JP7067824B1 - Biological information measuring device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a biological information measuring device capable of dealing with a person to be measured having various arm thicknesses and improving the detection accuracy of an electrocardiographic waveform. The biological information measuring device of the present invention is a biological information measuring device having at least a main body portion, and the main body portion has a first arm portion that curves from the upper part of the main body portion to the lower portion of the main body portion and extends to the left and right. The ends of the first arm and the second arm, including the second arm, are separated from each other, and biometric information is stored on at least one end side of the first arm and the second arm. It is equipped with an electrode to measure. Further, at least one of the first arm portion and the second arm portion extends outward in the front-rear direction at the lower part of the main body portion. Further, at least a part of both ends of the first arm portion and the second arm portion extends to a length that overlaps with each other in the front-rear direction at the lower portion of the main body portion. Further, at least one of the ends of the first arm portion and the second arm portion is further curved from the lower portion side of the main body portion to the upper portion side of the main body portion. [Selection diagram] Fig. 1

Description

The present disclosure relates to a biological information measuring device for measuring biological information of a subject.

It is effective for health management to continuously measure blood pressure and detect the disease at an early stage or detect the change in the condition from the change. Therefore, a biological information measuring device for continuously measuring biological information such as blood pressure without pressurizing the arm or the like with a cuff or the like has been proposed.

For example, Patent Document 1 includes an optical sensor module and a motion sensor, and wears a wrist capable of measuring biological information such as heartbeat, stress, and blood oxygen saturation of a person to be measured based on the reflected light detected by the optical sensor module. In the type wearable, a wearing configuration to be worn on the wrist by a belt type strap is illustrated.

Japanese Unexamined Patent Publication No. 2019-042500

However, in a configuration such as a conventional wristwatch as exemplified in Patent Document 1, which is worn on the wrist with a belt, it is difficult to wear the wristwatch when the hand is paralyzed, and the information measuring device can be easily worn. Is required.

On the other hand, as an idea for facilitating wearing, it is conceivable to use a bracelet type information measuring device (Patent Document 1 also describes only the word "bracelet type"). In the case of such a bracelet type, it is necessary to make a gap between the mounting location and the measuring device in order to make it easier to pass the wrist through the bracelet part, so measurement information is acquired in close contact with the wrist like an optical sensor module. The configuration and the desired configuration are in conflict with each other, and a more complicated mechanism is required to achieve both of them.

Therefore, an object of the present invention is to provide a biometric information measuring device capable of dealing with a person to be measured having various arm thicknesses and improving the detection accuracy of an electrocardiographic waveform.

In order to solve the above problems, the biometric information measuring device of the present invention is a biometric information measuring device having at least a main body, and the main body is curved from the upper part of the main body to the lower part of the main body to the left and right. The first arm and the end of the second arm include the extending first arm and the second arm, and the ends of the first arm and the second arm are separated from each other, and at least one of the first arm and the second arm. An electrode for measuring biometric information is provided on the end side of the arm.

According to the above-mentioned biometric information measuring device, it is possible to provide a biometric information measuring device capable of dealing with a person to be measured having various arm thicknesses and improving the detection accuracy of an electrocardiographic waveform.

It is a figure for demonstrating the left arm of the person to be measured, the biological information measuring apparatus, the electrode of the measuring part, and the like which concerns on this Embodiment. It is a perspective view of the biological information measuring apparatus which concerns on this embodiment. It is a hexagonal view of the biological information measuring apparatus which concerns on this embodiment. It is a figure for showing the configuration example which connects the thermistor to the electrode of the biological information measuring apparatus which concerns on this embodiment. It is a schematic block diagram which shows the structure of the biological information measurement system which concerns on this embodiment. It is a figure for demonstrating the example of the electrocardiographic waveform and the pulse wave which concerns on this embodiment. It is a flowchart for demonstrating operation of the blood pressure information measurement system which concerns on this Embodiment.

The contents of the embodiments of the present invention will be described in a list. The biological information measuring device according to the embodiment of the present invention has the following configuration.
[Item 1]
A biological information measuring device having at least a main body,
The main body portion includes a first arm portion and a second arm portion that are curved from the upper portion of the main body portion to the lower portion of the main body portion and extend to the left and right, respectively.
The first arm portion and the end portion of the second arm portion are separated from each other.
An electrode for measuring biometric information is provided on at least one end side of the first arm portion and the second arm portion.
A biological information measuring device characterized by this.
[Item 2]
At least one of the first arm portion and the second arm portion extends outward in the front-rear direction at the lower portion of the main body portion.
The biometric information measuring device according to claim 1.
[Item 3]
At least a part of both ends of the first arm portion and the second arm portion extends to a length that overlaps with each other in the front-rear direction at the lower portion of the main body portion.
The biological information measuring apparatus according to claim 2.
[Item 4]
At least one of the first arm portion and the end portion of the second arm portion is further curved from the lower portion side of the main body portion toward the upper portion side of the main body portion.
The biometric information measuring device according to any one of claims 1 to 3.
[Item 5]
The material of the first arm portion and the second arm portion includes a thermoplastic elastomer.
The biometric information measuring device according to any one of claims 1 to 4.
[Item 6]
The thermoplastic elastomer comprises at least a polyether block amide.
The biological information measuring apparatus according to claim 5.
[Item 7]
The main body does not have a display.
The biometric information measuring device according to any one of claims 1 to 6, wherein the biological information measuring device is characterized.
[Item 8]
Two electrodes are provided on the same end side of the end side of the first arm portion and the second arm portion.
The biometric information measuring device according to any one of claims 1 to 6, wherein the biological information measuring device is characterized.
[Item 9]
One electrode is provided on each of the different end sides of the first arm portion and the end portion side of the second arm portion.
The biometric information measuring device according to any one of claims 1 to 6, wherein the biological information measuring device is characterized.
[Item 10]
Two electrodes are provided on different end sides of the first arm portion and the end portion side of the second arm portion.
The biometric information measuring device according to any one of claims 1 to 6, wherein the biological information measuring device is characterized.
[Item 11]
It comprises an amplifier that amplifies the potential difference between the two electrodes provided on the same end side.
The biometric information measuring device according to any one of claims 1 to 10.
[Item 12]
The main body portion has a reference voltage terminal for acquiring a reference voltage on the upper portion of the main body portion, and inputs the reference voltage to the amplifier.
The biological information measuring apparatus according to claim 11.
[Item 13]
The reference voltage terminal is connected to a thermistor that measures the skin temperature of the subject.
The biological information measuring apparatus according to claim 12.
[Item 14]
The main body includes an optical sensor module for measuring a pulse wave of a person to be measured.
The biometric information measuring device according to any one of claims 1 to 13.
[Item 15]
The main body unit includes a communication unit that outputs the measured biological information to the outside.
The biometric information measuring device according to any one of claims 1 to 14, wherein the biometric information measuring device is characterized.

