JP6918394B1 - Biological information calculation system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a biometric information calculation system capable of generating information on a user's motor ability with high accuracy. SOLUTION: The evaluation data is different from the acquisition means for acquiring the evaluation data based on the pulse wave of the user, the database, and the generation means for generating the blood information including the characteristics related to the composition of the blood with respect to the evaluation data by referring to the database. It is characterized by comprising an evaluation means for generating an evaluation result showing a tendency of a user's athletic ability based on a plurality of blood information generated from the data. In the database, a pair of input data based on the learning pulse wave acquired in advance and reference data including features related to blood composition associated with the input data are used as training data, and are generated using a plurality of training data. Classification information is stored. [Selection diagram] Fig. 1

Description

The present invention relates to a biometric information calculation system that calculates a user's blood glucose level.

Conventionally, as a method of calculating a user's blood glucose level, for example, a method as in Patent Document 1 has been proposed.

The non-invasive blood glucose level measuring device disclosed in Patent Document 1 has a predetermined correlation from a pulse wave measuring unit provided with an FBG sensor for measuring an acceleration pulse wave of a subject and waveform information of the measured acceleration pulse wave. Based on the above, the data processing unit for calculating the blood glucose level of the subject at the time of measuring the acceleration pulse wave is provided. The correlation is a calibration curve constructed by performing PLS regression analysis using the blood glucose level measured by the invasive measurement method as the objective variable and the acceleration pulse wave measured at the same time as the explanatory variable.

Japanese Patent No. 6544751

Here, as an example of an index for evaluating the health condition of a user, the degree of blood glucose spike indicating a rapid change in blood glucose level can be mentioned. Blood glucose spikes are known as a characteristic peculiar to the diabetic reserve army, but the timing and degree of occurrence of blood glucose spikes vary from person to person, and it is difficult to quantitatively evaluate them. In addition, since diabetic patients tend to have high blood glucose levels at all times, the blood glucose levels are similar to those at the time of the occurrence of blood glucose spikes. For these reasons, it is difficult to classify whether the blood glucose level arbitrarily measured by the user is the value at the time of occurrence of the blood glucose spike or the value peculiar to the diabetic patient, and the user belongs to either the diabetic reserve army or the diabetic patient. There is a risk that the judgment will include subjectivity. Therefore, it is desired to realize a quantitative evaluation of changes in blood glucose level.

In this respect, the disclosure technique of Patent Document 1 is limited to the disclosure of a technique capable of calculating the blood glucose level in a non-invasive manner, and it is difficult to link to the discovery and solution of the above-mentioned problems related to changes in the blood glucose level.

Therefore, the present invention has been devised in view of the above-mentioned problems, and an object of the present invention is to provide a biometric information calculation system capable of realizing a quantitative evaluation of changes in blood glucose level. It is in.

The biometric information calculation system according to the first invention is a biometric information calculation system that calculates a user's blood glucose level, and is an acquisition means for acquiring evaluation data based on the user's pulse wave and a learning pulse wave acquired in advance. A database in which classification information generated using a plurality of the training data is stored and the database are used as training data using a pair of input data based on the above and reference data including a blood glucose level associated with the input data. It includes a calculation means for calculating the user's blood glucose level with respect to the evaluation data, and blood glucose spike information indicating a change in the user's blood glucose level based on a plurality of the blood glucose levels calculated from the different evaluation data. It is characterized by comprising an evaluation means for generating an evaluation result.

The biological information calculation system according to the second invention is characterized in that, in the first invention, the evaluation means calculates the blood glucose spike information from time-series changes in a plurality of the blood glucose levels and generates the evaluation result. ..

In the first invention, the biometric information calculation system according to the third invention acquires additional information indicating the characteristics of the user's biometric information, and evaluates the health condition of the user based on the evaluation result and the additional information. It is characterized by providing a comprehensive evaluation means for generating an evaluation result.

In the first invention, the biometric information calculation system according to the fourth invention obtains additional information indicating the characteristics of the user's biometric information, refers to the database, and uses the evaluation data and the additional information. Based on this, it is characterized by including calculating the blood glucose level.

In the third or fourth invention, the biometric information calculation system according to the fifth invention includes the acquisition means for acquiring additional data showing characteristics different from the evaluation data based on the pulse wave. The calculation means includes generating the additional information based on the additional data.

The biometric information calculation system according to the sixth invention is the biometric information calculation system according to any one of the third to fifth inventions, wherein the additional information includes pulse rate, respiratory rate, blood pressure, lactic acid level, characteristics of blood carbon dioxide, oxygen saturation, and so on. It is characterized by indicating at least one of vascular age, stress level, and degree of diabetes.

In the first invention, the biometric information calculation system according to the seventh invention includes that the acquisition means acquires additional data showing characteristics different from the evaluation data based on the pulse wave, and the calculation means includes the acquisition of additional data showing characteristics different from the evaluation data. It is characterized by referring to the database and generating additional information indicating the characteristics of the user's biometric information with respect to the additional data.

In the first invention, the biometric information calculation system according to the eighth aspect of the present invention obtains additional information indicating the characteristics of the biometric information of the user, and evaluates the evaluation means based on the plurality of blood glucose levels and the additional information. It is characterized by including producing a result.

In the first invention, the biometric information calculation system according to the ninth invention includes that the acquisition means acquires preliminary evaluation data different from the evaluation data based on the pulse wave, and the classification information is different from each other. A selection means that includes a plurality of attribute-based classification information calculated using the learning data, the calculation means refers to the preliminary evaluation data, and selects the first classification information from the plurality of attribute-based classification information. And the attribute-specific calculation means for calculating the blood glucose level with respect to the evaluation data with reference to the first classification information.

In the ninth invention, the biological information calculation system according to the tenth invention acquires data corresponding to a velocity pulse wave based on the pulse wave as the evaluation data, and the acceleration pulse wave based on the pulse wave. It is characterized in that the data corresponding to is acquired as the preliminary evaluation data.

In the first invention, the biometric information calculation system according to the eleventh invention acquires additional information indicating the characteristics of the user's biometric information, and the first classification of the classification information is based on the additional information. It is characterized by including selecting information, referring to the first classification information, and calculating the blood glucose level with respect to the evaluation data.

According to the first to eleventh inventions, the calculation means calculates the blood glucose level of the user with respect to the evaluation data. The evaluation means generates an evaluation result including blood glucose spike information indicating a change in the user's blood glucose level based on a plurality of blood glucose levels calculated from different evaluation data. Therefore, it is possible to obtain an evaluation result for a change in blood glucose level regardless of individual differences of users. This makes it possible to realize a quantitative evaluation of changes in blood glucose level.

Further, according to the first to eleventh inventions, the calculation means refers to the database and calculates the blood glucose level of the user with respect to the evaluation data. In addition, the database stores classification information generated using a plurality of learning data. Therefore, when calculating the blood glucose level, it is possible to calculate the quantitative blood glucose level based on the data that has been proven in the past. This makes it possible to improve the accuracy when calculating the blood glucose level.

In particular, according to the second invention, the evaluation means calculates blood glucose spike information from time-series changes in a plurality of blood glucose levels and generates an evaluation result. Therefore, it is possible to generate an evaluation result in consideration of not only the intensity of blood glucose spikes but also the characteristics of the shape. This makes it possible to improve the accuracy of evaluation regarding changes in blood glucose level.

In particular, according to the third invention, the comprehensive evaluation means generates a comprehensive evaluation result for evaluating the health condition of the user based on the evaluation result and additional information. Therefore, in addition to the evaluation result, it is possible to realize a comprehensive evaluation considering the characteristics of the user. This makes it possible to evaluate the health condition based on the change in the blood glucose level of the user.

In particular, according to the fourth invention, the calculation means refers to the database and calculates the blood glucose level based on the evaluation data and the additional information. Therefore, an effective parameter can be used when calculating the blood glucose level of the user. This makes it possible to further improve the accuracy when calculating the blood glucose level.

In particular, according to the fifth invention, the acquisition means acquires additional data showing features different from the evaluation data based on the pulse wave. Further, the calculation means generates additional information based on the additional data. That is, the evaluation result and additional information are generated based on one pulse wave. Therefore, by using a plurality of types of information based on the same parameter, it is possible to realize comprehensive calculation and evaluation from various viewpoints.

