JP7069920B2 - Biometric information measuring device and biometric information measuring program - Google Patents

Description

The present invention relates to a biometric information measuring device and a biometric information measuring program.

Patent Document 1 describes an air flow signal indicating a time change of a breathing air flow, a signal acquisition unit for acquiring an oxygen saturation signal indicating a time change of oxygen saturation, a first time in the air flow signal, and the first time. A circulation time measuring device having a circulation time calculation unit for measuring the oxygen circulation time of blood based on the time difference from the second time in the oxygen saturation signal indicating an increase in oxygen saturation corresponding to resumption of breathing at one time. Is disclosed.

Re-table 2015-190413

Conventionally, the development of a measurement method for measuring biological information using the oxygen cycle time, which indicates the time required for oxygen taken into the body to be transported to a predetermined site, has been promoted.

Oxygen circulation time is estimated from, for example, oxygen saturation, but when measuring oxygen circulation time using oxygen saturation, the subject is measured so that an increase in oxygen saturation due to oxygen taken into the body can be detected. It is preferable to hold the breath and reduce the oxygen saturation in advance before measuring the oxygen circulation time.

However, if the actual respiratory arrest period in the subject is too short, the amount of change in oxygen saturation tends to be small, which may make it difficult to measure the oxygen cycle time. In addition, it is easier to measure the oxygen circulation time because the amount of change in oxygen saturation tends to increase as the period of respiratory arrest increases, but if the period of respiratory arrest is longer than necessary, breathing is impossible. Due to the effect of trying to hold back, for example, the pulse wave or the like may show an unusual value, and the oxygen circulation time may not be measured correctly.

INDUSTRIAL APPLICABILITY According to the present invention, the oxygen circulation time can be measured in a state where the variation in the period of respiratory arrest in the subject is suppressed, as compared with the case where the subject during respiratory arrest is not notified of the time to resume breathing. It is an object of the present invention to provide a biometric information measuring device and a biometric information measuring program.

In order to achieve the above object, the invention of the biometric information measuring device according to claim 1 notifies the subject who is in respiratory arrest to resume breathing when the prescribed time for defining the respiratory arrest period is reached. And a measuring means for measuring the oxygen circulation time, which represents the time until the oxygen taken into the body of the person to be measured reaches a predetermined site by resuming the breathing of the person to be measured. The notification means includes a detection means for detecting the presence or absence of breathing of the person to be measured, and the notification means has reached the specified time since the detection means detects the stop of breathing of the person to be measured. In that case, the resumption notice is notified .

According to the second aspect of the present invention, the measuring means measures the oxygen cycle time when the detection means detects the respiration of the person to be measured after the notification of the restart notification by the notification means.

According to the third aspect of the present invention, the detection means detects the presence or absence of respiration of the person to be measured by the air flow in the nose and mouth of the person to be measured.

According to the fourth aspect of the present invention, the detection means detects the presence or absence of respiration of the subject by the change in the amplitude of the pulse wave in the subject.

According to the fifth aspect of the present invention, the detection means detects the presence or absence of breathing of the person to be measured by the movement of the chest of the person to be measured.

The invention according to claim 6 comprises a notification means for notifying a measured person who is in a respiratory arrest to resume breathing when a specified time for determining a respiratory arrest period is reached, and a breathing of the measured person. A measuring means for measuring the oxygen circulation time, which represents the time until the oxygen taken into the body of the person to be measured reaches a predetermined site, and the biological information of the person to be measured or the person to be measured. The information is notified by the operation of the measurer who measures the measurement, and includes a reception means for receiving the information indicating that the person to be measured has stopped breathing, and the notification means is the reception means for the person to be measured. When the elapsed time from receiving the information indicating that the breathing has stopped reaches the specified time, the resumption notification is notified.

The invention according to claim 7 measures the oxygen cycle time when the measuring means receives information indicating that the person to be measured has started breathing by the receiving means after the notification of the resumption notice.

According to the eighth aspect of the present invention, the measuring means has the oxygen cycle when the period from the notification of the resumption notification by the notification means to the resumption of respiration by the subject is within a predetermined period. Measure the time.

The invention according to claim 9 is the oxygen cycle in which the measuring means exceeds a predetermined period from the notification of the resumption notification by the notification means to the resumption of respiration by the person to be measured. Stop measuring time.

The invention according to claim 10 comprises a notification means for notifying a measured person who is in a respiratory arrest to resume breathing when a specified time for determining a respiratory arrest period is reached, and a breathing of the measured person. The measuring means for measuring the oxygen circulation time, which represents the time until the oxygen taken into the body of the person to be measured reaches a predetermined site, is provided, and the notification means is provided by the person to be measured. The person to be measured is notified to stop breathing, and when the elapsed time from the notification of the stop notification reaches the specified time, the measurement means notifies the resumption notice. The oxygen circulation time is measured after a predetermined time has elapsed after the resumption notification is notified by the notification means .

According to the eleventh aspect of the present invention, the notification means notifies the person to be measured of the remaining time until the stop notification is notified.

According to a twelfth aspect of the present invention, the notification means notifies the person to be measured of the remaining time until the specified time is reached while the person to be measured is stopped breathing.

The invention according to claim 13 is adjusted for each of the measured persons in the specified time.

In the invention according to claim 14 , the measuring means measures the oxygen circulation time by using an oxygen saturation indicating an oxygen concentration in blood at a predetermined site of the person to be measured.

In the invention according to claim 15 , the measuring means uses the oxygen saturation indicating the oxygen concentration in blood in the finger of the person to be measured as a predetermined site of the person to be measured, and the oxygen circulation time. To measure.

The invention according to claim 16 includes an input device for receiving an operation of the person to be measured or a measurer who measures biological information of the person to be measured, and a display device for displaying the restart notification.

The invention of the biometric information measuring program according to claim 17 causes a computer to function as each means of the biometric information measuring apparatus according to any one of claims 1 to 16 .

According to the inventions of claims 1 and 17 , oxygen is suppressed in a state in which the variation in the respiratory arrest period in the subject is suppressed as compared with the case where the subject who is in respiratory arrest is not notified of the resumption time of breathing. It has the effect of being able to measure the circulation time.
Further, it has an effect that the person to be measured can be notified of the resumption of respiration according to the detection result of the presence or absence of respiration by the detecting means.

According to the second aspect of the present invention, there is an effect that the measurement of the oxygen cycle time can be started in accordance with the resumption of respiration of the subject.

According to the third aspect of the present invention, there is an effect that the presence or absence of respiration can be detected from the actual respiration state of the person to be measured.

According to the fourth aspect of the present invention, there is an effect that the presence or absence of respiration can be detected without attaching the detecting means to the face of the person to be measured.

According to the fifth aspect of the present invention, there is an effect that the presence or absence of respiration can be detected from the appearance of the person to be measured.

According to the sixth aspect of the present invention, there is an effect that the presence or absence of respiration can be detected without using the detection means for detecting the presence or absence of respiration of the subject.

According to the invention of claim 7 , it has an effect that the measurement of the oxygen cycle time can be started in accordance with the resumption of respiration declared by the subject.

According to the invention of claim 8 , the oxygen circulation time is set as compared with the case where the oxygen circulation time of the subject is measured in a state where the respiratory arrest period exceeds a predetermined time with respect to the specified time. It has the effect of being able to measure correctly.

According to the invention of claim 9 , it has an effect that it is possible to avoid measuring an erroneous oxygen cycle time.

