JP7271255B2 - How to measure the amount of skin sagging - Google Patents

How to measure the amount of skin sagging Download PDF

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JP7271255B2
JP7271255B2 JP2019063072A JP2019063072A JP7271255B2 JP 7271255 B2 JP7271255 B2 JP 7271255B2 JP 2019063072 A JP2019063072 A JP 2019063072A JP 2019063072 A JP2019063072 A JP 2019063072A JP 7271255 B2 JP7271255 B2 JP 7271255B2
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かおり 松ヶ下
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Naris Cosmetics Co Ltd
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Description

本発明は、皮膚たるみ量の測定方法に関する。 The present invention relates to a method for measuring the amount of skin sagging.

皮膚のたるみは、多くの人の関心の高い肌の老化現象のひとつである。顔面のたるみの原因は、年齢や真皮のコラーゲン量、皮膚の弾力性や皮下脂肪厚など皮膚の物性の増減が起因しているといわれている。例えば、たるみと弾力性、たるみと皮下脂肪との関係は明らかとなっている(非特許文献1、2)が、それら皮膚物性の変化が実際の皮膚表面において、それぞれどのような変化をもたらすのかは知られていない。 Sagging skin is one of the aging phenomena of the skin that many people are concerned about. Sagging of the face is said to be caused by changes in the physical properties of the skin, such as age, the amount of collagen in the dermis, the elasticity of the skin, and the thickness of the subcutaneous fat. For example, the relationships between sagging and elasticity and between sagging and subcutaneous fat have been clarified (Non-Patent Documents 1 and 2). is not known.

皮膚のたるみを改善する方法として、エステティックやマッサージなどの美容施術、補正下着に代表される物理的方法や、医薬品、化粧品、サプリメントなどによる化学的方法、またこれを組み合わせた方法が試みられている。 Attempts have been made to improve the sagging of the skin by beauty treatments such as esthetics and massages, physical methods represented by corrective underwear, chemical methods using pharmaceuticals, cosmetics, supplements, etc., and methods in which these methods are combined. there is

それらの改善効果を確かめるにあたっては、これまで様々な方法が利用されており、例えば、美容施術前後の皮下脂肪厚や皮下血流量を計測する方法(特許文献1)や、コラーゲンの強度を動的粘弾性試験などにより評価する方法(特許文献2)が知られている。
しかしながら、たるみを目視によるスコア化して評価する方法では、たるみの微差を捉えることができず、またほうれい線などの変化が目立つ部分以外の評価が困難である。また、これらの方法では、顔面がたるんでいるという現象は確認できるが、そのたるみが何に起因しているかを明確にするまでには至らない。
Various methods have been used to confirm these improvement effects. A method of evaluation by a viscoelasticity test or the like is known (Patent Document 2).
However, the method of visually scoring and evaluating sagging cannot capture minute differences in sagging, and it is difficult to evaluate areas other than those where changes such as nasolabial folds are conspicuous. Moreover, although these methods can confirm the phenomenon that the face is sagging, they do not lead to clarifying what is causing the sagging.

一方で、画像などを用いた評価方法として、顔の基準点及び測定点にマーキングを施し、水平位と垂直位顔写真を撮影し、基準点からのマークの移動距離を皮膚の垂直軸方向成分の相対距離値に演算することで皮膚のたるみ量を算出する方法(特許文献3)が知られている。
しかしながら、把握されるたるみ量は、測定点における垂直方向への変化に留まり、測定点を含む周囲の多方向への変化を把握するものではない。
On the other hand, as an evaluation method using images, marks are applied to the reference points and measurement points on the face, horizontal and vertical facial photographs are taken, and the moving distance of the mark from the reference point is measured as the vertical component of the skin. There is known a method (Patent Document 3) of calculating the amount of skin sagging by calculating the relative distance value of .
However, the grasped amount of slack is limited to changes in the vertical direction at the measurement point, and does not grasp changes in the surroundings including the measurement point in multiple directions.

これに対し、目盛り付きシールを測定客体として、測定点に貼り付け撮影、解析することより、たるむ方向を把握する試みがされている(特許文献4)が、年齢や体格との関係や、たるむ方向の意義や、皮膚の状態や変化との関係については述べられていない。 On the other hand, an attempt has been made to grasp the direction of sagging by using a sticker with a scale as a measurement object, sticking it to the measurement point, photographing it, and analyzing it (Patent Document 4). The significance of direction and its relation to skin conditions and changes are not stated.

皮膚のたるみと衝撃波の伝搬時間との相関関係に基づき皮膚のたるみ度合いを推定する方法が知られている(特許文献5)。しかしながら、たるみ度合いを計測するには、衝撃波伝搬測定装置が必要であり、決して簡便な方法とは言えないし、たるみと衝撃波以外との関係は不明である。 A method of estimating the degree of skin sagging based on the correlation between skin sagging and shock wave propagation time is known (Patent Document 5). However, measuring the degree of sagging requires a shock wave propagation measuring device, which cannot be said to be a simple method, and the relationship between sagging and anything other than the shock wave is unknown.

測定対象の表面を直接的に測定する方法としては、サンプリングモアレカメラ等を用いて、三次元的に垂直位の顔を撮影し、解析する方法(以下、モアレ法)や、3Dスキャナを用いて評価する方法が知られている。しかしながら、モアレ法はサンプリングモアレカメラによる正確な撮影のため、準暗室にて頭部の固定化等被験者のストレスが強く、簡便さに欠けたり、スポット的な解析には好ましくない。また、3Dスキャナを用いる方法では、局所のたるみ全体を把握するのは適しているが、検出限界が大きく、スポット的な測定には適していない。 As a method of directly measuring the surface of the object to be measured, a sampling moire camera or the like is used to photograph and analyze the face in a three-dimensional vertical position (hereinafter referred to as the moire method), or a 3D scanner is used. There are known methods of evaluation. However, since the moire method is an accurate imaging with a sampling moire camera, the stress of the subject such as fixation of the head in a semi-dark room is strong, and it lacks convenience and is not preferable for spot analysis. Also, the method using a 3D scanner is suitable for grasping the entire local sagging, but has a large detection limit and is not suitable for spot measurement.

このように、たるみ量を把握する方法は種々提案されているが、いずれの方法によっても、たるみの程度は把握できるものの、皮膚表面上の変化を皮膚の物性変化と関連づけて、簡便に確認する測定方法は存在していない現状にある。 As described above, various methods for grasping the amount of sagging have been proposed, but although the degree of sagging can be grasped by any method, changes on the skin surface are associated with changes in physical properties of the skin for easy confirmation. Currently there is no measuring method.

Tomonobu Ezure,Sagging of the cheek is related to skin elasticity,fat mass and mimetic muscle function:Skin Res Technol.,Aug;15(3):299-305,2009Tomonobu Ezure, Sagging of the cheek is related to skin elasticity, fat mass and mimetic muscle function: Skin Res Technol. , Aug;15(3):299-305, 2009 Tomonobu Ezure,Involvement of upper cheek sagging in nasolabial fold formation.:Skin Res. Technol.,18:259-264,2012.Tomonobu Ezure, Involvement of upper check sagging in nasolabial fold formation. : Skin Res. Technol. , 18:259-264, 2012.

特開2010-51717号公報JP 2010-51717 A 特開平10-95713号公報JP-A-10-95713 特開平10-43141号公報JP-A-10-43141 特開2014-4105号公報Japanese Patent Application Laid-Open No. 2014-4105 特開2011-15862号公報JP 2011-15862 A

本発明は、皮膚のたるみ量をより簡便な方法で三次元的に評価可能な技術を提供することを課題とする。 An object of the present invention is to provide a technique capable of three-dimensionally evaluating the amount of skin sagging by a simpler method.

