JP7272968B2 - 細胞培養および組織再生のための足場 - Google Patents

細胞培養および組織再生のための足場 Download PDF

Info

Publication number
JP7272968B2
JP7272968B2 JP2019569953A JP2019569953A JP7272968B2 JP 7272968 B2 JP7272968 B2 JP 7272968B2 JP 2019569953 A JP2019569953 A JP 2019569953A JP 2019569953 A JP2019569953 A JP 2019569953A JP 7272968 B2 JP7272968 B2 JP 7272968B2
Authority
JP
Japan
Prior art keywords
scaffold
scaffolds
aligned
solution
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019569953A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020524033A (ja
JP2020524033A5 (enExample
Inventor
ファン リンペン
リー ジンリアン
ワン シャンハイ
Original Assignee
ディーキン ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2017902326A external-priority patent/AU2017902326A0/en
Application filed by ディーキン ユニバーシティ filed Critical ディーキン ユニバーシティ
Publication of JP2020524033A publication Critical patent/JP2020524033A/ja
Publication of JP2020524033A5 publication Critical patent/JP2020524033A5/ja
Priority to JP2023038285A priority Critical patent/JP7565399B2/ja
Application granted granted Critical
Publication of JP7272968B2 publication Critical patent/JP7272968B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019569953A 2017-06-19 2018-06-14 細胞培養および組織再生のための足場 Active JP7272968B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023038285A JP7565399B2 (ja) 2017-06-19 2023-03-13 多孔性生体模倣足場、バイオメディカルインプラントおよびそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2017902326A AU2017902326A0 (en) 2017-06-19 Scaffolds for cell culture and tissue regeneration
AU2017902326 2017-06-19
PCT/AU2018/050592 WO2018232445A1 (en) 2017-06-19 2018-06-14 SCAFFOLDS FOR CELL CULTURE AND REGENERATION OF FABRICS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023038285A Division JP7565399B2 (ja) 2017-06-19 2023-03-13 多孔性生体模倣足場、バイオメディカルインプラントおよびそれらの使用

Publications (3)

Publication Number Publication Date
JP2020524033A JP2020524033A (ja) 2020-08-13
JP2020524033A5 JP2020524033A5 (enExample) 2021-04-15
JP7272968B2 true JP7272968B2 (ja) 2023-05-12

Family

ID=64735388

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019569953A Active JP7272968B2 (ja) 2017-06-19 2018-06-14 細胞培養および組織再生のための足場
JP2023038285A Active JP7565399B2 (ja) 2017-06-19 2023-03-13 多孔性生体模倣足場、バイオメディカルインプラントおよびそれらの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023038285A Active JP7565399B2 (ja) 2017-06-19 2023-03-13 多孔性生体模倣足場、バイオメディカルインプラントおよびそれらの使用

Country Status (7)

Country Link
US (1) US20200171208A1 (enExample)
EP (1) EP3641840A4 (enExample)
JP (2) JP7272968B2 (enExample)
CN (2) CN116421788A (enExample)
AU (1) AU2018286644B2 (enExample)
CA (1) CA3065194A1 (enExample)
WO (1) WO2018232445A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018152149A1 (en) 2017-02-17 2018-08-23 The Research Foundation For The State University Of New York High-flux thin-film nanocomposite reverse osmosis membrane for desalination
JP7256536B2 (ja) * 2019-07-26 2023-04-12 株式会社Met 処置訓練用の模擬体、処置訓練用の模擬体の評価方法および処置訓練用の模擬体の製造方法
AU2020398712A1 (en) * 2019-12-06 2022-07-14 Trustees Of Tufts College Tissue regenerative multi-drug cocktail and apparatus for delivery thereof
CN111657267B (zh) * 2020-06-17 2021-02-02 科瑞百奥泰州生物技术有限公司 一种用于软骨，肌腱，半月板保存的无冰晶冷冻保存液和冷冻方法
CN112920452B (zh) * 2021-03-18 2022-11-15 吉林大学第一医院 增材制造的多孔聚醚醚酮支架及生物活性改善方法和应用
US11912972B2 (en) * 2022-04-25 2024-02-27 Ark Biotech Inc. Scaffold bioreactor
WO2025055408A1 (zh) * 2023-09-14 2025-03-20 杭州印生医疗科技有限公司 一种修复膜及其制备方法
CN120796173B (zh) * 2025-09-10 2025-12-02 上海大学 一种磁场辅助构建有序结构类皮肤组织的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072937A1 (fr) 2001-03-14 2002-09-19 Japan As Represented By President Of Tokyo University Of Agriculture And Technology Tissu non tisse contenant une fibre ultra-fine de fibroine de soie et/ou de materiau similaire a la soie, et procede de fabrication correspondant
JP2011521020A (ja) 2008-04-30 2011-07-21 オルソックスリミテッド 移植可能な材料およびその調製方法
US20140222152A1 (en) 2013-02-06 2014-08-07 Tufts University Implantable intervertebral disc devices and uses thereof
US20170027879A1 (en) 2011-11-08 2017-02-02 Tufts University Silk-based scaffold platform for engineering tissue constructs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19751031A1 (de) * 1997-11-19 1999-06-24 Ingo Dipl Ing Heschel Verfahren zur Herstellung poröser Strukturen
CN101500508A (zh) * 2006-06-09 2009-08-05 加利福尼亚大学董事会 生物分子连接的仿生支架
WO2010127119A2 (en) * 2009-04-29 2010-11-04 The Regents Of The University Of Michigan Multiphasic microfibers for spatially guided cell growth
CN101810878B (zh) * 2010-05-14 2013-05-01 中山大学 具有多级孔结构的纳米纤维管状支架
CN103820943B (zh) * 2014-03-11 2016-04-13 武汉大学 大孔三维有序取向性丝素蛋白纳米纤维支架及其制备方法
CN106110396A (zh) * 2016-05-18 2016-11-16 江苏工程职业技术学院 一种含有微通道和取向纳米纤维的神经导管及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072937A1 (fr) 2001-03-14 2002-09-19 Japan As Represented By President Of Tokyo University Of Agriculture And Technology Tissu non tisse contenant une fibre ultra-fine de fibroine de soie et/ou de materiau similaire a la soie, et procede de fabrication correspondant
JP2011521020A (ja) 2008-04-30 2011-07-21 オルソックスリミテッド 移植可能な材料およびその調製方法
US20170027879A1 (en) 2011-11-08 2017-02-02 Tufts University Silk-based scaffold platform for engineering tissue constructs
US20140222152A1 (en) 2013-02-06 2014-08-07 Tufts University Implantable intervertebral disc devices and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ACS Biomater Sci Eng，2016年04月11日，2(4)，643-651
Yiling Huang，"Fabrication of 3D Ultrafine Fibrous Protein Structures via Freeze-Drying"，DigitalCommons@University of Nebraska - Lincoln，2014年，[online] [2021年10月15日検索]＜URL:https://digitalcommons.unl.edu/textilesdiss/5/＞
福岡県工業技術センター研究報告，2014年，No.24，1-4

Also Published As

Publication number Publication date
EP3641840A4 (en) 2021-03-17
JP7565399B2 (ja) 2024-10-10
JP2020524033A (ja) 2020-08-13
CN116421788A (zh) 2023-07-14
AU2018286644A1 (en) 2019-12-19
AU2018286644B2 (en) 2024-04-11
CN110944682A (zh) 2020-03-31
CN110944682B (zh) 2023-08-08
CA3065194A1 (en) 2018-12-27
NZ759571A (en) 2025-07-25
US20200171208A1 (en) 2020-06-04
EP3641840A1 (en) 2020-04-29
JP2023072017A (ja) 2023-05-23
WO2018232445A1 (en) 2018-12-27

Similar Documents

Publication Publication Date Title
JP7565399B2 (ja) 多孔性生体模倣足場、バイオメディカルインプラントおよびそれらの使用
Muthukrishnan An overview on electrospinning and its advancement toward hard and soft tissue engineering applications
Yao et al. Novel bilayer wound dressing based on electrospun gelatin/keratin nanofibrous mats for skin wound repair
Nemati et al. Current progress in application of polymeric nanofibers to tissue engineering
Liu et al. Progress in electrospun fibers for manipulating cell behaviors
AU2021204269B2 (en) Nanofiber structures and methods of synthesis and use thereof
Ayres et al. Nanotechnology in the design of soft tissue scaffolds: innovations in structure and function
Xiao et al. A radial 3D polycaprolactone nanofiber scaffold modified by biomineralization and silk fibroin coating promote bone regeneration in vivo
Zhang et al. Silk fibroin/sodium alginate composite nano-fibrous scaffold prepared through thermally induced phase-separation (TIPS) method for biomedical applications
Gao et al. 3D-printing of solvent exchange deposition modeling (SEDM) for a bilayered flexible skin substitute of poly (lactide-co-glycolide) with bioorthogonally engineered EGF
Babu et al. Controlling structure with injectable biomaterials to better mimic tissue heterogeneity and anisotropy
Lee et al. Development of artificial dermis using 3D electrospun silk fibroin nanofiber matrix
EP2897659B1 (en) New scaffold for cardiac patch
Liu et al. Flexible water-absorbing silk-fibroin biomaterial sponges with unique pore structure for tissue engineering
Preethi et al. Biomedical applications of natural polymer based nanofibrous scaffolds
Lv et al. Preparation and characterization of PLA/fibroin composite and culture of HepG2 (human hepatocellular liver carcinoma cell line) cells
Menezes et al. Effect of crosslinking, hydroxyapatite addition, and fiber alignment to stimulate human mesenchymal stem cells osteoinduction in polycaprolactone‐based electrospun scaffolds
Chae et al. Electrospun nanofibrous tissue scaffolds
Sathish et al. Nano, micro, and macro materials in scaffolds for biomedical applications: a review
Shi et al. Fibrous scaffolds for tissue engineering
Biazar et al. Nanotechnology for peripheral nerve regeneration
Ramar et al. Preparation and characterization of hybrid nanofibrous polymer scaffolds for tissue engineering applications
Sánchez-Téllez Biological hyaluronic-acid based and chondroitin sulfate-based hybrids hydrogels with great potential for cartilage substitution and regeneration
Mohammadzadehmoghadam Electrospun Silk Nanofibre Mats and Their Potential as Tissue Scaffolds
Yao Advanced Nanofibrous Scaffolds to Influence Endothelial Cell Activity: Towards Improved Strategies for Vascularized Tissue Regeneration

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210302

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210302

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20211022

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211026

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220531

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220824

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230313

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230404

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230427

R150 Certificate of patent or registration of utility model

Ref document number: 7272968

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150