JP6908264B2 - Ceramide-containing non-aqueous gel composition and cosmetics containing it - Google Patents

Description

The present invention relates to a ceramide-containing non-water gel-like composition and a cosmetic containing the non-water gel-like composition and containing no water.

Ceramide is contained in the intercellular lipids of the stratum corneum of the skin and is said to contribute to the skin barrier function, and is attracting attention as a highly functional moisturizer. However, since ceramide generally has poor solubility in a cosmetic base material regardless of whether it is water-soluble or oil-soluble, it is difficult to contain it in a large amount in cosmetics. Further, even if it can be contained, there is a problem that crystals are precipitated with time, which impairs the usability and appearance of the cosmetic and lowers the commercial value.

Ceramides are divided into racemates that do not have optical activity and optically active substances that have optical activity. All naturally occurring ceramides are optically active substances, and it is said that the optically active substances have a higher moisturizing effect. However, on the other hand, since the optically active substance has a high melting point and strong crystallinity, it is difficult to include it in a large amount in cosmetics (Non-Patent Document 1).

In order to contain ceramide in external preparations for skin such as cosmetics, many attempts have been made to combine various compounds to improve their solubility and suppress crystallization. Among them, the technology related to the composition having a liquid crystal structure imitating the intercellular lipids of the skin has been attracting attention in recent years. By having the liquid crystal structure, a ceramide-containing composition having characteristics such as excellent absorption of ceramide into the skin, excellent effect of suppressing water evaporation, and excellent usability can be obtained.

For example, by dispersing ceramide, fatty alcohol, and polyglycerin fatty acid ester with a polyhydric alcohol-containing aqueous solvent, a dispersion having a liquid crystal structure can be obtained, and this technique is excellent in both usability and stability. It has been reported that an external preparation for skin can be produced (Patent Document 1, Patent Document 2). In addition, emulsified cosmetics containing ceramide, higher fatty acid or higher alcohol, liquid non-polar oil or silicone oil, amphipathic polymer, and water have a liquid crystal structure, are not sticky, are excellent in usability, and evaporate water. It has been reported that the inhibitory effect is high (Patent Document 3). In addition, an emulsified composition containing sphingosine, ceramide, glycerin monofatty acid ester, higher alcohol, and water has been reported (Patent Document 4). By these techniques, the precipitation of crystals is suppressed, and an emulsified composition having excellent stability over time and a high moisturizing effect can be produced.

However, even with these technologies, there is an upper limit to the ceramide content, and there are problems that must be solved industrially, such as insufficient stability over time such as high temperature, low temperature, and freezing and thawing. It was still there, and a solution was desired.

Japanese Unexamined Patent Publication No. 2004-331594 Japanese Unexamined Patent Publication No. 2004-331595 JP-A-2007-63145 JP-A-2007-22997

"Oleoscience" Vol. 4, No. 3, p. 19, 2004, published by Japan Oil Chemists' Society

An object of the present invention is to contain a non-water gel-like composition having excellent stability over time that does not crystallize in oil even if it contains a high amount of ceramide, and the non-water gel-like composition that does not crystallize ceramide over time. It is to provide a water-free cosmetic with excellent stability.

In view of such circumstances, as a result of diligent studies by the present inventor, a non-aqueous gel composition containing an oil agent which is liquid at 25 ° C. excluding the optically active substances ceramide, meadowfoam estride, and meadowfoam estride is crystalline. It was found that the crystals do not precipitate and are excellent in stability over time, and that even in a cosmetic containing the non-water gel-like composition and not containing water, crystals do not precipitate and the stability over time is excellent.

That is, in the present invention, the following components (A) to (C)
(A) Provided is a non-aqueous gel composition containing an oil agent which is liquid at 25 ° C. excluding ceramide (B) meadowfoam estride (C) meadowfoam estride which is an optically active substance.

Further, the present invention is in the form of a non-aqueous gel in which the content of the component (A) is 20.0% by weight or less and the content of the component (B) is 0.2 to 2.0 times that of the component (A). It provides a composition.

