JP6838906B2 - Liquid bag quick freezing container - Google Patents
Liquid bag quick freezing container Download PDFInfo
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- JP6838906B2 JP6838906B2 JP2016185120A JP2016185120A JP6838906B2 JP 6838906 B2 JP6838906 B2 JP 6838906B2 JP 2016185120 A JP2016185120 A JP 2016185120A JP 2016185120 A JP2016185120 A JP 2016185120A JP 6838906 B2 JP6838906 B2 JP 6838906B2
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- 239000007788 liquid Substances 0.000 title claims description 207
- 238000007710 freezing Methods 0.000 title claims description 63
- 230000008014 freezing Effects 0.000 title claims description 63
- 229910052751 metal Inorganic materials 0.000 claims description 107
- 239000002184 metal Substances 0.000 claims description 107
- 239000000463 material Substances 0.000 claims description 13
- 229910052782 aluminium Inorganic materials 0.000 claims description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 5
- 229910000838 Al alloy Inorganic materials 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 52
- 229910052757 nitrogen Inorganic materials 0.000 description 26
- 238000002360 preparation method Methods 0.000 description 23
- 238000001816 cooling Methods 0.000 description 12
- 239000007789 gas Substances 0.000 description 11
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- -1 but for example Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- UFRKOOWSQGXVKV-UHFFFAOYSA-N ethene;ethenol Chemical compound C=C.OC=C UFRKOOWSQGXVKV-UHFFFAOYSA-N 0.000 description 1
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Description
本発明は、液体製剤等の液体を封入した液体用バッグを収容して急速凍結させるための液体用バッグの急速凍結用容器に関し、特に、収容した液体用バッグを低温液化ガスを用い急速凍結させ、冷凍保存することができる液体用バッグの急速凍結用容器に関する。 The present invention relates to a container for quick freezing of a liquid bag for containing and rapidly freezing a liquid bag containing a liquid such as a liquid preparation, and in particular, the contained liquid bag is rapidly frozen using a low-temperature liquefied gas. Regarding a container for quick freezing of a liquid bag that can be stored frozen.
液体製剤は、通常、菌の混入を防ぐ目的でケース内に密閉されている。液体製剤を密閉するためのケースとしては、一般に、図２に示すような２Ｄ（２次元、平面）状の樹脂フィルム製の液体用バッグが用いられる。
また、液体製剤は、その有効性と安全性を保持するため、所定の温度で冷蔵または冷凍保存されているのが一般的である。
Liquid formulations are usually sealed in a case to prevent contamination by bacteria. As a case for sealing the liquid preparation, a liquid bag made of a 2D (two-dimensional, flat) resin film as shown in FIG. 2 is generally used.
In addition, liquid preparations are generally refrigerated or frozen at a predetermined temperature in order to maintain their effectiveness and safety.
液体製剤を冷凍保存する場合においては、液体製剤中の抗原の残存率を高くすることが望まれており、液体製剤を冷却して凍結する際の冷却速度が高いほど、液体製剤中の抗原の残存率は高くなることが知られている。
液体製剤中の抗原の残存率と冷却速度との具体的な関係の一例を挙げると、抗原の残存率を90%以上とするためには、常温から冷却開始30分以内で−50℃、かつ常温から冷却開始50分以内で−90℃が目標冷却速度として要求されている。
When the liquid preparation is stored frozen, it is desired to increase the residual rate of the antigen in the liquid preparation. The higher the cooling rate when the liquid preparation is cooled and frozen, the more the antigen in the liquid preparation is stored. It is known that the survival rate is high.
To give an example of the specific relationship between the residual rate of antigen in a liquid preparation and the cooling rate, in order to make the residual rate of antigen 90% or more, it should be -50 ° C within 30 minutes from the start of cooling from room temperature. The target cooling rate is required to be -90 ° C within 50 minutes of the start of cooling from room temperature.
特許文献１には、密閉した容器に封入させた液体製剤を凍結させ、その後滅菌させる技術が開示されている。特許文献１では、凍結には一般的なフリーザーを用いてもよいし、液体窒素などの冷却冷媒を用いてもよい、とされている。 Patent Document 1 discloses a technique of freezing a liquid preparation sealed in a closed container and then sterilizing it. Patent Document 1 states that a general freezer may be used for freezing, or a cooling refrigerant such as liquid nitrogen may be used.
