JP6915810B2 - SorCSペプチド及びそれらの用途 - Google Patents

SorCSペプチド及びそれらの用途 Download PDF

Info

Publication number
JP6915810B2
JP6915810B2 JP2018531443A JP2018531443A JP6915810B2 JP 6915810 B2 JP6915810 B2 JP 6915810B2 JP 2018531443 A JP2018531443 A JP 2018531443A JP 2018531443 A JP2018531443 A JP 2018531443A JP 6915810 B2 JP6915810 B2 JP 6915810B2
Authority
JP
Japan
Prior art keywords
seq
peptide
sorcs2
amino acid
bdnf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2018531443A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019508018A5 (https=
JP2019508018A (ja
Inventor
ヘンセン,モールガード,シモン
ピーデーソン,グラーアップ,シモン
Original Assignee
オーフス ウニベルシテット
オーフス ウニベルシテット
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オーフス ウニベルシテット, オーフス ウニベルシテット filed Critical オーフス ウニベルシテット
Publication of JP2019508018A publication Critical patent/JP2019508018A/ja
Publication of JP2019508018A5 publication Critical patent/JP2019508018A5/ja
Application granted granted Critical
Publication of JP6915810B2 publication Critical patent/JP6915810B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2018531443A 2015-12-18 2016-12-19 SorCSペプチド及びそれらの用途 Expired - Fee Related JP6915810B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201570835 2015-12-18
DKPA201570835 2015-12-18
PCT/DK2016/050445 WO2017101956A1 (en) 2015-12-18 2016-12-19 SorCS PEPTIDES AND USES THEREOF

Publications (3)

Publication Number Publication Date
JP2019508018A JP2019508018A (ja) 2019-03-28
JP2019508018A5 JP2019508018A5 (https=) 2020-01-30
JP6915810B2 true JP6915810B2 (ja) 2021-08-04

Family

ID=59055867

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018531443A Expired - Fee Related JP6915810B2 (ja) 2015-12-18 2016-12-19 SorCSペプチド及びそれらの用途

Country Status (4)

Country Link
US (1) US20190345216A1 (https=)
EP (1) EP3390435A1 (https=)
JP (1) JP6915810B2 (https=)
WO (1) WO2017101956A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230312652A1 (en) 2020-08-06 2023-10-05 Aarhus Universitet Novel peptides and uses thereof
WO2023152229A1 (en) 2022-02-09 2023-08-17 Teitur Trophics Aps Novel peptides
AU2024324156A1 (en) 2023-08-16 2026-02-12 Teitur Trophics Aps Peptides for the treatment of disorders of the inner ear or the mastoic process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1891966B1 (en) * 2002-12-20 2012-02-15 H. Lundbeck A/S Modulation of activity of neurotrophins; screening method
EP2307042B1 (en) * 2008-06-25 2014-03-26 H. Lundbeck A/S Modulation of the trpv : vps10p-domain receptor system for the treatment of pain
EP3165537A1 (en) * 2008-12-19 2017-05-10 H. Lundbeck A/S Modulation of the vps 10-domain receptor family for the treatment of mental and behavioural disorders
US20130336988A1 (en) * 2010-11-17 2013-12-19 New York University Methods for treating early stage or mild neurological disorders

Also Published As

Publication number Publication date
EP3390435A1 (en) 2018-10-24
WO2017101956A1 (en) 2017-06-22
JP2019508018A (ja) 2019-03-28
US20190345216A1 (en) 2019-11-14

Similar Documents

Publication Publication Date Title
Duan et al. Semaphorin 5A inhibits synaptogenesis in early postnatal-and adult-born hippocampal dentate granule cells
Hudry et al. Inhibition of the NFAT pathway alleviates amyloid beta neurotoxicity in a mouse model of Alzheimer's disease
Klugmann et al. AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats
Hadano et al. Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
US8703125B2 (en) Modulation of the Vps10p-domain receptor family for the treatment of mental and behavioural disorders
EP2282728B1 (en) Modulation of the Vps10p-domain receptors.
ES2241654T3 (es) Polipeptido, humanina, que suprime la muerte neuronal.
Langston et al. The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research
JP6664464B2 (ja) 細胞透過性が改善された(iCP)パーキン組換えタンパク質及びその使用
Hui et al. Expression pattern of Nogo‐A, MAG, and NgR in regenerating urodele spinal cord
Borgese et al. Mutant VAPB: culprit or innocent bystander of amyotrophic lateral sclerosis?
Zhang et al. Cholecystokinin signaling can rescue cognition and synaptic plasticity in the APP/PS1 mouse model of Alzheimer’s disease
Dorner-Ciossek et al. Role of PDE9 in cognition
JP6915810B2 (ja) SorCSペプチド及びそれらの用途
Elbaz et al. Reduced synaptic density and deficient locomotor response in neuronal activity‐regulated pentraxin 2a mutant zebrafish
Knorr et al. The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor
AU2003288434B2 (en) Peptides, antibodies thereto, and their use in the treatment of central nervous system damage
JP6606428B2 (ja) 脊髄小脳変性症を予防又は治療するための薬剤
Parsi et al. A novel rat model of Alzheimer’s disease based on lentiviral-mediated expression of mutant APP
Frison et al. The 18 kDa Translocator protein (TSPO): cholesterol trafficking and the biology of a prognostic and therapeutic mitochondrial target
Palata Investigating the role of IRE1 in brain regeneration using a larval zebrafish model
Fallon Pathological implications of the interaction between neurexins and alpha-synuclein in synucleinopathies
Kotova Molecular Mechanisms Underlying Regulation and Function of Neuronal Gap Junction Proteins: Connexin 36 and Connexin 27.5.
Nicolas Understanding Molecular Mechanisms of Striated Muscle Laminopathies Using Cellular and Zebrafish Models
Chan Calcium signalling in TDP-43 models of motor neurone disease and frontotemporal dementia

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181116

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20181220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20181220

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20181226

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20190919

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191210

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210105

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210401

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210608

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210706

R150 Certificate of patent or registration of utility model

Ref document number: 6915810

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees