JP7022247B1 - Purified water supply system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a purified water supply system capable of reducing the possibility of contaminated purified water and supplying purified water more reliably to a use point. SOLUTION: The purified water supply device 20 includes a purified water production device 10 and a purified water supply device 20 for circulating and supplying purified water to a use point 60, and the purified water supply device 20 is provided with purified water supplied from the purified water production device 10. The supply line S to be distributed, the purified water tank 30 for storing the purified water supplied from the supply line S, and the purified water stored in the purified water tank 30 are supplied to the use point 60, and the purified water is supplied from the use point 60. A circulation line L for returning purified water to the tank 30 and a filter device 40 for filtering purified water are provided, and the filter device 40 is not provided in the circulation line L but is provided in the supply line S. .. Further, it includes a CIP / SIP device 50 that separates the purified water production device 10 and cleans and sterilizes the purified water supply device 20. [Selection diagram] Fig. 1

Description

The present invention relates to a purified water supply system that supplies purified water to a youth point via a circulating pipe.

Conventionally, a purified water supply system for supplying purified water to a point of use is known (see, for example, Patent Document 1). The purified water supply system consists of a purified water production device and a purified water supply device. The purified water supply device is provided with a circulation line for temporarily storing the purified water produced by the purified water production device in the tank and circulating the purified water between the tank and the point of use.

Since purified water is used as a pharmaceutical solution such as an injection solution, it is required to be sufficiently sterilized. In the purified water supply system described in Patent Document 1, a filter is provided in the circulation line, and the purified water that has been circulated without being used at the point of use is filtered and sterilized.

However, the circulation line may be prohibited from being provided with a filter device by the guidelines for the production of pharmaceutical solutions from the viewpoint of preventing contamination of purified water.

On the other hand, in the purified water production apparatus, there is a configuration in which purified water sterilized by a filter apparatus is produced and the purified water is supplied to the purified water supply apparatus. In such a configuration, contamination may occur while supplying purified water from the purified water production apparatus to the purified water supply apparatus. In particular, the purified water supply device is often installed physically away from the purified water production device. For this reason, the piping becomes long, and the number of parts such as valves and joints attached to the piping increases, so it is necessary to take measures in consideration of the possibility that purified water will be contaminated.

Japanese Unexamined Patent Publication No. 2018-102717

In view of such circumstances, it is an object of the present invention to provide a purified water supply system capable of reducing the possibility of contaminated purified water and more reliably supplying sterilized purified water to a point of use. And.

One aspect of the present invention for achieving the above object is a purified water producing apparatus for producing purified water, a purified water supply apparatus for circulating and supplying purified water produced by the purified water producing apparatus to a point of use, and the above-mentioned. The purified water supply device is provided with a cleaning device for cleaning by supplying a cleaning liquid to the purified water supply device and a sterilization device for sterilization by supplying a sterilization fluid, and the purified water supply device is supplied from the purified water production device. The supply line through which the purified water is distributed, the purified water tank that stores the purified water supplied from the supply line, and the purified water stored in the purified water tank are supplied to the use point, and from the use point. A circulation line for returning purified water to the purified water tank and a filter device for filtering purified water are provided, and the filter device is not provided in the circulation line but is provided in the supply line. The cleaning device and the sterilizing device are connected to the supply line at a third branch point on the upstream side of the filter device, and the cleaning liquid and the sterilizing fluid are passed through the supply line to the filter device and the purified water tank. And the first circulation line that supplies the purified water to the circulation line and supplies the purified water stored in the purified water tank to the use point, and the first circulation line that returns the purified water from the use point to the purified water tank. The first circulation line includes two circulation lines, the first discharge line branched at the first branch point on the upstream side of the use point is connected to the first circulation line, and the second circulation line is connected to the use point. A second discharge line branched at a second branch point on the downstream side is connected, a first valve is provided between the first branch point and the use point of the first circulation line, and the second circulation line is provided. A second valve is provided between the second branch point and the use point, a third valve and a fourth valve are provided in each of the first discharge line and the second discharge line, and the supply line is provided with a third valve and a fourth valve. A fifth valve is provided on the purified water production apparatus side of the third branch point, and in the cleaning apparatus and the sterilization apparatus, the first valve, the second valve and the fifth valve are closed, and the fifth valve is closed. With the third valve and the fourth valve open , the cleaning liquid and the sterilizing liquid supplied to the filter device and the purified water tank via the supply line are transferred from the purified water tank to the first . The second circulation lie is discharged from the purified water tank to one circulation line, the first branch point, and the first discharge line. The purified water supply system is characterized in that the water is discharged to the second branch point and the second discharge line .

INDUSTRIAL APPLICABILITY According to the present invention, there is provided a purified water supply system capable of reducing the possibility of contaminated purified water and more reliably supplying purified purified water to a point of use.

It is a schematic block diagram of the purified water supply system including the production line which treats a process liquid. It is a schematic block diagram for demonstrating the supply process of a purified water supply system. It is a schematic block diagram for demonstrating the circulation supply process of a purified water supply system. It is a schematic block diagram for demonstrating the washing sterilization process of a purified water supply system.

FIG. 1 is a schematic configuration diagram of a purified water supply system according to the present embodiment. The purified water supply system 1 of the present embodiment includes a purified water producing device 10 and a purified water supply device 20.

Although not particularly shown, the purified water producing apparatus 10 is composed of an apparatus group such as a filter apparatus, a heat exchanger, and an EDI apparatus, and produces purified water from normal water. Since such a purified water production apparatus 10 is known, detailed description thereof will be omitted.

The purified water supply device 20 includes a supply line S, a purified water tank 30, a circulation line L, a filter device 40, and a CIP / SIP device 50, and supplies purified water to the use point 60. Use points are facilities, equipment, places, etc. where purified water is used.

The purified water tank 30 is a tank for storing purified water. The supply line S is a pipe through which purified water supplied from the purified water production apparatus 10 flows. Purified water is supplied to the purified water tank 30 from the purified water production apparatus 10 via the supply line S.

The circulation line L has a configuration including a first circulation line L1 and a second circulation line L2. The first circulation line L1 is a pipe for supplying the purified water stored in the purified water tank 30 to the use point 60. The second circulation line L2 is a pipe for returning purified water from the use point 60 to the purified water tank 30.

A pump P is provided on the first circulation line L1. The pump P is a device for distributing purified water to the first circulation line L1. Purified water is supplied from the purified water tank 30 to the use point 60 by the pump P, and the purified water returns from the use point 60 to the purified water tank 30.

The first discharge line E1 branched at the branch point D1 is connected to the first circulation line L1. The second discharge line E2 branched at the branch point D2 is connected to the second circulation line L2. These first discharge line E1 and second discharge line E2 are collectively referred to as discharge line E.

The various lines described above do not have to be composed of a single pipe, and may be a combination of a plurality of pipes. Further, various devices may be provided on the way.

The filter device 40 is a device provided with a filter for filtering purified water, and is provided in the supply line S. The purified water supplied from the purified water production apparatus 10 is processed by the filter apparatus 40 and stored in the purified water tank 30. As the filter device 40, one that performs ultrafiltration is preferable.

The CIP / SIP device 50 is a cleaning device for performing clean-in-place cleaning (CIP) and a sterility device for performing clean-in-place sterility (SIP) of the purified water supply device 20. Specifically, the CIP / SIP device 50 is connected to the supply line S at the branch point D3 via the cleaning line C. The CIP / SIP device 50 supplies the cleaning liquid and the sterilizing fluid to the filter device 40, the purified water tank 30, and the circulation line L constituting the purified water supply device 20 via the supply line S. The purified water supply device 20 is washed and sterilized by the washing liquid and the sterilizing fluid. After cleaning and sterilization, the cleaning liquid and the sterilizing fluid are discharged from the discharge line E. A processing device (not shown) is connected to the discharge line E, and the cleaning liquid and the sterilizing fluid are processed by the processing device. The cleaning liquid is water to which an alkaline agent such as caustic soda is added, water to which an acidic agent is added, water containing a surfactant, or water containing no such agent. Of course, these may be used together. The sterilizing fluid is hot water or steam obtained by heating purified water or the like.

Further, the valve V1 is provided on the use point 60 side of the branch point D1 in the first circulation line L1. The valve V2 is provided on the use point 60 side of the branch point D2 in the second circulation line L2. The valve V3 is provided on the first discharge line E1 and the valve V4 is provided on the second discharge line E2. The valve V5 is provided on the supply line S on the purified water production apparatus 10 side with respect to the branch point D3. The valve V6 is provided on the cleaning line C. The valves V1 to V6 are valves that can be controlled by a control device described later. Specifically, it is a solenoid valve that can be switched to either a fully open or fully closed state, or a control valve that can adjust the opening degree.

