JP7025999B2 - Syringe adapter, drug infusion device and drug infusion system - Google Patents

Description

The present application relates to syringe adapters, drug injecting devices and drug injecting systems for injecting medical drugs.

Patients suffering from certain diseases may need to inject drugs such as insulin, growth hormone, etc. several times a day, for example. Since the patient injects such a drug by himself / herself, various drug injection devices have been realized.

Such a drug injecting device performs a needle-piercing operation into the skin of a patient and an injecting operation of a drug by moving a piston of a syringe.

There is a demand for a drug injection device that is easier to operate. One non-limiting exemplary embodiment of the present application provides a drug infusion device, a drug infusion system, and a syringe adapter used for these, which are excellent in operability.

The syringe adapter of the present disclosure is a syringe holding member having a first insertion port and a first tip opening, and a first columnar space located between the first insertion port and the first tip opening, and is an injection. A syringe holding member having a needle and a stopper and accommodating a syringe filled with a drug in the first columnar space with at least a part of the injection needle protruding from the first tip opening, a second insertion port, and a second insertion port. Located between the second tip opening and the second insertion port and the second tip opening, it has an inner surface that defines a second columnar space into which the syringe holding member is inserted, from the second tip opening. An outer cylinder that movably supports the syringe holding member between a needle insertion position where at least a part of the injection needle protrudes and a needle extraction position where the injection needle does not protrude from the second tip opening, and the outer cylinder. A needle guard that is arranged in the second columnar space of the above and is movable between an initial position in which at least a part protrudes from the second tip opening and a pushing position in which the needle guard does not protrude, and the needle guard in the direction of the initial position. When the needle guard is in the initial position and the syringe holding member is in the needle removal position, the syringe holding member is in a locked state with respect to the outer cylinder. When the needle guard is in the pushing position and the syringe holding member is in the needle pulling position, the syringe holding member is in the unlocked state with respect to the outer cylinder, and the needle guard is pushed in from the initial position. When the syringe holding member moves from the needle pulling position to the needle piercing position after moving to the position, then the syringe holding member returns to the needle pulling position, and the needle guard returns to the initial position, the above. The needle guard is locked with respect to the syringe holding member.

The drug injection device of the present disclosure includes an outer case having an adapter space to which the syringe adapter can be mounted, an adapter opening communicating with the adapter space, and a cover for opening and closing the adapter opening, a piston, and a piston shaft of the piston. The fourth engagement member provided on the piston gear to be driven in the direction, the piston and the gearbox supporting the piston gear, and the syringe holding member of the syringe adapter connected to the gearbox and inserted into the adapter space. A syringe lock member having a sixth engaging structure that engages with the combined structure is included, the syringe holding member is moved between the needle insertion position and the needle removal position, and the stopper is advanced by the piston. A drive unit that includes a piston unit, a needle extraction motor, and at least one gear to drive the piston unit in the direction of the piston axis, an injection motor that drives the piston gear, and controls the drive unit and the injection motor. It is provided with a control unit, a memory, and a notification device.

The drug injection system of the present disclosure includes the syringe adapter and the drug injection device.

According to the present disclosure, a drug injection device having excellent operability, a drug injection system, and a syringe adapter used for these are provided.

FIG. 1A is a perspective view showing the appearance of a drug injection system 300 including a syringe adapter 100 and a drug injection device 200. FIG. 1B is a perspective view of a drug injection device 200 equipped with a syringe adapter 100. FIG. 2 is an exploded perspective view of the syringe adapter 100 containing the syringe 10. FIG. 3 is an exploded perspective view of the syringe 10. FIG. 4A is a perspective view of the outer cylinder 120 of the syringe adapter 100. FIG. 4B is a perspective view of the needle guard 130 of the syringe adapter 100. FIG. 4C is a perspective view of the syringe holding member 180 of the syringe adapter 100. FIG. 5A is a perspective view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in a state that can be taken while being attached to the drug injection device 200. FIG. 5B is a cross-sectional view of the syringe adapter 100 in the state shown in FIG. 5A. FIG. 5C is a side view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in the state shown in FIG. 5A. FIG. 6A is a perspective view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in a state that can be taken while being attached to the drug injection device 200. FIG. 6B is a cross-sectional view of the syringe adapter 100 in the state shown in FIG. 6A. FIG. 6C is a side view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in the state shown in FIG. 6A. FIG. 7A is a perspective view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in a state that can be taken while being attached to the drug injection device 200. FIG. 7B is a cross-sectional view of the syringe adapter 100 in the state shown in FIG. 7A. FIG. 7C is a side view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in the state shown in FIG. 7A. FIG. 8A is a perspective view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in a state that can be taken while being attached to the drug injection device 200. FIG. 8B is a cross-sectional view of the syringe adapter 100 in the state shown in FIG. 8A. FIG. 8C is a side view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in the state shown in FIG. 8A. FIG. 9A is a perspective view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in a state that can be taken while being attached to the drug injection device 200. 9B is a cross-sectional view of the syringe adapter 100 in the state shown in FIG. 9A. 9C is a side view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in the state shown in FIG. 9A. FIG. 10A is a perspective view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in a state that can be taken while being attached to the drug injection device 200. FIG. 10B is a cross-sectional view of the syringe adapter 100 in the state shown in FIG. 10A. FIG. 10C is a side view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in the state shown in FIG. 10A. FIG. 11A is a perspective view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in a state that can be taken while being attached to the drug injection device 200. 11B is a cross-sectional view of the syringe adapter 100 in the state shown in FIG. 11A. 11C is a side view of the syringe adapter 100 in which the outer cylinder 120 is shown by a broken line in the state shown in FIG. 11A. FIG. 12 is a perspective view of the main unit 202 of the drug injection device 200. FIG. 13 is a block diagram showing an example of the circuit configuration of the drug injection system 300. FIG. 14A is a perspective view of the drive device of the main unit 202. FIG. 14B is a perspective view of the drive device of the main unit 202. FIG. 15A is a perspective view of the drive device of the piston unit 210. FIG. 15B is a perspective view of the drive device of the piston unit 210. FIG. 16A is a perspective view of the drive device of the piston unit 210. FIG. 16B is a perspective view of the drive device of the piston unit 210. FIG. 17A is a perspective view of a main part of the piston unit 210 that supports the syringe adapter 100. FIG. 17B is a perspective view of a main part of the piston unit 210 that supports the syringe adapter 100. FIG. 18A is a perspective view of the adapter lock mechanism 240. FIG. 18B is a perspective view of the adapter lock mechanism 240. FIG. 18C is a cross-sectional view of the adapter lock mechanism 240. FIG. 19A is a vertical sectional view of the drug injection device 200. FIG. 19B is a horizontal sectional view of the drug injection device 200. FIG. 20A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 20B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 20A. FIG. 21A is a vertical sectional view of the drug injection device 200 in one state during use. 21B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 21A. FIG. 22A is a vertical sectional view of the drug injection device 200 in one state during use. 22B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 22A. FIG. 23A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 23B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 23A. FIG. 24A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 24B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 24A. FIG. 25A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 25B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 25A. FIG. 26A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 26B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 26A. FIG. 27A is a vertical sectional view of the drug injection device 200 in one state during use. 27B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 27A. FIG. 28A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 28B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 28A. FIG. 29A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 29B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 29A. FIG. 30A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 30B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 30A. FIG. 31A is a vertical sectional view of the drug injection device 200 in one state during use. FIG. 31B is a horizontal sectional view of the drug injection device 200 in the state shown in FIG. 31A. FIG. 32A is a diagram showing the arrangement of the adapter mounting detector. FIG. 32B is a diagram showing the arrangement of the adapter mounting detector. FIG. 33 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 34 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 35 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 36 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 37 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 38 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 39 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 40 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 41 is a perspective view of the drug injection device 200 in one state during operation of the drug injection system 300. FIG. 42 is a flowchart showing the operation of the drug injection system. FIG. 43 is a flowchart showing the operation of the drug injection system. FIG. 44 is a flowchart showing the operation of the drug infusion system. FIG. 45 is a flowchart showing the operation of the drug injection system. FIG. 46 is a flowchart showing the operation of the drug injection system. FIG. 47 is a flowchart showing the operation of the drug injection system. FIG. 48 is a flowchart showing the operation of the drug infusion system. FIG. 49 is a flowchart showing the operation of the drug injection system. FIG. 50 is a flowchart showing the operation of the drug injection system. FIG. 51 is a flowchart showing the operation of the drug injection system. FIG. 52 is a flowchart showing the operation of the drug injection system.

It is preferable that the drug injecting device used for the patient to inject the drug by himself / herself can be used appropriately without requiring skill. Further, it is preferable that the operation is easy, the drug injection device is not large, and the structure is simple.

The inventor of the present application has conceived a novel drug injecting device that is easy to operate so that a patient can inject himself / herself using the drug injecting device. The syringe adapter used in the drug injection device of the present disclosure suppresses the possibility that the injection needle is exposed from the adapter and touched by the operator due to an erroneous operation or the like, in view of the fact that the syringe with the injection needle is housed. .. In addition, the drug injection device is compatible with this syringe adapter, and by equipping it with various detectors, the drug injection device itself can self-manage the operating status of the device, providing easy-to-understand operability for the operator. offer. The outline of the syringe adapter, the drug injecting device and the drug injecting system of the present disclosure is as follows.

[Item 1]
A syringe holding member having a first insertion slot and a first tip opening and a first columnar space located between the first insertion slot and the first tip opening, having an injection needle and a stopper, and a drug. A syringe holding member for accommodating a syringe filled with a syringe in the first columnar space with at least a part of an injection needle protruding from the first tip opening.
It has an inner surface that is located between the second insertion slot and the second tip opening and the second insertion slot and the second tip opening and defines a second columnar space into which the syringe holding member is inserted. An outer cylinder that movably supports the syringe holding member between a needle insertion position in which at least a part of the injection needle protrudes from the second tip opening and a needle extraction position in which the injection needle does not protrude from the second tip opening. When,
A needle guard arranged in the second columnar space of the outer cylinder and movable between an initial position in which at least a part protrudes from the second tip opening and a pushing position in which the outer cylinder does not protrude.
A spring that urges the needle guard in the direction of the initial position,
Equipped with
When the needle guard is in the initial position and the syringe holding member is in the needle pulling position, the syringe holding member is in a locked state with respect to the outer cylinder.
When the needle guard is in the pushing position and the syringe holding member is in the needle pulling position, the syringe holding member is in an unlocked state with respect to the outer cylinder.
After the needle guard moves from the initial position to the pushing position, the syringe holding member moves from the needle pulling position to the needle piercing position, and then the syringe holding member returns to the needle pulling position, and the needle guard moves. When returning to the initial position, the needle guard is locked with respect to the syringe holding member.
Adapter for syringe.

[Item 2]
The syringe holding member has a first engaging structure urged on the inner side surface side of the outer cylinder in a state of being inserted into the second columnar space of the outer cylinder.
The outer cylinder has a second engaging structure that engages with the first engaging structure of the syringe holding member when the syringe holding member is in the needle removal position.
The syringe adapter according to item 1.

[Item 3]
The needle guard has a tubular portion including a portion of the outer cylinder that protrudes from the second tip opening when in the initial position, and a side surface portion connected to the tubular portion.
The side surface portion is located between the inner side surface of the outer cylinder and the syringe holding member in the second columnar space of the outer cylinder.
The syringe adapter according to item 2, wherein when the needle guard moves to the pushing position, the side surface portion pushes down the second engaging structure of the syringe holding member so as to be separated from the inner side surface.

[Item 4]
The needle guard has a guide groove provided on the side surface portion, and the needle guard has a guide groove.
The syringe holding member has a protrusion that is inserted into the guide groove and is elastically supported in the tangential direction.
The guide groove extends in the moving direction of the needle guard and includes a common groove portion having a front end and a rear end, respectively, an outward groove portion and a return groove portion.
The common groove portion, the outward route groove portion, and the front end of the return route groove portion are located on the cylindrical portion side, respectively.
The outward groove portion and the return groove portion are arranged in the circumferential direction on the side surface portion.
The front end of the outward groove portion and the return groove portion is connected to the rear end of the common groove portion.
The side surface portion is provided at the branch convex portion protruding toward the outward path groove portion and the rear end of the return path groove portion in the vicinity of the front end between the outward path groove portion and the return path groove portion, and is provided at the rear end of the syringe holding member. Item 3. The syringe adapter according to item 3, which has a third engagement structure that engages with a protrusion.

