JP7153778B2 - Concentrated cosmetic emulsifying matrix and its preparation and use - Google Patents

Description

The present invention belongs to the field of cosmetics, specifically to a cosmetic concentrated emulsifying matrix and its preparation method and use, especially to a cosmetic concentrated emulsifying matrix with emollient effect and its preparation method and use.

In general, the development of cosmetics is based on the product planning to determine each formula and manufacturing method, and based on that to select mass-produced devices and determine manufacturing standards. Currently, the cosmetics industry is largely divided into two types. One is mass-produced clean care cosmetics (shampoos, shower gels, etc.) in a small number of categories, and the other is cosmetics (skin care products, color makeup, etc.) produced in large quantities in small quantities. Unlike low-volume production in many categories, in the case of mass production in a few categories, formulations and preparation methods are generally developed on the premise of manufacturing fully automatic devices, and products that are produced in small quantities in many categories are generally Due to the high price level and the diversity of product requirements, it is possible to form design formulations after considering the selection of concept ingredients and the diversity of matrix formulations at the development stage, and then consider device selection, etc. However, the development period is relatively long. Also, the large number of categories and often different dosage forms increase the devices and manufacturing time required for mass production. Therefore, developing a highly versatile matrix formulation that is suitable for common dosage forms (skin lotion, milky lotion, etc.) and then diluting it before use contributes to improving the efficiency of formulation design and mass production. do.

CN111991268A discloses a cosmetic matrix with skin repair effect, the ingredients of which are Oligopeptide-3 1-5 parts by weight, Tripeptide-1 1-5 parts by weight, Mannitol 10-20 parts by weight, Trehalose 10-20 parts by weight. 20 parts by weight, 10-20 parts by weight of dextran, 15-25 parts by weight of auxiliaries, the balance being water, the present invention further relates to a method for preparing the above-mentioned cosmetic matrix, and the present invention also relates to a cosmetic product having a skin repair effect. Regarding, the cosmetic matrix with skin repair effect according to the present invention has skin repair effect and can be prepared into different cosmetics such as lotion, milky lotion and cream.

CN112006939A discloses a cosmetic matrix with skin lightening effect, the ingredients of which are 1-5 parts by weight nicotinamide, 1-5 parts by weight glutathione, 15-25 parts by weight dextran, 15-25 parts by weight mannitol parts by weight, 15-25 parts by weight of trehalose, 10-20 parts by weight of auxiliaries, the balance being water, the present invention further relates to a method for preparing the above-mentioned cosmetic matrix, the present invention also relates to a skin lightening effect The cosmetic matrix having the effect of lightening the skin color according to the present invention has the effect of lightening the skin color without damaging the skin, and is used in lotions, milky lotions, creams, etc. It can be prepared into different cosmetics.

At present, the diversification of product requirements causes the problem of long development period of cosmetics. Therefore, it is an urgent issue to provide a cosmetic matrix that has high versatility and improves the efficiency of formulation design and mass production.

For the shortcomings of the prior art, the object of the present invention is to provide a cosmetic concentrated emulsifying matrix and its preparation method and use, especially to provide a cosmetic concentrated emulsifying matrix with emollient effect and its preparation method and use. The cosmetic concentrated emulsifying matrix according to the present invention has high versatility, and the prepared cosmetic has good emollient effect and good stability, and improves the efficiency of formulation design and mass production.

In order to achieve the object of the present invention, the present invention has taken the following technical solutions.
In a first aspect, the present invention provides a concentrated cosmetic emulsifying matrix, said cosmetic emulsifying matrix comprising 20-30 parts by weight of butanediol, 16-20 parts by weight of glycerin, 1-3 parts by weight of erythritol, 3 parts by weight of behenyl alcohol. ~7 parts by weight, stearyl alcohol 1.5-3.5 parts by weight, ester oil 3-7 parts by weight, hydrocarbons 5-10 parts by weight, PEG-60 (hydrogenated castor oil) 3-7 parts by weight, stearic acid Contains 1.5-3.5 parts by weight of glyceryl, 3-7 parts by weight of polydimethylsiloxane and 0.3-0.7 parts by weight of tocopherol acetate.

