JP7399880B2 - ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体 - Google Patents

ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体 Download PDF

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JP7399880B2
JP7399880B2 JP2020561607A JP2020561607A JP7399880B2 JP 7399880 B2 JP7399880 B2 JP 7399880B2 JP 2020561607 A JP2020561607 A JP 2020561607A JP 2020561607 A JP2020561607 A JP 2020561607A JP 7399880 B2 JP7399880 B2 JP 7399880B2
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amino acid
acid position
domain
binding polypeptide
tyrosine
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JP2021511830A5 (https=
JP2021511830A (ja
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ホワウェイ・チウ
ブライアン・マクネス
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Genzyme Corp
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Genzyme Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2020561607A 2018-01-26 2019-01-25 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体 Active JP7399880B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023204313A JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2025179195A JP2026021377A (ja) 2018-01-26 2025-10-24 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862622468P 2018-01-26 2018-01-26
US62/622,468 2018-01-26
PCT/US2019/015204 WO2019147973A1 (en) 2018-01-26 2019-01-25 Fc variants with enhanced binding to fcrn and prolonged half-life

Related Child Applications (1)

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JP2023204313A Division JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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JP2021511830A JP2021511830A (ja) 2021-05-13
JP2021511830A5 JP2021511830A5 (https=) 2022-02-01
JP7399880B2 true JP7399880B2 (ja) 2023-12-18

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JP2020561607A Active JP7399880B2 (ja) 2018-01-26 2019-01-25 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2023204313A Pending JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2025179195A Pending JP2026021377A (ja) 2018-01-26 2025-10-24 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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JP2023204313A Pending JP2024026255A (ja) 2018-01-26 2023-12-04 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2025179195A Pending JP2026021377A (ja) 2018-01-26 2025-10-24 ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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US (1) US20190263934A1 (https=)
EP (1) EP3743441A1 (https=)
JP (3) JP7399880B2 (https=)
KR (2) KR20250008975A (https=)
CN (2) CN111788221B (https=)
AU (2) AU2019212638B2 (https=)
BR (1) BR112020015006A2 (https=)
CA (1) CA3089602A1 (https=)
CO (1) CO2020010269A2 (https=)
IL (2) IL276286B2 (https=)
MX (2) MX2020007882A (https=)
MY (1) MY203898A (https=)
PH (1) PH12020551134A1 (https=)
SG (1) SG11202006905YA (https=)
TW (1) TW201940512A (https=)
WO (1) WO2019147973A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022542884A (ja) * 2019-07-25 2022-10-07 ジェンザイム・コーポレーション Ｆｃｒｎアンタゴニストで抗体媒介性障害を処置する方法
JP2024026255A (ja) * 2018-01-26 2024-02-28 ジェンザイム・コーポレーション ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体

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CA3156803A1 (en) 2019-10-03 2021-04-08 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
CN120590527A (zh) * 2020-05-11 2025-09-05 因外泰克斯公司 用于增加治疗剂在犬中的半衰期的组合物和使用方法
KR20230093483A (ko) * 2020-10-29 2023-06-27 포르미콘 아게 Ace2 융합 단백질 및 이의 용도
EP4347640A1 (en) 2021-05-27 2024-04-10 Sanofi Fc variant with enhanced affinity to fc receptors and improved thermal stability
AU2022329459A1 (en) 2021-08-20 2024-02-29 Intervet International B.V. Antibodies and igg fusion proteins with an extended half-life
WO2023064841A1 (en) * 2021-10-13 2023-04-20 The Wistar Institute Of Anatomy And Biology Antibodies for use against sars-cov-2
KR20250017240A (ko) 2022-05-27 2025-02-04 사노피 FC-조작을 갖는 NKp46 및 BCMA 변이체에 결합하는 자연 살해(NK) 세포 관여자
CN116162171B (zh) * 2022-10-13 2025-06-03 深圳市百士通科技开发有限公司 抗体突变方法在治疗性抗体药物中的应用
WO2024089609A1 (en) 2022-10-25 2024-05-02 Ablynx N.V. Glycoengineered fc variant polypeptides with enhanced effector function
EP4630455A1 (en) 2022-12-05 2025-10-15 Sanofi Transferrin receptor binding proteins
TW202535925A (zh) 2023-10-25 2025-09-16 比利時商艾伯霖克斯公司 具有增強的Ｆｃ受體結合之Ｆｃ結構域變體
WO2025101094A1 (en) * 2023-11-08 2025-05-15 Ооо «Geropharm» Fc fragment polypeptide for producing therapeutically active fusion polypeptides and conjugates
WO2025149633A1 (en) 2024-01-12 2025-07-17 Laigo Bio B.V. Bispecific antigen binding proteins
WO2026022712A1 (en) 2024-07-23 2026-01-29 Sanofi Cereblon ligase modulator and bcma nk cell engager combination therapy

