JP7231044B2 - Management device, management method and management program for managing liquid chromatograph - Google Patents

Description

The present invention relates to a management device, management method, and management program for managing a liquid chromatograph.

In a liquid chromatograph, many parameters such as sample injection volume, mobile phase type, separation column type and column oven temperature are set as analysis conditions. Analytical conditions set in a liquid chromatograph are called an analytical method. In a liquid chromatograph, the suitable analytical method differs depending on the object to be analyzed. For example, when an analytical process to which one analysis method is applied for a certain analyte detects good peaks, but an analytical process to which a different analysis method is applied has poor peak separation. There is

Method scouting is a method of finding an analytical method that provides good analytical results while changing analytical conditions. Japanese Unexamined Patent Application Publication No. 2002-200301 discloses a system that reduces the burden of setting operations on the operator when method scouting is performed.
International Publication No. 2018-042529

In method scouting, many analytical methods are created by varying parameters as described above. A large number of created analysis methods are registered in the schedule table. The number of analysis methods registered in the schedule table increases according to the combination of setting values of each parameter.

When the analysis process is executed based on the schedule table, the number of analyzes for each separation column increases. If the number of times the separation column is used exceeds the upper limit during method scouting, the separation performance of the chromatogram is degraded. In this case, the reliability of analytical processing in method scouting is lowered, resulting in wasted time and cost.

An object of the present invention is to manage the number of analyzes of a separation column provided in a liquid chromatograph.

A first aspect of the present invention comprises an analysis number acquiring unit that acquires the number of times of analysis of a separation column, a scheduled number of times acquisition unit that acquires the scheduled number of times of analysis of the separation column based on the scheduled analysis method, and the number of times of analysis and the schedule. A liquid comprising an addition unit that adds the number of analyzes, and a comparison display unit that compares the total number of column analyzes calculated by the addition unit and the upper limit number of times, and displays a warning about the separation column when the total number of column analyzes exceeds the upper limit number of times. The present invention relates to a management device that manages chromatographs.

ADVANTAGE OF THE INVENTION According to this invention, the analysis frequency|count of the separation column with which a liquid chromatograph is provided can be managed.

FIG. 1 is an overall view of an analysis system according to an embodiment. FIG. 2 is a block diagram of a management PC that manages the liquid chromatograph according to the embodiment. FIG. 3 is a functional block diagram of a management PC that manages the liquid chromatograph according to the embodiment. FIG. 4 is a diagram showing a schedule confirmation screen. FIG. 5 is a flowchart showing a liquid chromatograph management method according to the embodiment.

Next, configurations of a liquid chromatograph management apparatus, a management method, and a management program according to an embodiment of the present invention will be described with reference to the accompanying drawings.

(1) Overall Configuration of Analysis System FIG. 1 is an overall view showing an analysis system according to an embodiment. The analysis system includes a liquid chromatograph 1 and a management PC (Personal Computer) 6 . Liquid chromatograph 1 and management PC 6 are connected to LAN (Local Area Network) 5 .

A liquid chromatograph 1 includes a system controller 2 and a column unit 3, as shown in FIG. The liquid chromatograph 1 also includes processing units such as a pump unit, an autosampler unit and a detector unit. In the liquid chromatograph 1, analysis processing is executed by operating each processing unit under the control of the system controller 2. FIG. System controller 2 is connected to management PC 6 via LAN 5 . The system controller 2 controls the liquid chromatograph 1 according to control of management PC6.

The column unit 3 comprises a first separation column 31A and a second separation column 31B. The first separation column 31A and the second separation column 31B are housed in a column oven. A mobile phase in which a sample is dissolved is supplied to the first separation column 31A or the second separation column 31B. Separation of the sample is performed while the supplied mobile phase passes through the stationary phase in the first separation column 31A or the second separation column 31B. The mobile phase flowing out from the first separation column 31A or the second separation column 31B is supplied to the subsequent detector unit.

A first column manager 32A is attached to the first separation column 31A. The first column management unit 32A stores the number of analyzes performed in the first separation column 31A. A second column manager 32B is attached to the second separation column 31B. The second column management unit 32B stores the number of analyzes performed in the second separation column 31B. The system controller 2 controls the analysis processing of the liquid chromatograph 1 and counts the number of analyzes performed in each of the first separation column 31A and the second separation column 31B. The first column management unit 32A and the second column management unit 32B receive the number of analyses, respectively, of the first separation column 31A and the second separation column 31B from the system controller 2, and add the received number of analyses to the stored number of analyses. After adding, the number of times of analysis after the addition is stored. Thereby, the first column management unit 32A and the second column management unit 32B store the cumulative number of analyzes of the first separation column 31A and the second separation column 31B, respectively.

The first column management unit 32A and the second column management unit 32B are composed of, for example, semiconductor substrates on which memories are mounted. A semiconductor substrate is housed in a case and attached to the first separation column 31A and the second separation column 31B.

(2) Configuration of Management PC FIG. 2 is a diagram showing the configuration of the management PC 6. As shown in FIG. The management PC 6 includes a CPU (Central Processing Unit) 61 , a RAM (Random Access Memory) 62 , a ROM 63 , a storage device 64 , a display 65 , an operation section 66 and a communication interface 67 . The CPU 61, RAM 62, ROM 63, storage device 64, display 65, operation section 66 and communication interface 67 are connected via a bus. A hard disk, for example, is used as the storage device 64 . The storage device 64 stores an analysis management program P1, an analysis condition setting program P2, a schedule table ST, and an upper limit number of times LT. A communication interface 67 communicates with the system controller 2 of the liquid chromatograph 1 via the LAN 5 .

The analysis management program P1 executes a process of controlling the analysis process executed in the liquid chromatograph 1, a process of analyzing the result of the analysis process executed in the liquid chromatograph 1, and the like. The analysis condition setting program P2 executes processing for setting an analysis method for analysis processing executed in the liquid chromatograph 1 . The analysis condition setting program P2 also executes processing for setting a schedule table ST for executing analysis processing as batch processing based on a plurality of analysis methods.

The schedule table ST is a table in which a plurality of analysis methods are recorded as records. The analysis management program P1 sequentially executes analysis processes based on a plurality of analysis methods recorded in the schedule table ST. Thus, in the liquid chromatograph 1, analysis processing is executed as batch processing based on the schedule table ST.

The upper limit number of times LT is the upper limit number of times of analysis processing of the first separation column 31A and the second separation column 31B. The upper limit number of times LT is set individually for each of the first separation column 31A and the second separation column 31B. The upper limit number of times LT is set by the operator. The analysis management program P1 displays on the display 65 an interface for setting the upper limit number of times LT. The operator operates the operation unit 66 to set the upper limit number of times LT for the first separation column 31A and the second separation column 31B in the setting interface.

(3) Functional Configuration of Management PC FIG. 3 is a functional block diagram of the management PC 6. As shown in FIG. The management PC 6 has a control section 7 . The control unit 7 includes an analysis number acquisition unit 71 , a scheduled number acquisition unit 72 , an addition unit 73 , a comparison display unit 74 , a method generation unit 76 and a schedule generation unit 77 . The control unit 7 is a functional unit realized by executing the analysis condition setting program P2 shown in FIG. 2 on the CPU 61 while using the RAM 62 as a work area.

The number-of-analyses acquisition unit 71 acquires the number of analyzes of the first separation column 31A from the first column management unit 32A. In addition, the number-of-analyses acquisition unit 71 acquires the number of analyzes of the second separation column 31B from the second column management unit 32B. The analysis frequency acquisition unit 71 sends an instruction to acquire the analysis frequency of the first separation column 31A and the second separation column 31B to the system controller 2 via the LAN 5 . The system controller 2 acquires the number of times of analysis of the first separation column 31A and the second separation column 31B from the first column management section 32A and the second column management section 32B, and gives it to the analysis number acquisition section 71 .

The method generation unit 76 generates analysis methods. The analytical method is defined by the set values of multiple parameters such as sample injection volume, mobile phase type, separation column type and column oven temperature. The method generation unit 76 causes the display 65 to display a parameter setting interface. The operator operates the operation unit 66 to set parameters via the setting interface.

The schedule generator 77 generates a schedule table ST based on the analysis method generated by the method generator 76 . A plurality of analysis methods are recorded as records in the schedule table ST. The analysis management program P1 executes a plurality of methods recorded in the schedule table ST as batch processing.

The scheduled number of times acquisition unit 72 refers to the schedule table ST and acquires the number of times of analysis scheduled for the first separation column 31A. The scheduled number of times acquisition unit 72 refers to the schedule table ST and acquires the number of times of analysis scheduled for the second separation column 31B. As described above, the type of separation column is set as a parameter in the analysis method recorded in the schedule table ST. The scheduled number acquisition unit 72 refers to all analysis methods recorded in the schedule table ST, and counts the number of analysis methods in which the first separation column 31A and the second separation column 31B are set. The counted number of times of analysis of the first separation column 31A is provided to the adding section 73 as the planned number of times of analysis of the first separation column 31A. The counted number of analyzes of the second separation column 31B is provided to the adding section 73 as the scheduled number of analyzes of the second separation column 31B.

The adder 73 acquires the number of analyses of the first separation column 31A and the number of analyses of the second separation column 31B from the number of analyses acquisition unit 71 . The adding unit 73 also acquires the scheduled number of analyzes for the first separation column 31A and the scheduled number of analyses for the second separation column 31B from the scheduled number of times acquisition unit 72 . The adder 73 adds the number of analyzes of the first separation column 31A and the planned number of analyses. The adder 73 adds the number of analyzes of the second separation column 31B and the planned number of analyses. The adder 73 gives the sum of the number of analyses of the first separation column 31A and the scheduled number of analyses, as the total number of analyses, of the first separation column 31A to the comparison display section 74 . The adder 73 gives the added value of the number of analyses of the second separation column 31B and the scheduled number of analyses, as the total number of analyses, of the second separation column 31B to the comparison and display section 74 .

The comparison display unit 74 compares the total number of analysis times with the upper limit number of times LT. When the total number of analyzes exceeds the upper limit number of times LT, the comparison display section 74 displays a warning on the display 65 . When the total number of times of analysis of the first separation column 31A exceeds the upper limit number of times LT of the first separation column 31A, the comparison display section 74 displays a warning about the first separation column 31A. When the total number of times of analysis of the second separation column 31B exceeds the upper limit number of times LT of the second separation column 31B, the comparison display section 74 displays a warning about the second separation column 31B.

FIG. 4 shows a schedule confirmation screen 80 displayed on the display 65 by the comparison display section 74. As shown in FIG. The schedule confirmation screen 80 includes an analysis count display portion 81 and a schedule display portion 82 . As described above, when the operator performs an analysis method setting operation, the method generation unit 76 generates the analysis method, and the schedule generation unit 77 generates the schedule table ST. After the schedule generation unit 77 generates the schedule table ST, the addition unit 73 calculates the total number of analyzes, and the comparison display unit 74 displays the schedule confirmation screen 80 on the display 65 .

The number-of-analyses display section 81 displays the total number of times of analysis and the upper limit number of times of the first separation column 31A and the second separation column 31B. In the illustrated example, 503 times are displayed as the total number of analyzes for the first separation column 31A, and 500 times are displayed as the upper limit number of times for the first separation column 31A. Further, 412 times are displayed as the total number of analyzes of the second separation column 31B, and 550 times are displayed as the upper limit number of times of analysis of the second separation column 31B. The total number of times of analysis is the number of times calculated by the adding section 73 . The upper limit number of times is the number of times obtained from the upper limit number of times LT stored in the storage device 64 . In the example shown in the figure, since the total number of analyzes of the first separation column 31A exceeds the upper limit number of times, a warning is displayed in the column of the total number of analyzes of the first separation column 31A. For example, the background color of the column of the total number of times of analysis is displayed in a conspicuous color (red, etc.) different from the background color of the surrounding area, so that the warning is displayed.

In the schedule display area 82, a plurality of analysis methods recorded in the schedule table ST are displayed in row units. By operating the scroll bar displayed in the schedule display section 82, the operator can scroll the schedule table ST vertically and refer to all analysis methods recorded in the schedule table ST. Parameters such as separation column, mobile phase, column temperature and sample injection volume are indicated for each analytical method. By operating the scroll bar displayed in the schedule display section 82, the operator can scroll the schedule table ST in the horizontal direction and refer to all the parameters set for each analysis method.

A check box 821 is provided at the left end of each analysis method displayed in the schedule display section 82 . A check box 821 is checked for an analysis method in which a separation column that exceeds the upper limit number of times is set. In the example of FIG. 4, the number of analyzes display section 81 indicates that the total number of analyzes of the first separation column 31A exceeds the upper limit number of times. Therefore, among the plurality of analysis methods displayed in the schedule display section 82, the check boxes 821 are checked for the analysis methods for which the first separation column 31A is set as the separation column. In FIG. 4, the checked checkbox 821 is shaded. In this way, the comparison display unit 74 pre-checks the check box 821 of each analysis method based on the comparison result of the total number of analysis times and the upper limit number of times for each separation column, and displays them on the display 65 . By referring to the check box 821, the operator can identify an analysis method for which the total number of analysis times of the separation column exceeds the upper limit number of times among the plurality of analysis methods registered in the schedule table ST.

The operator can correct the schedule table ST after referring to the number-of-analyses display section 81 and the schedule display section 82 . The operator can delete the analysis method from the schedule table ST by deleting the check of the checked analysis method in the schedule display section 82 . For example, the operator operates the operation unit 66 to select the check box 821 of the analysis method to be deleted in the schedule display unit 82 . As a result, the analysis method is deleted from the schedule table ST. Before deleting the unchecked analysis method from the schedule display section 82, the comparison display section 74 may display a message asking the operator to confirm the deletion. The comparison display section 74 deletes the unchecked analysis method from the schedule display section 82 after receiving the operator's confirmation operation.

As another embodiment, the schedule display unit 82 may be provided with an interface for batch deletion of analysis methods. In the example shown in FIG. 4, since the total number of analyzes of the first separation column 31A exceeds the upper limit number of times, the check box 821 is checked in the schedule display section 82 for the analysis method for which the first separation column 31A is set. It is Here, the schedule display unit 82 displays an interface for collectively deleting analysis methods related to the first separation column 31A. As an interface for collective deletion, for example, a selection list of separation columns is displayed. After selecting the first separation column 31A from the selection list, the operator performs a collective deletion operation. As a result, the analysis methods for which the first separation column 31A is set are collectively deleted from the schedule table ST. For example, it is possible to collectively delete analysis methods using a specific separation column, including pre-analysis cleaning processing, which improves operator convenience.

As described above, in the management PC 6 that manages the liquid chromatograph 1 of the present embodiment, the addition unit 73 adds the number of analyzes and the scheduled number of analyses, and the comparison display unit 74 indicates that the total number of analyzes for the column exceeds the upper limit number of analyses. In this case, a warning is displayed for the first separation column 31A and the second separation column 31B. Thereby, the management PC 6 can manage the number of analyzes of the first separation column 31A and the second separation column 31B included in the liquid chromatograph 1 . The operator can predict whether or not the analytical process can be executed normally by looking at the warning displays of the first separation column 31A and the second separation column 31B. For example, when method scouting with a large number of analyses, the number of analyses of the first separation column 31A and the second separation column 31B can be known in advance.

In addition, in the management PC 6 that manages the liquid chromatograph 1 of the present embodiment, the comparison display unit 74 corrects the schedule when the total number of column analyzes exceeds the upper limit number of times for the first separation column 31A and the second separation column 31B. Present an interface for operations. The operator can modify the schedule by operating the check box 821 of each analysis method displayed on the schedule display section 82 . As a result, it is possible to adjust the number of analysis processes and prevent unnecessary analysis processes exceeding the upper limit number of times of the separation column from being executed.

(4) Management Method FIG. 5 is a flow chart showing a management method of the liquid chromatograph 1 according to the present embodiment. The management method shown in FIG. 5 is executed by executing the analysis condition setting program P2 stored in the storage device 64 by the CPU 61 of FIG. When the operator performs the analysis method generation and schedule table ST generation operations, the method generation unit 76 generates the analysis method, and the schedule generation unit 77 generates the schedule table ST. The schedule table ST is stored in the storage device 64 . When the schedule table ST is generated, the number-of-analyses acquisition unit 71 acquires the number of analyzes of the first separation column 31A from the first column management unit 32A. In addition, the number-of-analyses acquisition unit 71 acquires the number of analyzes of the second separation column 31B from the second column management unit 32B (step S1).

Next, the scheduled number of times acquisition unit 72 refers to the schedule table ST and acquires the scheduled number of times of column analysis of the first separation column 31A. Further, the scheduled number of times acquisition unit 72 refers to the schedule table ST and acquires the scheduled number of times of column analysis of the second separation column 31B (step S2). The scheduled number acquisition unit 72 counts the number of scheduled analysis processes for each of the first separation column 31A and the second separation column 31B by referring to all the analysis methods registered in the schedule table ST.

Next, the addition unit 73 adds the number of times of analysis of the first separation column 31A and the number of times of analysis planned to calculate the total number of times of analysis of the first separation column 31A. Further, the adding unit 73 adds the number of times of analysis of the second separation column 31B and the number of times of analysis planned to calculate the total number of times of analysis of the second separation column 31B (step S3).

Next, the comparison display unit 74 compares the total number of times of analysis of the first separation column 31A and the upper limit number of times LT of the first separation column 31A. The comparison display unit 74 also compares the total number of analyzes of the second separation column 31B and the upper limit number of times LT of the second separation column 31B (step S4). Then, when the total number of analyzes of the first separation column 31A exceeds the upper limit number of times LT of the first separation column 31A, the comparison display section 74 causes the analysis number display section 81 to display a warning about the first separation column 31A. I do. Further, when the total number of analyzes of the second separation column 31B exceeds the upper limit number of times LT of the second separation column 31B, the comparison display section 74 causes the analysis number display section 81 to display a warning about the second separation column 31B. (step S5).

(5) Correspondence between each constituent element of the claims and each element of the embodiment An example of correspondence between each constituent element of the claim and each element of the embodiment will be described below. is not limited to In the above embodiment, the first separation column 31A and the second separation column 31B are examples of separation columns, and the first column manager 32A and the second column manager 32B are examples of column managers. In the above embodiment, the management PC 6 is an example of a management device. In the above embodiment, the check box 821 of the schedule display section 82 is an example of an interface for correcting the schedule.

Various elements having the configuration or function described in the claims can also be used as each component of the claims.

(6) Other Embodiments In the above embodiment, the numbers of analyzes of the first separation column 31A and the second separation column 31B are held in the first column manager 32A and the second column manager 32B, respectively. rice field. In other words, the means for storing the number of analyzes of the separation columns was individually attached to each separation column. In this aspect, the means for storing the number of analyzes of the separation column can be physically managed as a set with the separation column. As another aspect, the number of analyzes for both the first separation column 31A and the second separation column 31B may be stored in the storage device 64 of the management PC 6. FIG. In this case, the number-of-analyses acquiring unit 71 can acquire the numbers of analyzes of the first separation column 31A and the second separation column 31B from the storage device 64 . With this aspect, the management PC 6 can centrally manage the number of analyzes of a plurality of separation columns.

In the comparison display section 74 of the above embodiment, the analysis number display section 81 displays a warning by changing the background color of the separation column whose total analysis number exceeds the upper limit number. As a mode of warning display, for example, the characters or the background of the separation column whose total number of analyzes exceeds the upper limit may be displayed blinking. Alternatively, the font type and font size may be changed, such as bolding the characters of the separation columns in which the total number of analyzes exceeds the upper limit.

In the above embodiment, the case where the liquid chromatograph 1 has two separation columns (the first separation column 31A and the second separation column 31B) has been described as an example. The number of separation columns provided in the liquid chromatograph 1 is not limited to two, and may be three or more. Even in this case, a separation column manager is attached to each of the three or more separation columns, and the number of analyzes of each separation column is saved. Alternatively, in the storage device 64 of the management PC 6, the analysis counts of three or more separation columns are centrally managed. In the comparison display section 74, the total number of times of analysis is compared with the upper limit number of times for each of the three or more separation columns.

In the above embodiment, the case where the analysis management program P1 and the analysis condition setting program P2 are stored in the storage device 64 has been described. As another example, the analysis management program P1 and the analysis condition setting program P2 may be provided by being stored in a recording medium such as a CD-ROM, DVD-ROM, or semiconductor memory. The CPU 61 can execute the analysis management program P1 and the analysis condition setting program P2 stored in the recording medium via the device interface of the PC6.

The specific configuration of the present invention is not limited to the above-described embodiment, and various changes and modifications are possible without departing from the gist of the invention.

(7) Aspects It will be appreciated by those skilled in the art that the exemplary embodiments described above are specific examples of the following aspects.

(Section 1) A management device that manages a liquid chromatograph according to one aspect,
an analysis count acquisition unit that acquires the analysis count of the separation column;
a scheduled number acquisition unit that acquires the number of scheduled analyzes of the separation column based on the scheduled analysis method;
an adding unit that adds the number of times of analysis and the number of times of scheduled analysis;
a comparison display unit that compares the total number of column analyzes calculated by the addition unit and the upper limit number of times, and displays a warning about the separation column when the total number of column analyzes exceeds the upper limit number of times;
Prepare.

It is possible to manage the number of analyzes of the separation column provided in the liquid chromatograph. The operator can predict whether or not the analytical process can be executed normally by looking at the warning display of the separation column. For example, when performing method scouting with a large number of analyses, the number of analyzes of the separation column can be known in advance.

(Section 2) In the management device for managing the liquid chromatograph according to Section 1,
The analysis frequency acquisition unit may acquire the analysis frequency from a column management unit attached to the separation column.

Since the column management section is attached to the separation column, it is possible to manage the number of analyses, as a physical set with the separation column.

(Section 3) In the management device for managing the liquid chromatograph according to Section 1,
The analysis frequency acquisition unit may acquire the analysis frequency from a storage unit of the management device.

Since the number of times of analysis of the separation column is stored in the storage unit of the management device, the number of times of analysis of a plurality of separation columns can be managed in the management device.

(Item 4) In the management device for managing the liquid chromatograph according to any one of items 1 to 3,
The comparison display unit may present an interface for modifying the schedule when the total column analysis count for the separation column exceeds the upper limit count.

When the total number of analysis times of the separation column exceeds the upper limit number of times, it is possible to cancel execution of useless analysis processing by performing a correction operation on the schedule.

(Section 5) In the management device for managing the liquid chromatograph according to Section 4,
The interface for the correction operation may include an interface for collectively deleting from the schedule the analysis methods associated with the separation columns for which the column total analysis count exceeds the upper limit count.

Since analysis methods related to separation columns exceeding the upper limit number of times can be collectively deleted, convenience for the operator is improved.

(Section 6) A method of managing a liquid chromatograph according to another aspect includes:
obtaining the analysis times of the separation column;
obtaining a scheduled number of runs for the separation column based on a scheduled run method;
adding the number of analyzes and the scheduled number of analyses;
comparing the column total number of analyzes and the upper limit number of times calculated by adding the number of analyzes and the scheduled number of analyses;
and displaying a warning when the total column analysis count for the separation column exceeds the upper limit count.

(Section 7) A program for managing a liquid chromatograph according to another aspect,
a process of obtaining the number of analyzes of the separation column;
obtaining a scheduled number of runs for the separation column based on a scheduled run method;
a process of adding the number of times of analysis and the number of times of scheduled analysis;
a process of comparing the total number of column analyzes and the upper limit number of times calculated by adding the number of analyzes and the scheduled number of analyses;
When the total number of times of column analysis for the separation column exceeds the upper limit number of times, the computer is caused to execute a process of displaying a warning.

Claims (6)

an analysis count acquisition unit that acquires the analysis count for each of the plurality of separation columns;
a scheduled number acquisition unit that acquires a scheduled number of times of analysis for each of the plurality of separation columns based on a scheduled analysis method;
an addition unit that adds the number of times of analysis and the number of times of scheduled analysis for each of the plurality of separation columns ;
For each of the plurality of separation columns, the total number of column analyzes calculated by the addition unit is compared with the upper limit number of times, and if there is a separation column in which the total number of column analyzes exceeds the upper limit number of times, the separation exceeds the upper limit number of times. and a comparison display unit that displays a warning about the column,
When there is a separation column in which the total number of times of column analysis exceeds the upper limit number of times among the plurality of separation columns, the comparison display unit presents an interface for modifying the schedule together with the warning display. , a management device for managing a liquid chromatograph, wherein the schedule associated with a separation column exceeding the upper limit number of times is identified and displayed in the interface for the corrective operation . 2. The management device for managing a liquid chromatograph according to claim 1, wherein said analysis frequency acquisition unit acquires said analysis frequency from a column management unit attached to each of said plurality of separation columns. 2. The management device for managing a liquid chromatograph according to claim 1, wherein said number-of-analyses acquisition unit acquires said number of analyzes from a storage unit of said management device. 2. The liquid chromatograph according to claim 1, wherein the correction operation interface includes an interface for collectively deleting from the schedule the analysis methods related to the separation column for which the column total analysis count exceeds the upper limit count. management device. obtaining a run count for each of a plurality of separation columns;
obtaining a scheduled number of runs for each of the plurality of separation columns based on a scheduled run method;
adding the number of analyzes and the scheduled number of analyses , for each of the plurality of separation columns ;
comparing the column total number of analyzes and the upper limit number of times calculated by adding the number of analyzes and the planned number of analyzes for each of the plurality of separation columns ;
if there is a separation column for which the total column analysis count exceeds the upper limit count, displaying a warning for the separation column exceeding the upper limit count ;
and presenting an interface for correcting the schedule together with the warning display when there is a separation column , among the plurality of separation columns, in which the total number of times of column analysis exceeds the upper limit number of times. ,
A method of managing a liquid chromatograph , wherein in the modify operation interface, the schedule involving a separation column exceeding the upper limit number of times is identified . a process of obtaining the number of analyzes for each of a plurality of separation columns;
obtaining a scheduled number of runs for each of the plurality of separation columns based on a scheduled run method;
a process of adding the number of times of analysis and the number of scheduled times of analysis for each of the plurality of separation columns ;
for each of the plurality of separation columns, a process of comparing the column total number of analyzes and the upper limit number of times calculated by adding the number of analyzes and the scheduled number of analyses;
When there is a separation column in which the total column analysis count exceeds the upper limit count, a process of displaying a warning for the separation column exceeding the upper limit count ;
a process of presenting an interface for modifying the schedule together with the warning display when there is a separation column in which the total number of times of column analysis exceeds the upper limit number of times among the plurality of separation columns; let it run,
A program for managing a liquid chromatograph , wherein the schedule involving a separation column exceeding the upper limit number of times is identified in the modify operation interface .

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