JP7303969B2 - Liquid composition for electronic cigarette and electronic cigarette having the same - Google Patents

Description

TECHNICAL FIELD The present invention relates to a liquid composition for electronic cigarette containing at least cannabinoid and caffeine and an electronic cigarette having the same.

Hemp, a plant, is also called cannabis, cannabis, etc., and its leaves and flowers in particular contain tetrahydrocannabinol (THC), which has a unique effect on humans. Or dried flowers are sometimes called 'taima' again, and have been used for a long time.

Patent Literature 1 describes a “TRP channel blocker” containing the cannabinoids “a combination of cannabidiol (CBD) and tetrahydrocannabinol (THC)”, which blocks neuropathic pain and inflammation. , vasoconstriction, etc. are alleviated, and furthermore, it is stated that these two cannabinoids are extracted (produced) from cannabis.
However, this "TRP channel blocker" contains tetrahydrocannabinol (THC) as an essential component, and the blockade of TRP channels has also been confirmed in petri dishes and administered via the human respiratory tract. In addition, there is no description to the effect that the above-mentioned symptoms were alleviated, and it was not directly confirmed in humans.

Patent Literature 2 describes a health food containing CBD oil and fucoidan, and the combination of them exhibits a synergistic effect, and states that the cells of the human body can be normalized and activated.
However, in addition to the fact that "CBD oil" contains tetrahydrocannabinol (THC), which is generally regarded as dangerous, Patent Document 2 does not describe that administration is from the respiratory tract, and e-cigarettes There is no mention or suggestion of

Patent Document 3 describes an extract containing cannabinoids and terpenes/flavonoids, wherein the "cannabinoids" include at least four cannabinoids.
However, the invention described in Patent Document 3 is characterized by the extraction method and the content ratio of the above four types, and among the four types, tetrahydrocannabinol (THC), which is generally considered dangerous, exists as an option. and the administration was via juice or smoothie.

Patent Document 4 describes a composition containing cannabinoids, a propellant, alcohol, etc., and also describes pulmonary administration of the composition in the form of an aerosol containing fine particles.
However, the composition of Patent Literature 4 has tetrahydrocannabinol (THC) as an option, and is useful for neuropathic pain, motion sickness, arthritis, Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc. The present invention provides a method for treating subjects suffering from or having a disability such as "neurodegenerative disease", which provides both arousal and sedative effects to humans, particularly healthy individuals. It was nothing.

On the other hand, caffeine has long been widely known as a beverage containing caffeine as a stimulating effect on humans.
The invention described in Patent Document 5 is an invention relating to a release device that "processes the flow of vaporized liquid" of an electronic cigarette, and it is described that the electronic cigarette can ingest anti-aging compounds into the body. And caffeine is given as an example of about 80 kinds of anti-aging compounds listed (enumerated).
However, Patent Document 5 does not describe any synergistic effect with cannabinoids, nor does it describe the awakening effect in humans by inhaling caffeine into the lungs, or the compatibility between the awakening effect and the sedative effect.

On the other hand, the liquid composition for electronic cigarettes, that is, the substances and components that are atomized and inhaled by electronic cigarettes include hot spring ingredients, Chinese herbal medicine ingredients, herbal ingredients, aroma oils (essential oils), vitamins and minerals, and amino acids. Ingredients and the like are the main components (for example, Patent Document 6), and none of them contain components like the present invention, nor do they exhibit (expect) the additive effects of the present invention.

In recent years, while the number of mental workers has increased and an awake state is desired, there is also a desire for a calm state in which sufficient sleep can be obtained due to increased stress. None of the e-cigarettes were used for applications that could achieve both arousal and sedative effects.

In addition, many people want to quit smoking in order to break their addiction to nicotine-containing cigarettes. Tobacco dependence includes physical dependence (nicotine dependence) and psychological dependence (behavioral dependence). Of these, psychological dependence is due to habits and quirks, and tends to become stronger as the duration of smoking increases. Most of the conventional nicotine-free electronic cigarettes focus medically on breaking away from nicotine dependence, and almost none focus on the psychological dependence (behavioral dependence).

WO2008/129258 JP 2017-079615 A WO2016/064987 JP 2018-150334 A WO2017/046363 JP 2012-005412 A

The present invention has been made in view of the above-mentioned background art, and its object is to solve the above-mentioned problems, and to provide a device (instrument) that has an awakening effect and a sedative effect when ingested into the human body, and , to provide a liquid composition for such devices.

In order to solve the above problems, as a result of extensive studies, the present inventors adopted an electronic cigarette as the device and ingested into the body from the respiratory tract, and furthermore, a liquid composition for the electronic cigarette ( The present inventors have completed the present invention by discovering that both a stimulant effect and a sedative effect can be achieved by containing at least both cannabinoids and caffeine as a liquid for electronic cigarettes.

That is, the present invention provides a liquid composition for electronic cigarettes that releases an active ingredient contained in the liquid composition by heating the liquid composition,
Provided is a liquid composition for electronic cigarettes, characterized by containing at least "a cannabinoid contained in hemp stems or seeds", caffeine, and a solvent.

The present invention also provides cannabinoids extracted from hemp stalks or seeds, cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabielsoin (CBE), and cannabigerol (CBG). ), and at least one cannabinoid selected from the group consisting of cannabidivarin (CBDV).

The present invention also provides the liquid composition for electronic cigarettes, wherein the cannabinoid dissolved in the liquid composition for electronic cigarettes is derived from crystals of cannabidiol (CBD) extracted from hemp stems or seeds. It provides

Further, the present invention provides the liquid composition for an electronic cigarette, which contains 1 part by mass or more and 300 parts by mass or less of the cannabinoid and 0.01 part by mass or more and 10 parts by mass or less of the caffeine with respect to 100 parts by mass of the solvent. It provides things.

The present invention also provides an electronic cigarette comprising the liquid composition for an electronic cigarette.

According to the present invention, the above problems and the above problems are solved, and cannabinoids and caffeine are released by evaporation or atomization using a heated electronic cigarette, and by inhaling them into the lungs, They can bring about a stimulating effect and a sedative effect at the same time to humans who ingest them. That is, according to the present invention, it is possible to achieve both an awakening effect and a sedative effect.
Specifically, in particular, immediately after ingestion, the "computation speed" is remarkably increased, an awakening effect such as being effective in waking up the next day (waking up well, etc.) is obtained, and going to bed or sleeping on the day of ingestion A calming effect can be obtained that is said to be effective for (e.g., falling asleep better).

Normally, it is desirable to be awake during the day due to work or the like, but it is also desirable to have sufficient sleep in order to remove the stress and the like received during the day. According to the present invention, for example, an awakening effect during work and a calming effect due to sleep, for example, can be obtained at the same time.

Further, according to the present invention, since "smoking with nicotine" can be substituted, it is possible to get rid of nicotine dependence while making use of psychological dependence (behavioral dependence) on smoking.

Furthermore, the cannabinoids, caffeine, and preferably the solvent, which are the essential components of the liquid composition for electronic cigarettes of the present invention, are all plant-derived, so that they can be used with peace of mind. effect is also increased.
Moreover, by not including tetrahydrocannabinol (THC) in the liquid composition for electronic cigarettes of the present invention, it is medically and legally acceptable, and the effect of the invention is excellent.

Further, by setting the concentrations (proportions) of the cannabinoids and caffeine in the liquid composition for electronic cigarettes of the present invention and the content ratio of the two within a specific range, the above effects can be more favorably exhibited.

The present invention will be described below, but the present invention is not limited to the following specific forms, and can be arbitrarily modified within the scope of the technical idea.