Among them, the number of butanediol parts by weight is 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 parts by weight, or 30 parts by weight, etc., the number of parts by weight of glycerin may be 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, or 20 parts by weight, etc., and the number of parts by weight of erythritol is It may be 1 part by weight, 1.5 parts by weight, 2 parts by weight, 2.5 parts by weight or 3 parts by weight, etc., and the number of parts by weight of behenyl alcohol is 3 parts by weight, 3.5 parts by weight, 4 parts by weight. , 4.5 parts by weight, 5 parts by weight, 5.5 parts by weight, 6 parts by weight, 6.5 parts by weight, or 7 parts by weight, etc., and the number of parts by weight of stearyl alcohol is 1.5 parts by weight. , 2 parts by weight, 2.5 parts by weight, 3 parts by weight or 3.5 parts by weight, etc., and the number of parts by weight of the ester oil may be 3 parts by weight, 3.5 parts by weight, 4 parts by weight, 4 parts by weight, .5 parts by weight, 5 parts by weight, 5.5 parts by weight, 6 parts by weight, 6.5 parts by weight or 7 parts by weight, etc., where the number of parts by weight of hydrocarbons is 5 parts by weight, 6 parts by weight , 7 parts by weight, 8 parts by weight, 9 parts by weight or 10 parts by weight, etc., and the number of parts by weight of PEG-60 is 3 parts by weight, 3.5 parts by weight, 4 parts by weight, 4.5 parts by weight parts, 5 parts by weight, 5.5 parts by weight, 6 parts by weight, 6.5 parts by weight or 7 parts by weight, etc., and the number of parts by weight of glyceryl stearate is 1.5 parts by weight, 2 parts by weight , 2.5 parts by weight, 3 parts by weight, or 3.5 parts by weight, etc., and the number of parts by weight of polydimethylsiloxane is 3 parts by weight, 3.5 parts by weight, 4 parts by weight, 4.5 parts by weight. parts, 5 parts by weight, 5.5 parts by weight, 6 parts by weight, 6.5 parts by weight, or 7 parts by weight, etc., and the number of parts by weight of tocopherol acetate is 0.3 parts by weight, 0.4 parts by weight. parts, 0.5 parts by weight, 0.6 parts by weight or 0.7 parts by weight, etc., but are not limited to the above listed numbers and other unlisted Numerical values are applicable as well.

The above-mentioned concentrated cosmetic emulsified matrix with the specific ingredients and their blending ratio is prepared by selecting and compounding glycerin, ester oil, PEG-60 and polydimethylsiloxane to achieve a remarkable emollient effect. It has high versatility as a suitable formulation, and improves the efficiency of formulation design and mass production. It can improve the stability of cosmetics.

Glycerin, also called glycerol, can be used as a softener, moisturizer, makeup remover and lubricant. Glycerin has a water-absorbing effect, and is often used in moisturizing skin care products to absorb water molecules in the air and keep the stratum corneum covered with it moist.

PEG-60 is used in cosmetics as a solvent, O/W ionic emulsifier and surfactant, and the addition of this ingredient to products provides a smooth feel.

Polydimethylsiloxane, also known as dimethicone, has good lubricating performance, gloss, anti-ultraviolet radiation performance, antistatic performance, air permeability, long fragrance retention period, high stability, chemical inertness, and other cosmetic properties. It does not have any adverse effects on the ingredients, especially on the active ingredients, has good compatibility, is non-toxic, odorless and tasteless, does not cause skin irritation and allergies, and is highly safe.

Preferably, said cosmetic concentrated emulsifying matrix comprises 23-27 parts by weight butanediol, 17-19 parts by weight glycerin, 1-1.5 parts by weight erythritol, 4-6 parts by weight behenyl alcohol, 2-3 parts by weight stearyl alcohol, ester 4-6 parts by weight of oil, 7-8 parts by weight of hydrocarbons, 4-6 parts by weight of PEG-60, 2-3 parts by weight of glyceryl stearate, 4-6 parts by weight of polydimethylsiloxane and 0.4-0.4 parts by weight of tocopheryl acetate. Contains 6 parts by weight.

Preferably, said cosmetic concentrate emulsifying matrix further comprises water.

Preferably, the ester oil contains any one or at least two of glyceryl stearate, myristyl myristate, caprylic/capric triglyceryl, ethylhexyl palmitate, dicaprylyl carbonate, decyl cocoate or cetyl palmitate. including combinations such as glyceryl stearate and myristyl myristate, caprylic/capric triglyceryl carbonate and dicaprylyl carbonate, or ethylhexyl palmitate and dicaprylyl carbonate, etc., such as those listed above. The combination is not limited and other non-listed combinations within the above combination range are applicable as well.

Preferably, said hydrocarbon comprises any one or a combination of at least two of squalane, isododecane or isohexadecane, such as a combination of squalane and isododecane, isododecane and isohexadecane, or squalane and isohexadecane. etc., but are not limited to the above listed combinations, and other unlisted combinations within the above combination range are applicable as well.

In a second aspect, the present invention provides a method for preparing the above-described cosmetic concentrate emulsifying matrix, said method comprising:
butanediol, glycerin and erythritol are mixed to obtain a mixture A, behenyl alcohol, stearyl alcohol, ester oil, hydrocarbons, hydrogenated castor oil, glyceryl stearate, polydimethylsiloxane and tocopherol acetate are mixed and heated to form a mixture step (1) of obtaining B;
and step (2) of mixing mixture A obtained in step (1) with mixture B, heating and then cooling to obtain said cosmetic concentrated emulsifying matrix.

The above preparation method is simple and easy to operate, and can quickly and efficiently prepare the cosmetic concentrated emulsified matrix.

Preferably, mixing butanediol, glycerin and erythritol according to step (1) further comprises mixing with water.

Preferably, step (1) is heated to a temperature of 83-87°C.

Preferably, in step (2), heat to a temperature of 83-87°C.

Wherein, in step (1), the temperature can be heated to 83°C, 84°C, 85°C, 86°C or 87°C, etc.; , 86° C. or 87° C., etc., but are not limited to the values listed above, and other unlisted values within the ranges of the above values are applicable as well.

As a preferred technical solution of the present invention, the preparation method comprises:
Butanediol, glycerin, erythritol and water are mixed to obtain mixture A, and behenyl alcohol, stearyl alcohol, ester oil, hydrocarbons, hydrogenated castor oil, glyceryl stearate, polydimethylsiloxane and tocopheryl acetate are mixed to form 83- heating to 87° C. to obtain a mixture B (1);
mixing the mixture A obtained in step (1) with mixture B and heating to 83-87° C. and then cooling to obtain said cosmetic concentrated emulsifying matrix (2).

In a third aspect, the present invention further provides the use of a cosmetic concentrate emulsifying matrix as described above in the preparation of a cosmetic product.

Compared with the prior art, the present invention has the following beneficial effects.
The present invention selects and prepares raw materials in a specific combination and its blending ratio to obtain a cosmetic concentrated emulsified matrix, and selects glycerin, ester oil, PEG-60 and polydimethylsiloxane for composite preparation. , which has a remarkable emollient effect, is highly versatile as a general formulation of cosmetic emulsifying matrix, improves the efficiency of formulation design and mass production, at the same time, by preparing said cosmetic concentrated emulsifying matrix before preparing cosmetics. , some of the cosmetic raw materials can be premixed to improve the stability of the prepared cosmetic.

Hereinafter, the technical solution of the present invention will be further described with reference to the preferred embodiments of the present invention in order to further describe the technical means and effects thereof adopted in the present invention. is not limited to

In the following Examples, Comparative Examples and Use-Examples, the polydimethylsiloxane was purchased from Dow Corning, model number BELSIL® DM 350;
The alkyl acrylates/C10-30 alkanol acrylate crosspolymer was purchased from Lubrizol, model number was CARBOPOL® ULTREZ 21 POLYMER.

In the following use examples and comparative use examples, the source of the concentrated lotion matrix is referred to the patent application entitled "Concentrated lotion matrix and its method of preparation and use" filed on the same date as this application by the applicant, and the ingredients and The compounding ratio was as follows.

Example 1
This example provides a cosmetic concentrated emulsifying matrix, the ingredients and blending ratios of which are as follows.

The preparation method was as follows.
(1) Mixing butanediol, glycerin, erythritol and water to obtain a mixture A, mixing behenyl alcohol, stearyl alcohol, ester oil, hydrocarbons, hydrogenated castor oil, glyceryl stearate, polydimethylsiloxane and tocopheryl acetate; to 85° C. to obtain a mixture B,
(2) Mixture A obtained in step (1) was mixed with mixture B and heated to 85° C. and then cooled to obtain said cosmetic concentrated emulsified matrix.

Example 2
This example provides a cosmetic concentrated emulsifying matrix, the ingredients and blending ratios of which are as follows.

The preparation method was as follows.
(1) Mixing butanediol, glycerin, erythritol and water to obtain a mixture A, mixing behenyl alcohol, stearyl alcohol, ester oil, hydrocarbons, hydrogenated castor oil, glyceryl stearate, polydimethylsiloxane and tocopheryl acetate; to 83° C. to obtain a mixture B,
(2) Mixture A obtained in step (1) was mixed with mixture B and heated to 83° C. and then cooled to obtain said cosmetic concentrated emulsified matrix.

Example 3
This example provides a cosmetic concentrated emulsifying matrix, the ingredients and blending ratios of which are as follows.

The preparation method was as follows.
(1) Mixing butanediol, glycerin, erythritol and water to obtain a mixture A, mixing behenyl alcohol, stearyl alcohol, ester oil, hydrocarbons, hydrogenated castor oil, glyceryl stearate, polydimethylsiloxane and tocopheryl acetate; to 87° C. to obtain a mixture B,
(2) Mixture A obtained in step (1) was mixed with mixture B and heated to 87° C. and then cooled to obtain said cosmetic concentrated emulsified matrix.

Example 4
This example provides a cosmetic concentrated emulsifying matrix, the ingredients and blending ratios of which are as follows.

The preparation method was consistent with Example 1.

Example 5
This example provides a cosmetic concentrated emulsifying matrix, the ingredients and blending ratios of which are as follows.

The preparation method was consistent with Example 1.

Comparative example 1
This comparative example provides a cosmetic concentrated emulsifying matrix, and its components and blending ratios are as follows.

The preparation method was consistent with Example 1.

Comparative example 2
This comparative example provides a cosmetic concentrated emulsifying matrix, and its components and blending ratios are as follows.

The preparation method was consistent with Example 1.

Comparative example 3
This comparative example provides a cosmetic concentrated emulsifying matrix that does not contain glycerin as an ingredient and that the reduced portion is allocated to tri(caprylic/capric)glyceryl, PEG-60 and polydimethylsiloxane in proportion. In addition, otherwise consistent with Example 1.
See Example 1 for the preparation method.

Comparative example 4
This comparative example provides a cosmetic concentrated emulsifying matrix that does not contain tri(caprylic/capric)glyceryl as an ingredient and assigns the reduced portion to glycerin, PEG-60 and polydimethylsiloxane in proportion. In addition, otherwise consistent with Example 1.
See Example 1 for the preparation method.

Comparative example 5
This comparative example provides a cosmetic concentrated emulsifying matrix, the ingredients of which do not contain PEG-60, and the proportion of which is reduced is allocated to tri(caprylic/capric)glyceryl, glycerin and polydimethylsiloxane in proportion. In addition, otherwise consistent with Example 1.
See Example 1 for the preparation method.

Comparative example 6
This comparative example provides a cosmetic concentrate emulsifying matrix, the ingredients of which do not contain polydimethylsiloxane, and the proportion of which is reduced is allocated to tri(caprylic/capric)glyceryl, PEG-60 and glycerin. In addition, otherwise consistent with Example 1.
See Example 1 for the preparation method.

Usage example 1
This use example provides a cream, and its components and blending ratios are as follows.

The preparation method was as follows.
(1) carbomer, acrylic acid (alkyl)s/C10-30 alkanol acrylate crosslinked polymer and water are mixed and stirred to obtain a mixture A,
(2) mixing the mixture A obtained in step (1) with a concentrated lotion matrix and stirring to obtain a mixture B;
(3) Heating the mixture B obtained in step (2) and the cosmetic concentrated emulsifying matrix according to Example 1 respectively to 85°C, then mixing and stirring until emulsified, continuing to stir and cooling to 45°C or less. Then, aminomethylpropanol was added and stirred for 15 minutes to obtain the cream.

