JP6978255B2 - Liquid discharge device and measuring tape - Google Patents

Description

The present invention relates to a liquid discharge device and a measuring tape.

Conventionally, after surgery or the like, drainage is performed in which a liquid or gas stored in a patient's body is discharged to the outside of the body. Regarding this drainage, there is a device that samples the liquid in the body in order to analyze the liquid stored in the body.

As a device for sampling a liquid, Patent Document 1 discloses a dispensing device having a sample suction mechanism by a roller method. This dispensing device moves the liquid container containing the sample, lowers the tube nozzle, puts the tip of the tube into the sample, and then causes suction. At this time, the tube squeezing roller is rotated to the suction side by a desired suction set amount. The tube is moved and restored so that the portion sandwiched and compressed by the tube squeezing roller is sequentially released, and the inside of the tube is decompressed to suck up serum.

Further, Patent Document 2 discloses a container for preparing a blood component for collecting a predetermined amount of blood. This blood component preparation container is slidably arranged on the inner peripheral surface of the outer cylinder, and the partition member that divides the outer cylinder into a fluid storage chamber and a gas inlet / outlet chamber slides by magnetic force to move blood. .. The blood collected through the voting tube due to the sliding of the partition member is aseptically stored in the fluid storage chamber. The serum prepared in the fluid storage chamber is led out to the component storage container via the connecting tube.

Further, Patent Document 3 discloses a liquid sampling system in which a liquid to be measured is separated and sampled in chronological order. This liquid sampling system is provided in the middle of the flow path through which the liquid to be measured flows, and by inserting a liquid different from the liquid to be measured as a separator, the liquid to be measured is separated and taken out in chronological order.

Japanese Unexamined Patent Publication No. 7-260640 Japanese Unexamined Patent Publication No. 2009-95657 Japanese Patent No. 5564489

The dispensing device described in Patent Document 1 has quantitativeness and continuity, but is a large device and is difficult to carry. That is, it is insufficient for miniaturization and portability. The container for preparing blood components described in Patent Document 2 has quantitativeness and portability, but blood is collected by sliding the partition member, so that liquid remains in a secondary path such as a voting tube or a connecting tube. Was a concern. The liquid sampling system described in Patent Document 3 has quantitativeness and continuity, but is a large-scale device, difficult to carry, and insufficient in miniaturization and portability.

The present invention has been made in view of the above circumstances, and provides a liquid discharge device and a measuring tape which are excellent in portability and can suppress the liquid from remaining in the flow path after sampling.

One aspect of the present invention is a liquid discharge device for discharging a liquid, which comprises a main flow path, a sub flow path branched from the main flow path, a range between two points in the main flow path, and an outside of the range. Two limiting members that restrict the flow of the liquid between them, and a first pressing member that presses the main flow path between the two points in a state where the flow of the liquid is restricted in the main flow path. The sub-flow path allows the liquid from the main flow path to pass when pressed by the first pressing member, and does not allow the liquid from the main flow path to pass when not pressed by the first pressing member. , A liquid discharge device.

One aspect of the present invention includes a blood cell separation membrane that separates the blood cells and the non-blood cells from the drainage containing blood cells and non-blood cells discharged from the living body, and the non-blood cells separated by the blood cell separation membrane. It is a measuring tape having an enzyme reaction sheet that reacts with the enzyme, and a spacer having an opening and arranged between the blood cell separation membrane and the enzyme reaction sheet.

According to the present invention, the portability is excellent, and it is possible to prevent the liquid from remaining in the flow path after sampling.

The figure which shows the schematic structure of the drain drainage management system in embodiment The figure which shows the internal structure of a drain drainage sensor Block diagram showing the circuit configuration of the sensor unit Diagram showing the shape of the drain bag Partially broken perspective view showing the appearance of the drain drainage monitor The figure explaining the operation of the drainage sampling mechanism Flow chart showing drainage sampling operation procedure As the first verification result, a graph showing the measurement result of the weight per sampling when distilled water is used. Table showing sampling results The figure which shows the schematic structure of the drainage sampling mechanism As a second verification result, a graph showing the measurement result of the weight per sampling when the sampling amount is adjusted and distilled water is used. Table showing sampling results The figure explaining the preparation of the tissue pulverized solution of a mouse. Enlarged view showing the vicinity of the branch point of the main tube when the sub tube does not have an opening. Enlarged view showing the vicinity of the branch point of the main tube when the sub tube has an opening A graph showing the measurement result of the weight per sampling when the subtube has an opening and when it does not have an opening. Mean [g], standard deviation, C.I. Table showing V value [%] Cross-sectional view showing the structure of the measuring tape The figure explaining the state of performing the blood cell separation and the enzyme reaction using the measuring tape. The figure explaining the state of performing the blood cell separation / enzyme reaction using the measuring tape following FIG. 12B. A table showing the characteristics of various materials used for blood cell separation membranes The figure explaining the method of permeating the tissue pulverized solution along the surface of the blood cell separation membrane and separating blood cells. Graph showing the correlation between the change in absorbance due to membrane separation and the change in absorbance due to centrifugation Diagram illustrating a standard method for measuring amylase activity The figure explaining the osmotic filtration method for measuring the amylase activity. Diagram illustrating a transcription method for measuring amylase activity Graph showing the measurement result of amylase activity by the standard method Graph showing the measurement result of amylase activity by osmotic filtration method Graph showing the measurement result of amylase activity by transcription method Flow chart showing the procedure for measuring amylase activity The figure which shows the display of the drain drainage monitor Cross-sectional view showing the structure of the measuring tape The figure explaining the measurement method of bilirubin using a spectrophotometer The figure explaining the measurement method of bilirubin using membrane measurement Graph showing the measurement result of bilirubin when using the standard method Graph showing the measurement result of bilirubin when membrane measurement is used The figure which shows the structure of the measuring tape which can measure the state of both amylase and bilirubin. Perspective view showing a structural example of the third pressing member AA sectional view showing an example of the state of the third pressing member and the main tube in the state α of the third pressing member. AA sectional view showing an example of the state of the third pressing member and the main tube in the state β of the third pressing member. AA sectional view showing an example of the state of the third pressing member and the main tube in the state γ of the third pressing member. The figure explaining that the biological fluid containing a drug or the like is introduced into patient PA1 by the TCI pump 10A.

Hereinafter, embodiments of the liquid discharge device and the measuring tape according to the present invention will be described with reference to the drawings. In this embodiment, a drain drainage management system including a liquid discharge device and a measuring tape is shown. The drainage drainage management system measures the state of the controlled component contained in the drainage drainage flowing through the drainage tube connected to the patient's body, and observes and evaluates the state of the drainage drainage in various ways.

Drain drainage is a liquid containing blood, exudate, etc. accumulated in the body, which is discharged to the outside of the body after surgery. When gastrointestinal surgery is performed, the digestive enzyme amylase and the bile pigment bilirubin may come out of the affected area. These components can damage organs and dissolve blood vessels, which can lead to bleeding and can be a risk of complications. Therefore, measuring the state of the controlled component contained in the drainage fluid is a great index for the medical staff to consider the next medical practice. As a controlled component in drainage, for example, measurement of amylase, bilirubin, and blood status can be considered.

(Configuration of drainage drainage management system)
FIG. 1 is a diagram showing a schematic configuration of a drainage drainage management system 5 according to an embodiment. The drain drainage management system 5 includes a non-contact type drain drainage sensor 10, a drain drainage monitor 20, a drain tube 30, and a drain bag 40. The drainage sensor 10 is used to measure the state of a controlled component (eg, blood, amylase, bilirubin), which is a controlled component in the drain drain flowing through the transparent drain tube 30. That is, the drain drainage sensor 10 is an example of a measuring device. As a controlled ingredient, amylase is a digestive enzyme secreted by the pancreas and salivary glands. Bilirubin is a yellow pigment component contained in bile. Blood is bleeding from organs and blood vessels.

The drain drainage monitor 20 is connected to the drain drainage sensor 10 by wireless communication or wired communication, and records and displays the measurement result by the drain drainage sensor 10. A display 21 for displaying various information is arranged on the front surface of the drain drainage monitor 20.

The drain tube 30 circulates the drain drainage discharged from the patient's body and flows it into the drain bag 40. The drain tube 30 is formed of a material such as a translucent resin so that the user can visually observe the drainage drainage. One end of the drain tube 30 is connected (inserted) to the patient's body, and the other end of the drain tube 30 is connected to the drain bag 40. The drain bag 40 stores the drain drainage fluid that has flowed in from the drain tube 30.

The drain drainage stored in the drain bag 40 includes the drainage that has flowed in from the start of drainage to the time of measurement. Therefore, it is difficult to measure the state of the controlled component in the drainage drainage, which fluctuates with the passage of time, in association with time using the drainage drainage.

Therefore, in the drain drainage management system 5, the state of the controlled component in the drain drainage is measured by using the drain drainage flowing through the drain tube 30 connected between the patient's body and the drain bag 40. It was to be. By this method, the drainage drainage management system 5 can measure the patient non-invasively.

FIG. 2A is a diagram showing an internal configuration of the drain drainage sensor 10. The drain drainage sensor 10 has, for example, a box-shaped housing 10z, and houses the drainage sampling mechanism 110 and the blood cell separation / enzyme reaction mechanism 150 inside the housing 10z.

In the drainage sampling mechanism 110, a main tube 130 (an example of a main flow path) is attached so as to penetrate the inside of the housing 10z. In FIG. 2A, the main tube 130 is provided in the left-right direction. Both ends of the main tube 130 may protrude from the through holes 10y formed on both side surfaces of the housing 10z and may be connected to both ends of the drain tube 30. The main tube 130 may be a part of the drain tube 30.

A sub tube 133 (an example of a sub flow path) branching from the main tube 130 is connected to substantially the center of the main tube 130. Here, the position of the main tube 130 to which one end of the sub tube 133 is connected is also referred to as a branch point. The sub tube 133 has an elongated flow path 133z that can communicate with the inside of the main tube 130. The branch point may be a connection position between the sub tube 133 and the flow path 133z. The sub-tube 133 may be formed of an elastic material (rubber, resin, etc.) and may be a material that recovers elasticity. The sub-tube 133 is deformed within the range of elastic deformation and is not deformed within the range of plastic deformation. The elongated flow path 133z is normally closed. Since the flow path 133z is normally closed, the drain drainage Lq in the main tube 130 does not flow into the flow path 133z of the sub tube 133, and the liquid in the flow path 133z of the sub tube 133 does not flow into the main tube 130. There is no backflow to. Further, gas does not flow in from the side of the sub tube 133 opposite to the main tube 130 side (lower side of FIG. 2S).

When viewed from the main tube 130, the sub tube 133 can be said to be a protruding portion formed in the middle of the main tube 130. It can be said that a notch is formed in this protrusion as a flow path 133z.

The drainage sampling mechanism 110 includes a pair of limiting members 113 and 114, and a first pressing member 115, in addition to the main tube 130 and the sub tube 133.

The pair of limiting members 113, 114 have a partition plate 113B, 114B formed by bending the tip thereof, and a pressure unit 113A, 114A, respectively. The partition plates 113B and 114B driven by the pressurizing units 113A and 114A move so as to press the points on both sides (for example, two points) sandwiching the branch point of the main tube 130, respectively. The pair of limiting members 113 and 114 can freely press the locations on both sides of the main tube 130 that sandwich the branch point of the sub tube 133. When the pair of limiting members 113 and 114 press the locations on both sides of the main tube 130 substantially at the same time, the drain drainage Lq is restricted to the main tube 130, for example, it does not flow. Therefore, the drain drainage Lq stays in the central portion 130c of the main tube 130 located near the branch point. The central portion 130c of the pipe may be, for example, a region between two points pressed by the limiting members 113 and 114.

The first pressing member 115 has a pressing plate 115B having a flat plate along the longitudinal direction of the main tube 130, and a pressing unit 115A. The pressing plate 115B driven by the pressurizing unit 115A moves so as to press the main tube 130. When the first pressing member 115 presses the main tube 130, the pressure of the drain drainage Lq that stays in the tube central portion 130c of the main tube 130, which is closed by the pair of limiting members 113 and 114, increases.

When the pressure of the drain drainage Lq in the central portion 130c of the pipe rises, the flow path 133z of the sub tube 133 opens, and the drainage drainage Lq staying in the central portion 130c of the pipe flows into the flow path 133z of the sub tube 133. .. The drainage that has flowed into the flow path 133z of the sub tube 133 flows out so as to be pushed out from the end face on the opposite side of the flow path 133z. The drain drainage Lq flowing out from the end face on the opposite side of the flow path 133z is dropped onto the measuring tape 200 arranged so as to face the sub tube 133 as the sampling liquid sq (see FIG. 12B).

The pressurizing units 113A, 114A, 115A, 116A (described later) move the partition plates 113B, 114B, the pressing plate 115B, and the tip portion 116B in the advancing / retreating direction according to the drive signal from the sensor unit 180, respectively. For example, when the pressurizing unit is composed of a motor gear mechanism, the partition plates 113B and 114B, the pressing plate 115B, and the tip portion 116B move linearly by driving the motor. The pressurizing unit is not limited to the motor gear mechanism, and may be composed of an electromagnetic slide mechanism, a piezoelectric element, a hydraulic slide mechanism, or the like.

The blood cell separation / enzyme reaction mechanism 150 separates blood cells contained in the drain drainage Lq, reacts the enzyme with the reagent, and optically measures the absorbance of the enzyme. The blood cell separation / enzyme reaction mechanism 150 may optically measure the absorbance of controlled components other than the enzyme (for example, blood cells and bilirubin). The blood cell separation / enzyme reaction mechanism 150 includes a second pressing member 116, a tape winding feeding mechanism 170, and a sensor unit 180.

The second pressing member 116 has, for example, a tip portion 116B having a rounded tip and a pressure unit 116A. The tip portion 116B driven by the pressurizing unit 116A advances and retreats so as to press the measuring tape 200. By pressing the measuring tape 200, the reaction between the enzyme and the reagent contained in the sampling liquid sq dropped on the measuring tape 200 may be carried out. The details of the operation of reacting the enzyme with the reagent using the measuring tape 200 will be described later.

The tape take-up feed mechanism 170 includes a measurement tape 200 on which the sampling liquid sq is dropped, a feed reel 171 on which an unused measurement tape 200 is wound, and a take-up reel on which the measurement tape 200 after the reaction is wound. Has 172. Further, the tape take-up feed mechanism 170 has a motor 175 for driving the take-up reel 172 and rollers 177 and 176 for guiding the movement of the measurement tape 200. The take-up reel 172 is rotated by the drive of the motor 175, and takes up the measurement tape 200 after the reaction. The feed reel 171 is rotated by the movement of the measuring tape 200.

Here, the take-up reel 172 rotates so as to take up the measurement tape, but each of the take-up reel 172 and the feed reel 171 is driven by a motor to simultaneously take up and feed the measurement tape 200. It may be possible to make the movement of the measuring tape 200 more stable. Further, only the feed reel 171 may be driven by a motor, and the take-up reel 172 may be rotated around.

The sensor unit 180 is arranged so as to face the drainage sampling mechanism 110 with the measuring tape 200 interposed therebetween. The sensor unit 180 optically measures the absorbance of the enzyme contained in the sampling liquid sq2 (see FIG. 12B) permeated into the measuring tape 200 sent out by the tape winding feeding mechanism 170. In this measurement, the sensor unit 180 projects light having a peak value of a predetermined wavelength (for example, a wavelength of 410 nm) as measurement light toward the measurement tape 200 permeated with the sampling solution sq2 containing a large amount of enzyme. The sensor unit 180 may receive the scattered light that is not absorbed by the enzyme in the sampling solution sq2, and may measure the absorbance of the enzyme contained in the sampling solution sq2 based on the received amount of the scattered light.

FIG. 2B is a block diagram showing a circuit configuration of the sensor unit 180. The sensor unit 180 has a housing 180z in which the circuit board 188 is laid inside. The sensor unit 180 includes a CPU (Central Processing Unit) 181, an LED (Light Emitting Diode) 182, a photo sensor (PD) 183, a wireless chip 184, and a battery 185. The CPU 181 and the photo sensor 183, and the LED 182 are mounted on the circuit board 188.

The CPU 181 controls the operation of each part in the sensor unit 180. The CPU 181 may perform various arithmetic processes such as calculating the absorbance based on the amount of light received from the photo sensor 183. The CPU 181 includes functions as a pressurizing unit drive unit 186 and a motor drive unit 187. The pressurizing unit drive unit 186 outputs drive signals to the pressurizing units 113A, 114A, 115A, and 116A, respectively. The motor drive unit 187 outputs a drive signal to the motor 175 that rotates the take-up reel 172. The CPU 181 has a time measuring function, and may measure a time at the time of sampling or a time at the time of measurement.

The CPU 181 generates measurement data (an example of the first information) such as absorbance. The measured data is data on controlled components (eg, blood, amylase, bilirubin). The measurement data may be managed in association with the time when the measurement data was measured. The measurement data may include, for example, information on the absorbance of the controlled component and the amount of change in the absorbance. The measurement data may include information on the emissions of controlled components per hour. The measurement data may include information on the total emissions of controlled components. The amount of the controlled component discharged may be the amount of the controlled component flowing through the main tube 130, or the amount of the controlled component sampled via the sub tube 133 (sampling amount). good.

The LED 182 emits light having a peak value of a predetermined wavelength (for example, a wavelength of 410 nm) as measurement light. The photo sensor 183 receives light scattered without being absorbed by a controlled component such as amylase, and outputs a signal according to the amount of received light.

The wireless chip 184 wirelessly communicates with the drain drainage monitor 20 and transmits various data measured by the sensor unit 180 to the drain drainage monitor 20. For wireless communication, communication such as short-range wireless communication (Bluetooth (registered trademark), ZigBee (registered trademark), etc.) or wireless LAN (Local Area Network) can be used. The battery 185 supplies electric power to each part of the sensor unit 180. The battery 185 may be a secondary battery such as a rechargeable lithium ion battery or a primary battery such as an alkaline battery.

FIG. 3 is a diagram showing the shape of the drain bag 40. The drain bag 40 is a bag for storing drainage fluid. An inflow tube 41 through which drainage drainage flows is attached to the drain bag 40. The tip of the inflow tube 41 is connected to one end of the drain tube 30. The inflow tube 41 may be a part of the drain tube 30. The drain drainage fluid flowing out of the drain tube 30 flows into and is stored in the drain bag 40. Further, since the inside of the drain bag 40 is held under negative pressure, even if the tip of the inflow tube 41 is connected to one end of the drain tube 30, the drain drainage stored in the drain bag 40 does not flow back to the drain tube 30. .. In addition, by being maintained under negative pressure, it also prevents infection in patients who drain drainage.

Here, the main tube 130 is connected to the drain tube 30, and the sub tube 133 branches from the main tube 130. A flow path 133z is formed in the sub tube 133 in order to sample and extract the drain drainage Lq. However, in the sub tube 133, the flow path 133z is basically closed when the drain drainage Lq does not pass through. Therefore, the sub tube 133 can prevent air or the like from entering the main tube 130 side (drain tube 30 side) from the flow path 133z. Therefore, even if the drain drainage sensor 10 includes the main tube 130 and the sub tube 133, it is possible to suppress the ingress of air or the like from the sub tube 133 and maintain the negative pressure of the drain bag 40. Therefore, it is possible to prevent the drain drainage liquid stored in the drain bag 40 from flowing back into the drain tube 30. It was confirmed that almost no gas such as air was mixed in the drain bag 40 even after one week with the drain drain sensor 10, the drain tube 30, and the drain bag 40 connected. ..

FIG. 4 is a partially broken perspective view showing the appearance of the drain drainage monitor 20. The drain drainage monitor 20 has a box-shaped housing 20z. A display 21 is arranged on the front surface of the housing 20z. The display 21 notifies the graph 22 showing the measurement result over time, various explanatory texts 23 such as the patient's name, the meter 24 showing the current value of the measurement result, and the patient's condition (normal / abnormal). The status marker 25 and the like for the purpose are displayed.

The drain drainage monitor 20 is wirelessly communicated with a CPU 26 that performs various controls of the drain drainage monitor 20, a memory 27 that records measurement data of the drain drainage sensor 10, and a wireless chip 184 of the drain drainage sensor 10. A wireless chip 28 for performing the above is provided.

Further, the drain drainage monitor 20 has a built-in internal clock (not shown), and the measurement data measured by the drain drainage sensor 10 (specifically, the sensor unit 180) and the time when the measurement data are measured. And are associated with each other and recorded in the memory 27. The measurement data may include information on the emissions of controlled components per hour. The information on the amount of the controlled component discharged per unit time of the drainage Lq includes, for example, the information on the absorbance of the controlled component (for example, amylase, bilirubin, blood) and the amount of change in the absorbance per unit time. good. The graph 22 is displayed so as to represent the change with time of the measurement result based on the time series data (an example of the second information) recorded in the memory 27. Further, the measurement data may be information on the total emission amount of the controlled component.

The CPU 26 may register (retain) a part or all of the time-series data recorded in the memory 27 and at least one of the display results of the graph 22 in the electronic medical record for each patient. The electronic medical record may be stored in the memory 27, or may be stored in a server (not shown) different from the drain drainage monitor 20. When the electronic medical record is stored in the server, the drain drainage monitor 20 may be configured to be able to register in the electronic medical record and browse the electronic medical record by communicating with the server by the wireless chip 28.

(Operation of drainage sampling mechanism)
The details of the operation of the drainage sampling mechanism 110 will be described. FIG. 5 is a diagram illustrating the operation of the drainage sampling mechanism 110. In the non-pressure state (state A) in which the main tube 130 is not pressed, a liquid (for example, drain drainage, distilled water) flows in the tube of the main tube 130.

First, the limiting members 113 and 114 press the main tube 130 at substantially the same time to limit the flow of the liquid (state B). The inside of the pipes on both sides of the main tube 130 sandwiching the branch point, that is, the central portion 130c of the pipe is closed by the partition plates 113B and 114B (see state B in FIG. 5). This limits the flow of liquid inside and outside the central portion 130c of the pipe. The liquid may flow slightly without being completely blocked. A certain amount of liquid stays in the central portion 130c of the pipe and between the limiting members 113 and 114. In the state B, the flow path 133z of the sub tube 133 is closed, and the flow path 133z does not allow the liquid to pass through.

The limiting members 113 and 114 press the main tube 130 substantially at the same time, and the first pressing member 115 presses the tube center portion 130c of the main tube 130 in a state where the liquid stays in the tube center portion 130c of the main tube 130 (. State C). When the tube center portion 130c is pressed, the pressure of the liquid staying in the tube center portion 130c of the main tube 130 increases. The increase in the pressure of this liquid expands the flow path 133z of the sub tube 133 connected to the main tube 130 at the branch point. The liquid staying in the central portion 130c of the main tube 130 flows into the flow path 133z of the sub tube 133 and flows out from the opposite end surface of the sub tube 133. When almost all the liquid flows out, the central portion 130c of the main tube 130 becomes recessed. As a result, a certain amount of liquid that has accumulated between the limiting members 113 and 114 can be delivered via the sub tube 133. Therefore, in the state C, the flow path 133z of the sub tube 133 is opened, and the flow path 133z allows the liquid to pass through.

In a state where the first pressing member 115 presses the tube central portion 130c of the main tube 130, the limiting members 113 and 114 stop pressing and remove both side portions (two locations) sandwiching the branch point of the main tube 130. Press (state D). Further, when the first pressing member 115 releases the pressing of the tube central portion 130c, the main tube 130 returns to the state A and becomes a non-pressure state. By changing to the state A following the state D, it is possible to suppress the backflow of the liquid from the sub tube 133 to the main tube 13 due to the decrease in the pressure in the tube central portion 130c.

Further, by further changing to the state B after the state A, a new fixed amount of the liquid circulating in the main tube 130 can be retained and secured.

By repeating the states A to D, the drainage sampling operation can be continuously performed, and a certain amount of liquid can be extracted. The drainage sampling operation by the drainage sampling mechanism 110 is not limited to the drain drainage Lq, and can be applied to various liquids as a liquid sampling operation by the liquid sampling mechanism.

FIG. 6 is a flowchart showing a drainage sampling operation procedure by the drain drainage sensor 10. The CPU 181 waits until the sampling time comes (S1). The sampling time is set to an appropriate time, for example, once an hour. At the sampling time, the CPU 181 outputs a drive signal to the pressurizing units 113A and 114A, and starts pressing by the limiting members 113 and 114 (S2). When the portions on both sides of the main tube 130 sandwiching the branch point are pressed by the limiting members 113 and 114, the tube central portion 130c of the main tube 130 is closed by the partition plates 113B and 114B. Liquid stays in the central portion 130c of the main tube 130.

While maintaining the pressing by the limiting members 113 and 114, the CPU 181 outputs a drive signal to the pressurizing unit 115A and starts pressing by the first pressing member 115 (S3). When the tube center portion 130c of the main tube 130 is pressed, the pressure of the liquid staying in the tube center portion 130c increases. The increase in the pressure of this liquid expands the flow path 133z of the sub tube 133. The liquid staying in the central portion 130c of the main tube 130 passes through the flow path 133z of the sub tube 133 and flows out from the end surface on the opposite side of the flow path 133z. When almost all the liquid flows out, the central portion 130c of the main tube 130 becomes recessed.

The CPU 181 outputs a drive signal to the pressurizing unit 115A, stops the drive signal to the pressurizing units 113A and 114A while maintaining the pressing operation by the first pressing member 115, and depressurizes by the limiting members 113 and 114. Is started (S4). Even if the depressurization is performed by the limiting members 113 and 114, the state in which the central portion 130c of the main tube 130 is recessed is maintained.

The CPU 181 stops the drive signal to the pressurizing unit 115A and starts depressurizing by the first pressing member 115 (S5). When the depressurizing operation is performed by the first pressing member 115, the pressure-free state is restored, and the liquid flows through the tube center portion 130c of the main tube 130. The direction in which the liquid flows is from the patient side toward the drain bag 40.

According to such an operation procedure of drainage sampling, the drain drainage management system 5 can control the states A to D and easily transition the states from state A to state D. As a result, the drainage drainage management system 5 can sample the drainage drainage quantitatively and continuously.

(Verification of drainage sampling operation)
Next, the first verification result of the drainage sampling operation by the drainage sampling mechanism 110 is shown. In the first verification operation, first, distilled water was used instead of the drain drainage Lq, and the drainage sampling operation was repeated to examine the change in the sampling amount. FIG. 7A is a graph showing the measurement result of the weight per sampling when distilled water is used as the first verification result. The vertical axis of the graph shows the sampling amount (g), and the horizontal axis shows the number of samplings. In the case of distilled water, 1 g corresponds to 1 ml (milliliter). The graph shows the case where distilled water is sampled 16 times. The sampling amount is within the range of 0.3 g to 0.6 g. FIG. 7B is a table showing sampling results. In this table, mean: 0.46 g, standard deviation: 0.07, C.I. V (coefficient of variation): 15.8% is shown.

From the first verification result, it can be understood that when distilled water is used, the drainage sampling mechanism 110 stabilizes the sampling amount to a constant amount (has quantitativeness) and enables continuous sampling.

Subsequently, the second verification result of the drainage sampling operation in the drainage sampling mechanism 110 is shown. In the second verification operation, as in the first verification operation, distilled water was used, the sampling amount was set in three ways, the drainage sampling operation was repeated, and the change in the sampling amount was examined.

FIG. 8A is a diagram showing a schematic configuration of the drainage sampling mechanism 110. The amount of sampling was adjusted by changing the content of the central portion 130c of the main tube 130. That is, by changing the distance (distance) L between the limiting members 113 and 114, the internal volume of the drain drainage or the like in the central portion 130c of the main tube 130 is changed. The interval L may be set in the range of 10 mm to 50 mm. Further, the length of the pressing plate 115B of the first pressing member 115 may be adjusted to be equal to the length of the interval L so that the central portion 130c of the pipe can be pressed uniformly.

FIG. 8B is a graph showing the measurement result of the weight for each sampling when the sampling amount is adjusted and distilled water is used as the second verification result. The vertical axis of the graph shows the sampling amount (g), and the horizontal axis shows the number of samplings. Graph g11 shows the change in the sampling amount when the interval L is 50 mm. The graph g12 shows the change in the sampling amount when the interval L is 24 mm. The graph g13 shows the change in the sampling amount when the interval L is 20 mm.

FIG. 8C is a table showing sampling results. In this table, when the interval L is 50 mm, the average value: 0.48 g, the standard deviation: 0.02, C.I. V: 5.2% is shown. When the interval L is 24 mm, the average value: 0.22 g, the standard deviation: 0.033, and C.I. V: 15.2% is shown. When the interval L is 20 mm, the average value: 0.55 g, the standard deviation: 0.0065, and C.I. V: 12.0% is shown.

According to the second verification result, when distilled water is used, the drainage sampling mechanism 110 stabilizes the sampling amount to a constant amount (has quantitativeness) regardless of the sampling amount, and can continuously sample. Can be understood. Further, it can be understood that stable sampling operation is possible even with a sampling amount of 100 μliters (0.1 g in the case of distilled water) or less.

(Consideration of pressure in drainage sampling operation)
Next, the force applied to the flow path 133z of the sub tube 133 when performing the drainage sampling operation will be considered. When sampling the liquid flowing through the main tube 130, it is necessary to satisfy the equation (1) as a sampling condition.
P2 <P <P1 …… (1)

P1 is a pressing force on which the partition plates 113B and 114B of the limiting members 113 and 114 press the main tube 130, respectively. P is the internal pressure of the liquid that is partitioned by the limiting members 113 and 114 and stays in the central portion 130c of the main tube 130. P2 is an opening force P21 that opens the flow path 133z of the sub tube 133, or a resistance force P22 when a liquid flows through the flow path 133z.

Therefore, P1> P indicates that the limiting force by the limiting members 113 and 114 is a force that can maintain the liquid flow restriction in the main tube 130 even when pressed by the first pressing member 115. Further, P> P2 indicates a force that allows the pressing force of the first pressing member 115 to pass through the liquid via the sub tube 133.

In order to stably perform the drainage sampling operation, it is conceivable to make the pressing force P1 higher than the internal pressure P and to lower the opening force P21 and the resistance force P22. Here, the opening force P21 may be lowered without increasing the pressing force P1 more than necessary. In this case, it is possible to suppress the repeated application of a large pressing force P1 to the main tube 130, and to suppress the deterioration of the main tube 130.

When the flow path 133z is closed, that is, when P2> P, P2 is an opening force P21. The opening force P21 may be expressed by the equation (2). c: crack length, Gc: energy release rate, E: Young's modulus.

With reference to equation (2), it can be understood that the larger the crack length, the smaller the opening force P21. Therefore, if an opening 133b (see FIG. 10B) is provided at the connection position of the sub tube 133 with the main tube 130 as a crack, the liquid easily flows into the flow path 133z of the sub tube 133, that is, it is necessary for sampling. The pressing force by the first pressing member 115 can be small. The opening 133b may be an opening having a cross-sectional area larger than that of the flow path 133z even in a normal state (when the first pressing member 115 is not pressed). Further, the longer the length of the opening 133b in the direction along the flow path 133z, the easier it is for the liquid to flow into the flow path 133z of the sub tube 133, and the smaller the pressing force required by the first pressing member 115 for sampling. It's done.

Further, when the liquid is flowing in the flow path 113z, that is, when P2 <P, P2 is the resistance force P22. The resistance force P22 may be expressed by the equation (3). ε: strain, L: flow path length, λ: friction coefficient, ρ: density, v: flow velocity.

Next, the drainage sampling operation is verified using the tissue pulverized solution of the living body. Here, a case where a mouse is used as a living body is shown.

(Collecting tissue crushed liquid)
FIG. 9 is a diagram illustrating the preparation of a mouse tissue pulverized solution. The mouse tissue pulverized solution was prepared by the following procedure. The intestinal tissue sp1 is taken out from the mouse ms1 and immersed in the physiological saline ws1 contained in the container 310. Then, the container 310 in which the intestinal tissue sp1 is immersed in the physiological saline ws1 is set in the homogenizer 300. The homogenizer 300 crushes the intestinal tissue sp1 immersed in the physiological saline ws1 contained in the container 310, and disperses the crushed intestinal tissue sp1 in the physiological saline. As the homogenizer, various types such as an ultrasonic type that crushes the tissue by cavitation by ultrasonic waves, a stirring type that crushes the tissue by stirring, and a high pressure type that crushes the tissue by applying pressure can be used. By dispersing the tissue piece mz in the physiological saline ws1 by the homogenizer 300, a mouse tissue pulverized solution Lq1 is obtained. The drainage drainage Lq discharged from the living body may also be contaminated with various tissues, and it is assumed that the tissue crushed liquid Lq1 of the mouse is similar to the drainage drainage Lq.

(Shape of opening of sub tube)
Next, the opening 133b that may be provided near the branch point of the sub tube 133 will be considered.

FIG. 10A is an enlarged view showing the vicinity of the branch point of the main tube 130 when the sub tube 133 does not have the opening 133b. The tube central portion 130c of the main tube 130 may be filled with the tissue pulverizing solution Lq1 containing a large amount of tissue piece mz. When the pressing force is applied by the first pressing member 115, the internal pressure P of the tube central portion 130c rises, and when the opening force P21 represented by the equation (2) is exceeded, the flow path 133z of the sub tube 133 opens.

In FIG. 10A, since the opening 133b does not exist, the length c of the crack has a value of almost 0. When the opening 133b does not exist, the inlet of the flow path 133z is narrow (the cross-sectional area on the main tube 130 side is small), so that the opening force P21 when the tissue piece mz adheres to the vicinity of the inlet of the flow path 133z is likely to change. ..

FIG. 10B is an enlarged view showing the vicinity of the branch point of the main tube 130 when the sub tube 133 has the opening 133b. The shape of the opening 133b is, for example, a triangular cross section, but may be another shape (for example, a semicircular cross section or a polygonal shape other than a triangle). When the opening 133b is provided, the opening area (opening area of the opening 133b, cross-sectional area) at the connection position where the main tube 130 and the sub-tube 133 are connected is the cross-sectional area of the flow path 133z in the sub-tube 133 (flow path breakage). Area) may be larger. That is, the cross section of the opening 133b is wider than the cross section of the flow path 133z other than the opening 133b. For example, in FIG. 10B, in the flow path 133z, the cross-sectional area of the cross section s1 of the opening 133b may be larger than the cross-sectional area of the cross section s2 of the flow path 133z. Further, the length L11 of the opening 133b in the direction along the flow path 133z, which corresponds to the length c of the crack, may be, for example, 1 mm. In this case, the length c of the crack is sufficiently longer than the length of the tissue piece mz (about 100 μm), so that the opening force P21 for opening the flow path 133z is stable. Therefore, a stable drainage sampling operation can be performed. Not only the length c of the crack but also the width of the crack may be related to the opening force P21. The cross-sectional area and the like of the flow path 133z are based on the assumption that the flow path 133z is open. The flow path 133 is normally closed, and the cross-sectional area of the flow path 133z in this case is a value of 0.

Further, the opening area of the opening 133b may be determined by the size of the particles contained in the drain drainage Lq flowing through the main tube 130. For example, when the particles of the component to be controlled are small, they are less likely to be clogged near the inlet of the sub-tube 133, so that the vicinity of the inlet of the flow path 133z is less likely to be clogged and the quantitativeness of sampling does not deteriorate so much. The area may be relatively small or the opening 133b may not be provided. On the other hand, when the particles of the component to be controlled are large, the opening area of the opening 133b may be relatively large in consideration of the fact that the particles are easily clogged near the inlet of the flow path 133z.

As described above, by providing the drain drainage sensor 10 with the opening 133b, it is possible to prevent the tissue piece from being clogged in the vicinity of the branch point between the main tube 130 and the sub tube 133. Therefore, the drain drainage sensor 10 can collect the drainage drainage as the sampling liquid that has passed through the sub tube 133 in a stable amount. That is, the drain drainage sensor 10 can improve the quantitativeness of the sampling amount. The tissue piece may cause clogging in the vicinity of the branch point of the sub tube 133, but once it enters the flow path 133z, it can pass through the flow path 133z.

Further, since the drain drainage sensor 10 is provided with the opening 133b, it is difficult for the tissue piece mz to adhere to the vicinity of the inlet of the flow path 133z, and it is possible to reduce that the inlet of the flow path 133z is blocked. , The increase of the opening force P21 can be suppressed. Therefore, since the force of the internal pressure P of the tube central portion 130c can be reduced, the main tube 130 is less likely to be damaged, and drainage sampling can be performed stably.

FIG. 11A is a graph showing the measurement results of the weight per sampling in the case where the sub tube 133 has the opening 133b and the case where the sub tube 133 does not have the opening 133b. As shown in graph g22, when the subtube 133 does not have the opening 133b, the sampling amount of the tissue pulverized liquid varies greatly in the range of 0.1 g to 0.5 g. On the other hand, as shown in the graph g21, when the sub-tube 133 has the tapered opening 133b, the sampling amount of the tissue pulverized liquid is within a narrow range of 0.4 g to 0.5 g.

11B shows the average weight [g], standard deviation, C.I. V. It is a table showing [%]. When the subtube 133 does not have an opening 133b, the average weight is 0.32 [g], the standard deviation is 0.11, and C.I. V. It is 35.8 [%]. When the subtube 133 has an opening 133b, the average weight is 0.48 [g], the standard deviation is 0.02, C.I. V. It is 5.2 [%].

As a result, when sampling the tissue pulverized liquid, it is desirable that the opening 133b is provided and the outlet of the opening 133b is connected to the inlet of the flow path 133z. As a result, clogging of the tissue crushing liquid near the inlet of the flow path 133z is suppressed, and the tissue crushing liquid is easily introduced into the flow path 133z. The shape of the opening is not limited to the shape of the opening 133b, and it is desirable that the shape is such that the tissue piece mz can easily flow into the opening.

(Measurement of sampling liquid)
Next, a method of measuring the amount of the enzyme contained in the drain drainage (sampling liquid) sampled by the drainage sampling mechanism 110 will be described.

As described above, the blood cell separation / enzyme reaction mechanism 150 separates blood cells contained in the drainage fluid, reacts the enzyme with the reagent, and optically measures the amount of the enzyme.

(Structure of measuring tape)
FIG. 12A is a cross-sectional view showing the structure of the measuring tape 200. The measuring tape 200 has a four-layer sheet structure. The four-layered sheet consists of a PET (polyethylene terephthalate) sheet 201 arranged on the bottom layer, a reagent 202 laminated on the PET (polyethylene terephthalate) sheet 201, a spacer 203 laminated on the spacer 203, and a blood cell separation membrane arranged on the uppermost layer. It is composed of a glass film 204 as an example. The PET sheet 201 and the reagent 202 form an enzyme reaction sheet 205. The blood cell separation membrane can be separated from blood cells and non-blood cells (for example, amylase) based on the size of the controlled component (for example, blood cells, amylase, bilirubin) contained in the drainage fluid, the adsorption of the controlled component, and the like.

The glass film 204 is formed by bundling glass fibers into a sheet shape, and is formed like a non-woven fabric. The glass film 204 may be formed into a sheet by overlapping and folding a large number of glass fibers.

The glass film 204 adsorbs the component to be controlled. The adsorptive power of the glass film 204 may be different for each controlled component (for example, blood cells, amylase, bilirubin). Further, the adsorption force of the glass film 204 may change depending on the surface area of the glass film 204. The size of the surface area of the glass film 204 may be determined according to the density of the glass film 204. The glass film 204 may be charged and adsorbed. Specifically, the glass fiber may be positively charged, and blood cells (for example, phospholipids of blood cells) may be negatively charged in the sampling solution, and both may be electrically attracted to each other. On the other hand, the adsorption force between the glass fiber and the enzyme in the sampling solution may be weaker than the adsorption force between the glass fiber and the blood cell. In this case, the enzyme may move slightly on the glass fiber and then be adsorbed on the glass fiber.

The enzyme reaction sheet 205 contains a reagent 202 that reacts with the enzyme. Reagent 202 reacts with amylase, for example, when the enzyme is amylase, causing the amylase to turn yellow. In addition, the amylase that has reacted with this reagent absorbs a part of the measurement light. The reagent 202 may be, for example, an amylase activity measuring reagent used in a commercially available dry clinical chemistry test apparatus.

The spacer 203 has holes 203z (an example of an opening) for passing the sampling liquid sq2 containing an enzyme from the sampling liquid sq collected in the upper glass film 204 to the lower layer at regular intervals.

The PET sheet 201 is a translucent resin and transmits measurement light (for example, light having a wavelength of 410 nm as a peak value).

The amylase that has reacted with the reagent 202 easily absorbs light having a wavelength of 410 nm. On the other hand, the absorption wavelength of blood cells is 420 nm. Therefore, when the measurement light having a peak value of 410 nm is projected onto the amylase that has reacted with the reagent 202 and the absorbance of the amylase is measured from the scattered light based on the measurement light, it partially overlaps with the absorption wavelength of the blood cells of 420 nm, and accurate measurement is possible. It will be difficult. Therefore, the blood cell separation / enzyme reaction mechanism 150 separates blood cells and non-blood cells (for example, amylase and bilirubin) and measures the absorbance and the like.

12B and 12C are diagrams illustrating a state in which blood cell separation / enzymatic reaction is performed using the measuring tape 200. When the sampling liquid sq flowing out from the flow path 133z of the sub tube 133 is dropped on the glass film 204, blood cells are adsorbed on the glass film 204. Therefore, the sampling solution sq1 (a component of blood cells) containing a large amount of blood cells stays in the vicinity of the dropping position of the glass film 204.

On the other hand, when the sampling solution sq2 (enzyme component) containing a large amount of enzyme (for example, amylase) is dropped on the glass film 204, it is not immediately adsorbed at the dropping position of the glass film 204 and spreads from the dropping position. For example, it moves to the left in FIG. 12B. The sampling solution sq2 containing a large amount of amylase is dropped on the glass film 204, then moves and permeates the glass film 204 for about 1 second, and is adsorbed on the glass film 204. Therefore, the sampling liquid sq1 containing a large amount of blood cells stays in the vicinity of the dropping position of the glass film 204, and the sampling liquid sq2 containing a large amount of amylase stays in the position away from the dropping position of the glass film 204. That is, on the surface of the glass film 204, the blood cell adsorption region ar1 (an example of the first adsorption region) in which the sampling solution sq1 in which many blood cells are present resides and the non-sampling solution sq2 in which the sampling solution sq2 in which many non-blood cells such as enzymes are present are retained. It is separated into a blood cell adsorption region ar2 (an example of a second adsorption region).

Holes 203z are formed on the surface of the spacer 203 at regular intervals. The pore portion 203z is located so as to face the glass film 204 in which the sampling liquid sq2 containing a large amount of amylase is retained. The hole 203z is formed in such a size that the tip 116B of the second pressing member 116 can press the glass film 204 in order to send the sampling liquid sq2 that has moved in the plane of the glass film 204 to the enzyme reaction sheet 205.

In FIG. 12C, the tip portion 116B of the second pressing member 116 presses the glass film 204 in which the sampling liquid sq2 has penetrated. The sampling liquid sq2 that has permeated the glass film 204 flows out to the enzyme reaction sheet 205 via the pore 203z of the spacer 203. In the enzyme reaction sheet 205, the amylase contained in the sampling solution sq2 reacts with the reagent 202 and turns yellow (see the halftone dot display shown in the pore 203z and the reagent 202 in FIG. 12C).

The sensor unit 180 measures the absorbance of amylase contained in the sampling liquid sq2 that has permeated the measuring tape 200 sent out by the tape winding feeding mechanism 170. When measuring the absorbance of amylase, the LED 182 of the sensor unit 180 projects the measurement light having a peak value of 410 nm, which is the absorption wavelength, onto the measurement tape 200 permeated with the sampling solution sq2. The photo sensor 183 of the sensor unit 180 receives the scattered light that is projected from the LED 182 and is not absorbed by the amylase in the sampling liquid sq2. The CPU 181 of the sensor unit 180 measures the absorbance of amylase contained in the sampling solution sq2 based on the amount of scattered light received by the photo sensor 183.

(Examination of blood cell separation membrane)
In this embodiment, the glass membrane 204 is mainly used as the blood cell separation membrane, but this is compared with the case where other membrane materials are used. FIG. 13 is a table showing the characteristics of various materials used for the blood cell separation membrane. This table shows the comparison results when a monolith film, a cellulose film, and a glass film are used. In the study of this blood cell separation membrane, amylase was added to the stored blood of chickens as a measurement target.

In the monolith membrane, the pore size is as small as 1 μm, extraction exceeding 5 μl required for measurement cannot be performed, and the amount of amylase extracted is small. The cellulose membrane has a large pore size of 5-10 μm and cannot separate blood cells having a size of 10-15 μm. In addition, when a cellulose membrane is used, blood cells may be deformed and subdivided blood cells may pass through the cellulose membrane and the necessary separation may not be possible. On the other hand, in the glass film 204, blood cells can be separated by utilizing the difference in the adsorptive power of the components to be controlled, and an amount exceeding 5 μl required for measurement can be secured.

FIG. 14 is a diagram illustrating a method of separating blood cells and non-blood cells contained in the sampling solution sq along the surface of the blood cell separation membrane. Blood cells ba have a higher affinity for glass membrane 204 than non-blood cells and are easily adsorbed on glass membrane 204. Therefore, the blood cell ba stays in the vicinity of the dropping position on the glass film 204. Amylase rz as an example of non-blood cells contained in the sampling solution sq has a lower affinity with the glass membrane 204 than the blood cells ba, and is less likely to be adsorbed by the glass membrane 204 as compared with blood cells. Therefore, amylase rz moves and permeates along the glass film 204 due to, for example, capillarity. Amylase rz is adsorbed and stays in a region distant from the region where blood cells ba stay. Separation of blood cells using a blood cell separation membrane in this way is also referred to as membrane separation.

FIG. 15 is a graph showing the correlation between the change in absorbance due to membrane separation and the change in absorbance due to centrifugation. As a measurement target, amylase was added to the stored blood of chickens, and the change in absorbance for 1 minute in the measurement of amylase activity was examined. Amylase activity represents the ability of amylase to react with reagent 202 and is expressed in units U / L. The vertical axis of the graph shows the amount of change in absorbance ΔA due to membrane separation. The horizontal axis of the graph shows the amount of change in absorbance ΔA due to centrifugation. Assuming that the amount of change in absorbance ΔA due to membrane separation is y and the amount of change in absorbance ΔA due to centrifugation is x, this graph g31 is represented by the formula (4). The correlation coefficient is 0.999.
y = 1.03x …… (4)

Therefore, it can be said that the change in absorbance due to membrane separation can be obtained with the same accuracy as the change in absorbance due to centrifugation. In other words, it can be said that blood cell separation by membrane separation is possible with the same accuracy as blood cell separation by centrifugation. Therefore, even if a large device such as a centrifuge is not used, the same measurement results such as absorbance can be obtained by using a blood cell separation membrane such as a glass membrane 204.

(Measurement of amylase activity)
16A, 16B, and 16C are diagrams illustrating various methods for measuring amylase activity. To measure amylase activity, a liquid containing amylase is added to the enzyme reaction sheet 205. As this addition method, a standard method, an osmotic filtration method, and a transfer method were investigated.

FIG. 16A shows the standard method. In the standard method, the liquid sqx1 containing amylase separated by centrifugation is dropped onto the enzyme reaction sheet 205 with a micropipette MP.

FIG. 16B shows an osmotic filtration method. In the osmotic filtration method, the enzyme reaction sheet 205 is brought into contact with the back surface of the glass film 204 in advance, and the sampling solution sqx2 is dropped on the surface of the glass film 204. In this case, the blood cell component contained in the sampling solution sqx2 stays in the vicinity of the dropping position of the glass film 204. On the other hand, the amylase component contained in the sampling solution sqx2 permeates through the glass film 204 and moves, and permeates up to the enzyme reaction sheet 205. The sampling solution sqx2 may be, for example, prepared by adding amylase to the stored blood of chicken.

FIG. 16C shows the transcription method. In the transfer method, the enzyme reaction sheet 205 is not brought into contact with the glass film 204 in advance, and the sampling solution sqx2 is dropped on the surface of the glass film 204. In this case, the blood cell component contained in the sampling solution sqx2 stays in the blood cell adsorption region ar1 near the dropping position of the glass film 204. On the other hand, the amylase component contained in the sampling solution sqx2 permeates the glass membrane 204, moves, and stays in the non-blood cell adsorption region ar2. After the transfer of the amylase component, the enzyme reaction sheet 205 is brought into contact with the glass film 204, and the amylase is transferred from the glass film 204 to the enzyme reaction sheet 205.

17A, 17A, and 17C are graphs showing the measurement results of amylase activity in the various measurement methods shown in FIGS. 16A, 16B, and 16C. The vertical axis of each graph shows the amount of change in absorbance (ΔA) in various measurement methods. The horizontal axis shows amylase activity.

In the standard method, as shown in FIG. 17A, it was confirmed that the correlation between the amount of change in absorbance (ΔA) and the amylase activity was high (the relationship was close to linear). In the osmotic filtration method, as shown in FIG. 17B, it was confirmed that the correlation between the amount of change in absorbance (ΔA) and the amylase activity was low. In the transcription method, as shown in FIG. 17C, it was confirmed that the correlation between the amount of change in absorbance (ΔA) and the amylase activity was high (the relationship was close to linear), as in the standard method. Further, in the transcription method, the correlation coefficient was 0.988 in the range of amylase activity: 75-2400 U / L, and C.I. V. Is 5.72%.

The standard method requires a centrifuge to perform the centrifuge. Therefore, if the drain drainage sensor 10 includes a centrifuge, the drainage drainage sensor 10 becomes expensive and large in size, and portability is lowered.

In the osmotic filtration method, the glass film 204 and the enzyme reaction sheet 205 come into contact with each other in advance, so that the reagent 202 in the enzyme reaction sheet 205 tends to flow out. In this case, the reaction between the reagent 202 and amylase may be insufficient. The low correlation between the amount of change in absorbance (ΔA) and amylase activity in FIG. 17B is considered to be due to insufficient reaction between the reagent 202 and amylase.

In the transfer method, the contact time between the glass film 204 and the enzyme reaction sheet 205 is shorter than in the case of the osmotic filtration method, so that the reagent 202 in the enzyme reaction sheet 205 is unlikely to flow out. Therefore, in FIG. 17C, it is considered that the correlation between the amount of change in absorbance (ΔA) and the amylase activity is high. Further, since the graphs of FIGS. 17A and 17C have similar shapes, the transfer method can obtain the measurement results with the same measurement accuracy as the standard method. In addition, in FIG. 12C, the region containing amylase in the glass film 204 may come into contact with the enzyme reaction sheet 205 after the amylase is transferred (after separation). That is, in FIG. 12C, the transfer method is adopted.

FIG. 18 is a flowchart showing a procedure for measuring amylase activity by the drainage drainage management system 5. This measurement is set at an appropriate time, for example, once an hour, similar to the drainage sampling operation.

The CPU 181 of the sensor unit 180 outputs a command signal via the motor drive unit 187 and drives the motor 175 so as to send the measurement tape 200 in the winding direction (S11). When the motor 175 rotates, the take-up reel 172 rotates, and in order to perform the drainage sampling operation, the measurement tape 200 is wound and fed so that the drop point is directly below the sub tube 133 (opposite position). The reel 151 sends out the measuring tape 200.

The CPU 181 performs a drainage sampling operation, and drops the sampling liquid sq onto the measuring tape 200 (S12). This drainage sampling operation may be performed by the procedure shown in the flowchart of FIG.

The CPU 181 waits for a predetermined time to separate blood cells and move the sampling solution sq (S13). Of the sampling liquid sq dropped on the glass film 204 of the measuring tape 200 during the standby time, the sampling liquid sq1 containing a large amount of blood cells stays in the vicinity of the dropping position (blood cell adsorption region ar1) and contains amylase. The sampling solution sq2 moves to a location (non-blood cell adsorption region ar2) away from the dropping position (see FIG. 12B).

The CPU 181 outputs a command signal to the motor drive unit 187, and drives the motor 175 so as to move the measurement tape 200 by a predetermined amount in the winding direction (S14). When the motor 175 rotates, the take-up reel 172 rotates, the measuring tape 200 is moved from the dropping position by a predetermined amount in the take-up direction (to the right in FIG. 12C), and is taken up by the take-up reel 172 and fed. It is sent out to reel 171. This predetermined amount corresponds to the distance from the dropping position of the sampling liquid sq to the position where the sampling liquid sq2 has penetrated, that is, the distance between the outlet of the sub tube 133 and the hole 203z of the spacer 203.

The CPU 181 presses the second pressing member 116 by the pressurizing unit drive unit 186 in a state where the glass film 204 in which the sampling liquid sq2 has penetrated is located on the hole portion 203z (opposite position) of the spacer 203 (S15). .. In this pressing, the tip portion 116B of the second pressing member 116 presses the glass film 204 in which the sampling liquid sq2 has penetrated, for example, from directly above. The sampling liquid sq2 that has permeated the glass film 204 passes through the pore portion 203z and seeps into the enzyme reaction sheet 205.

The sampling liquid sq2 does not seep out from the glass film 204, and the 204 is elastically deformed through the hole 203z, so that the permeation portion (adsorption portion) of the sampling liquid sq2 of the glass film 204 and the enzyme reaction sheet 205 come into contact with each other. You may be made to do so. In this case, the glass film 204 may be configured to be elastically deformable.

The CPU 181 waits for the reaction time between the amylase and the reagent (S16). During this reaction time, the reagent 202 contained in the enzyme reaction sheet 205 and the amylase contained in the sampling solution sq2 react with each other, and the reacted amylase turns yellow.

The CPU 181 performs optical reading on the reaction site between the amylase and the reagent 202 (S17). In this optical reading, the CPU 181 turns on the LED 182 and projects the measurement light toward the reaction site. At the reaction site, a part of the projected measurement light is absorbed by amylase and the other part is scattered. The CPU 181 receives the light scattered by the photo sensor 183, and calculates the amount of change in absorbance (ΔA) based on the amount of the received light.

The CPU 181 calculates the amylase activity from the amount of change in absorbance (ΔA), for example, based on the graph shown in FIG. 17C (S18). The CPU 181 communicates with the drain drainage monitor 20 by the wireless chip 184, and obtains measurement data related to amylase (for example, change in amylase absorbance (ΔA), amylase activity value, amylase concentration value) as information at the measurement time. (S19). When the CPU 26 of the drain drainage monitor 20 receives measurement data and measurement time information regarding amylase from the drain drainage sensor 10 via the wireless chip 28, various data (measurement data, measurement time, and others) are received via the display 21. Data) is displayed.

According to the measurement procedure of such a controlled component (for example, amylase), in the drainage drainage management system 5, the CPU 181 controls each part of the blood cell separation / enzyme reaction mechanism 150.
The state of the sampling liquid sq in which the drainage liquid is sampled can be automatically measured and the measurement data can be derived. Further, the drain drainage management system 5 can display information on the drain drainage monitor 20 and can visualize information on the components to be managed such as measurement data. Therefore, the user can easily grasp the recovery tendency of the patient.

FIG. 19 is a diagram showing a display of the drain drainage monitor 20. As an example, a graph 22 showing the measurement result of the amount of change in absorbance (ΔA) indicating the amylase activity may be displayed on the display 21 arranged in front of the drain drainage monitor 20. In addition, the display 21 includes various explanatory texts 23 such as the patient's name, a meter 24 indicating the amount of change in absorbance (ΔA), and a status marker 25 for notifying the patient's condition (normal / abnormal). May be displayed.

In the graph 22, the broken line L1 indicates the upper limit of the normal range, and the broken line L2 indicates the lower limit of the normal range. If the postoperative condition of the patient is normal, the amount of change in absorbance due to amylase in the drainage fluid flowing in the drain tube 30 connected to the patient's body gradually decreases with the passage of time after the operation. In this example, the transition of each measurement result over time is maintained within the normal range. At this time, the character "normal" is displayed as the status marker 25. On the other hand, when the transition of each measurement result over time is out of the normal range, the character "abnormal" may be displayed as the state marker 25.

(Measurement of bilirubin)
In the above, amylase, which is a digestive enzyme, has been mainly described as a controlled component in drainage Lq. As an example of organ secretion, bilirubin contained in bile, urine, and the like can also be one of the controlled components. Since bilirubin itself has a yellow pigment, it is possible to optically detect the concentration of bilirubin in a non-contact manner. Therefore, when measuring the concentration of bilirubin, an enzyme reaction sheet for reacting with the reagent and coloring is unnecessary.

FIG. 20 is a cross-sectional view showing the structure of the measuring tape 200A. The measuring tape 200A has a two-layer structure of a glass film 204A and a PET sheet 201A.

21A and 21B are diagrams illustrating a method for measuring bilirubin. In FIG. 21A, bilirubin is measured using a spectrophotometer BK (standard method). In FIG. 21B, bilirubin is measured using a blood cell separation membrane (membrane measurement).

Similar to amylase, bilirubin is also membrane-separable as described in FIG. That is, bilirubin as an example of non-blood cells contained in the sampling solution sq has a lower affinity with the glass membrane 204 than the blood cells, and is less likely to be adsorbed by the glass membrane 204 as compared with the blood cells. Therefore, bilirubin moves along the glass film 204 and permeates, for example, by capillarity. Bilirubin is adsorbed and stays in a region distant from the region where blood cells ba stay.

As shown in FIG. 21B, in the membrane measurement, the region of the sampling solution containing a large amount of bilirubin (non-blood cell adsorption region ar3) is obtained by adsorbing the sampling solution sq to the glass film 204 by utilizing the difference in the adsorption force between blood cells and bilirubin. ) Is formed. Specifically, when the sampling solution sq is dropped on the glass film 204, blood cells are preferentially adsorbed on the glass film 204. That is, the adsorbing force of blood cells on the glass film 204 is larger than the adsorbing force of bilirubin on the glass film 204. In the glass membrane 204, blood cells are adsorbed in the blood cell adsorption region ar1 and bilirubin is adsorbed in the non-blood cell adsorption region ar3. The absorbance of bilirubin can be measured by measuring the non-hemadsorption region ar3 on which bilirubin is adsorbed by using light having a wavelength of 410 nm as a peak value as the measurement light.

FIG. 22A is a graph showing the measurement results of bilirubin when the standard method is used. The vertical axis of the graph represents the absorbance (Abs). The horizontal axis represents the amount of bilirubin (mg / ml). In the measurement of bilirubin by the spectrophotometer BK, the absorbance (Abs) and the amount of bilirubin (mg / ml) have a high correlation in the range where the amount of bilirubin is 0-32 (mg / ml).

FIG. 22B is a graph showing the measurement result of bilirubin when the membrane measurement is used. The vertical axis of the graph represents the absorbance (Abs). The horizontal axis represents the amount of bilirubin (mg / ml). Even in the measurement of bilirubin using the glass film 204, the absorbance (Abs) and the amount of bilirubin (mg / ml) have a high correlation (the relationship is close to linear). Here, the correlation coefficient is 0.987 in the range of bilirubin amount: 0-32 (mg / ml), and C.I. V. Is 1.06%.

Therefore, it can be said that the absorbance by the membrane measurement can be obtained with the same accuracy as the measurement accuracy of the absorbance by the spectrophotometer BK. By measuring bilirubin using a blood cell separation membrane such as a glass membrane 204, the drain drainage sensor 10 does not require a large-sized device such as a spectrophotometer BK, is excellent in portability, and can reduce costs. ..

The measurement data such as the absorbance of bilirubin may be sent to the drain drainage monitor 20 and displayed on the display 21.

(Variation example of measuring tape)
In FIG. 12A, as the measuring tape 200, a tape having a four-layer structure used for measuring amylase is illustrated. Further, FIG. 20 illustrates a tape having a two-layer structure used for measuring bilirubin. The structure of the measuring tape is not limited to the structure of these tapes.

FIG. 23 is a diagram showing the structure of a measuring tape 200B capable of measuring the states of both amylase and bilirubin. The measuring tape 200B is manufactured so as to repeat the above-mentioned four-layer structure and two-layer structure in the length direction of the measuring tape 200B. When measuring the state of amylase, the drain drainage sensor 10 uses the region AS1 having a four-layer structure in the measuring tape 200B. On the other hand, when measuring bilirubin, the drain drainage sensor 10 uses the region AS2 having a two-layer structure in the measuring tape 200B.

As described above, by using the measuring tape 200B having the region AS2 having a two-layer structure and the region ASS1 having a four-layer structure, the drain drainage sensor 10 can simultaneously measure the types of substances that the drain drainage sensor 10 can measure. Can be increased. Further, since the drain drainage sensor 10 can be shared in the measurement of a plurality of different managed components, the cost is reduced and the space can be saved as compared with the case where two drain drainage sensors are provided. Further, in the measurement of a plurality of different controlled components, only one measuring tape 200 is required, so that the cost is reduced and the space can be saved as compared with the case where two measuring tapes 200 are used.

Although the embodiments have been described above with reference to the drawings, it goes without saying that the present invention is not limited to these examples. It is clear that a person skilled in the art can come up with various modifications or modifications within the scope of the claims, which naturally belong to the technical scope of the present invention. Understood.

In the above embodiment, it is exemplified that the drain drainage sensor 10 includes two limiting members 113 and 114. The number of limiting members 113 and 114 is not limited to two. The number of limiting members may be one or three or more as long as a certain amount of drainage drainage Lq is blocked and can stay in the central portion 130c of the pipe. Further, a member (for example, a valve) other than the limiting member may be provided as long as a certain amount of drainage drainage is blocked and can stay in the central portion 130c of the pipe. For example, the valve may be electrically opened and closed to switch between passage and retention of drainage drainage.

In the above embodiment, it is exemplified that the drain drainage sensor 10 is provided with the two limiting members 113, 114 and the first pressing member 115 as separate bodies, but the limiting members 113, 114 and the first pressing member 115 At least a part of it may be provided as a unit. For example, one third pressing member 140 may be provided instead of the two limiting members 113, 114 and the first pressing member 115.

FIG. 24 is a perspective view showing a structural example of the third pressing member 140. The third pressing member 140 includes two first pressing portions 141, a second pressing portion 142, and a rotation shaft 143.

The first pressing portion 141 is located at both ends of the third pressing member 140 along the direction in which the drain drainage Lq flows in the main tube 130. In the first pressing portion 141, the rotation shaft 143 passes along the direction in which the main tube 130 extends. The first pressing portion 141 rotates about the rotation shaft 143 as the center of rotation. The first pressing portion 141 has a substantially fan-shaped cross section in a direction perpendicular to the direction in which the drain drainage Lq flows, and has, for example, a substantially semicircular shape in which the central angle of the fan shape is approximately 180 degrees. The distance between the center of rotation of the first pressing portion 141 and the outer circumference of the first pressing portion 141 is not constant. Therefore, the first pressing portion 141 restricts the flow of the drain drainage Lq flowing through the main tube 130 or releases the restriction on the flow of the drainage drainage Lq by the rotation of the rotation shaft 143. Therefore, the first pressing portion 141 acts in the same manner as the limiting members 113 and 114.

The second pressing portion 142 is located between the two first pressing portions 141 in the third pressing member 140. The rotation shaft 143 passes through the second pressing portion 142 along the direction in which the main tube 130 extends. The second pressing portion 142 rotates about the rotation shaft 143 as the center of rotation. The second pressing portion 142 has a substantially fan-shaped cross section in a direction perpendicular to the direction in which the drain drainage Lq flows, and has, for example, a fan-shaped central angle of approximately 60 degrees. The distance between the center of rotation of the second pressing portion 142 and the outer circumference of the second pressing portion 142 is not constant. Therefore, the second pressing portion 142 presses the drain drainage Lq whose distribution is restricted by the first pressing portion 141 in the main tube 130 by the rotation of the rotating shaft 143 to pass through the sub tube 133, or the drain drainage liquid. It may not pass through the sub tube 133 without pressing Lq. Therefore, the second pressing portion 142 operates in the same manner as the first pressing member 115.

The rotation shaft 143 may rotate according to a drive signal from the CPU 181 of the sensor unit 180. The rotation of the rotation shaft 143 causes the first pressing portion 141 and the second pressing portion 142 to rotate.

The first pressing portion 141 and the second pressing portion 142 have a substantially fan-shaped cross section, but the central angle (for example, 180 degrees) of the fan shape in the cross section of the first pressing portion 141 is the cross section of the second pressing portion 142. It is made larger than the central angle of the sector (for example, 60 degrees) in. That is, when the cross-section fan shape of the first pressing portion 141 and the cross-section fan shape of the second pressing portion 142 are projected onto the projection plane parallel to these cross sections, the cross-section fan shape of the second pressing portion 142 having a small central angle has a central angle. It is included inside the cross-sectional fan shape of the first pressing portion 141 having a large size (see, for example, FIGS. 25A to 25C).

25A, 25B, and 25C are cross-sectional views taken along the line AA showing an example of the states of the third pressing member 140 and the main tube 130 in each rotational state of the third pressing member 140. FIG. 25A corresponds to the state of FIG. 24 and shows a no-load state (state α). In the state α, neither the first pressing portion 141 nor the second pressing portion 142 presses the main tube 130. Therefore, the state α corresponds to the state A in FIG.

FIG. 25B shows a state β rotated by a predetermined angle from the state α. In the state β, the main tube 130 is pressed at two points by the two first pressing portions 141, but is not pressed by the second pressing portion 142. That is, the main tube 130 is pressed by the two first pressing portions 141, and the drain drainage Lq flowing through the main tube 130 stays between the two first pressing portions 141. On the other hand, the accumulated drain drainage Lq is not yet pressed by the second pressing portion 142, so that it does not flow into the sub tube 133. Therefore, the state β corresponds to the state B in FIG.

FIG. 25C shows a state γ rotated by a predetermined angle from the state α. In the state γ, the main tube 130 is pressed by the first pressing portion 141 and is pressed by the second pressing portion 142. That is, the drain drainage Lq flowing through the main tube 130 is pressed by the two first pressing portions 141 and stays between the two first pressing portions 141 (at the tube central portion 130c). Further, the drain drainage Lq staying in the central portion 130c of the pipe is pressed by the second pressing portion 142, flows into the sub tube 133, passes through, and is extracted as the sampling liquid Sq. Therefore, the state γ corresponds to the state C in FIG.

In this way, the drain drainage sensor 10 uses a mechanism such as a camshaft by rotating the third pressing member 140, so that a certain amount of sampling liquid is sampled from the drain drainage Lq flowing through the main tube 130. Sq can be extracted. Therefore, it is possible to limit the flow of the liquid in the main tube 130 and extract the liquid from the sub tube 133 by using one member, and it is possible to simplify the configuration related to liquid sampling. Further, since the third pressing member 140 only needs to drive the rotating shaft 143, the number of driving points can be reduced as compared with the case of driving the limiting members 113, 114 and the first pressing member 115, for example. The possibility of mechanical failure can be reduced. Therefore, the drain drainage sensor 10 can improve the long-term reliability of liquid sampling by using the third pressing member 140.

In the above embodiment, it is exemplified that the drainage liquid discharged from the living body via the drain tube 30 is the target of sampling and measurement, but the liquid other than the drainage liquid may be the target of sampling and measurement. For example, a biological fluid discharged from or introduced into a living body through a body fluid guide tube may be a target for sampling or measurement.

The fluid guide tube may include, for example, a drain (drain tube), a catheter (catheter tube), a dosing tube (tube used for dosing). Biofluid flows through the body fluid guide tube.

The drain may include drains for cranial nerves, otolaryngology, respiratory organs, circulatory organs, mammary gland / endocrine system, upper gastrointestinal tract, biliary hepatopancreatic system, urinary system, gynecology, orthopedic surgery, and the like. The drain for the cerebral nerve may include a ventricular drain, a cistern drain, an epidural drain, a subcutaneous drain, a hematoma cavity drain, a lumbar drain, a drain used after endoscopic surgery, and the like. Otorhinolaryngological drains may include drains used after head and neck surgery, and the like. Respiratory drains may include chest tubes, mediastinal drains, and the like. Cardiovascular drains may include pericardial drains, drains used after head and neck surgery, and the like. The drain for breast and endocrine may include a drain used after breast cancer surgery, a mastitis drain, a drain used after thyroid surgery, and the like. The drain for the upper gastrointestinal tract may include a thoracic / mediastinal drain, a cervical drain, an abdominal drain, an upper abdominal peritonitis drain, an intra-abdominal abscess drain, a drain used after gastric surgery, and the like. Biliary-hepatic pancreatic drains are used after percutaneous transhepatic bile sac drain, percutaneous transhepatic bile drain, hepatic abscess drain, endoscopic biliary drain, drain for acute pancreatitis, retroperitoneal abscess drain of the lower gastrointestinal tract, and after rectal cancer surgery. The drain, perianal abscess drain, etc. may be included. The drain for the urinary system may include a drain used after general surgery, a drain used after endoscopic surgery, a drain used for a percutaneous and transurethral approach, and the like. The gynecological drain may include a drain used after laparotomy, a drain used after endoscopic surgery, and the like. Orthopedic drains may include joint cavity drains, etc. In addition, other drains may include an incision and drainage drain, and the like.

The catheter may include an angiography catheter, a balloon catheter, a heart catheter, a cerebrovascular catheter, a catheter used for cancer catheter treatment, an indwelling vascular catheter, a urinary tract catheter, and the like.

The dosing tube may include a tube used for a dosing device (dosing system), and the like. The dosing device may include a dosing pump (TCI (Target Controlled Infusion) pump) that directly controls the concentration of the drug in the blood, and the like. The TCI pump controls the operation of the pump to regulate the administration rate of the drug and control the blood concentration of the drug to reach the target blood concentration.

FIG. 26 is a diagram illustrating that a biofluid containing a drug or an infusion solution (hereinafter, also referred to as a drug or the like) is introduced into the patient PA1 by the TCI pump 10A. A biological fluid containing a drug or the like is introduced from the TCI pump 10A into the patient PA1 via the dosing tube 30A. Further, the biological fluid is sent from the patient PA1 to the TCI pump 10A via the dosing tube 30A. That is, the TCI pump 10A adjusts the dose and administration rate of the drug to the patient PA1, circulates the biological fluid with the patient PA1, and controls the concentration of the drug in the body of the patient PA1. With such a TCI pump 10A, for example, it is possible to realize a dosing system that directly controls the drug concentration in the blood of patient PA1.

The TCI pump 10A may have the same configuration as the drain drainage sensor 10 except for the configuration related to the control of the administration of the drug administered to the patient PA1, for example, the same configuration as shown in FIG. good. The TCI pump 10A may sample the biological fluid from the TCI pump 10A toward the patient PA1 and measure the controlled component. Further, the TCI pump 10A may sample the biological fluid from the patient PA1 to the TCI pump 10A and measure the controlled component.

In the above embodiment, the use of the glass membrane 204 as the blood cell separation membrane is exemplified, but other members may be used. For example, a positively charged membrane capable of adsorbing blood cells may be used, or a member having an adsorption mechanism other than charge adsorption may be used.

In the above embodiment, it is illustrated that the data of each controlled component in the sampling liquid sq is acquired in chronological order. In addition to these time-series data, time-series data of the total drainage amount of the drain drainage Lq and the sampling liquid sq may be acquired. The time-series data of the total drainage amount of the drain drainage Lq may be acquired, for example, based on the output value of a sensor (for example, a strain sensor) that measures the weight of the drain bag. The time-series data of the total discharge amount of the sampling liquid sq may be acquired, for example, by measuring the extraction amount of the sampling liquid sq each time by the drainage sampling mechanism 110 and accumulating the respective doses. Further, the time-series data may include data on the amount of drainage liquid Lq and sampling liquid sq discharged per unit time.

In the above embodiment, the CPU 181 of the drain drainage sensor 10 may calculate the concentration of amylase based on the amount of change in the absorbance of amylase. The amylase concentration data is an example of measurement data. For example, the correspondence information between the amount of change in the absorbance of amylase and the concentration of amylase may be stored in a memory or the like, and the concentration of amylase may be derived based on this correspondence information. The CPU 181 of the drain drainage sensor 10 may calculate the concentration of bilirubin based on the absorbance of bilirubin. The bilirubin concentration data is an example of measurement data. For example, the correspondence information between the absorbance of bilirubin and the concentration of bilirubin may be stored in a memory or the like, and the concentration of bilirubin may be derived based on this correspondence information.

In the above embodiment, the drain drainage sensor 10 and the drain drainage monitor 20 are configured as separate devices, but the drain drainage sensor 10 and the drain drainage monitor 20 are configured as devices having the same housing. May be good.

In the above embodiment, the drain tube 30 is connected to the main tube 130, but the main tube 130 may be a part of the drain tube 30.

In the above embodiment, the blood cell separation / enzyme reaction mechanism 150 of the drainage drainage sensor 10 may measure the blood concentration contained in the sampling solution sq as a controlled component. The blood concentration in the sampling solution sq can be measured, for example, as follows. For example, the blood concentration in the sampling solution sq can be derived by irradiating the blood cell adsorption region ar1 (sampling solution sq1 containing a large amount of blood cells) with the measurement light and receiving the scattered light. As the measurement light for measuring the blood concentration, for example, light having a wavelength of 660 nm or 850 nm as a peak value may be used. As described above, the biological fluid (for example, a controlled component) may contain blood cells of a living body (for example, venous blood of a patient). The drainage drainage sensor 10 can evaluate the patient's condition based on the blood condition by measuring the patient's venous blood.

In the above embodiment, an example relating to liquid sampling has been disclosed, but the embodiment is not limited thereto. For example, it is clear that it can be applied to applications such as dispensing and dropping liquids, in which liquids are discharged in constant volumes.

In this way, the drainage drainage management system 5 collects, separates, dispenses, analyzes, etc. the drainage drainage Lq discharged from the patient's living body, and uses an index for examining the subsequent treatment for the patient. , Can be provided to the user. Further, collection, separation, dispensing, analysis, etc. of the drainage drainage Lq can be performed by the drainage drainage sensor 10 which is one device.

Further, it is assumed that the patient wears the drain tube 30 on the patient's body for, for example, about one week. The frequency of sampling the drain drainage Lq may be, for example, about once an hour or about 170 times a week.

As described above, the drain drainage management system 5 includes a drainage sampling mechanism 110 (an example of an acquisition unit) that acquires at least a part of the drainage drainage discharged from the living body through the drain tube 30, and the acquired drainage drainage. A blood cell separation / enzyme reaction mechanism 150 (an example of a generator) that measures controlled components (for example, blood, amylases, and virylbin) in a liquid and generates measurement data (an example of first information on the controlled components). A memory 27 (an example of a recording unit) in which data associated with the measurement data and the time when the measurement data is detected is recorded, and time-series data representing changes over time of the measurement data based on this data (an example of a recording unit). A display 21 (an example of a display unit) for displaying (an example of the second information) may be provided. The obtained drain drainage may be, for example, a sampling liquid sq. Acquiring at least a part of the drainage drainage discharged from the living body through the drainage tube 30 may include "preparation" in which the drainage drainage is obtained from the middle of the drainage tube 30. The drain tube 30 is an example of a body fluid guide tube. Drain drainage is an example of biofluid. The acquisition unit may acquire at least a part of the biological fluid introduced into the living body through the body fluid guide tube.

As a result, the drain drainage management system 5 can extract the controlled component that affects the drain drainage from the drain tube to the outside. Further, the drain drainage management system 5 can measure the extracted controlled component and derive measurement data based on the measurement result. Further, the drain drainage management system 5 displays the time-series data showing the change over time of the measurement data on the display 21, so that the user (doctor / nurse, other medical personnel) can check the drainage drainage state. When evaluating, instead of visual evaluation (or in addition to visual evaluation), evaluation can be performed based on time-series data. Therefore, the user can more objectively evaluate the patient's recovery tendency as compared with the evaluation based only on visual inspection.

Further, as with the drainage fluid, the controlled component that affects the biological fluid can be extracted from the drain tube to the outside of the biological fluid other than the drainage fluid. In addition, the extracted controlled component can be measured, and measurement data based on the measurement result can be derived. Further, by displaying the time-series data showing the change over time of the measurement data on the display 21, when the user evaluates the state of the biological fluid, instead of the visual evaluation (or the visual evaluation). In addition), it can be evaluated based on time series data. Therefore, the user can more objectively evaluate the patient's recovery tendency based on the biological fluid, as compared with the evaluation based only on visual inspection.

In this way, the drain drainage management system 5 can objectively evaluate the state of the controlled component contained in the biological fluid discharged from the living body or introduced into the living body.

The controlled component may include an enzyme, bilirubin, or blood cell component.

As a result, the drainage drainage management system 5 can manage, for example, the components of the enzyme, bilirubin, or blood cells that the patient drains or introduces into the patient, and it becomes easy to grasp the patient's condition.

The first information may include information on the amount of enzyme, the amount of bilirubin, or the amount of blood cells.

Thereby, the drain drainage management system 5 can measure, for example, the amount of the enzyme discharged or introduced into the patient, the amount of bilirubin, or the amount of blood cells, and it becomes easy to grasp the state of the patient.

Controlled components may include blood cells and non-blood cells. The blood cell separation / enzyme reaction mechanism 150 is a state of a glass membrane 204 (an example of a blood cell separation membrane) that separates blood cells and non-blood cells (for example, amylase and bilirubin) from drainage, and a non-blood cell separated by the glass membrane 204. A sensor unit 180 (an example of a measuring unit) for measuring the blood cells may be provided.

As a result, the drain drainage management system 5 can suppress the measurement of a mixture of blood cell components having characteristics different from those of the non-blood cell when measuring the state of the non-blood cell by using the glass film 204. Therefore, the drain drainage management system 5 can improve the measurement accuracy of the non-blood cell component. Therefore, the drainage drainage management system 5 can objectively evaluate the state of non-blood cells contained in the drainage drainage while improving the measurement accuracy of the non-blood cell component. Further, since the drain drainage management system 5 can separate blood cells and non-blood cells by membrane separation, it is not necessary to use a centrifuge, and the device for separating blood cells and non-blood cells is downsized and cost-reduced. Is possible.

Further, the glass film 204 may have a larger adsorption force with blood cells than the adsorption force with non-blood cells. The sensor unit 180 may measure the absorbance of non-blood cells separated from and adsorbed on the glass film 204.

Thereby, the drain drainage management system 5 can easily separate blood cells and non-blood cells by utilizing the difference in the suction force with the glass film 204. Further, the drain drainage management system 5 can derive (for example, calculate) the concentration of non-blood cells, for example, by measuring the absorbance of non-blood cells, based on the absorbance, for example, the correspondence with the absorbance is uniquely determined.

Further, the glass film 204 moves non-blood cells along the glass film 204 and adsorbs blood cells in the blood cell adsorption region ar1 (an example of the first adsorption region) and the non-blood cell adsorption regions ar2 and ar3 (an example of the first adsorption region). An example of the second adsorption region) and may be formed.

Thereby, the drain drainage management system 5 can separate the positions of the region where the blood cell component stays and the region where the non-blood cell component stays in the glass film 204. Therefore, the drain drainage management system 5 can distinguish and detect each state of blood cells and non-blood cells, for example, by irradiating each region with measurement light.

Further, the drain drainage management system 5 may include an enzyme reaction sheet 205. Non-blood cells may contain enzymes. The enzyme reaction sheet 205 may react with the enzyme separated by the glass film 204. The sensor unit 180 may measure the absorbance of the reacted enzyme with the enzyme reaction sheet 205.

As a result, the drainage drainage management system 5 can color the enzyme using the enzyme reaction sheet 205 even when the colorless enzyme is a controlled component. Therefore, when the colored enzyme is irradiated with the measurement light, the enzyme in the enzyme reaction sheet 205 can scatter the measurement light, and the photosensor 183 can receive the scattered light. Therefore, the drainage drainage management system 5 can measure the absorbance of the enzyme even when the colorless enzyme is a controlled component, and can derive the concentration of the enzyme based on the absorbance.

Further, the enzyme reaction sheet 205 may be configured to come into contact with the non-blood cell adsorption region ar2 in the glass film 204 after at least a part of the drainage drainage has been acquired by the drainage sampling mechanism 110.

As a result, the non-blood cells move in the glass membrane 204 and reach the non-blood cell adsorption region ar2, so that the enzyme and the enzyme reaction sheet 205 can come into contact with each other. Further, the drain drainage management system 5 reduces the contact time between the glass film 204 and the enzyme reaction sheet 205 by contacting the glass film 204 with the enzyme reaction sheet 205 after the enzyme reaches the non-blood cell adsorption region ar2. Can be shortened. Therefore, the reagent 202 in the enzyme reaction sheet 205 is unlikely to flow out to the glass film 204. Therefore, the reaction between the enzyme and the enzyme reaction sheet 205 becomes sufficient, and the absorbance of the enzyme can be measured with high accuracy.

In addition, the controlled component may include amylase.

As a result, the drain drainage management system 5 can measure information on amylase, which is a digestive enzyme (absorbance of amylase, change in amylase absorbance, amylase activity, concentration of amylase, etc.) and generate measurement data.

In addition, the controlled component may contain bilirubin.

As a result, the drain drainage management system 5 can measure information about bilirubin, which is a bile pigment (absorbance of bilirubin, concentration of bilirubin, etc.), and can generate measurement data.

Further, the glass membrane 204 is formed by bundling glass fibers into a sheet shape, and may be used as an example of a blood cell separation membrane.

As a result, the drain drainage management system 5 can suppress the inability to sufficiently acquire non-blood cells due to the smaller pores of the monolith membrane as compared with the monolith membrane by using the glass membrane 204 as the blood cell separation membrane, and the measurement can be performed. It is possible to secure a necessary and sufficient amount of non-blood cells for this purpose. Further, in the drain drainage management system 5, by using the glass film 204 as the blood cell separation membrane, since there are no holes like the cellulose film, it is possible to suppress the passage of both blood cells and non-blood cells, and the capillary phenomenon of the glass fiber. Therefore, blood cells and non-blood cells can be suitably separated. Further, the drain drainage management system 5 can easily handle the glass film 204 in the same manner as the non-woven fabric by using the glass film 204 formed by bundling the glass fibers into a sheet shape.

The measurement data may include information on the amount of drainage drained per unit time.

Thereby, the drainage drainage management system 5 can evaluate the drainage amount per unit time of the drainage drainage and appropriately evaluate the recovery tendency of the patient. Further, the drainage drainage management system 5 can perform a more appropriate evaluation by examining the correlation between the drainage drainage amount and other information depending on the content of the operation performed by the patient.

The measurement data may include information about the total drainage drainage.

Thereby, the drain drainage management system 5 can evaluate the total drainage amount of the drainage drainage (for example, the total drainage amount from the start of use of the drain tube 30 to the present time), and can appropriately evaluate the recovery tendency of the patient. Further, the drainage drainage management system 5 can perform a more appropriate evaluation by examining the correlation between the total drainage amount of the drainage drainage and other information, depending on the content of the operation performed by the patient.

The drainage drainage management system 5 may include a memory 27 (an example of a registration unit) for registering a part or all of the data and at least one of the time series data in the electronic medical record.

This allows a plurality of users to share information on the patient's recovery tendency via an electronic medical record. In other words, multiple people can assess the patient's drainage status. As a result, it is possible to perform an objective and appropriate evaluation as compared with the case where the user evaluates by himself / herself. The drainage drainage management system 5 accumulates measurement data related to drainage drainage and time-series data related to the measurement data in order to enable such evaluation of the state of drainage drainage by a plurality of people, and supports evaluation by the user. can.

The drainage sampling mechanism 110 is a range and a range between two points in the main tube 130 (an example of the main flow path), the sub tube 133 branched from the main tube 130 (an example of the sub flow path), and the sub tube 133. The two limiting members 113 and 114 that restrict the flow of drainage liquid to and from the outside, and the main tube 130 that presses the main tube 130 between the two points in a state where the flow of drainage liquid is restricted in the main tube 130. 1 Pressing member 115 may be provided. The sub-tube 133 does not have to pass the drain drainage from the main tube 130 when pressed by the first pressing member 115, and does not have to pass the drain drainage from the main tube 130 when not pressed by the first pressing member 115. ..

As a result, the drainage drainage management system 5 can sample the drainage drainage with a simple configuration, and can have the drainage drainage sampling mechanism 110 which is excellent in portability and easy to carry. Therefore, the patient does not have to stay in a fixed position at the time of sampling, and the degree of freedom of the user at the time of sampling is improved. Further, the drain drainage management system 5 can stabilize the amount of drainage drainage existing between the two points by keeping the distance between the two points in the main tube 130 invariant at the time of measurement. The amount of drainage drainage is the amount of one sampling. Further, the drain drainage management system 5 allows the drainage drainage to pass when pressed by the first pressing member 115 and does not pass through the drainage drainage when not pressed by the first pressing member 115, so that one pressing can be performed once. It is possible to drain the drainage of the sampling amount of. Therefore, it is possible to prevent the liquid from remaining in the sub tube 133. Therefore, the drain drainage management system 5 can suppress the drainage drainage from being mixed with the previous amount in each sampling, and can derive measurement data with high measurement accuracy according to the sampling timing.

Further, in the above embodiment, the drain drainage sensor 10 (an example of a liquid discharge device) for sampling the drainage drainage (an example of a liquid) has a main tube 130 (an example of a main flow path) and a sub branched from the main tube 130. The tube 133 (an example of a secondary flow path), the two limiting members 113, 114 that limit the flow of drainage fluid between the range between the two points in the sub tube 133 and the outside of this range, and the main tube 130. A first pressing member 115 that presses the main tube 130 between two points may be provided in a state where the flow of drainage liquid is restricted. The sub-tube 133 does not have to pass the liquid from the main tube 130 when pressed by the first pressing member 115, and does not have to pass the liquid from the main tube 130 when not pressed by the first pressing member 115. Sampling may be an example of ejection.

As a result, the drain drainage sensor 10 can sample the drainage drainage with a simple configuration, is excellent in portability, and is easy to carry. Therefore, the patient does not have to stay in a fixed position at the time of sampling, and the degree of freedom of the user at the time of sampling is improved. Further, the drain drainage sensor 10 can stabilize the amount of drainage drainage existing between the two points by keeping the distance between the two points in the main tube 130 invariant at the time of measurement. The amount of drainage drainage is the amount of one sampling. Further, the drain drainage management system 5 allows the drainage drainage to pass when pressed by the first pressing member 115 and does not pass through the drainage drainage when not pressed by the first pressing member 115, so that one pressing can be performed once. It is possible to drain the drainage of the sampling amount of. Therefore, it is possible to prevent the liquid from remaining in the sub tube 133. Therefore, the drain drainage sensor 10 can suppress the drainage drainage from being mixed with the previous amount in each sampling, and can derive measurement data with high measurement accuracy according to the sampling timing.

As described above, the drain drainage sensor 10 is excellent in portability and can suppress the liquid from remaining in the sub tube 133 after sampling.

The limiting force by the limiting members 113 and 114 may be a force capable of maintaining the liquid flow restriction in the main tube 130 even when pressed by the first pressing member 115. The pressing force by the first pressing member 115 may be a force that allows the sub tube 133 to pass through the liquid.

As a result, the drain drainage sensor 10 can sample the drainage drainage in a state where the flow of the drainage is restricted by the limiting members 113 and 114, and the drainage drainage outflow to the outside of two points in the main tube 130 and two points. The inflow of drainage from the outside of the can be suppressed. Therefore, the drain drainage sensor 10 can keep the sampling amount at one time constant, and can improve the quantitativeness. Further, in the drain drainage sensor 10, the sub tube 133 can pass the liquid by pressing the first pressing member 115, and the sampling amount at one time can be extracted through the sub tube 133.

The opening area of the connection position where the main tube 130 and the sub tube 133 are connected in the sub tube 133 may be larger than the cross-sectional area (flow path cross-sectional area) of the flow path 133z in the sub tube 133.

Thereby, the drain drainage sensor 10 can prevent the drainage drainage, which may contain various tissue pieces as well as the tissue pulverized liquid, from being clogged near the inlet of the sub tube 133. Therefore, the drain drainage sensor 10 is a sub. The drain drainage can be easily entered from the inlet of the tube 133, the drain drainage can be guided into the flow path 133z whose area is smaller than the opening area of the connection position, and the drain drainage can be sent out through the flow path 133z. It can be done easily. Therefore, the drainage drainage sensor 10 can stabilize the sampling amount at one time and improve the quantitativeness even when sampling the drainage drainage containing a large amount of tissue pieces or a relatively large piece of tissue, for example.

The drain drainage sensor 10 may be configured so that the pressing by the first pressing member 115 is released after the restriction by the limiting members 113 and 114 is released.

As a result, the drain drainage sensor 10 can guide the drainage drainage sent out in the next sampling between the two points in the main tube 130 by releasing the restriction by the limiting members 113 and 114. The drain drainage sensor 10 is ready to flow new drainage drainage toward the sub-tube 133 side in the next sampling by releasing the pressing by the first pressing member 115. Further, when the pressing by the first pressing member 115 is released, the restriction by the limiting members 113 and 114 has already been released, so that between the two points in the main tube 130 according to the release of the pressing by the first pressing member 115. It is possible to suppress the decrease in pressure. Therefore, it is possible to prevent the drainage drainage that has been pressed and moved to the sub tube 133 from flowing back to the main tube 130 side again. Therefore, in the drain drainage sensor 10, the amount of drainage drainage delivered by one sampling operation (one pressing operation by the first pressing member 115) is caused by the release of the pressing by the first pressing member 115. It can suppress the change. Therefore, the drain drainage sensor 10 can suppress a decrease in the quantitativeness of the sampling amount.

The drainage sampling mechanism 110 may be configured such that the limitation and the release of the limitation by the limiting members 113 and 114 and the pressing and the release of the pressing by the first pressing member 115 are repeatedly performed.

As a result, the drainage drainage sensor 10 can continuously sample the drainage drainage. The drain drainage sensor 10 automatically samples periodically once an hour, etc. by limiting and releasing the limitation by the limiting members 113 and 114, and pressing and releasing the pressing by the first pressing member 115. The liquid can be obtained.

The limiting members 113, 114 may press two points on the main tube 130 to limit the flow of drain liquid between the range between the two points and the outside of this range.

As a result, the drain drainage sensor 10 can limit the flow of drainage drainage by a simple operation of pressing two points on the main tube 130.

Further, the distance between the two points on the main tube 130 may be adjustable.

This makes it possible to easily change the sampling amount. Therefore, the drain drainage sensor 10 can be used as a controlled component (for example, amylase) to be measured even if the sampling amount required for measuring the controlled component is different for each controlled component (for example, blood, amylase, bilirubin). The interval between the two points may be adjusted so that the desired sampling amount can be obtained. Further, the interval between the two points may be predetermined or may be dynamically changed. For example, the position where the limiting members 113 and 114 press the main tube 130 by a motor or the like may be moved along the direction in which the main tube 130 extends. For example, in the drain drainage sensor 10, the CPU 181 acquires the sampling amount required for the measurement of the controlled component from the memory or the like by inputting the information of the controlled component via the operation unit (not shown), and samples the sample. The interval between the two points may be adjusted according to the amount.

Further, the drainage drainage sensor 10 may include a blood cell separation / enzyme reaction mechanism 150 (an example of an analysis unit) that analyzes the drainage liquid that has passed through the subtube 133.

As a result, the drainage drainage sensor 10 can consistently perform sampling to analysis of the drainage drainage. Therefore, the drainage drainage sensor 10 can be carried by the patient and can also perform an analysis of drainage drainage. Therefore, the drain drainage sensor 10 can automatically grasp the patient's condition while improving the degree of freedom of the patient. Further, the drainage drainage sensor 10 can shorten the time required from sampling of drainage drainage to analysis as compared with the case where sampling and analysis of drainage drainage are performed by separate devices.

Further, the main tube 130 may be connected to the drain tube 30 through which the drainage liquid discharged from the living body flows. Drain drainage may be used as an example of a liquid.

As a result, the drainage drainage sensor 10 can easily sample the drainage drainage discharged from the living body. Further, a liquid other than the drainage liquid may be sampled. In this case, the drain drainage sensor 10 can analyze the state of the sampled liquid.

Also, drainage may include blood cells and non-blood cells. The blood cell separation / enzyme reaction mechanism 150 includes a glass membrane 204 (an example of a blood cell separation membrane) that separates blood cells and non-blood cells from drainage fluid, and the state of the non-blood cells separated by the glass membrane 204 may be measured. ..

As a result, by using the glass film 204, the drain drainage sensor 10 can suppress the measurement of a mixture of blood cell components having different characteristics when measuring the state of non-blood cells. Therefore, the drain drainage sensor 10 can improve the measurement accuracy of the non-blood cell component. Therefore, the drainage drainage sensor 10 can objectively evaluate the state of non-blood cells contained in the drainage drainage while improving the measurement accuracy of the non-blood cell component. Further, since the drain drainage sensor 10 can separate blood cells and non-blood cells by membrane separation, it is not necessary to use a centrifuge, and the drain drainage sensor 10 that separates blood cells and non-blood cells is miniaturized and low in cost. It is possible to change.

Further, the blood cell separation / enzyme reaction mechanism 150 includes an enzyme reaction sheet 205 that reacts with the enzyme contained in the non-blood cells separated by the glass film 204, and the enzyme reaction sheet 205 may measure the absorbance of the reacted enzyme.

As a result, the drain drainage sensor 10 can color the enzyme using the enzyme reaction sheet 205 even when the colorless enzyme is a controlled component. Therefore, when the colored enzyme is irradiated with the measurement light, the enzyme in the enzyme reaction sheet 205 can scatter the measurement light, and the photosensor 183 can receive the scattered light. Therefore, the drain drainage sensor 10 can measure the absorbance of the enzyme even when the colorless enzyme is a controlled component, and can derive the concentration of the enzyme based on the absorbance.

Further, the blood cell separation / enzyme reaction mechanism 150 includes a glass film 204, an enzyme reaction sheet 205, and a spacer 203 having a hole 203z (an example of an opening) and arranged between the glass film 204 and the enzyme reaction sheet 205. The measuring tape 200 having the A motor 175 (an example of a drive unit) for driving the 172 may be provided. The take-up reel 172 or the feed reel 171 may take up or send out the measuring tape 200 by driving the motor 175.

As a result, the drain drainage sensor 10 can separate the glass film 204 and the enzyme reaction sheet 205 via the spacer 203. Therefore, the drain drainage sensor 10 can suppress the diffusion of the reagent 202 of the enzyme reaction sheet 205 onto the glass film 204 due to the long contact time between the enzyme reaction sheet 205 and the glass film 204. Further, since the measuring tape 200 is held in the feed reel 171 or the take-up reel 172, the measuring tape 200 is sent out when necessary, so that the measuring tape 200 can be used in the measurement of the enzyme. Further, by sending out the measuring tape 200 by the driving force of the motor 175, the desired position of the measuring tape 200 can be adjusted so as to face the outlet of the sub tube 133. Therefore, the glass film 204 in the measuring tape 200 can receive the sampling liquid sq from the sub tube 133 at a desired position. Further, by continuously driving the motor 175, the sampling liquid sq containing the enzyme can be continuously obtained, and the absorbance of the enzyme can be measured.

The blood cell separation / enzyme reaction mechanism 150 may include a second pressing member 116. The second pressing member 116 pressed the measuring tape 200 at a position where the hole 203z of the spacer 203 in the measuring tape 200 and the second pressing member 116 face each other, and was separated by the glass film 204 in the measuring tape 200. The enzyme may be brought into contact with the enzyme reaction sheet 205.

In the drain drainage sensor 10, the acquired drainage drainage is separated by the glass film 204, and the enzyme as a non-blood cell moves to a position facing the hole 203z in the glass film 204. When the glass film 204 is pressed by the second pressing member 116 at the position where the enzyme has moved, the region of the glass film 204 containing the enzyme and the enzyme reaction sheet 205 come into contact with each other via the spacer 203. Therefore, after the transfer of the enzyme, the enzyme comes into contact with the enzyme reaction sheet 205, and the enzyme adsorbed on the non-hemadsorbent region ar2 can be transferred to the enzyme reaction sheet 205 as in the transcription method. Therefore, it is possible to prevent the reagent 202 contained in the enzyme reaction sheet 205 from moving to the outside without reacting with the enzyme, resulting in insufficient coloring of the enzyme. Therefore, the drain drainage sensor 10 can suppress a decrease in the measurement accuracy of the absorbance of the enzyme, and can suppress a decrease in the measurement accuracy of the state of the enzyme.

Further, in the above embodiment, the measurement tape 200 includes a glass film 204 (an example of a blood cell separation membrane) that separates blood cells and non-blood cells from drainage fluid that is discharged from a living body and contains blood cells and non-blood cells, and glass. An enzyme reaction sheet 205 that reacts with an enzyme contained in a non-blood cell separated by a membrane 204, and a spacer 203 having a pore 203z (an example of an opening) and arranged between the glass film 204 and the enzyme reaction sheet 205. May have.

As a result, the measuring tape 200 can separate the glass film 204 and the enzyme reaction sheet 205 via the spacer 203. The measuring tape 200 can suppress the diffusion of the reagent 202 of the enzyme reaction sheet 205 onto the glass film 204 due to the long contact time between the enzyme reaction sheet 205 and the glass film 204. Further, the measuring tape 200 has the hole 203z in a part of the spacer 203, so that the glass film 204 and the enzyme reaction sheet 205 are brought into contact with each other via the hole 203z by using an external force such as pressing. The enzyme on the glass film 204 can be reacted with the reagent 202 contained in the enzyme reaction sheet 205 when necessary. Therefore, the measuring tape 200 can assist various analyzes (for example, measurement of absorbance) using an enzyme that has reacted with the reagent 202.

INDUSTRIAL APPLICABILITY The present invention is useful for a liquid discharge device, a measuring tape, and the like, which are excellent in portability and can suppress the liquid from remaining in the flow path after sampling.

5 Drain drainage management system 10 Drain drainage sensor 10A TCI pump 10z chassis 10y through hole 20 drain drainage monitor 20z chassis 21 display 22 graph 23 description 24 meters 25 status marker 26 CPU
27 Memory 28 Wireless chip 30 Drain tube 30A Dosing tube 40 Drain bag 41 Inflow tube 110 Drainage sampling mechanism 113, 114 Limiting member 113A, 114A, 115A, 116A Pressurizing unit 113B, 114B Partition plate 115 First pressing member 115B Pressing plate 116 2nd pressing member 116B Tip 130 Main tube 130c Tube center 133 Sub tube 133b Opening 133z Flow path 140 3rd pressing member 141 1st pressing part 142 2nd pressing part 143 Rotation axis 150 Blood cell separation / enzyme reaction mechanism 171 Feed reel 172 Take-up reel 175 Motor 176, 177 Roller 180 Sensor unit 180z Housing 181 CPU
182 LED
183 Photosensor 184 Wireless chip 185 Battery 186 Pressurization unit drive unit 187 Motor drive unit 188 Circuit board 200, 200A, 200B Measurement tape 201, 201A, 201B PET sheet 202, 202B Reagent 203, 203B Spacer 204, 204A, 204B Glass Membrane 205,205B Enzyme reaction sheet 300 Homogenizer 310 Container ar1 Blood cell adsorption area ar2 Non-blood cell adsorption area AS1 Area with 4-layer structure AS2 Area with 2-layer structure ba Blood cells g1, g11, g12, g21, g22, g31 Graph L1, L2 Broken line Lq Drain drainage Lq1 Mouse tissue crushing solution ms1 Mouse mz Tissue piece P1 Pressing pressure P Internal pressure P2 Opening force or resistance PA1 Patient rz Amylase sp1 Intestinal tissue sq, sq1, sq2 Sampling solution ws1 Physiological saline

Claims (12)

A liquid discharge device that discharges liquid.
Main flow path and
The sub-flow path branched from the main flow path and
Two limiting members that limit the flow of the liquid between the range between the two points in the main flow path and the outside of the range so that the liquid temporarily stops flowing.
In the primary flow passage, the flow of said liquid, in a state where the liquid is restricted to be not temporarily flows, the first pressing member for pressing the main flow path between the two points,
Equipped with
When pressed by the first pressing member, the sub-flow path allows the liquid from the main flow path to pass through, and when not pressed by the first pressing member, the sub-flow path does not allow the liquid from the main flow path to pass through.
The limiting force by the limiting member is a force capable of maintaining the flow restriction of the liquid in the main flow path even when pressed by the first pressing member.
The pressing force by the first pressing member is a force that allows the auxiliary flow path to pass through the liquid.
Liquid discharge device. The liquid discharge device according to claim 1.
The opening area of the connection position where the main flow path and the sub flow path are connected in the sub flow path is larger than the flow path cross-sectional area in the sub flow path.
Liquid discharge device. The liquid discharge device according to claim 1.
After the restriction by the limiting member is released, the pressing by the first pressing member is released.
Liquid discharge device. The liquid discharge device according to claim 1.
The restriction and release of the restriction by the limiting member and the pressing and releasing of the pressing by the first pressing member are configured to be repeated.
Liquid discharge device. The liquid discharge device according to any one of claims 1 to 4.
The limiting member presses the two points in the main flow path and limits the flow of the liquid between the range between the two points and the outside of the range.
Liquid discharge device. The liquid discharge device according to any one of claims 1 to 5.
The distance between the two points in the main flow path is adjustable.
Liquid discharge device. The liquid discharge device according to any one of claims 1 to 6, further comprising:
An analysis unit for analyzing the liquid that has passed through the subchannel is provided.
Liquid discharge device. The liquid discharge device according to claim 7.
The liquid is drainage discharged from the living body, and is
The main flow path is connected to a drain tube through which the drainage fluid flows.
Liquid discharge device. The liquid discharge device according to claim 8.
The drainage contains blood cells and non-blood cells.
The analysis unit includes a blood cell separation membrane that separates the blood cells and the non-blood cells from the drainage, and measures the state of the non-blood cells separated by the blood cell separation membrane.
Liquid discharge device. The liquid discharge device according to claim 9.
The analysis unit includes an enzyme reaction sheet that reacts with an enzyme contained in the non-blood cells separated by the blood cell separation membrane, and measures the absorbance of the enzyme reacted by the enzyme reaction sheet.
Liquid discharge device. The liquid discharge device according to claim 10.
The analysis unit
A measuring tape having the blood cell separation membrane, the enzyme reaction sheet, and a spacer having an opening and arranged between the blood cell separation membrane and the enzyme reaction sheet.
The winding member that winds up the measuring tape and
Each time the absorbance of the enzyme is measured, the drive unit that drives the take-up member and the drive unit
Equipped with
The take-up member winds up or sends out the measurement tape by driving the drive unit.
Liquid discharge device. The liquid discharge device according to claim 11.
The analysis unit
Equipped with a second pressing member
The second pressing member presses the measuring tape at a position where the opening of the spacer in the measuring tape and the second pressing member face each other, and is separated by the blood cell separation membrane in the measuring tape. The enzyme and the enzyme reaction sheet are brought into contact with each other.
Liquid discharge device.

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