The liquid composition for electronic cigarettes of the present invention is a liquid composition for electronic cigarettes that releases an active ingredient contained in the liquid composition by heating the liquid composition, and is contained in hemp stems or seeds. It is characterized by containing at least cannabinoids, caffeine, and a solvent.

<E-cigarette>
The electronic cigarette in the present invention may be any one that releases the active ingredient contained in the liquid composition by heating the liquid composition, such as commercially available electronic cigarettes and heat-not-burn cigarettes. Those having the system/structure used are also preferably used. The release is not particularly limited, and includes atomization, vaporization by evaporation/sublimation, release in the form of an aerosol, and the like.

A battery is preferably used as the heating source, and any wire such as kanthal, nichrome, stainless steel, nickel, or titanium can be used. Also, a vaporizer may be used.
The liquid composition for electronic cigarettes of the present invention may be put directly into an electronic cigarette, may be in a cartridge system, or may be used by impregnating absorbent cotton, a non-woven fabric, or the like.

The present invention also provides an electronic cigarette characterized by having the following liquid composition for electronic cigarettes.

<Cannabinoids>
“Cannabinoids” is a general term for chemical substances contained in hemp (cannabis plant).
The cannabinoid contained in the liquid composition for electronic cigarettes of the present invention may be extracted from hemp (cannabis plant), synthesized, or semi-synthesized by reacting the extracted material. may be
The concept of "extracted from hemp" includes (can use) one cannabinoid, can also include (can use) mixtures of multiple (dozens of) cannabinoids, and does not include (semi-)synthetic , cannabinoid derivatives and their salts are also included (can be used).

The cannabinoid in the present invention is preferably extracted from hemp (cannabis plant). Since hemp leaves or flowers extracted from hemp contain tetrahydrocannabinol (THC), which is legally regulated in some countries, the cannabinoid in the present invention does not contain tetrahydrocannabinol (THC). More preferred are those extracted from hemp stems or seeds.
According to the Cannabis Control Law of Japan, the above-mentioned "hemp stalks or seeds" are not included in "mature hemp stalks or seeds" because they do not contain tetrahydrocannabinol (THC) at all. are particularly preferred.

Containing tetrahydrocannabinol (THC) is legally regulated and may cause phenomena, symptoms, and effects that cannot be said to be desirable stimulant effects or sedative effects. It may not be suitable. In other words, the liquid composition for electronic cigarettes of the present invention preferably does not contain tetrahydrocannabinol (THC).

The liquid composition for electronic cigarettes of the present invention includes cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabinol (CBE), and the above cannabinoids extracted from hemp stems or seeds. It preferably contains at least one cannabinoid selected from the group consisting of cannabigerol (CBG) and cannabidivarin (CBDV).
The above cannabinoids may contain one type or two or more types.

<<Cannabidiol (CBD)>>
Among them, it is more preferable to contain cannabidiol (CBD) as a main component of cannabinoids. Here, the "main component" means that one kind of cannabinoid is contained in an amount of 80% by mass or more relative to the total cannabinoids, more preferably 90% by mass or more, and 97% by mass or more. It is more preferable to

Furthermore, in the liquid composition for electronic cigarettes of the present invention, cannabidiol (CBD) can be contained in an amount of 100% by mass based on the total cannabinoids, that is, only cannabidiol (CBD) can be used as the "cannabinoid". Particularly preferred is a liquid composition for electronic cigarettes in which crystals of cannabidiol (CBD) extracted from hemp stems or seeds are dissolved in a solvent to be described later.
That is, in the liquid composition for electronic cigarettes of the present invention, the cannabinoid dissolved in the liquid composition for electronic cigarettes is derived from cannabidiol (CBD) crystals extracted from hemp stems or seeds. is most preferred.

<Caffeine>
The caffeine contained in the liquid composition for electronic cigarettes of the present invention may be so-called "pure caffeine" or may not be "pure caffeine", but it is contained in a plant and extracted from the plant. It is easy to produce and is naturally derived, which is preferable because "all of the components contained in the liquid composition for electronic cigarettes of the present invention can be naturally derived."