Hereinafter, this embodiment will be described. The embodiments described below do not unreasonably limit the content of the present invention described in the claims. Moreover, not all of the configurations described in the present embodiment are essential constituent requirements of the present invention. In addition, the features shown in each embodiment can be applied to other embodiments as long as they do not contradict each other.

<Structure>
The biological information measuring device 100 and the arm as the measurement site of the person to be measured will be described with reference to FIGS. 1-3. FIG. 1A shows a state in which the biological information measuring device 100 is attached to the left arm of the person to be measured. FIG. 1B is a perspective view of the radial artery and the ulnar artery of the left arm of the subject, and is a diagram showing the positional relationship between the radial artery, the ulnar artery, and the electrode of the biometric information measuring device 100. FIG. 1C is a diagram showing the positional relationship between the arm of the person to be measured, the electrode of the biological information measuring device 100, and the optical sensor. FIG. 2 is a perspective view of the biological information measuring device 100. FIG. 3 is a six-view view of the biological information measuring device 100. In FIG. 2, the direction in which the arm of the biological information measuring device 100 is inserted is the front-back direction, the upper surface portion 102 side direction and the direction opposite to the arm are the vertical direction, and the first arm portion 131 and the second arm portion 131 and the second from the upper part of the main body portion 101. The direction in which the arm portion 132 extends is defined as the left-right direction for convenience.

As shown in FIG. 1-3, the biological information measuring device 100 includes a main body portion 101 and an upper surface portion 102. The main body 101 includes a first arm 131 and a second arm 132 that are curved from the upper part of the main body 101 on the back side of the hand along the wrist of the person to be measured and extend to the lower part of the main body 101, respectively. The ends of the first arm 131 and the second arm 132 are separated from each other and have a non-annular shape as a component (that is, the first arm 131 and the second arm separated from each other). It does not prevent the surfaces of both ends of the portion 132 from coming into contact with each other to form a shape that can be called an annular shape). Then, at least one of the ends of the first arm portion 131 and the second arm portion 132 (both ends in FIGS. 2 and 3) may extend outward in the front-rear direction at the lower portion of the main body portion 101. In particular, as shown in the lower view of FIG. 3, at least a part of both end portions of the first arm portion 131 and the second arm portion 132 may extend to a length so as to overlap each other in the front-rear direction. Further, at least one of the ends of the first arm 131 and the second arm 132 (the end of the first arm 131 in FIGS. 2 and 3) is inward on the side of the inserted arm (main body 101). It may be curved (from the lower side to the upper side of the main body 101). The material (particularly, the material of the first arm portion 131 and the second arm portion 132) constituting the biometric information measuring device 100 is not particularly limited, but has elasticity and excellent workability. It is preferably a thermoplastic elastomer, and particularly preferably a polyether block amide (PEBA). Then, for example, at least a part of at least one of the main body portion 101, the upper surface portion 102, the first arm portion 131, and the second arm portion 132 may be created by a molding process using the above-mentioned material, and as such. The biometric information measuring device 100 may be configured by connecting the created members to each other.

With such a configuration, when the arm of the person to be measured is inserted between the first arm 131 and the second arm 132 of the main body 101, the first arm 131 and the second arm 132 are at least in the left-right direction. By elastically deforming and spreading, it is possible to accommodate various arm sizes in one size, and it is also possible to configure it so that fasteners (fixing tools) such as belts and surface fasteners are not required. Therefore, for example, even if the hand is paralyzed, it can be easily attached. Further, when the ends of the first arm portion 131 and the second arm portion 132 extend outward in the front-rear direction and extend to a length such that they overlap each other in the front-rear direction, so that they are annular like a bangle. Since it is possible to take a sufficient length as compared with the above, even when a thick arm is inserted into the biological information measuring device 100, for example, it is provided on the end side of the first arm portion 131 and the second arm portion 132. Each electrode (described later) can be placed near the artery without being too far from the artery. Further, since the ends of the first arm portion 131 and the second arm portion 132 are curved inward (from the lower side of the main body portion 101 to the upper side of the main body portion 101) which is the arm side through which the first arm portion 131 is inserted, the first arm portion Even when the 131 and the second arm 132 are elastically deformed and spread in at least the left-right direction, the structure is such that they are easily caught by the arm of the person to be measured, and the first arm 131 and the second arm 132 have a structure. Each electrode provided on the end side can be sufficiently brought into contact with the surface of the arm.

The upper surface portion 102 is provided on the outside of the upper portion of the main body portion 101, and may serve as a lid portion when a circuit board, a battery, or the like is stored in the main body portion 101. Further, the upper surface portion 102 may have a display unit function, for example, a time display function or a biological information display function. However, when the upper surface portion 102 is provided with the display unit function, the number of required components increases and the main body portion 101 becomes large. Therefore, it is more preferable that the upper surface portion 102 does not have the display unit function when miniaturization is required. In that case, when the person to be measured wants to confirm his / her own biometric information, the biometric information measuring device 100 communicates with an external terminal device 200 (see FIG. 5), and the terminal device display unit 214 of the terminal device 200 communicates with the measured person. It may be possible to display biological information.

The main body 101 has a first electrode 121 and a second electrode 122 on the end side of the second arm 132, and has a third electrode 123 and a fourth electrode 124 on the end side of the first arm 131. The upper inner portion of the main body 101 includes a fifth electrode 125, a sixth electrode 126, an optical sensor module 111, and the like. The sixth electrode 126 may be provided, for example, as a terminal for charging a battery, may be provided as a terminal for communication with an external device, or may have both uses. , May be provided for purposes other than these.

As shown in FIG. 1 (B), the radial artery 911 and the ulnar artery 912 pass through the arm of the subject. The radial artery 911 runs between the radius and the skin on the surface of the wrist, and the ulnar artery 912 runs between the ulna and the skin on the surface of the wrist. The radial artery 911 and the ulnar artery 912 branch off from the brachial artery (not shown) in the brachial artery.

As shown in FIGS. 1B, 2 and 3, the first electrode 121 and the second electrode 122 are arranged side by side in the circumferential direction of the wrist in the vicinity of the radial artery 911 on the palm side of the wrist. The electric potential linked to the electrocardiogram is detected from the radial artery 911. The third electrode 123 and the fourth electrode 124 are arranged side by side in the circumferential direction of the wrist in the vicinity of the ulnar artery 912 on the palm side of the wrist, and detect the potential linked to the electrocardiogram from the ulnar artery 912. As shown in FIG. 1 (C) and FIGS. 2 and 3, the fifth electrode 125 is arranged on the back side of the wrist and detects the bioreference potential. With such a configuration, the potential detected by at least one of the first electrode 121 or the second electrode 122 or at least one of the third electrode 123 or the fourth electrode 124 with the fifth electrode 125 as a reference potential is amplified. The electrocardiogram can be accurately obtained and the electrocardiographic waveform can be measured by performing the measurement with the passage of time by using (for example, an electric potential). Further, the fifth electrode 125 may be, for example, a ground potential, and by using this, the fluctuation of the reference potential for measurement can be suppressed, so that a T wave or the like detected by at least one of the first to fourth electrodes can be suppressed. It is possible to improve the detection accuracy of the electrocardiographic waveform accompanied by a minute change (inflection point) of.

Here, the number of electrodes for obtaining an electrocardiogram is not limited to five as described above, and may be appropriately increased or decreased as needed. A modification of the electrode will be described below.

<Electrode deformation example 1>
For example, if an electrocardiographic waveform with a slight change (inflection) such as a T wave can be sufficiently detected from at least one of the first electrode 121 and the fourth electrode 124, the configuration does not include the fifth electrode 125. There may be.

<Electrode deformation examples 2 and 3>
The first electrode 121 to the fourth electrode 124 can be appropriately arranged in the vicinity of either the radial artery 911 or the ulnar artery 912 of the subject, for example, the biometric information measuring device 100 of various sizes can be created. If there is, one for the radial artery 911 and one by either the first electrode 121 or the second electrode 122, or a configuration having any one of the first electrode 121 to the fourth electrode 124 (modification example 2). There may be a total of two configurations (modification 3), one for the ulnar artery 912 by either the three electrodes 123 or the fourth electrode 124.

<Electrode deformation example 4>
One set of the first electrode 121 and the second electrode 122 for the radial artery 911, one set of the third electrode 123 and the fourth electrode 124 for the ulnar artery 912, and so on (two in total). It may be the configuration of.

Here, in a configuration in which one set is provided for at least one of the radial artery 911 and the ulnar artery 912 as in the above-described embodiment and the present modification 4, for example, the potential difference between both electrodes in one set is calculated. It may be configured to be used. That is, for example, when the first arm portion 131 and the second arm portion 132 are elastically deformed and spread in at least the left-right direction, or when the biological information measuring device 100 rotates in the circumferential direction of the wrist and the position is displaced, the position is displaced from the artery. When the electrodes are separated, they become extremely close to 0, and the influence of noise is more likely to appear. Therefore, for example, when one electrode is provided for an artery, it is necessary to place it in an appropriate position. It will increase. On the other hand, by arranging one set of electrodes side by side in the circumferential direction of the wrist with respect to the artery, for example, even if one electrode is separated from the artery, the other electrode is arranged in the vicinity of the artery. Therefore, it is possible to improve the detection accuracy of the electrocardiographic waveform accompanied by a minute change (inflection point) such as a T wave. Further, although the detected potential may be small, instead of the potential difference, the average value of the potentials from both electrodes of one set may be calculated and used as the electrocardiographic potential. Further, although the determination configuration may be complicated, instead of the potential difference, the potential of either electrode of one set of both electrodes is compared with the reference potential for determination or the potentials of both electrodes are compared. May be selected as the electrocardiographic potential.

Further, in the case of acquiring two types, one for the radial artery 911 and the other for the ulnar artery 912, as in the above-described embodiment and modification 2, the average value of both is calculated and used as the electrocardiographic potential. , The potential (potential difference) of either of the two types of electrodes may be adopted for the detection of the electrocardiographic waveform by comparing with the reference potential for determination or comparing the potentials (potential difference) between the two.

Further, the skin temperature may be obtained by connecting a thermistor to at least one of the first electrode 121 and the sixth electrode 126. In particular, the fifth electrode 125 is preferable to other electrodes as an electrode provided with a thermistor in view of being provided on the upper part of the main body 101. FIG. 4 shows an example in which the thermistor 1252 is connected to the fifth electrode 125 provided on the back side surface 103 of the main body 101. For example, in the fifth electrode 125, the terminal 1251 may be connected to a reference potential (for example, the ground potential GND), and the thermistor 1252 may include a ground terminal 1253 and an output terminal 1254, respectively. The thermista 1252 may be connected to the fifth electrode 125 via, for example, a heat conductive adhesive 1255 having a high thermal conductivity, as illustrated in FIG. 4, or may be directly connected to the fifth electrode 125. (Especially, a recess is made in the back side of the fifth electrode 125 and a part of the thermista 1252 is inserted and fixed). As a result, the heat of the skin is transferred to the thermistor 1252 via the electrode that directly touches the skin of the subject (for example, the fifth electrode 125 illustrated in FIG. 4), so that the skin temperature of the subject can be measured. ..

As shown in FIG. 1C, the optical sensor module 111 includes a light emitting unit 112 and a light receiving unit 113. The light emitting unit 112 includes, for example, a green light emitting LED, and the light receiving unit 113 is composed of a photodiode capable of receiving light emitted from the light emitting unit 112. The light emitting unit 112 is not limited to the green light emitting LED, but may be a red light emitting LED, a blue light emitting LED, an infrared LED, or the like, and may include a plurality of the same color or a plurality of types of LEDs. More specifically, for example, the light emitting unit 112 may be configured to include two green light emitting LEDs, a red light emitting LED, and a total of four infrared LEDs. Further, the light receiving unit 113 may be provided with a number corresponding to each LED included in the light emitting unit 112, or may be provided in common for some LEDs. The light emitted from the light emitting unit 112 to the wrist is reflected inside the wrist and is received by the light receiving unit 113. The pulse waveform can be measured by the volume change of the blood vessel caused by the heartbeat of the heart of the person to be measured by the time change of the intensity of the light received by the light receiving unit 113. The pulse waveform that can be detected by this method is a photoelectric volumetric pulse waveform. The optical sensor module 111 is arranged on the back side of the wrist, and is arranged at a position facing the first electrode 121 and the like via the wrist. As a result, the measurement site of the electrocardiographic waveform measured by the first electrode 121 or the like and the photoelectric volume pulse waveform measured by the optical sensor module 111 can be separated from each other. Thereby, the ventricular systolic pulse wave propagation time PTT_SYS (Pulse Transit Time_Dialtic) and the ventricular diastolic pulse wave propagation time PTT_DIA, which will be described later, can be lengthened, and the reliability of measurement can be improved.

Next, the configuration and outline of the biometric information measurement system 1 including the server device 400 that calculates the biometric information of the person to be measured by the information from the biometric information measuring device 100 in the first embodiment using FIG. explain. Note that FIG. 5 is a block diagram of the biological information measurement system 1 of the present embodiment.

As shown in FIG. 5, the biometric information measurement system 1 of the present embodiment is composed of a biometric information measuring device 100, a terminal device 200, and a server device 400, and the terminal device 200 and the server device 400 are, for example, the Internet or a LAN. It is configured to be connectable to the network 300 such as. The biometric information measuring device 100 and the server device are provided by integrally configuring the biometric information measuring device 100 and the terminal device 200, or by providing the biometric information measuring device 100 with a network communication function that enables communication via the network 300. It may be configured to communicate between 400. Further, a part or all of the calculation process of the predetermined biological information (biological generation information) may be performed by the biological information measuring device 100 instead of the calculation by the server device 400. However, when the calculation is performed by the biological information measuring device 100, the calculation processing load becomes high, which may increase the size and cost of the biological information measuring device 100. Therefore, the calculation by the server device 400 is performed. Is more preferable.

The biological information measuring device 100 includes an electrocardiographic detection unit 110, a pulse wave detection unit 120, a measuring device control unit 140, a measuring device storage unit 150, a measuring device operation unit 160, and a measuring device communication unit 170. These functional units are realized by executing a predetermined program for the biometric information measuring device 100.

The biometric information includes electrocardiographic information and pulse wave information as biometric information, and blood pressure information as biogenic information obtained from these, but is not limited to these, and biometric information is measured by a known method. Examples include skin temperature information (body temperature information), acceleration information, and angular velocity information of the subject, and biogenerated data obtained from these biometric information include, for example, heartbeat information and blood of the subject. Oxygen amount information, maximum oxygen intake information, blood glucose level information, breathing rate, body temperature information, step count information, stride information, center of gravity position information, posture information, stress information, exercise amount information, exercise load information, movement distance information, movement speed Includes data such as information, activity amount information, and motion information of the attachment site such as a hand or leg.

The electrocardiographic detection unit 110 has, for example, the first electrode 121 and the second electrode 122 for detecting the electrocardiogram of the radial artery, the third electrode 123 and the fourth electrode 124 for detecting the electrocardiogram of the ulnar artery, and the reference potential. It is configured to include a fifth electrode 125 for making measurements.

The pulse wave detection unit 120 includes an optical sensor module 111. The optical sensor module 111 includes the light emitting unit 112 and the light receiving unit 113 described above.

The measuring device control unit 140 includes an electrocardiographic measurement control unit 141 and a pulse wave measurement control unit 142. The electrocardiographic measurement control unit 141 detects, for example, at least one of the difference between the detected potentials from the first electrode 121 and the second electrode 122, or the difference between the detected potentials from the third electrode 123 and the fourth electrode 124. , Amplifies using the reference potential of the fifth electrode 125, and adds time information to obtain an electrocardiographic waveform. The pulse wave measurement control unit 142, for example, controls the light emission of the light emitting unit 112 of the pulse wave detection unit 120, and also receives the detection signal from the light receiving unit 113.

The measuring device storage unit 150 stores, for example, the electrocardiographic information received by the electrocardiographic measurement control unit 117, and stores the pulse wave information received by the pulse wave measurement control unit 118. The electrocardiographic information includes electrocardiographic waveform information related to an electrocardiographic waveform in which electrocardiographic information received by the measuring device control unit 140 is continuously arranged, and measurement time information of the electrocardiographic waveform is added. The pulse wave information is information about a photoelectric volumetric pulse waveform in which pulse wave information received by the pulse wave measurement control unit 142 is continuously arranged, and measurement time information of the photoelectric volumetric pulse waveform is added. Electrocardiographic information and pulse wave information are transmitted to the terminal device 200 via the measuring device communication unit 170 described later, but when the transmission frequency is lowered for power saving or the like, or communication with the terminal device 200 is performed. It is possible to temporarily store the data even when the connection is disconnected.

The measuring device operation unit 160 is an operation unit for the person to be measured or the like to operate the power supply of the biological information measuring device 100, start or stop the measurement, and the like.

The measuring device communication unit 170 is a communication interface for communicating between the biological information measuring device 100 and an external device such as a terminal device 200. The measuring device communication unit 170 may, for example, receive electrocardiographic information received by the electrocardiographic measurement control unit 141, pulse wave information received by the pulse wave measurement control unit 142, or electrocardiographic information or pulse stored in the measuring device storage unit 150. Wave information is transmitted to the terminal device 200, and information for operating the biological information measuring device 100 is received from the terminal device 200. As the communication means of this embodiment, Bluetooth (registered trademark) is used. As other communication means, short-range wireless communication (Near Field radio Communication = NFC), Afero (registered trademark), Zigbee (registered trademark), Z-Wave (registered trademark), wireless LAN, or the like may be used. Alternatively, the connection may be made by wire using the sixth electrode 126.

The terminal device 200 includes a terminal device control unit 211, a terminal device storage unit 212, and a terminal device communication unit 213. The terminal device 200 is an information processing device such as a smartphone, a mobile phone, a PHS, or a PDA. Further, the terminal device dedicated to the biological information measuring device may be used instead of the general-purpose device such as a smartphone. These functional units are realized by executing a predetermined program of the terminal device 200.

The terminal device control unit 211 controls the storage of biometric information such as electrocardiographic information and pulse wave information received from the biometric information measuring device 100 by the terminal device communication unit 213 to the terminal device storage unit 212, or stores the terminal device. Biological information such as electrocardiographic information and pulse wave information is transmitted from the unit 212 to the server device 400, and biogenerated information calculated based on the biometric information is received by the server device 400.

The terminal device storage unit 212 stores biological information such as electrocardiographic information and pulse wave information received by the terminal device communication unit 213.

The terminal device communication unit 213 is a communication interface for communicating with the biometric information measuring device 100 and the server device 400. It receives biometric information such as electrocardiographic information and pulse wave information transmitted from the biometric information measuring device 100, and also sets information to the biometric information measuring device 100 and biometric information such as electrocardiographic information and pulse wave information. The request signal of is transmitted. Further, biometric information such as electrocardiographic information and pulse wave information is transmitted to the server device 400, and a request signal for biometric information such as electrocardiographic information and pulse wave information is received from the server device 400. In the present embodiment, the communication with the biological information measuring device 100 is the above-mentioned Bluetooth (registered trademark), but other communication means may be used. Further, communication with the server device 400 can be performed via a network 301 such as the Internet via a wireless LAN.

The terminal device display unit 214 displays biometric information and abnormality notifications transmitted from the biometric information measuring device 100 or the server device 400, for example, in accordance with the rules of an application executed on the terminal device 200.

The server device 400 includes a server device control unit 411, a server device communication unit 412, and a server device storage unit 413.

The server device control unit 411 includes a pulse wave propagation time calculation unit 421 which is a first calculation unit and a biometric information calculation unit 422 which is a second calculation unit. The server device control unit 411 (third calculation unit) calculates second-order differential data from the photoelectric volume pulse waveform data. The pulse wave propagation time calculation unit 421 detects R wave and T wave from the waveform profile in the electrocardiographic information described later, and also detects P wave and D wave from the waveform profile in the photoelectric positive displacement pulse waveform data. Based on the information, the ventricular contractile phase pulse wave propagation time PTT_SYS and the ventricular diastolic phase pulse wave propagation time PTT_DIA are calculated. Further, the biometric information calculation unit 422 includes acceleration pulse wave characteristic information based on the second-order differential data calculated by the server device control unit 411, ventricular systolic pulse wave propagation time PTT_SYS, and ventricular diastolic pulse wave propagation time PTT_DIA. From, the blood pressure information is calculated. Further, the server device control unit 411 determines the health condition of the person to be measured based on the blood pressure information, and notifies the terminal device 200 of the abnormality. The pulse wave propagation time calculation unit 421 may use the first-order differential data or the second-order differential data of the photoelectric positive volume pulse waveform data in detecting the R wave and the T wave.

Further, the biometric information calculation unit 422 is, for example, the interval of QRS waves in the electrocardiographic waveform data (for example, the electrocardiographic waveform data of FIG. 6) measured by the biometric information measuring device 100 worn by the subject at rest. From the above, heartbeat information can be obtained as biometric information (biologically generated information).

Further, the biological information calculation unit 422 obtains temperature information from the skin temperature information of the subject measured by a temperature sensor (thermista or the like) of the biological information measuring device 100 worn by the subject, for example, to generate biological information (biological generation). Information) can be obtained.

Further, the biometric information calculation unit 422 uses, for example, a calculation method known from the waveform data of the acceleration data measured by the biometric information measuring device 100 worn on the wrist of the person to be measured alone or in combination. Walking speed information can be obtained as biometric information (biological generation information) by (for example, averaging or weighting). For example, walking speed information biometric information (biological body) can be obtained by integrating acceleration data at predetermined time intervals. It can be obtained as generated information).

Further, the biometric information calculation unit 422 uses, for example, a calculation method known from the waveform data of acceleration data measured by the biometric information measuring device 100 worn on the wrist of the person to be measured alone or in combination. Stride information can be obtained as biometric information (biologically generated information) by averaging or weighting (for example, averaging, weighting, etc.). For example, the interval of one step based on the timing when the acceleration component in the traveling direction is the smallest or the timing when the acceleration component is switched in the opposite direction, the timing when the acceleration component in the direction perpendicular to the traveling direction is the smallest or the timing when the acceleration component is switched up and down, etc.) Therefore, if time information is further used, stride information can be obtained as biometric information (biologically generated information). Alternatively, for example, when the ground is kicked out, the acceleration component in the kicking direction is synthesized, so that it is also possible to determine the interval of one step at the timing of occurrence of the acceleration component in the direction.

Further, the biometric information calculation unit 422 is, for example, from the acceleration data and the angular velocity data measured by the biometric information measuring device 100 worn by the person to be measured, the portion where the biometric information measuring device 100 is attached (for example, the wrist or the wrist). It is possible to obtain motion information (biological generation information) as to how fast and at what angle the ankle (such as an ankle) is moving.

Further, the biometric information calculation unit 422 frequency-analyzes the acceleration data measured by, for example, the biometric information measuring device 100 that is worn on a daily basis. The activity amount information can be obtained as biological information (biological generation information) by calculating according to predetermined conditions such as what percentage of the day the above activities occupy.

Further, the biometric information calculation unit 422 can specify the acceleration data during exercise including walking by a known calculation method or the like from the acceleration data measured by the biometric information measuring device 100 which is worn on a daily basis, for example. Therefore, the momentum information can be obtained as biometric information (biologically generated information) by calculating under predetermined conditions using, for example, frequency analysis. Further, by further using additional information such as angular velocity information, it is possible to obtain more accurate momentum information.

Further, the biometric information calculation unit 422, for example, with respect to the activity amount information and the exercise amount information derived from the acceleration data measured by the biometric information measuring device 100 which is worn on a daily basis, for example, the heartbeat that increases with the exercise load. By weighting with information, exercise load information can be obtained as biometric information (biologically generated information). Further, for example, if vector information of acceleration data is added, state information such as walking environment (hill, stairs, etc.) and posture (standing position, sitting position, etc.) can be specified, and the state information may be further used. Further, by further using additional information such as angular velocity information, it is possible to obtain more accurate exercise load amount information.

Further, the biological information calculation unit 422 uses the above-mentioned resting heart rate information, for example, to obtain maximal oxygen uptake information by a known mathematical formula such as VO ₂ max = 15 × (220-age) ÷ resting heart rate. It can be obtained as information (biologically generated information).

Further, it is based on, for example, biometric information, biogenerated information (for example, heartbeat information, blood pressure information, etc.) generated based on the biometric information and positive biometric information (for example, based on known medical equipment) by a known learning device or the like. A machine learning model is created in advance based on the teacher data associated with the correspondence with the heartbeat information, blood pressure information, etc. (for example, information indicating the degree and range of the error may be included), and the biometric information. The calculation unit 422 may generate biometric information using the determination using the machine learning model as the above-mentioned predetermined calculation (analysis).

The server device communication unit 412 is a communication interface for communicating with the terminal device 200 via a network 300 such as the Internet. It receives biometric information such as electrocardiographic information and pulse wave information transmitted from the terminal device 200, and also transmits a request signal for biometric information such as electrocardiographic information and pulse wave information to the terminal device 200. .. In addition, an abnormality notification is transmitted to the terminal device 200.

The server device storage unit 413 stores biological information such as electrocardiographic information and pulse wave information received by the server device communication unit 412. In addition, the biological information calculation unit 422 stores the calculated blood pressure information.

<ECG waveform, photoelectric volume pulse waveform, velocity pulse waveform, acceleration pulse waveform, blood pressure information calculation method>
FIG. 6 shows the electrocardiographic waveform and the photoelectric volume pulse waveform of the non-measurer measured by the biological information measuring device 100, and the velocity pulse waveform and the acceleration pulse waveform calculated by the server device 400. From the top of FIG. 6, the electrocardiographic waveform, the photoelectric volumetric pulse waveform, the velocity pulse waveform, and the acceleration pulse waveform are arranged in this order. The vertical axis shows the intensity of each waveform, and the electrocardiographic waveform and the photoelectric volume pulse waveform are represented by MV indicating the potential. The horizontal axis shows the passage of time, and shows the passage of time from left to right.

An electrocardiographic waveform is a waveform showing a periodic change in an electrical signal that causes a person's heart to beat. In the electrocardiographic waveform, the names of P wave, Q wave, R wave, S wave, and T wave are assigned to the inflection points of the shape, respectively, and indicate one cycle of the heartbeat. The P wave represents the atrial contraction, the Q wave, the R wave, and the S wave represent the state of ventricular contraction, and the T wave represents the start of ventricular dilation.

The photoelectric volume pulse waveform is a waveform showing changes in blood pressure and volume in the peripheral vascular system accompanying the beating of the human heart. In the photoelectric volume pulse waveform, the names of A wave, P wave, V wave, and D wave are assigned to the inflection points of the shape, respectively, and indicate one cycle of the heartbeat. Using the A wave as the reference point at the time when the arterial pulse wave is generated, the P wave is the Percussion wave (shock wave) generated by the ejection of the left ventricle, the V wave is the Valley wave (wave due to the overlapping uplift) generated when the aortic valve is closed, and the D wave. Indicates a Dictric wave (overlapping wave) which is a reflected vibration wave.

The velocity pulse waveform is the first derivative of the photoelectric volume pulse waveform with respect to time. The acceleration pulse waveform is a first-order derivative of the velocity pulse waveform, that is, a second-order derivative of the photoelectric volume pulse waveform. As shown in FIG. 6, the acceleration pulse waveform has a wave (initial contraction positive wave), b wave (initial contraction negative wave), c wave (mid-contraction re-rise wave), and d wave (contraction) at each peak of the waveform. The names of the late re-descending wave), the e wave (extended early positive wave), and the f wave (extended early negative wave) are assigned. The ratio of the intensity of the b wave to the intensity of the a wave and the ratio of the intensity of the f wave to the intensity of the e wave are parameters indicating the elasticity, that is, the elasticity of the blood vessel, respectively. The main vascular components are vascular endothelium, elastin, collagen, and smooth muscle. Each of these components has different properties, and collagen and elastin have a strong influence on the elasticity of blood vessels at the maximum blood pressure and the minimum blood pressure, respectively. Therefore, the elasticity that differs depending on the blood pressure value is indicated by the parameters of the ratio of the intensity of the b wave to the intensity of the a wave (b / a) and the ratio of the intensity of the f wave to the intensity of the e wave (f / e). These values also fluctuate depending on the influence of age, gender, and environment variables (temperature, etc.). Therefore, the values of (b / a) and (f / e) can be calculated as the characteristic information of the acceleration pulse waveform.

As shown in FIG. 6, the time difference between the time Tr at which the R wave is generated and the time Tp at which the P wave is generated is the ventricular systolic pulse wave propagation time PTT_SYS. The time of the difference between the time Tt in which the T wave is generated and the time Td in which the D wave is generated is the ventricular diastolic pulse wave propagation time PTT_DIA. That is, as shown by Eqs. (1) and (2) from the time Tr of the R wave and the time Tt of the T wave of the electrocardiographic waveform, and the time Tp of the T wave and the time Td of the D wave of the photoelectric systolic waveform. In addition, the ventricular systolic pulse wave propagation time PTT_SYS and the ventricular diastolic pulse wave propagation time PTT_DIA can be calculated.

PTT_SYS = Tp-Tr ... (1)

PTT_DIA = Td-Tt ... (2)

The first electrode 121 to the fourth electrode 124 for measuring the electrocardiographic waveform and the optical sensor module 111 for measuring the photoelectric volumetric pulse waveform are opposed to each other via the wrist, and the electrocardiographic waveform is detected by separating them from each other. The site and the measurement site of the photoelectric volume pulse waveform will be separated. Therefore, by causing a time lag in which each characteristic waveform is generated, the absolute calculation time of the ventricular systolic pulse wave propagation time PTT_SYS and the ventricular diastolic pulse wave propagation time PTT_DIA can be lengthened. Therefore, when the change information of the ventricular systolic pulse wave propagation time PTT_SYS and the ventricular diastolic pulse wave propagation time PTT_DIA is obtained, the accuracy of the change information can be improved.

Here, the formula for calculating blood pressure will be described.

From the following equation (3) of pulse wave velocity (Moens-Korteweg equation), the relationship between the pulse wave velocity and the Young's modulus of the arterial wall is shown.

L / T_PTT = √ (E ・ h / (2 ・ r ・ ρ)) ・ ・ ・ (3)

Each parameter of the formula (3) is L: distance between measurements, T_PTT: pulse wave propagation time, r: blood vessel inner diameter, E: blood vessel Young's modulus, h: blood vessel thickness, ρ: blood density.

It is known that Young's modulus and blood pressure value are correlated.

E = E ₀・ exp (α ・ P) ・ ・ ・ (4)

Can be indicated by. Here, P: blood pressure value, α: constant, E ₀ : initial value.

From equations (3) and (4)

P = (-2 ・ ln (T_PTT) + ln (2 ・ r ・ ρ ・ L ² / (E ₀・ h))) / α ・ ・ ・ (5)

Can be derived. ln indicates the natural logarithm. At this time, since "r · ρ" is proportional to the blood volume at the measurement site, it can be indicated by a high value (Vp, Vd) indicated by the photoelectric volume pulse waveform. Further, since "E ₀ · h" is a value proportional to the elasticity of the blood vessel, it can be replaced by using the parameters (b / a) and (f / e) indicating the elasticity.

Therefore, the systolic blood pressure BP_SYS (Blood Pressure_Systic) and the diastolic blood pressure BP_DIA (Blood Pressure_Diastolic) can be represented by the following equations (6) and (7).

BP_SYS = A1 · ln (PTT_SYS) + A2 · ln (Vp) + A3 · ln (b / a) + A4 ... (6)

BP_DIA = A5 · ln (PTT_DIA) + A6 · ln (Vd) + A7 · ln (f / e) + A8 ... (7)

A1 to A8 are constants determined by conditions. The systolic blood pressure BP_SYS that can be calculated by Eq. (6) is the natural logarithm of the ventricular systolic pulse wave propagation time PTT_SYS multiplied by the constant A1 and the natural logarithm of the intensity Vp of the P wave multiplied by the constant A2. It can be obtained by multiplying the natural logarithm of (b / a) by the constant A3 and the sum of the constants A4. The diastolic blood pressure BP_SYS that can be calculated by Eq. (7) is the natural logarithm of the ventricular systolic pulse wave propagation time PTT_DIA multiplied by the constant A5 and the natural logarithm of the intensity Vd of the D wave multiplied by the constant A6. It can be obtained by multiplying the natural logarithm of (f / e) by the constant A7 and the sum of the constants A8. It is possible to obtain the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA by obtaining each constant depending on the characteristics of the device and the person to be measured. However, when confirming the changes in the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA, it is not necessary to determine all the constants, and while substituting the provisional numerical values, the information on the systolic blood pressure BP_SYS and the information on the diastolic blood pressure BP_DIA are used. It is possible to get a value. The natural logarithm of the intensity Vp of the P wave and the natural logarithm of the intensity Vd of the D wave are terms in consideration of the influence of blood density. Further, the natural logarithm of (b / a) and the natural logarithm of (f / e) are terms in consideration of the influence of the Young's modulus of the arterial wall. Therefore, depending on the measurement conditions, information on the systolic blood pressure BP_SYS and information on the diastolic blood pressure BP_DIA may be calculated by selecting one of the terms and making the other term constant.

<Processing flow>
Next, the operation of the biological information measurement system 1 according to the first embodiment of the present invention will be described with reference to the flowchart illustrated in FIG. The flowchart of FIG. 7 shows the related state of each operation of the biological information measuring device 100, the terminal device 200, and the server device 400.

In step S101, the biological information measuring device 100 loops until the measured person starts the measurement and performs the end operation until the step S122.

In step S102, the electrocardiographic measurement control unit 141 detects the electrocardiogram from the first electrode 121 to the fourth electrode 124. In addition, step S102 and step S104 and step S103 and step S105 are processed in parallel by parallel processing.

In step S103, the electrocardiographic measurement control unit 141 generates an electrocardiographic waveform from the time change of the electrocardiogram detected in step S102.

In step S104, the pulse wave measurement control unit 142 controls the optical sensor module 111 to detect the pulse wave. Specifically, the light emitting LED of the light emitting unit 112 is made to emit light and irradiates the wrist. The light receiving unit 113 receives the light reflected from the wrist. The light receiving unit 113 converts the received light into an electric signal by the photodiode of the light receiving unit 113, and transmits the pulse wave information to the pulse wave measurement control unit 142.

In step S105, the pulse wave measurement control unit 142 generates a photoelectric volumetric pulse waveform from the time change of the pulse wave information based on the pulse wave detected in step S104.

In step S106, the measuring device control unit 140 adds the detected time as the measurement time to the electrocardiographic waveform generated in step S103 and the photoelectric plethysmogram waveform generated in step S105, respectively, and adds the electrocardiographic information and the pulse. The wave information is stored in the measuring device storage unit 150.

In step S107, the measuring device control unit 140 determines the presence / absence of the measuring device data transmission trigger. When the measuring device data transmission trigger is “Yes”, that is, “Y”, the process proceeds to step S107, and when “No”, that is, “N”, the process proceeds to step S122. The measuring device data transmission trigger is an internal parameter in the biometric information measuring device 100, and when the electrocardiographic information and the pulse wave information are constantly transmitted from the biometric information measuring device 100 to the terminal device 200, the parameter is always ". Yes, that is, it is set to "1". When the electrocardiographic information and the pulse wave information are periodically transmitted from the biological information measuring device 100 to the terminal device 200, the measuring device data communication trigger is set to "1" by the internal counter at the set timing. Set. Further, the measuring device data communication trigger may be set to "1" at the request of the terminal device 200.

In step S108, the measuring device control unit 140 transmits the electrocardiographic information and the pulse wave information stored in the measuring device storage unit 150 to the terminal device 200.

In step S109, the terminal device control unit 211 stores the electrocardiographic information and the pulse wave information received by the terminal device communication unit 213 in the terminal device storage unit 212.

In step S110, the terminal device control unit 211 determines the presence / absence of the terminal device data transmission trigger. When the terminal device data transmission trigger is "Yes", that is, "Y", the process proceeds to step S111, and when "No", that is, "N", the process proceeds to step S121. The terminal device data transmission trigger is an internal parameter in the terminal device 200, and when the electrocardiographic information and the pulse wave information are constantly transmitted from the terminal device 200 to the server device 400, the parameter is always "Yes", that is, "Yes". 1 "is set. When the electrocardiographic information and the pulse wave information are periodically transmitted from the terminal device 200 to the server device 400, the internal counter is set so that the terminal device data communication trigger becomes "1" at the set timing. .. Further, the terminal device data communication trigger may be set to "1" at the request of the server device 400.

In step S111, the terminal device control unit 211 transmits the electrocardiographic information and the pulse wave information stored in the terminal device storage unit 212 to the server device 400.

In step S112, the server device control unit 411 stores the electrocardiographic information and the pulse wave information received by the server device communication unit 412 in the server device storage unit 413.

In step S113, the server device control unit 411 calculates the pulse wave propagation time from the electrocardiographic information and the pulse wave information stored in the server device storage unit 413. The specific operation procedure will be described below. The pulse wave propagation time calculation unit 421 extracts the waveform profile in the electrocardiographic information and the waveform profile in the pulse wave information whose measurement timings are close to each other. Next, the pulse wave propagation time calculation unit 421 detects the R wave and the T wave from the waveform profile in the electrocardiographic information, and stores the detected time information of the R wave and the T wave as Tr and Tt. Similarly, the pulse wave propagation time calculation unit 421 detects the P wave and the D wave from the waveform profile in the photoelectric plethysmogram waveform data, and sets the detected time information of the P wave and the D wave as Tp and Td. Make a memory. At the same time, the intensity Vp of the P wave and the intensity Vd of the D wave are detected and stored. As shown in FIG. 6, the pulse wave propagation time calculation unit 421 calculates the difference between the time information Tr in which the R wave is generated and the time information Tp in which the P wave is generated, and calculates the ventricular systolic pulse wave propagation time PTT_SYS. .. Similarly, the difference between the time information Tt in which the T wave is generated and the time information Td in which the D wave is generated is calculated, and the ventricular diastolic pulse wave propagation time PTT_DIA is calculated.

In step S114, the server device control unit 411 calculates the second-order differential data from the photoelectric volume pulse waveform data stored in the server device storage unit 413. Specifically, as shown in FIG. 6, the first-order differential of the photoelectric volume pulse waveform data is performed, and the first-order differentiated data is further differentiated to obtain the second-order differential data. The waveform obtained by differentiating the pulse wave to the second order is called the acceleration pulse waveform.

In step S115, the server device control unit 411 calculates the characteristic information of the acceleration pulse waveform from the second-order differential data obtained in step S114. The characteristic information of the acceleration pulse waveform is obtained by performing a calculation from the intensities of the a wave, the b wave, the e wave, and the f wave indicating the peak of the acceleration pulse waveform described above.

In step S116, the server device control unit 411 performs blood pressure information from the characteristic information of the ventricular systolic pulse wave propagation time PTT_SYS obtained in step S113, the ventricular diastolic pulse wave propagation time PTT_DIA, and the acceleration pulse waveform obtained in step S115. Perform the operation of. The blood pressure information related to the maximum blood pressure is calculated from the ventricular systolic pulse wave propagation time PTT_SYS and the acceleration pulse wave characteristic information, and the blood pressure information related to the minimum blood pressure is calculated from the ventricular diastolic pulse wave propagation time PTT_DIA and the acceleration pulse waveform characteristic information. conduct. The calculation is performed using the above-mentioned equations (6) and (7).

In step S117, the server device control unit 411 stores the blood pressure information calculated in step S116 in the server device storage unit 413.

In step S118, the server device control unit 411 analyzes the change state of the blood pressure information stored in the server device storage unit 413. If it is determined that the changed state is deterioration of the health condition of the subject, the determination flag is set to "Yes" as an abnormality. The determination flag is an internal parameter of the server device 400.

In step S119, the server device control unit 411 determines whether or not the determination flag is "Yes". If "Yes", the process proceeds to step S120, and if "No", the flow ends.

In step S120, the server device control unit 411 notifies the terminal device 200 of the abnormality via the server device communication unit 412.

In step S121, the terminal device control unit 211 controls the terminal device display unit 214 to display to notify that there is an abnormality in the health condition based on the abnormality notification received by the terminal device communication unit 213. As a result, the terminal device 200 can notify the person to be measured of the abnormality in the health condition.

In step S122, the biometric information measuring device 100 loops with step S101 until the power of the biometric information measuring device 100 is turned off or the measuring device control unit 140 performs an operation to end the measurement.

<Explanation of effect>
As described above, the biological information measuring device 100 of the present invention has the first arm portion 131 and the second arm portion 132 in particular, so that it is possible to cope with a person to be measured having various arm thicknesses. The detection accuracy of the electrocardiographic waveform can be improved.

Although some embodiments of the present invention have been described above, these embodiments can be implemented in various other embodiments, and various omissions, replacements, and modifications are made without departing from the gist of the invention. It can be performed. These embodiments and variations thereof shall be included in the scope of the invention described in the claims and the equivalent scope thereof, as well as in the scope and gist of the invention.

1 ... Biometric information measurement system 100 ... Biometric information measurement device 200 ... Terminal device 300 ... Network 400 ... Server device

Claims (5)

It is a biological information measuring device worn by the person to be measured.
The biological information measuring device has at least a main body and has at least a main body.
The main body portion includes a first electrode for measuring electrocardiographic information and a second electrode for acquiring a reference voltage to be compared with the electrocardiographic information.
The first electrode for measuring the electrocardiographic information is arranged on the palm side of the wrist of the person to be measured.
The second electrode that acquires the reference voltage is arranged on the back side of the wrist.
Further having a thermistor for measuring the skin temperature of the person to be measured via the second electrode for acquiring the reference voltage.
A biological information measuring device characterized by this. The second electrode that acquires the reference voltage is connected to the ground potential.
The biometric information measuring device according to claim 1. The main body portion includes a first arm portion and a second arm portion that are curved from the upper portion of the main body portion to the lower portion of the main body portion and extend to the left and right, respectively.
The first arm portion and the end portion of the second arm portion are separated from each other.
The first electrode for measuring the electrocardiographic information is provided on at least one end side of the first arm portion and the second arm portion.
The second electrode for acquiring the reference voltage is provided on the upper side of the main body.
The biometric information measuring device according to claim 1 or 2 . The thermistor is connected to the second electrode that acquires the reference voltage via a heat conductive adhesive.
The biometric information measuring device according to any one of claims 1 to 3 . The thermistor is connected with a recess on the back side of the second electrode that acquires the reference voltage.
The biometric information measuring device according to any one of claims 1 to 4 .

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