JP7112414B2 - 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ - Google Patents

網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ Download PDF

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JP7112414B2
JP7112414B2 JP2019542436A JP2019542436A JP7112414B2 JP 7112414 B2 JP7112414 B2 JP 7112414B2 JP 2019542436 A JP2019542436 A JP 2019542436A JP 2019542436 A JP2019542436 A JP 2019542436A JP 7112414 B2 JP7112414 B2 JP 7112414B2
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ロスカ，ボトンド
ユエットナー，ジョゼフィーヌ
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フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

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JP2019542436A 2017-02-08 2018-02-05 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターｓｙｎｐ８８ Expired - Fee Related JP7112414B2 (ja)

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EP17155193.0 2017-02-08
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PCT/IB2018/050696 WO2018146588A1 (en) 2017-02-08 2018-02-05 Synp88, a promoter for the specific expression of genes in retinal ganglion cells

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JP2011516091A (ja) 2008-04-18 2011-05-26 ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ 失明の治療のための新規な治療用ツールおよび方法
ES2747433T3 (es) 2015-04-30 2020-03-10 Friedrich Miescher Institute For Biomedical Res Promotor para la expresión específica de genes en células de Müller
WO2017046084A1 (en) 2015-09-15 2017-03-23 Friedrich Miescher Institute For Biomedical Research Novel therapeutical tools and methods for treating blindness by targeting photoreceptors
EP3362101B1 (en) 2015-10-14 2021-05-19 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
BR112018011059A2 (pt) 2015-12-03 2018-11-21 Friedrich Miescher Institute For Biomedical Research synp161, um promotor para a expressão específica de genes em fotoreceptores de haste
WO2017093934A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp160, a promoter for the specific expression of genes in rod photoreceptors
JP7075341B2 (ja) 2015-12-03 2022-05-25 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ ＳｙｎＰ１６２、桿体光受容器における遺伝子の特異的発現のためのプロモーター
US10995344B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SYNP159, a promoter for the specific expression of genes in rod photoreceptors
CA3042197A1 (en) 2016-11-02 2018-05-11 Friedrich Miescher Institute For Biomedical Research Synp198, a promoter for the specific expression of genes in direction selective retinal ganglion cells
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JP2021503934A (ja) 2017-11-30 2021-02-15 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ 網膜色素上皮中の遺伝子の特異的発現のためのプロモーターＳｙｎＰＩＩＩ
CN110857440B (zh) * 2018-08-23 2021-02-19 武汉纽福斯生物科技有限公司 重组人ⅱ型线粒体动力蛋白样gtp酶基因序列及其应用
US20210353773A1 (en) * 2018-10-25 2021-11-18 Friedrich Miescher Institute For Biomedical Research Synp194 (prob15), a promoter for the specific expression of genes in retinal ganglion cells
US20210388385A1 (en) * 2018-10-25 2021-12-16 Friedrich Miescher Institute For Biomedical Research Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes
WO2022028472A1 (en) * 2020-08-05 2022-02-10 Hangzhou Jiayin Biotech Ltd. Nucleic acid constructs and uses thereof for treating spinal muscular atrophy
AU2022373653A1 (en) 2021-10-18 2024-05-02 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides
CN117625619B (zh) * 2023-12-05 2024-11-12 云舟生物科技(广州)股份有限公司 核酸分子及其作为特异启动子的应用

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CN111726985B (zh) 2017-11-15 2022-06-10 弗里德里克·米谢尔生物医学研究所 灵长类动物视网膜色素上皮细胞特异性启动子
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CN110392582A (zh) 2019-10-29
JP2020506710A (ja) 2020-03-05
EP3579884A1 (en) 2019-12-18
US20200277626A1 (en) 2020-09-03
WO2018146588A1 (en) 2018-08-16
US11371060B2 (en) 2022-06-28
US20220267800A1 (en) 2022-08-25

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