Among them, those containing caffeine in plants are preferable, and those contained in (parts of) plants such as seeds contained in fruits such as coffee trees, guarana, and cacao trees, tea leaves, etc. are easy to produce. In addition, being naturally derived is more preferable because "all of the components contained in the liquid composition for electronic cigarettes of the present invention can be naturally derived".

As the caffeine, it is also preferable to directly use the caffeine contained in foods and drinks such as coffee, coffee beverages, guarana, guarana beverages, green tea, oolong tea, black tea, mate tea, cocoa, and chocolate.
At that time, the liquid composition for electronic cigarettes may contain "water" and "components other than caffeine" contained in these foods and drinks as they are, and the water contained in these may be described later. It can also be used as a "solvent" to

The method for extracting caffeine from plants is not particularly limited, but it can be extracted by a supercritical fluid extraction method, a subcritical fluid extraction method, a steam distillation method, an aqueous solvent extraction method, an organic solvent extraction method, a heat sublimation method, or the like. . Examples of the supercritical fluid include carbon dioxide.

<Solvent>
The liquid composition for electronic cigarettes of the present invention contains a solvent as an essential component. That is, the liquid composition for electronic cigarette contains at least cannabinoid and caffeine dissolved in the solvent.

The main component of the solvent is preferably an alcoholic solvent and/or water. That is, an alcohol-based solvent may be the main component, water may be the main component, or a "mixed solvent of water and an alcohol-based solvent" may be the main component. Among them, one containing an alcohol-based solvent as a main component is preferable. Here, the term "principal component" is defined in the same manner as described above.
"Alcohol-based solvent and/or water" may be used alone or in combination of two or more.

As the alcoholic solvent, one approved as a food additive is preferable, and a "naturally derived alcoholic solvent" such as vegetable glycerin is preferable.
Specifically, glycerin and/or glycol are preferable as the alcoholic solvent. The "glycerin" also includes polyglycerin such as diglycerin. Preferred glycols include propylene glycol, dipropylene glycol, 1,3-butylene glycol and the like.
The glycol preferably has a boiling point higher than that of propylene glycol. "Glycerin and/or glycol" may be used alone or in combination of two or more.

The water may be purified water, and water in beverages containing caffeine or the like can also be used as the solvent. For example, water contained in liquids (drinks) such as fruit juice such as guarana, tea, coffee, and cocoa may be used.

<Perfume>
Although the liquid composition for electronic cigarettes of the present invention is not particularly limited, it preferably further contains a fragrance. Any of natural fragrances, synthetic fragrances and compounded fragrances can be used as the fragrance. It can also be used as a flavor (food additive) or as a fragrance (cosmetic fragrance).
The types of scents of the perfume include citrus-based, floral-based, fruit-based, milk-based, chypre-based, oriental-based, (preferred) food and beverage-based, ready-made (preferred) smoking equipment-based, vanilla-based, mint-based, and sweetener-based. , spices, nuts, and alcoholic beverages.

Among them, citrus-based, fruit-based, mint-based fragrances that give a refreshing feeling; (preferred) food and drink-based flavors such as chocolate, milk, and coffee that give a feeling of relaxation; vanilla-based, floral-based, sweetener-based, etc. sweeteners. Fragrance to be felt; and the like are preferable.

Moreover, as the flavoring agent, a spearmint extract, menthol, a substance having a flavor (fragrance) of cannabis, a substance having a flavor (fragrance) of tobacco, and the like are preferable.
The "substance having the flavor (fragrance) of cannabis" is preferably a substance other than "substances contained in mature hemp stalks or seeds", and the "substance having the flavor (fragrance) of tobacco". is preferably a substance other than nicotine.