[Item 5]
When the needle guard is in the initial position and the syringe holding member is in the needle pulling position, the protrusion of the syringe holding member is located at the rear end of the outward groove portion of the guide groove.
As the needle guard is pushed into the outer cylinder, the protrusion moves relatively toward the front end side of the outward groove portion, and when the needle guard moves to the pushing position, the protrusion moves to the outward groove portion. Located at the front end of the
When the syringe holding member moves from the needle withdrawal position to the needle piercing position, the protrusion gets over the branch convex portion and moves to the rear end of the common groove portion.
When the syringe holding member returns from the needle puncture position to the needle removal position, the protrusion moves from the front end to the rear end of the front groove to the front end of the return groove portion.
The syringe adapter according to item 4, wherein when the needle guard returns to the initial position, the protrusion is located at the rear end of the outward groove portion and engages with the third engaging structure.

[Item 6]
The needle guard and the syringe holding member have two guide structures composed of the guide groove and the protrusion.
Item 5. The syringe adapter according to item 5, wherein the two guide structures are arranged symmetrically with respect to the axis of the second columnar space of the outer cylinder.

[Item 7]
The syringe has a needle shield that covers the needle and has a needle shield.
6. Adapter for syringe.

[Item 8]
The syringe adapter according to any one of items 1 to 7, further comprising a wireless tag containing information about the drug filled in the syringe.

[Item 9]
The syringe holding member has a fourth engaging structure and has a fourth engaging structure.
The syringe adapter according to item 1, wherein the outer cylinder has a fifth engaging structure provided on the outer surface.

[Item 10]
An exterior case having an adapter space to which the syringe adapter according to item 9 can be mounted, an adapter opening communicating with the adapter space, and a cover for opening and closing the adapter opening.
To the piston, the piston gear that drives the piston in the direction of the piston axis, the gearbox that supports the piston and the piston gear, and the syringe holding member of the syringe adapter that is connected to the gearbox and inserted into the adapter space. A syringe lock member having a sixth engaging structure that engages with the fourth engaging structure provided is included, and the syringe holding member is moved between the needle sticking position and the needle pulling position, and the needle is pulled out. A piston unit that advances the stopper with the piston, and
A drive unit that includes a needle extraction motor and at least one gear and drives the piston unit in the direction of the piston axis.
The injection motor that drives the piston gear and
A control unit that controls the drive unit and the injection motor,
With memory
With an alarm
A drug infusion device equipped with.

[Item 11]
In the piston unit, the piston is in an initial position where the sixth engaging structure can engage the fourth engaging structure of the syringe adapter without the piston coming into contact with the stopper of the syringe. And the release position where the engagement between the sixth engagement structure and the fourth engagement structure of the syringe adapter is released, and the injection which advances from the initial position and inserts the stopper into the inside of the syringe. The drug infusion device according to item 10, which can take a position.

[Item 12]
A cover open / close detector that detects the open / close of the cover that opens / closes the adapter opening, and
It is equipped with an adapter mounting detector that detects the insertion of the syringe adapter into the adapter space.
The control unit can operate in a standby mode capable of detecting the output of the cover open / close detector and / or the output of the adapter mounting detector, and an operation mode capable of operating the drug injection device. And
When the syringe adapter is attached while the control unit is operating in the standby mode, the control unit switches the standby mode to the operation mode based on the output of the cover open / close detector and / or the adapter attachment detector. The drug infusion device according to item 10 or 11.

[Item 13]
The syringe adapter further comprises a wireless tag containing information about the drug filled in the syringe.
The drug injection device further includes a drug information detector that reads out information stored in the wireless tag.
The drug injection according to any one of items 10 to 12, wherein the control unit causes the alarm to notify information about the drug filled in the syringe acquired by the drug information detector while operating in the operation mode. Device.

[Item 14]
The syringe has a needle shield that covers the needle.
The syringe adapter has a hole that engages with the needle shield, covers the second tip opening of the outer cylinder, and further has a cap that is detachably supported by the outer cylinder.
The drug injection device is
A cap detector that detects the detachment of the cap of the syringe adapter, and
An adapter lock member having a seventh engaging structure that engages with the fifth engaging structure of the mounted syringe adapter and urged to come into contact with the outer surface of the syringe adapter.
Equipped with
The control unit notifies the alarm to remove the cap of the syringe adapter based on the output of the adapter mounting detector, and when the cap attachment / detachment detector detects the removal of the cap, the notification is given. The drug infusion device according to item 12 or 13, which notifies the device to press the tip of the syringe adapter against the injection site.

[Item 15]
A needle guard push detector that detects that the needle guard of the syringe adapter is in the push position, and
The injection button provided on the outer case and
Further prepare
The needle guard push detector detects that the needle guard of the syringe adapter is in the push position, and detects that the needle guard is in the push position.
The drug injection device according to item 14, wherein the control unit causes the alarm to notify the alarm to press the injection button based on the detection result of the needle guard push detector.

[Item 16]
A needle piercing completion detector that detects that the piston unit is in the piercing position, and
A needle removal completion detector that detects that the piston unit is in the needle removal position, and
Further equipped with an encoder for detecting the rotation of the injection motor,
The control unit
Based on the signal obtained by pressing the injection button, the drive unit is driven to move the piston unit forward.
The drive unit is stopped based on the detection result of the needle sticking completion detector, and the driving unit is stopped.
The injection motor is driven, the piston is advanced, and the drug is injected.
The injection motor is stopped based on the detection result of the encoder, and the injection motor is stopped.
After a lapse of a predetermined time, the drive unit is driven to retract the piston unit.
The drive unit is stopped based on the detection result of the needle removal completion detector, and the needle removal completion detector is stopped.
The drug injecting device according to item 15, wherein the alarm is notified to move the drug injecting device away from the skin.

[Item 17]
The control unit
Based on the detection result of the needle guard push detector, the injection motor is driven and the piston is retracted.
The drug injection device according to item 16, wherein the injection motor is stopped based on the detection result of the encoder.

[Item 18]
The adapter lock member is located in the outer case and moves the adapter lock member so as to disengage the fifth engagement structure of the mounted syringe adapter and the seventh engagement structure of the adapter lock member. With the eject button,
A discharge button detector that detects the operation of the discharge button, and
Further equipped with an origin detector for detecting that the piston has retracted to the release position.
The control unit
Slide the eject button to notify the syringe adapter to be pulled out.
Based on the detection result of the discharge button detector, the injection motor is driven to retract the piston.
The drug injection device according to item 17, wherein the injection motor is stopped based on the detection result of the origin detector.

[Item 19]
The control unit drives the injection motor based on the detection result of the cover open / close detector when the syringe adapter is removed and the cover is closed, and the piston is moved to the initial position based on the output of the encoder. Move it, stop the injection motor,
The drug injection device according to item 18, wherein the operation mode is switched to the standby mode.

[Item 20]
A drug injection system comprising the syringe adapter according to item 9 and the drug injection device according to item 10.

Hereinafter, an example of the syringe adapter, the drug injecting device, and the drug injecting system of the present embodiment will be described in detail with reference to the drawings. The drug injection system and the like described below are examples of embodiments. The embodiment is not limited to the following form, and various modifications can be made. In the drawings referred to in the following description, reference numerals may be omitted in the drawings not mentioned in the description for the sake of clarity.

(Configuration of drug injection system)
[Outline of drug injection system]
FIG. 1A is a perspective view showing the appearance of a drug injection system 300 including a syringe adapter 100 and a drug injection device 200, and FIG. 1B is a perspective view of the drug injection device 200 to which the syringe adapter 100 is attached. be. A syringe filled with a drug is stored in the syringe adapter 100.

The drug injection device 200 includes an outer case 201, and a main unit 202 is arranged in the outer case 201. Since the main unit 202 (see FIG. 12) is housed in the outer case 201, it is not shown in FIGS. 1A and 1B.

The outer case 201 has a tubular shape having a thickness that is easy for the operator to grasp with one hand, for example, and the cover 203 is provided on one end surface of the tubular shape. In the present embodiment, the outer case 201 has a tubular shape composed of two substantially flat planes and a curved surface connecting the two planes. However, the shape of the outer case 201 is not limited to this, and may have a cylindrical shape or a square cylinder shape. A skin contact surface 201b is provided on the end surface on which the cover 203 is provided.

When using the drug injection system 300, slide the cover 203, load the syringe adapter 100 from the adapter opening 201a (see FIG. 1B) provided at one end of the exterior case 201 in the longitudinal direction, and remove the cap 110. Allows the drug infusion system 300 to be ready for use.

At this time, as shown in FIG. 1B, the injection needle 12 of the syringe held in the syringe adapter 100 is covered with the needle guard 130, and the operator accidentally pierces the needle into a finger or the like. (See FIGS. 2 and 3). The needle guard 130 retracts when in use, allowing the needle of the injection needle 12 to be pierced. Further, after the injection of the drug is completed and the needle is removed, the injection needle is covered again, and the needle guard 130 cannot be retracted again. Thereby, the operator can remove the syringe adapter 100 without touching the injection needle 12 without paying special attention. In the present specification, the movement of the components of the syringe adapter 100 and the drug injection device 200 in the direction F in which the injection needle is inserted into the injection portion is referred to as forward movement, and the components move in the direction B in which the injection needle is pulled out. Doing is called retreat.

The exterior case 201 is provided with an adapter window 201c, a display window 201d, and a discharge button opening 201e. The syringe adapter 100 loaded can be confirmed from the adapter window 201c. A discharge button 204 is arranged in the discharge button opening 201e, and the syringe adapter 100 can be discharged from the drug injection device 200 by sliding the discharge button 204 after injecting the drug. A display device 255 provided in the main unit 202 is arranged in the display window 201d, and an operation procedure of the drug injection device 200, drug information of the loaded syringe adapter 100, and the like are displayed. The outer case 201 is provided with an injection button 254. Hereinafter, the structures of the syringe adapter 100 and the drug injection device 200 will be described in detail.

[Structure of Syringe 10 and Syringe Adapter 100]
<Syringe 10>
FIG. 2 is an exploded perspective view of the syringe adapter 100 containing the syringe 10, and FIG. 3 is an exploded perspective view of the syringe 10. The syringe 10 includes a barrel 11, an injection needle 12, a stopper 13 and a needle shield 14. The barrel 11 has a columnar space, and the columnar space is filled with a drug. The columnar space in the barrel 11 is sealed with a stopper 13. The tip of the barrel 11 is provided with a hole communicating with the columnar space, and the injection needle 12 is attached to the tip of the hole. A flange 11b is provided at the rear end of the barrel 11. The stopper 13 can move in the columnar space of the barrel 11 along the axis of the columnar shape, and when the piston 211 of the drug injection device 200 described later pushes the stopper 13, the drug is discharged from the tip of the injection needle 12. To. The stopper 13 may be provided with, for example, a screw hole 13a (FIG. 5B) for using another form of the drug injection device 200 or for attaching a piston for the operator to manually inject.

The needle 12 of the syringe 10 is covered with a needle shield 14 to protect the needle 12, maintain sterility, and prevent the operator from accidentally sticking the needle 12. An engaging portion 14a is provided on the outer surface of the needle shield 14. The engaging portion 14a has, for example, an uneven shape provided on the outer surface of the needle shield 14. The needle shield 14 is inserted into the hole of the cap 110 of the syringe adapter 100 described later, and is integrally removed from the syringe 10 together with the cap 110. The engaging portion 14a frictionally engages the needle shield 14 with the cap 110 so that the needle shield 14 is removed together with the cap 110 at the time of this removal. The engaging portion 14a is not limited to the shape shown in FIG. 3, and may have other forms. Further, the engaging portion 14a may be a rough surface that comes into contact with the inner surface of the hole of the cap 110 with a large friction. Alternatively, the needle shield 14 does not have an engaging portion 14a and has an outer shape slightly larger than the hole of the cap 110, and the needle shield 14 is frictionally welded by being press-fitted into the hole of the cap 110. May be.

The type of the drug to be filled in the syringe 10 may be one or a plurality. Further, the variation in the amount of the drug may be one or a plurality. That is, even if the syringe 10 has the same shape, the type and amount of the filled drug may be different.