本発明者は、たるみを直接的に測定したり、微差を捉えることが容易ではなく、また測定部位に制約があり、被験者への負荷が大きかった従来技術での問題点を改良すべく、鋭意研究した。検討の結果、水平位、垂直位の二姿勢の画像を重ね合わせて解析することで皮膚のたるみ度を評価する方法において、測定点に加えて、測定点の周囲に、皮膚の形状の変化に伴って変形可能なマーキングを施したところ、測定点の移動(変位距離)以外に、測定点の移動する方向(変位方向)、測定点の周囲の皮膚の動きが、被験者によって大きく異なることを発見した。そこでこの違いを把握すべく、各種分析を行ったところ、水平位、垂直位の二姿勢の画像を重ね合わせた際に得られる測定点の変位距離、測定点の変位前後位置を結ぶ線と変位後の点を通る水平線とがなす角度(変位角)、及びマーキングの形状変化等を解析することで、より簡便かつ直接的に皮膚のたるみ量等を測定することが可能になることを見出した。
すなわち、本発明は、
〔1〕第1発明としては、
水平位皮膚表面画像と垂直位皮膚表面画像を重ねることで、皮膚のたるみ量を測定する方法において、
測定点から任意の距離を隔てた外周に、皮膚の形状変化に伴って変形可能な囲み部を設けるステップ
を含む皮膚たるみ量の測定方法である。
〔2〕第2発明としては、
皮膚のたるみ量を測定する方法において
(1) 被験者の皮膚に基準点を設けるステップ
(2) 基準点とは異なる点を測定点とするステップ
(3) 測定点から任意の距離を隔てた外周に、皮膚の形状変化に伴って変形可能な囲み部を設けるステップ
(4) 被験者を仰臥位で、少なくとも基準点、測定点を含む状態で、水平位の皮膚表面を撮像するステップ
(5) 被験者を座位又は立位で、少なくとも基準点、測定点を含む状態で、垂直位の皮膚表面を撮像するステップ
(6) ステップ(4)、(5)で得られた画像から次の少なくとも1つを測定するステップ
(a-1)変位距離
(a-2)変位方向
(a-3)変位角
(a-4)方位角
(a-5)長短比
(a-6)面積
を含む皮膚たるみ量の測定方法である。
〔3〕第3発明としては、
前記ステップ(6)において、前記ステップ(4)、前記ステップ(5)で得られた画像から、次の少なくとも1つを測定し、垂直位で得られた値と、水平位で得られた値との変化量を得るステップを含む第2発明に記載の測定方法である。
(a-4)方位角
(a-5)長短比
(a-6)面積
〔4〕第4発明としては
第2発明又は第3発明に記載の方法で皮膚のたるみ量を測定し、得られた結果からたるみの原因を判定する方法である。
〔5〕第5発明としては、
第2発明又は第3発明記載の方法で皮膚のたるみ量を測定し、得られた結果からたるみの原因を判定し、原因に対応する商品及び/又はサービスを提供する方法である。
〔6〕発明としては、
第1発明乃至第3発明に記載の方法に用いられる装置
である。
In order to improve the problems of the prior art, it was not easy to directly measure the slackness or capture the slight difference, and there were restrictions on the measurement site, and the burden on the subject was large. studied diligently. As a result of the study, in the method of evaluating the degree of skin sagging by superimposing and analyzing images of two postures of horizontal and vertical positions, in addition to the measurement points, around the measurement points, it was found that changes in skin shape When a deformable marking was applied along with it, it was discovered that the movement of the measurement point (displacement distance), the direction of movement of the measurement point (displacement direction), and the movement of the skin around the measurement point differed greatly depending on the subject. bottom. Therefore, in order to grasp this difference, various analyzes were conducted, and the displacement distance of the measurement point obtained when images of two postures, horizontal and vertical, were superimposed, and the line connecting the position before and after the displacement of the measurement point and the displacement By analyzing the angle (displacement angle) formed by the horizontal line that passes through the latter point and the shape change of the marking, it was found that it became possible to measure the amount of sagging of the skin more easily and directly. .
That is, the present invention
[1] As the first invention,
In the method of measuring the amount of skin sagging by overlapping a horizontal skin surface image and a vertical skin surface image,
A method for measuring the amount of skin sagging, including the step of providing an enclosing portion deformable in accordance with changes in the shape of the skin at an arbitrary distance from the measurement point.
[2] As the second invention,
In the method for measuring the amount of skin sagging, (1) the step of setting a reference point on the subject's skin, (2) the step of setting a point different from the reference point as the measurement point, and step (4) of providing an enclosing part that can be deformed according to the shape change of the skin; imaging the skin surface in a horizontal position with the subject in the supine position, including at least the reference point and the measurement point; Step (6) of taking an image of the skin surface in a vertical position in a sitting or standing position, including at least a reference point and a measurement point. Measure at least one of the following from the images obtained in steps (4) and (5). (a-1) Displacement distance (a-2) Displacement direction (a-3) Displacement angle (a-4) Azimuth angle (a-5) Length ratio (a-6) Measurement of skin sagging amount including area The method.
[3] As the third invention,
In the step (6), from the images obtained in the step (4) and the step (5), at least one of the following is measured, the value obtained in the vertical position and the value obtained in the horizontal position The measurement method according to the second invention, including the step of obtaining the amount of change from .
(a-4) Azimuth angle (a-5) Length ratio (a-6) Area This is a method for determining the cause of slack from the results obtained.
[5] As the fifth invention,
A method of measuring the amount of sagging of the skin by the method according to the second or third invention, determining the cause of sagging from the obtained results, and providing products and/or services corresponding to the cause.
[6] As an invention,
An apparatus used in the method according to the first to third inventions.

本発明の測定方法は、測定部位の凹凸を反映し、簡易かつ精度良く、皮膚のたるみ量を測定することができ、皮膚の物性変化との関係性を判定することもでき、化粧料等の効果を評価することができる。
例えば、美容施術の効果を確認したり、化粧品の長期使用における効果を評価したり、化粧品をどの部位に集中的に使用することで、より高い効果が得られるかなど、ユーザーに対する美容情報の提供に応用することも可能となる。
The measurement method of the present invention reflects the unevenness of the measurement site, can easily and accurately measure the amount of sagging of the skin, can determine the relationship with changes in physical properties of the skin, and can be applied to cosmetics and the like. effects can be evaluated.
For example, providing users with beauty information such as confirming the effects of beauty treatments, evaluating the effects of long-term use of cosmetics, and identifying areas where cosmetics should be used intensively for greater effects. It is also possible to apply to

さらに本発明の測定方法は、顔面全体をはじめ、目尻、まぶた、頬等の顔面の一部、二の腕、太ももなどの手足、胸部、腹部、臀部など、全身の皮膚を測定対象とすることができる。また、たるみに対する効果を評価する対象物としても、医薬品、医薬部外品、化粧品などの皮膚外用組成物に限らず、マッサージ、エステティックなどの美容施術や、たるみ解消を目的とした美容機器、サプリメント、下着など、たるみの評価を必要とする対象物全般に使用することができる。当然、人のみではなく、動物にも適用できる。
また、副次的効果として、たるみ量から皮膚内部状態を予測し、被験者に適した化粧品等の提供や、カウンセリングツールとして用いることが考えられる。
Furthermore, the measurement method of the present invention can be used to measure the skin of the whole body, such as the entire face, parts of the face such as the corners of the eyes, eyelids, and cheeks, limbs such as the upper arms and thighs, the chest, abdomen, and buttocks. . In addition, the target objects for evaluating the effect on sagging are not limited to external skin compositions such as pharmaceuticals, quasi-drugs, and cosmetics. It can be used for general objects that require evaluation of slackness, such as supplements and underwear. Naturally, it can be applied not only to humans but also to animals.
In addition, as a secondary effect, it is possible to predict the internal state of the skin from the amount of sagging, provide cosmetics suitable for the subject, and use it as a counseling tool.

