JP7399880B2 - ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体 - Google Patents

ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体 Download PDF

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JP7399880B2
JP7399880B2 JP2020561607A JP2020561607A JP7399880B2 JP 7399880 B2 JP7399880 B2 JP 7399880B2 JP 2020561607 A JP2020561607 A JP 2020561607A JP 2020561607 A JP2020561607 A JP 2020561607A JP 7399880 B2 JP7399880 B2 JP 7399880B2
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amino acid
acid position
domain
binding polypeptide
tyrosine
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JP2021511830A5 (https=
JPWO2019147973A5 (https=
JP2021511830A (ja
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ホワウェイ・チウ
ブライアン・マクネス
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Genzyme Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020561607A 2018-01-26 2019-01-25 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体 Active JP7399880B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023204313A JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2025179195A JP2026021377A (ja) 2018-01-26 2025-10-24 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862622468P 2018-01-26 2018-01-26
US62/622,468 2018-01-26
PCT/US2019/015204 WO2019147973A1 (en) 2018-01-26 2019-01-25 Fc variants with enhanced binding to fcrn and prolonged half-life

Related Child Applications (1)

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JP2023204313A Division JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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JP2021511830A JP2021511830A (ja) 2021-05-13
JP2021511830A5 JP2021511830A5 (https=) 2022-02-01
JPWO2019147973A5 JPWO2019147973A5 (https=) 2022-02-01
JP7399880B2 true JP7399880B2 (ja) 2023-12-18

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JP2020561607A Active JP7399880B2 (ja) 2018-01-26 2019-01-25 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2023204313A Pending JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2025179195A Pending JP2026021377A (ja) 2018-01-26 2025-10-24 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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JP2023204313A Pending JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2025179195A Pending JP2026021377A (ja) 2018-01-26 2025-10-24 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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US (1) US20190263934A1 (https=)
EP (1) EP3743441A1 (https=)
JP (3) JP7399880B2 (https=)
KR (2) KR102748986B1 (https=)
CN (2) CN111788221B (https=)
AU (2) AU2019212638B2 (https=)
BR (1) BR112020015006A2 (https=)
CA (1) CA3089602A1 (https=)
CO (1) CO2020010269A2 (https=)
IL (2) IL318916A (https=)
MX (2) MX2020007882A (https=)
MY (1) MY203898A (https=)
PH (1) PH12020551134A1 (https=)
SG (1) SG11202006905YA (https=)
TW (1) TW201940512A (https=)
WO (1) WO2019147973A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022542884A (ja) * 2019-07-25 2022-10-07 ジェンザイム・コーポレーション Ｆｃｒｎアンタゴニストで抗体媒介性障害を処置する方法
JP2024026255A (ja) * 2018-01-26 2024-02-28 ジェンザイム・コーポレーション ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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CN114746120B (zh) 2019-10-03 2024-07-30 Atyr医药公司 包含抗nrp2抗体的组合物和方法
US11434276B2 (en) * 2020-05-11 2022-09-06 Invetx, Inc. Polypeptides with altered binding to neonatal Fc receptor (FcRn) and methods of use
MX2023004933A (es) * 2020-10-29 2023-06-06 Formycon Ag Proteinas de fusion de ace2 y usos de las mismas.
US12297273B2 (en) 2021-05-27 2025-05-13 Sanofi Fc variant with enhanced affinity to Fc receptors and improved thermal stability
MX2024002150A (es) 2021-08-20 2024-03-08 Intervet Int Bv Anticuerpos y proteinas de fusion de igg con una semivida prolongada.
WO2023244276A2 (en) * 2021-10-13 2023-12-21 The Wistar Institute Of Anatomy And Biology DNA ENCODED ANTIBODIES WITH Fc MODIFICATIONS
IL317227A (en) 2022-05-27 2025-01-01 Sanofi Sa Combined natural killer (NK) cells bind to NKP46 and BCMA variants with FC engineering
CN116162171B (zh) * 2022-10-13 2025-06-03 深圳市百士通科技开发有限公司 抗体突变方法在治疗性抗体药物中的应用
KR20250094703A (ko) 2022-10-25 2025-06-25 아블린쓰 엔.브이. 향상된 효과기 기능을 갖는 당조작된 Fc 변이체 폴리펩타이드
AR131281A1 (es) 2022-12-05 2025-03-05 Sanofi Sa Proteínas de unión al receptor de transferrina
US20250154262A1 (en) 2023-10-25 2025-05-15 Ablynx N.V. Fc DOMAIN VARIANTS WITH ENHANCED Fc RECEPTOR BINDING
WO2025101094A1 (en) * 2023-11-08 2025-05-15 Ооо «Geropharm» Fc fragment polypeptide for producing therapeutically active fusion polypeptides and conjugates
WO2025149633A1 (en) 2024-01-12 2025-07-17 Laigo Bio B.V. Bispecific antigen binding proteins
WO2026022712A1 (en) 2024-07-23 2026-01-29 Sanofi Cereblon ligase modulator and bcma nk cell engager combination therapy