According to the tenth aspect of the present invention, there is an effect that it is possible to instruct the person to be measured to stop and resume breathing in accordance with the measurement of the oxygen cycle time in the biological information measuring device.
Further, it has an effect that the measurement of the oxygen cycle time can be started without confirming the respiratory state of the person to be measured.
Further, it has an effect that the oxygen cycle time can be correctly measured as compared with the case where the measurement of the oxygen cycle time is subsequently started after the notification of the resumption of respiration is notified.

According to the invention of claim 11 , as compared with the case of notifying the breathing stop notice without prior notice, the breathing stop starting point in the subject is measured and the breathing stop period is measured by the biological information measuring device. It has the effect of making it easier to match the starting point to start.

According to the invention of claim 12 , as compared with the case of notifying the resumption of respiration notification without prior notice, the resumption of respiration starting point in the subject is measured by the biometric information measuring device for the period of resumption of respiration. It has the effect that it can be easily adjusted to the end of.

According to the thirteenth aspect of the present invention, the oxygen cycle time of each person to be measured can be correctly measured as compared with the case where the specified time is uniformly set for all the persons to be measured. Has.

According to the invention of claim 14 , it has an effect that the oxygen cycle time can be measured from the oxygen saturation.

According to the invention of claim 15 , it has an effect that the oxygen cycle time can be accurately measured as compared with the case of using the oxygen saturation in blood at a site closer to the heart than the finger. ..

According to the invention of claim 16 , if there is a biological information measuring device, there is an effect that an operation can be accepted and a restart notification can be displayed without separately preparing an input device and a display device.

It is a schematic diagram which shows the measurement example of the oxygen saturation in blood. It is a graph which shows the change example of the absorbance of the light absorbed by a living body. It is a figure which shows an example of the absorbance of light for each wavelength of oxidized hemoglobin and reduced hemoglobin. It is a figure which shows the structural example of the biological information measuring apparatus which concerns on 1st Embodiment. It is a figure which shows the arrangement example of a light emitting element and a light receiving element. It is a figure which shows the other arrangement example of a light emitting element and a light receiving element. It is a figure which shows an example of a respiratory waveform. It is a figure which shows the example of the change of oxygen saturation in blood with the stop and resumption of respiration. It is a figure which shows the example of the composition of the main part of an electric system in a biological information measuring apparatus. It is a flowchart which shows an example of the flow of the biological information measurement processing which concerns on 1st Embodiment and 2nd Embodiment. It is a figure which shows the structural example of the biological information measuring apparatus which concerns on 2nd Embodiment. It is a figure which shows the structural example of the biological information measuring apparatus which concerns on 3rd Embodiment. It is a flowchart which shows an example of the flow of the biological information measurement processing which concerns on 3rd Embodiment. It is a flowchart which shows another example of the flow of the biological information measurement processing which concerns on 3rd Embodiment.

Hereinafter, the present embodiment will be described with reference to the drawings. It should be noted that components and processes having the same function are given the same sign throughout the drawings, and duplicate description is omitted.

<First Embodiment>
The biological information measuring device 10 is a device for measuring biological information relating to the circulatory system, among the information (biological information) relating to the biological body 8. The circulatory system is a general term for a group of organs for transporting a body fluid such as blood while circulating it in the body.

There are multiple indicators of biometric information about the circulatory system, and one of the indicators of the state of the heart that pumps blood into blood vessels is, for example, cardiac output (CO:), which indicates the amount of blood pumped from the heart. Cardiac Output).

Cardiac output varies, for example, it is known that left heart failure is suspected when cardiac output falls below the reference value, and right heart failure is suspected when cardiac output increases below the reference value. It is used for testing heart disease or confirming the effect of medication.

As a method for measuring cardiac output, for example, a catheter with a balloon at the tip is inserted into the pulmonary artery of the subject to be measured for cardiac output, and oxygen in the blood is expanded and contracted while the balloon is inflated and contracted. A method of measuring the degree of saturation and calculating the cardiac output from the measured degree of oxygen saturation is used. Here, the oxygen saturation in blood is an example of an index showing the oxygen concentration in blood, and is an index showing how much hemoglobin in blood is bound to oxygen, and the oxygen saturation in blood is. It indicates that as it decreases, symptoms such as anemia are more likely to occur.

However, the method of measuring cardiac output using a catheter requires surgical treatment because it is necessary to insert a catheter into the blood vessel of the subject, and it is more invasive to the subject than other measurement methods. It gets higher.

Therefore, a method of measuring cardiac output using the oxygen saturation obtained from the pulse wave of the subject is a method so that the burden on the subject is less than that of the method of measuring cardiac output using a catheter. Has been studied. The pulse wave is an index showing a change in the pulsation of a blood vessel accompanying the pumping of blood by the heart.

First, with reference to FIG. 1, a method for measuring oxygen saturation in blood among biological information will be described.

As shown in FIG. 1, the oxygen saturation in blood is applied to the body of the person to be measured (living body 8) by irradiating the body of the person to be measured with light from the light emitting element 1 and receiving the light by the light receiving element 3. It is measured using the intensity of light reflected or transmitted by the circulated arteries 4, veins 5, capillaries 6 and the like, that is, the amount of received light received by the reflected light or transmitted light.

FIG. 2 is a conceptual diagram showing, for example, the amount of change in the amount of light absorbed by the living body 8. As shown in FIG. 2, the absorbance in the living body 8 tends to fluctuate with the passage of time.

Furthermore, looking at the breakdown of the fluctuation of the absorbance in the living body 8, the absorbance mainly fluctuates depending on the artery 4, and the absorbance does not fluctuate in the other tissues including the vein 5 and the quiescent tissue as compared with the artery 4. It is known that the amount of fluctuation is such that it can be regarded as. This is because the arterial blood pumped from the heart moves in the blood vessel with a pulse wave, so that the arterial 4 expands and contracts with time along the cross-sectional direction of the arterial 4, and the thickness of the arterial 4 changes. .. In FIG. 2, the range indicated by the arrow 94 indicates the amount of fluctuation in the amount of absorbance corresponding to the change in the thickness of the artery 4.

In FIG. 2, if the amount of light received at time t _a is I _a and the amount of light received at time t _b is I _b , the amount of change ΔA in the amount of light absorbance due to the change in the thickness of the artery 4 is expressed by Eq. (1). Will be done.

(Number 1)
ΔA = ln (I _b / I _a ) ... (1)

On the other hand, FIG. 3 is a diagram showing an example of the absorption amount of light for each wavelength of hemoglobin (oxidized hemoglobin) bound to oxygen flowing through the artery 4 and hemoglobin not bound to oxygen (reduced hemoglobin). In FIG. 3, graph 96 represents the absorbance of light in oxidized hemoglobin, and graph 97 represents the absorbance of light in reduced hemoglobin.

As shown in FIG. 3, oxidized hemoglobin is more likely to absorb light in the infrared (IR) region 99 having a wavelength near about 850 nm as compared with reduced hemoglobin, and reduced hemoglobin is particularly as compared with oxidized hemoglobin. It is known that light in the red region 98 having a wavelength near about 660 nm is easily absorbed.

Further, it is known that the oxygen saturation is proportional to the ratio of the amount of change ΔA in the amount of absorption at different wavelengths.

Therefore, compared to other combinations of wavelengths, infrared light (IR light) and red light, which are more likely to show a difference in absorption amount between oxidized hemoglobin and reduced hemoglobin, are used to absorb IR light when the living body 8 is irradiated with IR light. The oxygen saturation S is calculated by Eq. (2) by calculating the ratio between the amount of change ΔA _IR and the amount of change ΔA _Red in the amount of absorption when the living body 8 is irradiated with red light. In (2), k is a proportionality constant.