測定点、囲み部、基準点、スケールの設定例Setting example of measurement point, enclosure, reference point, and scale 変位方向の説明図Illustration of displacement direction 変位角の説明図Illustration of displacement angle 方位角の説明図Illustration of azimuth angle 年齢と変位距離との関係Relationship between age and displacement distance 全身皮下脂肪率と変位距離との関係Relationship between whole body subcutaneous fat percentage and displacement distance 変位角と角層水分量との関係Relationship between displacement angle and stratum corneum water content 変位角とR7(弾力性)との関係Relationship between displacement angle and R7 (elasticity) 年齢と方位角変化率の関係Relationship between age and rate of azimuth change 角層水分量と方位角変化率との関係Relationship between stratum corneum moisture content and azimuth angle change rate コラーゲン密度と方位角変化率との関係Relationship between collagen density and rate of azimuthal angle change 全身皮下脂肪率と長短比変化率との関係Relationship between whole body subcutaneous fat percentage and length ratio change rate コラーゲン密度と長短比変化率との関係Relationship between collagen density and length ratio change rate 角層面積と長短比変化率との関係Relationship between stratum corneum area and length ratio change rate 年齢と長短比変化率との関係Relationship between age and long-term ratio change 全身皮下脂肪率と面積変化率との関係Relationship between whole body subcutaneous fat percentage and area change rate

本発明は、水平位と垂直位にて任意の測定点を含む部分を撮像し、得られた各像を重ね合わせ、測定点、及び/又は囲み部の位置、形態的変化を計測、評価することにより、たるみ量の計測、たるみの評価、たるみ改善度の評価、たるみ改善方法の提供、皮膚や身体の状態や変化等体内変化を推測し、判定する方法等を提供するものである。 The present invention captures an image of a portion including an arbitrary measurement point at horizontal and vertical positions, superimposes the obtained images, measures and evaluates the position of the measurement point and/or the surrounding portion, and morphological changes. Thus, the present invention provides methods for measuring the amount of sagging, evaluating sagging, evaluating the degree of improvement of sagging, providing methods for improving sagging, and estimating and judging internal changes such as skin and body conditions and changes.

本発明の基準点は、測定する部位の水平位、垂直位の変化を評価するにあたり、各位で得た像を適切に重ねる趣旨で設けるものである。従って、必ずしも基準点をマーキングする必要はなく、例えば、既にあるホクロや眉毛等を基準点とすることも差し支えない。基準点としてマーキングする場合は、姿勢を変化させた際に最も移動の少ない部位であることが好ましく、例えば、顔面部の皮膚のたるみ量を測定する場合の基準点としては、眉上、眉間、鼻根、鼻尖、人中、オトガイ、唇溝、目尻などが好ましい。胸部であれば、鎖骨、喉頭隆起(喉仏)、腹部であれば肋骨、臀部であれば、尾骨、仙骨等の外部から認識される点を基準点とすることができる。
基準点は、少なくとも1点あれば十分であるが、2点以上設けるとより正確にたるみを把握することができるので好ましい。
必須ではないが、スケールを撮像レンズ部と平行になるように設置すると、画像処理上での距離、面積計算が正確に行えるため、好ましい。顔面を評価する場合であれば、例えば額中央部に設けることができる。
The reference point of the present invention is provided for the purpose of appropriately superimposing the images obtained at each site when evaluating changes in the horizontal and vertical positions of the site to be measured. Therefore, it is not always necessary to mark the reference point, and for example, existing moles, eyebrows, etc. may be used as the reference point. When marking as a reference point, it is preferable that it is the part that moves the least when the posture is changed. The root of the nose, tip of the nose, philtrum, chin, labial groove, outer corner of the eye, etc. are preferred. For the chest, the clavicle and laryngeal protuberance (larynx), for the abdomen, the ribs, and for the buttocks, the coccyx, sacrum, and other externally recognized points can be used as reference points.
At least one reference point is sufficient, but it is preferable to provide two or more reference points because the slack can be grasped more accurately.
Although not essential, it is preferable to install the scale so as to be parallel to the image pickup lens unit, because the distance and area can be calculated accurately in image processing. If the face is to be evaluated, it can be provided, for example, in the center of the forehead.

本発明における測定点は、1ヶ所、2ヶ所以上、目的に応じて適宜設定できる。例えば、化粧品などの評価において、顔全体に塗布した場合、どの部位に特に効果が高いかを確認したい場合は、任意の部位に複数測定点を設け、各測定点におけるたるみ量の変化を比較する等して評価することができる。
測定点のマーキング方法については、顔面を測定する場合は、例えば、被験者を座位にし、顕著にたるみが発生すると考えられる目尻から垂直下方向、口角から水平外側方向の交点に、ペンなどで直接、あるいは小円形のカラーラベルなどのシールとすることができる。
The number of measurement points in the present invention can be appropriately set at 1, 2 or more, depending on the purpose. For example, in the evaluation of cosmetics, if you want to check which part of the face is particularly effective when applied to the entire face, set multiple measurement points on arbitrary parts and compare the change in the amount of sagging at each measurement point. can be evaluated equally.
Regarding the method of marking the measurement points, when measuring the face, for example, the subject is placed in a sitting position, and a pen or the like is used directly at the intersection point of the vertical downward direction from the outer corner of the eye and the horizontal outward direction from the corner of the mouth, where significant sagging is thought to occur. Alternatively, it can be a seal such as a small circular color label.

本発明における囲み部は、測定点を含む一定の領域における変化を把握する目的で設ける。そのため、一定の領域の皮膚の動きを妨げないよう囲み部は皮膚の動きに伴って変形可能であれば良い。例えば、ペン等で直接、あるいはインクなどでスタンプする方法が挙げられる。皮膚の動きに伴って変形するのであれば、伸縮可能な素材のシール等も使用できる。囲み部を変形可能に設けることにより、皮膚の伸びやゆがみ等、立体的な変化を把握することができる。 The enclosing part in the present invention is provided for the purpose of grasping the change in a certain area including the measurement point. Therefore, it is sufficient that the surrounding portion is deformable with the movement of the skin so as not to hinder the movement of the skin in a certain area. For example, a method of directly using a pen or the like or a method of stamping with ink or the like can be used. A seal or the like made of a stretchable material can also be used as long as it deforms with the movement of the skin. By providing a deformable surrounding portion, three-dimensional changes such as stretching and distortion of the skin can be grasped.

囲み部の位置は、測定点の周囲を囲むように設ければよく、円、楕円、その他の形状等であってもよいが、円、楕円であると皮膚の微妙な変化を捉えることができるのでより好ましい。この場合において、完全に閉鎖状態で囲む必要はなく、破線、点線でもよく、一部開口している状態であっても、皮膚の動きに伴って変化が把握できれば問題ない。また、囲み部の中心に測定点がある必要はないが、変化の把握の容易さから、測定点を中心として略円形にインクなどでスタンプをすることが好ましい。 The position of the enclosing part may be provided so as to enclose the circumference of the measurement point, and may be a circle, an ellipse, or other shapes, but a circle or an ellipse can capture subtle changes in the skin. Therefore, it is more preferable. In this case, it is not necessary to completely close the area. A dashed line or a dotted line may be used. Even if the area is partially open, there is no problem as long as the change can be grasped with the movement of the skin. Also, although it is not necessary to have the measurement point in the center of the enclosing part, it is preferable to stamp with ink or the like in a substantially circular shape around the measurement point in order to easily grasp the change.

撮像方法は、特に限定されない。例えば、デジタルカメラ、銀塩カメラ、インスタントカメラ等を用いることができる。アナログ画像を得た後で任意の機器に取り込みデジタル変換したものを用いても構わない。 An imaging method is not particularly limited. For example, a digital camera, a film camera, an instant camera, etc. can be used. After obtaining an analog image, it may be taken into an arbitrary device and converted into a digital image, and then used.

水平位皮膚表面画像と垂直位皮膚表面画像の入手方法は特に限定されない。例えば、被験者をベット等に仰向けにさせた状態(仰臥位)で、撮像して水平位皮膚表面画像とし、被験者を椅子等に座らせた状態(座位)、あるいは壁際等に立たせた状態(立位)で撮像して垂直位皮膚表面画像とすることができる。 The method of obtaining the horizontal skin surface image and the vertical skin surface image is not particularly limited. For example, a horizontal skin surface image is obtained by imaging the subject lying on his or her back on a bed (supine position), and the subject is placed in a chair (sitting position) or standing against a wall (standing position). position) to obtain a vertical skin surface image.

撮像順は特に限定されないが、水平位、垂直位皮膚表面画像をそれぞれ撮像し、後から基準点を重ね合わせても良いし、画像を重ね合わすことのできるアプリケーション等を用いて、水平位又は垂直位皮膚表面画像の一方を撮像した後、得られた像の基準点を合わせるようにして他方位画像を撮像しても良い。 The order of imaging is not particularly limited, but horizontal and vertical skin surface images may be captured separately and the reference point may be superimposed later, or horizontal or vertical skin surface images may be superimposed using an application that can superimpose images. After one side of the skin surface image is captured, the other side image may be captured by aligning the reference points of the obtained image.

撮像は、少なくとも1つの基準点と測定点が含まれるように行う。囲み部は必ずしも全体が撮像される必要はない。囲み部の一部が像に含まれてない場合であっても、たるみを測定、評価することは可能である。像中に含まれる囲み部の形状や面積などの変化を把握できるからである。 Imaging is performed so as to include at least one reference point and measurement point. The enclosing part does not necessarily have to be imaged in its entirety. It is possible to measure and evaluate the sag even if part of the surrounding portion is not included in the image. This is because changes in the shape, area, etc. of the enclosing portion included in the image can be grasped.

撮像における測定点と撮像レンズの位置は、特に限定されない。例えば、顔を測定する場合、後頭部が接する面に対してカメラレンズを平行に、かつ一定の距離となるように固定した場合は、この同条件下で、水平位、垂直位の撮像を行うことができる。測定前後において条件が一定であればよく、必ずしも頭が接する面に対してカメラレンズを平行にする必要はない。 The positions of the measurement point and the imaging lens in imaging are not particularly limited. For example, when measuring the face, if the camera lens is fixed parallel to the surface where the back of the head is in contact and at a constant distance, images should be taken horizontally and vertically under the same conditions. can be done. It is sufficient if the conditions are constant before and after the measurement, and it is not necessary to make the camera lens parallel to the surface with which the head is in contact.

たるみ量の計測は、水平位、垂直位の皮膚表面画像を得た後に基準点を重ね合わせ、測定点や囲み部の変化をトレーシングペーパー等に写した後で測定しても良いし、像を重ねて撮影することのできるアプリケーション等を使用して撮像した後、そのまま公知の画像解析装置等を用いて測定しても良い。 The amount of sagging can be measured by superimposing the reference points after obtaining the horizontal and vertical images of the skin surface, and then measuring the changes in the measurement points and the surrounding area on tracing paper. After taking an image using an application or the like capable of superimposing and taking an image, the measurement may be performed directly using a known image analysis device or the like.

たるみの原因は、 被験者の任意の皮膚のたるみ量を本願方法で測定し、後述する皮膚の物性状態や変化との相関関係情報を用いて判定することができる。
例えば、予め任意の複数人のたるみ量と皮膚の物性を測定し、それらの関係性をデータベースとし、被験者のたるみ量を当該データベースと照合し、当該被験者のたるみの原因を判定することが挙げられる。加えて、当該判定結果をもとに、たるみの原因に対応する皮膚外用剤又は経口投与剤の提供が可能になる。
The cause of sagging can be determined by measuring the amount of sagging of the subject's arbitrary skin by the method of the present application and using correlation information with physical properties and changes in the skin, which will be described later.
For example, the amount of sagging and the physical properties of the skin of any plurality of people are measured in advance, the relationship between them is used as a database, the amount of sagging of the subject is compared with the database, and the cause of the sagging of the subject is determined. . In addition, based on the determination result, it is possible to provide an external skin preparation or an orally administered preparation that addresses the cause of sagging.

以下、各パラメータについて説明する。
測定点の「変位距離」とは、上述の方法で得た垂直位皮膚表面画像と水平位皮膚表面画像を、基準点等を目安に重ね合わせ、水平位皮膚表面画像の測定点を始点とし、垂直位皮膚表面画像の測定点を終点とした際の両点間の距離を意味する。「変位距離」により、たるみの程度を把握することができる。
Each parameter will be described below.
The "displacement distance" of the measurement point is obtained by superimposing the vertical skin surface image and the horizontal skin surface image obtained by the above method using the reference point as a guide, and using the measurement point of the horizontal skin surface image as the starting point, It means the distance between both points when the measurement point of the vertical skin surface image is the end point. The degree of slack can be grasped by the "displacement distance".

測定点の「変位方向」とは、水平位皮膚表面画像の測定点を始点とし、垂直位皮膚表面画像の測定点を終点とする線の向きをさし、上述の方法で得た水平位皮膚表面画像と垂直位皮膚表面画像を、基準点等を目安に重ね合わせ、水平位皮膚表面画像の測定点を始点とし、垂直位皮膚表面画像の測定点を終点とした際の、始点から終点に向かう矢印が、どの方向を指しているかを意味する。
例えば、測定点を人の頬とした場合に、当該矢印が顔の中心線方向であるか(内向き)、顔の中心線方向とは逆向きであるか(外向き)であるかを意味する(図2参照)。
The "displacement direction" of the measurement point refers to the direction of a line starting from the measurement point of the horizontal skin surface image and ending at the measurement point of the vertical skin surface image. The surface image and the vertical skin surface image are superimposed using a reference point as a guide, and the horizontal skin surface image measurement point is the starting point, and the vertical skin surface image measurement point is the end point. It means which direction the arrow is pointing.
For example, if the measurement point is a person's cheek, it means whether the arrow is in the direction of the center line of the face (inward direction) or in the opposite direction to the center line direction of the face (outward direction). (see Figure 2).

「変位角」とは、水平位の皮膚表面像と垂直位の皮膚表面像の各測定点を結ぶ線と水平線のなす角度をさし、上述の方法で得た水平位皮膚表面画像と垂直位皮膚表面画像を、基準点等を目安に重ね合わせ、水平位皮膚表面画像の測定点を始点とし、垂直位皮膚表面画像の測定点を終点とした際の、始点から終点に向かう矢印を動径とし、終点を通る水平線(地球の重力の方向と垂直に交わる線)をX軸とした時にできる正の角度(=図中θ)を意味する(図3参照)。
変位角により、皮膚のたるみの方向を把握することができる。
変位角は、得られた値をそのまま評価しても良いし、向きとその程度を簡便に把握するため、得られた値から90°を差し引いた値を変位角評価値としても良い(数1)。尚、変位角とたるみの向きとの関係は、測定点の場所(頬の場合であれば、左頬か、右頬か)や、撮影画像が鏡像か正像かによって異なるので、実態に合わせて適宜調整して把握する必要がある。図3では、左頬に測定点を設け、鏡像を得て分析した場合である。
The “displacement angle” refers to the angle formed by the horizontal line and the line connecting each measurement point of the horizontal skin surface image and the vertical skin surface image. The skin surface images are superimposed using reference points, etc. as a guide, and the measurement point of the horizontal skin surface image is the starting point, and the measurement point of the vertical skin surface image is the ending point. and the positive angle (= θ 1 in the figure) formed when the horizontal line passing through the end point (the line perpendicular to the direction of gravity of the earth) is set as the X axis (see Fig. 3).
The direction of sagging of the skin can be grasped from the displacement angle.
For the displacement angle, the obtained value may be evaluated as it is, or a value obtained by subtracting 90° from the obtained value may be used as the displacement angle evaluation value (Equation 1 ). Note that the relationship between the displacement angle and the direction of sagging differs depending on the location of the measurement point (if it is a cheek, whether it is the left cheek or the right cheek) and whether the photographed image is a mirror image or a normal image. It is necessary to adjust it appropriately and grasp it. In FIG. 3, a measurement point is provided on the left cheek, and a mirror image is obtained for analysis.

Figure 0007271255000001
Figure 0007271255000001

「方位角」とは、物体の絶対最大長となる線と水平線とがなす角度を意味する。具体的には、囲み部をすべて実線で表したと想定した際の当該囲み部の最大長となる点を結んだ線と、水平線とのなす負の角度(=図中θ)を意味する(図4参照)。方位角により、皮膚のゆがみを把握することができる。 "Azimuth" means the angle between the line of absolute maximum length of the object and the horizon. Specifically, it means the negative angle (= θ 2 in the drawing) formed between the horizontal line and the line connecting the maximum length points of the enclosing portion when it is assumed that the enclosing portion is all represented by solid lines. (See Figure 4). From the azimuth angle, it is possible to grasp the distortion of the skin.

「方位角の変化量」とは、「垂直位皮膚表面画像から得た方位角」より「水平位皮膚表面画像から得た方位角」を差し引いた値を、水平位皮膚表面画像から得た方位角で割った値である。
方位角の変化量に100をかけて、変化率として把握することもできる。
“Amount of change in azimuth angle” is the value obtained by subtracting the “azimuth angle obtained from the horizontal skin surface image” from the “azimuth angle obtained from the vertical skin surface image”. It is the value divided by the angle.
The amount of change in the azimuth angle can be multiplied by 100 to obtain the rate of change.

Figure 0007271255000002
Figure 0007271255000002

Figure 0007271255000003
Figure 0007271255000003

「長短比」とは、囲み部をすべて実線で表したと想定した際の当該囲み部の長軸長さを分母とし、短軸長さを分子とした値である。
「長短比の変化量」とは、「垂直位表面画像から得た長短比」より「水平位表面画像から得た長短比」を差し引いた値を「水平位表面画像から得た長短比」で割った値である。
長短比の変化量に100をかけて、変化率として把握することもできる。
The “length ratio” is a value in which the length of the long axis of the enclosing portion is the denominator and the length of the short axis is the numerator, assuming that the enclosing portion is all represented by solid lines.
"Amount of change in length ratio" is the value obtained by subtracting "length ratio obtained from horizontal surface image" from "length ratio obtained from vertical surface image" as "length ratio obtained from horizontal surface image". is the divided value.
The amount of change in the length ratio can be multiplied by 100 to obtain the rate of change.

Figure 0007271255000004
Figure 0007271255000004

Figure 0007271255000005
Figure 0007271255000005

「面積」とは、囲み部をすべて実線で表したと想定した際の当該囲み部の面積である。
「面積変化量」とは「垂直位皮膚表面画像から得た面積値」より「水平位皮膚表面画像から得た面積値」を差し引いた値を「水平位皮膚表面画像から得た面積値」で割った値である。
面積変化量に100をかけて、変化率として把握することもできる。
囲み部は、皮膚の変化に伴って変形するように設けられるので、例えばボトルキャップ等を使用してマーキングした場合であっても、皮膚が重力により下方に引っ張られると、囲み部も下方に引っ張られ、結果として、囲み部の面積はマーキング当初の面積より異なって把握される。
The “area” is the area of the enclosing part when it is assumed that the enclosing part is all represented by solid lines.
“Amount of change in area” is the value obtained by subtracting the “area value obtained from the horizontal skin surface image” from the “area value obtained from the vertical skin surface image” as the “area value obtained from the horizontal skin surface image”. is the divided value.
The area change amount can be multiplied by 100 to obtain a rate of change.
Since the surrounding part is provided so as to deform with changes in the skin, even if the marking is done using a bottle cap or the like, when the skin is pulled downward by gravity, the surrounding part is also pulled downward. As a result, the area of the enclosing portion is perceived differently than the initial marking area.

Figure 0007271255000006
Figure 0007271255000006

Figure 0007271255000007
Figure 0007271255000007

以下、具体的な皮膚のたるみ量の測定方法、分析方法を具体的に説明するが、本発明はこれらの実施例に限定されるものではないことは言うまでもない。 Specific methods for measuring and analyzing the amount of skin sagging will be specifically described below, but it goes without saying that the present invention is not limited to these examples.

顔面皮膚のたるみ量測定の被験者として、20歳代から50歳代の健常女性40名を対象にして測定した。被験者の各年齢群の人数を表1に示した。 Forty healthy women in their twenties to fifties were used as subjects for measuring the amount of sagging of the facial skin. Table 1 shows the number of subjects in each age group.

Figure 0007271255000008
Figure 0007271255000008

<水平位皮膚表面画像と垂直位皮膚表面画像の入手>
被験者を座位かつ、前方を見つめさせた状態で、被験者の左半顔の目尻から垂直下方向、口角から水平外側方向の交点に青色の小円形シール(直径5mm)を貼り付けた。次に、外径27mm(内径25mm)のボトルキャップの円形部にアイライナーを塗布し、先に頬部に貼り付けた小円形シール(=測定点)を中心として、皮膚上にスタンプし、円形マークをつけ「囲み部」とした。さらに、小円形シールを眉間中心部、鼻の最高部、顎中心部、眉山、目尻にも貼り付け、これらを基準点とした。また、スケールとして、キャスマッチ(画像補正用カラーチャート 株式会社 ベアーメディック)を一辺がほぼ水平となるように額中央部に貼りつけた。
<Obtaining a horizontal skin surface image and a vertical skin surface image>
With the subject sitting and looking forward, a small blue circular sticker (5 mm in diameter) was attached to the left half of the subject's face at the intersection of the vertical downward direction from the outer corner of the eye and the horizontal outward direction from the corner of the mouth. Next, apply eyeliner to the circular part of the bottle cap with an outer diameter of 27 mm (inner diameter of 25 mm), and stamp it on the skin around the small circular sticker (= measurement point) that was previously attached to the cheek. A mark was added to indicate the “enclosed portion”. Furthermore, small circular stickers were attached to the center between the eyebrows, the highest part of the nose, the center of the chin, the peak of the eyebrows, and the corners of the eyes, and these were used as reference points. In addition, as a scale, Casmatch (color chart for image correction, Bearmedic Co., Ltd.) was attached to the center of the forehead so that one side was almost horizontal.

<被測定部位の撮影>
上述の方法で測定点、囲み部、基準点及びスケールを付した被験者を寝台に仰臥位にさせた状態にする。仰臥した被験者の顔正面に画像撮影用カメラを設置し、水平位の写真を撮影した(鏡像)。撮影には予めオーバーレイアプリケーション(Overlay Camera:ddquick提供)をインストールしたスマートフォンを使用した。得られた画像を水平位皮膚表面画像とした。
次に、被験者の体勢を座位に変え、被験者の顔正面に画像撮影用カメラを設置し、スマートフォン画面上に先に撮影した水平位皮膚表面画像を呼び出した状態で、基準点を重ねるように撮影した(鏡像)。これを垂直位皮膚表面画像とした。なお、この際、複数回撮影すると、解析結果の精度が向上する。
<Photography of the part to be measured>
The test subject, having the points of measurement, encircled part, reference points and scale attached by the method described above, is placed in a supine position on a bed. An imaging camera was placed in front of the face of the subject lying on his back, and a horizontal photograph was taken (mirror image). A smartphone in which an overlay application (Overlay Camera: provided by ddquick) was installed in advance was used for photographing. The obtained image was used as a horizontal skin surface image.
Next, the subject's posture is changed to a sitting position, the camera for image capture is installed in front of the subject's face, and the horizontal position skin surface image taken earlier is called up on the smartphone screen, and the reference point is superimposed. (mirror image). This was used as the vertical skin surface image. In addition, at this time, the accuracy of the analysis result is improved by photographing a plurality of times.