Flavors contained in foods and drinks containing caffeine such as tea, coffee, and guarana juice can also be suitably used. In that case, the flavor actually contained can be blended as it is (for example, "caffeine beverage containing flavor" itself can be blended), or only the flavor can be newly blended. .
By blending the perfume, the awakening effect and the calming effect can be enhanced, and the palatability effect can also be enhanced.

<Other ingredients>
The liquid composition for electronic cigarettes of the present invention may contain "other ingredients" in addition to the above-described components. "Other ingredients" include edible oils such as jojoba oil, grapeseed oil, sesame oil, coconut oil, and olive oil; naturally occurring ingredients such as beeswax, sugar, oxytocin, tyrosine, tryptophan, and melatonin; herbal medicine; and the like.

<Content>
With respect to 100 parts by mass of the solvent, the cannabinoid is preferably contained in an amount of 1 part by mass or more and 300 parts by mass or less, more preferably 1.3 parts by mass or more and 100 parts by mass or less, and 2 parts by mass or more and 30 parts by mass. It is more preferable to contain it by mass parts or less, and it is particularly preferable to contain it by 3 to 10 mass parts.
If it is less than the above lower limit, the sedative effect may not be obtained, or both sedative and awakening effects may not be obtained. In some cases, the effect and the awakening effect cannot be achieved at the same time.

Further, the caffeine is preferably contained in an amount of 0.01 parts by mass or more and 10 parts by mass or less, more preferably 0.03 parts by mass or more and 4 parts by mass or less with respect to 100 parts by mass of the solvent. More preferably 0.1 parts by mass or more and 2 parts by mass or less, and particularly preferably 0.2 parts by mass or more and 1 part by mass or less.
If it is less than the above lower limit, there may be cases where the awakening effect cannot be obtained. .

The perfume is preferably contained in an amount of 2 parts by mass or less, and particularly preferably in an amount of 0.001 part by mass or more and 1 part by mass or less with respect to 100 parts by mass of the solvent.

<Manufacturing method>
The liquid composition for electronic cigarettes of the present invention can be produced by dissolving cannabinoids, caffeine, and preferably flavorings in a solvent.
The cannabinoids can be formulated in the form of extracts or oils containing them, or cannabinoid crystals (mixtures) such as cannabidiol (CBD) crystals (in the form of single compounds) and dissolved. You can also use

The caffeine can be blended in the form of an extract containing it, a caffeine drink, or can be blended in the form of pure caffeine and dissolved before use.

When the perfume and "other ingredients" mentioned above are contained, the method of blending is not particularly limited, and is carried out according to a conventional method.
The above components may be blended at the same time and dissolved by stirring, or one component may be blended and dissolved first, and then the other component may be blended and dissolved.

The dissolution temperature, dissolution time, stirring conditions, etc. are not particularly limited, and the dissolution is carried out according to a conventional method. ° C. or less is particularly preferred.
The dissolution time or stirring time is preferably 1 minute or more and 2 hours or less, more preferably 2 minutes or more and 1 hour or less, and particularly preferably 5 minutes or more and 40 minutes or less.

The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these Examples unless it exceeds the gist of the invention.

Preparation example 1
<Contains cannabinoids and caffeine>
A solvent was prepared by mixing 7 g of vegetable glycerin and 3 g of propylene glycol, and while maintaining the liquid temperature in the range of 30 ° C to 80 ° C, cannabidiol (CBD) extracted from hemp stems and seeds was added to the solvent. ) was added and stirred for 20 minutes. Then, 0.03 g of pure caffeine was added and stirred for 20 minutes.
Thereafter, 3 drops (0.1 g) of coffee flavoring (manufactured by Capella) was added with a dropper, and the mixture was uniformly mixed and stirred to prepare a liquid composition for electronic cigarette (1).

Preparation example 2
<Contains caffeine (no cannabinoids)>
A liquid composition for electronic cigarette (2) was prepared in the same manner as in Preparation Example 1, except that cannabidiol (CBD) was not added.

