JP6873624B2 - 腸内環境改善用組成物 - Google Patents
腸内環境改善用組成物 Download PDFInfo
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- JP6873624B2 JP6873624B2 JP2016153805A JP2016153805A JP6873624B2 JP 6873624 B2 JP6873624 B2 JP 6873624B2 JP 2016153805 A JP2016153805 A JP 2016153805A JP 2016153805 A JP2016153805 A JP 2016153805A JP 6873624 B2 JP6873624 B2 JP 6873624B2
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Images
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
項1.
β−クリプトキサンチンを含有する腸内環境改善用組成物。
項2.
β−クリプトキサンチンを含有する、プレボテラ属菌の腸内フローラ占有割合を高めるための組成物。
項3.
プレボテラ属菌の腸内フローラ占有割合を高めるための、項1に記載の組成物。
項4.
医薬品組成物又は食品組成物である、項1〜3のいずれかに記載の組成物。
最も好ましい。
動物種:マウス(SPF)
系統:C57BL/6J 日本チャールス・リバー株式会社
雄、4週齢
抗肥満効果のある素材として知られる、あしたばを対象に用いて、βクリプトキサンチンの効果を検討した。
・あした葉ポリフェノール(CALSAP): 株式会社日本生物化学研究所
・酵素処理温州ミカン β−クリプトキサンチン0.15%含有:株式会社ダイセル
普通食飼料:CRF−1、オリエンタル酵母工業株式会社
高脂肪食飼料:HFD−60、オリエンタル酵母工業株式会社
検疫・馴化期間及び群分け後の普通食群はCRF−1を給餌器に入れて自由に摂取させた。群分け後のその他の群はHFD−60を給餌器に入れ、自由に摂取させた。
群分け前日から当日、群分け後(すなわち試験開始から)25日〜26日、26日〜27日、及び投与27日〜28日に、各個体のケージ中の糞便を採取した。糞便を入れたチューブは超低温フリーザー中で凍結保存した。
糞便中の菌叢解析については、各検体の細菌叢に由来する16SrDNA部分塩基配列のT−RFLP(Terminal Restriction Fragment Length Polymorphism)解析を行い、得られたデータに基づいて検体中の主要な分類群の簡易的な推定およびクラスター解析による検体間の比較を実施した。なお、当該菌叢解析には、25日〜26日、26日〜27日、及び投与27日〜28日に、採取した糞便を混合したものを検体として用いた。また、解析は株式会社テクノスルガラボに依頼した。
解析ソフト:Gene Maths(Applied1Maths、Belgium)
クラスタリング方法:UPGMA
距離関数:ピアソンの相関関数
Claims (4)
- β−クリプトキサンチンを含有する、腸内フローラにおけるエンテロタイプがバクテロイデス属の比率が高い人のための、プレボテラ属菌の腸内フローラ占有割合を高めるための組成物。
- 医薬品組成物又は食品組成物である、請求項1に記載の組成物。
- 粉末飲料又は顆粒飲料である、請求項1又は2に記載の組成物。
- 野菜ゼリー又は野菜ジュースである、請求項1又は2に記載の組成物。
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JP2018020981A JP2018020981A (ja) | 2018-02-08 |
JP6873624B2 true JP6873624B2 (ja) | 2021-05-19 |
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP3433917B2 (ja) * | 2000-03-28 | 2003-08-04 | 明治乳業株式会社 | 体タンパク質蓄積効率を亢進する栄養組成物 |
CN102743420A (zh) * | 2012-06-06 | 2012-10-24 | 上海交通大学 | 改善肠道菌群结构的方法及应用 |
JPWO2014208511A1 (ja) * | 2013-06-27 | 2017-02-23 | 学校法人同志社 | アスタキサンチン含有腸内フローラ改善組成物 |
JP6148218B2 (ja) * | 2014-09-29 | 2017-06-14 | 株式会社ユーグレナ | 腎不全進行抑制剤、腎不全予防剤、尿毒症治療剤、インドキシル硫酸産生阻害剤、心血管系疾患予防剤、及び食品組成物 |
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