液体製剤の保存期間を長期化するため、液体製剤を冷凍保存することが求められているが、特許文献１に開示されている一般的なフリーザーによる凍結方法では、前述の目標冷却速度を満たして液体製剤の凍結を行うことができず、液体製剤中の抗原の残存率が低くなるという問題があった。 In order to prolong the storage period of the liquid preparation, it is required to freeze the liquid preparation, but the general freezing method using a freezer disclosed in Patent Document 1 satisfies the above-mentioned target cooling rate. There is a problem that the liquid preparation cannot be frozen and the residual rate of the antigen in the liquid preparation becomes low.
また、液体窒素を噴霧する凍結方法は、十分な冷却速度を得ることができるものの、液体用バッグにおいて噴霧された液体窒素が直接触れた位置が極低温となり、樹脂フィルム製の液体用バッグ自体が破損する問題があった。さらに、液体用バッグ内に密閉された液体は凍結すると膨張するため、凍結に偏りがあると液体用バッグが破損してしまう問題があった。 In addition, although the freezing method of spraying liquid nitrogen can obtain a sufficient cooling rate, the position where the sprayed liquid nitrogen comes into direct contact with the liquid nitrogen becomes extremely low, and the liquid bag itself made of resin film becomes extremely cold. There was a problem of breakage. Further, since the liquid sealed in the liquid bag expands when frozen, there is a problem that the liquid bag is damaged if the freezing is biased.
さらに、凍結した液体用バッグの保存方法として、従来は、凍結した液体用バッグを冷凍庫などでまとめて冷凍保存するのが一般的であったが、これにより樹脂フィルム製の液体用バッグ本体が破損したり、液体用バッグに設けられているチューブ接続部（図２参照）が折れたりする問題があった。 Furthermore, as a method of storing frozen liquid bags, conventionally, it has been common to store frozen liquid bags together in a freezer or the like, but this damages the main body of the liquid bag made of resin film. There was a problem that the tube connection portion (see FIG. 2) provided in the liquid bag was broken.
本発明は、上記のような課題を解決するためになされたものであり、液体製剤等の液体が封入された液体用バッグを急速冷凍するに際し、液体用バッグを破損させることなく、該液体用バッグに封入された液体を短時間で一律に凍結させることが可能であり、かつ凍結したバッグが破損することなく冷凍保存が可能な液体用バッグの急速凍結用容器を提供することを目的とする。 The present invention has been made to solve the above-mentioned problems, and when a liquid bag containing a liquid such as a liquid preparation is rapidly frozen, the liquid bag is not damaged and is used for the liquid. It is an object of the present invention to provide a container for rapid freezing of a liquid bag which can uniformly freeze the liquid enclosed in the bag in a short time and can be frozen and stored without damaging the frozen bag. ..
（１）本発明に係る液体用バッグの急速凍結用容器は、本体部と該本体部にチューブ接続部が設けられて液体を封入した液体用バッグを収容し、低温液化ガスを用いて急速凍結させるためのものであって、前記液体用バッグを収容するバッグ収容部が、金属板と、該金属板に対向配置された対向板と、前記金属板と前記対向板を所定の間隔を離した状態で連結する側壁部とを備えてなり、前記金属板の外面は、前記低温液化ガスと接触して冷却され、前記金属板の内面は、前記バッグ収容部に前記液体用バッグを収容した状態で前記液体用バッグの本体部に当接することを特徴とするものである。 (1) The container for rapid freezing of a liquid bag according to the present invention accommodates a liquid bag in which a main body and a tube connection portion are provided in the main body and contains a liquid, and is rapidly frozen using a low-temperature liquefied gas. The bag accommodating portion for accommodating the liquid bag separates the metal plate, the facing plate arranged to face the metal plate, and the metal plate and the facing plate from each other at a predetermined distance. The outer surface of the metal plate is cooled in contact with the low-temperature liquefied gas, and the inner surface of the metal plate is in a state where the liquid bag is housed in the bag storage part. It is characterized in that it comes into contact with the main body of the liquid bag.
