JP7210048B2 - 心臓再同期療法 - Google Patents
心臓再同期療法 Download PDFInfo
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- JP7210048B2 JP7210048B2 JP2020501562A JP2020501562A JP7210048B2 JP 7210048 B2 JP7210048 B2 JP 7210048B2 JP 2020501562 A JP2020501562 A JP 2020501562A JP 2020501562 A JP2020501562 A JP 2020501562A JP 7210048 B2 JP7210048 B2 JP 7210048B2
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- Apparatus For Radiation Diagnosis (AREA)
Description
a)患者の心臓の画像デ-タセットを受信するステップと、
b)例えば、心臓構造、梗塞ジオメトリ、冠静脈ジオメトリ、横隔神経ジオメトリ、またはそれらの組み合わせを備える画像デ-タセットの少なくとも1つから、心臓構造の3次元(3D)解剖学的モデルを形成するステップと、
c)画像デ-タセットの少なくとも1つから心筋梗塞瘢痕分布を計算するステップと、
d)例えば、好ましくは、ピ-ク歪に対応する心臓サイクル全体にわたる時間を特定することにより、心筋3D歪分析を使用して、画像デ-タセットの少なくとも1つから心臓機械的活性化デ-タを計算するステップと、
e)例えば、心内膜または心外膜の3Dジオメトリにカラ-またはグレ-値のオ-バ-レイを取得するために重ね合わせる前に、瘢痕分布に機械的活性化デ-タを重み付けすることにより、解剖学的ジオメトリおよび/または機械的活性化デ-タおよび/または梗塞瘢痕分布を含む3Dロ-ドマップモデルを取得するために、瘢痕分布と機械的活性化デ-タを3D解剖学的モデルに重ね合わせるステップと、
を備える。
-瘢痕の3D表面メッシュを提供するために心筋梗塞瘢痕をセグメント化する、または心筋梗塞瘢痕セグメンテ-ションを備えるデ-タを受信するステップ、および
-梗塞の貫壁性、心内膜の貫壁性、心外膜の貫壁性、および梗塞の均質性を重み付けすることにより、心筋の瘢痕分布を計算するステップであって、
梗塞の貫壁性が、前記梗塞を覆う前記領域内の総梗塞面積の割合として計算され、
心内膜貫壁性が、前記心内膜境界からの距離値で重み付けされた前記梗塞貫壁性として計算され、
前記心外膜の貫壁性が、是心外膜境界からの距離値で重み付けされた前記梗塞の貫壁性であり、そして
前記梗塞の均一性が、前記検出された梗塞の形態素近似演算子によって囲まれた前記領域に関連する前記検出された梗塞の領域として計算される、
ステップを備える。
i)短軸シネMRI画像シ-ケンスと長軸シネMRI画像シ-ケンス内でLV心筋をセグメント化するステップと、
ii)ステップi)でセグメント化された心筋の変形の3D変位フィ-ルドを計算して3D歪を計算するステップと、
iii)ステップii)で計算された前記3D歪に基づいて、前記心臓の前記LV心内膜またはLV心外膜の3Dモデルを生成するステップと
を備える。
i)非侵襲的3次元解剖学的画像生成に基づいて、前記心臓の様々な部分の3Dモデルを生成するステップと、
ii)非侵襲的3次元解剖学的画像生成に基づいて、前記心臓の機械的活性化の3Dモデルを生成するステップと、
iii)ステップi)の前記3Dモデルをステップii)の前記3Dモデルに登録して、3Dロ-ドマップモデルを形成するステップと、
iv)ステップiii)の前記形成された3Dロ-ドマップモデルを使用して、前記CRT植込み手順中にペ-スメ-カリ-ドの配置をユ-ザにガイドするステップ
を備える。
時間の経過とともに複数の画像フレ-ムで構成されるX線画像デ-タセットを受信するステップ、そして
前記CRT植込み手順中に前記ペ-スメ-カリ-ドを配置する際に前記ユ-ザをガイドするために使用するために、iii)で形成した前記3Dロ-ドマップモデルを前記X線画像デ-タセットに登録するステップ、
を備える。
(u,v)-2D画像座標;
(x,y,z)-変換された3D座標;
(Px,Py,Pz)-DICOMから取得した画像位置;
(Ux,y,z,Vx,y,z)-DICOMから取得した画像の向き;
(Δu,Δv)-DICOMから取得されたピクセル間隔
Claims (20)
- 以下のステップを実行するプロセッサを備える、心臓再同期療法(CRT)のガイダンスを提供する医療機器の作動方法であって、
a)前記プロセッサが、患者の心臓の画像データセットを受信するステップ(101)と、
b)前記プロセッサが、前記画像データセットの少なくとも1つから心臓構造の三次元(3D)解剖学的モデルを形成するステップ(102)と、
c)前記プロセッサが、前記画像データセットの少なくとも1つを使用して心筋梗塞瘢痕分布を計算するステップ(103)と、
d)前記プロセッサが、前記画像データセットの少なくとも1つを使用して心臓の機械的活性化データを計算するステップ(104)と、
e)前記プロセッサが、解剖学的ジオメトリ、機械的活性化データ、および瘢痕分布を含む3Dロードマップモデルを得るために、前記3D解剖学的モデルに前記瘢痕分布と前記機械的活性化データを重ね合わせるステップ(105)と、
f)前記プロセッサが、前記得られた3Dロードマップモデルを使用して心臓再同期療法(CRT)のガイダンスを提供するステップ
を備え、
ステップc)の前記計算が、
前記プロセッサが、瘢痕の3D表面メッシュを提供するために心筋梗塞瘢痕をセグメント化するまたは心筋梗塞瘢痕セグメンテーションを含むデータを受信するステップ、および
前記プロセッサが、梗塞の貫壁性、心内膜の貫壁性、心外膜の貫壁性および梗塞の均質性に重み付けすることにより、心筋の瘢痕分布を計算するステップであって、
梗塞の貫壁性が、梗塞をカバーする領域内の総梗塞面積の割合として計算され、
心内膜の貫壁性が、心内膜境界からの距離値で重み付けされた前記梗塞の貫壁性として計算され、
前記心外膜の貫壁性が、心外膜の境界からの距離値により重み付けされた前記梗塞の貫壁性であり、
梗塞の均一性が、検出された梗塞の形態素近似演算子によって囲まれた領域に関連する検出された梗塞の領域として計算される、
ステップ
を備える、医療機器の作動方法。 - 前記瘢痕分布が、心内膜または心外膜の3Dジオメトリ上のカラーまたはグレー値のオーバーレイを得るために重ね合わせる前に、前記機械的活性化データで重み付けされる、請求項1に記載の作動方法。
- 前記3D解剖学的モデルが、心臓構造、梗塞ジオメトリ、冠静脈ジオメトリ、横隔神経ジオメトリまたはそれらの組み合わせからなる群から選択される情報を備える、請求項1または2に記載の作動方法。
- ステップd)の前記計算が、心筋の3D歪分析を使用して機械的活性化遅延を計算することを備える、請求項1-3の何れか1項に記載の作動方法。
- 機械的活性化遅延が、ピーク歪に対応する心周期全体にわたる時間を特定することにより計算される、請求項4に記載の作動方法。
- 最新の機械的活性化を経験する前記心臓のセグメントまたはゾーンが、前記3D解剖学的モデル上で概説されるように配置されそして提示され、前記最新の機械的活性化を経験する前記セグメントまたはゾーンが、心臓再同期療法における左心室での最適なペースメーカリードの位置決めのための候補セグメントまたはゾーンである、請求項1-5の何れか1項に記載の作動方法。
- 最新の機械的活性化を経験している前記心臓の梗塞のないセグメントまたはゾーンが、前記3D解剖学的モデルで概説されるように位置付けられそして提示され、前記最新の機械的活性化を経験している前記梗塞のないセグメントまたはゾーンが、心臓再同期療法における最適なペースメーカリードのポジショニングのための候補セグメントまたはゾーンである、請求項1-6の何れか1項に記載の作動方法。
- 前記形態素近似演算子が、コード(703)内の前記梗塞領域の分割を作動させ、そして斑状梗塞領域(402)を定義するコード(706、707)間の非梗塞領域を検出するように構成されている、請求項1-7の何れか1項に記載の作動方法。
- 前記3Dロードマップモデルが、心筋瘢痕のない、最新の電気的活性化を有する冠静脈上に位置する領域を、最適な左心室リード位置(単数または複数)として識別する、請求項1-8の何れか1項に記載の作動方法。
- 前記プロセッサが、3D冠静脈の解剖学的構造および電気的活性化タイミングを含む電気解剖学的マッピング(EAM)モデルを受信するステップと、
前記プロセッサが、前記3DロードマップモデルをEAMモデルに登録して、最適な左心室リード位置を決定するステップとを、
さらに、備える、請求項1-9の何れか1項に記載の作動方法。 - 前記プロセッサが、患者固有のX線画像データを受信するステップと、
前記プロセッサが、前記3Dロードマップモデルを前記X線画像データに登録して、1つまたは複数の最適な左心室誘導位置の概要を示すステップとを、
さらに、備える、請求項1-10の何れか1項に記載の作動方法。 - コンピューティングデバイスによって実行されると、コンピューティングデバイスに請求項1-11の何れか1項に記載の作動方法を実行させる命令を格納している非一時的コンピュータ可読媒体。
- 患者の前記心臓の画像データセットを得るための装置であって、心臓再同期療法におけるガイダンスのための3Dロードマップを決定するために請求項1―12の何れか1項に記載の作動方法を実行するように構成されているデータ処理モジュールを備える、装置。
- 前記装置が、シネ-MRI、遅延造影、冠状動脈MRAのデータセットを得るように構成されているMRI装置であることを特徴とする、請求項13に記載の装置。
- さらに、造影剤ありまたはなしでX線静脈造影図を得るように構成されているX線装置を組み合わせて備え、前記データ処理モジュールが、ペースメーカリードの配置を支援するための3Dロードマップモデルを計算するように構成されている、請求項14に記載の装置。
- ステップd)における前記計算が、
i)前記プロセッサが、短軸シネMRI画像シーケンスと長軸シネMRI画像シーケンス内でLV心筋をセグメント化するステップと、
ii)前記プロセッサが、ステップi)でセグメント化された心筋の変形の3D変位フィールドを計算することにより3D歪を計算するステップと、
iii)前記プロセッサが、ステップii)で計算された前記3D歪に基づいて、前記心臓のLV心内膜またはLV心外膜の3Dモデルを生成するステップと、
を備える、請求項1に記載の作動方法。 - ステップiii)の前記生成において、前記心臓の前記機械的活性化が、機械的活性化を心筋瘢痕分布により重み付けることにより、前記3Dモデルの表面上で色分けされる、請求項16に記載の作動方法。
- 以下のステップを実行するプロセッサを備える、CRT植込み手順中にユーザにガイダンスを提供する医療機器の作動方法であって、
i)前記プロセッサが、非侵襲的な3次元解剖学的画像生成に基づいて、心臓の様々な部分の3Dモデルを生成するステップと、
ii)前記プロセッサが、非侵襲的な3次元解剖学的画像生成に基づいて、前記心臓の機械的活性化の3Dモデルを生成するステップと、
iii)前記プロセッサが、ステップi)の前記3Dモデルをステップii)の前記3Dモデルに登録して、3Dロードマップモデルを形成するステップと、
iv)前記プロセッサが、ステップiii)の前記形成された3Dロードマップモデルを使用して、前記CRT植込み手順中にペースメーカリードの配置をユーザにガイドするステップと、
v)前記プロセッサが、時間の経過とともに複数の画像フレームにより構成されるX線画像データセットを受信するステップと、
vi)前記プロセッサが、前記CRT植込み手順中に前記ペースメーカリードを配置する際に前記ユーザをガイドするために使用される前記X線画像データセットに、ステップiii)で形成された3Dロードマップモデルを登録するステップと、
を備える、医療機器の作動方法。 - ステップi)における前記心臓の異なる部分の3Dモデルを生成することが、LV心内膜、心外膜、および心筋瘢痕の3Dモデルを生成することを含む、請求項18に記載の作動方法。
- 心内膜3Dジオメトリまたは心外膜3Dジオメトリにカラーまたはグレー値オーバーレイとして重ね合わせる前に、前記心筋瘢痕が、前記機械的活性化により重み付けされる、請求項19に記載の作動方法。
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