JP7298268B2 - chemical injection controller - Google Patents

Description

TECHNICAL FIELD The present invention relates to a liquid medicine injection controller capable of performing rapid injection of liquid medicine by self-operation in a liquid medicine administration apparatus that continuously injects liquid medicine.

2. Description of the Related Art Conventionally, a drug solution administration device that continuously administers a drug solution has been known, and is used, for example, when administering an analgesic or an anesthetic into the body continuously in small amounts. In addition, the drug solution administration device may include a drug solution injection controller that enables rapid administration of the drug solution by self-operation. The drug solution injection controller has a sub-reservoir that stores the drug solution. For example, when the patient performs a self-operation such as pushing a pressing operation member, the drug solution stored in the sub-reservoir of the drug solution injection controller is injected into the patient's body. Administered rapidly.

By the way, the liquid medicine injection controller needs to prevent over-dosing of the liquid medicine because the liquid medicine is rapidly injected by the patient's own operation.

However, as a result of investigations by the present inventors, it has become clear that, with conventional liquid medicine injection controllers, it is sometimes difficult to accurately manage the amount of liquid medicine to be rapidly administered and the interval between injections, which is an unsolved problem.

The problem to be solved by the present invention is to provide a liquid medicine injection controller with a novel structure that facilitates control of the dose of the liquid medicine and prevents overdosing of the liquid medicine.

Hereinafter, preferred embodiments for understanding the present invention will be described. can be recognized and employed as independently as possible, and can also be employed in combination with any of the components described in other aspects as appropriate. Accordingly, the present invention can be implemented in various alternatives without being limited to the embodiments described below.

In a first aspect, a pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates a sub-reservoir, and is provided on the housing side to move onto the movement path of the pressing operation member. The lock mechanism has a movable member that restricts the movement of the pressing operation member due to the pressing operation by entering from the side , and the movable member is moved to the pressing operation member by filling the sub-reservoir with the chemical solution. The liquid injection controller is provided with a lock release mechanism that releases the movement restriction of the pressing operation member by the lock mechanism by moving it sideways from the movement path .

According to the drug solution injection controller of this aspect, for example, after the patient presses the push operation member to rapidly inject the drug solution, the movement of the push operation member in the push direction is restricted by the lock mechanism. As a result, it is possible to prevent re-administration of the drug solution before the sub-reservoir is filled with a predetermined amount of the drug solution, which facilitates management of the dose of the drug solution. Excessive administration can also be prevented.

When the sub-reservoir is filled with a predetermined amount of liquid medicine, the unlocking mechanism releases the movement restriction of the pressing member by the locking mechanism. This makes it possible to press the pressing member again. In this way, when the sub-reservoir is filled with a predetermined amount of liquid medicine, rapid administration of the liquid medicine by the patient's own operation is allowed. Therefore, administration of a predetermined amount at intervals of a predetermined time or more is realized, and the effect of the liquid medicine can be obtained effectively, and safety against self-administered drug administration can be improved.

In a second aspect, a pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates a sub-reservoir, and a lock mechanism is provided to restrict movement of the pressing operation member by pressing operation. and an unlocking mechanism for releasing the movement restriction of the pressing operation member by the locking mechanism when the sub-reservoir is filled with the chemical solution, and the sub-reservoir is opened by the pressing operation of the pressing operation member. A plunger is provided for compressing and discharging the drug solution, and a slider is provided between the pressing member and the plunger, the slider being displaceable relative to the pressing member and the plunger. adopting a first spring and a second spring which are different and exert a spring force between the plunger and the pressing member, disposing the first spring between the pressing member and the slider; In the liquid injection controller, the second spring having a spring constant smaller than that of the first spring is arranged between the slider and the plunger.

According to the liquid injection controller of this aspect, the first spring and the second spring are arranged in series between the pressing member and the plunger via the slider, so that each spring characteristic of the first spring and the second spring is is adjusted, it is possible to set, with a large degree of freedom, the feeling of operation when the pressing operation member is pressed. For example, when the pressing operation member is pressed, a large pressing force based on the elasticity of the first spring is applied to the sub-reservoir from the plunger, and a small pressing force based on the elasticity of the second spring is applied to the sub-reservoir after the liquid medicine is discharged. to be exerted. As a result, both efficient discharge of the chemical solution from the sub-reservoir and efficient filling of the sub-reservoir with the chemical solution are achieved.

In a third aspect, a pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates a sub-reservoir, and a lock mechanism is provided to restrict movement of the pressing operation member due to pressing operation. and an unlocking mechanism for releasing the movement restriction of the pressing operation member by the locking mechanism when the sub-reservoir is filled with the chemical solution, and the sub-reservoir is opened by the pressing operation of the pressing operation member . The chemical solution injection controller is provided with a guide member for guiding a plunger that presses and discharges the chemical solution in the reciprocating direction of the pressing operation member.

According to the liquid injection controller of this aspect, when the plunger is moved by the pressing operation of the pressing operation member, the plunger is guided by the guide member, thereby preventing inclination of the plunger and achieving stable operation. .

In a fourth aspect, a pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates a sub-reservoir, and a lock mechanism is provided to restrict movement of the pressing operation member by pressing operation. and an unlocking mechanism for releasing the movement restriction of the pressing operation member by the locking mechanism when the sub-reservoir is filled with the chemical solution, and the pressing operation member is engaged with the pressing operation member . A locking pawl is provided to hold the pressing operation member in the pushed position, and when the chemical solution is discharged from the sub-reservoir, a pressing force is exerted on the locking pawl to perform the pressing operation of the locking pawl. The liquid injection controller is provided with an unlocking portion for unlocking a member, and further provided with a return spring for reducing a pressing force exerted from the unlocking portion on the locking claw. .

According to the chemical injection controller of this aspect, for example, even when the pressing force is continuously applied from the unlocking portion to the locking claw, the pressing force exerted from the unlocking portion to the locking claw by the return spring is reduced. reduced to prevent plastic deformation of the pawl.

In a fifth aspect, a pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates a sub-reservoir, and the pressing operation member slides from the side onto a movement path by pressing operation. A liquid injection controller, wherein a movable member for restricting the movement of the pressing member in the pressing direction by entering is provided in an independent state that is not connected to the pressing member.

According to the liquid injection controller of this aspect, since the movable member for blocking the pressing operation of the pressing operation member is provided, for example, by appropriately setting the cancellation condition for the blocking of the pressing operation by the movable member, the liquid medicine injection by the patient can be performed. It becomes possible to avoid overdosing of Moreover, since the movable member slides into the moving path of the pressing operation member from the side, it is possible to arrange the movable member in a smaller space than in the swing mechanism. It also becomes easier to secure the allowable stroke. In addition, since the movable member is provided in an independent state without being connected to the pressing operation member via a link mechanism or the like, adverse effects on the pressing operation of the pressing operation member are avoided, and the mechanism becomes complicated. can also be reduced.

A sixth aspect is the liquid injection controller according to the fifth aspect, wherein the movable member moves onto the moving path of the pressing operation member from an outside position where the entirety is out of the moving path of the pressing operation member. It's something to enter.

According to the liquid injection controller of this aspect, when the pressing operation of the pressing operation member is not blocked, the movable member is completely removed from the moving path of the pressing operation member, and the pressing operation member can perform the pressing operation more stably. It becomes possible.

A seventh aspect is the chemical injection controller according to the fifth or sixth aspect, wherein the movable member is assembled so as to be able to reciprocate while being guided by a guide portion provided on the housing. is.

According to the liquid injection controller of this aspect, the movable member is guided by the wall-shaped guide portion provided so as to surround the entire circumference or partially surround the circumference, for example. Therefore, tilting of the movable member can be suppressed, and the stroke stability of the movable member can be improved.

An eighth aspect is the chemical injection controller according to any one of the fifth to seventh aspects, wherein the movable member is biased in a direction of entering onto a moving path according to the pressing direction of the pressing member. A force means is provided.

According to the liquid injection controller of this aspect, the pressing operation blocking state of the pressing operation member can be easily and stably maintained by the positioning action of the movable member by the biasing force of the biasing means.

A ninth aspect is the liquid medicine injection controller according to any one of the fifth to eighth aspects, wherein the movable member is provided with a locking protrusion projecting toward the pressing member. When the pressing operation member comes into contact with one side surface of the lock projection, the movement of the pressing operation member in the pressing direction is restricted, and the other side of the lock projection is regulated. When the unlocking member, which moves as the sub-reservoir is filled with the liquid medicine, comes into contact with the side surface, the movement restriction of the pressing member in the pressing direction by the movable member is released. It is.