Preparation example 3
<Contains cannabinoids (does not contain caffeine)>
A liquid composition for electronic cigarette (3) was prepared in the same manner as in Preparation Example 1, except that caffeine was not added.

Preparation example 4
<Contains no cannabinoids or caffeine)>
A liquid composition for electronic cigarette (4) was prepared in the same manner as in Preparation Example 1, except that neither cannabidiol (CBD) nor caffeine was added. That is, the electronic cigarette liquid composition (4) contains only solvents (glycerin and propylene glycol).

Evaluation example 1
<Evaluation method>
Four types of electronic cigarette liquid compositions (1) to (4) are filled in a rechargeable, cylindrical electronic cigarette device manufactured by JUSTFOG, H113.5 × W20 × D20 mm, 82.9 g, Human subjects inhaled. Subjects were asked to inhale each of the four types without informing them of the contents.
The calculation effect was evaluated on two separate days, and the subjects were asked to record their sleep status on that day (sleep-sleep effect) and the wake-up status on the next day (wake-up effect).

The calculation problem used to evaluate the calculation effect is the addition of two numbers randomly selected from 1 to 20, 1200 [questions] (120 [questions/set] x 10 [set]). was solved, and the time taken for each [set] was measured and recorded.
Then, the measured (recorded) 10 "answer times for 120 questions" were averaged, and the average values of the 5 subjects were taken as the "calculation time".

<Day 1>
1200 [questions] (120 [questions/set]×10 [sets]) were solved without aspiration, and the “control calculation time”, which is the “calculation time” of the control (reference), was recorded.
After that, the electronic cigarette filled with one of the electronic cigarette liquid compositions of (1) to (4) was sucked normally 10 times, and then 1200 [questions] were solved again, It was set as "calculation time on the first day". The evaluation was performed for each of the electronic cigarette liquid compositions (1) to (4).

The subjects were asked to record their sleeping situation on that day (sleep-sleep effect) and the wake-up situation on the next day (morning morning) (wake-up effect).

<Day 2>
For each of the electronic cigarette liquid compositions (1) to (4), the calculation problem was solved in the same manner as on the first day, and the average for each set was similarly calculated as the "calculation time on the second day".

The subjects were asked to record their sleeping situation on that day (sleep-sleep effect) and the wake-up situation on the next day (morning morning) (wake-up effect).

<Judgment Criteria>
<<Calculation effect>>
◎: The calculation time was shortened by 10% or more compared to the control calculation time. ○: The calculation time was shortened by 3% or more and less than 10% compared to the control calculation time. The calculation time was the same as the control calculation time or decreased by less than 3% ×: The calculation time was longer than the control calculation time

<< Sleeping situation (sleep effect) >>
◎: I was able to go to bed quickly ○: I was able to go to bed relatively early △: I was able to go to bed as usual (I was able to fall asleep)
×: It was difficult to fall asleep and it was difficult to go to bed

<< wake-up situation (wake-up effect) >>
◎: I was able to wake up feeling very good ○: I was able to get up relatively early △: I was able to get up as usual (I was able to wake up)
×: It was hard to get up and I didn't feel well.

<<Awakening effect>>
◎: The calculation effect is ○ or more and the wake-up effect is ○ or more ○: The calculation effect is ○ or more and the wake-up effect is △ △: The calculation effect is △ ×: From the above judgment Bad, does not belong to the above judgment

<< Calming effect >>
◎: The calculation effect is ○ or more and the sleeping effect is ○ or more ○: The calculation effect is △ and the sleeping effect is ○ or more △: The calculation effect is △ and the sleeping effect is △ ×: regardless of the determination of the calculation effect, the sleeping effect is × <result>
The results of Evaluation Example 1 are summarized in Table 1 below for four liquid compositions (1) to (4) for electronic cigarettes.

Only the liquid composition for electronic cigarettes (1) showed higher wakefulness effect and sedative effect than the liquid composition for electronic cigarettes (4), and both of them were possible.
On the other hand, the liquid compositions for electronic cigarettes (2) and (3), which do not contain either cannabinoid or caffeine, have either a stimulating effect or a sedative effect compared to the liquid composition for electronic cigarettes (4). Only one was higher or less than the same, and it was impossible to combine the effects.

Preparation example 5
Liquid compositions for electronic cigarettes (1b), (2b), (3b), and (4b) were prepared in the same manner as in Preparation Examples 1 to 4, except that the coffee flavor was not added in Preparation Examples 1 to 4.

<Results>
When the liquid compositions for electronic cigarettes (1b) to (4b) were evaluated according to Evaluation Example 1, they did not smell like coffee and were slightly tasteless, but the results were exactly the same as those shown in Table 1.

Preparation example 6
Instead of the pure caffeine used in Preparation Examples 1 and 2, a concentrated coffee liquid (including water as a solvent) was blended in the same manner as in Preparation Example 1 so as to be 0.03 g in terms of caffeine, Liquid compositions for electronic cigarettes (1c), (2c), (3), and (4) were prepared in the same manner as in Preparation Examples 1 to 4 except for the above.

<Results>
When the liquid compositions for electronic cigarettes (1c), (2c), (3), and (4) were evaluated according to Evaluation Example 1, the results were exactly the same as those shown in Table 1, although the flavor was slightly lacking in depth. was taken.

Preparation Example 7
Instead of blending "cannabidiol (CBD) crystals extracted from hemp stems and seeds" in Preparation Examples 1 and 3, tetrahydrocannabinol (THC) extracted from mature hemp stems and seeds A so-called "full spectrum" containing other cannabinoids, which does not contain , liquid compositions for electronic cigarettes (1d), (2), (3d), and (4) were prepared.

<Results>
When the electronic cigarette liquid compositions (1d), (2), (3d), and (4) were evaluated according to Evaluation Example 1, the wake-up effect was slightly inferior to the results in Table 1, but the results shown in Table 1 were obtained. Similar results were obtained.

The liquid composition for electronic cigarettes of the present invention and the electronic cigarettes using the same have both a stimulating effect and a sedative effect, and are suitable for both people with diseases and healthy people. It is widely used in the fields of medical care and nursing, smoking cessation products, luxury goods, sports, examinations for qualifications, business, and the like.

Claims (6)

A liquid composition for an electronic cigarette that releases an active ingredient contained in the liquid composition by heating the liquid composition,
A liquid composition for electronic cigarettes containing at least cannabidiol (CBD) derived from crystals extracted from hemp stems or seeds, caffeine, and a solvent , and not containing tetrahydrocannabinol (THC) ,
Cannabinoids extracted from hemp stems or seeds contain only cannabidiol (CBD),
the solvent is glycerin and/or glycol and/or water;
A liquid composition for an electronic cigarette, comprising 2 parts by mass or more and 30 parts by mass or less of cannabidiol (CBD) and 0.03 parts by mass or more and 4 parts by mass or less of caffeine with respect to 100 parts by mass of the solvent. . The liquid composition for electronic cigarettes according to claim 1, wherein 3 parts by mass or more and 10 parts by mass or less of cannabidiol (CBD) is contained with respect to 100 parts by mass of the solvent. 3. The liquid composition for electronic cigarettes according to claim 1, wherein the liquid composition for electronic cigarettes contains 0.1 parts by mass or more and 2 parts by mass or less of caffeine with respect to 100 parts by mass of the solvent. 4. The liquid composition for electronic cigarettes according to any one of claims 1 to 3, wherein the caffeine is contained in plants. 5. The liquid composition for electronic cigarettes according to any one of claims 1 to 4 , further comprising a fragrance. An electronic cigarette comprising the liquid composition for an electronic cigarette according to any one of claims 1 to 5 .