<たるみ量の測定>
(1)まず、垂直位皮膚表面画像と水平位皮膚表面画像が重なり合っている画像を開き、この画像上の垂直位、水平位の各測定点を結ぶ1本線と、垂直位皮膚表面画像の測定点を通る水平線を引いて、保存した。
(1-2)「測定点の変位距離」は、画像処理ソフト(WinROOF:三谷商事、以下同じ。)上で、(1)で保存した画像を呼び出し、同画面上にあるスケールのいずれかの1辺を長さ1cmとキャリブレーション設定した後、垂直位、水平位の各測定点を結ぶ1本線の長さを算出した。
(1-3)「変位角」は、画像処理ソフト上で、(1)で保存した画像を呼び出し、垂直位、水平位の各測定点を結ぶ1本線と垂直位皮膚表面画像の測定点を通る水平線をドラッグし、この2本線がつくる角度を算出した。
(2)次に、垂直位皮膚表面画像と水平位皮膚表面画像が重なり合っている画像を紙面印刷した。出力した画像上の垂直位、水平位の各囲み部と同画面上にあるスケールのいずれかの1辺をトレーシングペーパーに重なり合わないように、ペンでトレースし、画像保存した。画像処理ソフト上で、先に保存した画像を呼び出し、画面上にあるスケールの1辺を長さ1cmとキャリブレーション設定した。
(2-1)「方位角」は、適切なしきい値を設定した2値化処理を施して、囲み部を範囲指定した。次に、形状特徴の項目中の方位角を選択し、算出した。
(2-2)「長短比」は、適切なしきい値を設定した2値化処理を施して、囲み部を範囲指定した。次に、形状特徴の項目中の楕円長短比を選択し、算出した。
(2-3)「面積」は、適当なしきい値で設定した2値化処理を施して、囲み部を範囲指定した。次に、形状特徴の項目中の面積を選択し、算出した。
<Measurement of slack amount>
(1) First, open an image in which the vertical skin surface image and the horizontal skin surface image are overlapped, and measure the vertical skin surface image with one line connecting the vertical and horizontal measurement points on this image. Draw a horizontal line through the points and save.
(1-2) "Displacement distance of the measurement point" is obtained by calling the image saved in (1) on the image processing software (WinROOF: Mitani Shoji, hereinafter the same), and selecting one of the scales on the same screen. After setting one side to have a length of 1 cm for calibration, the length of one line connecting the vertical and horizontal measurement points was calculated.
(1-3) “Displacement angle” is obtained by calling the image saved in (1) on the image processing software, and connecting the measurement points of the vertical and horizontal skin surface images with a single line connecting the vertical and horizontal measurement points. I dragged the horizontal line that passes through and calculated the angle that these two lines make.
(2) Next, an image in which the vertical skin surface image and the horizontal skin surface image are overlapped was printed on paper. The vertical and horizontal enclosing portions on the output image and any one side of the scale on the same screen were traced with a pen so as not to overlap on the tracing paper, and the image was saved. On the image processing software, the previously saved image was called, and one side of the scale on the screen was set to have a length of 1 cm for calibration.
(2-1) "Azimuth" is subjected to binarization processing with an appropriate threshold value, and the enclosed portion is designated as a range. Next, the azimuth angle was selected and calculated from among the shape feature items.
(2-2) "Long-short ratio" was subjected to binarization processing with an appropriate threshold value, and the enclosing part was designated as a range. Next, the length ratio of the ellipse was selected and calculated from among the shape feature items.
(2-3) "Area" is binarized with an appropriate threshold value, and the enclosing portion is designated as a range. Next, the area in the shape feature item was selected and calculated.

<他因子とたるみ量との関係>
顔面皮膚のたるみ量測定に加え、測定点における角層水分量、皮膚弾力性、真皮中コラーゲン密度、角層細胞の面積と全身の皮下脂肪率を測定した。 尚、皮膚の物性は以下の内容に限られず、他の物性値を用いることができることは言うまでもない。
<測定条件>
(1) 馴化時間
被験者は、クレンジング剤、洗顔料を用いて洗顔した後、測定室と同じ環境下で15分間以上馴化させた後、測定に臨んだ。
(2) 測定室環境条件
測定室の環境は、温度22℃、湿度50%とした。
<測定項目>
(1)角層水分量
角層水分量は、SKICON-200EX(ヤヨイ社製)を用いて測定した。水平位での測定点の水分量を5回測定し、平均値を角層水分量とした。
(2)皮膚弾力性
皮膚弾力性はキュートメーター(courage and Khazaka社製、MPA580)を用いて測定した。測定条件は、プローブ測定開口部2mm、陰圧300mbar、陰圧時間及び陰圧開放時間は各5秒とした。結果は弾力性(=R7)(陰圧開放後0.1秒後の戻り距離を陰圧5秒後の最大伸展距離で割った値、つまり最大伸長に対する皮膚の瞬間的な戻り率)を用いた。水平位での測定点の皮膚弾力性を4回測定し、その平均値を皮膚弾力性値とした。
(3)真皮中コラーゲン密度
真皮中コラーゲン密度は、超音波真皮画像装置DermaLab(Cortex Technology社製)を用いて測定した。
Gain(感度)を7とし、水平位での測定点を5回測定し、Int.パラメーターの平均値を真皮中コラーゲン密度値とした。
(4)全身皮下脂肪率
全身皮下脂肪率は、体重体組成計Karada Scan(オムロン社製、HBF-375)を用いて測定した。
素足で測定機器にのり、1回測定を行い、その値を全身皮下脂肪率とした。
(5)角層細胞の面積
角層チェッカー(プラスチックプレートタイプ プロモツール社製)を用いて、水平位での測定点の角層細胞を採取した。テープの角層粘着部をエタノールに10分間浸漬後、10―30分間風乾し、角層染色液(ナフトールブルーブラック 0.1g、酢酸ナトリウム0.82g、酢酸 9g、蒸留水 残部)に30分間浸漬した。10分間流水にて洗浄後一晩風乾した。撮影機能付き顕微鏡(BZ-X700,KEYENCE, 20倍)にて上記処理後の角層画像を取得し、プリントアウトした画像上の細胞の輪郭をトレーシングペーパーにトレースし、スキャナー(Docucenter-V C4476,富士ゼロックス)で取り込んだ。画像解析ソフト 上で細胞の輪郭を抽出後輪郭内の面積を計測した。
<解析>
各パラメーター間の解析は、ピアソンの相関分析を行った後、有意差については、Tukey-Kramer法にて多重比較検定した。
<Relationship between other factors and sagging amount>
In addition to measuring the amount of sagging of the facial skin, the water content of the stratum corneum, skin elasticity, collagen density in the dermis, the area of stratum corneum cells, and the subcutaneous fat percentage of the whole body were measured. It goes without saying that the physical properties of the skin are not limited to those described below, and that other physical properties can be used.
<Measurement conditions>
(1) Acclimation time After washing the face with a cleansing agent and facial cleanser, the subject was allowed to acclimatize for 15 minutes or more in the same environment as the measurement room before taking measurements.
(2) Environmental conditions of the measurement room The environment of the measurement room was set at a temperature of 22°C and a humidity of 50%.
<Measurement items>
(1) Stratum corneum moisture content The stratum corneum moisture content was measured using SKICON-200EX (manufactured by Yayoi Co., Ltd.). The water content at the measurement points in the horizontal position was measured five times, and the average value was taken as the stratum corneum water content.
(2) Skin elasticity Skin elasticity was measured using a cutometer (manufactured by Courage and Khazaka, MPA580). The measurement conditions were a probe measurement opening of 2 mm, negative pressure of 300 mbar, negative pressure time and negative pressure release time of 5 seconds each. The result uses elasticity (=R7) (the value obtained by dividing the return distance after 0.1 seconds after releasing the negative pressure by the maximum stretch distance after 5 seconds of negative pressure, that is, the instantaneous return rate of the skin with respect to the maximum stretch). board. The skin elasticity was measured four times at the measurement points in the horizontal position, and the average value was taken as the skin elasticity value.
(3) Dermal Collagen Density Dermal collagen density was measured using an ultrasonic dermal imager, DermaLab (manufactured by Cortex Technology).
Gain (sensitivity) is set to 7, measurement points in the horizontal position are measured 5 times, and Int. The average value of the parameters was taken as the collagen density value in the dermis.
(4) Percentage of whole body subcutaneous fat The percentage of whole body subcutaneous fat was measured using a body composition meter Karada Scan (manufactured by Omron, HBF-375).
The person stepped on the measuring instrument with bare feet and measured once, and the value was defined as the total body subcutaneous fat percentage.
(5) Area of stratum corneum Using a stratum corneum checker (plastic plate type, manufactured by Promotool), stratum corneum cells at the measurement points in the horizontal position were collected. The stratum corneum adhesive part of the tape was immersed in ethanol for 10 minutes, air-dried for 10 to 30 minutes, and immersed in stratum corneum staining solution (naphthol blue black 0.1 g, sodium acetate 0.82 g, acetic acid 9 g, distilled water remaining) for 30 minutes. bottom. After washing with running water for 10 minutes, it was air-dried overnight. A stratum corneum image after the above processing was acquired with a microscope with a photographing function (BZ-X700, KEYENCE, 20x), the outline of the cells on the printed out image was traced on tracing paper, and a scanner (Docucenter-VC4476 , Fuji Xerox). After extracting the contour of the cell on the image analysis software, the area within the contour was measured.
<Analysis>
After Pearson's correlation analysis was performed for each parameter analysis, a multiple comparison test was performed using the Tukey-Kramer method for significant differences.

図5は、変位距離と年齢との散布図である。
二姿勢による測定点の変位距離は、年齢との間に強い相関性(R=0.65 p<0.01)が確認された。これより、年齢が高くなるにつれ、測定点の変位距離が長くなり、測定点のたるみ量は大きくなることが明確となった。
FIG. 5 is a scatter diagram of displacement distance and age.
A strong correlation (R = 0.65 p < 0.01) was confirmed between the displacement distance of the measurement point by two postures and age. From this, it was clarified that the displacement distance at the measurement point increased and the amount of slack at the measurement point increased with age.

図6は、測定点の変位距離と全身皮下脂肪率との散布図である。変位距離と全身皮下脂肪率との間に弱い相関性(R=0.24 p<0.01)が確認された。全身皮下脂肪率が高いほど、測定点のたるみ量は大きくなることが明確となった。 FIG. 6 is a scatter diagram of the displacement distance of measurement points and the whole body subcutaneous fat percentage. A weak correlation (R=0.24 p<0.01) was identified between displacement distance and total body subcutaneous fat percentage. It became clear that the higher the whole body subcutaneous fat percentage, the greater the amount of sagging at the measurement point.

変位角とその他パラメーターとの関係
測定点の変位前後位置を結ぶ線と変位後の点を通る水平線とがなす変位角が90°より増加する現象は、この回の実験では、仰臥位から座位に体勢を変化させる際に、測定点が顔の中心線に向かって移動していることを示す。逆に90°より減少する現象は、仰臥位から座位に体勢を変化させる際に、測定点が顔の中心線から外側方向へ移動することを示す。さらに、この変位角は、測定点の角層水分量と負の相関性(R=-0.26 p<0.01)、測定点の肌の弾力性を示すパラメーターR7と負の相関性(R=-0.46p<0.01)が確認された(図7、8)。さらには、年齢とは正の相関性が確認された。(R=0.25 p<0.01)。これより、測定点の変位前後位置を結ぶ線と変位後の点を通る水平線とがなす変位角の増加と共に、測定点の肌の水分量や弾力性が減少し、年齢が増加することが明確となった。
Relationship between displacement angle and other parameters In this experiment, the phenomenon that the displacement angle formed by the line connecting the positions of the measurement points before and after displacement and the horizontal line passing through the points after displacement increased beyond 90° Indicates that the measurement point moves toward the center line of the face when changing posture. Conversely, the phenomenon of less than 90° indicates that the measurement point moves outward from the center line of the face when the posture is changed from the supine position to the sitting position. Furthermore, this displacement angle has a negative correlation with the stratum corneum water content at the measurement point (R = -0.26 p < 0.01), and a negative correlation with the parameter R7 indicating skin elasticity at the measurement point ( R=−0.46p<0.01) was confirmed (FIGS. 7 and 8). Furthermore, a positive correlation was confirmed with age. (R=0.25 p<0.01). From this, it is clear that as the displacement angle formed by the line connecting the positions before and after the displacement of the measurement point and the horizontal line passing through the point after displacement increases, the moisture content and elasticity of the skin at the measurement point decrease, and the age increases. became.

方位角とその他パラメーターとの関係
方位角(囲み部の絶対最大長ラインと水平ラインとがなす角度)の2姿勢における変化率は、年齢と正の相関性を示した(R=0.43 p<0.01)(図9)。方位角の増加は、仰臥位から座位に姿勢を変えると、囲み部の最大長ラインの角度が斜めから垂直よりに変化していることを表しており、囲み部を施した範囲内でも、より顎先に近い位置が遠い位置よりもより姿勢変化による位置変化が大きいことに起因している。さらに、その動向が年齢増加と共に顕著になることが明確となった。一方、方位角の2姿勢における変化率は、測定点の角層水分量および、コラーゲン密度とも負の相関性(R=-0.27 p<0.01、R=-0.25 p<0.01)を示していることが明らかとなった。(図10、11)よって、姿勢を変化させることにより生ずる方位角の変化率は、年齢および、真皮や角層の性状に影響を受けていることが推測できる。
Relationship between azimuth angle and other parameters The rate of change of azimuth angle (the angle formed by the absolute maximum length line and the horizontal line of the enclosed part) in two postures showed a positive correlation with age (R = 0.43 p <0.01) (Fig. 9). The increase in the azimuth angle indicates that the angle of the maximum length line of the enclosing part changes from oblique to vertical when the posture is changed from the supine position to the sitting position. This is due to the fact that the position closer to the tip of the chin undergoes a greater positional change due to the change in posture than the position farther away. Furthermore, it became clear that the tendency becomes remarkable with the age increase. On the other hand, the rate of change of the azimuth angle in the two postures has a negative correlation with the stratum corneum water content at the measurement point and the collagen density (R = -0.27 p < 0.01, R = -0.25 p < 0 .01). (FIGS. 10 and 11) Therefore, it can be inferred that the rate of change in the azimuth angle caused by changing the posture is influenced by the age and the properties of the dermis and stratum corneum.