According to the liquid injection controller of this aspect, since the pressing operation of the pressing operation member can be regulated by the lock projection partly protruding from the movable member, the main body portion of the movable member that is larger than the lock projection can be used during movement. Stability can be ensured, and movement restrictions of the pressing operation member can be released using the lock projection. can also be kept small.

ADVANTAGE OF THE INVENTION According to this invention, management of the dosage of a chemical|medical solution is easy and it can prevent excessive administration of a chemical|medical solution.

1 is a perspective view showing a liquid injection controller as a first embodiment of the present invention; FIG. 2 is a perspective view showing the liquid injection controller shown in FIG. 1 with the upper half of the housing removed; FIG. FIG. 2 is a perspective view showing the liquid injection controller shown in FIG. 1 with the lower half of the housing removed; FIG. 5 is a cross-sectional view of the chemical injection controller shown in FIG. 1, corresponding to the IV-IV cross section of FIG. VV sectional view of FIG. VI-VI sectional view of FIG. VII-VII cross-sectional view of FIG. VIII-VIII sectional view of FIG. 2 is a perspective view of a movable member that constitutes the liquid injection controller shown in FIG. 1; FIG. 10 is a perspective view showing the movable member of FIG. 9 at another angle; FIG. FIG. 10 is a plan view showing a state in which the movable member of FIG. 9 is inserted into the guide tube portion of the housing; FIG. 14 is a cross-sectional view showing a state in which priming is completed in the liquid injection controller shown in FIG. 4, and is a view corresponding to the XII-XII cross section of FIG. 14; XIII-XIII sectional view of FIG. XIV-XIV sectional view of FIG. FIG. 17 is a cross-sectional view showing a state in which the push button is pressed in the liquid injection controller shown in FIG. 4, and corresponds to the XV-XV cross section of FIG. 16; XVI-XVI sectional view of FIG. FIG. 18 is a cross-sectional view showing a state in which rapid chemical injection is completed in the chemical injection controller shown in FIG. 5, and corresponds to the XVII-XVII cross section of FIG. 18; XVIII-XVIII sectional view of FIG. FIG. 21 is a cross-sectional view showing a state in which the push button has returned to the initial position in the liquid injection controller shown in FIG. 4, and is a view corresponding to the XIX-XIX cross section of FIG. 20; XX-XX sectional view of FIG.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described with reference to the drawings.

FIG. 1 shows a liquid injection controller 10 as a first embodiment of the present invention. The liquid medicine injection controller 10 is for a patient, who is a user, to perform rapid liquid medicine injection by self-operation, and as shown in FIGS. structure. 2, the upper half of the housing 12 is omitted, and the lower half of the housing 12 is omitted in FIG. In the following description of the liquid injection controller 10, as a general rule, the up-down direction is the left-right direction in FIG. 5, the front-rear direction is the up-down direction in FIG. Say left and right respectively.

More specifically, the housing 12 is made of hard synthetic resin or the like. The housing 12 has a hollow shape whose longitudinal direction is the front-rear direction as a whole, more specifically, a substantially cylindrical shape with a bottom. The housing 12 has a flat, hollow cross-sectional shape over a wide range except for the rear end portion, and has a hollow, substantially oval cross-section in this embodiment. As a result, the longitudinal direction of the housing 12 in cross section is the vertical direction, and the minor axis direction is the left-right direction. The flat cross-sectional shape referred to here is not limited to an elliptical cross-section, and may be, for example, a flat polygonal cross-section. Preferably, the housing 12 is sized to be grasped in one hand by a patient and has a gripping surface 16 on its outer circumference for gripping by the patient.

A sub-reservoir 14 is accommodated in the housing 12 . As shown in FIGS. 4 to 8, the sub-reservoir 14 is constructed by covering the opening of a cup-shaped diaphragm portion 18 with a base member 20 .

The diaphragm portion 18 is made of rubber, resin elastomer, or the like, and has flexibility. The diaphragm portion 18 is substantially cup-shaped in a stationary state where no external force acts. A flange-like clamping portion 22 protruding to the outer periphery is integrally formed in the opening portion of the diaphragm portion 18 over the entire circumference. The inner peripheral portion of the bottom portion 24 of the diaphragm portion 18 is thicker than the outer peripheral portion. It is said that In the present embodiment, the thick inner peripheral portion of the bottom portion 24 of the diaphragm portion 18 protrudes forward in a spherical crown shape with respect to the thin outer peripheral portion. In addition, the curvature of the front surface of the crown-shaped protruding portion in the inner peripheral portion of the bottom portion 24 of the diaphragm portion 18 is smaller than the curvature of the concave surface forming the rear surface of the base member 20 . As a result, the residual amount of the liquid medicine in the contracted sub-reservoir 14 is reduced, and the bottom portion 24 of the diaphragm portion 18 is less likely to stick to the rear surface of the base member 20 .

A bottom portion 24 of the diaphragm portion 18 is integrally formed with a positioning projection 28 projecting rearward from the center. The positioning projection 28 is rod-shaped, and has a tapered portion 30 at its distal end, the diameter of which decreases toward the distal end. The large-diameter end portion of the tapered portion 30 has a larger diameter than the base end portion of the positioning projection 28 outside the tapered portion 30 to form a step.

A pair of return springs 32, 32 projecting rearward are integrally formed on the bottom portion 24 of the diaphragm portion 18. As shown in FIG. The return spring 32 is provided at a position spaced outward in the left-right direction from the positioning projection 28 . The return spring 32 has a projection dimension smaller than that of the positioning projection 28 . The return spring 32 has a tapered shape in which the cross-sectional area gradually decreases toward the projecting tip. A specific shape of the return spring 32 is merely an example and is not particularly limited. For example, the return spring 32 may have an annular shape that continues in the circumferential direction.

The base member 20 is made of hard synthetic resin or the like and has a substantially disk shape. The base member 20 is formed such that a cylindrical liquid medicine inflow portion 34 and a liquid medicine outflow portion 36 are formed in a penetrating state. A plurality of engaging protrusions 38 protrude rearward (upward in FIG. 8) from the base member 20 . The base member 20 is connected to the guide member 40 by these engaging projections 38 .

The guide member 40 is made of hard synthetic resin or the like and has a substantially cylindrical shape. The guide member 40 is provided with a flange-shaped engaging portion 42 protruding toward the outer periphery at the front end portion. The base member 20 and the guide member 40 are connected in the axial direction by hooking the engaging projections 38 of the base member 20 on the engaging portions 42 . The engagement portion 42 of the guide member 40 is provided with locking hooks 44 as locking claws at two locations in the circumferential direction. The locking hook 44 integrally includes a plate-like extension portion extending rearward from the engaging portion 42 and a claw portion projecting from the tip of the extension portion toward the outer periphery. The rear surface of the locking hook 44 has an inclined shape that is inclined forward toward the outer circumference.

The diaphragm portion 18 is inserted into the inner peripheral side of the guide member 40 . The holding portion 22 of the diaphragm portion 18 is sandwiched and supported between the base member 20 and the guide member 40 in the axial direction (front-rear direction), so that the diaphragm portion 18 is assembled to the base member 20 and the guide member 40. It is In such an assembled state, the opening of the diaphragm portion 18 is liquid-tightly closed by the base member 20 to form the sub-reservoir 14 . Further, the inner space of the sub-reservoir 14 communicates with the internal lumens of the liquid medicine inflow portion 34 and the liquid medicine outflow portion 36 penetrating the base member 20 .

The sub-reservoir 14 is positioned with respect to the housing 12 by attaching the base member 20 and the guide member 40 to the housing 12 . A bottom portion 24 of the diaphragm portion 18 is movable in the front-rear direction with respect to the housing 12, and is allowed to expand and contract in the front-rear direction.

A plunger 46 is superimposed on the bottom portion 24 of the diaphragm portion 18 . As shown in FIGS. 4 to 7, the plunger 46 has a structure in which a plunger body 48 and an outer peripheral guide portion 50 are integrally connected at the rear end portion.

The plunger main body 48 has a substantially bottomed cylindrical shape that opens toward the rear. The plunger main body 48 has a recess 52 linearly extending in the front-rear direction and having a circular cross section corresponding to the outer peripheral shape of a second coil spring 88, which will be described later. A fitting hole 54 is formed in the front wall portion of the plunger main body 48 so as to extend through the central portion thereof in the front-rear direction. By fitting the positioning protrusion 28 of the diaphragm portion 18 into the fitting hole 54, a positioning mechanism for positioning the plunger 46 and the bottom portion 24 of the diaphragm portion 18 relative to each other is configured.

The outer peripheral guide portion 50 has a tubular shape surrounding the outer periphery of the plunger main body 48 . The outer circumference guide portion 50 is partially shortened in length in the front-rear direction at two locations on the circumference, and unlocking portions 56 projecting to the outer circumference are formed at the front ends of the shortened portions. ing. The unlocking portion 56 is slanted forward toward the outer circumference, and has a slanted front surface. The unlocking portion 56 can be inserted into the inner periphery of a push button 62, which will be described later. The unlocking portions 56 , 56 are provided at positions corresponding to the locking hooks 44 , 44 of the guide member 40 in the circumferential direction, and protrude from the inner peripheral surface of each locking hook 44 to the outer circumference.

The outer peripheral guide portion 50 has a pair of protrusions 58a and 58b. The protrusions 58a and 58b have a substantially cylindrical shape with a small diameter. The projecting portions 58a and 58b protrude from the front end portion of the outer peripheral guide portion 50 toward the outer periphery on both sides in the radial direction substantially orthogonal to the radial direction in which the unlocking portions 56 and 56 are provided. In short, one protrusion 58a protrudes upward, and the other protrusion 58b protrudes downward. A sloped surface 60 that slopes outward toward the outer circumference is formed at the distal end portions of the protrusions 58a and 58b.

At least the front end portion of the outer peripheral guide portion 50 is fitted onto the guide member 40 . As a result, the movement of the plunger 46 provided with the outer peripheral guide portion 50 is guided in the front-rear direction by the guide member 40 . When the plunger 46 reciprocates in the front-rear direction, the plunger 46 is guided by the guide member 40 fixed to the housing 12, thereby preventing inclination of the plunger 46 and the like.

Also, the plunger 46 is inserted in a push button 62 as a pressing operation member. The push button 62 has a substantially bottomed cylindrical shape that opens forward. The opening of the push button 62 is inserted into the rear end portion of the housing 12 from the rear in the axial direction, and the push button 62 is assembled in the housing 12 so as to reciprocate in the longitudinal direction (front-rear direction). The bottom wall side of the push button 62 protrudes axially rearward from the rear end opening of the housing 12 . The rear surface of the push button 62 exposed from the housing 12 serves as a pressing operation surface 64 as a fingertip pressing surface, and the patient, who is the user, can press the grip surface 16 of the housing 12 with a thumb while gripping the gripping surface 16. .

A small-diameter cylindrical spring support portion 66 is integrally formed on the inner peripheral portion of the bottom wall portion of the push button 62 . The spring support portion 66 has an outer peripheral shape corresponding to the inner peripheral shape of a first coil spring 86 to be described later, and protrudes forward from the bottom wall portion of the push button 62 .

Slider engaging holes 68 extending in the axial direction are formed in the peripheral wall portion of the push button 62 at two locations in the circumferential direction. Further, hook locking holes 70 are formed in the peripheral wall portions of the push buttons 62, respectively. The hook locking hole 70 radially penetrates the peripheral wall portion of the push button 62 in front of the slider engaging holes 68 , 68 . A lock portion 72 is provided at the front end portion, which is the opening portion of the push button 62 . As shown in FIG. 5 , the lock portion 72 is provided in a portion of the push button 62 in the circumferential direction and protrudes downward (outer peripheral side) from the peripheral wall portion of the push button 62 .

Further, as shown in FIGS. 3 and 8, the push button 62 is integrally formed with a main moving piece 74 . The driving piece 74 protrudes forward from the open end of the push button 62 and extends to the outer circumference of the guide member 40 . Furthermore, the protruding tip portion of the driving piece 74 is made into two plate-like portions arranged in parallel. The projecting tip surfaces of these plate-like portions are sloped surfaces that are inclined in the vertical direction toward the tip side. The two plate-like portions may have the same shape, or may have different shapes.

4 to 7, a slider 76 is arranged between the plunger 46 and the push button 62 in the axial direction. The slider 76 is made of hard synthetic resin or the like. The slider 76 has a structure in which a substantially bottomed cylindrical central portion 78 and a substantially cylindrical outer cylindrical portion 80 arranged on the outer circumference of the central portion 78 are integrally connected at the rear end portion. there is

A central portion 78 of the slider 76 has an outer diameter smaller than the inner diameter of the plunger body 48 . This allows the central portion 78 of the slider 76 to be inserted into the inner periphery of the plunger body 48 with a gap. A through hole 82 is formed through the front wall portion of the central portion 78 of the slider 76 in the front-rear direction. The through hole 82 has a larger diameter than the fitting hole 54 of the plunger main body 48, so that the positioning projection 28 of the diaphragm portion 18 can be inserted with a gap.

The inner diameter of the outer cylindrical portion 80 of the slider 76 is substantially the same as or slightly larger than the outer diameter of the outer guide portion 50 of the plunger 46 . The outer diameter of the outer cylindrical portion 80 is substantially the same as or slightly smaller than the inner diameter of the push button 62 . The outer cylindrical portion 80 has an axial length shorter than that of the outer peripheral guide portion 50 . The outer cylindrical portion 80 of this embodiment has an axial length that is approximately half that of the outer peripheral guide portion 50 . Engagement protrusions 84 protruding toward the outer periphery are provided on both sides in the radial direction of the front end portion of the outer cylindrical portion 80 . The engagement projection 84 is inserted into the slider engagement hole 68 of the push button 62 , and the amount of relative displacement between the slider 76 and the push button 62 in the front-rear direction is equal to the engagement projection 84 and the inner surface of the slider engagement hole 68 . is limited by the engagement of

The slider 76 has a central portion 78 inserted into the recess 52 of the plunger body 48 and an outer cylindrical portion 80 inserted into the inner circumference of the push button 62 . The slider 76 is thereby arranged between the plunger 46 and the push button 62 . Further, the slider 76 is not fixed to either the plunger 46 or the push button 62, and can be displaced relative to the plunger 46 and the push button 62 in the front-rear direction.

A first coil spring 86 as a first spring is arranged between the slider 76 and the push button 62 in the axial direction. The front end portion of the first coil spring 86 is inserted into the inner circumference of the central portion 78 of the slider 76 . The rear end portion of the first coil spring 86 is externally inserted into the spring support portion 66 projecting from the bottom wall portion of the push button 62 and positioned with respect to the push button 62 in the direction perpendicular to the axis. As a result, the first coil spring 86 is stably held in a predetermined arrangement extending between the slider 76 and the push button 62 in the front-rear direction.

Further, a second coil spring 88 as a second spring is arranged between the plunger 46 and the slider 76 in the axial direction. The front end portion of the second coil spring 88 is inserted into the inner circumference of the plunger body 48 . The rear end portion of the second coil spring 88 is fitted around the central portion 78 of the slider 76 . With these, both end portions of the second coil spring 88 are positioned in the direction perpendicular to the axis. Thereby, the second coil spring 88 is stably held in a predetermined arrangement state extending between the plunger 46 and the slider 76 in the front-rear direction. The spring constant of the second coil spring 88 is made smaller than the spring constant of the first coil spring 86 .

Thus, a first coil spring 86 is arranged between the slider 76 and the push button 62 and a second coil spring 88 is arranged between the plunger 46 and the slider 76 . In other words, the first and second coil springs 86 and 88 are arranged between the plunger 46 and the push button 62, and the first and second coil springs 86 and 88 are arranged in series via the slider 76. there is As a result, the plunger 46 , the push button 62 and the slider 76 can be relatively displaced in the front-rear direction with the elastic deformation of the first coil spring 86 and the second coil spring 88 . Spring forces of the first coil spring 86 and the second coil spring 88 are applied between the plunger 46 and the push button 62 .

Before use, the liquid medicine injection controller 10 is not filled with the liquid medicine in the sub-reservoir 14 as shown in FIG. Therefore, the sub-reservoir 14 is contracted in the longitudinal direction, and the plunger 46 is positioned forward. Also, the push button 62 is at the rear end position of the reciprocating movement. As a result, the amount of compressive deformation of the first and second coil springs 86 and 88 arranged between the plunger 46 and the push button 62 is relatively small.

When the plunger 46 is positioned at the front of the reciprocating movement and the push button 62 is positioned at the rear end of the reciprocating movement, the forward movement of the push button 62 is restricted by the locking mechanism 90 .

The lock mechanism 90 includes a movable member 92 separate from the push button 62, as shown in FIG. That is, the movable member 92 is not connected to the push button 62 by a drive mechanism connected by a link member or the like, and is movable independently of the push button 62, and is a separate member from the push button 62. separately assembled as As shown in FIGS. 9 and 10, the movable member 92 has a substantially rectangular plate shape as a whole. As shown in FIG. 9, the movable member 92 has an engaging claw portion 94 as a locking projection projecting upward. In short, a small engaging claw portion 94 is partially protruded and integrally formed from a relatively large rectangular block plate-shaped main body portion. The locking claw portion 94 has a front side surface formed as an inclined surface 96 that inclines rearwardly upward in the protruding direction, and a rear side surface formed as a flat surface that extends substantially perpendicularly to the front-rear direction. . 10, the movable member 92 is provided with a circular spring insertion recess 98 that opens downward. The movable member 92 is provided with guide projections 100, 100 projecting outward from a pair of opposite sides positioned in the left-right direction, which is the oblique up-down direction in FIG.

As shown in FIGS. 5 and 11, the movable member 92 is inserted into a guide tube portion 102 as a rectangular tube-shaped guide portion provided in the lower half portion of the housing 12 . Thereby, the movable member 92 is guided by the inner peripheral surface of the guide tube portion 102 and is slidable in the vertical direction. The guide tube portion 102 is provided below the reciprocating push button 62 and linearly extends in the vertical direction. Further, as shown in FIG. 11, a pair of guide grooves 104, 104 corresponding to the pair of guide protrusions 100, 100 of the movable member 92 extend linearly in the inner peripheral surface of the guide tube portion 102 in the vertical direction. ing.

In this embodiment, the movable member 92 is accommodated in a portion of the housing 12 having a flat, hollow cross-sectional shape. Since the housing 12 has a flat cross-sectional shape with a long axis extending in the vertical direction, the movable member 92 that moves in the vertical direction can be accommodated with good space efficiency. Further, the movable member 92 is guided by the guide tube portion 102 so as to slide and reciprocate in a translational state without tilting. The entire movable member 92 is arranged outside completely away from the movement path by pushing the button 62 . When the movable member moves toward the push button 62 (left side in FIG. 5), the locking claw portion 94 of the movable member 92 slides from the side onto the movement path of the push button 62 (lock portion 72). It is designed to be able to restrict the movement of the push button 62 in the pressing direction.

A protrusion 106 protruding upward from the inner surface of the lower wall of the housing 12 is provided on the inner circumference of the guide tube portion 102 and arranged at a position corresponding to the spring insertion recess 98 of the movable member 92 in the vertical direction. there is Furthermore, an annular groove 108 extending in the circumferential direction of the protrusion 106 around the protrusion 106 of the housing 12 is formed in the inner periphery of the guide tube portion 102 so as to open upward.

A biasing member 110 as biasing means is provided between the movable member 92 and the lower wall of the housing 12 in the vertical direction. The biasing member 110 is a coil spring in this embodiment, and is arranged on the inner circumference of the guide tube portion 102 . The movable member 92 inserted into the guide tube portion 102 is urged upward by the urging member 110 . The biasing member 110 has its upper end inserted into the spring insertion recess 98 of the movable member 92 and its lower end inserted over the protrusion 106 and into the groove 108 .

Further, as shown in FIG. 4 , an inflow channel 112 and an outflow channel 114 are connected to the base member 20 of the sub-reservoir 14 . The inflow channel 112 can be switched from a communicating state to a blocked state by a shutoff valve 116 . The outflow channel 114 can be switched between a communicating state and a blocked state by a quick dosing valve 118 .

Furthermore, as shown in FIGS. 3 and 4, the inflow channel 112 is connected to a restrictive channel 120 that bypasses the portion blocked by the shutoff valve 116 . In addition, a flow rate control unit 122 is provided in front of the closing valve 116 and the rapid administration valve 118 in the inflow channel 112 and the outflow channel 114 to communicate the inflow channel 112 and the outflow channel 114 with each other. . The restricting channel 120 and the flow rate control section 122 have a channel cross-sectional area smaller than that of the inflow channel 112 and the outflow channel 114 to limit the flow rate (flow velocity) of the chemical solution.

As shown in FIGS. 2 to 4, in the liquid injection controller 10 having such a structure, an upstream external line 124 is connected to the inflow channel 112, and a downstream external line 126 is connected to the outflow channel 114. are connected to form a drug-solution administration device. A main line 128 is configured by the upstream external line 124 , the inflow channel 112 , the flow control section 122 , the outflow channel 114 and the downstream external line 126 . The main line 128 is a flow path that connects a main reservoir (not shown) and an administration port (not shown) connected to an indwelling needle or the like on the patient side without going through the sub-reservoir 14 . Further, a subline 130 is formed by the downstream side of the connecting portion of the flow control portion 122 in the inflow channel 112 and the upstream side of the connecting portion of the flow control portion 122 in the outflow channel 114 . The sub-line 130 is a channel branched from the main line 128 and connected to the sub-reservoir 14 .

Before use, the liquid injection controller 10 has, for example, the sub-reservoir 14 not filled with the liquid medicine contracted in the front-rear direction, and the plunger 46 positioned at the bottom 24 of the sub-reservoir 14, as shown in FIGS. is positioned forward. Furthermore, the push button 62 is positioned rearward by the elasticity of the first and second coil springs 86 and 88 . In this state, the unlocking portion 56 of the plunger 46 comes into contact with the locking hook 44 of the guide member 40, and bends the locking hook 44 leftward and rightward.

4 to 8, the plunger 46 is biased forward by a weak elastic force of the second coil spring 88. As shown in FIGS. Further, return springs 32, 32 provided at the bottom portion 24 of the sub-reservoir 14 are pressed against the plunger 46, and a rearward biasing force based on the elasticity of the return springs 32, 32 acts. As a result, the forward force acting on the plunger 46 is offset and reduced, and the pressing force exerted from the unlocking portion 56 of the plunger 46 to the locking hook 44 of the guide member 40 is reduced. Therefore, plastic deformation of the locking hook 44 due to creep or the like can be suppressed even when the locking hook 44 is held in this state for a long period of time, for example.

4 to 8, in which the plunger 46 is positioned forward and the push button 62 is positioned rearward, the locking claw portion 94 of the movable member 92, as shown in FIG. , the push button 62 is located on the front side of the lock portion 72 of the push button 62 . Then, the engaging claw portion 94 of the movable member 92 biased by the biasing member 110 is held at a position overlapping the lock portion 72 of the push button 62 in the front-rear direction. As a result, when the push button 62 attempts to move forward, the lock portion 72 of the push button 62 hits the locking claw portion 94 of the movable member 92, and the movable member 92 is locked from the side (lower side) of the push button 62 from advancing. Limited by As a result, the patient cannot push the push button 62 forward and exert a compressive force on the sub-reservoir 14 .

In this way, the movable member 92, which is separate from the push button 62, is inserted forward from the side (below) of the push button 62, and the movable member 92 and the push button 62 are locked in the front-rear direction. As a result, movement restriction of the push button 62 is easily realized. In addition, due to the structure in which the movable member 92 is inserted into the push button 62 from below and locked in the front-rear direction, the liquid injection controller 10 can be downsized in the front-rear direction, which is the reciprocating direction of the push button 62 .

Since the movable member 92 is inserted into the guide tube portion 102 of the housing 12, it is allowed to move vertically and its movement in the front-rear direction is restricted. Therefore, when the push button 62 is pushed forward and pressed against the movable member 92, the advancement of the push button 62 is effectively restricted by the movable member 92 locked from the side.

The drug-solution administration device including the drug-solution injection controller 10 performs priming, in which the main line 128 and the sub-line 130 are filled with a drug solution (priming solution) before starting administration. That is, in the initial state (state shown in FIGS. 4 to 8) of the chemical liquid injection controller 10 in which the shut-off valve 116 is open and the push button 62 is not pushed forward, the chemical liquid is fed from the main reservoir (not shown). As a result, the chemical liquid flow path including the main line 128 and the sub-line 130, and the sub-reservoir 14 are filled with the chemical liquid. Air in the liquid medicine flow path and the sub-reservoir 14 is pushed downstream by the liquid medicine and discharged to the outside through an administration port (not shown) or the like. By the completion of priming, the sub-reservoir 14 is filled with the chemical solution and expanded as shown in FIG. 12 .