The present invention also provides a non-aqueous gel composition in which 50.0% by weight or more of the component (C) is a non-polar oil.

The present invention also provides a non-aqueous gel-like composition characterized in that the non-aqueous gel-like composition has a lamellar liquid crystal structure.

The present invention also provides a cosmetic containing the non-water gel composition and containing no water.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a non-water gel-like composition in which ceramide does not crystallize and is excellent in stability over time, and a water-free cosmetic containing the non-water gel-like composition.

FIG. 1 is a polarizing microscope image of Example 3. FIG. 2 is a polarizing microscope image of Comparative Example 5. FIG. 3 is an X-ray diffraction profile of a small angle region of Example 4 and Comparative Example 1. FIG. 4 is an X-ray diffraction profile of a wide-angle region of Example 4 and Comparative Example 1. FIG. 5 is a polarizing microscope image of Example 27.

Hereinafter, the present invention will be described in detail.
As described above, ceramide includes an optically active substance and a racemic form, but in the present invention, the optically active substance is used. The ceramide used in the present invention is a general term for compounds in which a long-chain fatty acid is amide-bonded to the amino group of sphingosine. Among those used as raw materials for cosmetics, ceramides 1 to 6 are known due to differences in the structure of sphingosine and the structure of long-chain fatty acids. The ceramide which is the component (A) optically active substance of the present invention can be used in any ceramide, and among them, ceramide 2, ceramide 3, and ceramide 6 are preferable. This is because when these ceramides are used, a ceramide-containing non-aqueous gel composition having particularly excellent stability over time can be obtained. In addition, one kind or two or more kinds of these can be used as needed. As ceramide 2, CERAMIDE TIC-001 has been put on the market by Takasago International Corporation, and it can be purchased and used. As ceramide 3, Ceramide III and Ceramide IIIB have been marketed by Evonik, and these can be purchased and used. As ceramide 6, Ceramide VI has been put on the market by Evonik, and it can be purchased and used.

The content of the ceramide which is the component (A) optically active substance is not particularly limited, but is preferably 20.0% by weight or less of the whole non-aqueous gel composition. If it exceeds 20.0% by weight, crystals may precipitate.

The component (B) Meadowfoam Estride of the present invention is a liquid polar oil prepared by dehydrating and condensing a fatty acid derived from Meadowfoam oil and a hydroxy fatty acid and esterifying them. Meadowfoam Estrid is available on the market from Ichimaru Falcos, and you can purchase and use it.

The content of the component (B) meadowfoam estride is not particularly limited, but is preferably 0.2 to 2.0 times the content of the component (A). If it is less than 0.2 times or more than 2.0 times, there may be a problem that ceramide crystals are precipitated in the gel-like composition over time.

As the oil agent liquid at 25 ° C. excluding the component (C) Meadowfoam Estride of the present invention, oil agents such as non-polar oil, polar oil, and silicone oil usually used in cosmetics can be used. Non-polar oils are oils consisting only of carbon and hydrogen, and examples thereof include isododecane, isohexadecane, light liquid isoparaffin, liquid paraffin, heavy liquid isoparaffin, α-olefin oligomer, squalane, polyisobutylene, polybutene and the like. Is not limited to these. Polar oil is an oil agent containing a hydroxyl group, a carboxyl group, an ether bond, and an ester bond in molecules such as higher fatty acids, higher alcohols, fats and oils, ethers, and ester oils, and examples thereof include oleic acid, isostearic acid, linoleic acid, and oleyl. Alcohol, isostearic alcohol, avocado oil, olive oil, persic oil, kukui nut oil, grape seed oil, saflower oil, almond oil, corn oil, pistacio seed oil, sunflower oil, hazelnut oil, macadamia nut oil, meadowfoam oil, rose hips Oil, diisononyl ether, jojoba oil, butyl myristate, butyl stearate, cetyl ethylhexanate, ethyl oleate, hexyldecyl isostearate, isosetyl myristate, isosetyl stearate, ethylhexyl palmitate, isopropyl isostearate, isopropyl myristate, Isostearyl palmitate, isostearyl palmitate, octyldodecyl myristate, ethylhexyl stearate, ethyl linoleate, isopropyl linoleate, octyldodecyl neopentate, butyloctyl salicylate, diglyceryl triisostearate, propylene glycol dicaprate, pentaethylhexanoate tetraethylhexanoate Elyslityl, propylene glycol monocaptrylate, propylene glycol dicaprylate, trimethylolpropane triethylhexanoate, trimethylolpropane triisostearate, glyceryl tri2-ethylhexanoate, glyceryl tri (caprylic acid / capric acid), 2-ethylhexane 2-Butyl-2-ethyl acid-1,3-propanediol, diethyl sebacate, diisopropyl adipate, diisopropyl sebacate, di2-ethylhexyl 2,6-naphthalindicarboxylate, dibutyloctyl sebacate, diisostearyl malate , Triethylhexyl citrate, diglyceryl triisostearate, decaglyceryl pentaoleate, decaglyceryl decaisostearate, decaglyceryl decaoleate, decaglyceryl decamacademia nut oil fatty acid, and the like, but are not limited thereto. Silicone oil is an oil agent having a skeleton in which silicon and oxygen are alternately connected by siloxane bonds. Of the silicone oils, any silicone oil compatible with Meadowfoam Estride can be used in the present invention. Examples include, but are not limited to, dimethyl silicone, methyl phenyl silicone, cyclic dimethyl silicone, alkyl-modified silicone and the like. Moreover, these may use 1 type or 2 or more types as needed.

In the present invention, it is particularly preferable that 50.0% by weight or more of the component (C) is a non-polar oil. If it is less than 50.0% by weight, ceramide crystals may precipitate over time.

After confirming that the component (A), the component (B), and the component (C) are heated and dissolved, the non-aqueous gel composition is formed by cooling to 30 ° C. The non-aqueous gel-like composition has a lamellar liquid crystal structure, ceramide crystals do not precipitate for a long period of time, and the composition is stable over time.

The ceramide-containing non-aqueous gel composition of the present invention contains various components, for example, anionic surfactant, cationic surfactant, nonionic surfactant, solid at 25 ° C. or It may contain paste-like oils, UV absorbers, preservatives, moisturizers, thickeners, coloring agents, sequestrants, antioxidants, beauty ingredients, fragrances, refreshing agents, pH adjusters, etc. as appropriate. can. However, these various components are preferably 0.5% by weight or less in total. If it exceeds 0.5% by weight, ceramide crystals may precipitate over time.

In the present invention, by incorporating the above-mentioned ceramide-containing non-aqueous gel-like composition into a water-free cosmetic, it is possible to provide a cosmetic having excellent stability over time without precipitation of ceramide crystals. On the other hand, when the non-water gel-like composition is contained in a cosmetic containing water, ceramide crystals may be precipitated, which may cause a problem in stability over time.

Since the melting point of the ceramide-containing non-aqueous gel composition of the present invention is around 85 ° C., when preparing a cosmetic containing the non-aqueous gel composition, the temperature of the non-aqueous gel composition is lower than the melting point. For example, it may be charged at 80 ° C. or lower and dispersed using a roll mill, a homomixer, a disper mixer or the like.

It is desirable that the non-water gel composition to be contained in the cosmetic containing the ceramide-containing non-water gel composition of the present invention is 0.1% by weight to 50.0% by weight of the whole cosmetic. If it is less than 0.1% by weight, the purpose of high content may not be achieved, and if it exceeds 50.0% by weight, the desired usability may not be obtained.

The cosmetic containing the ceramide-containing non-aqueous gel composition of the present invention includes various components, for example, anionic surfactants and cationic surfactants, depending on the purpose of use, as long as the effects of the invention are not impaired. Appropriately contains nonionic surfactants, oils, UV absorbers, preservatives, moisturizers, thickeners, coloring agents, metal ion sequestering agents, antioxidants, beauty ingredients, fragrances, refreshing agents, pH adjusters, etc. can do.

The ceramide-containing non-aqueous gel composition of the present invention can be used alone as a balm-like beauty essence or lip balm. In addition, as cosmetics containing a ceramide-containing non-water gel-like composition in which the non-water gel-like composition is dispersed in other components, oil beauty liquid, lip gloss, body oil, hair oil, hair wax, eye gloss, and oiliness Examples include foundations, lipstick overcoats, lip essences, and liquid rouge.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. The contents in the examples are all% by weight.

Examples 1 to 25, Comparative Examples 1 to 11 Ceramide-containing non-aqueous gel composition A non-aqueous gel containing an oil agent that is liquid at 25 ° C. excluding ceramide, meadowfoam estride, and meadowfoam estride. The preparation method and the evaluation method of the state composition will be described in detail. In the formulations shown in Examples 1 to 25 and Comparative Examples 1 to 11 shown below, all the components were heated to 95 ° C., and it was confirmed that the paste-like or solid components in the formulation were completely dissolved. After that, it was cooled to 30 ° C. The state of the obtained composition after being left at 40 ° C. for 1 month, 3 months and 6 months was observed with a polarizing microscope under a cross Nicol, and classified as follows.
<Polarizing microscope image>
◯: Texture is seen, and no crystals are seen.
Δ: Texture can be seen, but crystals can also be seen.
X: No texture is seen and crystals are seen.
-: No texture or crystals can be seen.
It should be noted that the texture is a pattern that is seen when a defect having a rapid non-uniformity in the orientation of the molecule is generated due to the flow, and suggests that it has a liquid crystal structure. Further, FIG. 1 shows the state of the texture seen in Example 3, and FIG. 2 shows the state of the crystal seen in Comparative Example 5. The classification results are shown in the table.

＊１：ＣＥＲＡＭＩＤＥ ＴＩＣ−００１（高砂香料工業製）
＊２：メドウエストリド（一丸ファルコス製）
＊３：ＣＡＲＮＡＴＩＯＮ（ＳＯＮＮＥＢＯＲＮ ＩＭＣ製）

* 1: CERAMIDE TIC-001 (manufactured by Takasago International Corporation)
* 2: Medwest lid (made by Ichimaru Falcos)
* 3: CARANTION (manufactured by SONNEBORN IMC)

The results of changing the content of ceramide 2 while fixing the ratio of ceramide 2 and meadowfoam estride are shown in Examples 1 to 7 of Table 1. In Examples 1 to 6, no crystals were observed even after being left at 40 ° C. for 1 month, 3 months and 6 months, and only the texture was confirmed. In Example 7, no crystals were observed and only the texture was confirmed after being left at 40 ° C. for 1 month and 3 months, but after being left at 40 ° C. for 6 months, crystals were confirmed together with the texture.

＊４：ＥＸＴＲＡ ＯＬＥＩＣ−９０（日油製）
＊５：オレイルアルコール ＶＰ（高級アルコール工業製）
＊６：イソステアリン酸（日産化学工業製）
＊７：ファインオキソコール １８０（日産化学工業製）
＊８：１２−ヒドロキシステアリン酸（伊藤製油製）
＊９：ＮＡＡ−１７３Ｋ（日油製）
＊１０：ステアリルアルコール ＮＸ（高級アルコール工業製）

* 4: EXTRA OLEIC-90 (manufactured by NOF)
* 5: Oleyl alcohol VP (manufactured by higher alcohol industry)
* 6: Isostearic acid (manufactured by Nissan Chemical Industries, Ltd.)
* 7: Fine Oxyacid 180 (manufactured by Nissan Chemical Industries, Ltd.)
* 8: 12-Hydroxystearic acid (manufactured by Itoh Oil Chemicals)
* 9: NAA-173K (manufactured by NOF)
* 10: Stearyl alcohol NX (manufactured by higher alcohol industry)

As a result of the case where Comparative Example 1 in Table 2 does not contain Meadowfoam Estride, Fatty Acids which do not contain Meadowfoam Estride in Comparative Examples 2 to 8 and have a relatively similar chemical structure instead of Meadowfoam Estride. Alternatively, the result when a higher alcohol is contained is shown. In Comparative Examples 1 to 8, after being left at 40 ° C. for 1 month, 3 months and 6 months, no texture was observed in any of the cases, and only crystals were confirmed.

＊１１：パールリーム ＥＸ（日油製）
＊１２：ＮＩＫＫＯＬ シュガースクワラン（日光ケミカルズ製）

* 11: Pearl Dream EX (manufactured by NOF)
* 12: NIKKOL Sugar Squalene (manufactured by Nikko Chemicals)

The results when the content of meadowfoam estride was changed while fixing the content of ceramide 2 in Examples 8 to 14 of Table 3 are shown. In Examples 9 to 13, no crystals were observed even after being left at 40 ° C. for 1 month, 3 months and 6 months, and only the texture was confirmed. In Examples 8 and 14, no crystals were observed after being left at 40 ° C. for 1 month and 3 months, and only the texture was confirmed, but after being left at 40 ° C. for 6 months, crystals were confirmed together with the texture. ..

＊１３：ＮＩＫＫＯＬ シンセラン４ＳＰ（日光ケミカルズ製）
＊１４：ＯＤＭ（高級アルコール工業製）
＊１５：Ｐｌａｎｄｏｏｌ−ＬＧ１（日本精化製）

* 13: NIKKOL Syntheran 4SP (manufactured by Nikko Chemicals)
* 14: ODM (manufactured by higher alcohol industry)
* 15: Plandoll-LG1 (manufactured by Nippon Fine Chemical Co., Ltd.)

Α-olefin oligomers and polar oils, which are non-polar oils, while fixing the contents of ceramide 2, meadowfoam estride and di (octyldodecyl / phytosteryl / behenyl) lauroyl glutamate in Examples 15 to 20 in Table 4. The results when the ratio with octyldodecyl myristate is changed are shown. In Examples 15 to 17, no crystals were observed even after being left at 40 ° C. for 1 month, 3 months and 6 months, and only the texture was confirmed. In Examples 18 to 20, no crystals were observed after being left at 40 ° C. for 1 month and 3 months, and only the texture was confirmed, but after being left at 40 ° C. for 6 months, crystals were confirmed together with the texture. ..

Comparative Examples 9 to 11 in Table 5 show the results when the oil agent which is liquid at 25 ° C. excluding Meadowfoam Estride is not contained. In Comparative Example 9, after being left at 40 ° C. for 1 month, 3 months and 6 months, neither crystals nor textures were confirmed, and the appearance did not become a gel-like composition. In Comparative Examples 10 and 11, only crystals were confirmed after being left for 1 month, 3 months and 6 months.

＊１６：フィトステロール−ＳＫＰ（タマ生化学製）
＊１７：ＮＩＫＫＯＬ レシノール Ｓ−ＰＩＥ（日光ケミカルズ製）
＊１８：メッキンス−Ｂ（上野製薬製）

* 16: Phytosterol-SKP (manufactured by Tama Biochemical)
* 17: NIKKOL Resinol S-PIE (manufactured by Nikko Chemicals)
* 18: Plating-B (manufactured by Ueno Fine Chemicals)

The results of changing the content of phytosterol while fixing the ratios of ceramide 2, meadowfoam estride, hydrogenated lecithin and butylparaben are shown in Examples 21 to 26 of Table 6. In Examples 21 to 24, no crystals were observed and only the texture was confirmed even after being left at 40 ° C. for 1 month, 3 months and 6 months. In Examples 25 and 26, no crystals were observed after being left at 40 ° C. for 1 month and 3 months, and only the texture was confirmed. However, after being left at 40 ° C. for 6 months, crystals were confirmed together with the texture. Was done.

In order to confirm the internal structure of the ceramide-containing non-aqueous gel composition of the present invention, simultaneous small-angle and wide-angle X-ray diffraction measurements were performed at the beamline BL8S3 of the Aichi Synchrotron Optical Center. The X-ray energy was 13.9 KeV, the X-ray wavelength was 0.09 nm, the camera length was 468 mm, and the irradiation time was 300 seconds. RAXIS (manufactured by Rigaku) was used for the camera, and 300 x 300 mm was used for the imaging plate. .. The sample was measured by packing it in an aluminum DSC cell (manufactured by METTLER). The obtained diffraction image was made one-dimensional by the FIT2D (ESRF) program, and the horizontal axis was plotted as the scattering vector S (= q / 2π) and the vertical axis was plotted as the scattering intensity.

FIG. 3 shows an X-ray diffraction profile in a small angle region, and FIG. 4 shows an X-ray diffraction profile in a wide angle region. In Example 4 of FIG. 3, the primary, secondary and tertiary diffraction peaks of the lamellar structure are 0.217 nm ^-1 (4.61 nm), 0.432 nm ^-1 (2.31 nm) and 0.655 nm, respectively. ^{It appears at -1} (1.53 nm), indicating the existence of a lamellar structure with a period of about 4.6 nm. Similarly, in Comparative Example 1 of FIG. 3, the primary, secondary and tertiary diffraction peaks of the lamellar structure are 0.249 nm ^-1 (4.02 nm), 0.502 nm ^-1 (1.99 nm) and 0.502 nm -1 (1.99 nm), respectively. It appears at 0.750 nm ^-1 (1.33 nm), indicating the presence of a lamellar structure with a period of about 4.0 nm. It is presumed that the reason why the surface spacing is wider in Example 4 is that the oil agent is held in the lamellar structure. Further, in Example 4 of FIG. 4, a broad diffraction peak is observed at 2.50 ^{nm -1 (0.40 nm).} This indicates that the packed structure is poorly ordered and has a liquid crystal structure. On the other hand, in Comparative Example 1, two diffraction peaks are observed at ^{2.22 nm -1} (0.45 nm) and 2.66 nm ^{-1 (0.38 nm).} This is clearly different from the packed structure of Example 4 and means that orthorhombic crystals are present. That is, it can be seen that Example 4 has a lamellar liquid crystal structure unlike Comparative Example 1.

Examples of cosmetics containing the gel-like composition and not containing water will be given below. FIG. 5 is a polarizing microscope image of Example 27. Martese cloth appears, suggesting that the gel-like substance having a lamellar liquid crystal structure is dispersed.

Example 27 Lip gloss (ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 2.0
(2) Meadowfoam Estride (* 2) 3.0
(3) Liquid paraffin (* 3) 10.0
(Phase B)
(4) Dextrin palmitate 5.0
(5) Liquid paraffin 10.0
(6) Diisostearyl malate 10.0
(7) Methylphenylpolysiloxane 10.0
(8) Diglyceryl triisostearate Remaining amount (9) Appropriate amount of fragrance (manufacturing method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. Phase A is added to phase B at 30 ° C., and the mixture is uniformly mixed and dispersed on a roll mill.

Example 28 Liquid Rouge (ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 0.5
(2) Meadowfoam Estride (* 2) 0.9
(3) Liquid paraffin (* 3) 8.0
(Phase B)
(4) Inulin stearate 0.5
(5) 12-Hydroxystearic acid 0.5
(6) Microcrystalline wax 5.0
(7) Heavy liquid isoparaffin 30.0
(8) Methylphenylpolysiloxane 5.0
(9) Decamethylcyclopentasiloxane 10.0
(10) Remaining amount of glyceryl tri2-ethylhexanoate (Phase C)
(11) Cyrilization treatment Silicic anhydride 3.0
(12) Red No. 201 0.5
(13) Yellow No. 4 0.3
(14) Mica titanium 1.0
(15) Natural Vitamin E 0.1
(16) Appropriate amount of fragrance (manufacturing method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. The A phase and the C phase are added to the B phase at 30 ° C., and the mixture is uniformly mixed and dispersed by a roll mill.

Example 29 Lip Essence (ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 1.0
(2) Meadowfoam Estride (* 2) 0.5
(3) Squalene (* 12) 10.0
(Phase B)
(4) Dextrin palmitate 12.0
(5) 2-Ethylhexyl paramethoxycinnamate 5.0
(6) Trimethylpentaphenyltrisiloxane 25.0
(7) Polyethylene wax 5.0
(8) Polybutene 5.0
(9) Remaining amount of cetyl 2-ethylhexanoate (10) Diisostearyl malate 30.0
(11) Di-lauroyl-glutamic acid (phytosteryl behenyl octyldodecyl) 5.0
(12) Methylparaben 0.1
(13) Beeswax 0.5
(14) Refined olive oil 0.1
(15) Refined jojoba oil 0.1
(16) Appropriate amount of fragrance (manufacturing method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. Phase A is added to phase B at 30 ° C., and the mixture is uniformly mixed and dispersed on a roll mill.

Example 30 Lipstick overcoat (ingredient name) Weight (%)
(Phase A)
(1) Ceramide 3 (* 19) 0.5
(2) Meadowfoam Estride (* 2) 0.5
(3) Liquid paraffin (* 3) 5.0
(Phase B)
(4) Sucrose polystearate 1.0
(5) Trimethylpentaphenyltrisiloxane 25.0
(6) Methylphenylpolysiloxane 25.0
(7) Dimethylpolysiloxane 3.0
(8) Trimethylsiloxysilicic acid 5.0
(9) Remaining amount of decamethylcyclopentasiloxane (10) Diisostearyl malate 10.0
(C phase)
(11) Cyrilization treatment Silicic anhydride 8.0
(12) Appropriate amount of fragrance * 19: Ceramide III (made by Evonik)
(Production method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. The A phase and the C phase are added to the B phase at 30 ° C., and the mixture is uniformly mixed and dispersed by a roll mill.

Example 31 Paste-like oily foundation (ingredient name) Weight (%)
(Phase A)
(1) Ceramide 6 (* 20) 0.2
(2) Meadowfoam Estride (* 2) 0.1
(3) Hydrogenated polyisobutene (* 11) 3.0
(4) Isostearyl isostearate (* 21) 2.0
(Phase B)
(5) Hydrogenated polyisobutene 40.0
(6) Remaining amount of liquid paraffin (7) Myristic acid dextrin ester 5.0
(C phase)
(8) Talc 5.0
(9) Kaolin 5.0
(10) Titanium oxide 4.0
(11) Bengala 1.0
(12) Iron yellow oxide 4.0
(13) Black iron oxide 0.2
(14) Cyrilization treatment Silicic anhydride 5.0
(15) Diisostearyl malate 10.0
(16) Appropriate amount of fragrance * 20: Ceramide VI (made by Evonik)
* 21: Kurodamol ISIS-LQ- (JP) (manufactured by Croda Japan)
(Production method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. The A phase and the C phase are added to the B phase at 30 ° C., and the mixture is uniformly mixed and dispersed by a roll mill.

Example 32 Oil-based eye gloss
(Ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 0.3
(2) Meadowfoam Estride (* 2) 0.4
(3) Liquid paraffin (* 3) 7.0
(Phase B)
(4) Hydrogenated polyisobutene 30.0
(5) Remaining amount of liquid paraffin (6) Dextrin palmitate 5.0
(7) 2-ethylhexyl paramethoxycinnamate 1.0
(8) Natural Vitamin E 0.01
(C phase)
(9) Red No. 202 0.004
(10) Gunjo 0.016
(11) Titanium oxide 5.0
(12) Cyrilization treatment Silicic anhydride 5.0
(13) Glyceryl triisostearate 20.0
(14) Appropriate amount of fragrance (manufacturing method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. The A phase and the C phase are added to the B phase at 30 ° C., and the mixture is uniformly mixed and dispersed by a roll mill.

Example 33 Paste-like oily hair wax
(Ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 0.2
(2) Meadowfoam Estride (* 2) 0.1
(3) Liquid paraffin (* 3) 2.0
(Phase B)
(4) Bead wax 2.0
(5) Hydrogenated polyisobutene 10.0
(6) Phenyltrimethicone 5.0
(7) Remaining amount of liquid paraffin (8) Macademia nut oil fatty acid cholesteryl 10.0
(9) Pentaerythritol rosinate 2.0
(10) Dextrin palmitate 3.0
(11) Dimethylpolysiloxane 1CS 0.5
(C phase)
(12) Black iron oxide 2.0
(13) Cyrilization treatment Silicic anhydride 2.0
(14) Glyceryl triisostearate 20.0
(15) Appropriate amount of fragrance (manufacturing method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. The A phase and the C phase are added to the B phase at 30 ° C., and the mixture is uniformly mixed and dispersed by a roll mill.

Example 34 Hair oil
(Ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 2.0
(2) Meadowfoam Estride (* 2) 1.0
(3) Liquid paraffin (* 3) 29.8
(4) Cholesterol (* 22) 0.2
(Phase B)
(5) Remaining amount of liquid paraffin (6) Olive oil 2.1
(7) Octyldodecanol 0.8
(8) Oxybenzone-3 0.05
(9) Methylparaben 0.05
(10) Appropriate amount of fragrance (11) Blue No. 403 0.0003
* 22: Kairei Marine Cholesterol (manufactured by Nippon Suisan Kaisha)
(Production method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. Phase A is added to phase B at 30 ° C., and the mixture is uniformly mixed and dispersed with a disperser mixer.

Example 35 Oil serum
(Ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 0.5
(2) Ceramide 3 (* 15) 0.5
(3) Ceramide 6 (* 16) 0.5
(4) Meadowfoam Estride (* 2) 2.0
(5) Squalene (* 12) 20.0
(Phase B)
(6) Phytosteryl isostearate 5.0
(7) Squalene 13.0
(8) Glyceryl tripalmitin 1.5
(9) Glyceryl tri2-heptylundecanoate 2.9
(10) Stearic acid 0.5
(11) Sarashi Beeswax 4.0
(12) Jojoba oil 1.0
(13) Cetyl 2-ethylhexanoate 28.0
(14) Meadowfoam oil 1.0
(15) Decamethylcyclopentasiloxane 5.0
(16) Pentaerythrit tetra2-ethylhexanoate 14.0
(17) d-δ-tocopherol 0.6
(Production method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. Phase A is added to phase B at 30 ° C., and the mixture is uniformly mixed and dispersed with a disperser mixer.

Example 36 Hand oil
(Ingredient name) Weight (%)
(Phase A)
(1) Ceramide 2 (* 1) 1.0
(2) Meadowfoam Estride (* 2) 1.0
(3) Dimethicone (* 23) 20.0
(Phase B)
(4) Cyclopentasiloxane 20.0
(5) Remaining amount of isostearyl isostearate (6) Isotridecyl isononanoate 50.0
(7) Vitamin E 0.1
(8) Macademia nut oil 1.0
(9) Jojoba oil 2.0
(10) Shea fat 3.0
(11) Appropriate amount of fragrance * 23: Silicone SH200 oil 30CS (manufactured by Toray Dow Corning Silicone)
(Production method)
1. 1. Phase A is uniformly heated and dissolved at 95 ° C. and cooled to 30 ° C.
2. Phase B is uniformly heated and dissolved at 90 ° C. and cooled to 30 ° C.
3. 3. Phase A is added to phase B at 30 ° C., and the mixture is uniformly mixed and dispersed with a homomixer.

In Examples 27 to 36, ceramide crystallization was not observed in the time-lapse observation at 40 ° C. for 6 months.

Claims (2)

The following components (A) to (C)
(A) Ceramide (B) Meadowfoam estride (C) Meadowfoam estride, which is an optically active substance, contains an oil that is liquid at 25 ° C., and the content of component (A) is 20.0% by weight or less. Moreover, the content of the component (B) is 0.2 to 2.0 times the content of the component (A), and 50.0% by weight or more of the oil agent of the component (C) is a non-polar oil. A non-aqueous gel-like composition having a lamellar liquid crystal structure in which the content of components other than the components (A) to (C) is 0.5% by weight or less. A cosmetic containing the non-aqueous gel composition according to claim 1 and containing no water.

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