Usage examples 2 to 5
Use Examples 2-5 each provide a cream in which, in addition to replacing the cosmetic emulsifying matrix concentrate according to Example 1 with an equal amount of the emulsifying cosmetic concentrate according to Examples 2-5 respectively, in their ingredients, Others were consistent with use example 1.
Refer to Use Example 1 for the preparation method.

Comparative use examples 1 to 6
Comparative Use Examples 1 to 6 each provide a cream, in addition to replacing the cosmetic emulsifying matrix concentrate according to Example 1 with an equal amount of the emulsifying cosmetic concentrate according to Comparative Examples 1 to 6, respectively, in their ingredients. , and others were consistent with Example 1.
Refer to Use Example 1 for the preparation method.

Comparative use example 7
In this comparative use example, a cream was provided, and its ingredients and blending ratio were as follows.

The preparation method was as follows.
(1) carbomer, acrylic acid (alkyl)s / C10-30 alkanol acrylate crosslinked polymer and a part of water are mixed and stirred to obtain a mixture A,
(2) mixing the mixture A obtained in step (1), butanediol, glycerin, erythritol, and a concentrated lotion matrix with the remaining water and stirring to obtain a mixture B;
(3) Behenyl alcohol, stearyl alcohol, tri(caprylic/capric)glyceryl, squalane, PEG-60, glyceryl stearate, polydimethylsiloxane and tocopherol acetate are mixed and heated to 85° C. to dissolve, forming mixture C. Get,
(4) Heat the mixture B obtained in step (2) and the mixture C obtained in step (3) to 85°C, then mix and stir until emulsified, continue stirring and cool to 45°C or less. Then, aminomethylpropanol was added and stirred for 15 minutes to obtain the cream.

Emollient effect test 1. Test sample and object (1) Test sample: Creams according to Use Examples 1-5 and creams according to Comparative Use Examples 1-6.
(2) Subject selection criteria: Select 40 Chinese adult women with normal skin aged 20-45 who have acute skin inflammation or other skin diseases, who have a history of allergic predisposition or cosmetic allergy. , excluded those who were pregnant or lactating.
(3) Test site: inner arm.

2. Test environment Temperature: 22°C, 11°C Humidity: 50% ± 5%, constant temperature and humidity environment with uniform light. Prior to testing, subjects were required to sit quietly in this environment for 20 minutes.

3. Test method The test method referred to T/GDCA 1-2020 “General Principles for Sensory Evaluation of Cosmetics”. Take 1 g of the test sample and apply it to a circular area with a radius of 2 cm inside the arm, and score the indicators such as texture, brightness, spreadability, moisture, thickness, smoothness, and absorbency of the test sample. The recorded results are shown in the following table.

From the above data, it can be seen that the cosmetic products prepared with the cosmetic concentrated emulsifying matrix according to the present invention by the combined preparation of glycerin, ester oil, PEG-60 and polydimethylsiloxane have a remarkable emollient effect. The emollient effect is further improved within the preferred range.

Stability Test The cream samples of Use Example 1 and Comparative Use Example 7 were left under the following conditions for 6 months, and changes in product quality, color and fragrance were observed and the results were recorded.
Condition 1 (heat resistance): 45°C constant temperature incubator Condition 2 (cold resistance): -18°C refrigerator Condition 3 (cycle): alternating high and low temperature incubator (7-day cycle)
Alternating high temperature/low temperature incubator (7-day cycle)
Condition 4 (sunshine): sunshine/ultraviolet climate incubator

The stability test results of Use Example 1 are shown in the following table.

The stability test results of Comparative Use Example 7 are shown in the following table.

From the above data, it can be seen that cosmetics prepared with the cosmetically concentrated emulsifying matrix according to the present invention have higher stability than cosmetics prepared with the initial raw materials.

Although the present invention has illustrated the cosmetic concentrated emulsifying matrix of the present invention and its method of preparation and use by the above examples, the present invention is not limited to the above examples, i.e. the present invention is practiced by the above examples. Applicant states that it does not have to. For those skilled in the art, any modification to the present invention, equivalent substitution and addition of auxiliary ingredients to each raw material of the product of the present invention, selection of specific embodiments, etc., will all fall within the protection scope and disclosure scope of the present invention. Clear.

Although the preferred embodiments of the invention have been described in detail above, the invention is not limited to the specific details of the above embodiments, and various simple modifications can be made within the spirit of the invention. and all these simple modifications fall within the protection scope of the present invention.

It should be noted that features of each of the specific techniques described in the above specific embodiments may be combined in any suitable manner, where not inconsistent, and may be variously described in the present invention to avoid unnecessary repetition. not individually describe each possible combination.

Claims (10)

20-30 parts by weight of butanediol, 16-20 parts by weight of glycerin, 1-3 parts by weight of erythritol, 3-7 parts by weight of behenyl alcohol, 1.5-3.5 parts by weight of stearyl alcohol, 3-7 parts by weight of ester oil, carbonization 5 to 10 parts by weight of hydrogen, 3 to 7 parts by weight of PEG-60, 1.5 to 3.5 parts by weight of glyceryl stearate, 3 to 7 parts by weight of polydimethylsiloxane and 0.3 to 0.7 parts by weight of tocopherol acetate. A cosmetic concentrated emulsifying matrix, characterized in that it comprises: 23-27 parts by weight of butanediol, 17-19 parts by weight of glycerin, 1-1.5 parts by weight of erythritol, 4-6 parts by weight of behenyl alcohol, 2-3 parts by weight of stearyl alcohol, 4-6 parts by weight of ester oil, 7 parts by weight of hydrocarbons ~8 parts by weight, 4-6 parts by weight of PEG-60, 2-3 parts by weight of glyceryl stearate, 4-6 parts by weight of polydimethylsiloxane and 0.4-0.6 parts by weight of tocopherol acetate. The cosmetic concentrated emulsifying matrix of claim 1. 3. The cosmetic concentrated emulsifying matrix according to claim 1 or 2, further comprising water. The ester oil contains any one of glyceryl stearate, myristyl myristate, caprylic/capric triglyceryl, ethylhexyl palmitate, dicaprylyl carbonate, decyl cocoate, or cetyl palmitate, or a combination of at least two of them. The cosmetic concentrated emulsifying matrix according to any one of claims 1 to 3, characterized in that . A cosmetic concentrated emulsifying matrix according to any one of claims 1 to 4, characterized in that said hydrocarbon comprises any one or a combination of at least two of squalane, isododecane or isohexadecane. A method for preparing a cosmetically concentrated emulsifying matrix according to any one of claims 1 to 5, comprising:
butanediol, glycerin and erythritol are mixed to obtain a mixture A, behenyl alcohol, stearyl alcohol, ester oil, hydrocarbons, hydrogenated castor oil, glyceryl stearate, polydimethylsiloxane and tocopherol acetate are mixed and heated to form a mixture step (1) of obtaining B;
(2) mixing mixture A obtained in step (1) with mixture B, heating and then cooling to obtain said cosmetic concentrate emulsification matrix. Method. 7. The method of preparing a cosmetic concentrated emulsifying matrix according to claim 6, wherein mixing butanediol, glycerin and erythritol according to step (1) further comprises mixing with water. In step (1), heating to a temperature of 83 to 87 ° C.,
Preferably, in step (2), the process is heated to a temperature of 83-87°C. Butanediol, glycerin, erythritol and water are mixed to obtain mixture A, and behenyl alcohol, stearyl alcohol, ester oil, hydrocarbons, hydrogenated castor oil, glyceryl stearate, polydimethylsiloxane and tocopheryl acetate are mixed to form 83- heating to 87° C. to obtain a mixture B (1);
and (2) mixing the mixture A obtained in step (1) with mixture B and heating to 83-87° C. and then cooling to obtain said cosmetic concentrated emulsified matrix. 9. A method for preparing a cosmetic concentrated emulsifying matrix according to any one of Items 6-8. Use of the cosmetically concentrated emulsifying matrix according to any one of claims 1-5 in the preparation of cosmetics.