After priming is completed, the switch member 134 integrated with the shutoff valve 116 is pushed downward, thereby moving the shutoff valve 116 integrated with the switch member 134 downward. As a result, as shown in FIGS. 12 and 13, the shut-off valve 116 is pressed against the inflow passage 112 in the direction perpendicular to the passage, and the inflow passage 112 is crushed at the intermediate portion against which the shut-off valve 116 is pressed. blocked. The upstream and downstream sides of the inflow channel 112 with respect to the portion blocked by the shutoff valve 116 are communicated with each other by the restricted channel 120, and the flow rate of the chemical solution per unit time is restricted by the restricted channel 120.

By moving the switch member 134 downward, as shown in FIG. 13, the vertical engagement between the switch member 134 and the rapid injection valve 118 is released, allowing the rapid injection valve 118 to move downward. be. As a result, the rapid injection valve 118 is moved downward by the biasing force of the coil spring 138 , and is pressed against the outflow passage 114 in the direction perpendicular to the flow passage of the outflow passage 114 . As a result, the outflow channel 114 is partially crushed by the rapid administration valve 118 to partially block the outflow channel 114 , thereby preventing the outflow of the liquid medicine from the sub-reservoir 14 .

The chemical liquid entering the inflow channel 112 from the upstream external line 124 flows through the flow control section 122 to the downstream external line 126 connected to the outflow channel 114 . As a result, the drug solution is continuously administered little by little into the patient's body through an indwelling needle (not shown) or the like connected to the main line 128 and the downstream external line 126 . It should be noted that the amount of the drug solution continuously administered into the patient's body per unit time is adjusted by the flow rate of the flow control section 122 .

When the sub-reservoir 14 is filled with the chemical solution by priming, the plunger 46 moves rearward as the sub-reservoir 14 extends in the longitudinal direction, as shown in FIG. Then, when the sub-reservoir 14 is filled with a predetermined amount of liquid medicine, the inclined surface 60 of the projecting portion 58b on the lower side of the plunger 46 is pressed against the inclined surface 96 of the locking claw portion 94 of the movable member 92 from the front. . As a result, the movable member 92 moves downward while being guided by the guide tube portion 102 . When the locking claw portion 94 of the movable member 92 is pushed until it moves below the push button 62 , the movable member 92 releases the push button 62 from advancing. As a result, the push button 62 can be pushed forward by the patient applying forward force to the push operation surface 64 of the push button 62 . When the sub-reservoir 14 is filled with the liquid medicine in this way, the movement restriction of the push button 62 by the lock mechanism 90 is released by the projection 58 b on the lower side of the plunger 46 . Thus, the unlocking mechanism of this embodiment is constituted by the projecting portion 58b on the lower side of the plunger 46. As shown in FIG. When the push button 62 is pushed, the projecting portion 58b of the plunger 46 is also pushed forward and separated from the movable member 92. Since the push button 62 is positioned further rearward than the lock portion 72 , the restriction on movement of the push button 62 in the pushing direction due to contact with the lock portion 72 can be maintained in a released state. Further, the locking claw portion 94 of the movable member 92 located behind the locking portion 72 of the push button 62 may be in sliding contact with the outer peripheral surface of the cylindrical peripheral wall portion of the push button 62, or may be slightly separated therefrom. good.

When performing rapid administration to temporarily increase the dose of the liquid medicine, the patient performs self-operation of pushing the push button 62 of the liquid injection controller 10 in a state where the lock of the push button 62 by the lock mechanism 90 is released. . When push button 62 is depressed by the patient, first coil spring 86 and second coil spring 88 are compressed between push button 62 and plunger 46, as shown in FIG. As a result, forward biasing force is applied to the plunger 46 based on the elasticity of the compressed first and second coil springs 86 and 88 .

By pushing the push button 62 forward, the locking hook 44 of the guide member 40 is axially locked against the inner surface of the hook locking hole 70 of the push button 62 . As a result, the push button 62 is held in the pushed position against the urging forces of the first and second coil springs 86 and 88, and the urging forces of the first and second coil springs 86 and 88 are applied to the plunger 46. efficiently exerted against

Further, when the push button 62 is pushed forward and moved forward, the driving piece 74 integrally formed with the push button 62 is pressed against the driven piece 136 integrally formed with the rapid administration valve 118, as shown in FIG. . As a result, the forward force input to the push button 62 is converted into an upward force and exerted on the rapid administration valve 118 . As a result, the quick dosing valve 118 moves upward against the urging force of the coil spring 138 , and the blocking of the outflow flow path 114 by the quick dosing valve 118 is released.

Further, when the push button 62 is pushed and the first coil spring 86 is compressed, the plunger 46 is strongly pressed against the diaphragm portion 18 of the sub-reservoir 14 by the biasing force of the first coil spring 86 . As a result, the bottom portion 24 of the diaphragm portion 18 is pushed forward by the plunger 46 . As a result, the internal pressure of the sub-reservoir 14 pressed by the plunger 46 increases, and the liquid medicine stored in the sub-reservoir 14 flows out to the downstream external line 126 through the outflow channel 114 that is in communication. . Then, the amount of drug solution administered into the patient's body through the downstream external line 126 is temporarily increased, and rapid drug solution administration is performed. In addition, the inflow channel 112 is blocked by the shutoff valve 116, and the inner diameter of the restricted channel 120 is made extremely small. Therefore, when the internal pressure of the sub-reservoir 14 increases, the chemical liquid in the sub-reservoir 14 is sent out to the outflow channel 114 without flowing back to the inflow channel 112 .

Thus, the depressed push button 62 compresses the first coil spring 86 rather than exerting a force exerted on the push button 62 by self-actuation directly on the plunger 46 . The repulsive force of the compressed first coil spring 86 is exerted on the plunger 46 so that the plunger 46 presses the sub-reservoir 14 . As a result, it is possible to prevent excessive pressure from acting on the sub-reservoir 14, improve the durability of the sub-reservoir 14, and efficiently push out the liquid medicine in the sub-reservoir 14. - 特許庁

Once the push button 62 is pushed, the liquid injection controller 10 is held at the position where the push button 62 is pushed. Therefore, by performing a pressing operation once for a short period of time, substantially the entire amount of the liquid medicine stored in the sub-reservoir 14 is administered over a predetermined period of time. Therefore, a patient using the drug solution injection controller 10 can administer a sufficient amount of drug solution with one push without continuously pressing the push button 62 .

In this embodiment, the movement of the plunger 46 is guided in the longitudinal direction by the guide member 40 , and the plunger 46 and the bottom portion 24 of the diaphragm portion 18 are mutually positioned by the positioning projections 28 . Therefore, when the diaphragm portion 18 of the sub-reservoir 14 is compressed by the movement of the plunger 46, displacement of the compressed position is prevented, and the diaphragm portion 18 is stably compressed.

The contact between the projection 58b on the lower side of the plunger 46 and the movable member 92 is released by the forward movement of the plunger 46. However, as shown in FIG. Movement to the is still restricted. That is, the front end of the push button 62 pushed forward is located forward of the movable member 92, and the upward movement of the movable member 92 is restricted by the peripheral wall of the push button 62, so that the movable member 92 is engaged. The locking claw portion 94 is held below the push button 62 .

When the rapid administration of the liquid medicine is completed, as shown in FIG. 18, the unlocking portion 56 of the plunger 46 that has moved forward comes into contact with the locking hooks 44 of the guide member 40, and the locking hooks 44 move left and right inward. flex. As a result, the engagement of the engagement hook 44 with respect to the inner surface of the hook engagement hole 70 of the push button 62 is released, allowing the push button 62 to move rearward with respect to the housing 12 . The plunger 46 is pushed forward with a strong force by the first coil spring 86 having a large spring constant. Therefore, the unlocking portion 56 of the plunger 46 is strongly pressed against the locking hook 44 of the guide member 40, and the locking hook 44 is bent inward in the left-right direction sufficiently.