（２）上記（１）に記載のものにおいて、前記バッグ収容部に前記液体用バッグを収容した状態で、前記金属板の内面における前記液体用バッグのチューブ接続部に対向する部位に、前記金属板よりも熱伝導性の低い材質をコーティングしたことを特徴とするものである。 (2) In the above-described item (1), the metal is placed on the inner surface of the metal plate facing the tube connection portion of the liquid bag in a state where the liquid bag is housed in the bag accommodating portion. It is characterized by being coated with a material having a lower thermal conductivity than a plate.
（３）上記（１）又は（２）に記載のものにおいて、前記金属板と前記対向板が共に平板からなり、両者が互いに平行になるように配置されていることを特徴とするものである。 (3) In the above-mentioned (1) or (2), the metal plate and the facing plate are both made of a flat plate, and both are arranged so as to be parallel to each other. ..
（４）上記（１）乃至（３）のいずれかに記載のものにおいて、前記対向板は、金属製であることを特徴とするものである。 (4) In any of the above (1) to (3), the facing plate is made of metal.
（５）上記（４）に記載のものにおいて、前記金属板及び前記対向板は、アルミニウム又はアルミニウム合金製であることを特徴とするものである。 (5) In the above-mentioned item (4), the metal plate and the facing plate are made of aluminum or an aluminum alloy.
（６）上記（４）又は（５）に記載のものにおいて、
前記対向板及び前記側壁部は、前記金属板と同じ材質の金属で形成されていることを特徴とするものである。
(6) In the above-mentioned (4) or (5),
The facing plate and the side wall portion are made of a metal of the same material as the metal plate.
（７）上記（１）乃至（６）のいずれかに記載のものにおいて、前記側壁部は、前記金属板側と前記対向板側に分割され、当該分割される部位において嵌合可能になっていることを特徴とするものである。 (7) In any of the above (1) to (6), the side wall portion is divided into the metal plate side and the facing plate side, and can be fitted at the divided portion. It is characterized by being present.
（８）上記（１）乃至（７）のいずれかに記載のものにおいて、前記金属板の外面に低温液化ガスを貯留できる貯留部を有することを特徴とするものである。 (8) The item according to any one of (1) to (7) above, characterized in that the outer surface of the metal plate has a storage portion capable of storing low-temperature liquefied gas.
（９）上記（１）乃至（８）のいずれかに記載のものにおいて、前記金属板の内面側における前記液体用バッグの本体部が当接する部位に温度測定手段を設けたことを特徴とするものである。 (9) In any of the above (1) to (8), the temperature measuring means is provided at a portion of the inner surface side of the metal plate where the main body of the liquid bag abuts. It is a thing.
本発明の液体用バッグの急速凍結用容器は、前記液体用バッグを収容するバッグ収容部が、金属板と、該金属板に対向配置された対向板と、前記金属板と前記対向板を所定の間隔を離した状態で連結する側壁部とを備えてなり、前記金属板の外面は、前記低温液化ガスと接触して冷却され、前記金属板の内面は、前記バッグ収容部に前記液体用バッグを収容した状態で前記液体用バッグの本体部に当接するようにしたので、前記液体用バッグを収容して冷却する際に、前記液体用バッグの本体部の表面に均一に低温液化ガスの冷熱が伝わり、前記液体用バッグを破損させることなく前記液体用バッグに封入された液体を短時間で均一に凍結することができる。さらに、凍結した液体用バッグを収容した状態のまま冷凍庫などで冷凍保存することができ、液体用バッグの破損を防ぐことができる。 In the container for rapid freezing of the liquid bag of the present invention, the bag accommodating portion for accommodating the liquid bag defines a metal plate, a facing plate arranged to face the metal plate, and the metal plate and the facing plate. The outer surface of the metal plate is cooled in contact with the low-temperature liquefied gas, and the inner surface of the metal plate is used for the liquid in the bag accommodating portion. Since the liquid bag is brought into contact with the main body of the liquid bag in the state of being housed, when the liquid bag is housed and cooled, the low temperature liquefied gas is uniformly applied to the surface of the main body of the liquid bag. Cold heat is transmitted, and the liquid enclosed in the liquid bag can be uniformly frozen in a short time without damaging the liquid bag. Further, the frozen liquid bag can be stored frozen in a freezer or the like while being housed, and the liquid bag can be prevented from being damaged.
本発明の実施の形態に係る液体用バッグの急速凍結用容器１（以下、単に「急速凍結用容器１」という）は、図１に一例として示すように、本体部３３と本体部３３にチューブ接続部３５が設けられて液体製剤を封入した液体用バッグ３１を収容し、液体窒素を用いて急速凍結させるためのものであって、液体用バッグ３１を収容するバッグ収容部３が、第１金属平板５と、第２金属平板７と、側壁部９とを備えてなるものである。以下、液体用バッグ３１について説明した後に、急速凍結用容器１の各構成要素を詳細に説明する。 The container 1 for rapid freezing of the liquid bag according to the embodiment of the present invention (hereinafter, simply referred to as “container 1 for rapid freezing”) has tubes in the main body 33 and the main body 33, as shown as an example in FIG. The bag accommodating portion 3 for accommodating the liquid bag 31 provided with the connecting portion 35 and enclosing the liquid preparation and rapidly freezing it with liquid nitrogen, and accommodating the liquid bag 31 is the first. It includes a metal flat plate 5, a second metal flat plate 7, and a side wall portion 9. Hereinafter, after the liquid bag 31 has been described, each component of the quick freezing container 1 will be described in detail.
なお、以下の説明で用いる図面は、本発明の実施の形態に係る構成の特徴をわかりやすくするために、便宜上特徴となる部分を拡大して示している場合があり、図示される各構成要素の大きさ、厚さ、寸法などは、実際の寸法比率などと同じであるとは限らない。
また、本明細書および図面において、実質的に同一の機能を有する要素については、同一の符号を付することにより、重複説明を省略する。
In addition, in the drawing used in the following description, in order to make it easy to understand the feature of the configuration according to the embodiment of the present invention, the feature portion may be enlarged for convenience, and each component shown in the drawing may be enlarged. The size, thickness, dimensions, etc. of are not always the same as the actual dimensional ratios.
Further, in the present specification and the drawings, elements having substantially the same function are designated by the same reference numerals, so that duplicate description will be omitted.
液体用バッグ３１は、図２に示すように、２Ｄ（二次元、平面）状のものであり、チューブ接続部３５には、チューブ３７が接続されている。液体用バッグ３１は、樹脂フィルム製である。
液体用バッグ３１は、被凍結物として液体製剤を封入したものであるが、被凍結物として液体用バッグ３１に封入するものとしては液体製剤に限るものではない。
As shown in FIG. 2, the liquid bag 31 has a 2D (two-dimensional, planar) shape, and the tube 37 is connected to the tube connecting portion 35. The liquid bag 31 is made of a resin film.
The liquid bag 31 contains a liquid preparation as an object to be frozen, but the bag 31 to be enclosed in the liquid bag 31 as an object to be frozen is not limited to the liquid preparation.
第１金属平板５は、バッグ収容部３に液体用バッグ３１を収容した状態でその内面５ａが液体用バッグ３１の本体部３３と当接し、また、外面５ｂには上方から噴霧された液体窒素が接触して冷却される。 The inner surface 5a of the first metal flat plate 5 abuts the main body 33 of the liquid bag 31 in a state where the liquid bag 31 is housed in the bag accommodating portion 3, and the outer surface 5b is sprayed with liquid nitrogen from above. Is in contact and cooled.
第２金属平板７は、第１金属平板５に対向配置される対向板として設けられたものであり、第１金属平板５と第２金属平板７の両者が互いに平行になるように配置されている。
そして、第１金属平板５と同様に、バッグ収容部３に液体用バッグ３１を収容した状態でその内面７ａが液体用バッグ３１の本体部３３と当接する。
対向板として金属製の第２金属平板７を設けることにより、液体用バッグ３１の本体部３３を均一に冷却するのに好ましい。
The second metal flat plate 7 is provided as a facing plate which is arranged to face the first metal flat plate 5, and both the first metal flat plate 5 and the second metal flat plate 7 are arranged so as to be parallel to each other. There is.
Then, similarly to the first metal flat plate 5, the inner surface 7a of the liquid bag 31 is brought into contact with the main body 33 of the liquid bag 31 in a state where the liquid bag 31 is housed in the bag storage portion 3.
By providing the second metal flat plate 7 made of metal as the facing plate, it is preferable to uniformly cool the main body 33 of the liquid bag 31.
側壁部９は、第１金属平板５と第２金属平板７を所定の間隔を離した状態で連結するものであり、図１においては、側壁部９の上端部には蝶番１１を介して第１金属平板５が開閉可能に接続され、第１金属平板５を上方に開くことで、バッグ収容部３に液体用バッグ３１を収容することができる。 The side wall portion 9 connects the first metal flat plate 5 and the second metal flat plate 7 in a state of being separated from each other by a predetermined distance, and in FIG. 1, the upper end portion of the side wall portion 9 is connected to the upper end portion of the side wall portion 9 via a hinge 11. 1 The metal flat plate 5 is connected so as to be openable and closable, and by opening the first metal flat plate 5 upward, the liquid bag 31 can be accommodated in the bag accommodating portion 3.
また、第２金属平板７と側壁部９は、第１金属平板５と第２金属平板７との間で熱が伝わるように、第１金属平板５と同じ材質の金属で形成されることが好ましく、アルミニウム製又はアルミニウム合金製が特に好ましい。
本実施の形態では、第１金属平板５、第２金属平板７および側壁部９として板厚2mmのアルミニウム製の平板を用いている。
Further, the second metal flat plate 7 and the side wall portion 9 may be formed of a metal of the same material as the first metal flat plate 5 so that heat is transferred between the first metal flat plate 5 and the second metal flat plate 7. It is preferably made of aluminum or an aluminum alloy, particularly preferably.
In the present embodiment, an aluminum flat plate having a plate thickness of 2 mm is used as the first metal flat plate 5, the second metal flat plate 7, and the side wall portion 9.
図１においては、バッグ収容部３に液体用バッグ３１を収容した状態で、第１金属平板５および第２金属平板７それぞれの内面５ａおよび７ａは、液体用バッグ３１の本体部３３の表面と接触している。 In FIG. 1, with the liquid bag 31 housed in the bag accommodating portion 3, the inner surfaces 5a and 7a of the first metal flat plate 5 and the second metal flat plate 7 are respectively the surface of the main body 33 of the liquid bag 31. Are in contact.
一方、液体用バッグ３１のチューブ接続部３５や、チューブ接続部３５に接続されたチューブ３７などは、急速凍結させると破損しやすいことから、これらの部分は急速凍結しないように、少なくとも第１金属平板５と接触しないように第１金属平板５との間に空間が設けられている。 On the other hand, the tube connecting portion 35 of the liquid bag 31 and the tube 37 connected to the tube connecting portion 35 are easily damaged by quick freezing. Therefore, at least the first metal is prevented from rapidly freezing these parts. A space is provided between the first metal flat plate 5 and the flat plate 5 so as not to come into contact with the flat plate 5.
そして、第１金属平板５の外面５ｂに液体窒素を噴霧すると、液体窒素の冷熱が瞬時に第１金属平板５と、側壁部９を介して第２金属平板７に均等に広がり、チューブ接続部３５やチューブ３７などには冷熱を伝えず、液体用バッグ３１の本体部３３の上下両面に効率よく冷熱を伝えることができ、チューブ接続部３５など破損しやすい部分が急速凍結しないように液体用バッグ３１を平面的かつ均等に冷やすことができる。 Then, when liquid nitrogen is sprayed on the outer surface 5b of the first metal flat plate 5, the cold heat of the liquid nitrogen instantly spreads evenly to the first metal flat plate 5 and the second metal flat plate 7 via the side wall portion 9, and the tube connection portion. Cold heat is not transmitted to 35 and the tube 37, but cold heat can be efficiently transmitted to both the upper and lower sides of the main body 33 of the liquid bag 31, and for liquid so that fragile parts such as the tube connection 35 do not freeze rapidly. The bag 31 can be cooled flatly and evenly.
液体用バッグ３１に液体窒素などの低温液化ガスを直接噴霧すると、低温液化ガスが直接触れた位置が局所的に極低温となることで樹脂フィルム製の液体用バッグ３１自体が破損したり、液体用バッグ３１内に封入された液体製剤が部分的に凍結したりすることで液体用バッグ３１が局部的に膨張して破損したりするといった問題があったが、本実施の形態に係る急速凍結用容器１においては、液体用バッグ３１に液体窒素を直接接触させずに第１金属平板５を介して液体製剤を冷却するため、液体用バッグ３１の破損を防ぐことができる。
また、第１金属平板５と第２金属平板７とが平行であるため、多数の急速凍結用容器１をフリーザーなどに収容する際に収納効率が良く、また、取り出しを容易にできる。
When a low-temperature liquefied gas such as liquid nitrogen is directly sprayed onto the liquid bag 31, the position where the low-temperature liquefied gas comes into direct contact becomes locally extremely low, causing the resin film liquid bag 31 itself to be damaged or the liquid to be liquid. There is a problem that the liquid preparation enclosed in the liquid bag 31 is partially frozen and the liquid bag 31 is locally expanded and damaged. However, the rapid freezing according to the present embodiment is performed. In the liquid container 1, since the liquid preparation is cooled through the first metal flat plate 5 without directly contacting the liquid nitrogen with the liquid bag 31, damage to the liquid bag 31 can be prevented.
Further, since the first metal flat plate 5 and the second metal flat plate 7 are parallel to each other, the storage efficiency is good when a large number of quick freezing containers 1 are stored in a freezer or the like, and the containers can be easily taken out.
また、凍結した液体用バッグ３１をフリーザーなどで冷凍保存する際においては、チューブ接続部３５やチューブ３７が破損しやすいが、凍結した液体用バッグ３１を収容した状態で急速凍結用容器１をフリーザーなどに冷凍保存する場合、バッグ収容部３においてはチューブ接続部３５およびチューブ３７と第１金属平板５および第２金属平板７との間に空間が設けられていることで、チューブ接続部３５およびチューブ３７の破損を防ぐことができる。 Further, when the frozen liquid bag 31 is frozen and stored in a freezer or the like, the tube connection portion 35 and the tube 37 are easily damaged, but the rapid freezing container 1 is frozen in the state where the frozen liquid bag 31 is housed. In the case of frozen storage in the bag accommodating portion 3, a space is provided between the tube connecting portion 35 and the tube 37 and the first metal flat plate 5 and the second metal flat plate 7 in the bag accommodating portion 3, so that the tube connecting portion 35 and the tube connecting portion 35 and the second metal flat plate 7 are provided with a space. It is possible to prevent the tube 37 from being damaged.
上記のように、急速凍結用容器１においてはチューブ接続部３５やチューブ３７が第１金属平板５と接触しないように空間が設けられているが、バッグ収容部３に液体用バッグ３１を収容した状態で、第１金属平板５の内面５ａにおける液体用バッグ３１のチューブ接続部３５に対向する部位に第１金属平板５よりも熱伝導性の低い材質（例えば、樹脂など）をコーティングすることによって、チューブ接続部３５およびチューブ３７の急速凍結をさらに防止することができる。 As described above, in the rapid freezing container 1, a space is provided so that the tube connecting portion 35 and the tube 37 do not come into contact with the first metal flat plate 5, but the bag accommodating portion 3 accommodates the liquid bag 31. In this state, by coating a portion of the inner surface 5a of the first metal flat plate 5 facing the tube connection portion 35 of the liquid bag 31 with a material having a lower thermal conductivity than that of the first metal flat plate 5 (for example, resin). , The rapid freezing of the tube connection 35 and the tube 37 can be further prevented.
同様に、第２金属平板７の内面７ａにおいても、バッグ収容部３に液体用バッグ３１を収容した状態で、液体用バッグ３１のチューブ接続部３５に対向する部位に、熱伝導性の低い材質をコーティングすることが望ましい。 Similarly, also on the inner surface 7a of the second metal flat plate 7, a material having low thermal conductivity is provided at a portion of the liquid bag 31 facing the tube connection portion 35 in a state where the liquid bag 31 is accommodated in the bag accommodating portion 3. It is desirable to coat.
さらに、図１に示すように、第１金属平板５の外面５ｂに低温液化ガスを貯留する貯留部１３を設け、外面５ｂに向けて噴霧された液体窒素を貯留することにより、噴霧された液体窒素の冷熱を使用することができ、液体窒素の消費量を低減することや、液体製剤の凍結時間を短縮することができる。 Further, as shown in FIG. 1, a storage unit 13 for storing low-temperature liquefied gas is provided on the outer surface 5b of the first metal flat plate 5, and the sprayed liquid is stored by storing the liquid nitrogen sprayed toward the outer surface 5b. The cold heat of nitrogen can be used, the consumption of liquid nitrogen can be reduced, and the freezing time of the liquid preparation can be shortened.
図１に示す急速凍結用容器１においては、第１金属平板５の内面５ａと液体用バッグ３１とが接触する部位に温度測定手段として温度測定器１５が設けられている。
温度測定器１５は、液体用バッグ３１の表面温度を測定し、該測定した表面温度に基づいて急速凍結用容器１に噴霧する液体窒素の量を制御することができる。
本実施の形態では、温度測定器１５として熱電対を用いたが、これに限定されることではなく、常温から極低温までの温度範囲で測定できるものであれば良い。
In the quick freezing container 1 shown in FIG. 1, a temperature measuring device 15 is provided as a temperature measuring means at a portion where the inner surface 5a of the first metal flat plate 5 and the liquid bag 31 come into contact with each other.
The temperature measuring device 15 can measure the surface temperature of the liquid bag 31 and control the amount of liquid nitrogen sprayed on the quick freezing container 1 based on the measured surface temperature.
In the present embodiment, a thermocouple is used as the temperature measuring device 15, but the present invention is not limited to this, and any thermocouple that can measure in a temperature range from room temperature to extremely low temperature may be used.
本発明に係る液体用バッグの急速凍結用容器の他の態様として、図３に示すように、側壁部２３が第１金属平板５側と第２金属平板７側に分割され、第１金属平板５側の蓋部２５と、第２金属平板７側の容器部２７とが嵌合可能な急速凍結用容器２１が挙げられる。 As another aspect of the container for rapid freezing of the liquid bag according to the present invention, as shown in FIG. 3, the side wall portion 23 is divided into the first metal flat plate 5 side and the second metal flat plate 7 side, and the first metal flat plate Examples thereof include a container 21 for rapid freezing in which the lid portion 25 on the 5 side and the container portion 27 on the side of the second metal flat plate 7 can be fitted.
急速凍結用容器２１においても、バッグ収容部３に収容した液体用バッグ３１の本体部３３の表面に均一に低温液化ガスの冷熱が伝わり、液体用バッグ３１に封入された液体を短時間で均一に凍結することができ、また、凍結した液体用バッグ３１を収容した状態のまま冷凍庫などで冷凍保存する場合においても、液体用バッグ３１の破損を防ぐことができる。 Even in the rapid freezing container 21, the cold heat of the low-temperature liquefied gas is uniformly transmitted to the surface of the main body 33 of the liquid bag 31 housed in the bag housing 3, and the liquid sealed in the liquid bag 31 is uniformly spread in a short time. In addition, the liquid bag 31 can be prevented from being damaged even when the frozen liquid bag 31 is stored frozen in a freezer or the like while being housed in the frozen liquid bag 31.
さらに、急速凍結用容器２１においては、急速凍結用容器２１内に収容される液体用バッグ３１の厚さに合わせて、第１金属平板５と、第２金属平板７との間隔を容易に調整することができる。 Further, in the quick freezing container 21, the distance between the first metal flat plate 5 and the second metal flat plate 7 can be easily adjusted according to the thickness of the liquid bag 31 housed in the quick freezing container 21. can do.
