作のための超広帯域アンテナ |
WO2010068795A2 (en) | 2008-12-12 | 2010-06-17 | Pearson Robert M | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
US20150105701A1 (en) | 2013-08-22 | 2015-04-16 | Energize Medical Llc | Therapeutic energy systems |
JP2016538962A (ja) | 2013-12-09 | 2016-12-15 | クレオ・メディカル・リミテッドCreo Medical Limited | 生体組織に供給するために無線周波数エネルギーおよびマイクロ波エネルギーを生成するための電気手術装置 |
US20170333109A1 (en) | 2016-05-23 | 2017-11-23 | Covidien Lp | System and method for temperature enhanced irreversible electroporation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6246905B1 (en) * | 1999-07-30 | 2001-06-12 | Jamil Ahmad Mogul | Medical instrument that supplies multiple energy forms |
CA2497649A1 (en) * | 2002-09-30 | 2004-04-15 | Maxcyte, Inc. | Apparatus and method for streaming electroporation |
SG123643A1 (en) * | 2004-12-28 | 2006-07-26 | Nanyan Polytechnic | Programmable apparatus and method for optimizing and real time monitoring of gene transfection basedon user configured arbitrary waveform pulsing tra in |
ITTO20070044A1 (it) * | 2007-01-23 | 2008-07-24 | Igea Srl | Dispositivo per la generazione di impulsi di tensione controllabili mediante dispositivi interruttori allo stato solido ed applicabili al corpo umano |
US10639098B2 (en) * | 2014-05-06 | 2020-05-05 | Cosman Instruments, Llc | Electrosurgical generator |
US20170189095A1 (en) * | 2015-12-31 | 2017-07-06 | Ethicon Endo-Surgery, Llc | Multiple port electrical isolation technique for surgical instruments |
US10575892B2 (en) * | 2015-12-31 | 2020-03-03 | Ethicon Llc | Adapter for electrical surgical instruments |
EP3476032B1 (en) * | 2016-06-26 | 2021-08-04 | The Board of Trustees of the Leland Stanford Junior University | Bipolar dc-dc converter topology using passive voltage reversal |
-
2018
- 2018-03-29 GB GB1805124.3A patent/GB2572400A/en not_active Withdrawn
-
2019
- 2019-03-08 KR KR1020207019478A patent/KR20200136881A/ko not_active Application Discontinuation
- 2019-03-08 BR BR112020014008-2A patent/BR112020014008A2/pt not_active IP Right Cessation
- 2019-03-08 ES ES19709491T patent/ES2906407T3/es active Active
- 2019-03-08 SG SG11202006724PA patent/SG11202006724PA/en unknown
- 2019-03-08 WO PCT/EP2019/055914 patent/WO2019185331A1/en active Application Filing
- 2019-03-08 EP EP19709491.5A patent/EP3773288B1/en active Active
- 2019-03-08 JP JP2020538809A patent/JP7402525B2/ja active Active
- 2019-03-08 AU AU2019245726A patent/AU2019245726A1/en active Pending
- 2019-03-08 CA CA3088331A patent/CA3088331A1/en active Pending
- 2019-03-08 US US16/961,149 patent/US11717336B2/en active Active
- 2019-03-08 PT PT197094915T patent/PT3773288T/pt unknown
- 2019-03-08 CN CN201980008800.9A patent/CN111629680B/zh active Active
-
2020
- 2020-07-06 IL IL275882A patent/IL275882A/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009504346A (ja) | 2005-08-19 | 2009-02-05 | オールド ドミニオン リサーチ ファウンデーション | 組織内での動作のための超広帯域アンテナ |
WO2010068795A2 (en) | 2008-12-12 | 2010-06-17 | Pearson Robert M | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
US20150105701A1 (en) | 2013-08-22 | 2015-04-16 | Energize Medical Llc | Therapeutic energy systems |
JP2016538962A (ja) | 2013-12-09 | 2016-12-15 | クレオ・メディカル・リミテッドCreo Medical Limited | 生体組織に供給するために無線周波数エネルギーおよびマイクロ波エネルギーを生成するための電気手術装置 |
US20170333109A1 (en) | 2016-05-23 | 2017-11-23 | Covidien Lp | System and method for temperature enhanced irreversible electroporation |
Also Published As
Publication number | Publication date |
---|---|
US11717336B2 (en) | 2023-08-08 |
IL275882A (en) | 2020-08-31 |
EP3773288A1 (en) | 2021-02-17 |
CN111629680B (zh) | 2023-03-28 |
JP2021518770A (ja) | 2021-08-05 |
WO2019185331A1 (en) | 2019-10-03 |
SG11202006724PA (en) | 2020-08-28 |
KR20200136881A (ko) | 2020-12-08 |
RU2020123242A (ru) | 2022-04-29 |
GB2572400A (en) | 2019-10-02 |
PT3773288T (pt) | 2022-02-17 |
ES2906407T3 (es) | 2022-04-18 |
BR112020014008A2 (pt) | 2020-12-01 |
RU2020123242A3 (ja) | 2022-04-29 |
AU2019245726A1 (en) | 2020-07-23 |
EP3773288B1 (en) | 2022-01-19 |
GB2572400A8 (en) | 2019-10-09 |
GB201805124D0 (en) | 2018-05-16 |
CA3088331A1 (en) | 2020-07-13 |
CN111629680A (zh) | 2020-09-04 |
US20200397497A1 (en) | 2020-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7402525B2 (ja) | 電気外科用発生器 | |
JP6774068B2 (ja) | 電気外科装置 | |
DK3079619T3 (en) | ELECTRO-SURGICAL DEVICE FOR GENERATION OF RADIO FREQUENCY ENERGY AND MICROWAVE ENERGY FOR DELIVERY TO BIOLOGICAL Tissue | |
KR102354441B1 (ko) | 무선 주파수 에너지 및 마이크로파 에너지를 전달하기 위한 전기 수술 장치 및 이의 사용 방법 | |
GB2521611A (en) | Electrosurgical apparatus and electrosurgical device | |
EP4084712B1 (en) | Electrosurgical generator for delivering microwave energy at multiple frequencies | |
RU2777944C2 (ru) | Электрохирургический генератор энергии для электроимпульсного открытия клеточных пор | |
EP4190261A1 (en) | Microwave amplification apparatus for an electrosurgical instrument |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A529 | Written submission of copy of amendment under article 34 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A529 Effective date: 20200713 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220221 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220221 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20230120 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230221 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230410 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20230704 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230915 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20231010 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20231107 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20231204 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7402525 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |