JP7020885B2 - Trace liquid collection device adapter and trace liquid collection device - Google Patents

Description

The present invention relates to a trace liquid collection device used when collecting a liquid such as blood, and an adapter for the trace liquid collection device.

Patent Document 1 discloses a trace liquid sampling device. This trace liquid collection device has a coupling hole for inserting and temporarily fixing the capillary and a suction side hole for sucking liquid such as blood collected by the capillary from the capillary side in the main body. Is.

In this trace liquid collection device, the liquid is sucked by the capillary phenomenon of the capillary. Therefore, it is possible to carry a small amount of blood directly to the device suction unit.

Japanese Patent No. 4807587

However, when a certain amount or more of the liquid is sucked, the weight of the liquid exceeds the surface tension of the liquid, and the liquid may fall from the capillary by its own weight.

The present invention has been made in view of the current situation in such a trace liquid collecting device, and an object thereof is that the liquid drops by its own weight between the time when the liquid is collected and the time when the liquid is sucked by the suction tube of the measuring device. It is to provide an adapter for a trace liquid collection device and a trace liquid collection device that can reduce the risk.

The adapter of the trace liquid sampling device according to the embodiment of the present invention has a first hole into which one end of a capillary for collecting the liquid to be inspected is inserted, and the capillary is temporarily fixed by this insertion, and the first hole. A first passage having a first space following , a second hole into which a suction tube for sucking a liquid collected by the capillary is inserted, and a second space communicating with the second hole. It has a second passage that communicates with the first passage, and has a first line extending in the longitudinal direction in the center of the first passage and a longitudinal direction in the center of the second passage. The angle between the second line and the second line is 90 degrees to 90 degrees ± 10 degrees.

In the trace liquid collecting device according to the embodiment of the present invention , one end of a capillary for collecting the liquid to be inspected is inserted, and the first hole in which the capillary is temporarily fixed by this insertion and the first hole are continued. A first passage having a first space , a second hole into which a suction tube for sucking the liquid collected by the capillary is inserted, and a second space communicating with the second hole . A second line having a second passage communicating with the first passage and extending longitudinally through the center of the first passage and a second line extending longitudinally through the center of the second passage. It is provided with an adapter for a trace liquid sampling device having an angle formed with the line of 90 degrees to 90 degrees ± 10 degrees, and a capillary inserted in the first hole.

According to the present invention, the angle between the first line extending in the longitudinal direction in the center of the first passage and the second line extending in the longitudinal direction in the center of the second passage is 90 degrees to 90 degrees ± 10. Therefore, if the opening of the second hole is turned upward after the liquid is collected, the risk of the collected liquid falling under its own weight can be reduced. Therefore, a larger amount of liquid can be retained in the trace liquid sampling device, and it is possible to prevent a decrease in measurement accuracy due to a small amount of liquid for analysis.

The perspective view which shows the embodiment of the adapter of the trace liquid sampling apparatus which concerns on this invention. FIG. 1A is a cross-sectional view taken along the line AA of FIG. The perspective view which shows the embodiment of the trace liquid collecting apparatus which concerns on this invention. The cross-sectional view which cut the trace liquid sampling instrument of FIG. 3 by the same cross section as FIG. The figure which added the auxiliary line explaining the angle of the 1st hole and the 2nd hole to the AA sectional view of FIG. In the cross-sectional view of the trace liquid collecting instrument shown in FIG. 4, a cross-sectional view showing a state in which a suction tube is inserted into a second hole. The perspective view which shows the assembly jig used when assembling the trace liquid sampling instrument which concerns on embodiment of this invention. The perspective view which shows the 1st stage of the process of assembling the trace liquid sampling instrument which concerns on embodiment of this invention. The perspective view which shows the 2nd stage of the process of assembling the trace liquid sampling instrument which concerns on embodiment of this invention. The perspective view which shows the 3rd stage of the process of assembling the trace liquid sampling instrument which concerns on embodiment of this invention. The perspective view which shows the 4th stage of the process of assembling the trace liquid sampling instrument which concerns on embodiment of this invention.

Hereinafter, embodiments of the trace liquid sampling instrument adapter and the trace liquid sampling instrument according to the present invention will be described with reference to the accompanying drawings. In each figure, the same components are designated by the same reference numerals, and duplicate description will be omitted. The adapter of the trace liquid sampling device according to the present invention is configured so that a perspective view is shown in FIG. 1 and a sectional view taken along the line AA of FIG. 1 is shown in FIG. The trace liquid collection device is made of resin such as glass and plastic.

The adapter 100 of the trace liquid collection device has a main body block 30. The main body block 30 is a block to which a capillary is attached and a port is provided to provide a suction tube for sucking the liquid collected by the capillary. In the present embodiment, the main body block 30 includes a base portion 10 having a rectangular parallelepiped shape, and a protruding tubular body 20 protruding outward from the first surface 31 of the base portion 10. Further, when the projecting cylinder 20 is viewed from the front (the surface of the circular end portion of the projecting cylinder 20), the knob portion 11 is provided so as to project on, for example, the right side wall surface of the base portion 10. The knob portion 11 has a flat plate shape and has a size that allows the operator to pinch it between the thumb and the index finger.

The projecting cylinder 20 is provided on the first surface 31 of the main body block 30 at a position closer to the bottom side than the central portion of the base 10. The protruding cylinder 20 has a first hole 21 having a predetermined diameter from the center of the circular front surface toward the base 10. The first hole 21 is formed in the protruding cylinder 20 in a direction orthogonal to the first surface 31. As shown in FIGS. 3 and 4, the first hole 21 is a hole into which one end of the capillary 40 is inserted and temporarily fixed. As the capillary 40, one having an external dimension of, for example, 0.8 to 2.0 mm and a capacity of, for example, 10 to 30 μL can be used.

A first space 22 is continuously formed at the end of the first hole 21. The first hole 21 and the first space 22 form the first passage 70. A second hole 23 is formed inward from the second surface 32 of the main body block 30. The second hole 23 is formed in a tapered shape from its entrance to the inside. A second space 25 is formed behind the second hole 23. The second hole 23 and the second space 25 form a second passage 80.

The first passage 70 communicates with the second passage 80. As shown in FIG. 5, a line L1 (first line) extending in the longitudinal direction in the center of the first passage 70 composed of the first hole 21 and the first space 22 and the second line. The angle formed by the line L2 (second line) extending in the longitudinal direction in the center of the second passage 80 composed of the hole 23 and the second space 25 is 90 degrees. This angle is allowed to be 90 degrees to 90 degrees ± 10 degrees. Further, in the present embodiment, the plane including the line L1 and the line L2 is a plane orthogonal to the first surface 31 and the second surface 32, and stands vertically from the bottom surface of the main body block 30. However, the plane including the line L1 and the line L2 stands at an angle of 90 degrees from the bottom surface of the main body block 30 to the left and right (the side of the knob portion 11 or the opposite side of the knob portion 11) in a range of 10 degrees. It may be in a state of being.

The second hole 23 functions as a port into which a suction tube for sucking the liquid collected by the capillary 40 is inserted. The first surface 31 and the second surface 32 are adjacent surfaces at the base 10, and are orthogonal to each other. As shown in FIG. 5, from the second surface 32 orthogonal to the first surface 31, the main body block 30 is directed in the direction in which the second hole 23 is orthogonal to the second surface 32. Formed within. The second space 25 is formed in the main body block 30 so as to communicate with the second hole 23. Further, as shown in FIG. 6, the diameter of the second space 25 communicating with the second hole 23 is set to be smaller than the minimum diameter of the second hole 23. The diameter of the second space 25 is smaller than the diameter of the tip of the suction tube 50 in the measuring device, and the insertion of the suction tube 50 is suppressed in the second space 25.

As shown in FIGS. 2 and 4, a step 24 is formed at the boundary between the peripheral wall of the first hole 21 and the peripheral wall of the first space 22, and the diameter of the first space 22 is the diameter of the first hole 21. The diameter is smaller than the diameter. The diameter of the first hole 21 is formed to be substantially the same as the outer diameter of the capillary 40 from the entrance of the first hole 21 to just before the first space 22. The step 24 functions as a stopper when the capillary 40 is inserted into the first hole 21.

When assembling the trace liquid sampling device 200 shown in FIG. 3 using the adapter 100, the assembly jig 60 shown in FIGS. 7 and 8 can be used. The assembly jig 60 has a groove portion 62 for positioning and arranging the capillary 40 on the base plate 61. Further, the assembly jig 60 is provided with an arrangement table 63 for arranging the adapter 100 at an optimum position for assembly with respect to the capillary 40 arranged in the groove portion 62.

In the base plate 61, a stopper plate 64 for stopping the movement of the capillary 40 in the longitudinal direction is erected at a position on one end side of the groove portion 62 in the direction opposite to the arrangement table 63. A pair of holding portions 65, 65 sandwiched in order to position the projecting cylinder 20 with respect to the capillary 40 set in the groove portion 62 at a position facing the placement table 63 on the other end side in the longitudinal direction of the groove portion 62. It is provided.

A sliding plate 66 is erected on one side of the arrangement table 63. The sliding 66 serves as a guide when the adapter 100 is arranged on the arrangement table 63 and pushed in the direction of the capillary 40 set in the groove 62 to slide the adapter 100. Further, stoppers 67 and 67 are provided at positions separated by a predetermined dimension from the pair of holding portions 65 and 65 toward the groove portion 62. The stoppers 67 and 67 have a function of stopping the capillary 40 at an appropriate position when the capillary 40 is inserted into the first hole 21 of the projecting cylinder 20 in the adapter 100 by sliding using the sliding plate 66.

The procedure for assembling the trace liquid sampling device 200 using the assembly jig 60 having the above configuration will be described below. A capillary 40 is inserted into the groove 62 of the assembly jig 60, and the capillary 40 is pressed against the stopper plate 64 to be brought into contact with the stopper plate 64 (FIGS. 8 and 9).

Next, the adapter 100 is brought closer to the placement table 63 from the protruding cylinder 20 side and set on the placement table 63 (FIG. 10). Next, a predetermined surface of the base 10 is slid on the sliding plate 66, and the adapter 100 is pressed in the direction of the capillary 40. The above pressing is continued until the movement of the adapter 100 is stopped by the stoppers 67 and 67, and the capillary 40 is inserted into the first hole 21 in the protruding cylinder 20 of the adapter 100 to complete the temporarily fixed trace liquid collection device 200. (Fig. 11).

In the completed trace liquid sampling device 200, since one end of the capillary 40 abuts on the step 24, no further insertion is made and the device does not enter the first space 22. Therefore, when the suction tube 50 of the measuring device is inserted from the second hole 23 side, the capillary 40 does not exist in the first space 22 to which the tip end portion of the suction tube 50 faces, and the tip end portion of the suction tube 50 The suction tube 50 can appropriately suck the liquid to be inspected by the suction tube 50 without damaging the capillary 40 or pushing the capillary 40 out of the protruding cylinder 20.

As described above, the diameter of the second space 25 is smaller than the diameter of the tip of the suction tube 50 in the measuring device, and the insertion of the suction tube 50 is suppressed in the second space 25. Therefore, the tip of the suction tube 50 does not go beyond the second space 25 and come into contact with the bottom, and the tip of the suction tube 50 is damaged or the tip of the suction tube 50 is separated from the first space 22. The liquid to be inspected such as blood can be appropriately sucked by the suction tube 50 without blocking the passage leading to the space 25 of 2.

When using the completed trace liquid collection device 200, the operator holds the knob portion 11 between his thumb and index finger, and puts the tip 41 of the capillary 40 into a liquid to be inspected such as blood. At this time, it is preferable that the capillary 40 is in a state close to horizontal. Then, due to the capillary phenomenon, the liquid to be inspected enters the capillary 40 and can be collected.

Further, in a state where the liquid to be inspected has entered the capillary 40, hold the knob portion 11 between the thumb and the index finger to keep the capillary 40 in a nearly horizontal state, and turn the opening of the second hole upward. The adapter 100 can be moved directly below the tip of the suction tube 50 in the measuring device. Therefore, the risk of the liquid falling from the inside of the capillary 40 by its own weight can be reduced. By such an action, a larger amount of liquid can be held in the trace liquid sampling device 200, and a decrease in measurement accuracy due to a small amount of liquid for analysis can be prevented. In addition, it is expected that the number of measurement items will increase because the amount of liquid at the time of sampling can be secured almost as it is.

In the above embodiment, the main body block 30 is provided with a base portion 10 and a projecting cylinder 20 protruding outward from the first surface 31 of the base portion 10. However, the main body block 30 may be a block in which a capillary is attached and a port for providing a port for sucking the liquid collected by the capillary is provided, and the main body block 30 may be a block having a protruding portion such as a protruding cylinder 20. It is not necessary to prepare. Further, the base portion 10 is separately provided with a knob portion 11 protruding from the right side wall surface thereof, for example, but if the base portion 10 itself has a size and shape having the function of the knob portion 11, the knob portion 11 is separately provided. It doesn't have to be.

In the adapter of the trace liquid sampling device according to the present invention, a step is formed at the boundary between the peripheral wall of the first hole and the peripheral wall of the first space, and the diameter of the first space is the first hole. The diameter may be smaller than the diameter of.

In the adapter of the trace liquid sampling device according to the present invention, the second hole is formed in a tapered shape from the inlet to the inside, and the diameter of the second space is smaller than the minimum diameter of the second hole. May be said.

In the adapter of the trace liquid sampling device according to the present invention, the second space, the base having the shape of the second passage 80, and the first hole are formed, and the adapter is outside the first surface of the base. It may be provided with a projecting cylinder protruding toward the direction.

10 Base 11 Knob 20 Overhanging cylinder 21 First hole 22 First space 23 Second hole 24 Step 25 Second space 30 Main body block 31 First surface 32 Second surface 40 Capillary 41 Tip 50 Suction Tube 60 Assembly jig 61 Base plate 62 Groove 63 Arrangement stand 64 Stopper plate 65 Holding part 66 Sliding plate 67 Stopper 70 First passage 80 Second passage 100 Adapter 200 Trace liquid sampling device

Claims (5)

A first passage having a first hole into which one end of the capillary for collecting the liquid to be inspected is inserted, and the insertion temporarily fixing the capillary , and a first space following the first hole. ,
A second hole into which a suction tube for sucking the liquid collected by the capillary is inserted and a second space communicating with the second hole, and communicating with the first passage. The passage and
Have,
The angle between the first line extending in the longitudinal direction in the center of the first passage and the second line extending in the longitudinal direction in the center of the second passage is 90 degrees to 90 degrees ± 10 degrees. Adapter for trace liquid collection equipment. A step is formed at the boundary between the peripheral wall of the first hole and the peripheral wall of the first space.
The adapter for a trace liquid sampling device according to claim 1, wherein the diameter of the first space is smaller than the diameter of the first hole. The second hole according to claim 1 or 2, wherein the second hole is formed in a taper shape from the inlet to the inside, and the diameter of the second space is smaller than the minimum diameter of the second hole. Adapter for trace liquid collection equipment. The second space, the base having the shape of the second passage, and
The adapter for a trace liquid collection device according to any one of claims 1 to 3, wherein the first hole is formed and the protruding cylinder body is provided so as to project outward from the first surface of the base. A first passage having a first hole into which one end of the capillary for collecting the liquid to be inspected is inserted and the insertion temporarily fixing the capillary , and a first space following the first hole. , A second hole into which a suction tube for sucking the liquid collected by the capillary is inserted, a second space communicating with the second hole, and a second passage communicating with the first passage. The angle between the first line extending in the longitudinal direction in the center of the first passage and the second line extending in the longitudinal direction in the center of the second passage is 90 degrees to 90 degrees ±. The adapter for the trace liquid collection device, which is said to be 10 degrees, and
A trace liquid sampling device including a capillary inserted in the first hole.

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