Since the spring forces of the first and second coil springs 86 and 88 act on the push button 62 toward the rear, when the restriction of movement of the push button 62 by the locking hook 44 is released, the movement of the push button 62 is released as shown in FIG. , 20, the push button 62 is quickly moved rearward. Further, the slider 76 is integrated with the push button 62 by engaging the engagement projection 84 provided at the front end of the outer cylindrical portion 80 with the inner surface of the front end of the slider engagement hole 68 of the push button 62 . Move backwards. This causes push button 62 and slider 76 to move rearward relative to plunger 46 .

When the push button 62 moves rearward, the lock between the peripheral wall of the push button 62 and the movable member 92 is released, as shown in FIG. Further, when the push button 62 moves backward, the sub-reservoir 14 is in a contracted state in which almost no liquid medicine is contained, and the plunger 46 connected to the sub-reservoir 14 is moved forward. Therefore, the projecting portion 58 b on the lower side of the plunger 46 is separated from the movable member 92 , and the movable member 92 released from the engagement with the push button 62 moves upward due to the elasticity of the biasing member 110 . As a result, the engaging claw portion 94 of the movable member 92 moves to a position overlapping the locking portion 72 of the push button 62 in the front-rear direction, and the forward movement of the push button 62 is caused by contact with the engaging claw portion 94. Regulated. As a result, even if the patient tries to immediately push the push button 62 that has moved backward, it cannot be pushed.

Further, when the push button 62 moves rearward, the abutment between the main moving piece 74 of the push button 62 and the driven piece 136 of the quick dosing valve 118 is released. As a result, the quick dosing valve 118 is pressed against the outflow channel 114 by the urging force of the coil spring 138 , and the outflow channel 114 is switched to the closed state by the quick dosing valve 118 .

Furthermore, by moving the push button 62 and the slider 76 rearward, part of the chemical liquid sent from the main reservoir (not shown) to the upstream external line 124 flows through the inflow channel 112 and the restriction channel 120 into the sub-reservoir 14 . is filled to 19 and 20, when the push button 62 and the slider 76 move rearward, the compression amounts of the first and second coil springs 86 and 88 between the push button 62 and the plunger 46 become smaller. This reduces the compressive force exerted by the plunger 46 on the sub-reservoir 14 . Therefore, the drug solution is supplied to the sub-reservoir 14 through the inflow channel 112 and the restriction channel 120, and the drug solution in the sub-reservoir 14, which has decreased due to rapid administration, gradually increases. In addition, the time required to refill the sub-reservoir 14 with a predetermined amount of the chemical solution after the rapid administration of the chemical solution is adjusted by the restricted flow path 120, and by preventing excessive supply of the chemical solution to the sub-reservoir 14, Overdose of the drug solution is prevented.

In particular, in this embodiment, a first coil spring 86 and a second coil spring 88 having spring constants different from each other are provided. By returning the push button 62 and the slider 76 to their initial positions, the first coil spring 86 with a large spring constant is restored to its initial state, and the amount of compressive deformation of the second coil spring 88 with a small spring constant is reduced. . As a result, a weak force based on the elasticity of the second coil spring 88 acts forward on the plunger 46 to reduce the pressing force applied from the plunger 46 to the sub-reservoir 14 . Therefore, for example, the sub-reservoir 14 can be filled with a sufficient amount of the chemical solution without flowing the chemical solution with a large pressure.

A first coil spring 86 is provided between the push button 62 and the slider 76 and a second coil spring 88 is provided between the plunger 46 and the slider 76 . As a result, it is possible to keep the first coil spring 86 and the second coil spring 88 in a compressed state at all times. It is possible to prevent the occurrence of sound.

In addition, since the amount of compressive deformation of the first and second coil springs 86 and 88 is reduced, the forward force exerted on the plunger 46 from the first and second coil springs 86 and 88 is reduced. Therefore, the force exerted from the unlocking portions 56, 56 of the plunger 46 to the locking hooks 44, 44 of the guide member 40 is reduced. Furthermore, the force acting on the locking hooks 44, 44 is also reduced by the rearward force acting on the plunger 46 due to the elasticity of the return springs 32, 32 compressed in the longitudinal direction. In this way, by reducing the force acting on the locking hooks 44, 44, the amount of bending deformation of the locking hooks 44, 44 to the left and right inwards is reduced. deformation is suppressed.

As the amount of the chemical solution in the sub-reservoir 14 increases, the plunger 46 is pushed by the diaphragm portion 18 of the sub-reservoir 14 and moves backward. Then, the sub-reservoir 14 is filled with substantially the same amount of liquid medicine as before the rapid injection, so that the plunger 46 is moved to the standby position shown in FIG. 12 before executing the rapid liquid injection. When the sub-reservoir 14 is filled with a predetermined amount of the liquid medicine, the inclined surface 60 of the protrusion 58b on the lower side of the plunger 46 comes into contact with the inclined surface 96 of the locking claw portion 94 of the movable member 92, and the movable member 92 is closed. is pushed downward by the protrusion 58b. As a result, the restriction on forward movement of the push button 62 by the locking mechanism 90 is released by the unlocking mechanism, and the push button 62 can be pushed again. becomes possible.

As shown in FIG. 1, an upper protrusion 58a provided on the plunger 46 is inserted into a slit 140 passing through the peripheral wall of the housing 12 as a mark. The position of the plunger 46 relative to the housing 12 in the axial direction can be grasped from the outside by the position of the protrusion 58a in the slit 140. As shown in FIG. For example, the state in which the upper protrusion 58a has moved to the vicinity of the rear end of the slit 140 indicates the state in which the sub-reservoir 14 is filled with the liquid medicine (see FIG. 14). In the plunger 46 of the present embodiment, an upper projection 58a that constitutes a mark and a lower projection 58b that constitutes an unlocking mechanism are provided in shapes corresponding to each other. As a result, the plunger 46 has a rotationally symmetric shape of 180° in the circumferential direction, and when the plunger 46 is assembled, restrictions on the orientation are eased, thereby facilitating manufacturing.

In the liquid medicine injection controller 10 having such a structure according to the present embodiment, the push button 62 is locked so as not to be pushed by engagement with the movable member 92 when the sub-reservoir 14 is not filled with a predetermined amount of liquid medicine. be. Therefore, the patient cannot push the push button 62 many times in a short period of time, and rapid administration of the liquid medicine cannot be performed continuously. Therefore, the rapid administration of the liquid medicine is limited to a predetermined amount at intervals of a predetermined time or longer, thereby preventing excessive administration of the liquid medicine and facilitating control of the amount of the liquid medicine to be rapidly administered.

When the sub-reservoir 14 is filled with a predetermined amount of liquid medicine, the lock between the push button 62 and the movable member 92 is released, and the push button 62 can be pushed. Therefore, it is possible to rapidly administer a predetermined amount of the liquid medicine with a time interval at which the sub-reservoir 14 is filled with a sufficient amount of the liquid medicine. As a result, the safety of medication can be improved by preventing excessive administration of the drug solution, and the efficacy of the drug solution can be effectively obtained by administering an appropriate amount.

Although the embodiments of the present invention have been described in detail above, the present invention is not limited by the specific descriptions. For example, the number of springs provided between the plunger 46 and the push button 62 is not limited to two as in the above embodiment, but may be one or three or more. The spring constants of the first coil spring 86 and the second coil spring 88 may be the same.

Although the first coil spring 86 and the second coil spring 88 are arranged in series via the slider 76 in the above embodiment, the first coil spring 86 and the second coil spring 88 may be arranged in parallel. Specifically, for example, the lengths of the first coil springs 86 and the second coil springs 88 may be made different, and the first coil springs 86 and the second coil springs 88 may be arranged in parallel in an internal and external insertion state. . According to this, when pushing the push button 62, only the second coil spring 88 is compressed halfway, and both the first and second coil springs 86, 88 are compressed halfway. It is possible to give the patient a change in response during self-operation.

The slider 76 is not an essential component in the present invention and can be omitted. Further, it is not necessary to provide springs between the push button 62 and the slider 76 and between the plunger 46 and the slider 76, respectively.

A positioning mechanism between the plunger 46 and the bottom 24 of the diaphragm portion 18 is not required, and the plunger 46 and the bottom 24 of the diaphragm portion 18 can be separated from each other. Further, the positioning mechanism is not limited to the fitting between the positioning projection 28 and the fitting hole 54. For example, the positioning mechanism may be configured by bonding, locking, fitting via other members, or the like.

The return spring 32 provided at the bottom portion 24 of the diaphragm portion 18 in the above embodiment is not essential. Furthermore, the return spring may be any element that exerts a backward force on the plunger 46 and may be provided separately from the diaphragm portion 18 . For example, if the plunger 46 is provided with an elastically deformable protrusion and the return spring is constituted by the protrusion, the plunger 46 is provided with the return spring.

In the above-described embodiment, the inner peripheral portion of the bottom portion 24 of the diaphragm portion 18 is thicker than the outer peripheral portion, but the entire bottom portion 24 may have a substantially constant thickness. Further, for example, the bottom portion 24 and the peripheral wall portion of the diaphragm portion 18 may have substantially constant thickness.

The movable member 92 is not limited to a specific shape as long as it constitutes a lock mechanism that regulates the movement of the push button 62 due to the pressing operation. Further, the sliding direction of the movable member 92 is not limited to the direction strictly orthogonal to the reciprocating direction of the push button 62, and may be inclined with respect to the orthogonal direction. Alternatively, the movable member 92 can be swung or rotated around a support shaft that is parallel to the pressing direction of the push button 62 and is set outside the movement path of the pressing operation of the push button 62. After assembly, the movable member may slide into the movement path of the push button 62 from the side by rocking or turning.

Further, the guide portion that guides the movable member is not limited to the guide tube portion 102 as in the embodiment, and for example, a guide projection that partially surrounds and guides the movable member, or a guide that penetrates the movable member. Various guides can be employed, such as a guide rod that guides the movable member. Of course, when employing a movable member that swings or rotates around a support shaft as described above, a separate guide portion is not necessarily required.

In the above-described embodiment, the portion of the push button 62 that abuts against the movable member 92 (locking claw portion 94) is constituted by the lock portion 72 projecting from the cylindrical peripheral wall portion of the push button 62 to the outer peripheral surface. However, the movable member 92 may be brought into direct contact with the cylindrical peripheral wall portion of the push button 62 without providing the locking portion 72 . By adopting such a lock portion 72, it is possible to form a contact portion with the movable member 92 while avoiding the influence on the shape and structure of the push button 62 itself, or to push the projecting position of the lock portion 72. There is an advantage that the length direction of the button 62 can be arbitrarily set.

Furthermore, in the above-described embodiment, the unlocking member is constituted by the projecting portion 58b projecting from the outer peripheral surface of the plunger 46, and the locking portion 72 projecting from the outer peripheral surface of the push button 62 and the corresponding The projecting portion 58b acts on both sides of the locking claw portion 94 of the movable member 92 disposed on the outer periphery of the peripheral wall portion of the push button 62 and the plunger 46, thereby locking (preventing the pressing operation) and unlocking. , compactness can be realized by the mechanism. Of course, the unlocking mechanism is not limited to the projecting portion 58b projecting from the outer peripheral surface of the plunger 46 as described above.
In addition, the present invention originally includes all of the inventions described in (i) to (xiii) below, and the configuration and effects thereof will be additionally noted.
The present invention
(i) A pressing operation member for executing rapid drug solution administration is reciprocably assembled in a housing that accommodates the sub-reservoir, and a lock mechanism is provided to restrict movement of the pressing operation member due to the pressing operation, A liquid injection controller comprising a lock release mechanism that releases the movement restriction of the pressing operation member by the lock mechanism when the sub-reservoir is filled with the liquid medicine;
(ii) A plunger is provided that presses the sub-reservoir by pressing operation of the pressing operation member to discharge the liquid medicine, and the pressing operation member and the plunger are disposed between the pressing operation member and the plunger. The liquid injection controller according to (i), wherein a displaceable slider is provided;
(iii) A plunger is provided that presses the sub-reservoir and discharges the liquid medicine by pressing operation of the pressing operation member, and a first spring and a second spring that exert a spring force between the plunger and the pressing operation member. The liquid injection controller according to (i) or (ii), which is provided with a spring;
(iv) the liquid injection controller according to (iii), wherein the first spring and the second spring have different spring constants;
(v) In the chemical injection controller described in (ii), the first spring and the second spring having different spring constants described in (iv) are employed, and the pressure operation member and the slider are arranged between the pressing member and the slider. and the second spring having a spring constant smaller than that of the first spring is arranged between the slider and the plunger,
(vi) A guide member is provided for guiding, in the reciprocating direction of the pressing operation member, a plunger that presses the sub-reservoir and discharges the liquid medicine by the pressing operation of the pressing operation member. The chemical injection controller according to any one of the items,
(vii) A locking pawl is provided that is locked to the pressed operating member and holds the pressing operating member in the pushed position, and the locking is performed when the chemical liquid is discharged from the sub-reservoir. An unlocking portion is provided for exerting a pressing force on the claw to release the locking of the locking claw from the pressing operation member, and the pressing force exerted on the locking claw from the unlocking portion. The chemical injection controller according to any one of (i) to (vi), which is provided with a return spring that reduces
(viii) A plunger is provided for discharging the chemical solution in the sub-reservoir by pressing operation of the pressing operation member, and a positioning mechanism is provided for positioning the sub-reservoir and the plunger relative to each other (i)- the liquid injection controller according to any one of (vii);
(ix) A housing containing a sub-reservoir is reciprocably assembled with a pressing operation member for performing rapid administration of a liquid medicine, and slides from the side onto a movement path by pressing operation of the pressing operation member. a liquid injection controller, wherein a movable member for regulating the movement of the pressing member in the pressing direction is provided in an independent state not connected to the pressing member;
(x) The liquid injection controller according to (ix), wherein the movable member enters onto the movement path of the pressing operation member from an outside position entirely removed from the movement path of the pressing operation member;
(xi) The liquid injection controller according to (ix) or (x), wherein the movable member is assembled so as to be able to reciprocate while being guided by a guide portion provided in the housing;
(xii) The liquid medicine according to any one of (ix) to (xi), further comprising an urging means for urging the movable member in a direction in which the movable member enters the moving path in the pressing direction of the pressing member. injection controller,
(xiii) The movable member is provided with a locking protrusion projecting toward the pressing operation member, and the pressing operation is performed when the pressing operation member comes into contact with one side surface of the locking protrusion. The movement of the member in the pressing direction is restricted, and the unlocking member that moves along with the filling of the sub-reservoir with the liquid medicine comes into contact with the other side surface of the lock protrusion. The liquid injection controller according to any one of (ix) to (xii), wherein the restriction on movement of the pressing member in the pressing direction by the movable member is released by
including inventions related to
In the invention described in (i) above, for example, after the patient presses the pressing member to rapidly administer the drug solution, the movement of the pressing member in the pressing direction is restricted by the lock mechanism. As a result, it is possible to prevent re-administration of the drug solution before the sub-reservoir is filled with a predetermined amount of the drug solution, which facilitates management of the dose of the drug solution. Excessive administration can also be prevented. When the sub-reservoir is filled with a predetermined amount of liquid medicine, the unlocking mechanism releases the movement restriction of the pressing member by the locking mechanism. This makes it possible to press the pressing member again. In this way, when the sub-reservoir is filled with a predetermined amount of liquid medicine, rapid administration of the liquid medicine by the patient's own operation is allowed. Therefore, administration of a predetermined amount at intervals of a predetermined time or more is realized, and the effect of the liquid medicine can be obtained effectively, and safety against self-administered drug administration can be improved.
In the invention described in (ii) above, for example, by appropriately changing the relative positions of the pressing member, the plunger, and the slider, it is possible to vary the pressing force exerted by the plunger on the sub-reservoir. Specifically, for example, the sub-reservoir is effectively pressed by integrally moving the slider and the plunger when the pressing operation member is pushed. When the pressing member returns from the pushed position to the initial position, the slider moves away from the plunger, thereby reducing or canceling the pushing direction force exerted on the plunger, and the pressing force exerted on the sub-reservoir. is reduced or eliminated. Further, for example, by guiding the pressing operation member and the plunger by the slider, the displacement of the pressing operation member and the plunger can be stabilized. Alternatively, by guiding the pressing operation member and the plunger via a movable slider, it is possible to divide the guide mechanism in the axial direction and configure it, for example, to increase the amount of movable stroke.
In the invention described in (iii) above, when the pressing operation member is pushed in the direction toward the plunger, the first spring and the second spring are compressed between the pressing operation member and the plunger, and the plunger moves toward the first spring. and is gradually pushed in by the elasticity of the second spring. As a result, the drug solution in the sub-reservoir can be efficiently pushed out, and excessive pressure can be prevented from acting on the sub-reservoir. Furthermore, by disposing two springs between the pressing operation member and the plunger, it is possible to obtain a large degree of freedom in adjusting the characteristics. For example, the lengths of the first spring and the second spring are different from each other, so that when the pressing member is pushed in, only the first spring is compressed halfway, and the first spring and the second spring are compressed halfway. If both are compressed, it is possible to change the response of the pressing operation during the pressing operation of the pressing operation member.
In the invention described in (iv) above, characteristics such as response when the pressing operation member is pressed can be adjusted with a greater degree of freedom.
In the invention described in (v) above, the first spring and the second spring are arranged in series between the pressing member and the plunger via the slider, so that each spring characteristic of the first spring and the second spring is is adjusted, it is possible to set, with a large degree of freedom, the feeling of operation when the pressing operation member is pressed. For example, when the pressing operation member is pressed, a large pressing force based on the elasticity of the first spring is exerted on the sub-reservoir from the plunger, and a small pressing force based on the elasticity of the second spring is applied to the sub-reservoir after the liquid medicine is discharged. be affected. As a result, both efficient discharge of the chemical solution from the sub-reservoir and efficient filling of the sub-reservoir with the chemical solution are achieved.
In the invention described in (vi) above, when the plunger is moved by the pressing operation of the pressing operation member, the plunger is guided by the guide member, thereby preventing inclination of the plunger and achieving stable operation. .
In the invention described in (vii) above, for example, even when the pressing force is continuously applied from the unlocking portion to the locking pawl, the pressing force exerted from the unlocking portion to the locking pawl by the return spring is reduced. reduced to prevent plastic deformation of the pawl.
In the invention described in (viii) above, for example, the plunger appropriately presses the sub-reservoir, thereby stabilizing the deformation of the sub-reservoir. Therefore, the chemical solution is stably discharged from the sub-reservoir, and the sub-reservoir is stably filled with the chemical solution.
In the invention described in (ix) above, since the movable member for blocking the pressing operation of the pressing operation member is provided, for example, by appropriately setting conditions for canceling the blocking of the pressing operation by the movable member, the drug solution by the patient can be It becomes possible to avoid overdosing of Moreover, since the movable member slides into the moving path of the pressing operation member from the side, it is possible to arrange the movable member in a smaller space than in the swing mechanism. It also becomes easier to secure the allowable stroke. In addition, since the movable member is provided in an independent state without being connected to the pressing operation member via a link mechanism or the like, adverse effects on the pressing operation of the pressing operation member are avoided, and the mechanism becomes complicated. can also be reduced.
In the invention described in (x) above, when the pressing operation of the pressing operation member is not blocked, the movable member is completely deviated from the moving path of the pressing operation member, and the pressing operation of the pressing operation member is performed more stably. It becomes possible.
In the invention described in (xi) above, the movable member is guided by, for example, a wall-shaped guide portion that surrounds the entire circumference or partially surrounds the circumference. Therefore, tilting of the movable member can be suppressed, and the stroke stability of the movable member can be improved.
In the invention described in (xii) above, the pressing operation blocking state of the pressing operation member can be easily and stably maintained by the positioning action of the movable member by the biasing force of the biasing means.
In the invention described in (xiii) above, since the pressing operation of the pressing operation member can be regulated by the lock projection partly protruding from the movable member, the main body portion of the movable member that is larger than the lock projection can be used during movement. Stability can be ensured, and movement restrictions of the pressing operation member can be released using the lock projection. can also be kept small.