囲み部の形状変化(長短比、面積)とその他パラメーターとの関係
長短比変化率は全身皮下脂肪率との間に負の相関性(R=-0.31 、p<0.01)、コラーゲン密度、角層細胞面積とは正の相関性(R=0.36 、p<0.01、R=0.36 、p<0.01)が認められた。
長短比変化率の減少は、囲み部が正円形状から楕円形状方向に変化することを表しており、姿勢を変えることに伴い、囲み部の垂直方向だけでなく、後頭部方向への変位が大きいことが起因して生じるゆがみの増加を表している。
全身皮下脂肪率が増加し、測定点のコラーゲン密度、角層細胞面積が減少すると共に、姿勢を変えることにより生じる囲み部の長短比変化率が減少することが明らかとなり、つまり、たるみからくるゆがみが増加していると推測できる。一方で、この長短比変化率は、年齢との関係性は確認できなかった(図12~15)。
一方、面積変化率は、全身皮下脂肪率との間に負の相関性(R=-0.21 、p<0.01)があり、他のパラメーターとの関係性も長短比変化率と類似していることが明らかとなった。(図16)これより、姿勢を変化させることにより生ずる長短比変化率及び、面積変化率は、年齢とは関係なく、身体や皮膚の性状に影響を受けていることが推測できる。
Relationship between shape change (length ratio, area) of the surrounding part and other parameters There is a negative correlation between the length ratio change rate and the whole body subcutaneous fat percentage (R = -0.31, p < 0.01), collagen A positive correlation (R = 0.36, p < 0.01, R = 0.36, p < 0.01) was observed with density and stratum corneum cell area.
A decrease in the rate of change in length ratio indicates that the enclosing part changes from a perfect circular shape to an elliptical shape. It represents an increase in distortion caused by
It was found that the ratio of subcutaneous fat of the whole body increased, the collagen density at the measurement point and the area of stratum corneum cells decreased, and the rate of change in length ratio of the surrounding part caused by changing posture decreased. can be assumed to increase. On the other hand, the relationship between age and age could not be confirmed for this long-short ratio change rate (FIGS. 12 to 15).
On the other hand, the area change rate has a negative correlation with the whole body subcutaneous fat percentage (R = -0.21, p < 0.01), and the relationship with other parameters is also similar to the length ratio change rate. It became clear that (FIG. 16) From this, it can be inferred that the length ratio change rate and the area change rate caused by changing the posture are affected by the properties of the body and skin, regardless of age.

これらの結果から、予め本願の方法を用いて得たたるみ量と、各種皮膚物性との関係を把握すれば、被験者のたるみ量から、当該被験者のたるみの原因を判定することが可能になると言える。 From these results, it can be said that if the relationship between the amount of sagging obtained by using the method of the present application and various skin properties is grasped in advance, it will be possible to determine the cause of sagging of the subject from the amount of sagging of the subject. .

以上より、本願発明の方法を用いれば、簡便な方法でたるみ量を測定することができ、そのたるみの原因も推測、判定することができるので、たるみの改善にむけたより良い提案が可能となる。
As described above, if the method of the present invention is used, the amount of sagging can be measured in a simple manner, and the cause of the sagging can also be estimated and determined, making it possible to make better proposals for improving the sagging. .

Claims (4)

皮膚のたるみ量を測定する方法において
(1) 被験者の皮膚に基準点を設けるステップ
(2) 基準点とは異なる点を測定点とするステップ
(3) 測定点から任意の距離を隔てた外周に、皮膚の形状変化に伴って変形可能な囲み部を設けるステップ
(4) 被験者を仰臥位にした姿勢で少なくとも基準点、測定点を含む状態で、水平位の皮膚表面を撮像するステップ
(5) 被験者を座位又は立位にした姿勢で、少なくとも基準点、測定点を含む状態で、垂直位の皮膚表面を撮像するステップ
(6) ステップ(4)、(5)で得られた画像から次の少なくとも1つを測定するステップ
(a-3)変位角
(a-4)方位角
(a-5)長短
含む皮膚たるみ量の測定方法。
In the method for measuring the amount of skin sagging, (1) the step of setting a reference point on the subject's skin, (2) the step of setting a point different from the reference point as the measurement point, and step (4) of providing an enclosing portion that can be deformed according to changes in the shape of the skin; step (5) of imaging the skin surface in a horizontal position in a state in which the subject is placed in a supine position and includes at least reference points and measurement points; Step (6) Imaging the skin surface in the vertical position with the subject in a sitting or standing position, including at least the reference point and the measurement point. From the images obtained in steps (4) and (5), the following measuring at least one
(a -3) Displacement angle (a-4) Azimuth angle (a-5) Length ratio
A method for measuring the amount of skin sagging, including
皮膚のたるみ量を測定する方法において
(1) 被験者の皮膚に基準点を設けるステップ
(2) 基準点とは異なる点を測定点とするステップ
(3) 測定点から任意の距離を隔てた外周に、皮膚の形状変化に伴って変形可能な囲み部を設けるステップ
(4) 被験者を仰臥位にした姿勢で少なくとも基準点、測定点を含む状態で、水平位の皮膚表面を撮像するステップ
(5) 被験者を座位又は立位にした姿勢で、少なくとも基準点、測定点を含む状態で、垂直位の皮膚表面を撮像するステップ
(6) ステップ(4)、(5)で得られた画像から次の少なくとも1つを測定するステップ
(a-1)変位距離
(a-3)変位角
(a-4)方位角
(a-5)長短比
(a-6)面積
を含む皮膚たるみ量の測定方法でたるみ量を測定し、
(7)(6)で選択した項目及び/又はその変化率と対応する、予め得た次の少なくとも1つの項目からたるみの原因を判定する方法。
(b-1)変位距離と全身皮下脂肪率との相関関係
(b-2)変位角と角層水分量との相関関係
(b-3)変位角とR7(弾力性) との相関関係
(b-4)方位角変化率と年齢との相関関係
(b-5)方位角変化率と角層水分量との相関関係
(b-6)方位角変化率とコラーゲン密度との相関関係
(b-7)長短比変化率と全身皮下脂肪率との相関関係
(b-8)長短比変化率とコラーゲン密度との相関関係
(b-9)長短比変化率と角層面積との相関関係
(b-10)長短比変化率と年齢との相関関係
(b―11)面積変化率と全身皮下脂肪率との相関関係
In the method for measuring the amount of skin sagging, (1) the step of setting a reference point on the subject's skin, (2) the step of setting a point different from the reference point as the measurement point, and step (4) of providing an enclosing portion that can be deformed according to changes in the shape of the skin; step (5) of imaging the skin surface in a horizontal position in a state in which the subject is placed in a supine position and includes at least reference points and measurement points; Step (6) Imaging the skin surface in the vertical position with the subject in a sitting or standing position, including at least the reference point and the measurement point. From the images obtained in steps (4) and (5), the following The step of measuring at least one (a-1) displacement distance (a-3) displacement angle (a-4) azimuth angle (a-5) long-short ratio (a-6) skin sagging amount measurement method including area Measure the amount of slack,
(7) A method of determining the cause of the slack from at least one of the following items obtained in advance corresponding to the item selected in (6) and/or its rate of change.
(b-1) Correlation between displacement distance and whole body subcutaneous fat percentage
(b-2) Correlation between displacement angle and stratum corneum moisture content
(b-3) Correlation between displacement angle and R7 (elasticity)
(b-4) Correlation between azimuth angle change rate and age
(b-5) Correlation between azimuth angle change rate and stratum corneum moisture content
(b-6) Correlation between azimuth angle change rate and collagen density
(b-7) Correlation between length ratio change rate and whole body subcutaneous fat percentage
(b-8) Correlation between length ratio change rate and collagen density
(b-9) Correlation between length ratio change rate and stratum corneum area
(b-10) Correlation between long-short ratio change rate and age
(b-11) Correlation between area change rate and whole body subcutaneous fat percentage
請求項1又は2に記載の方法で得られた結果からたるみの原因を判定し、原因に対応する商品及び/又はサービスを提供する方法。 A method for determining the cause of slackness from the results obtained by the method according to claim 1 or 2 and providing goods and/or services corresponding to the cause. 請求項1又は2に記載の方法用い装置 Apparatus using the method according to claim 1 or 2 .
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JP2019022483A (en) 2017-07-21 2019-02-14 ポーラ化成工業株式会社 Method for detecting risk of skin troubles, detection reagent and reagent for discriminating skin condition to be used for method, and method for selecting cosmetic or quasi drug
US20190059806A1 (en) 2017-08-31 2019-02-28 Cal-Comp Big Data, Inc. Skin aging state assessment method and electronic device
JP6473959B1 (en) 2018-05-14 2019-02-27 株式会社三砂堂漢方 Skin sagging amount measuring method and skin sagging amount measuring apparatus

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