(Number 2)
S = k (ΔA _Red / ΔA _IR ) ・ ・ ・ (2)

That is, when calculating the oxygen saturation in blood, the living body 8 is irradiated with a plurality of light emitting elements 1 that irradiate light having different wavelengths. Specifically, the light emitting element 1 that irradiates IR light and the light emitting element 1 that irradiates red light are used for the living body 8. In this case, the light emitting elements 1 that irradiate the IR light and the light emitting element 1 that irradiates the red light may overlap, but it is desirable that the light emitting periods do not overlap. Then, the light reflected or transmitted light from each light emitting element 1 is received by the light receiving element 3, and the formulas (1) and (2) or these formulas are modified from the amount of light received at each light receiving time. Oxygen saturation is measured by calculating a known formula.

As a known formula obtained by modifying the above formula (1), for example, the formula (1) may be developed and the amount of change ΔA in the amount of light absorption may be expressed as the formula (3).

(Number 3)
ΔA = lnI _b -lnI _a ... (3)

Further, the equation (1) can be modified as the equation (4).

(Number 4)
ΔA = ln (I _b / I _a ) = ln (1 + (I _b -I _a ) / I _a ) ... (4)

Normally, since (I _b -I _a ) << I _a , ln (I _b / I _a ) ≒ (I _b -I _a ) / I _a holds, so instead of equation (1), light Equation (5) may be used as the amount of change in the amount of absorption ΔA.

(Number 5)
ΔA ≒ (I _b -I _a ) / I _a ... (5)

Hereinafter, when it is necessary to distinguish between the light emitting element 1 that irradiates IR light and the light emitting element 1 that irradiates red light, the light emitting element 1 that irradiates IR light is referred to as "light emitting element 1A" and red light. The light emitting element 1 that irradiates the light emitting element 1 is referred to as "light emitting element 1B".

According to such a method, the oxygen saturation in blood is measured by bringing the light emitting element 1 and the light receiving element 3 close to the body surface of the person to be measured. Therefore, a catheter is inserted into a blood vessel to measure the oxygen saturation in blood. The burden on the person to be measured is less than that for measurement.

Then, using the measured oxygen saturation of the subject, the biological information measuring device 10 calculates the cardiac output by the method described later.

FIG. 4 is a diagram showing a configuration example of the biological information measuring device 10. As shown in FIG. 4, the biological information measuring device 10 includes a photoelectric sensor 11, a pulse wave processing unit 12, a respiratory waveform extraction unit 13, an oxygen saturation measuring unit 14, a timer 15, a notification unit 16, and an oxygen circulation time measuring unit 17. And the heart rate output measuring unit 18.

The photoelectric sensor 11 receives a light emitting element 1A that irradiates IR light having a wavelength of about 850 nm as a central wavelength, a light emitting element 1B that irradiates red light having a wavelength of about 660 nm as a central wavelength, and IR light and red light. A light receiving element 3 is provided.

FIG. 5 shows an arrangement example of the light emitting element 1A, the light emitting element 1B, and the light receiving element 3 in the photoelectric sensor 11. As shown in FIG. 5, the light emitting element 1A, the light emitting element 1B, and the light receiving element 3 are arranged side by side toward one surface of the living body 8. In this case, the light receiving element 3 receives the IR light and the red light reflected by the capillaries 6 and the like of the living body 8.

However, the arrangement of the light emitting element 1A, the light emitting element 1B, and the light receiving element 3 is not limited to the arrangement example of FIG. For example, as shown in FIG. 6, the light emitting element 1A, the light emitting element 1B, and the light receiving element 3 may be arranged at positions facing each other with the living body 8 interposed therebetween. In this case, the light receiving element 3 receives the IR light and the red light transmitted through the living body 8.

Here, as an example, the light emitting element 1A and the light emitting element 1B will be described as a surface emitting laser element such as a VCSEL (Vertical Cavity Surface Emitting Laser), but the present invention is not limited to this, and the end surface emitting laser element may be used. Further, the light emitting element 1A and the light emitting element 1B may be LEDs (Light Emitting Diodes).

The photoelectric sensor 11 is provided with a clip (not shown) for attaching the photoelectric sensor 11 to a part of the body of the person to be measured so that IR light and red light do not leak to the outside from the photoelectric sensor 11. Is attached so as to come into contact with the body surface of the subject by a clip (not shown). In order for the light receiving element 3 to receive the IR light and red light reflected or transmitted by the body 8 of the person to be measured as accurately as possible, it is preferable to arrange the photoelectric sensor 11 so as to be in contact with the body surface of the person to be measured. However, the photoelectric sensor 11 is mounted on the body surface within a range in which the IR light and red light reflected by the living body 8 of the subject or the IR light and red light transmitted through the living body 8 of the subject are received by the light receiving element 3. It may be mounted at a position away from.

The photoelectric sensor 11 converts the amount of each of the IR light and the red light received by the light receiving element 3 into, for example, a voltage value and notifies the pulse wave processing unit 12.

Since the light emitting element 1A and the light emitting element 1B are irradiated with a predetermined amount of light, the absorption amount of the IR light and the red light in the living body 8 is calculated from the respective received amounts of the IR light and the red light received by the photoelectric sensor 11. can get.

Therefore, the pulse wave processing unit 12 uses the received light amounts of the IR light and the red light received from the photoelectric sensor 11 to obtain a pulse wave signal representing the pulse wave of the person to be measured obtained from the IR light and infrared rays. Each of them generates a pulse wave signal representing the pulse wave of the subject obtained from the light. The pulse wave processing unit 12 amplifies the voltage value so that the voltage values corresponding to the received amounts of the received IR light and the red light are included in a predetermined range suitable for generating the pulse wave signal. Then, the pulse wave processing unit 12 generates each pulse wave signal from which noise components have been removed by using a known filter or the like.

The pulse wave processing unit 12 notifies the respiratory waveform extraction unit 13 and the oxygen saturation measurement unit 14 of each generated pulse wave signal.

When the respiratory waveform extraction unit 13 receives the pulse wave signal from the pulse wave processing unit 12, it extracts a respiratory waveform representing the respiratory state of the person to be measured from the pulse wave signal.

Specifically, the respiratory waveform extraction unit 13 has a predetermined period (for example, 1 minute) of one of the pulse wave signals obtained from the IR light and the pulse wave signal obtained from the red light. ), The maximum value and the minimum value are detected, and the line connecting each of the detected maximum values (peak line) or the line connecting each detected minimum value (bottom line) is extracted as the respiratory waveform of the subject. ..

FIG. 7 is a diagram showing an example of a respiratory waveform extracted from a pulse wave signal by the respiratory waveform extraction unit 13.

The respiratory waveform extraction unit 13 extracts a respiratory waveform using a pulse wave signal obtained from IR light. This is because, as shown in FIG. 3, IR light is more easily absorbed by oxidized hemoglobin than red light, so that the amplitude of the pulse wave signal with respect to the change in the thickness of the artery 4 is that of the pulse wave signal obtained from the red light. There is a tendency for it to be larger than the amplitude. Therefore, the fluctuation of the waveform of the breathing waveform extracted from the pulse wave signal obtained from the IR light becomes clearer than that of the breathing waveform extracted from the pulse wave signal obtained from the red light, and a highly accurate breathing waveform can be obtained. Because.

The respiratory waveform extraction unit 13 refers to the respiratory waveform extracted from the pulse wave signal, and notifies the notification unit 16 of the respiratory state of the subject such as, for example, the stop of breathing and the resumption of breathing.

The pulse wave signal of the person to be measured is obtained from the amount of light received by the photoelectric sensor 11, and the respiratory state of the person to be measured is detected from the pulse wave signal. Therefore, the biological information measuring device 10 including the photoelectric sensor 11 is included. Can be said to be an example of a detection means for detecting the presence or absence of breathing of the person to be measured.