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JP2008519860A (ja) 2004-11-12 2008-06-12 ゼンコー・インコーポレイテッド ＦｃＲｎとの変化した結合を有するＦｃ変異体
JP2011502126A (ja) 2007-10-31 2011-01-20 ゼンコア インコーポレイテッド ＦｃＲｎへの変異結合を有するＦｃ変異体
WO2013047748A1 (ja) 2011-09-30 2013-04-04 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
JP2017534646A (ja) 2014-11-10 2017-11-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ｉｌ−１ベータ抗体及び使用方法

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JP2008519860A (ja) 2004-11-12 2008-06-12 ゼンコー・インコーポレイテッド ＦｃＲｎとの変化した結合を有するＦｃ変異体
WO2006130834A2 (en) 2005-05-31 2006-12-07 Board Of Regents, The University Of Texas System IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF
JP2011502126A (ja) 2007-10-31 2011-01-20 ゼンコア インコーポレイテッド ＦｃＲｎへの変異結合を有するＦｃ変異体
WO2013047748A1 (ja) 2011-09-30 2013-04-04 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
JP2017534646A (ja) 2014-11-10 2017-11-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ｉｌ−１ベータ抗体及び使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024026255A (ja) * 2018-01-26 2024-02-28 ジェンザイム・コーポレーション ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体
JP2022542884A (ja) * 2019-07-25 2022-10-07 ジェンザイム・コーポレーション Ｆｃｒｎアンタゴニストで抗体媒介性障害を処置する方法

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Publication number Publication date
MY203898A (en) 2024-07-23
RU2020128177A (ru) 2022-02-28
TW201940512A (zh) 2019-10-16
IL276286B1 (en) 2025-03-01
CA3089602A1 (en) 2019-08-01
AU2019212638B2 (en) 2025-04-03
KR102748986B1 (ko) 2025-01-02
AU2019212638A1 (en) 2020-09-17
IL318916A (en) 2025-04-01
EP3743441A1 (en) 2020-12-02
KR20200115568A (ko) 2020-10-07
CN119350481A (zh) 2025-01-24
BR112020015006A2 (pt) 2020-12-29
CN111788221B (zh) 2026-02-13
CO2020010269A2 (es) 2020-12-10
KR20250008975A (ko) 2025-01-16
MX2025009543A (es) 2025-09-02
MX2020007882A (es) 2020-12-03
CN111788221A (zh) 2020-10-16
WO2019147973A1 (en) 2019-08-01
PH12020551134A1 (en) 2021-05-31
AU2025204826A1 (en) 2025-07-17
US20190263934A1 (en) 2019-08-29
JP2026021377A (ja) 2026-02-10
JP2021511830A (ja) 2021-05-13
JP2024026255A (ja) 2024-02-28
IL276286B2 (en) 2025-07-01
NZ767453A (en) 2025-03-28
SG11202006905YA (en) 2020-08-28
IL276286A (en) 2020-09-30

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