10 chemical injection controller 12 housing 14 sub-reservoir 16 gripping surface 18 diaphragm portion 20 base member 22 clamping portion 24 bottom portion 28 positioning protrusion (positioning mechanism)
30 tapered portion 32 return spring 34 chemical inflow portion 36 chemical outflow portion 38 engagement protrusion 40 guide member 42 engagement portion 44 locking hook (locking claw)
46 plunger 48 plunger main body 50 outer peripheral guide portion 52 recess 54 fitting hole (positioning mechanism)
56 Unlocking portion 58a (upper) protrusion (mark)
58b (lower) protrusion (unlock mechanism)
60 Inclined surface 62 Push button (press operation member)
64 pressing operation surface 66 spring supporting portion 68 slider engaging hole 70 hook engaging hole 72 locking portion 74 main moving piece 76 slider 78 central portion 80 outer cylindrical portion 82 through hole 84 engaging projection 86 first coil spring (first spring)
88 second coil spring (second spring)
90 lock mechanism 92 movable member (lock mechanism)
94 locking pawl (lock projection)
96 inclined surface 98 spring insertion recess 100 guide projection 102 guide tube portion 104 guide groove 106 projection 108 groove 110 biasing member (lock mechanism)
112 Inflow channel 114 Outflow channel 116 Shut-off valve 118 Rapid dosing valve 120 Restricted channel 122 Flow controller 124 Upstream external line 126 Downstream external line 128 Main line 130 Subline 134 Switch member 136 Follower piece 138 Coil spring 140 slit

Claims (9)

A pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates the sub-reservoir,
a lock mechanism provided on the housing side and having a movable member that restricts the movement of the pressing operation member due to the pressing operation by entering from the side onto the moving path of the pressing operation member;
a lock release mechanism for releasing the movement restriction of the pressing member by the locking mechanism by releasing the movable member laterally from the movement path of the pressing member when the sub-reservoir is filled with the chemical solution; chemical dosing controller. A pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates the sub-reservoir,
A lock mechanism for restricting movement of the pressing operation member by the pressing operation is provided, and
a lock release mechanism that releases movement restriction of the pressing member by the lock mechanism when the sub-reservoir is filled with the chemical solution; and
A plunger is provided that presses the sub-reservoir and discharges the liquid medicine by pressing operation of the pressing operation member, and a slider is provided between the pressing operation member and the plunger and is relatively displaceable with respect to the pressing operation member and the plunger. is provided, and
A first spring and a second spring having different spring constants and exerting a spring force between the plunger and the pressing member are employed, and the first spring is arranged between the pressing member and the slider. and the second spring having a spring constant smaller than that of the first spring is arranged between the slider and the plunger. A pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates the sub-reservoir,
A lock mechanism for restricting movement of the pressing operation member by the pressing operation is provided, and
a lock release mechanism that releases movement restriction of the pressing member by the lock mechanism when the sub-reservoir is filled with the chemical solution; and
A liquid injection controller provided with a guide member for guiding, in a reciprocating direction of the pushing operation member, a plunger that compresses the sub-reservoir and discharges the liquid medicine by pushing operation of the pushing operation member. A pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates the sub-reservoir,
A lock mechanism for restricting movement of the pressing operation member by the pressing operation is provided, and
a lock release mechanism that releases movement restriction of the pressing member by the lock mechanism when the sub-reservoir is filled with the chemical solution; and
A locking pawl is provided that is locked to the pressed pressing member and holds the pressing member in the pushed position, and the locking pawl is pressed when the chemical liquid is discharged from the sub-reservoir. An unlocking portion that applies pressure to release the locking of the locking claw from the pressing member is provided, and further reduces the pressing force exerted on the locking claw from the unlocking portion. A dosing controller provided with a return spring . A pressing operation member for performing rapid drug solution administration is reciprocally assembled in a housing that accommodates the sub-reservoir,
A movable member that restricts the movement of the pressing member in the pressing direction by sliding from the side onto the moving path of the pressing member due to the pressing operation is an independent member that is not connected to the pressing member. A dosing controller provided in the state. 6. The liquid injection controller according to claim 5 , wherein the movable member enters onto the movement path of the pressing operation member from an outer position where the entirety is out of the movement path of the pressing operation member. 7. The liquid injection controller according to claim 5 , wherein said movable member is assembled so as to be able to reciprocate while being guided by a guide portion provided in said housing. 8. The liquid injection controller according to any one of claims 5 to 7 , further comprising biasing means for biasing the movable member in a direction in which the movable member enters a moving path in a pressing direction of the pressing member. The movable member is provided with a locking projection projecting toward the pressing operation member,
Movement of the pressing member in the pressing direction is restricted by contact of the pressing member with one side surface of the lock projection,
When the unlocking member, which moves as the sub-reservoir is filled with the liquid medicine, comes into contact with the other side surface of the lock protrusion, the restriction on movement of the pressing member in the pressing direction by the movable member is released. The liquid injection controller according to any one of claims 5 to 8 , wherein the liquid injection controller is adapted to be

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