In particular, according to the sixth invention, the additional information includes at least one of pulse rate, respiratory rate, blood pressure, lactic acid level, characteristics of blood carbon dioxide, oxygen saturation, blood vessel age, stress level, and degree of diabetes. show. Therefore, it is possible to perform an evaluation based on a plurality of biological information. This makes it possible to improve the evaluation accuracy.

In particular, according to the seventh invention, the calculation means refers to the database and generates additional information indicating the characteristics of the user's biological information with respect to the additional data. Therefore, additional information generated from a viewpoint different from the blood glucose level can be used, and a multifaceted evaluation can be realized. This makes it possible to realize an appropriate evaluation according to the user's request.

In particular, according to the eighth invention, the evaluation means includes acquiring additional information and generating an evaluation result based on a plurality of blood glucose levels and the additional information. Therefore, in addition to the blood glucose level, it is possible to generate a multifaceted evaluation result in consideration of the characteristics of the user.

In particular, according to the ninth invention, the calculation means refers to the preliminary evaluation data and selects the first classification information, and the first classification information is referred to to calculate the blood glucose level for the evaluation data by attribute. Including means. Therefore, it is possible to calculate the blood glucose level for the evaluation data after selecting the optimum attribute classification information for the characteristics of the pulse wave. This makes it possible to further improve the evaluation accuracy.

In particular, according to the tenth invention, the acquisition means acquires the data corresponding to the velocity pulse wave based on the pulse wave as evaluation data, and acquires the data corresponding to the acceleration pulse wave based on the pulse wave as preliminary evaluation data. do. Therefore, the attribute classification information can be selected by using the acceleration pulse wave, which makes it easier to classify the characteristics of the pulse wave than the velocity pulse wave. Further, the blood glucose level can be calculated by using the velocity pulse wave, which is easier to calculate the blood glucose level than the acceleration pulse wave. This makes it possible to further improve the evaluation accuracy.

In particular, according to the eleventh invention, the calculation means includes referring to the first classification information selected based on the additional information and calculating the blood glucose level with respect to the evaluation data. Therefore, it is possible to calculate the blood glucose level for the evaluation data after selecting the most suitable classification information for the characteristics of the user. This makes it possible to further improve the evaluation accuracy.

FIG. 1 is a schematic diagram showing an example of a biological information calculation system according to the first embodiment. 2 (a) and 2 (b) are schematic views showing an example of the operation of the biometric information calculation system according to the first embodiment. FIG. 3A is a schematic diagram showing an example of classification information, and FIGS. 3B and 3C are schematic diagrams showing an example of processing for sensor data. FIG. 4A is a schematic diagram showing an example of the configuration of the biological information arithmetic unit, and FIG. 4B is a schematic diagram showing an example of the function of the biological information arithmetic unit. 5 (a) and 5 (b) are schematic views showing an example of the sensor. FIG. 6 is a flowchart showing an example of the operation of the biometric information calculation system according to the first embodiment. FIG. 7 is a schematic diagram showing an example of the operation of the biometric information calculation system according to the second embodiment. FIG. 8 is a schematic diagram showing a modified example of the operation of the biological information calculation system according to the second embodiment. FIG. 9 is a schematic diagram showing an example of the operation of the biometric information calculation system according to the third embodiment. 10 (a) and 10 (b) are schematic views showing an example of processing for calculating additional information with respect to the sensor data. FIG. 11 is a schematic diagram showing an example of the operation of the biometric information calculation system according to the third embodiment. FIG. 12 is a schematic diagram showing an example of the operation of the biometric information calculation system according to the fourth embodiment. FIG. 13 is a schematic diagram showing an example of the operation of the biometric information calculation system according to the fifth embodiment. FIG. 14 is a schematic diagram showing a classification example of data corresponding to an acceleration pulse wave. FIG. 15 is a schematic diagram showing a classification example of data corresponding to a velocity pulse wave. FIG. 16 is a schematic view showing a modified example of the operation of the biological information calculation system according to the fifth embodiment.

Hereinafter, an example of the biological information calculation system according to the embodiment of the present invention will be described with reference to the drawings.

(First Embodiment: Biometric information calculation system 100)
FIG. 1 is a schematic diagram showing an example of the biometric information calculation system 100 according to the first embodiment.

The biological information calculation system 100 is used to calculate the blood glucose level of the user. In particular, the biological information calculation system 100 can evaluate changes in the blood glucose level of the user based on the calculated plurality of blood glucose levels.

The change in the user's blood glucose level can be indicated by, for example, blood glucose spike information. The blood glucose spike information indicates, for example, an average value for a plurality of blood glucose levels, a range of values (for example, the intensity of the blood glucose spike indicated by the difference between the maximum value and the minimum value), a median value, and the like.

In addition to the above, the blood glucose spike information indicates, for example, a value obtained from a time-series change in a plurality of blood glucose levels, for example, a characteristic of time change derived using differentiation and a characteristic of peak shape derived using integration. Is shown. The term "blood glucose spike" includes a known definition indicating a change in blood glucose level.

The biological information calculation system 100 can generate an evaluation result including the above-mentioned blood glucose spike information. The evaluation result may include, for example, the health condition evaluated based on the blood glucose spike information, in addition to the numerical values and features indicated by the blood glucose spike information.

As shown in FIG. 1, the biometric information calculation system 100 may include a biometric information calculation device 1, for example, at least one of a sensor 5 and a server 4. The biological information arithmetic unit 1 is connected to the sensor 5 and the server 4 via, for example, a communication network 3.

The biological information calculation system 100 calculates the blood glucose level from the evaluation data based on the pulse wave of the user. Further, the biological information calculation system 100 generates an evaluation result including blood glucose spike information based on, for example, a plurality of blood glucose levels generated in a time series or at an arbitrary timing.

In the biometric information calculation system 100, for example, as shown in FIG. 2A, the biometric information calculation device 1 acquires the sensor data generated by the sensor 5 or the like. After that, the biometric information calculation device 1 performs preprocessing such as filter processing on the acquired sensor data, and acquires evaluation data.

The biological information calculation device 1 calculates the blood glucose level with respect to the evaluation data. After that, the biometric information calculation device 1 generates an evaluation result based on a plurality of blood glucose levels generated from different evaluation data. Therefore, it is possible to obtain an evaluation result for a change in blood glucose level regardless of individual differences of users. This makes it possible to realize a quantitative evaluation of changes in blood glucose level.

Here, the biological information calculation device 1 refers to a database when calculating the blood glucose level with respect to the evaluation data. The database stores classification information generated using a plurality of learning data.

As the classification information, for example, as shown in FIG. 3A, a pair of input data based on the learning pulse wave acquired in the past and reference data including the past blood glucose level associated with the input data is used as the learning data. , Generated using multiple learning data. Therefore, when calculating the blood glucose level, it is possible to calculate the quantitative blood glucose level based on the input data and the output data that have been proven in the past. This makes it possible to improve the accuracy when calculating the blood glucose level.

The biological information arithmetic unit 1 outputs, for example, the generated evaluation result to a display or the like. The evaluation result includes blood glucose spike information indicating a change in the blood glucose level of the user, and includes, for example, numerically indicated blood glucose spike information. The evaluation result may include, for example, an index showing the possibility of diabetes, information on a recommended diet, and information on exercise.

In the biometric information calculation system 100, evaluation data may be acquired from the sensor 5 or the like, for example, as shown in FIG. 2B. In this case, the preprocessing for acquiring the evaluation data from the sensor data is performed by the sensor 5 or the like.

<Sensor data>
The sensor data includes data indicating the characteristics of the user's pulse wave, and may include, for example, data (noise) indicating characteristics other than the pulse wave. The sensor data is data showing the amplitude with respect to the measurement time, and by performing filter processing according to the application and the generation conditions of the sensor data, data corresponding to the acceleration pulse wave, the velocity pulse wave, etc. is acquired from the sensor data. be able to.

The sensor data can be generated by a known sensor such as a strain sensor, a gyro sensor, a photoelectric volume pulse wave (PPG) sensor, and a pressure sensor. The sensor data may be, for example, an analog signal as well as a digital signal. The measurement time when generating the sensor data is, for example, the measurement time for 1 to 20 cycles of the pulse wave, and can be arbitrarily set according to the conditions such as the sensor data processing method and the data communication method. Can be done.

<Evaluation data>
The evaluation data shows data for calculating the blood glucose level. The evaluation data shows, for example, data corresponding to an acceleration pulse wave based on a user's pulse wave, and shows an amplitude with respect to a specific period (for example, one period).

The evaluation data is acquired by processing (preprocessing) the sensor data by the biometric information calculation device 1 or the like. For example, as shown in FIGS. 3 (b) and 3 (c), evaluation data can be obtained by performing a plurality of processes on the sensor data. Details of each process will be described later.

<Database>
The database is mainly used to calculate the user's blood glucose level with respect to the evaluation data. In addition to storing one or more classification information, the database may store, for example, a plurality of learning data used for generating the classification information.

The classification information is, for example, a function showing the interphase relationship between the past evaluation data (input data) acquired in advance and the reference data including the blood glucose level. The classification information shows, for example, a calibration model generated based on the analysis result of analysis by regression analysis or the like with the input data as the explanatory variable and the reference data as the objective variable. The classification information can be updated periodically, for example, and may include a plurality of calibration models generated for each attribute information such as the user's gender, age, and exercise content.

As a method of regression analysis used when generating classification information, for example, PLS (Partial Least Squares) regression analysis and SIMCA (Soft Independent Modeling of Class Analogy) method for obtaining a principal component model by performing principal component analysis for each class are used. Regression analysis and the like can be used.

The classification information may include, for example, a trained model generated by machine learning using a plurality of training data. The trained model shows, for example, a neural network model such as CNN (Convolutional Neural Network) and SVM (Support vector machine). Further, as machine learning, for example, deep learning can be used.

As the input data, the same type of data as the evaluation data is used, and for example, past evaluation data in which the corresponding blood glucose level is clarified is shown. For example, the subject is made to wear a sensor 5 or the like to generate sensor data (learning sensor data) showing the characteristics of the learning pulse wave. Then, the input data can be acquired by performing the processing on the learning sensor data. The input data may be acquired from the user of the biometric information calculation system 100, or may be acquired from a user other than the user, for example. That is, the above-mentioned subject may be a user of the biometric information calculation system 100, may be a target other than the user, and may be a specific or unspecified majority.

It is preferable that the input data is acquired according to the same contents as, for example, the type of the sensor 5 used when acquiring the evaluation data, the generation condition of the sensor data, and the processing condition for the sensor data. For example, by unifying the above three contents, it is possible to dramatically improve the accuracy when calculating the blood glucose level.

The reference data includes the blood glucose level of the subject measured using a measuring device or the like. For example, when a subject is equipped with a sensor 5 or the like to generate learning sensor data, the reference data associated with the input data can be acquired by measuring the blood glucose level of the subject. In this case, the timing of measuring the blood glucose level is preferably the same as the timing of generating the learning sensor data, but it may be, for example, about 1 to 10 minutes. As a measuring device for measuring the blood glucose level, for example, a known blood glucose meter such as Freestyle Precision Pro (manufactured by Abbott Japan Co., Ltd.) is used.

<Evaluation result>
The evaluation result includes blood glucose spike information indicating a change in the user's blood glucose level. The evaluation result may include, for example, a plurality of blood glucose levels, a difference value in a plurality of blood glucose levels, and a degree of deviation between the plurality of blood glucose levels and a preset threshold value. By outputting the evaluation result, it is possible to grasp the change in the blood glucose level of the user.

<Biological information arithmetic unit 1>
The biological information arithmetic unit 1 indicates an electronic device such as a personal computer (PC), a mobile phone, a smartphone, a tablet terminal, or a wearable terminal. Indicates the device. The biometric information calculation device 1 may include a sensor 5. Hereinafter, an example in which a PC is used as the biometric information calculation device 1 will be described.

FIG. 4A is a schematic diagram showing an example of the configuration of the biological information arithmetic unit 1, and FIG. 4B is a schematic diagram showing an example of the function of the biological information arithmetic unit 1.

As shown in FIG. 4A, for example, the biological information arithmetic unit 1 includes a housing 10, a CPU (Central Processing Unit) 101, a ROM (Read Only Memory) 102, a RAM (Random Access Memory) 103, and the like. A storage unit 104 and an I / F 105-107 are provided. Each configuration 101-107 is connected by an internal bus 110.

The CPU 101 controls the entire biometric information arithmetic unit 1. The ROM 102 stores the operation code of the CPU 101. The RAM 103 is a work area used during the operation of the CPU 101. The storage unit 104 stores various information such as a database and evaluation data. As the storage unit 104, for example, in addition to an HDD (Hard Disk Drive), a data storage device such as an SSD (Solid State Drive) is used. For example, the biometric information calculation device 1 may have a GPU (Graphics Processing Unit) (not shown).

The I / F 105 is an interface for transmitting and receiving various information to and from the server 4, the sensor 5, and the like as needed via the communication network 3. The I / F 106 is an interface for transmitting and receiving information to and from the input unit 108. For example, a keyboard is used as the input unit 108, and a user or the like of the biometric information calculation device 1 inputs various information, a control command of the biometric information calculation device 1, or the like via the input unit 108. The I / F 107 is an interface for transmitting and receiving various information to and from the display unit 109. The display unit 109 displays various information stored in the storage unit 104, evaluation results, and the like. A display is used as the display unit 109, and for example, in the case of a touch panel type, it is provided integrally with the input unit 108.

FIG. 4B is a schematic diagram showing an example of the function of the biological information arithmetic unit 1. The biological information calculation device 1 includes an acquisition unit 11, a calculation unit 12, an evaluation unit 13, an output unit 14, and a storage unit 15, and may include, for example, a learning unit 16. Each function shown in FIG. 4B is realized by the CPU 101 executing a program stored in the storage unit 104 or the like using the RAM 103 as a work area.

<Acquisition unit 11>
The acquisition unit 11 acquires evaluation data based on the user's pulse wave. The acquisition unit 11 acquires the evaluation data by, for example, acquiring the sensor data from the sensor 5 or the like and then performing processing on the sensor data.

As shown in FIG. 3B, for example, the acquisition unit 11 performs a filtering process (filter process) on the acquired sensor data. In the filtering process, for example, a bandpass filter of 0.5 to 5.0 Hz is used. As a result, the acquisition unit 11 extracts data (pulse wave data) corresponding to the user's pulse wave. The pulse wave data indicates, for example, data corresponding to a velocity pulse wave. The pulse wave data may indicate data corresponding to, for example, an acceleration pulse wave or a volumetric pulse wave, and can be arbitrarily set according to the type and application of the sensor. Further, the filter range of the bandpass filter can be arbitrarily set according to the intended use.

The acquisition unit 11 performs differential processing on, for example, pulse wave data. For example, when the differential processing is performed on the pulse wave data corresponding to the velocity pulse wave, the acquisition unit 11 acquires the data (differential data) corresponding to the acceleration pulse wave. In the differentiation process, the differentiation may be performed twice in addition to the one-time differentiation.

The acquisition unit 11 performs division processing on, for example, the differential data. In the division process, for example, the differential data corresponding to the acceleration pulse wave of a plurality of cycles is divided into the data (divided data) corresponding to the acceleration pulse wave of each cycle. Therefore, the acquisition unit 11 can acquire a plurality of divided data by, for example, performing differential processing on one differential data. In the division process, the differential data can be divided into arbitrary cycles (for example, positive multiples of the cycles) depending on the application.

For example, in the division process, the amount of data in each of the divided data may be different. In this case, the acquisition unit 11 may specify the divided data having the smallest amount of data and reduce (trim) the amount of data with respect to the other divided data. As a result, the amount of data in each divided data can be unified, and the data in each divided data can be easily compared.

In addition to the above, for example, standardization processing may be performed on values corresponding to the time axis of the divided data. In the standardization process, for example, standardization is carried out in which the minimum value corresponding to the time axis is set to 0 and the maximum value is set to 1. This facilitates the comparison of the data in each divided data.

The acquisition unit 11 may calculate, for example, the average of a plurality of divided data for which the amount of data has been reduced or standardized, and use the divided data as the divided data.

The acquisition unit 11 performs standardization processing on the divided data. In the standardization process, standardized data (normalized data) is generated for the values corresponding to the amplitude. In the normalization process, for example, standardization is performed in which the minimum value of the amplitude is set to 0 and the maximum value of the amplitude is set to 1. The acquisition unit 11 acquires, for example, standardized data as evaluation data. In this case, as evaluation data, data corresponding to the acceleration pulse wave of the user can be obtained.

In addition to sequentially performing each of the above-mentioned processes, the acquisition unit 11 does not have to perform the differential process, for example, as shown in FIG. 3 (c). In this case, as evaluation data, data corresponding to the velocity pulse wave of the user is obtained.

Further, the acquisition unit 11 may perform only a part of each of the above-mentioned processes, for example. In this case, the acquisition unit 11 may acquire any of pulse wave data, differential data, divided data, trimmed divided data, and divided data in which values corresponding to the time axis are standardized as evaluation data. , Can be set arbitrarily according to the application.

<Calculation unit 12>
The calculation unit 12 refers to the database and calculates the user's blood glucose level with respect to the evaluation data. The calculation unit 12 refers to, for example, the classification information stored in the database, and calculates the blood glucose level with respect to the evaluation data. The calculation unit 12 generates a plurality of blood glucose levels for different evaluation data.

The blood glucose level calculated by the calculation unit 12 is calculated as the same type of data as the reference data. The blood glucose level is calculated as the same or similar data as the reference data with reference to the classification information. In the biological information calculation system 100, for example, a plurality of evaluation data are acquired along an arbitrary time series, and a plurality of blood glucose levels for each evaluation data are calculated. In addition, the biometric information calculation system 100 may acquire a plurality of evaluation data at arbitrary timings such as before and after a meal or when the amount of exercise changes, and may calculate a plurality of blood glucose levels for each evaluation data.

<Evaluation unit 13>
The evaluation unit 13 generates an evaluation result including blood glucose spike information indicating a change in the user's blood glucose level based on a plurality of blood glucose levels calculated from different evaluation data. The evaluation unit 13 generates an evaluation result in which the blood glucose spike information is converted into a format that can be understood by the user by using, for example, a display format stored in advance in the storage unit 104 or the like.

The evaluation unit 13 may calculate, for example, the difference between the minimum value and the maximum value among a plurality of blood glucose levels as blood glucose spike information. In this case, the amount of change in blood glucose level can be used as an evaluation target. This makes it possible to easily classify, for example, the characteristics of the diabetic reserve army and the characteristics of diabetic patients.

The evaluation unit 13 calculates, for example, a value obtained by dividing the difference between two blood glucose levels by the difference in measurement time as blood glucose spike information, and generates an evaluation result including the blood glucose spike information. In this case, it is possible to easily grasp the change in the blood glucose level that differs for each user. For example, the evaluation unit 13 refers to a reference value stored in advance in the storage unit 104 or the like, and when the blood glucose spike information is smaller than the reference value, generates an evaluation result indicating that the patient is in a healthy state, and the blood glucose spike information is the reference. If it is greater than or equal to the value, an evaluation result indicating that the patient may have diabetes may be generated.

The evaluation unit 13 may generate an evaluation result from a plurality of blood glucose levels by referring to, for example, an evaluation database. The evaluation database is stored in, for example, the storage unit 104.

The evaluation database may store evaluation classification information for generating evaluation results for a plurality of blood glucose levels, as in the above-mentioned database, for example. In addition to storing one or more evaluation classification information, the evaluation database may store, for example, a plurality of evaluation learning data used for generating the evaluation classification information.

The evaluation classification information is, for example, a function showing the correlation between a plurality of past blood glucose levels (evaluation input data) acquired in advance and the evaluation reference data associated with the evaluation input data. The evaluation reference data shows the tendency of the change in the user's blood glucose level, for example, the blood glucose spike information generated in the past. The evaluation classification information is generated by using a plurality of evaluation training data with the evaluation input data and the evaluation reference data as a pair of evaluation training data.

The evaluation classification information includes, for example, an evaluation input data as an explanatory variable, an evaluation reference data as an objective variable, analysis by the regression analysis described above, and a calibration model generated based on the analysis result. For the evaluation classification information, for example, the calibration model (evaluation calibration model) can be updated periodically, and a plurality of evaluation calibration models generated for each attribute information such as the user's gender, age, and exercise content can be used. It may be included. The evaluation classification information may include a trained model (evaluation trained model) generated by machine learning using, for example, a plurality of evaluation learning data, as in the above-mentioned classification information.

The evaluation unit 13 calculates blood glucose spike information from, for example, time-series changes in a plurality of blood glucose levels, and generates an evaluation result. At this time, the time-series section and the number of blood glucose levels can be arbitrarily set. Therefore, it is possible to generate an evaluation result in consideration of not only the intensity of blood glucose spikes but also the characteristics of the shape.

The evaluation unit 13 may calculate, for example, data in which a plurality of blood glucose levels are associated with the acquisition time of the evaluation data as blood glucose spike information. In this case, as the evaluation result, information indicating the trend of the blood glucose level can be included.

<Output unit 14>
The output unit 14 outputs the evaluation result. In addition to outputting the evaluation result to the display unit 109, the output unit 14 may output the evaluation result to, for example, a sensor 5.

<Memory unit 15>
The storage unit 15 retrieves various data such as a database stored in the storage unit 104 as needed. The storage unit 15 stores various data acquired or generated by the configurations 11 to 14 and 16 in the storage unit 104 as needed.

<Learning Department 16>
The learning unit 16 generates classification information using, for example, a plurality of learning data. The learning unit 16 may acquire new learning data, for example, and update the existing classification information.

The learning unit 16 generates evaluation classification information using, for example, a plurality of evaluation learning data. The learning unit 16 may acquire, for example, new evaluation learning data and update the existing evaluation classification information.

When the classification information and the evaluation classification information are used in the biometric information calculation system 100, the classification information may be updated according to the type of evaluation data, and the evaluation classification information may not be updated. In this case, since it is not necessary to newly prepare learning data for evaluation, it is possible to realize cost reduction and a significant reduction in update time.

<Communication network 3>
The communication network 3 is a known Internet network or the like in which the biometric information arithmetic unit 1, the server 4, and the sensor 5 are connected via a communication line. When the biometric information calculation system 100 is operated in a certain narrow area, the communication network 3 may be configured by a LAN (Local Area Network) or the like. Further, the communication network 3 may be composed of a so-called optical fiber communication network. Further, the communication network 3 is not limited to the wired communication network, but may be realized by a wireless communication network, and can be arbitrarily set according to the application.

<Server 4>
The server 4 stores information sent via the communication network 3. The server 4 transmits the information accumulated via the communication network 3 to the biometric information arithmetic unit 1 based on the request from the biometric information arithmetic unit 1.

The server 4 may be connected to, for example, a plurality of biometric information arithmetic units 1, acquire various information such as evaluation results from each biometric information arithmetic unit 1, and store them collectively. The server 4 may have at least some of the functions of the biometric information arithmetic unit 1 described above. Further, the server 4 may store a database or the like stored in the biometric information arithmetic unit 1 described above.

<Sensor 5>
The sensor 5 generates sensor data. The sensor 5 includes a detection unit 6, for example, as shown in FIG. 5A. The sensor 5 is mounted at a position where the user's pulse wave can be detected via the detection unit 6, and is fixed to, for example, a wristband 55.

As the detection unit 6, a known detection device capable of detecting the pulse wave of the user is used. The detector 6 includes, for example, a strain sensor such as a fiber bragg grating (FBG) sensor, a gyro sensor, one or more electrodes for pulse wave signal measurement, a photoelectric volume pulse wave (PPG) sensor, a pressure sensor, and an optical detection module. At least one of the above is used. A plurality of detection units 6 may be arranged, for example.

The sensor 5 may be embedded in clothing. Further, the user who wears the sensor 5 may target not only humans but also pets such as dogs and cats, and may target livestock such as cows and pigs, and aquaculture of fish and the like.

As shown in FIG. 5B, for example, the sensor 5 includes an acquisition unit 50, a communication I / F 51, a memory 52, and a command unit 53, and each configuration is connected by an internal bus 54.

The acquisition unit 50 measures the pulse wave of the user via the detection unit 6 and generates sensor data. The acquisition unit 50 transmits, for example, the generated sensor data to the communication I / F 51 or the memory 52.

The communication I / F 51 transmits various data such as sensor data to the biometric information calculation device 1 and the server 4 via the communication network 3. Further, the communication I / F 51 is equipped with a line control circuit for connecting to the communication network 3, a signal conversion circuit for performing data communication with the biometric information arithmetic unit 1 and the server 4, and the like. The communication I / F 51 performs conversion processing on various instructions from the internal bus 54 and sends them to the communication network 3 side, and when data from the communication network 3 is received, the communication I / F 51 performs a predetermined conversion processing. Is applied and transmitted to the internal bus 54.

The memory 52 stores various data such as sensor data transmitted from the acquisition unit 50. The memory 52 transmits various data such as stored sensor data to the communication I / F 51 by receiving a command from another terminal device connected via the communication network 3, for example.

The command unit 53 includes an operation button, a keyboard, and the like for acquiring sensor data, and includes, for example, a processor such as a CPU. When the command unit 53 receives the command for acquiring the sensor data, the command unit 53 notifies the acquisition unit 50 of this. Upon receiving this notification, the acquisition unit 50 acquires the sensor data. The command unit 53 may perform a process for acquiring evaluation data from the sensor data, for example, as shown in FIGS. 3 (b) and 3 (c).

Here, a case where an FBG sensor is used will be described as an example of acquiring sensor data.

The FBG sensor has a diffraction grating structure formed in one optical fiber at predetermined intervals. The FBG sensor is characterized in that, for example, the length of the sensor portion is 10 mm, the wavelength resolution is ± 0.1 pm, the wavelength range is 1550 ± 0.5 nm, the fiber diameter is 145 μm, and the core diameter is 10.5 μm. Using the FBG sensor as the detection unit 6 described above, measurement can be performed in a state where the FBG sensor is in contact with the user's skin.

For example, as a light source used for an optical fiber, an ASE (Amplified Spontaneous Emission) light source having a wavelength range of 1525-1570 nm is used. The light emitted from the light source is incident on the FBG sensor via the circulator. The reflected light from the FBG sensor is guided to the Mach-Zehnder interferometer via the circulator, and the output light from the Mach-Zehnder interferometer is detected by the photodetector. The Mach-Zehnder interferometer is for splitting into two optical paths having different optical paths by a beam splitter and superimposing them on one another by a beam splitter to generate interferometric light. In order to make an optical path difference, for example, the length of one optical fiber may be increased. Since coherent light produces interference fringes according to the optical path difference, it is possible to detect a change in distortion generated in the FBG sensor, that is, a pulse wave by measuring the pattern of the interference fringes. The acquisition unit 50 generates sensor data based on the detected pulse wave. As a result, sensor data is acquired.

The optical fiber sensor system that detects the distortion amount of the FBG sensor and detects the waveform of the pulse wave includes a wide band ASE light source, a circulator, a Mach zender interferometer, and a beam splitter in addition to the light source incident on the FBG sensor. It includes an optical system such as, a light receiving sensor included in a photodetector, and an analysis method for analyzing a wavelength shift amount. The optical fiber sensor system can be used by selecting a light source or band light according to the characteristics of the FBG sensor to be used, and various analysis methods such as a detection method can be adopted.

(First Embodiment: Operation of biometric information calculation system 100)
Next, an example of the operation of the biometric information calculation system 100 in this embodiment will be described. FIG. 6 is a flowchart showing an example of the operation of the biometric information calculation system 100 in the present embodiment.

The biometric information calculation system 100 is executed, for example, via a biometric information calculation program installed in the biometric information calculation device 1. That is, the user operates the biometric information calculation device 1 or the sensor 5, and through the biometric information calculation program installed in the biometric information calculation device 1, the user obtains an evaluation result indicating a change in the user's blood glucose level from the sensor data. Can be obtained.

The operation of the biological information calculation system 100 includes an acquisition step S110, a calculation step S120, and an evaluation step S130, and may include, for example, an output step S140.

<Acquisition step S110>
The acquisition step S110 acquires evaluation data based on the user's pulse wave. For example, the acquisition unit 50 of the sensor 5 measures the pulse wave of the user via the detection unit 6 and generates sensor data. The acquisition unit 50 transmits the sensor data to the biometric information calculation device 1 via the communication I / F 51 and the communication network 3. The acquisition unit 11 of the biological information calculation device 1 receives the sensor data from the sensor 5.

The acquisition unit 11 executes the process shown in FIG. 3B, for example, on the sensor data and acquires the evaluation data. The acquisition unit 11 stores the acquired evaluation data in the storage unit 104, for example, via the storage unit 15. Conditions such as the frequency with which the acquisition unit 11 acquires sensor data from the sensor 5 can be arbitrarily set according to the application. For example, the acquisition unit 11 acquires evaluation data at a preset cycle. In this case, since the arithmetic processing when generating the evaluation result can be simplified, the processing speed can be improved.

<Calculation step S120>
Next, the calculation step S120 refers to the database and calculates the user's blood glucose level with respect to the evaluation data. For example, the calculation unit 12 refers to the classification information and calculates the blood glucose level with respect to the evaluation data. The calculation unit 12 stores the calculated blood glucose level in the storage unit 104, for example, via the storage unit 15. In addition to showing a specific value as the blood glucose level, for example, an error range (for example, "○○ ± 5 mg / dl") may be calculated.

<Evaluation step S130>
Next, the evaluation step S130 generates an evaluation result including blood glucose spike information based on a plurality of blood glucose levels generated from different evaluation data. For example, the evaluation unit 13 acquires a plurality of blood glucose levels generated by the calculation unit 12. The evaluation unit 13 may calculate blood glucose spike information from a plurality of blood glucose levels by using a preset function or the like, or may generate an evaluation result by referring to, for example, the above-mentioned evaluation database.

<Output step S140>
Next, for example, the output step S140 may output the evaluation result. For example, the output unit 14 outputs the evaluation result to the display unit 109.

As a result, the operation of the biometric information calculation system 100 is completed. The frequency and order of performing each step can be arbitrarily set according to the application.

According to the present embodiment, the calculation unit 12 calculates the blood glucose level of the user with respect to the evaluation data. The evaluation unit 13 generates an evaluation result including blood glucose spike information indicating a change in the user's blood glucose level based on a plurality of blood glucose levels calculated from different evaluation data. Therefore, it is possible to obtain an evaluation result for a change in blood glucose level regardless of individual differences of users. This makes it possible to realize a quantitative evaluation of changes in blood glucose level.

Further, according to the present embodiment, the calculation unit 12 refers to the database and calculates the blood glucose level of the user with respect to the evaluation data. In addition, the database stores classification information generated using a plurality of learning data. Therefore, when calculating the blood glucose level, it is possible to calculate the quantitative blood glucose level based on the data that has been proven in the past. This makes it possible to improve the accuracy when calculating the blood glucose level.

Further, according to the present embodiment, the evaluation unit 13 calculates blood glucose spike information from time-series changes in a plurality of blood glucose levels and generates an evaluation result. Therefore, it is possible to generate an evaluation result in consideration of not only the intensity of blood glucose spikes but also the characteristics of the shape. This makes it possible to improve the accuracy of evaluation regarding changes in blood glucose level.

(Second Embodiment: Biological Information Calculation System 100)
Next, an example of the biometric information calculation system 100 according to the second embodiment will be described. The difference between the above-described embodiment and the second embodiment is that additional information is used. The description of the same contents as those of the above-described embodiment will be omitted.

In the biometric information calculation system 100 of the present embodiment, for example, the comprehensive evaluation step S150 is carried out after the above-mentioned evaluation step S130, and the output step S140 is carried out after the comprehensive evaluation step S150.

The comprehensive evaluation step S150 acquires additional information, for example, as shown in FIG. 7, and generates a comprehensive evaluation result that evaluates the health condition of the user based on the evaluation result and the additional information. The comprehensive evaluation step S150 can be executed by, for example, the comprehensive evaluation unit included in the evaluation unit 13.

Additional information indicates characteristics related to the user's biological information, such as the user's pulse rate, respiratory rate, blood pressure, lactic acid level, blood carbon dioxide characteristics, oxygen saturation, blood vessel age, stress level, degree of diabetes, etc. In addition, at least one of the biometric information that can be calculated based on the pulse wave is included. The additional information can be used, for example, when estimating the exercise state and health state of the user. The additional information includes attribute information such as the user's gender and age as a feature related to the user's biometric information, as well as exercise that may affect the user's biometric information such as the user's exercise content and competition event. May include information about.

The "characteristics of carbon dioxide in blood" indicates the degree of carbon dioxide contained in blood. As a feature of the blood carbon dioxide, for example, in addition to the value of the blood carbon dioxide partial pressure (PaCO ₂₎ is used, and the dissolved concentration in blood carbon dioxide, bicarbonate, bicarbonate contained in the blood _- the (HCO ³⁾ The concentration may be used, and a value considering the pH of blood may be used depending on the situation.

The additional information is measured using, for example, a known measuring device, and the data format is arbitrary. For example, when measuring the characteristics of blood carbon dioxide concentration, a device such as a percutaneous blood gas monitor TCM5 (manufactured by Radiometer Basel) is used as the measuring device. For example, when measuring the amount of lactate in blood, a known device such as Lactate Pro 2 (manufactured by ARKRAY, Inc.) is used as the measuring device. For example, when measuring oxygen saturation, a known device such as PULSOX-Neo (manufactured by Konica Minolta Co., Ltd.) is used as the measuring device. Further, the timing of acquiring the additional information may be the same as the timing of measuring the pulse wave, or may be any timing depending on the application. The additional information may be input by the user via, for example, the input unit 108, and the method of acquiring the additional information is arbitrary.

The comprehensive evaluation result shows the result of evaluating the health condition of the user. As a comprehensive evaluation result, in addition to "healthy" and "unhealthy", a character string indicating the degree of athletic ability related to the health condition of each user such as "high athletic ability" and "low athletic ability" is used. Also, for example, a difference from an arbitrary reference value or a numerical value such as a deviation value may be used. The comprehensive evaluation result may include, for example, at least one of the evaluation result and additional information.

The comprehensive evaluation result may show a known threshold such as an anaerobic work threshold that differs for each user, or may show a change over time in parameters that affect athletic performance such as the degree of anaerobic metabolism. .. The concentration of, _- the parameters that affect the athletic performance, oxygen uptake, the value of blood carbon dioxide partial pressure (PaCO _2), dissolved gas concentration in the blood carbon dioxide, bicarbonate, bicarbonate contained in the blood (HCO ³⁾ Values indicating characteristics relating to blood composition such as blood pH and the like can be mentioned. By including such parameters in the additional information, it is possible to generate the comprehensive evaluation result with high accuracy.

In particular, since the blood glucose level may depend on the exercise state, the accuracy of the evaluation can be improved by evaluating using the above-mentioned additional information.

In the comprehensive evaluation step S150, for example, the comprehensive evaluation unit refers to a preset threshold value and generates a result of comparing the evaluation result and additional information with the threshold value as the comprehensive evaluation result. For example, the comprehensive evaluation unit generates a comprehensive evaluation result indicating that the athletic ability is high when the evaluation result and the additional information are lower than the threshold value, and when the evaluation result and the additional information are higher than the threshold value, the athletic ability is low. Generate a comprehensive evaluation result showing.

The comprehensive evaluation unit generates, for example, a value obtained by correcting the evaluation result based on the content of the additional information as the comprehensive evaluation result by using a preset function. For example, the blood glucose spike information included in the evaluation result depends on the exercise state of the user at the time of evaluation, and shows a tendency that the peak intensity of the blood glucose spike decreases in inverse proportion to the amount of exercise, for example. Therefore, by correcting the value of the blood glucose spike information based on the content of the additional information, the factor for the change in the blood glucose level can be reduced, and the health condition of the user can be evaluated with high accuracy.

The comprehensive evaluation unit refers to, for example, a user-recognizable data format stored in the storage unit 104 or the like in advance, and generates a comprehensive evaluation result.

The comprehensive evaluation unit may refer to, for example, a database for post-processing and generate a comprehensive evaluation result suitable for the evaluation result and additional information. The post-processing database is stored in, for example, the storage unit 104.

The post-processing database may store post-processing classification information for generating an evaluation result and a comprehensive evaluation result for additional information, as in the database described above, for example. In addition to storing one or more post-processing classification information, the post-processing database may store, for example, a plurality of post-processing learning data used for generating the post-processing classification information.

The post-processing classification information is, for example, a function showing the correlation between the past evaluation results and additional information (post-processing input data) acquired in advance and the post-processing reference data associated with the post-processing input data. .. The post-processing reference data shows the evaluation result of the user's athletic ability. The post-processing classification information is generated by using a plurality of post-processing learning data with the post-processing input data and the post-processing reference data as a pair of post-processing learning data.

The post-processing classification information shows, for example, a calibration model generated based on the analysis results obtained by analyzing the post-processing input data as an explanatory variable and the post-processing reference data as an objective variable by the regression analysis described above. .. The post-processing classification information can be, for example, periodically updated the calibration model (post-processing calibration model), or may be generated for each additional information, for example. Note that the post-processing classification information may include a trained model (post-processing trained model) generated by machine learning using, for example, a plurality of post-processing learning data, similarly to the above-mentioned classification information. ..

According to the present embodiment, in addition to the effects of the above-described embodiment, the comprehensive evaluation unit generates a comprehensive evaluation result that evaluates the health condition of the user based on the evaluation result and additional information. Therefore, in addition to the evaluation result, it is possible to realize a comprehensive evaluation considering the characteristics of the user's biological information. This makes it possible to evaluate the health condition based on the change in the blood glucose level of the user.

Further, according to the present embodiment, the additional information indicates at least one of pulse rate, respiratory rate, blood pressure, characteristics of blood carbon dioxide, lactate level, and oxygen saturation. Therefore, it is possible to perform an evaluation based on a plurality of biological information. This makes it possible to improve the evaluation accuracy.

(Second Embodiment: Modification Example of Biological Information Calculation System 100)
Next, a modified example of the biometric information calculation system 100 in the second embodiment will be described. The difference between one example of the above-described embodiment and the modified example is that additional information is used when calculating the blood glucose level. The description of the same contents as those of the above-described embodiment will be omitted.

In this modification, for example, as shown in FIG. 8, the calculation step S120 includes acquiring additional information and calculating the blood glucose level based on the evaluation data and the additional information.

The additional information is the same as the above-mentioned contents, for example, the user inputs the additional information via the input unit 108 or the like, and the calculation unit 12 or the like acquires the additional information. The calculation unit 12 may determine the calculation method for the evaluation data according to, for example, the content of the additional information. In this case, a function or the like that differs depending on the type of additional information is stored in the storage unit 104 or the evaluation database. The calculation unit 12 may calculate the blood glucose level based on, for example, information that combines evaluation data and additional information.

According to this modification, the calculation unit 12 refers to the database and calculates the blood glucose level based on the evaluation data and the additional information. Therefore, an effective parameter can be used when calculating the blood glucose level of the user. This makes it possible to further improve the accuracy when calculating the blood glucose level.

(Third Embodiment: biometric information calculation system 100)
Next, an example of the biometric information calculation system 100 according to the third embodiment will be described. The difference between the above-described embodiment and the third embodiment is that additional data for generating additional information is acquired. The description of the same contents as those of the above-described embodiment will be omitted.

In the biometric information calculation system 100 of the present embodiment, the acquisition step S110 includes acquiring additional data. Further, in the biometric information calculation system 100 of the present embodiment, the calculation step S120 includes generating additional information based on the additional data.

As shown in FIG. 9, for example, the biological information arithmetic unit 1 in the present embodiment performs two types of processing on one sensor data generated based on a pulse wave. As a result, for example, the acquisition unit 11 acquires the evaluation data and additional data showing features different from the evaluation data based on the same pulse wave. In addition, a plurality of additional data may be acquired.

For example, the calculation unit 12 generates additional information based on the additional data. In the present embodiment, the additional information includes biometric information that can be calculated from the sensor data among the above-mentioned additional information. Depending on the type of additional information generated, for example, the content of preprocessing used when acquiring additional data may be changed.

The calculation unit 12 may generate additional information from the additional data by referring to the database, for example. For example, additional classification information for generating additional information for additional data may be stored in the database. In addition to storing one or more additional classification information, the database may store, for example, a plurality of additional learning data used for generating the additional classification information.

The additional classification information is, for example, a function showing the correlation between the past additional data (additional input data) acquired in advance and the additional reference data associated with the additional input data. The additional reference data includes the additional information described above. The additional classification information is generated by using a plurality of additional learning data with the additional input data and the additional reference data as a pair of additional learning data.

The additional classification information shows, for example, a calibration model generated based on the analysis result obtained by analyzing the additional input data as an explanatory variable and the additional reference data as an objective variable by the regression analysis or the like described above. The additional classification information can, for example, periodically update the calibration model (additional calibration model), and may include a plurality of additional calibration models generated for each attribute information such as the user's gender, age, and exercise content. .. Note that the additional classification information may include a trained model (additional learning model) generated by machine learning using, for example, a plurality of additional learning data, similarly to the above-mentioned classification information.

For example, as shown in FIGS. 10A and 10B, the content of the preprocessing performed in the acquisition step S110 and the content of the additional classification information referred to in the calculation step S120 may be different. Hereinafter, an example of calculating the pulse rate and the respiratory rate as additional information will be described.

<Calculation of pulse rate>
For example, when calculating the pulse rate, as shown in FIG. 10A, the acquisition unit 11 performs the above-mentioned filter processing on the sensor data and extracts the pulse wave data.

Then, the acquisition unit 11 performs a peak position calculation process on the pulse wave data. In the peak position calculation process, a plurality of peaks (maximum amplitude values) included in the pulse wave data are detected, and the sampling order (corresponding to the time from the start of measurement) is specified. As a result, the acquisition unit 11 acquires the peak position data included in the pulse wave data.

After that, the acquisition unit 11 performs a peak interval average calculation process on the peak position data. In the peak interval average calculation process, the interval between peaks included in the peak position data (difference in the order in which adjacent peaks are sampled) is calculated, and for example, the average value of the peak intervals is calculated. After that, the acquisition unit 11 divides the peak interval or the average value of the peak intervals by the sampling rate of the sensor data, and acquires data indicating the peak interval corresponding to the number of seconds as additional data.

After that, the calculation unit 12 refers to the database and calculates the pulse rate for the additional data. At this time, the calculation unit 12 refers to the pulse rate classification information among the additional classification information stored in the database. The pulse rate classification information shows, for example, a function of dividing 60 [seconds] by the peak interval. Therefore, the calculation unit 12 can calculate, for example, the pulse rate (= 71 [bpm]) for the additional data (peak interval = 0.85 [seconds]). As a result, the calculation unit 12 can generate additional information including the pulse rate.

<Calculation of respiratory rate>
For example, when calculating the respiratory rate, as shown in FIG. 10B, the acquisition unit 11 performs the above-mentioned filter processing on the sensor data and extracts the pulse wave data.

After that, the acquisition unit 11 performs a Fourier transform process on the pulse wave data. In the Fourier transform process, for example, pulse wave data indicating sampling time vs. amplitude is converted into frequency data indicating frequency vs. intensity. As a result, the acquisition unit 11 acquires frequency data for the pulse wave data.

After that, the acquisition unit 11 performs the maximum frequency detection process on the frequency data. In the maximum frequency detection process, the frequency having the maximum intensity between 0.15 and 0.35 Hz is specified in the frequency data. As a result, the acquisition unit 11 acquires the value of the specified frequency as additional data.

After that, the calculation unit 12 refers to the database and calculates the respiratory rate for the additional data. At this time, the calculation unit 12 refers to the respiratory rate classification information among the additional classification information stored in the database. The respiratory rate classification information indicates, for example, a function of multiplying the specified frequency by 60 [seconds]. Therefore, the calculation unit 12 can calculate, for example, the respiratory rate (= 13.5 [bpm]) for the additional data (specified frequency = 0.225 Hz). As a result, the calculation unit 12 can generate additional information including, for example, the respiratory rate.

As described above, in the biometric information calculation device 1, the preprocessing for the sensor data can be set according to the content of the data included in the additional information, and the content of the database to be referred to can be arbitrarily set.

In the biometric information calculation system 100 of the present embodiment, for example, as shown in FIG. 11, the output unit 14 may output the generated additional information. In this case, the additional information generated by referring to the information different from the evaluation result can be used, and the user or the like can make a multifaceted judgment. This makes it possible to easily realize an appropriate evaluation according to the user's request.

According to the present embodiment, in addition to the effects of the above-described embodiment, the acquisition unit 11 acquires additional data showing features different from the evaluation data based on the pulse wave. In addition, the calculation unit 12 generates additional information based on the additional data. That is, the evaluation result and additional information are generated based on one pulse wave. Therefore, by using a plurality of types of information based on the same parameter, it is possible to realize comprehensive calculation and evaluation from various viewpoints.

(Fourth Embodiment: Biometric information calculation system 100)
Next, an example of the biometric information calculation system 100 according to the fourth embodiment will be described. The difference between the above-described embodiment and the fourth embodiment is that the above-mentioned additional information is acquired in the evaluation step S130. The description of the same contents as those of the above-described embodiment will be omitted.

In the biometric information calculation system 100 of the present embodiment, for example, as shown in FIG. 12, the evaluation step S130 includes acquiring additional information and generating an evaluation result based on a plurality of blood glucose levels and the additional information.

The additional information is the same as the above-mentioned contents, for example, the user inputs the additional information via the input unit 108 or the like, and the evaluation unit 13 or the like acquires the additional information. For example, the evaluation unit 13 may acquire the additional information generated by the calculation unit 12 based on the additional data acquired by the acquisition unit 11.

The evaluation unit 13 may determine a calculation method for a plurality of blood glucose levels according to, for example, the content of additional information. In this case, a function or the like that differs depending on the type of additional information is stored in the storage unit 104 or the database. The evaluation unit 13 may generate an evaluation result based on, for example, information that combines a plurality of blood glucose levels and additional information.

According to the present embodiment, in addition to the effects of the above-described embodiment, the evaluation unit 13 includes acquiring additional information and generating an evaluation result based on a plurality of blood glucose levels and the additional information. Therefore, in addition to a plurality of blood glucose levels, it is possible to generate multifaceted evaluation results in consideration of the characteristics of the user.

(Fifth Embodiment: Biometric information calculation system 100)
Next, an example of the biometric information calculation system 100 according to the fifth embodiment will be described. The difference between the above-described embodiment and the fifth embodiment is that the attribute-based classification information suitable for the evaluation data is selected from the plurality of attribute-based classification information included in the classification information. The description of the same contents as those of the above-described embodiment will be omitted.

In the biometric information calculation device 1 of the present embodiment, for example, as shown in FIG. 13, the calculation step S120 includes the selection step S121 and the attribute-specific calculation step S122.

The selection step S121 refers to the preliminary evaluation data and selects specific attribute-based classification information (for example, first classification information) from the plurality of attribute-based classification information. The selection step S121 can be executed, for example, by the selection unit included in the calculation unit 12.

The preliminary evaluation data shows characteristics different from the evaluation data, for example, the same characteristics as the above-mentioned additional data. The preliminary evaluation data may be used for generating additional information, for example, like the above-mentioned additional data.

The attribute-based calculation step S122 refers to the selected first classification information and calculates the blood glucose level with respect to the evaluation data. The attribute-based calculation step S122 can be executed, for example, by the attribute-based calculation unit included in the calculation unit 12.

The plurality of attribute-based classification information is calculated using different learning data. For example, when data corresponding to the acceleration pulse wave of the subject is used as the input data of the learning data, input data is prepared for each of the seven types (A to G) as shown in FIG. 14, and seven types of attributes are prepared. Generate classification information.

When such a plurality of attribute-based classification information is stored in the database, for example, the acquisition unit 11 acquires the evaluation data corresponding to the acceleration pulse wave of the user and the preliminary evaluation data. Then, the calculation unit 12 refers to the preliminary evaluation data and selects the first classification information. After that, the calculation unit 12 refers to the first classification information and calculates the blood glucose level with respect to the evaluation data. Therefore, it is possible to select the most suitable classification information for the user from each attribute classification information.

For example, when data corresponding to the velocity pulse wave of the subject is used as the input data of the learning data, the input data is prepared for each of the two types (group 1 and group 2) as shown in FIG. 15, for example. Two types of attribute classification information may be generated.

Here, while the data corresponding to the acceleration pulse wave shown in FIG. 14 can be easily classified in detail based on the characteristics, there is a concern that the accuracy may decrease due to erroneous detection of peaks when calculating the characteristics related to blood composition. Can be mentioned. Further, the data corresponding to the velocity pulse wave shown in FIG. 15 is more difficult to classify in detail based on the characteristics than the data corresponding to the acceleration pulse wave, but the blood glucose level is high because there are few false detections of peaks and the like. It can be calculated accurately.

Based on the above, the plurality of attribute classification information includes data corresponding to the acceleration pulse wave as shown in FIG. 14, as selection data used for selecting specific classification information, and when generating the attribute classification information. Data corresponding to the velocity pulse wave may be used as the training data of.

In this case, in the acquisition step S110, for example, the acquisition unit 11 acquires data corresponding to the velocity pulse wave as evaluation data from the sensor data based on the user's pulse wave. Further, the acquisition unit 11 acquires data corresponding to the acceleration pulse wave as preliminary evaluation data from the sensor data.

Next, as the selection step S121, for example, the calculation unit 12 refers to the preliminary evaluation data, and among the plurality of selection data including the data corresponding to the acceleration pulse wave, the selection data most similar to the preliminary evaluation data (the first). 1) is specified, and the first classification information associated with the first selection data is selected. Then, as the attribute-specific calculation step S122, the calculation unit 12 refers to the first classification information and calculates the blood glucose level with respect to the evaluation data. This makes it possible to further improve the evaluation accuracy.

Here, an example of data used for the above-mentioned selection data and the like will be described.

For example, as shown in FIG. 14, the acceleration pulse wave has inflection points a to e. For example, the maximum peak in the acceleration pulse wave is set to point a, each inflection point is set to point b, c, d, and e in order from point a, point a is set to 1, and the minimum value is point b or d. When standardization is performed with the points set to 0, the acceleration pulse wave can be classified into 7 patterns by using a method of classifying according to the value of each inflection point and the magnitude relation of the difference. First, when the value of the inflection point is b <d, it is classified into pattern A or B. If b <d and c ≧ 0.5, it is classified as A, otherwise it is classified as B. Next, when the value of the inflection point is b≈d, it is classified into pattern C or D. If b≈d and c≈0, it is classified into pattern D, and if not, it is classified into pattern C. Finally, when b> d, it can be classified into any of patterns E, F, and G. If b> d and b <c, it is classified into pattern E, if b≈c, it is classified into pattern F, and if b> c, it is classified into pattern G.

For example, the calculation unit 12 determines which pattern in FIG. 14 the preliminary evaluation data applies to, and specifies the first selection data. For example, if the inflection point b of the input preliminary evaluation data is smaller than the inflection point d and the inflection point c ≧ 0.5, the pattern A is set as the first selection data. As a result, the blood glucose level can be calculated accurately by referring to the classification information suitable for the characteristics of the evaluation data.

According to the present embodiment, in addition to the effects of the above-described embodiment, the calculation unit 12 refers to the preliminary evaluation data and refers to the selection unit that selects the first classification information and the first classification information with respect to the evaluation data. Includes an attribute-based calculation unit that calculates the blood glucose level. Therefore, it is possible to calculate the blood glucose level for the evaluation data after selecting the optimum attribute classification information for the characteristics of the pulse wave. This makes it possible to further improve the evaluation accuracy.

Further, according to the present embodiment, the acquisition unit 11 acquires data corresponding to the velocity pulse wave based on the pulse wave as evaluation data. In addition, the acquisition unit 11 acquires data corresponding to the acceleration pulse wave based on the pulse wave as preliminary evaluation data. Therefore, the attribute classification information can be selected by using the acceleration pulse wave, which makes it easier to classify the characteristics of the pulse wave than the velocity pulse wave. In addition, the blood glucose level can be calculated using a velocity pulse wave, which is easier to calculate the blood glucose level than the acceleration pulse wave. This makes it possible to further improve the evaluation accuracy.

(Fifth Embodiment: Modification example of biometric information calculation system 100)
Next, a modification of the biometric information calculation system 100 according to the fifth embodiment will be described. The difference between the above-described embodiment and the modified example is that the first classification information is selected based on the additional information. The description of the same contents as those of the above-described embodiment will be omitted.

In this modification, for example, as shown in FIG. 16, the calculation step S120 acquires additional information. Further, in the calculation step S120, the first classification information is selected from the classification information based on the additional information, the first classification information is referred to, and the blood glucose level with respect to the evaluation data is calculated.

For example, the calculation unit 12 acquires additional information similar to that of the above-described embodiment. The calculation unit 12 may acquire additional information generated based on the above-mentioned additional data, for example.

For example, the classification information includes a plurality of functions, calibration models, etc. that are sorted in advance according to the characteristics of the additional information. In this case, the calculation unit 12 can select a function or the like (for example, the first classification information) suitable for the feature of the additional information from the classification information. A known technique may be used as a method for selecting the first classification information.

According to this modification, the calculation unit 12 includes referring to the first classification information selected based on the additional information and calculating the blood glucose level with respect to the evaluation data. Therefore, it is possible to calculate the blood glucose level for the evaluation data after selecting the most suitable classification information for the characteristics of the user. This makes it possible to further improve the evaluation accuracy.

Although embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. Such a novel embodiment can be implemented in various other embodiments, and various omissions, replacements, and changes can be made without departing from the gist of the invention. This embodiment and its modifications are included in the scope and gist of the invention, and are also included in the scope of the invention described in the claims and the equivalent scope thereof.

1: Biological information arithmetic unit 3: Communication network 4: Server 5: Sensor 6: Detection unit 10: Housing 11: Acquisition unit 12: Calculation unit 13: Evaluation unit 14: Output unit 15: Storage unit 16: Learning unit 50: Acquisition unit 51: Communication I / F
52: Memory 53: Instruction unit 54: Internal bus 55: Wristband 100: Biometric information calculation system 101: CPU
102: ROM
103: RAM
104: Preservation unit 105: I / F
106: I / F
107: I / F
108: Input unit 109: Display unit 110: Internal bus S110: Acquisition step S120: Calculation step S130: Evaluation step S140: Output step

Claims (11)

A biometric information calculation system that calculates a user's blood glucose level.
An acquisition means for acquiring evaluation data based on the user's pulse wave, and
A pair of input data based on a learning pulse wave acquired in advance and reference data including a blood glucose level associated with the input data is used as learning data, and classification information generated by using a plurality of the learning data is stored. Database and
With reference to the database, a calculation means for calculating the blood glucose level of the user with respect to the evaluation data, and
An evaluation means for generating an evaluation result including blood glucose spike information indicating a change in the blood glucose level of the user based on a plurality of the blood glucose levels calculated from the different evaluation data.
A biometric information calculation system characterized by being equipped with. The biometric information calculation system according to claim 1, wherein the evaluation means calculates the blood glucose spike information from a plurality of time-series changes in the blood glucose level and generates the evaluation result. A claim comprising a comprehensive evaluation means for acquiring additional information indicating characteristics of the user's biological information and generating a comprehensive evaluation result for evaluating the health condition of the user based on the evaluation result and the additional information. Item 1. The biometric information calculation system according to item 1. The calculation means is
Acquire additional information indicating the characteristics of the user's biological information,
The biometric information calculation system according to claim 1, further comprising calculating the blood glucose level based on the evaluation data and the additional information with reference to the database. The acquisition means includes acquiring additional data showing characteristics different from the evaluation data based on the pulse wave.
The biometric information calculation system according to claim 3 or 4, wherein the calculation means includes generating the additional information based on the additional data. The additional information is characterized by indicating at least one of pulse rate, respiratory rate, blood pressure, lactic acid level, characteristics of blood carbon dioxide, oxygen saturation, blood vessel age, stress level, and degree of diabetes. The biometric information calculation system according to any one of items 3 to 5. The acquisition means includes acquiring additional data showing characteristics different from the evaluation data based on the pulse wave.
The biometric information calculation system according to claim 1, wherein the calculation means includes referring to the database and generating additional information indicating the characteristics of the user's biometric information with respect to the additional data. The evaluation means
Acquire additional information indicating the characteristics of the user's biological information,
The biometric information calculation system according to claim 1, further comprising generating the evaluation result based on the plurality of blood glucose levels and the additional information. The acquisition means includes acquiring preliminary evaluation data different from the evaluation data based on the pulse wave.
The classification information includes a plurality of attribute-specific classification information calculated using the different learning data.
The calculation means is
With reference to the preliminary evaluation data, a selection means for selecting the first classification information from the plurality of attribute-specific classification information, and
The biometric information calculation system according to claim 1, further comprising an attribute-based calculation means for calculating the blood glucose level with respect to the evaluation data with reference to the first classification information. The acquisition means
Data corresponding to the velocity pulse wave based on the pulse wave is acquired as the evaluation data, and the data is obtained.
The biometric information calculation system according to claim 9, wherein data corresponding to an acceleration pulse wave based on the pulse wave is acquired as the preliminary evaluation data. The calculation means is
Acquire additional information indicating the characteristics of the user's biological information,
Among the classification information, the first classification information is selected based on the additional information, and the classification information is selected.
The biometric information calculation system according to claim 1, further comprising calculating the blood glucose level with respect to the evaluation data with reference to the first classification information.

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