When the oxygen saturation measuring unit 14 receives the pulse wave signal from the pulse wave processing unit 12, the oxygen saturation measuring unit 14 measures the oxygen saturation of the person to be measured from the received pulse wave signal. Specifically, the oxygen saturation measuring unit 14 uses a pulse wave signal to obtain ΔA _IR , which is the amount of change in the absorbance of IR light due to a change in the thickness of the artery 4, and ΔA _Red , which is the amount of change in the absorbance of red light. Each is calculated according to Eq. (1). Then, the oxygen saturation measuring unit 14 measures the oxygen saturation of the person to be measured from the equation (2), for example, using the calculated change amount ΔA _IR and the change amount ΔA _Red , and the measured oxygen saturation is oxygen-circulated. Notify the time measuring unit 17.

Hereinafter, an example in which the oxygen saturation measuring unit 14 measures the oxygen saturation of the person to be measured will be described as an example, but the oxygen saturation measuring unit 14 is a value indicating a time change of the oxygen saturation of the person to be measured. If there is, any value may be measured. For example, the oxygen saturation measuring unit 14 may measure a value having a correlation with the time change of the oxygen saturation, such as the inverse of the oxygen saturation or the ratio of the change amount ΔA _Red and the change amount ΔA _IR .

The notification unit 16 activates the timer 15 when the breathing waveform extraction unit 13 notifies the person to be stopped breathing, and when the breathing stop period reaches a predetermined predetermined time, the subject during the breathing stop. Notify the measurer of a resumption notice telling them to resume breathing.

The graph of FIG. 8 shows an example of a change in oxygen saturation in blood at a specific site of a subject, the horizontal axis represents time, and the vertical axis represents the reciprocal of oxygen saturation.

When the subject stops breathing at time t ₀ , the oxygen saturation in the blood of the subject begins to decrease. Even if the subject resumes breathing after the lapse of a predetermined time (time t ₁ ), which is the period during which the subject stops breathing, the oxygen taken into the blood by the resumption of breathing is identified from the lungs. Since it takes time to reach the site of, the oxygen saturation in the blood of the subject decreases even after the time _t1 . Oxygen taken into the blood reaches a specific site from the lungs due to the resumption of respiration, so that the oxygen saturation in the blood of the subject starts to increase. The point where the oxygen saturation in the blood changes from decreasing to increasing is called the "inflection point", and if the time when the inflection point appears is time t ₂ , the oxygen circulation time is the difference between time t ₁ and time t ₂ . Represented by.

That is, the oxygen cycle time represents the time required for oxygen to be transported from the lungs to a specific site, and is also called "oxygen transport time".

Since the measurement accuracy of the oxygen circulation time measured from the oxygen saturation tends to vary depending on the variation in the respiratory arrest period, a defined time that defines the respiratory arrest period is provided.

The specified time is determined in advance by an experiment using the actual biometric information measuring device 10 or a computer simulation based on the design specifications of the biometric information measuring device 10 so that the measurement accuracy of the oxygen circulation time in the biometric information measuring device 10 is high. Is the value.

Therefore, the notification unit 16 notifies the person to be informed of the resumption of breathing so that the breathing stop period in the person to be measured approaches the specified time, and the oxygen circulation time measurement unit 17 is also informed that the person to be breathed resumes breathing. Notify that you have done it.

When the oxygen cycle time measuring unit 17 receives the resumption of respiration of the subject from the notification unit 16, the oxygen cycle time measuring unit 17 stores the time at which the resumption of respiration is received as time t ₁ . Then, the oxygen circulation time measuring unit 17 monitors the oxygen saturation measured by the oxygen saturation measuring unit 14 and detects a variation point of the oxygen saturation. The oxygen circulation time measuring unit 17 stores the time when the change point of the oxygen saturation is detected as the time t ₂ , and measures the time represented by the difference between the time t ₁ and the time t ₂ as the oxygen circulation time. The term "detecting an inflection point" includes the case of detecting a position slightly deviated from the inflection point within a range that does not substantially affect the measurement of the oxygen cycle time.

Then, the oxygen cycle time measuring unit 17 notifies the cardiac output measuring unit 18 of the measured oxygen cycle time. As described above, the oxygen cycle time measuring unit 17 is an example of the measuring means for measuring the oxygen cycle time.

The oxygen cycle time measurement site is determined by the mounting position of the photoelectric sensor 11 in the subject, but in the present embodiment, the photoelectric sensor 11 is attached to the peripheral portion of the subject as an example. More specifically, it is attached to the fingertip and the oxygen cycle time when oxygen is transported from the lung to the fingertip is measured. This is because the oxygen circulation time becomes longer because the distance from the lungs can be longer than in other parts, so the oxygen circulation time with higher accuracy is higher than when the photoelectric sensor 11 is attached to other parts. This is because it can be obtained. The "peripheral site" refers to a site located on the peripheral side of the subject's body such as the neck, shoulders, and hip joints.

Therefore, the oxygen cycle time from the lungs to the fingertips is sometimes called LFCT (Lung to Finger Circulation Time). Also in this embodiment, an example in which the photoelectric sensor 11 is attached to the fingertip of the person to be measured and the LFCT is measured by the oxygen cycle time measuring unit 17 will be described, but the attachment portion of the photoelectric sensor 11 is not limited to the fingertip. The photoelectric sensor 11 may be attached to any part of the person to be measured as long as the measurement error of the obtained oxygen cycle time is within a predetermined range. The "fingertip" refers to the fingertip of the person to be measured, but the photoelectric sensor 11 may be attached to the fingertip of the toe.

The cardiac output measuring unit 18 measures the cardiac output of the person to be measured by using the LFCT received from the oxygen cycle time measuring unit 17. The cardiac output is calculated by, for example, a predetermined calculation formula representing the relationship between the LFCT and the cardiac output.

In addition to the cardiac output, the cardiac output measuring unit 18 may measure information regarding the cardiac output. The "information on cardiac output" is information for which a correlation is recognized with the cardiac output, and includes, for example, a cardiac index and a stroke volume.

The "cardiac index" is a value obtained by dividing the cardiac output of the person to be measured by the body surface area of the person to be measured in order to correct the difference in the cardiac output due to the difference in body size of the person to be measured. The "stroke volume" is a value indicating the amount of blood pumped by the heart into the artery 4 by one contraction, and the cardiac output is divided by the heart rate of the subject for one minute. It is required by that.

The biometric information measuring device 10 described above is configured by using, for example, a computer. FIG. 9 is a diagram showing an example of a configuration of a main part of an electric system in a biological information measuring device 10 configured by using a computer 20.

The computer 20 has a CPU (Central Processing Unit) 21, a ROM (Read Only Memory) 22, a RAM (Random Access Memory) 23, and a non-volatile memory 24, which function as a notification means, a measurement means, and a detection means according to the present embodiment. And an input / output interface (I / O) 25. The CPU 21, ROM 22, RAM 23, non-volatile memory 24, and I / O 25 are each connected via the bus 26. There are no restrictions on the operating system used in the computer 20.

The non-volatile memory 24 is an example of a storage device that maintains the stored information even when the power supplied to the non-volatile memory 24 is cut off. For example, a semiconductor memory is used, but a hard disk may be used.

For example, a photoelectric sensor 11, an input unit 27, a display unit 28, and a communication unit 29 are connected to the I / O 25.

The photoelectric sensor 11 is connected to the I / O 25 by wire or wirelessly. The biometric information measuring device 10 and the photoelectric sensor 11 may be configured as separate bodies so as to be separated from each other, and the biometric information measuring device 10 and the photoelectric sensor 11 may be integrated with each other. It may be configured to be housed in the same housing.

The input unit 27 is, for example, an input device that receives an instruction from the user of the biological information measuring device 10 and notifies the CPU 21. The input unit 27 includes, for example, a button, a touch panel, a keyboard, a mouse, and the like. Here, the user of the biological information measuring device 10 includes, for example, an operator such as a person to be measured and an operator such as a medical worker who operates the biological information measuring device 10.

The display unit 28 is, for example, a display device that visually displays the information processed by the CPU 21 to the user of the biological information measuring device 10. For the display unit 28, for example, a display device such as a liquid crystal display, an organic EL (Electro Luminescence), and a projector is used.

The display unit 28 is not necessarily a unit required for the biological information measuring device 10, and may notify the user of the biological information measuring device 10 of information notified from the biological information measuring device 10, such as a notification of resumption of breathing. Any kind of unit may be connected to the I / O 25.

For example, when the information notified from the biological information measuring device 10 is notified to the user of the biological information measuring device 10 by voice, for example, a speaker unit may be connected instead of the display unit 28. Further, when the information notified from the biological information measuring device 10 is notified to the user of the biological information measuring device 10 through the experience, for example, a vibration unit may be connected instead of the display unit 28. Further, the user of the biological information measuring device 10 may be notified of the information notified from the biological information measuring device 10 by using a plurality of units such as the display unit 28 and the speaker unit.

The communication unit 29 includes a communication protocol for connecting a communication line such as the Internet and the biometric information measuring device 10, and performs data communication between the biometric information measuring device 10 and another external device connected to the communication line. The connection form of the communication unit 29 to the communication line may be wired or wireless. Unless it is necessary for the biometric information measuring device 10 to perform data communication with another external device connected to the communication line, it is not always necessary to connect the communication unit 29 to the I / O 25.

The unit connected to the I / O 25 is not limited to the above-mentioned example, and another unit such as a printing unit may be connected to the I / O 25.

Next, the operation of the biological information measuring device 10 will be described with reference to FIG.

FIG. 10 is executed by the CPU 21 when the user of the biometric information measuring device 10 receives an instruction to measure the heart rate output via the input unit 27 with the photoelectric sensor 11 attached to the fingertip of the person to be measured. It is a flowchart which shows an example of the flow of the biological information measurement processing. Upon receiving the cardiac output measurement instruction, the biological information measuring device 10 shall continue to measure the oxygen saturation of the subject until at least the measurement of the cardiac output is completed.

The biometric information measurement program that defines the biometric information measurement process is stored in advance in, for example, the ROM 22 of the biometric information measuring device 10. The CPU 21 of the biometric information measuring device 10 reads the biometric information measuring program stored in the ROM 22 and executes the biometric information measuring process.

First, in step S10, the CPU 21 refers to the respiratory waveform obtained from the pulse wave signal detected by the photoelectric sensor 11 and determines whether or not the subject has stopped breathing due to the measurement of the cardiac output. ..

If it is determined that the person to be measured has not stopped breathing, the process of step S10 is repeatedly executed to monitor the breathing waveform of the person to be measured. On the other hand, if it is determined that the person to be measured has stopped breathing, the process proceeds to step S20.

As an example, the CPU 21 detects the presence or absence of respiration of the subject by the change in the amplitude of the pulse wave, but the method of detecting the presence or absence of respiration of the subject is not limited to this.

For example, an air flow sensor for detecting the flow of air flow or an air volume sensor for detecting the air volume may be attached to the nose and mouth of the person to be measured so as to directly detect the presence or absence of respiration. In addition, when the person to be measured breathes, the air warmed in the body is discharged from the nose and mouth, so by attaching a temperature sensor to the nose and mouth of the person to be measured, the presence or absence of breathing by the person to be measured is directly checked. Detected. Furthermore, since the position of the subject's chest changes with breathing, it is possible to analyze the image of the subject's chest taken with a camera or attach a displacement meter to the subject's chest. The presence or absence of breathing by the measurer is detected.

As described above, the air flow sensor, the air volume sensor, the temperature sensor, the camera, and the displacement sensor used for detecting the presence or absence of breathing in the person to be measured are also examples of the detection means like the photoelectric sensor 11.

In step S20, the CPU 21 activates the timer 15 to start measuring the respiratory arrest period. Here, there is no limitation on the method of measuring the respiratory arrest period, and the CPU 21 may measure the respiratory arrest period using, for example, a timer function built in the CPU 21, or is prepared separately from the biological information measuring device 10. The period of respiratory arrest may be measured using an external timer unit connected to the I / O 25.

In step S30, the CPU 21 refers to the timer value of the timer 15 and determines whether or not the breathing stop period has reached the predetermined time. If the respiratory arrest period has not reached the specified time, the process of step S30 is repeatedly executed to monitor the respiratory arrest period in the subject. On the other hand, when the respiratory arrest period reaches the predetermined time, the process proceeds to step S40.

In this case, in order to restart the breathing of the person to be measured, the CPU 21 notifies the person to be measured to restart the breathing in step S40. Specifically, when the display unit 28 is connected to the biological information measuring device 10, the CPU 21 displays, for example, a message or a figure urging the patient to resume breathing on the display unit 28. Further, when the speaker unit is connected to the biological information measuring device 10, the CPU 21 outputs, for example, a voice prompting to resume breathing from the speaker unit.

In step S50, the CPU 21 refers to the respiration waveform obtained from the pulse wave signal detected by the photoelectric sensor 11 and determines whether or not the person to be measured actually resumes respiration.

If it is determined that the person to be measured has not resumed breathing, the process of step S50 is repeatedly executed to monitor the breathing waveform of the person to be measured. On the other hand, when it is determined that the person to be measured has resumed breathing, the process proceeds to step S60.

When an airflow sensor, an air volume sensor, a temperature sensor, a camera, or a displacement sensor is used to detect the presence or absence of breathing in the person to be measured, the CPU 21 determines the breathing of the person to be measured from changes in these sensor values. It suffices to detect the restart.

In step S40, the subject was notified of the resumption of breathing at the timing when the breathing stop period reached the specified time, but when the notification of resumption of respiration was suddenly notified, the subject was resumed breathing. There may be a delay between receiving the notification and actually resuming breathing. Therefore, in order to inform the person to be measured how long the breathing should be stopped during the breathing stop period, the CPU 21 sequentially displays the remaining time until the specified time is reached on the display unit 28, and is measured. The person may be notified in advance of the end of the respiratory arrest period.

With the resumption of respiration of the subject, in step S60, the CPU 21 acquires the time t _{1 at the time when the resumption of respiration of the subject is detected, and stores the acquired time t 1 in} the RAM 23.

Here, there is no limitation on the method of acquiring the time information, and the CPU 21 may acquire the time information by using, for example, the clock function built in the CPU 21, or is prepared separately from the biometric information measuring device 10. Time information may be acquired from an external clock unit connected to / O25. Further, the CPU 21 may acquire time information from a time server, which is an example of an external device connected to a communication line, via a communication unit 29. Further, the timer 15 may be used.

The time when the resumption of respiration is detected does not mean only one point at the moment when the resumption of respiration is detected, but also a predetermined period after the time when the resumption of respiration is detected and signal processing related to the detection. It means the period including the delay time when etc. are performed.

In step S70, the CPU 21 refers to the oxygen saturation obtained from the pulse wave signal detected by the photoelectric sensor 11, and whether or not the inflection point of the oxygen saturation is detected, in other words, the oxygen saturation decreases. Judge whether or not recovery has started from.

If the oxygen saturation continues to decrease and no inflection is detected, the process of step S70 is repeatedly executed to monitor the change in oxygen saturation. On the other hand, when the inflection point of oxygen saturation is detected, the process proceeds to step S80.

In step S80, the CPU 21 acquires the time t _{2 at the time when the inflection point of the oxygen saturation is detected, and stores the acquired time t 2 in} the RAM 23. The time when the inflection point of oxygen saturation is detected does not mean only one point at the moment when the inflection point of oxygen saturation is detected, but is after the time when the inflection point of oxygen saturation is detected. It refers to a predetermined period and a period including a delay time in which signal processing related to detection is performed.

The CPU 21 acquires the difference between the time t ₂ and the time t ₁ stored in the RAM 23 in step S60 as an LFCT.

In step S90, the CPU 21 measures the cardiac output from, for example, Eq. (6) using the LFCT acquired in step S80. Further, the CPU 21 may calculate information regarding the cardiac output using the measured cardiac output.

As a result, the biological information measurement process shown in FIG. 10 is completed.

The period of respiratory arrest for which LFCT is accurately measured varies depending on, for example, the age, gender, and physical condition of the subject. Therefore, based on the information of the person to be measured set by the user of the biometric information measuring device 10 in the biometric information measuring device 10 via the input unit 27, the CPU 21 sets a predetermined time for defining the respiratory arrest period for each person to be measured. May be adjusted to. Further, the user of the biological information measuring device 10 may adjust the specified time.

The specified time may be set in units of 1 second, for example, or a time selected from a plurality of prepared times such as 15 seconds, 20 seconds, and 25 seconds may be set as the specified time. The setting unit of the specified time is not limited, and may be, for example, in milliseconds or 5 seconds.

The set specified time for each person to be measured is stored in, for example, the non-volatile memory 24, and the information that identifies the person to be measured, such as the name of the person to be measured or the patient number, is measured as biometric information prior to the measurement instruction of the heart rate output. When input to the device 10, the CPU 21 uses the specified time associated with the person to be measured for the determination in step S30 of FIG.

As shown in step S50 of FIG. 10, the CPU 21 waits for the subject to actually resume breathing before starting the LFCT measurement, but the biometric information measuring device 10 breathes into the subject. If the period from the notification of the resumption of breathing to the resumption of breathing of the subject is delayed, the period of breathing arrest becomes longer than the specified time, and compared with the case where the period of respiratory arrest is adjusted to the specified time. Therefore, the measurement accuracy of LFCT may be low.

Therefore, the CPU 21 may measure the LFCT when the period from the notification of the resumption of respiration to the resumption of respiration of the subject is within the allowable delay period, which is a predetermined period. .. In other words, if the period from the notification of the resumption of respiration to the resumption of respiration of the subject exceeds the permissible delay period, the CPU 21 cancels the execution of the processing after step S60 in FIG. Therefore, the biometric information measurement process shown in FIG. 10 may be terminated without measuring the LFCT.

As described above, according to the biological information measuring device 10 according to the first embodiment, the respiratory state of the person to be measured and the oxygen saturation in blood are measured by using the pulse wave obtained from the sensor value of the photoelectric sensor 11, and the subject is subject to measurement. The heart rate output is measured from the breathing state of the measurer and the oxygen saturation in the blood.

In addition, the biological information measuring device 10 notifies the subject to be notified of the resumption of respiration at a predetermined time.

<Second Embodiment>
The biological information measuring device 10 according to the first embodiment measures the breathing state of the person to be measured by using the photoelectric sensor 11, starts measuring the breathing stop period when the breathing stop is detected, and resumes breathing. When was detected, the measurement of oxygen circulation time was started.

However, the respiratory state of the person to be measured may be obtained without using a detection means for detecting the presence or absence of respiration such as the photoelectric sensor 11.

In the second embodiment, biological information that measures the respiratory state of the person to be measured without using a detection means for detecting the presence or absence of respiration, such as the photoelectric sensor 11, and notifies the resumption of respiration at the end of the specified time. The measuring device 10A will be described.

FIG. 11 is a diagram showing a configuration example of the biological information measuring device 10A. The configuration example of the biological information measuring device 10A shown in FIG. 11 differs from the configuration example of the biological information measuring device 10 shown in FIG. 4 in that the respiratory waveform extraction unit 13 is deleted and the reception unit 19 is added instead. Is. Further, with the above change, the notification unit 16 has been replaced with the notification unit 16A.

The input unit 27 includes an input member operated by the person to be measured to notify the biological information measuring device 10A of the stop of respiration and the resumption of respiration. Here, as an example, the subject will be described as notifying the biological information measuring device 10A of the stop of respiration and the resumption of respiration by pressing a button.

The input unit 27 notifies the reception unit 19 of the operation status of the button by the person to be measured.

The reception unit 19 is an example of a reception means that receives the respiratory state of the person to be measured depending on the operation status of the button notified from the input unit 27. Specifically, when the button associated with the stop of breathing is pressed, the reception unit 19 considers that the person to be measured has stopped breathing. Further, when the button associated with the resumption of respiration is pressed, the reception unit 19 considers that the respiration of the subject has been resumed.

Then, the reception unit 19 notifies the notification unit 16A of the respiratory state of the person to be measured, for example, stopping breathing and resuming breathing.

The notification unit 16A activates the timer 15 when the reception unit 19 notifies the person to be stopped breathing, and when the breathing stop period reaches the specified time, the person to be measured who is in the respiratory state is in breathing. Notify the resumption notification. Further, when the reception unit 19 notifies the measurement unit that the measurement unit has resumed breathing, the notification unit 16A also notifies the oxygen cycle time measurement unit 17 that the measurement person's breathing has resumed.

The biometric information measuring device 10A described above is configured by using, for example, a computer, like the biometric information measuring device 10 according to the first embodiment. In this case, the configuration example of the main part of the electrical system in the biological information measuring device 10A is the same as the configuration example of the main part of the electrical system in the biological information measuring device 10 shown in FIG.

Further, the flowchart showing an example of the flow of the biological information measurement process in the biological information measuring device 10A is the same as the flowchart showing an example of the flow of the biological information measuring process in the biological information measuring device 10 shown in FIG.

However, in step S10 of FIG. 10, the biological information measuring device 10 refers to the breathing waveform obtained from the pulse wave signal detected by the photoelectric sensor 11, and determines whether or not the subject has stopped breathing. On the other hand, the biological information measuring device 10A determines whether or not the person to be measured has stopped breathing by referring to the pressed state of the button associated with the stop of breathing. Further, in step S50 of FIG. 10, the biological information measuring device 10 referred to the breathing waveform obtained from the pulse wave signal detected by the photoelectric sensor 11, and determined whether or not the subject resumed breathing. On the other hand, the biological information measuring device 10A determines whether or not the person to be measured has resumed breathing by referring to the pressed state of the button associated with the resumption of breathing.

The button for notifying the biological information measuring device 10A of the respiratory state of the person to be measured is operated by a person who measures the biological information such as a medical worker who confirmed the respiratory state of the person to be measured on behalf of the person to be measured. May be good.

The contents of various modifications relating to the biological information measurement process described in the first embodiment are also applied to the biological information measuring device 10A.

As described above, according to the biological information measuring device 10A according to the second embodiment, the measured person breathes according to the specified time based on the report of the measured person's respiratory state by the measured person or the person who measures the biological information. Notify the resumption notice and measure the heart rate output of the subject.

<Third Embodiment>
In the biological information measuring device 10 according to the first embodiment and the biological information measuring device 10A according to the second embodiment, the measurement of the respiratory arrest period and the measurement of the LFCT were started according to the respiratory state of the subject.