<Adapter for syringe 100>
The syringe adapter 100 has a tubular shape and includes a cap 110, an outer cylinder 120, a needle guard 130, a needle guard spring 140, and a syringe holding member 180. The outer cylinder 120, the needle guard 130, and the syringe holding member 180 are made of, for example, resin. 4A, 4B and 4C are perspective views of the outer cylinder 120, the needle guard 130 and the syringe holding member 180. FIG. 5A is a perspective view of the syringe adapter 100 containing the syringe 10, and the outer cylinder 120 is shown by a broken line. 5B and 5C are cross-sectional views and side views of the syringe adapter 100. As shown in FIG. 5A, the direction parallel to the tubular axis a of the syringe adapter 100 is referred to as the axial direction A. Further, in the cross section perpendicular to the axis a, the radial direction R about the axis a is defined. Further, the tangential direction T of the circle centered on the axis a in the cross section is defined. These directions are similarly referred to with reference to the axes of the outer cylinder 120, the needle guard 130, the needle guard spring 140, and the syringe holding member 180.

The outer cylinder 120 of the syringe adapter 100 has a tubular shape. In this embodiment, the tubular shape is composed of two planes and a partial cylindrical side surface connecting the planes. By having this shape, the syringe adapter 100 does not easily roll on an equal flat surface of a desk. Further, when the operator attaches the drug injection device 200 to the drug injection device 200, it becomes easy to specify the attachment angle (correct rotation angle around the axis of the tubular shape) of the syringe adapter 100. For example, if the insertion angle of the syringe adapter 100 is adjusted so that the two planes of the cylinder shape of the outer cylinder 120 are parallel to the two planes of the outer case 201 of the drug injection device 200, the syringe adapter 100 can be obtained. It is possible to correctly load the drug injection device 200.

The syringe holding member 180 (see FIG. 4C) holds the syringe 10. In the present embodiment, the syringe holding member 180 has two flat surface portions 180p, 180q, and curved surface portions 180r, 180s connecting the two flat surfaces, corresponding to the side surface shape of the outer cylinder 120.

The syringe holding member 180 has a first insertion slot 180b and a first tip opening 180a, and a columnar space 180c located between the first insertion slot 180b and the first tip opening 180a. Mainly the barrel 11 portion of the syringe 10 is housed in the columnar space 180c of the syringe holding member 180, and at least a part of the injection needle 12 protrudes from the first tip opening 180a. The end portion 180h of the syringe holding member 180 that comes into contact with the flange 11b of the syringe 10 is located around the first insertion port 180b.

The syringe holding member 180 includes a lock mechanism 181 for fixing the syringe holding member 180 to the outer cylinder 120. In the present embodiment, the syringe holding member 180 includes two locking mechanisms 181 provided on the curved surface portions 180r and 180s, respectively. Each locking mechanism 181 includes a first engaging structure 181a, a contact surface 181b, an elastic portion 181c, and a second engaging structure 182a. The elastic portion 181c has one end connected to the curved surface portion 180r or 180s and the other end connected to the first engaging structure 181a, and the first engaging structure 181a is connected to the first engaging structure 181a in the radial direction with respect to the axis of the syringe holding member 180. Encourage the outside. Therefore, with the syringe holding member 180 inserted into the outer cylinder 120, the elastic portion 181c urges the first engaging structure 181a to the inner side surface side of the outer cylinder 120. In this embodiment, two contact surfaces 181b are arranged with respect to the first engaging structure 181a so as to sandwich the first engaging structure 181a in the circumferential direction of the curved surface portion 180r and 180s. As will be described later, the holding portion 130j of the needle guard 130 overlaps the contact surface 181b against the urging of the elastic portion 181c, so that the first engaging structure 181a moves toward the center side in the radial direction.

The first engaging structure 181a and the second engaging structure 182a have a shape that allows them to engage with each other, and the second engaging structure 182a is provided on the outer cylinder 120 as described later. The first engaging structure 181a and the second engaging structure 182a are detachably engaged with each other in the radial direction, and in the engaged state, they are engaged in the axial direction and disengaged, that is, disengaged from each other. Is impossible.

For example, the first engaging structure 181a and the second engaging structure 182a are a convex portion, a claw, or the like, and a concave portion, a hole, an opening, or the like into which the convex portion can be inserted. When the first engaging structure 181a is a convex portion, a claw, or the like, the second engaging structure 182a is a concave portion, a hole, an opening, or the like. When the second engaging structure 182a is a convex portion, a claw, or the like, the first engaging structure 181a is a concave portion, a hole, an opening, or the like. In the present embodiment, the first engaging structure 181a is a claw and the second engaging structure 182a is an opening.

In the present specification, the engaging structure is a convex portion, a claw, etc., and a concave portion, a hole, an opening, etc. into which the convex portion, the claw, etc. can be inserted, and the functions thereof are also described above, unless otherwise specified. It's a street. A combination of a convex portion and a convex portion, a convex portion and a claw, a claw and a claw, and the like may also form a set of engaging structures. A claw is a form of a convex portion, and refers to a convex portion in which one of two surfaces located in a moving direction such as a claw or a concave portion engaged with the claw has a gentler inclination than the other. If one of the set of engagement structures is a claw, the set of engagements is made by moving one or both of the set of engagement structures in the axial direction so that the gently sloping surfaces of the claws abut. Structures can be engaged. In the engaged state, if the engaging structure is further moved in the same direction, the engagement can be disengaged, but it is difficult to move the engaging structure in the opposite direction to disengage it.

The syringe holding member 180 is located on the side surface and includes a protrusion 180d elastically supported so as to be movable in the tangential direction. In this embodiment, two protrusions 180d are provided on the curved surface portions 180r and 180s, respectively. Each protrusion 180d is connected to one end of a rod-shaped elastic portion 180e extending in the axial direction, and the other end of the elastic portion 180e is connected to a curved surface portion 180r or 180s. By bending the elastic portion 180e, the protrusion 180d can move in the tangential direction T. By bending the elastic portion 180e from the neutral position, the protrusion 180d is urged by the elastic portion 180e in a direction of moving to the neutral position according to the displacement from the neutral position.

The syringe holding member 180 includes a fourth engaging structure 180f in the vicinity of the first insertion port 180b of the flat surface portions 180p and 180q. The fourth engaging structure 180f engages with the sixth engaging structure 221a provided on the syringe lock member 221 of the piston unit 210 described later. For example, in this embodiment, the fourth engaging structure 180f is an opening.

The needle guard 130 (see FIG. 4B) is composed of a tubular portion 130A and two side surface portions 130B, and has a second columnar space 130c into which the syringe holding member 180 is inserted. The tubular portion 130A includes flat surface portions 130p and 130q and curved surface portions 130r and 130s connected to the flat surface portions 130p and 130q. A third tip opening 130a is provided at one end of the tubular portion 130A, and a contact portion 130h is arranged around the third tip opening 130a.

The side surface portion 130B is connected to the other end of the tubular portion 130A and extends in the axial direction. Two openings 130C are formed between the two side surface portions 130B. The insertion port 130b is located at the end of the side surface portion 130B located on the opposite side of the tubular portion 130A.

The needle guard 130 has a guide groove 131 provided on each side surface portion 130B. The guide groove 131 includes a common groove portion 131A extending in the axial direction A, an outward route groove portion 131B, and a return route groove portion 131C, respectively. The front ends 131Aa, 131Ba, 131Ca of the common groove portion 131A, the outward groove portion 131B, and the return path groove portion 131C are located on the cylindrical portion 130A side, respectively. The outward groove portion 131B and the return path groove portion 131C are arranged in the circumferential direction on the side surface portion 130B. The front end 131Ba of the outward groove 131B and the front end 131Ca of the return groove 131C are connected to the rear end 131Ab of the common groove 131A.

The side surface portion 130B has a branch convex portion 131D protruding toward the outward path groove portion 131B in the vicinity of the front ends 131Ba and 131Ca between the outward path groove portion 131B and the return path groove portion 131C, and is provided at the rear end 131Cb of the return path groove portion 131C. It has an engaging structure 131E. The third engaging structure 131E can be engaged with the protrusion 180d, and in the present embodiment, the third engaging structure 131E is a claw. The guide grooves 131 provided on the two side surface portions 130B are preferably arranged symmetrically with respect to the axis a (see FIG. 5C).

The protrusion 180d of the syringe holding member 180 is inserted into the guide groove 131. By pushing the needle guard 130 and moving the syringe holding member 180 by the needle piercing operation of the syringe 10, the protrusion 180d of the syringe holding member 180 moves relatively in the guide groove 131 of the needle guard 130. As will be described later, in the initial position, the protrusion 180d is located at the rear end 131Bb of the outward groove portion 131B, but when the needle guard 130 is pushed in and the needle of the injection needle 12 is pierced, the protrusion 180d becomes the front end of the common groove portion 131A. When the needle guard 130 moves to 131Aa and returns to its original position after the needle is removed, the protrusion 180d is guided to the return groove portion 131C and reaches the rear end 131Cb. At this time, the protrusion 180d is locked by the third engaging structure 131E.

As described above, since the guide grooves 131 arranged on the two side surface portions 130B are arranged symmetrically with respect to the axis a, when the two protrusions 180d move relatively in the corresponding guide grooves 131. , The stress due to the deformation of each elastic portion 180e is generated symmetrically with respect to the axis a. Therefore, when the needle guard 130 moves with respect to the syringe holding member 180, the axis of the needle guard 130 and the axis of the syringe holding member 180 are suppressed from being shaken, and the needle guard 130 can move smoothly. Become.

A slit 130g extending along the axial direction A is provided on the insertion port 130b side of the side surface portion 130B with respect to the guide groove 131, and the side surface portion 130B is divided into two pressing portions 130j by the slit 130g.

The needle guard 130 has a protrusion 130k on the tubular portion 130A side of the guide groove 131 of the side surface portion 130B.

As shown in FIGS. 5A, 5B, and 5C, a part of the syringe holding member 180 is inserted into the third columnar space 130c of the needle guard 130. The flat surface portions 180p and 180q of the syringe holding member 180 are located at the two openings 130C of the needle guard 130. Further, the two pressing portions 130j of the side surface portion 130B overlap with the curved surface portions 180r and 180s of the syringe holding member 180 so that the elastic portion 181c of the lock mechanism 181 and the first engaging structure 181a can be inserted into the slit 130g. In addition, the needle guard 130 is movable relative to the syringe holding member 180 in the axial direction. Further, a protrusion 180d of the syringe holding member 180 is inserted in the guide groove 131 of the needle guard 130.

The needle guard spring 140 is inserted into the tubular portion 130A of the needle guard 130, and one end thereof is in contact with the contact portion 130h. The other end of the needle guard spring 140 comes into contact with the outer cylinder 120.

The outer cylinder 120 (see FIG. 4A) has a tubular shape, and has a second insertion port 120b and a second tip opening 120a, and a second columnar space 120c into which a syringe holding member 180, a needle guard spring 140, and a needle guard 130 are inserted. It has the specified aspects. As described above, the side surface of the outer cylinder 120 is composed of flat surface portions 120p and 120q and curved surface portions 120r and 120s connecting them.

Slits 120e are provided on the side of the second tip opening 120a of the curved surface portions 120r and 120s, respectively. A protrusion 130k of the needle guard 130 is inserted into the slit 120e (see FIG. 5A). A fifth engagement structure 120f is provided on the outer surface of the curved surface portions 120r and 120s on the second insertion port 120b side, respectively. The fifth engaging structure 120f is a concave portion, an opening, a convex portion or the like that can be engaged with the seventh engaging structure 241a of the adapter lock member 241. In the present embodiment, for example, an opening penetrating the curved surface portions 120r and 120s. Is. The fifth engaging structure 120f has a slope 120t on the side of the second tip opening 120a in the axial direction A.

A second engaging structure 182a is provided on the curved surface portions 120r and 120s. In the present embodiment, the second engaging structure 182a is an opening penetrating the curved surface portions 120r and 120s, but the second engaging structure 182a may be a recess provided on the inner surface of the curved surface portions 120r and 120s. good.

An opening 120g is provided on the side of the second insertion port 120b of the flat surface portions 120p and 120q. The fourth engaging structure 180f of the syringe holding member 180 is exposed from the opening 120 g (see FIG. 5A). Further, a contact surface 120j is provided inside the outer cylinder 120 in the vicinity of the second tip opening 120a. The other end of the needle guard spring 140 comes into contact with the contact surface 120j (see FIG. 4A).

A recess 120k is provided in the flat surface portion 120p of the outer cylinder 120, and a wireless tag 190 (see FIG. 2) is provided in the recess 120k. The radio tag 190 is also called RFID (Radio Frequency Identification), and can transmit and receive information by short-range communication using radio waves in the UHF and HF bands, for example. The wireless tag 190 includes, for example, a memory in which information regarding the type of the drug and the amount of the drug filled in the syringe 10 is stored. Although not shown in the figure, in the syringe 10 built in the syringe adapter 100, in place of the wireless tag 190, or in addition to the wireless tag 190, with or without the shape feature provided in the outer cylinder 120. Information regarding the type of the encapsulated drug 15 and the amount of the drug may be represented.

The cap 110 includes a cap body 111 and a cap claw 112. The cap body 111 is provided with a hole 111d into which the needle shield 14 of the syringe 10 can be inserted. An engaging portion that engages with the engaging portion 14a of the needle shield 14 is provided on the inner surface that defines the hole 111d. Further, a cap claw 112 is arranged at the bottom of the hole 111d (see FIG. 2).

In the syringe adapter 100, the syringe holding member 180 holding the syringe 10 is inserted into the second columnar space 120c of the outer cylinder 120 and is movably supported in the second columnar space 120c in the axial direction A.

The needle guard 130 is inserted into the second columnar space 120c of the outer cylinder 120 so that the side surface portion 130B is located between the outer cylinder 120 and the syringe holding member 180, and a part of the tubular portion 130A is the outer cylinder 120. It is supported so as to be movable in the axial direction so as to be able to project from the second tip opening 120a of the above.

[Operation of adapter 100 for syringe]
Next, the operation of the syringe adapter 100 will be described. In a general usage mode, after the syringe adapter 100 is attached to the drug injection device 200, the cap 110 is removed, the needle guard 130 is retracted, and the like. However, for the sake of clarity, the operation of the syringe adapter 100 will be described in a state of being separated from the drug injection device 200.

The syringe holding member 180 moves between the needle insertion position where at least a part of the injection needle 12 protrudes from the second tip opening 120a of the outer cylinder 120 and the needle extraction position where the injection needle 12 does not protrude from the second tip opening 120a. It is possible. Further, the needle guard 130 can move between an initial position in which a part of the needle guard 130 protrudes from the second tip opening 120a and a pushing position in which the needle guard 130 does not protrude from the second tip opening 120a. Depending on the position of these members, the syringe holding member 180 can be fixed to the outer cylinder 120, and the injection needle 12 can be protected by the needle guard 130. Hereinafter, the structure and operation of the syringe adapter 100 in each state will be described with reference to FIGS. 5A, 5B, 5C to 11A, 11B, 11C. 5A to 11A are perspective views of the syringe adapter 100, and the outer cylinder 120 is shown by a broken line. 5B to 11B are cross-sectional views of the syringe adapter 100, and FIGS. 5C to 11C are side views of the syringe adapter 100.

(1) Initial State As shown in FIGS. 5A to 5C, the cap 110 covers the second tip opening 120a of the outer cylinder 120 before and immediately after loading the syringe adapter 100 into the drug injection device. .. Since the injection needle 12 is located in the outer cylinder 120 and does not protrude from the second tip opening 120a, the syringe holding member 180 is in the needle extraction position in the outer cylinder 120. The needle guard 130 is urged by the needle guard spring 140 in a projecting direction so that a part of the tubular portion 130A protrudes from the second tip opening 120a of the outer cylinder 120 and is in the initial position. The protruding portion of the tubular portion 130A is covered with a cap 110. The protrusion 180d of the syringe holding member 180 is located at the rear end 131Bb of the outward groove portion 131B of the needle guard 130. Further, the protrusion 130k of the needle guard 130 is inserted into the slit 120e of the outer cylinder 120.

As a result, the syringe holding member 180 is locked with respect to the outer cylinder 120 and cannot move in the axial direction A. The fourth engaging structure 180f of the syringe holding member 180 is located within the opening 120g of the outer cylinder 120, and can be engaged with the sixth engaging structure 221a of the syringe lock member 221 of the drug injection device as described later. Yes (see Figure 20A).

(2) Removal of the cap 110 When the cap 110 is removed from the outer cylinder 120 from the state shown in FIGS. 5A to 5C, the inner surface of the hole 111d of the cap 110 is engaged with the engaging portion 14a of the needle shield 14. , The needle shield 14 is also removed together with the cap 110. At this time, since the syringe holding member 180 is in a locked state with respect to the outer cylinder 120, the syringe 10 into which the needle shield 14 is inserted is not pulled out or moved together with the needle shield 14.

As shown in FIGS. 6A to 6C, by removing the cap 110, a part of the tubular portion 130A of the needle guard 130 protrudes from the second tip opening 120a of the outer cylinder 120 due to the urging of the needle guard spring 140. It is in a state and is in the initial position. In this state, since the needle guard 130 is not locked to the outer cylinder 120 and the syringe holding member 180, it can move in the axial direction A with respect to the outer cylinder 120. However, since the protrusion 180d of the syringe holding member 180 locked to the outer cylinder 120 is located at the rear end 131Bb of the outward groove portion 131B of the needle guard 130, the direction in which the needle guard 130 further protrudes from the second tip opening 120a. It cannot move to, but can move only in the direction in which the needle guard 130 is pushed.

(3) Pressing against the injection site Press the tip of the needle guard 130 against the injection site to enable needle sticking. When the needle guard 130 is pressed against the injection site, as shown in FIGS. 7A to 7C, the needle guard 130 is outside to the pushing position where the entire needle guard 130 is housed inside the outer cylinder 120 while compressing the needle guard spring 140. Retreat with respect to the cylinder 120. At this time, the holding portion 130j of the side surface portion 130B located between the outer cylinder 120 and the syringe holding member 180 abuts on the contact surface 181b of the lock mechanism 181 while retracting, and the first engagement of the lock mechanism 181 is performed. The structure 181a is pushed down so as to be separated from the inner side surface of the outer cylinder 120. As a result, the first engaging structure 181a is separated from the second engaging structure 182a of the outer cylinder 120. Further, as the guide groove 131 moves, the protrusion 180d relatively moves to the front end 131Ba side of the outward groove portion 131B.

As a result, the syringe holding member 180 is in an unlocked state in which the outer cylinder 120 is unlocked. That is, the syringe holding member 180 can move in the axial direction A with respect to the outer cylinder 120.

(4) Needle piercing As described later, the piercing operation causes the syringe holding member 180 to move forward and at least a part of the injection needle 12 to protrude from the second tip opening 120a, as shown in FIGS. 8A to 8C. It moves to the needle stick position with respect to the outer cylinder 120 and the needle guard 130.

At this time, with the movement of the syringe holding member 180, the protrusion 180d moves from the front end 131Ba of the outward groove portion 131B over the branch convex portion 131D to the common groove portion 131A and reaches the front end 131Aa of the common groove portion 131A. Even if the syringe holding member 180 moves, the fourth engaging structure 180f is located within the opening 120g of the outer cylinder 120. Therefore, the engagement between the sixth engagement structure 221a and the fourth engagement structure 180f of the syringe lock member 221 of the drug injection device 200 can be maintained (see FIG. 23A).

(5) Drug injection By performing the drug injection operation as described later, the stopper 13 is pushed into the barrel 11 as shown in FIGS. 9A to 9C, and the drug is injected from the injection needle 12 into the injection site. .. At this time, since the outer cylinder 120, the needle guard 130, and the syringe holding member 180 do not move, the needle guard 130 is in the pushing position and the syringe holding member 180 is in the needle piercing position.

(6) Needle removal As described later, the needle removal operation causes the syringe holding member 180 to retract with respect to the outer cylinder 120 to the needle removal position, as shown in FIGS. 10A to 10C. The injection needle 12 does not protrude from the second tip opening 120a and is located inside the outer cylinder 120. At this time, as the syringe holding member 180 moves, the protrusion 180d is guided from the common groove portion 131A to the branch convex portion 131D and moves to the front end 131Ca of the return groove portion 131C.

When the syringe holding member 180 returns to the needle pulling position, the first engaging structure 181a of the lock mechanism 181 is in a position facing the second engaging structure 182a. However, since the pressing portion 130j is in contact with the contact surface 181b, the first engaging structure 181a remains separated from the second engaging structure 182a, and the syringe holding member 180 is in an unlocked state.

(7) Separation from the injection site When the syringe adapter 100 is separated from the injection site, the needle guard 130 advances due to the elastic force of the needle guard spring 140, and as shown in FIGS. 11A to 11C, the second tip It returns to the initial position where a part of the tubular portion 130A of the needle guard 130 protrudes from the opening 120a.

Along with this, the holding portion 130j of the side surface portion 130B advances and separates from the contact surface 181b of the lock mechanism 181. Since the force against the urging of the elastic portion 181c does not work, the first engaging structure 181a of the lock mechanism 181 of the syringe holding member 180 is urged to the inner side surface side of the outer cylinder 120 by the elastic portion 181c, and the first The engagement structure 181a engages with the second engagement structure 182a of the outer cylinder 120. That is, the syringe holding member 180 is locked with respect to the outer cylinder 120. In this state, the syringe adapter 100 is removed from the drug injection device.

Further, as the guide groove 131 moves with the movement of the needle guard 130, the protrusion 180d relatively moves to the rear end 131Cb of the return groove portion 131C. At this time, since the protrusion 180d that has reached the rear end 131Cb engages with the third engagement structure 131E because it gets over the third engagement structure 131E and moves to the rear end 131Cb, it cannot move to the front end side 131Ca. That is, the protrusion 180d cannot move at the rear end 131Cb of the return groove portion 131C, and the needle guard 130 is fixed to the syringe holding member 180. As a result, the syringe holding member 180 and the needle guard 130 are directly or indirectly locked to the outer cylinder 120, making it difficult to move.

In the syringe adapter 100 in this state, the needle guard 130 is in the initial position and the syringe holding member 180 is in the needle removal position, which is the same as the initial state. However, by fixing the protrusion 180d in the guide groove 131 to the rear end 131Cb of the return groove portion 131C as described above, the retreat of the needle guard 130 is suppressed. Therefore, even if the operator intentionally tries to retract the needle guard 130, the needle guard 130 does not retract. Therefore, the operator cannot easily come into contact with the injection needle 12, and can prevent the operator from accidentally sticking the injection needle 12 into the body, catching the injection needle 12 on clothes, and the like. ..

As described above, according to the syringe adapter 100, the syringe holding member 180 and the needle guard 130 can be moved according to the state at the time of use, and are locked except when necessary to suppress the movement. Therefore, the operator can handle the syringe adapter 100 without paying special attention to accidentally sticking a finger with an injection needle or catching it on clothes or the like.

[Structure of drug injection device 200]
<Outline of the configuration of the drug injection device 200>
The drug injection device 200 includes a main unit 202 housed in the outer case 201. FIG. 12 is a perspective view of the main unit 202 into which the syringe adapter 100 is inserted. FIG. 13 is a block diagram showing a schematic circuit configuration of the drug injection system 300. The main unit 202 has an adapter space 202a to which the syringe adapter 100 can be mounted. In a state where the main unit 202 is housed in the outer case 201, the adapter space 202a is the adapter opening 201a of the outer case 201 (FIG. Refer to 1B). The main unit 202 includes the housing 205 and supports the components described below.

The main unit 202 includes a control unit 251 including an arithmetic unit such as a CPU, a battery 252 as a power source, a memory 253 for storing computer programs, data, and the like, an injection button 254 as an interface, and a clock 257 ( See FIG. 13). The control unit 251 reads the program stored in the memory 253 and controls each component according to the procedure of the computer program. The procedure of the computer program is shown by the flow chart of the description and the attached drawing described later.

Further, although not shown in FIG. 12, the main unit 202 includes an alarm 291, a drive device 293, and a detector 295. The alarm 291 includes, for example, a display device 255 and a buzzer 256 to provide the operator with information regarding the operation of the drug injection device 200 (see FIG. 13).

The drive device 293 advances and retracts the syringe holding member 180 in the loaded syringe adapter 100 to pierce and remove the injection needle 12 of the syringe 10. Further, the stopper 13 is pushed by the piston to inject the drug. The drive device 293 includes a piston unit 210, a drive unit 230 for driving the piston unit, an injection motor 261 and an encoder 262. The piston unit 210 further includes a needle extraction motor 264. The injection motor 261 and the needle extraction motor 264 are driven by motor drivers 260 and 263, respectively (see FIG. 13).

The detector 295 includes an encoder 262, a cover open / close detector 271, an adapter mounting detector 272, a drug information detector 273, a cap detector 274, a needle guard push detector 275, a needle sticking completion detector 276, and a needle removal completion detector 277. , Includes a piston origin detector 278 and a discharge button detector 279 (see FIG. 13). These detect the state of each part of the drug injection device 200 and acquire the information of the wireless tag 190 provided in the syringe adapter 100. These components will be described in detail below.

The drug injection device 200 may also include a communication device 292. The communication device 292 includes, for example, an infrared communication device 258 and a wireless communication device 259, and transmits / receives information to / from the outside. Specifically, a supervisor such as a doctor who prescribes a drug sends information about an operator who uses the drug injection device 200, for example, information such as a drug injection amount, a drug type, and an injection time. Can be transmitted to the drug injecting device 200 using. The transmitted information is stored in, for example, the memory 253 and is used when the drug injection device 200 is used. Further, the wireless communication device 259 is, for example, a transmitter / receiver that uses a short-range wireless communication standard. For example, the time when the operator used the drug injection device 200, the type of drug, the injection amount, etc. are stored in the memory 253 at the time of use, and these information are stored in an external device using the wireless communication device 259 at a predetermined timing. May be sent to.

<Structure of drive device 293>
14A and 14B are perspective views of the drive device 293. As described above, the drive device 293 moves the syringe holding member 180 containing the syringe 10 between the needle insertion position and the needle removal position in the syringe adapter 100 loaded in the drug injection device 200, and also. Using the piston 211 described later, the stopper 13 of the syringe 10 is inserted into the barrel 11. For this purpose, the drive device 293 includes a piston unit 210, a drive unit 230 for driving the piston unit 210 in the piston axial direction, and an injection motor 261.

The piston unit 210 includes a piston 211, a piston gear 212 that drives the piston 211 in the piston axial direction, and a gearbox 214 that supports the piston 211 and the piston gear 212. 15A and 15B are perspective views of the drive unit 293 excluding the gearbox 214 and the drive unit 230. The piston 211 is formed on the front end portion 211a that comes into contact with the stopper 13 of the syringe 10, the convex portion 211b that is adjacent to the tip portion 211a and protrudes in the radial direction, and the side surface from the end of the convex portion 211b to the other end of the piston 211. It is provided with a male screw 211c. The piston gear 212 has a tubular shape, and a female screw 212c that meshes with the male screw 211c of the piston 211 is provided on the inner surface of the cylinder. Further, a spur gear 212b having a large tooth width L is provided on the side surface of the piston gear 212. The piston gear 212 is attached to the gearbox 214, for example, via a bearing 216 (see FIGS. 15A, 15B). The piston 211 is inserted into the piston gear 212 in a state where the male screw 211c and the female screw 212c are in mesh with each other. Therefore, the gearbox 214 supports the piston 211 and the piston gear 212, and when the piston gear 212 moves in the axial direction of the piston, the piston 211 and the piston gear 212 also move integrally. The gearbox 214 has an arm 214a, and the arm 214a is provided with a female screw 214b (see FIG. 14B).

The drive device 293 further includes, for example, a motor gear 245 and an intermediate gear 246, and a motor gear 245 is attached to the shaft of the injection motor 261. The intermediate gear 246 meshes with the spur gear 212b of the motor gear 245 and the piston gear 212. When the injection motor 261 rotates, the piston gear 212 rotates, and as shown in FIG. 15B, the piston 211 advances due to the engagement between the male screw 211c and the female screw 212c. Since the tooth width L is determined to be longer than the distance between the needle insertion position and the needle extraction position of the syringe holding member 180, even if the piston unit 210 moves for needle insertion and needle extraction, the intermediate gear 246 is a piston. The state of meshing with the spur gear 212b of the gear 212 can be maintained. In order to prevent the piston 211 from rotating together with the piston gear 212, the male screw 211c may be provided with a notch extending in the axial direction, and the gearbox 214 may be provided with a convex portion that engages with the notch.

The drive unit 230 includes a needle extraction motor 264, a motor gear 231, an intermediate gear 232, and a drive screw 233. The motor gear 231 is attached to the rotating shaft of the needle extraction motor 264. The drive screw 233 has a shaft parallel to the shaft of the piston 211, and a male screw 233b is provided on the side surface thereof. The male screw 233b meshes with the female screw 214b provided on the arm 214a of the gearbox 214. A spur gear 233a is provided at one end of the drive screw 233. The intermediate gear 232 meshes with the motor gear 231 and the spur gear 233a (see FIGS. 14A and 14B).

When the needle extraction motor 264 rotates, the rotational force is transmitted to the drive screw 233, and the drive screw 233 rotates. As a result, as shown in FIG. 14B, the gearbox 214 having the female screw 214b meshed with the male screw 233b of the drive screw 233 moves along the axial direction of the piston 211. The entire piston unit 210 including the gearbox 214 moves forward or backward depending on the rotation direction of the needle pulling motor 264.

When the piston unit 210 performs an operation of injecting a drug, the piston 211 advances by the above-mentioned operation, the tip portion 211a thereof abuts on the stopper 13, the stopper 13 is pushed into the barrel 11 of the syringe 10, and the drug is injected. Will be done. At this time, it is preferable that the syringe holding member 180 is appropriately fixed so that the entire syringe 10 including the barrel 11 does not move forward. To this end, the piston unit 210 includes a support structure 220 that supports the syringe holding member 180. The support structure 220 includes a syringe lock member 221, a support member 222, and a urging spring 223 (see FIGS. 14A and 14B). 16A and 16B are perspective views showing the structure and operation of the syringe lock member 221. The syringe lock member 221 has a shape extending along the piston 211, and one end thereof is connected to the gearbox 214. The other end has a sixth engaging structure 221a. The piston unit 210 has two syringe lock members 221 and the two syringe lock members 221 are arranged with the piston 211 interposed therebetween so that the sixth engagement structure 221a faces each other. The syringe lock member 221 has an abutting portion 221b protruding toward the piston 211 between both ends. The syringe lock member 221 is made of an elastic member such as a leaf spring.

The support member 222 has a contact surface 222a and a through hole, and is movably supported along the piston 211 by inserting the piston 211 into the through hole. An urging spring 223 is arranged between the support member 222 and the gearbox 214, and the support member 222 is urged toward the tip portion 211a of the piston 211 and is in contact with the convex portion 211b of the piston 211.

As shown in FIG. 17A, when the syringe adapter 100 is inserted into the drug injection device 200, the sixth engaging structure 221a of the syringe lock member 221 is provided on the barrel 11 of the syringe 10 held by the syringe holding member 180. It gets over the flange 11b and engages with the fourth engagement structure 180f of the syringe holding member 180. Further, the contact surface 222a of the support member 222 comes into contact with the flange 11b. Therefore, the support structure 220 of the piston unit 210 can sandwich the flange 11b between the support member 222 and the sixth engagement structure 221a of the syringe lock member 221 to reliably support the syringe 10 and the syringe holding member 180. ..

As shown in FIG. 17B, when the needle pulling motor 264 rotates the drive screw 233 in this state, the piston unit 210 advances while the support structure 220 holds the syringe holding member 180, and performs the needle sticking operation. Can be done.

When the support structure 220 of the piston unit 210 releases the support of the syringe holding member 180, the injection motor 261 is reversed to retract the piston 211 further from the needle removal position, as shown in FIG. 16B. The contact portion 221b of the syringe lock member 221 abuts on the convex portion 211b of the piston 211 and rides on the convex portion 211b, whereby the sixth engaging structure 221a of the syringe lock member 221 moves in a direction away from the axis of the piston 211. do. As a result, the sixth engaging structure 221a is separated from the fourth engaging structure 180f, and the engagement is released. When the support structure 220 is in this state, the syringe adapter 100 can be pulled out.

<Lock mechanism of adapter 100 for syringe>
The drug injection device 200 includes an adapter lock mechanism 240 in order to prevent the syringe adapter 100 from being inadvertently dropped or pulled out during use. 18A and 18B are perspective views showing the adapter lock mechanism 240. The adapter lock mechanism 240 includes an adapter lock member 241, a discharge button 204, an urging spring 242, and a fifth engagement structure 120f. The adapter lock member 241 is supported by the main unit 202 or the outer case 201 so as to be movable in the axial direction A, and has a base portion 241c, an elastic portion 241b, and a seventh engaging structure 241a. The elastic portion 241b has a longitudinal direction along the axial direction A, and the seventh engaging structure 241a is located at one end thereof. The other end of the elastic portion 241b is connected to the base portion 241c. The base 241c is urged in the retracting direction by the urging spring 242.

When the syringe adapter 100 is inserted into the drug injection device 200, the seventh engagement structure 241a of the adapter lock member 241 engages with the fifth engagement structure 120f of the outer cylinder 120. Therefore, even if the syringe adapter 100 falls off due to gravity or the like due to the engagement between the fifth engagement structure 120f and the seventh engagement structure 241a, or if the syringe adapter 100 is to be pulled out, the syringe adapter 100 moves. Is suppressed.

When removing the syringe adapter 100, the discharge button 204 is slid against the urging of the urging spring 242 toward the adapter opening 201a, that is, in the forward direction. As a result, the adapter lock member 241 moves in the forward direction, the seventh engaging structure 241a comes into contact with the slope 120t of the fifth engaging structure 120f, and the tip of the seventh engaging structure 241a is attached to the exterior along the slope 120t. It is lifted to the inner surface side of the case 201. The tip of the seventh engaging structure 241a is inserted into and engaged with the recess 201f provided on the inner surface of the outer case 201 (see FIG. 18C). As a result, the engagement between the 7th engagement structure 241a and the 5th engagement structure 120f is released, and the syringe adapter 100 can be pulled out. In this state, the adapter lock member 241 is urged in the retracting direction by the urging spring 242. Therefore, when the operator releases the finger from the discharge button 204, the urging spring 242 retracts the adapter lock member 241. Again, the state in which the seventh engaging structure 241a and the fifth engaging structure 120f are engaged is returned.

As described above, according to the present embodiment, the syringe adapter 100 can be removed when the operator is in the state of operating the discharge button 204. Therefore, even if the operator unintentionally slides the discharge button 204, it is necessary to maintain the state in order to remove the syringe adapter 100. Therefore, the syringe adapter 100 must be removed by an unintended operation. Can be suppressed.

[Operation of drug injection device 200]
The operation of the drug injection device 200 will be described with reference to FIGS. 19A and 19B to 31A and 31B. In these figures, FIGS. 19A-31A show a vertical cross section of the drug injection device 200, and FIGS. 19B-31B show a horizontal cross section of the drug injection device 200.

(1) Initial state (Figs. 19A and 19B)
In the initial state, the piston unit 210 is in the needle pulling position and the piston 211 is in the initial position.

(2) Mounting of the syringe adapter 100 (FIGS. 20A and 20B)
The syringe adapter 100 is inserted through the adapter opening 201a of the drug injection device 200. The sixth engaging structure 221a of the support structure 220 of the piston unit 210 engages with the fourth engaging structure 180f provided on the syringe holding member of the syringe adapter 100. Further, the contact surface 222a of the support member 222 comes into contact with the flange 11b. Therefore, the support structure 220 of the piston unit 210 reliably supports the syringe 10 and the syringe holding member 180. On the other hand, when the seventh engaging structure 241a of the adapter locking member 241 engages with the fifth engaging structure 120f of the outer cylinder 120, the adapter locking mechanism 240 locks the adapter 100 for the syringe.

In the syringe adapter 100, the needle guard 130 is in the initial position and the syringe holding member 180 is in the needle removal position. Further, the syringe holding member 180 is locked to the outer cylinder 120 by the lock mechanism 181.

(3) Cap removal (Figs. 21A and 21B)
Remove the cap 110 from the syringe adapter 100. The needle guard 130 is in a state of protruding from the outer cylinder 120 and the adapter opening 201a of the drug injection device 200. As described above, the syringe holding member 180 is locked to the outer cylinder 120 by the locking mechanism 181 and the support structure 220 of the piston unit 210 supports the syringe 10 and the syringe holding member 180, so that the cap is used. When the 110 is removed, the syringe 10 and the syringe holding member 180 are prevented from being pulled out together.

(4) Press against the injection site (Figs. 22A and 22B)
When the needle guard 130 is pressed against the injection site, the needle guard 130 retracts and moves from the initial position to the pushing position. The needle guard 130 is housed in the outer cylinder 120 of the syringe adapter 100 loaded in the drug injection device 200, and the skin contact surface 201b of the outer case 201 comes into contact with the injection site. When the needle guard 130 moves to the pushing position, the lock mechanism 181 is released, and the syringe holding member 180 can move with respect to the outer cylinder 120 at the needle pulling position.

(5) Needle (Figs. 23A and 23B)
When the operator pushes down the injection button 254, the needle extraction motor 264 rotates forward and the piston unit 210 advances to the needle insertion position. As a result, the syringe holding member 180 of the syringe adapter 100 is removed from the needle removal position while the sixth engaging structure 221a of the support structure 220 of the piston unit 210 is engaged with the fourth engaging structure 180f of the syringe holding member 180. Moving to the needle puncture position, a part of the injection needle 12 protrudes from the adapter opening 201a of the drug injection device 200.

(6) Drug injection (Figs. 24A and 24B)
The injection motor 261 rotates in the normal direction, and the piston 211 moves from the initial position to the injection position. As a result, the stopper 13 is inserted into the barrel 11 and the drug is injected from the injection needle 12 into the injection site. The position where the stopper 13 stops depends on the amount of the drug held in the barrel 11 of the syringe 10 and the injection amount according to the operator.

(7) Needle removal (Figs. 25A and 25B)
After the injection of the internal medicine by the movement of the stopper 13 is completed, the needle pulling motor 264 reverses, the piston unit 210 retracts, and returns from the needle pulling position to the needle pulling position. As a result, the injection needle 12 is pulled out from the injection site.

(8) Separated from the injection site (FIGS. 26A and 26B)
When the operator separates the skin contact surface 201b of the outer case 201 from the injection site, the needle guard 130 advances by the urging of the needle guard spring 140 and protrudes from the adapter opening 201a. Along with this, the lock mechanism 181 locks the syringe holding member 180 with respect to the outer cylinder 120, and the lock mechanism 181 is in a state of not moving with respect to the outer cylinder 120. Further, the needle guard 130 is locked with respect to the syringe holding member 180.

(9) Piston retreat (Figs. 27A and 27B)
The injection motor 261 reverses and the piston 211 moves from the injection position to the initial position.

(10) Discharge button operation (FIGS. 28A and 28B)
When the operator slides the discharge button 204, the adapter lock mechanism 240 releases the outer cylinder 120 of the syringe adapter 100.

(11) Retreat of the piston (FIGS. 29A and 29B)
The injection motor 261 reverses, further retracts from the initial position, and moves to the release position. As a result, the sixth engaging structure 221a of the support structure 220 of the piston unit 210 is separated from the fourth engaging structure 180f provided on the syringe holding member 180 of the syringe adapter 100, and the support structure 220 holds the syringe holding member 180. It will be in the released state.

(12) Adapter removal (Figs. 30A and 30B)
Both the outer cylinder 120 and the syringe holding member 180 of the syringe adapter 100 are in the released state, the needle guard 130 is locked with respect to the syringe holding member 180, and the syringe holding member 180 is locked with respect to the outer cylinder 120. ing. When the operator pulls the needle guard 130 of the syringe adapter 100, the entire syringe adapter 100 moves, and the syringe adapter 100 is removed from the drug injection device 200.

(13) Return to the initial state (FIGS. 31A and 31B)
The injection motor 261 rotates in the normal direction, and the piston 211 advances from the released position and returns to the initial position. As a result, the operation of the drug injection device 200 is completed.

[Arrangement and operation of various detectors]
As described above, the drug injection device 200 of the present embodiment is provided with various detectors to provide an easy-to-understand operability to the operator. Various detectors will be described together.

<Encoder 262>
As shown in FIGS. 14A, 14B, 15A, and 15B, the encoder 262 is attached to the rotation shaft of the injection motor 261 and detects the rotation speed (rotation amount) of the injection motor. The output of the encoder 262 is used to detect the movement amount (movement distance) of the piston 211 and the injection amount of the corresponding drug. As the encoder 262, for example, a rotary encoder that measures the rotation speed of a motor or the like can be used.

<Cover open / close detector 271>
As shown in FIG. 1B, the cover open / close detector 271 (see FIG. 13) is provided in the vicinity of the adapter opening 201a and detects that the cover 203 has been opened, that is, the adapter opening 201a has been opened. The cover open / close detector 271 is, for example, a micro switch, and detects that the cover 203 is opened when the opened cover 203 presses the micro switch.

<Adapter mounting detector 272>
32A and 32B are views showing the arrangement of the adapter mounting detector 272. The adapter mounting detector 272 is arranged in the housing 205 facing the adapter space 202a of the main unit 202. The adapter mounting detector 272 is, for example, a micro switch, and when the syringe adapter 100 is mounted in the adapter space 202a, the micro switch is pressed to detect the mounting of the syringe adapter 100.

<Drug information detector 273>
As shown in FIG. 12, the drug information detector 273 is arranged close to the adapter space 202a of the main unit 202. The drug information detector 273 is an RFID antenna that receives information from the radio tag 190 (see FIG. 2). The information acquired by the drug information detector 273 is processed by the control unit 251.

The drug information detector 273 within a predetermined distance from the wireless tag 190 of the syringe adapter 100 mounted in the adapter space 202a so that the information of the wireless tag 190 can be received according to the specifications of the wireless tag 190 and the RFID antenna. Is placed. When it is preferable to bring the drug information detector 273 and the wireless tag 190 close to each other for reception, for example, the drug information detector 273 faces the wireless tag 190 of the attached syringe adapter 100. Be placed. For example, the syringe adapter 100 can be attached to the drug injection device 200 with either the flat surface portion 120p or the flat surface portion 120q facing up, and the wireless tag 190 is either the flat surface portion 120p or the flat surface portion 120q. When provided on only one side, the drug injection device 200 is provided with two drug information detectors 273, even if the syringe adapter 100 is attached with either the flat surface portion 120p or the flat surface portion 120q facing up. The information of the wireless tag 190 may be received. On the contrary, the wireless tag 190 may be provided on both the flat surface portion 120p and the flat surface portion 120q, and the drug injection device 200 may include one drug information detector 273.

<Cap detector 274>
As shown in FIGS. 20A and 21A, the cap detector 274 is arranged in close proximity to the adapter space 202a of the main unit 202 so as to be in contact with the cap 110 of the syringe adapter 100 mounted in the adapter space 202a. The cap detector 274 detects that the cap 110 of the syringe adapter 100 mounted in the adapter space 202a has been removed. The cap detector 274 includes, for example, a lever 274a rotatably supported by a shaft and a microswitch 274b, the lever 274a rotates when the cap 110 is removed, and the rotation of the lever 274a causes the microswitch 274b to rotate. It is pressed. Alternatively, when the syringe adapter 100 is loaded and the lever 274a rotates, the micro switch 274b is pressed, and the removal of the cap 110 causes the micro switch 274b to return, thereby detecting the removal of the cap 110. Further, the cap detector 274 may be configured only by the micro switch and may directly detect the removal of the cap 110.

<Needle guard push detector 275>
As shown in FIGS. 12, 21B and 22B, the needle guard push detector 275 is arranged close to the needle guard 130 of the syringe adapter 100 mounted in the adapter space 202a. The needle guard push detector 275 detects that the needle guard 130 of the syringe adapter 100 mounted in the adapter space 202a is in the push position. The needle guard push detector 275 includes, for example, a lever 275a rotatably supported by a shaft and a micro switch 275b, and when the needle guard 130 moves to the push position, the lever 275a abuts on the protrusion 130k of the needle guard 130. The micro switch 275b is pressed by the rotation of the lever 275a. The needle guard push detector 275 is composed of only a micro switch, and when the needle guard 130 moves to the push position, the protrusion 130k of the needle guard 130 directly pushes the micro switch to move to the push position of the needle guard 130. It may be detected.

<Needle piercing completion detector 276, needle removal completion detector 277>
As shown in FIGS. 17A and 17B, the needle insertion completion detector 276 and the needle removal completion detector 277 are arranged in close proximity to the gearbox 213 of the piston unit 210. The needle sticking completion detector 276 and the needle pulling completion detector 277 detect that the piston unit 210 is in the needle sticking position and the needle pulling position. For example, the gearbox 213 has a light-shielding plate 213a extending in the axial direction A, and the needle sticking completion detector 276 and the needle removal completion detector 277 are each composed of a photo interrupter.

The photointerruptor of the needle removal completion detector 277 is, for example, in a light-shielding state by the light-shielding plate 213a while the piston unit 210 is in the needle-removal position, and is in a translucent state when the piston unit 210 moves from the needle-removal position. The photointerruptor of the needle piercing completion detector 276 is, for example, in a light-shielding state by the light-shielding plate 213a while the piston unit 210 is in a position other than the needle-sticking position, and becomes a translucent state when the piston unit 210 moves to the needle-piercing position. In this way, the completion of needle removal and needle sticking can be detected by electrically detecting the light-shielding / translucent state of the photointerruptor of the needle removal completion detector 277 and the needle sticking completion detector 276, respectively.

<Piston origin detector 278>
As shown in FIGS. 16A and 16B, the piston origin detector 278 is arranged close to the place where the piston 211 moves. The piston origin detector 278 detects that the piston 211 is in a predetermined position. In order to calibrate the detection amount of the encoder 262 based on the detection result of the piston origin detector 278, the predetermined position of the piston 211 may be set anywhere. For example, the piston origin detector 278 detects that the piston 211 is in the open position. In this case, for example, the piston origin detector 278 is a micro switch, and when the piston 211 retracts to the release position, the piston origin detection is performed at one end of the movement range of the piston 211 so that the rear end of the piston 211 presses the micro switch. Place the vessel 278.

<Eject button detector 279>
As shown in FIGS. 18A and 18B, the discharge button detector 279 is located in close proximity to the discharge button 204 or the adapter lock member 241. The eject button detector 279 detects that the eject button 204 has been operated. The discharge button detector 279 is, for example, a micro switch, and the discharge button 204 is pressed by sliding, and the adapter lock mechanism 240 detects that the lock is released.

The positions of these various detectors and the elements constituting the detector are examples, and the detector may be provided at another position, or the detector may be configured by an element other than the micro switch. The micro switch may be a type that is turned on by pressing (PUSH ON) or a type that is turned OFF (PUSH OFF). Further, the drug injection device 200 may not include one or more of these detectors.

(Operation of drug injection system 300)
Hereinafter, with reference to FIGS. 13 and 33 to 52, an example of a control method of the drug injection device 200, an operation of the drug injection system 300 including the syringe adapter 100 and the drug injection device 200, a usage procedure, and an operation method will be described. do. 33 to 41 are perspective views of the drug injection device 200 and the syringe adapter 100 during the operation of the drug injection system 300, and FIGS. 42 to 52 show the control of the drug injection device 200 and the operation of the drug injection system 300. It is a flowchart which shows.

The drug injection device 200 and the control unit 251 can operate in the standby mode and the operation mode, and the control unit 251 can switch between the standby mode and the operation mode. In the standby mode, the control unit 251 can detect only the output of the adapter-mounted detector 272, for example, and other detectors and other configurations are inactive or in a low power consumption standby state.

<Main flow operation, Fig. 42>
The operator attaches the syringe adapter 100 to the drug injection device 200 (S1). Further, the operator removes the cap 110 (S2) and brings the drug injection device 200 into contact with the skin (S3). When the operator presses the injection button 254, the needle is automatically pierced (S4). Further injection of the drug is performed (S5). After the injection of the drug is completed, the needle is automatically removed. (S6), when the operator separates the drug injection device 200 from the injection site, the piston returns (S7). After that, when the operator removes the syringe adapter 100 (S8), the termination process is performed (S9). Hereinafter, each subflow will be described in detail.

<Adapter insertion flow, FIGS. 33, 34, 43>
The drug injection device 200 is operating in the standby mode. While the control unit 251 is operating in the standby mode, when the syringe adapter 100 is attached to the drug injection device 200, the control unit 251 sets the standby mode to the operation mode based on the output of the cover open / close detector 271 and / or the adapter attachment detector 272. Switch. Specifically, the operator slides the cover 203 with a finger or the like (S11) to release the adapter opening 201a, and then inserts the syringe adapter 100 into the drug injection device 200 from the adapter opening 201a (S12). When the adapter mounting detector 272 detects the mounting of the syringe adapter 100 (S13), the control unit 251 switches the standby mode to the operation mode, that is, turns on the main power supply (S14). The control unit 251 maintains the standby mode until the adapter mounting detector 272 detects the mounting of the syringe adapter 100. After the main power is turned on, the process proceeds to the drug identification flow.

The operation mode of the control unit 251 may be switched based on the cover open / close detector 271. The operator may slide the cover 203 with a finger or the like (S11), the cover open / close detector 271 may detect the movement of the cover 203, and the control unit 251 may switch from the standby mode to the operation mode. Alternatively, when the cover open / close detector 271 detects the movement of the cover 203 and the adapter mounting detector 272 detects the mounting of the syringe adapter 100, the control unit 251 may switch from the standby mode to the operation mode.

<Drug identification flow, FIG. 44>
While operating in the operation mode, the control unit 251 causes the alarm 291 to notify the information regarding the drug filled in the syringe 10 acquired by the drug information detector 273 (S15). Specifically, the drug information detector 273 acquires information on the wireless tag 190 mounted on the syringe adapter 100 (S151), and the control unit 251 displays various information such as the expiration date of the acquired drug. Display on 255. For example, textual information such as "This is a drug for XX. The expiration date is XX ...." is displayed on the display device 255 (S152).

<Cap 110 removal flow, FIGS. 35 and 45>
The control unit 251 notifies the alarm 291 to remove the cap 110 of the syringe adapter 100 based on the detection result of the adapter mounting detector 272, and when the cap detector 274 detects the removal of the cap, the next flow. Proceed to. Specifically, the control unit 251 causes the display device 255 to display "Please remove the cap" or the like (S21). The operator removes the cap 110 according to the display (S22). The control unit 251 determines whether or not the cap detector 274 has detected the removal of the cap 110 (S23). When the cap detector 274 detects the removal of the cap, the control unit 251 ends this flow and proceeds to the next flow. If the cap detector 274 does not detect the removal of the cap, this step is repeated.

<Skin contact flow, FIGS. 36, 46>
When the cap detector 274 detects the removal of the cap 110, the control unit 251 notifies the alarm 291 to press the tip of the syringe adapter 100 against the injection site. Specifically, the control unit 251 causes the display device 255 to display "Please hit the injection site" or the like (S31). The operator presses the needle guard 130 against the injection site according to the display (S32). The control unit 251 determines whether or not the needle guard push detector 275 moves the needle guard 130 to the push position, that is, whether the needle guard 130 is in the push position (S33). If detected, the control unit 251 ends this flow and proceeds to the next flow. If the needle guard push detector 275 does not detect the movement of the needle guard 130, this step is repeated.

<Automatic needle stick flow charts 37 and 47>
Based on the detection result of the needle guard push detector 275, the control unit 251 causes the alarm 291 to notify the alarm to press the injection button 254. Specifically, the control unit 251 causes the display device 255 to display "Please press the injection button" or the like (S41). The operator presses the injection button 254 according to the display (S42). The control unit 251 determines whether or not the injection button 254 has been pressed (S43). When the press of the injection button 254 is detected, the control unit 251 causes the display device 255 to display "needle sticking" or the like (S44). If the press of the injection button 254 is not detected, this step is repeated.

Subsequently, the control unit 251 drives the drive unit 230 to advance the piston unit 210 based on the signal obtained by pressing the injection button 254, and stops the drive unit 230 based on the detection result of the needle sticking completion detector 277. Specifically, the control unit 251 receives a signal by pressing the injection button 254 and rotates the needle piercing motor 264 of the drive unit 230 in the forward direction (S45). The piston unit 210 is driven by the needle extraction motor 264 to move forward.

The control unit 251 determines whether or not the needle puncture completion detector 277 has detected that the piston unit 210 has moved from the needle extraction position to the needle puncture position, that is, that the piston unit 210 is in the needle puncture position (S46). .. When detected, the control unit 251 stops the needle pulling-out motor 264 (S47), ends this flow, and proceeds to the next flow. If the needle piercing completion detector 277 does not detect the completion of movement of the piston unit 210 to the piercing position, this step is repeated.

<Injection flow, Fig. 48>
The control unit 251 notifies the alarm 291 that the injection is to be started, drives the injection motor 261 and advances the piston 211 to inject the drug of the syringe 10. Further, the control unit 251 stops the injection motor 261 based on the detection result of the encoder 262. Specifically, the control unit 251 causes the display device 255 to display "injection" or the like (S51), and rotates the injection motor 261 in the normal direction (S52). Further, the control unit 251 detects the output of the encoder 262 and determines whether or not the advanced amount of the piston corresponds to the set dose from the detected amount (S53). When the dose is the set dose, the control unit 251 stops the injection motor 261 (S54). If the dose is less than the set dose, this step is repeated.

Subsequently, the control unit 251 causes the display device 255 to display "Please hold it while in contact with the skin" (S55), and uses the clock 257 to determine whether or not the predetermined holding time has elapsed. Judgment (S56). When the predetermined holding time has elapsed, this flow is terminated and the process proceeds to the next flow. If the retention time is not reached, this step is repeated.

<Automatic needle removal flow, FIGS. 38, 39, 49>
The control unit 251 drives the drive unit 230 to retract the piston unit 210, and stops the drive unit based on the detection result of the needle removal completion detector 277. Further, the alarm 291 is notified so that the drug injection device 200 is separated from the skin, and it is determined whether or not the drug injection device 200 is separated from the injection site. Specifically, the control unit 251 reversely rotates the needle extraction motor 264 of the drive unit 230 (S61), and retracts the piston unit 210. The control unit 251 determines whether or not the needle removal completion detector 277 detects that the piston unit 210 is in the needle removal position (S62). If detected, the control unit 251 stops the injection motor 261 (S63). If the needle removal completion detector 277 does not detect the completion of movement of the piston unit 210 to the needle removal position, this step is repeated.

After that, the control unit 251 causes the display device 255 to display "Injection is completed. Please move away from the skin." (S64), and the needle guard push detector 275 is not in the push position, that is, , It is determined whether or not it is detected that the needle guard 130 is in the initial position (S65). If detected, this flow is terminated and the process proceeds to the next flow. If not detected, repeat this step.

<Piston return flow, Fig. 50>
The control unit 251 drives the injection motor 261 based on the completion of the automatic needle removal flow, that is, the detection result of the needle guard push detector 275, retracts the piston 211, and injects based on the detection result of the encoder 262. The motor 261 is stopped. Specifically, the control unit 251 causes the display device 255 to display "Please wait for a while" (S71), and rotates the injection motor 261 in the reverse direction (S72). The control unit 251 determines whether or not the piston 211 has retracted to the initial position based on the detected amount of the encoder 262 (S73). For example, when the detected amount of the encoder 262 matches the detected amount of the encoder 262 at the time of injecting the drug, the control unit 251 determines that the piston 211 has retracted to the initial position, and stops the injection motor 261 (S74). End this flow and proceed to the next flow. This step is repeated until the detection amount of the encoder 262 reaches a predetermined value.

<Adapter take-out flow, FIGS. 40, 41, 51>
The control unit 251 causes the alarm 291 to slide the discharge button 204 and notify the alarm to pull out the syringe adapter 100. Further, the control unit 251 drives the injection motor 261 to retract the piston 211 based on the detection result of the discharge button detector 279, and stops the injection motor 261 based on the detection result of the origin detector 278.

Specifically, the control unit 251 causes the display device 255 to display such as "Pull the discharge button, take out the adapter, and close the cover." (S81). The operator slides the eject button 204 (S82). The control unit 251 determines whether or not the discharge button detector 279 has detected that the discharge button 204 has been operated (S83). If detected, the control unit 251 reversely rotates the injection motor (S84) to retract the piston 211. If the discharge button detector 279 does not detect the operation of the discharge button 204, this step is repeated.

The control unit 251 determines whether or not the origin detector 278 has detected that the piston 211 is in the open position (S85). If detected, the control unit 251 stops the injection motor (S86). If the origin detector 278 does not detect that the piston 211 is in the open position, this step is repeated.

The control unit 251 initializes or resets the rotation amount of the injection motor 261 by the encoder 262 based on the detection result of the origin detector 278.

The operator takes out the syringe adapter 100 (S87) and closes the cover 203 by hand (S88). The control unit 251 determines whether or not the cover open / close detector 271 has detected that the cover 203 has been closed (S89). If detected, the control unit 251 ends the flow and proceeds to the next flow. If the cover open / close detector 271 does not detect that the cover 203 is closed, this step is repeated.

<End processing flow, FIG. 52>
Based on the detection result of the cover open / close detector, that is, when the cover open / close detector 271 detects that the cover 203 is closed, the control unit 251 tells the alarm 291 that the previous flow is completed. Notify the injection schedule. Further, the control unit 251 drives the injection motor 261 to move forward, moves the piston 211 to the initial position based on the output of the encoder 262, and stops the injection motor 261. Specifically, the control unit 251 causes the display device 255 to display "the next injection date is XX days" (S91), and rotates the injection motor 261 in the forward direction (S92). The control unit 251 determines whether or not the piston 211 has advanced to the initial position based on the detected amount of the encoder 262 (S93). When a predetermined rotation amount set as the initial position is detected, the injection motor 261 is stopped (S94). This step is repeated until the detection amount of the encoder 262 reaches a predetermined value. After that, the control unit 251 turns off the main power supply and switches the operation mode to the standby mode (S95).

As described above, according to the operation of the drug injection system 300 of the present embodiment, various detectors detect various states during the injection operation and notify the operator of the next operation according to the detection result. Therefore, the operator can easily perform the operation of injecting the drug without worrying about whether the operation procedure is correct or not. Further, the injection needle 12 is covered with the needle guard 130 during a series of operations from removing the cap 110 of the syringe adapter 100, injecting the drug, removing the syringe adapter 100 from the drug injection device 200, and discarding the drug. It has been damaged and will not be exposed. Therefore, the operator can use the drug injection system 300 with peace of mind without paying special attention to piercing the fingers with the injection needle 12 or hooking clothes with the exposed injection needle 12. Is.

(Other forms)
The structures of the syringe adapter 100 and the drug injection device 200 described in the above embodiment are examples, and various modifications can be made. In particular, the shapes and positions of the first engaging structure to the seventh engaging structure are not limited to the illustrated examples, and various modifications can be made. Further, the position and detection method of various detectors are not limited to the above-described embodiment, and various modifications can be made. As the spring exemplified as the urging body, various springs such as a coil spring, a pull spring, a leaf spring, and a torsion spring can be used. Further, in addition to the metal spring, various springs made of resin may be used. The elastic member made of a leaf spring or a resin is not limited to the example given in the embodiment, and various elastic bodies can be used.

The information displayed on the display device described in the above embodiment is an example, and other contents may be displayed, instead of the display on the display device, or by sounding the buzzer together with the display on the display device. The operator may be notified.

The syringe adapters, drug injecting devices and drug injecting systems of the present disclosure are suitably used for devices that inject various drugs.

10 Syringe 11 Barrel 11b Flange 12 Injection needle 13 Stopper 13a Screw hole 14 Needle shield 14a Engagement part 15 Drug 100 Syringe adapter 110 Cap 111 Cap body 111d Hole 112 Cap claw 120 Outer cylinder 120a Second tip opening 120b Second insertion port 120c Second columnar space 120e Syringe 120f Fifth engagement structure 120g Opening 120j Contact surface 120k Recessed surface 120p, 120q Flat surface part 120r, 120s Curved surface part 120t Slope 130 Needle guard 130A Cylindrical part 130B Side surface part 130C Opening 130a Third tip opening 130b Insertion port 130c Third columnar space 130g Syringe 130h Contact part 130j Holding part 130k Protrusion 130p, 130q Flat part 130r, 130s Curved part 131 Guide groove 131A Common groove part 131Aa, 131Ba, 131Ca Front end 131Ab, 131Bb, 131Cb Rear end 131B Outward route Groove 131C Return groove 131D Branch convex 131E Third engagement structure 140 Needle guard spring 180 Syringe holding member 180a First tip opening 180b First insertion port 180c Columnar space 180d Protrusion 180e Elastic part 180f Fourth engagement structure 180h End 180p , 180q Flat part 180r, 180s Curved part 181 Lock mechanism 181a First engagement structure 181b Contact surface 181c Elastic part 182a Second engagement structure 190 Wireless tag 200 Drug injection device 201 Exterior case 201a Adapter opening 201b Skin contact surface 201c Adapter Window 201d Display window 201e Discharge button opening 201f Recess 202 Main unit 202a Adapter space 203 Cover 204 Discharge button 205 Housing 210 Piston unit 211 Piston 211a Tip 211b Convex 211c Male screw 212 Piston gear 212b Spur gear 212c Female screw 213 Gear Box 213a Shading plate 214 Gear box 214a Arm 214b Female screw 216 Bearing 220 Support structure 221 Syringe lock member 221a 6th engagement structure 221b Contact part 222 Support member 222a Contact surface 222b Contact part 223 Bounce spring 230 Drive unit 231 Motor gear 232 Intermediate gear 233 Drive screw 233a Spur gear 233b Male screw 240 Adapter lock mechanism 241 Adapter lock member 241a 7th engagement structure 241b Elastic part 241c Base 242 Bounce spring 245 Motor gear 246 Intermediate gear 251 Control part 252 Battery 253 Memory 254 Injection button 255 Display device 256 Buzzer 257 Clock 258 Infrared communication device 259 Wireless communication device 260 Motor driver 261 Injection Motor 262 Encoder 263 Motor driver 264 Needle removal motor 271 Cover open / close detector 272 Adapter mounting detector 273 Drug information detector 274 Cap detector 274a Lever 274b Micro switch 275 Needle guard push-in detector 275a Lever 275b Micro switch 276 Needle insertion completion detection Device 277 Needle removal completion detector 278 Piston origin detector 279 Discharge button detector 291 Alarm 292 Communication device 293 Drive device 295 Detector 300 Drug injection system

Claims (18)

A syringe holding member having a first insertion slot and a first tip opening and a first columnar space located between the first insertion slot and the first tip opening, having an injection needle and a stopper, and a drug. A syringe holding member for accommodating a syringe filled with a syringe in the first columnar space with at least a part of an injection needle protruding from the first tip opening.
It has an inner surface that is located between the second insertion slot and the second tip opening and the second insertion slot and the second tip opening and defines a second columnar space into which the syringe holding member is inserted. An outer cylinder that movably supports the syringe holding member between a needle insertion position in which at least a part of the injection needle protrudes from the second tip opening and a needle extraction position in which the injection needle does not protrude from the second tip opening. When,
A needle guard arranged in the second columnar space of the outer cylinder and movable between an initial position in which at least a part protrudes from the second tip opening and a pushing position in which the outer cylinder does not protrude.
A spring that urges the needle guard in the direction of the initial position,
Equipped with
The syringe holding member has a first engaging structure urged on the inner side surface side of the outer cylinder in a state of being inserted into the second columnar space of the outer cylinder.
The outer cylinder has a second engaging structure that engages with the first engaging structure of the syringe holding member when the syringe holding member is in the needle removal position.
The needle guard has a tubular portion including a portion of the outer cylinder that protrudes from the second tip opening when in the initial position, and a side surface portion connected to the tubular portion.
The side surface portion is located between the inner side surface of the outer cylinder and the syringe holding member in the second columnar space of the outer cylinder.
When the needle guard moves to the pushing position, the side surface portion pushes down the second engaging structure of the syringe holding member so as to be separated from the inner side surface.
When the needle guard is in the initial position and the syringe holding member is in the needle pulling position, the syringe holding member is in a locked state with respect to the outer cylinder.
When the needle guard is in the pushing position and the syringe holding member is in the needle pulling position, the syringe holding member is in an unlocked state with respect to the outer cylinder.
After the needle guard moves from the initial position to the pushing position, the syringe holding member moves from the needle pulling position to the needle piercing position, and then the syringe holding member returns to the needle pulling position, and the needle guard moves. When returning to the initial position, the needle guard is locked with respect to the syringe holding member.
Adapter for syringe. The needle guard has a guide groove provided on the side surface portion, and the needle guard has a guide groove.
The syringe holding member has a protrusion that is inserted into the guide groove and is elastically supported in the tangential direction.
The guide groove extends in the moving direction of the needle guard and includes a common groove portion having a front end and a rear end, respectively, an outward groove portion and a return groove portion.
The common groove portion, the outward route groove portion, and the front end of the return route groove portion are located on the cylindrical portion side, respectively.
The outward groove portion and the return groove portion are arranged in the circumferential direction on the side surface portion.
The front end of the outward groove portion and the return groove portion is connected to the rear end of the common groove portion.
The side surface portion is provided at the branch convex portion protruding toward the outward path groove portion and the rear end of the return path groove portion in the vicinity of the front end between the outward path groove portion and the return path groove portion, and is provided at the rear end of the syringe holding member. The syringe adapter according to claim 1 , which has a third engagement structure that engages with a protrusion. When the needle guard is in the initial position and the syringe holding member is in the needle pulling position, the protrusion of the syringe holding member is located at the rear end of the outward groove portion of the guide groove.
As the needle guard is pushed into the outer cylinder, the protrusion moves relatively toward the front end side of the outward groove portion, and when the needle guard moves to the pushing position, the protrusion moves to the outward groove portion. Located at the front end of the
When the syringe holding member moves from the needle withdrawal position to the needle piercing position, the protrusion overcomes the branch convex portion and moves to the front end via the rear end of the common groove portion.
When the syringe holding member returns from the needle puncture position to the needle removal position, the protrusion moves from the front end to the rear end of the common groove portion to the front end of the return groove portion.
The syringe adapter according to claim 2, wherein when the needle guard returns to the initial position, the protrusion is located at the rear end of the return groove portion and engages with the third engagement structure. The needle guard and the syringe holding member have two guide structures composed of the guide groove and the protrusion.
The syringe adapter according to claim 3 , wherein the two guide structures are arranged symmetrically with respect to the axis of the second columnar space of the outer cylinder. The syringe has a needle shield that covers the needle and has a needle shield.
Any one of claims 1 to 4 , which has a hole that frictionally couples with the needle shield, covers the second tip opening of the outer cylinder, and further has a cap that is detachably supported by the outer cylinder. Adapter for syringe described in. The syringe adapter according to any one of claims 1 to 5 , further comprising a wireless tag storing information about a drug filled in the syringe. The syringe holding member has a fourth engaging structure and has a fourth engaging structure.
The syringe adapter according to claim 1, wherein the outer cylinder has a fifth engaging structure provided on the outer surface. An exterior case having an adapter space to which the syringe adapter according to claim 7 can be mounted, an adapter opening communicating with the adapter space, and a cover for opening and closing the adapter opening.
To the piston, the piston gear that drives the piston in the direction of the piston axis, the gearbox that supports the piston and the piston gear, and the syringe holding member of the syringe adapter that is connected to the gearbox and inserted into the adapter space. A syringe lock member having a sixth engaging structure that engages with the fourth engaging structure provided is included, and the syringe holding member is moved between the needle sticking position and the needle pulling position, and the needle is pulled out. A piston unit that advances the stopper with the piston, and
A drive unit that includes a needle extraction motor and at least one gear and drives the piston unit in the direction of the piston axis.
The injection motor that drives the piston gear and
A control unit that controls the drive unit and the injection motor,
With memory
With an alarm
A drug infusion device equipped with. In the piston unit, the piston is in an initial position where the sixth engaging structure can engage the fourth engaging structure of the syringe adapter without the piston coming into contact with the stopper of the syringe. And the release position where the engagement between the sixth engagement structure and the fourth engagement structure of the syringe adapter is released, and the stopper is inserted into the inside of the syringe by advancing from the initial position. The drug injection device according to claim 8 , which can take an injection position. A cover open / close detector that detects the open / close of the cover that opens / closes the adapter opening, and
It is equipped with an adapter mounting detector that detects the insertion of the syringe adapter into the adapter space.
The control unit can operate in a standby mode capable of detecting the output of the cover open / close detector and / or the output of the adapter mounting detector, and an operation mode capable of operating the drug injection device. And
When the syringe adapter is attached while the control unit is operating in the standby mode, the control unit switches the standby mode to the operation mode based on the output of the cover open / close detector and / or the adapter attachment detector. The drug injection device according to claim 9 . The syringe adapter further comprises a wireless tag containing information about the drug filled in the syringe.
The drug injection device further includes a drug information detector that reads out information stored in the wireless tag.
The drug injection device according to claim 10, wherein the control unit causes the alarm to notify information about a drug filled in the syringe acquired by the drug information detector while operating in the operation mode. The syringe has a needle shield that covers the needle.
The syringe adapter has a hole that engages with the needle shield, covers the second tip opening of the outer cylinder, and further has a cap that is detachably supported by the outer cylinder.
The drug injection device is
A cap detector that detects the detachment of the cap of the syringe adapter, and
An adapter lock member having a seventh engaging structure that engages with the fifth engaging structure of the mounted syringe adapter and urged to come into contact with the outer surface of the syringe adapter.
Equipped with
The control unit notifies the alarm to remove the cap of the syringe adapter based on the output of the adapter-mounted detector, and when the cap detector detects the removal of the cap, the alarm is notified. The drug injection device according to claim 10 or 11 , which notifies the patient to press the tip of the syringe adapter against the injection site. A needle guard push detector that detects that the needle guard of the syringe adapter is in the push position, and
The injection button provided on the outer case and
Further prepare
The needle guard push detector detects that the needle guard of the syringe adapter is in the push position, and detects that the needle guard is in the push position.
The drug injection device according to claim 12 , wherein the control unit causes the alarm to notify the alarm to press the injection button based on the detection result of the needle guard push detector. A needle piercing completion detector that detects that the piston unit is in the piercing position, and
A needle removal completion detector that detects that the piston unit is in the needle removal position, and
Further equipped with an encoder for detecting the rotation of the injection motor,
The control unit
Based on the signal obtained by pressing the injection button, the drive unit is driven to move the piston unit forward.
The drive unit is stopped based on the detection result of the needle sticking completion detector, and the driving unit is stopped.
The injection motor is driven, the piston is advanced, and the drug is injected.
The injection motor is stopped based on the detection result of the encoder, and the injection motor is stopped.
After a lapse of a predetermined time, the drive unit is driven to retract the piston unit.
The drive unit is stopped based on the detection result of the needle removal completion detector, and the needle removal completion detector is stopped.
The drug injection device according to claim 13 , wherein the alarm is notified to move the drug injection device away from the skin. The control unit
Based on the detection result of the needle guard push detector, the injection motor is driven and the piston is retracted.
The drug injection device according to claim 14 , wherein the injection motor is stopped based on the detection result of the encoder. The adapter lock member is located in the outer case and moves the adapter lock member so as to disengage the fifth engagement structure of the mounted syringe adapter and the seventh engagement structure of the adapter lock member. With the eject button,
A discharge button detector that detects the operation of the discharge button, and
Further equipped with an origin detector for detecting that the piston has retracted to the release position.
The control unit
Slide the eject button to notify the syringe adapter to be pulled out.
Based on the detection result of the discharge button detector, the injection motor is driven to retract the piston.
The drug injection device according to claim 15 , wherein the injection motor is stopped based on the detection result of the origin detector. The control unit drives the injection motor based on the detection result of the cover open / close detector when the syringe adapter is removed and the cover is closed, and the piston is moved to the initial position based on the output of the encoder. Move it, stop the injection motor,
The drug injection device according to claim 16 , wherein the operation mode is switched to the standby mode. A drug injection system comprising the syringe adapter according to claim 7 and the drug injection device according to claim 8 .

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