Although not particularly shown, the purified water supply system 1 includes a control device for controlling the above-mentioned components. The control device is a programmable logic controller (PLC) or the like. The control device mainly controls to execute the following processes.
-Supply process: Process of supplying purified water from the purified water production device 10 to the purified water supply device 20-Circulation supply process: Process of circulating purified water from the purified water tank 30 to the point of use 60-Washing sterilization process: Purified water Process of cleaning and sterilizing (CIP and SIP) of the feeder 20-Completeness test process: Process of performing a completeness test on the filter device 40

The supply process executed by the purified water supply system 1 having the above-described configuration will be described with reference to FIG. It should be noted that the valves V1 to V6 are open if they are painted white, and closed if they are painted black, and the same applies to the following figures.

The control device opens the valve V1, the valve V2, and the valve V5, and closes the valve V3, the valve V4, and the valve V6. The control device operates a pump or the like (not shown) to supply the purified water produced by the purified water producing device 10 to the supply line S. The purified water passes through the supply line S, is sterilized by the filter device 40, and is stored in the purified water tank 30. The supply process does not have to be performed separately from the circulation supply process described later, and may be performed in parallel.

The supply process executed by the purified water supply system 1 having the above-described configuration will be described with reference to FIG. The control device opens the discharge port (not shown) of the purified water tank 30 and operates the pump P. As a result, purified water is supplied from the purified water tank 30 to the use point 60 via the first circulation line L1. Further, the purified water not used at the use point 60 returns to the second circulation line L2. This purified water is also returned to the purified water tank 30 by the pump P. In this way, the control device is connected between the purified water tank 30 and the use point 60 in the order of purified water tank 30 → first circulation line L1 → use point 60 → second circulation line L2 → purified water tank 30. Circulate and supply purified water.

Further, the control device controls the supply of purified water by the purified water production device 10 so that a constant amount of purified water is maintained in the purified water tank 30 in the supply process and the circulation supply process. Specifically, the purified water tank 30 is provided with various sensors such as a water level gauge for measuring the amount of purified water. When the value by the sensor falls below a certain value, the control device controls the opening and closing of the valve V5 to supply purified water from the purified water producing device 10 to the purified water tank 30. Further, when the value by the sensor exceeds a certain value, the control device reduces the amount of purified water supplied from the purified water production device 10 to the purified water tank 30 by controlling the opening and closing of the valve V5, or zeros (supply). Stop). Of course, the production of purified water by the purified water production apparatus 10 may be stopped.

FIG. 4 will be used to describe a wash sterility process performed in the purified water supply system 1 having the above configuration. The control device closes the valve V1, the valve V2, and the valve V5, and opens the valve V3, the valve V4, and the valve V6. That is, each valve is opened and closed so that the cleaning liquid and the sterilizing fluid do not reach the purified water production apparatus 10 and the use point 60.

The control device causes the CIP / SIP device 50 to supply the cleaning liquid to each part of the purified water supply device 20. The cleaning liquid cleans the filter device 40, the supply line S, the purified water tank 30, and the circulation line L, and is discharged from the discharge line E. Next, the control device causes the CIP / SIP device 50 to supply the sterilizing fluid to each part of the purified water supply device 20. The sterilizing fluid cleans the filter device 40, the supply line S, the purified water tank 30, and the circulation line L, and is discharged from the discharge line E. In this way, the purified water supply device 20 is clean-in-place and sterilized by the cleaning liquid and the sterilizing fluid.

Although not particularly shown, an integrity test process performed by the purified water supply system 1 having the above-described configuration will be described.

The integrity test is a test for confirming that the filter provided in the filter device 40 has no physical defects and has a predetermined performance. Since it is confirmed by this completeness test that the filtering function of the filter is not impaired, it is possible to ensure that the purified water flowing through the filter device 40 and supplied to the purified water tank 30 is sterile.

As the integrity test process, known ones can be applied, for example, as follows. The control device wets the filter provided in the filter device 40 with water. Then, the control device supplies a gas to the primary side (purified water production device 10 side) of the filter, and makes the gas an appropriate pressure below the bubble point. Based on the pressure drop of the gas on the primary side, the controller determines if the function of the filter is maintained.

Although not shown in particular, the purified water supply system 1 is equipped with various devices used in the integrity test. For example, the device for supplying water for moistening the filter of the filter device 40 may be a purified water production device 10 or a water supply device different from the purified water. Further, the purified water supply system 1 is also provided with a device for supplying gas to the primary side of the filter device 40 and applying pressure. Further, the water used in the integrity test process is discharged from the circulation line L via the discharge line E.

The purified water supply system 1 having the configuration described above includes the purified water production device 10 and the purified water supply device 20, and circulates and supplies purified water to the use point 60 via the circulation line L. The filter device 40 is not provided on the circulation line L, but is provided between the purified water producing device 10 and the purified water tank 30.

According to such a configuration, even if the purified water is contaminated in the supply line S connecting the purified water production apparatus 10 to the purified water tank 30, the filter apparatus 40 removes the contamination and demands the pharmaceutical solution. Purified water of the desired level can be supplied to use point 60 via the circulation line L.

In addition, the purified water production apparatus 10 is generally not sterilized by steam, and most of the operations are such that the filter or the like is replaced according to the operating time. Although it is still possible to produce a sufficient level of purified water, it is necessary to take measures against the risk of contamination of the purified water with the purified water production apparatus 10. In the purified water supply system 1 of the present invention, the filter device 40 becomes a risk countermeasure not only for the supply line S but also for the contamination generated in the purified water production apparatus 10, and the possibility that the purified water is contaminated is reduced. More reliably sterilized purified water can be supplied to use point 60.

Further, it is assumed that the filter device 40 is installed on the circulation line L. In this case, the circulating purified water is sterilized by the filter device 40, and the filter device 40 itself also replaces the filter as appropriate, so that the risk of contamination of the purified water is low. However, in the unlikely event that a contamination source remains in the filter device 40 provided in the circulation line L, there is a risk that the circulating purified water will be contaminated. It is conceivable to clean and sterilize the filter device 40, but there is still a risk.

However, since the purified water supply system 1 of the present invention does not provide the filter device 40 on the circulation line L, the above-mentioned risk cannot occur in the first place. Since the filter device 40 is not provided on the circulation line L in this way, the risk of contamination originating from the filter device 40 can be avoided in the circulation line L, and the guidelines as described in the background art can be observed.

Further, the purified water supply system 1 includes a CIP / SIP device 50 for cleaning and sterilizing the purified water supply device 20. The entire purified water supply device 20 is washed and sterilized by the CIP / SIP device 50. In particular, since the filter device 40 is also washed and sterilized, it is ensured that the filter device 40 is sterile. Since the filter device 40 is sterile, it is possible to more reliably supply sterile purified water from the purified water production device 10 to the purified water tank 30.

In the past, in most cases, the filter or the like was replaced according to the operating time without cleaning or steam sterility. Therefore, it is not necessary to provide a CIP / SIP device 50 for cleaning and sterilizing the filter device 40, the purified water tank 30, and the circulation line L. Furthermore, there is no device corresponding to the 1st-5th valve V1-V5 or control thereof. Therefore, it was not possible to perform cleaning and sterilization with the purified water supply device 20 separated from the purified water production device 10 and the use point 60.

On the other hand, in the purified water supply system 1 of the present invention, the first discharge line E1 and the second discharge line E2 are connected to the circulation line L as a configuration for washing and sterilizing, and the CIP / SIP device 50 is used during washing and sterility. The 1st-5th valves V1-V5 are provided so that the cleaning liquid and the sterility liquid can flow from the supply line S to the purified water tank 30, the circulation line L, and the discharge line E.

By controlling the opening and closing of these 1st-5th valves V1-V5, the purified water supply device 20 (consisting of the supply line S, the purified water tank 30, the circulation line L, and the discharge line E) is connected to the purified water production device 10 and the purified water production device 10. Cleaning and sterilization can be performed with the use point 60 separated.

By being able to perform such cleaning and sterility, the present invention is particularly useful in the following cases. That is, in the case where the purified water production device 10 and the purified water supply device 20 are managed by separate management bodies, and the management body on the purified water supply device 20 side cannot be aware of the filter replacement of the purified water production device 10. be.

In such a case, the management entity of the purified water supply device 20 cannot replace the filter because the purified water production device 10 is not a control target. Therefore, it is appropriate to keep in mind the risk that the purified water supplied from the purified water production apparatus 10 is contaminated.

In the purified water supply system 1, the purified water from the purified water production device 10 can be sterilized by the filter device 40 provided in the supply line S, and the filter device 40, the purified water tank 30, and the circulation line L are washed and cleaned. Can be sterilized. As a result, the filter device 40 provided in the supply line S can be used in a clean state at all times regardless of the deterioration status of the filter of the purified water production device 10, so that purified water with guaranteed sterility can be supplied more reliably. can.

In addition, the purified water supply system 1 can perform an integrity test on the filter device 40. As a result, the integrity of the filter device 40 can be ensured, and the purified water that flows through the filter device 40 and is supplied to the purified water tank 30 can be guaranteed to be sterile.

Although one embodiment of the present invention has been described above, of course, the present invention is not limited to the above-described embodiment, and the addition, omission, and substitution of configurations are added, omitted, and substituted within the scope of the gist of the present invention. And other changes are possible.

For example, the purified water tank 30, the supply line S, the filter device 40, the circulation line L, and the use point 60 are one system, but the configuration is not limited to this. The present invention can be applied even when all or part of them are made redundant.

Further, the purified water supply system 1 exemplifies the case where purified water used for a pharmaceutical solution such as injection water is used, but the present invention is not limited to such applications, and is also applicable to the case of supplying purified water for various purposes. be able to.

C ... Cleaning line, E ... Discharge line, L ... Circulation line, S ... Supply line, 1 ... Purified water supply system, 10 ... Purified water production equipment, 20 ... Purified water supply equipment, 30 ... Purified water tank, 40 ... Filter device, 50 ... CIP / SIP device (cleaning device, sterilization device), 60 ... Use point

Claims (2)

Purified water production equipment that produces purified water,
A purified water supply device that circulates and supplies purified water produced by the purified water production device to use points.
The purified water supply device is provided with a cleaning device for cleaning by supplying a cleaning liquid and a sterilization device for sterilizing by supplying a sterilizing fluid.
The purified water supply device is
A supply line through which purified water supplied from the purified water production device is distributed,
A purified water tank that stores purified water supplied from the supply line,
A circulation line for supplying the purified water stored in the purified water tank to the use point and returning the purified water from the use point to the purified water tank.
Equipped with a filter device that filters purified water,
The filter device is not provided in the circulation line, but in the supply line.
The cleaning device and the sterilizing device are connected to the supply line at a third branch point on the upstream side of the filter device, and the cleaning liquid and the sterilizing fluid are passed through the supply line to the filter device and the purified water. Supply to the tank and the circulation line
The circulation line includes a first circulation line that supplies purified water stored in the purified water tank to the use point, and a second circulation line that returns purified water from the use point to the purified water tank.
A first discharge line branched at a first branch point on the upstream side of the use point is connected to the first circulation line.
A second discharge line branched at a second branch point downstream of the use point is connected to the second circulation line.
A first valve is provided between the first branch point and the use point of the first circulation line.
A second valve is provided between the second branch point and the use point of the second circulation line.
A third valve and a fourth valve are provided in each of the first discharge line and the second discharge line, respectively.
The supply line is provided with a fifth valve on the purified water production apparatus side of the third branch point.
The cleaning device and the sterilizing device have the supply line in a state where the first valve, the second valve and the fifth valve are closed, and the third valve and the fourth valve are opened. The cleaning liquid and the sterilizing fluid supplied to the filter device and the purified water tank are discharged from the purified water tank to the first circulation line, the first branch point, and the first discharge line. A purified water supply system characterized by discharging water from a purified water tank to the second circulation line, the second branch point, and the second discharge line . In the purified water supply system according to claim 1,
A first device for supplying water for moistening the filter of the filter device, and
A second device that supplies gas to the primary side of the filter device and applies pressure, and
The first device supplies water to the filter device, and the second device supplies gas to the primary side of the filter device to bring the gas to a pressure below the bubble point, thereby reducing the pressure of the gas on the primary side. A purified water supply system comprising a control device that performs a completeness test to determine whether the function of the filter is maintained based on the basis.

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