In the third embodiment, the subject adjusts the respiratory condition to the instruction notified by the biological information measuring device, so that the measurement of the respiratory arrest period and the measurement of the LFCT are started without confirming the respiratory condition of the subject. , The biological information measuring device 10B for measuring the heart rate output of a person to be measured will be described.

FIG. 12 is a diagram showing a configuration example of the biological information measuring device 10B. The configuration example of the biological information measuring device 10B shown in FIG. 12 differs from the configuration example of the biological information measuring device 10 shown in FIG. 4 in that the respiratory waveform extraction unit 13 is deleted and the notification unit 16 is replaced with the notification unit 16B. It is a point.

When the notification unit 16B receives the measurement instruction of the heart rate output, it notifies the breathing stop notification according to a predetermined rule and activates the timer 15, and when the timer value of the timer 15 reaches the specified time, the notification unit 16B breathes. Not only the person to be measured is notified of the resumption of breathing, but also the oxygen circulation time measuring unit 17 is notified that the person to be measured has resumed breathing.

Here, the "predetermined rule" is the notification timing of the breathing stop notification, for example, the notification of the breathing stop is notified after n seconds (n is an integer of 0 or more) after receiving the measurement instruction of the cardiac output. It is a set rule. The value of n seconds that determines the notification timing of the breathing stop notification is called "waiting time" and is a value changed by the user of the biological information measuring device 10B.

The oxygen circulation time measuring unit 17 starts measuring the LFCT when the notification unit 16B receives that the subject's breathing has resumed, and the cardiac output measuring unit 18 measures the measured person's cardiac output. can get.

The biometric information measuring device 10B described above is configured by using, for example, a computer, like the biometric information measuring device 10 according to the first embodiment. In this case, the configuration example of the main part of the electrical system in the biological information measuring device 10B is the same as the configuration example of the main part of the electrical system in the biological information measuring device 10 shown in FIG.

Next, the operation of the biological information measuring device 10B will be described with reference to FIG.

FIG. 13 is a flowchart showing an example of the flow of the biometric information measurement process executed by the CPU 21 when the biometric information measuring device 10B is activated.

A photoelectric sensor 11 is attached to the fingertip of the person to be measured, and when the biological information measuring device 10B receives a measurement instruction of the heart rate output, the oxygen saturation of the person to be measured is measured at least until the measurement of the heart rate output is completed. It shall continue to measure. Further, it is assumed that the standby time in the biological information measuring device 10B is set to n seconds in advance.

The biometric information measurement program that defines the biometric information measurement process is stored in advance in, for example, the ROM 22 of the biometric information measuring device 10B. The CPU 21 of the biometric information measuring device 10B reads the biometric information measuring program stored in the ROM 22 and executes the biometric information measuring process.

The difference between the flowchart of the biological information measurement process shown in FIG. 13 and the flowchart of the biological information measurement process according to the first embodiment and the second embodiment shown in FIG. 10 is the step of detecting the respiratory arrest of the person to be measured. S10 and step S50 for detecting the resumption of breathing of the subject have been deleted, and steps S2 to S8, S15, and S25 have been added.

First, in step S2, the CPU 21 determines whether or not the measurement instruction of the cardiac output is received from the user of the biological information measuring device 10B via the input unit 27.

If it is determined that the cardiac output measurement instruction is not accepted, the process of step S2 is repeatedly executed to monitor the instruction from the user. On the other hand, if it is determined that the cardiac output measurement instruction has been accepted, the process proceeds to step S4.

In step S4, the CPU 21 activates the timer 15 to start measuring the standby time.

In step S6, the CPU 21 determines whether or not the timer value of the timer 15 has reached the standby time.

If the timer value of the timer 15 has not reached the standby time, the process proceeds to step S8, and in step S8, the CPU 21 notifies the person to be measured of the remaining time until the standby time ends. There is no limitation on the method of notifying the person to be measured of the remaining time until the waiting time ends. For example, when the display unit 28 is connected to the biological information measuring device 10B, the remaining time until the waiting time ends. Is displayed on the display unit 28. When the speaker unit is connected to the biological information measuring device 10B, the person to be measured is notified by voice of the remaining time until the standby time ends. When the vibration unit is connected to the biological information measuring device 10B, the vibration unit is vibrated, and the remaining time until the end of the standby time is notified to the person to be measured through the experience of the person to be measured.

Then, the process proceeds to step S6, and the process of determining whether or not the timer value of the timer 15 has reached the standby time is repeated.

On the other hand, if it is determined in the determination process of step S6 that the timer value of the timer 15 has reached the standby time, the process proceeds to step S15.

Since the waiting time has elapsed since the time after receiving the cardiac output measurement instruction, the CPU 21 stops the timer 15 and notifies the person to be measured of the breathing stop notification in step S15. As a result, the CPU 21 assumes that the subject has stopped breathing, executes step S20 already described, activates the timer 15 again, and starts measuring the breathing stop period. That is, the biological information measuring device 10B starts measuring the respiratory arrest period without confirming the respiratory arrest in the subject.

Then, until it is determined in step S30 that the breathing stop period has reached the specified time, the CPU 21 measures the remaining time until the specified time ends by using the notification method described in step S8 in step S25. Notify the person.

Further, unlike the biological information measuring devices 10 and 10A, the CPU 21 executes step S60 without confirming the resumption of respiration of the subject after notifying the resumption of respiration, and continuously starts the measurement of LFCT. do.

After that, steps S70 to S90 already described are executed, and the cardiac output of the person to be measured is measured. As a result, the biological information measurement process shown in FIG. 13 is completed.

In steps S8 and S25, the remaining time until the end of the waiting time and the remaining time until the end of the specified time are notified, respectively, but there is no limitation on the method of expressing the remaining time. For example, when notifying from 10 seconds before the remaining time, the remaining time is notified to the person to be measured in a countdown format such as "10"-> "9"->, ...,-> "1"-> "0". May be good. Also, for example, when notifying the person to be notified from 10 seconds before the remaining time, the remaining time is counted up to the person to be measured, such as "0" → "1" →, ..., → "9" → "10". You may notify.

The contents of various modifications relating to the biological information measurement process described in the first embodiment are also applied to the biological information measuring device 10B. However, the biological information measuring device 10B starts the measurement of LFCT without confirming the resumption of respiration of the subject after notifying the resumption of respiration. Therefore, it is determined whether or not the period from the notification of the resumption of breathing to the actual resumption of breathing of the subject is within the permissible delay period, and if the period exceeds the permissible delay period, the LFCT The modification of terminating the biometric information measurement process shown in FIG. 13 without measuring is not applied.

However, even if the person to be measured is notified of the resumption of respiration from the biological information measuring device 10B, the person to be measured will resume respiration after recognizing that the notification of resumption of respiration has been notified. It is conceivable that a delay time will occur from the time when the device 10B notifies the resumption notification until the respiration is actually resumed.

Therefore, in the biological information measuring device 10B, the LFCT may be measured in consideration of this delay time.

FIG. 14 is a flowchart showing an example of the flow of the biological information measurement process in consideration of the delay time associated with the resumption of respiration.

The flowchart shown in FIG. 14 differs from the flowchart of the biological information measurement process shown in FIG. 13 in that steps S45 and S55 are added between steps S40 and S60.

After notifying the resumption of respiration notification in step S40, the CPU 21 activates the timer 15 in step S45.

In step S55, the CPU 21 determines whether or not the timer value of the timer 15 started in step S40 has reached a predetermined delay time. The delay time represents the standard time from the notification of the resumption of respiration to the actual resumption of respiration of the subject, and is based on an experiment using an actual biometric information measuring device 10B for a plurality of subjects. It is a value obtained in advance.

In the determination process of step S55, if the timer value of the timer 15 has not reached the delay time, the process of step S55 is repeatedly executed to monitor the timer value of the timer 15. On the other hand, when the timer value of the timer 15 reaches the delay time, the process proceeds to step S60 and the measurement of LFCT is started. That is, the biometric information measuring device 10B that executes the biometric information measuring process shown in FIG. 14 has a delay time shorter than the time from the notification of the resumption of respiration notification to the detection of the variation point of the saturated oxygen degree. Measured as LFCT.

Here, as an example, the delay in resumption of breathing has been described, but the same can be said for respiratory arrest. Therefore, the processing of steps S45 and S55 in FIG. 14 may be added between steps S15 and S20. The delay time in this case represents the standard time from the notification of the stop breathing notification to the actual stop of the breathing of the subject, and the actual machine of the biological information measuring device 10B for a plurality of subjects was used. It is a value obtained in advance by an experiment.

As described above, according to the biological information measuring device 10B according to the third embodiment, the measurement of the respiratory arrest period and the measurement of the LFCT are started without confirming the respiratory state of the measured person, and the heartbeat output of the measured person is started. Measure the amount.

Although the present invention has been described above using each embodiment, the present invention is not limited to the scope described in each embodiment. Various changes or improvements can be made to each embodiment without departing from the gist of the present invention, and the modified or improved forms are also included in the technical scope of the present invention. For example, the order of processing may be changed without departing from the gist of the present invention.

Further, in each embodiment, a mode in which the biometric information measurement processing is realized by software has been described as an example, but the same processing as the flowcharts shown in FIGS. 10, 13, and 14 can be performed by, for example, ASIC (Application Specific). It may be mounted on an integrated circuit) and processed by hardware. In this case, the speed of the detection process can be increased.

Further, in each of the above-described embodiments, the embodiment in which the biometric information measurement program is installed in the ROM 12 has been described, but the present invention is not limited thereto. The biological information measurement program according to the present invention can also be provided in a form recorded on a computer-readable storage medium. For example, the biometric information measurement program according to the present invention may be provided in the form of being recorded on an optical disk such as a CD (Compact Disc) -ROM or a DVD (Digital Versatile Disc) -ROM. Further, the biometric information measurement program according to the present invention may be provided in the form of being recorded in a semiconductor memory such as a USB memory and a flash memory. Further, the biometric information measuring devices 10, 10A and 10B may acquire the biometric information measuring program according to the present invention from an external device connected to the communication line via the communication unit 29.

1 (1A, 1B) ... light emitting element 3 ... light receiving element 4 ... artery 5 ... vein 6 ... capillary 8 ... living body 10 (10A, 10B) ... biological information measurement Device 11 ... Photoelectric sensor 12 ... Pulse wave processing unit 13 ... Respiratory waveform extraction unit 14 ... Oxygen saturation measurement unit 15 ... Timer 16 (16A, 16B) ... Notification unit 17.・ ・ Oxygen circulation time measurement unit 18 ・ ・ ・ Heart rate output measurement unit 19 ・ ・ ・ Reception unit 20 ・ ・ ・ Computer 21 ・ ・ ・ CPU
22 ... ROM
23 ... RAM
24 ... Non-volatile memory 27 ... Input unit 28 ... Display unit 29 ... Communication unit 98 ... Red area 99 ... Infrared area

Claims (17)

When the specified time for the period of respiratory arrest is reached, a notification means for notifying the subject who is in respiratory arrest to resume breathing, and a notification means.
A measuring means for measuring the oxygen cycle time, which represents the time required for oxygen taken into the body of the person to be measured to reach a predetermined site by resuming breathing of the person to be measured.
A detection means for detecting the presence or absence of breathing of the person to be measured is provided.
The notification means notifies the resumption notification when the elapsed time from the detection of the stop of breathing of the person to be measured by the detection means reaches the specified time.
Biological information measuring device. The biometric information measuring device according to claim 1 , wherein the measuring means measures the oxygen cycle time when the detection means detects the respiration of the person to be measured after the notification of the resumption notification by the notification means. The biometric information measuring device according to claim 1 or 2 , wherein the detecting means detects the presence or absence of respiration of the person to be measured by the flow of air in the nose and mouth of the person to be measured. The biometric information measuring device according to claim 1 or 2 , wherein the detecting means detects the presence or absence of respiration of the person to be measured by a change in the amplitude of a pulse wave in the person to be measured. The biological information measuring device according to claim 1 or 2 , wherein the detecting means detects the presence or absence of breathing of the person to be measured by the movement of the chest of the person to be measured. When the specified time for the period of respiratory arrest is reached, a notification means for notifying the subject who is in respiratory arrest to resume breathing, and a notification means.
A measuring means for measuring the oxygen cycle time, which represents the time required for oxygen taken into the body of the person to be measured to reach a predetermined site by resuming breathing of the person to be measured.
The information is notified by the operation of the person to be measured or the person who measures the biological information of the person to be measured , and is provided with a receiving means for receiving the information indicating that the person to be measured has stopped breathing.
The notification means notifies the resumption notification when the elapsed time from receiving the information indicating that the person to be measured has stopped breathing by the reception means reaches the specified time.
Biological information measuring device. The biological information measuring device according to claim 6 , wherein the measuring means measures the oxygen cycle time when the receiving means receives information indicating that the person to be measured has started breathing after the notification of the resumption notice. The measuring means measures the oxygen cycle time when the period from the notification of the resumption notification by the notification means to the resumption of respiration by the subject is within a predetermined period. The biometric information measuring device according to any one of claim 7 . The measuring means is claimed to stop the measurement of the oxygen cycle time when the period from the notification of the resumption notification by the notification means to the resumption of respiration by the subject exceeds a predetermined period. The biometric information measuring device according to any one of claims 1 to 7 . When the specified time for the period of respiratory arrest is reached, a notification means for notifying the subject who is in respiratory arrest to resume breathing, and a notification means.
A measuring means for measuring the oxygen cycle time, which represents the time until the oxygen taken into the body of the person to be measured reaches a predetermined site by the resumption of breathing of the person to be measured, is provided.
The notification means notifies the person to be measured of the stop of breathing so that the person to be measured stops breathing, and when the elapsed time from the notification of the stop notification reaches the specified time, the said means. Notify the resumption notification,
The measuring means measures the oxygen cycle time after a predetermined time has elapsed after the notification means has notified the restart notification .
Biological information measuring device. The biological information measuring device according to claim 10 , wherein the notification means notifies the person to be measured of the remaining time until the stop notification is notified. The biometric information measurement according to any one of claims 1 to 11 , wherein the notification means notifies the person to be measured of the remaining time until the specified time is reached while the person to be measured has stopped breathing. Device. The biometric information measuring device according to any one of claims 1 to 12 , wherein the specified time is adjusted for each of the measured persons. The measuring means according to any one of claims 1 to 13 , wherein the measuring means measures the oxygen circulation time by using an oxygen saturation indicating the oxygen concentration in blood at a predetermined site of the person to be measured. The biometric information measuring device described. The 14th aspect of claim 14 , wherein the measuring means measures the oxygen circulation time by using an oxygen saturation indicating the oxygen concentration in blood in the finger of the person to be measured as a predetermined part of the person to be measured. Biometric information measuring device. An input device that accepts the operation of the person to be measured or the person who measures the biological information of the person to be measured.
The biometric information measuring device according to any one of claims 1 to 15 , further comprising a display device for displaying the restart notification. A biometric information measurement program for allowing a computer to function as each means of the biometric information measuring apparatus according to any one of claims 1 to 16 .

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