JP7112414B2 - 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ - Google Patents

網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ Download PDF

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JP7112414B2
JP7112414B2 JP2019542436A JP2019542436A JP7112414B2 JP 7112414 B2 JP7112414 B2 JP 7112414B2 JP 2019542436 A JP2019542436 A JP 2019542436A JP 2019542436 A JP2019542436 A JP 2019542436A JP 7112414 B2 JP7112414 B2 JP 7112414B2
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ロスカ，ボトンド
ユエットナー，ジョゼフィーヌ
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フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

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JP2019542436A 2017-02-08 2018-02-05 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ Expired - Fee Related JP7112414B2 (ja)

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EP17155193 2017-02-08
EP17155193.0 2017-02-08
PCT/IB2018/050696 WO2018146588A1 (en) 2017-02-08 2018-02-05 Synp88, a promoter for the specific expression of genes in retinal ganglion cells

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US10941417B2 (en) 2015-04-30 2021-03-09 Friedrich Miescher Institute For Biomedical Research Promoter for the specific expression of genes in Müller cells
US10857241B2 (en) 2015-09-15 2020-12-08 Friedrich Miescher Institute For Biomedical Research Therapeutical tools and methods for treating blindness by targeting photoreceptors
WO2017064642A1 (en) 2015-10-14 2017-04-20 Fredrich Miescher Institute For Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
ES2909444T3 (es) 2015-12-03 2022-05-06 Friedrich Miescher Institute For Biomedical Res Synp159, un promotor para la expresión específica de genes en los fotorreceptores de los bastones
EP3383440B1 (en) 2015-12-03 2021-06-30 Friedrich Miescher Institute for Biomedical Research Synp162, a promoter for the specific expression of genes in rod photoreceptors
EP3383439B1 (en) 2015-12-03 2019-09-25 Friedrich Miescher Institute for Biomedical Research Synp161, a promoter for the specific expression of genes in rod photoreceptors
WO2017093934A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp160, a promoter for the specific expression of genes in rod photoreceptors
RU2766353C2 (ru) 2016-11-02 2022-03-15 Фридрих Мишер Инститьют Фор Байомедикал Рисерч Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления
WO2018146588A1 (en) * 2017-02-08 2018-08-16 Friedrich Miescher Institute For Biomedical Research Synp88, a promoter for the specific expression of genes in retinal ganglion cells
MX2020005033A (es) 2017-11-15 2020-10-28 Friedrich Miescher Institute For Biomedical Res Promotor especifico de las celulas del epitelio pigmentario retinal en primates.
SG11202005024QA (en) 2017-11-30 2020-06-29 Friedrich Miescher Institute For Biomedical Res Synpiii, a promoter for the specific expression of genes in retinal pigment epithelium
CN110857440B (zh) * 2018-08-23 2021-02-19 武汉纽福斯生物科技有限公司 重组人ⅱ型线粒体动力蛋白样gtp酶基因序列及其应用
EP3870709A1 (en) * 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes
US20210353773A1 (en) * 2018-10-25 2021-11-18 Friedrich Miescher Institute For Biomedical Research Synp194 (prob15), a promoter for the specific expression of genes in retinal ganglion cells
WO2022028472A1 (en) * 2020-08-05 2022-02-10 Hangzhou Jiayin Biotech Ltd. Nucleic acid constructs and uses thereof for treating spinal muscular atrophy
TW202323529A (zh) 2021-10-18 2023-06-16 美商再生元醫藥公司 包括腺病毒相關病毒聚核苷酸的真核細胞
CN117625619B (zh) * 2023-12-05 2024-11-12 云舟生物科技(广州)股份有限公司 核酸分子及其作为特异启动子的应用

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US11371060B2 (en) 2022-06-28
US20200277626A1 (en) 2020-09-03
US20220267800A1 (en) 2022-08-25
WO2018146588A8 (en) 2019-09-26
CN110392582A (zh) 2019-10-29
EP3579884A1 (en) 2019-12-18
JP2020506710A (ja) 2020-03-05

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