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JP2008519860A (ja) 2004-11-12 2008-06-12 ゼンコー・インコーポレイテッド ＦｃＲｎとの変化した結合を有するＦｃ変異体
JP2011502126A (ja) 2007-10-31 2011-01-20 ゼンコア インコーポレイテッド ＦｃＲｎへの変異結合を有するＦｃ変異体
WO2013047748A1 (ja) 2011-09-30 2013-04-04 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
JP2017534646A (ja) 2014-11-10 2017-11-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ｉｌ−１ベータ抗体及び使用方法

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JP2008519860A (ja) 2004-11-12 2008-06-12 ゼンコー・インコーポレイテッド ＦｃＲｎとの変化した結合を有するＦｃ変異体
WO2006130834A2 (en) 2005-05-31 2006-12-07 Board Of Regents, The University Of Texas System IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF
JP2011502126A (ja) 2007-10-31 2011-01-20 ゼンコア インコーポレイテッド ＦｃＲｎへの変異結合を有するＦｃ変異体
WO2013047748A1 (ja) 2011-09-30 2013-04-04 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
JP2017534646A (ja) 2014-11-10 2017-11-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ｉｌ−１ベータ抗体及び使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024026255A (ja) * 2018-01-26 2024-02-28 ジェンザイム・コーポレーション ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2022542884A (ja) * 2019-07-25 2022-10-07 ジェンザイム・コーポレーション Ｆｃｒｎアンタゴニストで抗体媒介性障害を処置する方法

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Publication number Publication date
MY203898A (en) 2024-07-23
KR20250008975A (ko) 2025-01-16
EP3743441A1 (en) 2020-12-02
BR112020015006A2 (pt) 2020-12-29
KR102748986B1 (ko) 2025-01-02
AU2019212638A1 (en) 2020-09-17
CN111788221A (zh) 2020-10-16
MX2020007882A (es) 2020-12-03
IL276286A (en) 2020-09-30
US20190263934A1 (en) 2019-08-29
NZ767453A (en) 2025-03-28
CO2020010269A2 (es) 2020-12-10
JP2026021377A (ja) 2026-02-10
IL276286B1 (en) 2025-03-01
RU2020128177A (ru) 2022-02-28
SG11202006905YA (en) 2020-08-28
CN119350481A (zh) 2025-01-24
TW201940512A (zh) 2019-10-16
MX2025009543A (es) 2025-09-02
KR20200115568A (ko) 2020-10-07
IL318916A (en) 2025-04-01
JP2021511830A (ja) 2021-05-13
CN111788221B (zh) 2026-02-13
AU2019212638B2 (en) 2025-04-03
CA3089602A1 (en) 2019-08-01
PH12020551134A1 (en) 2021-05-31
IL276286B2 (en) 2025-07-01
AU2025204826A1 (en) 2025-07-17
JP2024026255A (ja) 2024-02-28
WO2019147973A1 (en) 2019-08-01

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