また、凍結中に液体用バッグ３１に封入された液体製剤が膨張して本体部３３の厚さが増加した場合においても、蓋部２５と容器部２７とが嵌合した状態のままずれて第１金属平板５と第２金属平板７との間隔が増加し、液体用バッグ３１に過大な圧力がかからず、液体用バッグ３１の破損などを防止できる。
換言すれば、蓋部２５と容器部２７との嵌合は、分割する側壁部２３において蓋部２５と容器部２７とが接触したままずれることができる程度の強さであることが好ましい。
Further, even when the liquid preparation enclosed in the liquid bag 31 expands during freezing and the thickness of the main body 33 increases, the lid 25 and the container 27 are displaced while being fitted. The distance between the 1 metal flat plate 5 and the 2nd metal flat plate 7 is increased, excessive pressure is not applied to the liquid bag 31, and damage to the liquid bag 31 can be prevented.
In other words, the fitting between the lid portion 25 and the container portion 27 is preferably strong enough to allow the lid portion 25 and the container portion 27 to come into contact with each other at the side wall portion 23 to be divided.
なお、急速凍結用容器２１は、蓋部２５が容器部２７に嵌合し、側壁部２３における蓋部２５と容器部２７とが重なる部位で冷熱が伝わるように接触するものであったが、側壁部２３における蓋部２５と容器部２７との重なる部位はインロー構造であっても良い。 In the quick freezing container 21, the lid portion 25 was fitted to the container portion 27, and the lid portion 25 and the container portion 27 on the side wall portion 23 were in contact with each other so as to transfer cold heat. The portion of the side wall portion 23 where the lid portion 25 and the container portion 27 overlap may have an in-row structure.
また、急速凍結用容器２１においては、前述の急速凍結用容器１と同様に、第１金属平板５の内面５ａと液体用バッグ３１との間に温度測定手段を設けたものであっても良く、該温度測定手段により測定した温度に基づいて、第１金属平板５の外面５ｂに噴霧する液体窒素の量を制御することができる。 Further, in the quick freezing container 21, similarly to the above-mentioned quick freezing container 1, a temperature measuring means may be provided between the inner surface 5a of the first metal flat plate 5 and the liquid bag 31. The amount of liquid nitrogen sprayed on the outer surface 5b of the first metal flat plate 5 can be controlled based on the temperature measured by the temperature measuring means.
上記の急速凍結用容器１および急速凍結用容器２１に係る説明において、第１金属平板５と第２金属平板７は、互いに平行になるように配置された平板であるが、本発明に係る金属板および対向板はこれに限るものではなく、金属板と対向板とを備えてなるバッグ収容部が図２に示すような液体用バッグ３１を収容することができ、かつ少なくとも金属板の内面が液体用バッグ３１の本体部３３に当接するものであれば良い。 In the above description of the container 1 for rapid freezing and the container 21 for rapid freezing, the first metal flat plate 5 and the second metal flat plate 7 are flat plates arranged so as to be parallel to each other, but the metal according to the present invention. The plate and the facing plate are not limited to this, and the bag accommodating portion including the metal plate and the facing plate can accommodate the liquid bag 31 as shown in FIG. 2, and at least the inner surface of the metal plate is Anything that comes into contact with the main body 33 of the liquid bag 31 may be used.
また、上記の説明では、第１金属平板５、第２金属平板７および側壁部９は全てアルミニウム又はアルミニウム合金製、若しくは、金属製であることが好ましいものとしていたが、第１金属平板５、第２金属平板７および側壁部９の材質はこれに限定されるものではなく、強度を有し、低温に耐えるものであれば適宜使用することができ、熱伝導性の良い材質であることが望ましい。
さらに、本発明に係る急速凍結容器は、第１金属平板５に対応する「金属板」のみが金属製であり、他の対向板および側壁部が金属製でないものを含む。
Further, in the above description, it is preferable that the first metal flat plate 5, the second metal flat plate 7, and the side wall portion 9 are all made of aluminum or an aluminum alloy, or metal, but the first metal flat plate 5, The materials of the second metal flat plate 7 and the side wall portion 9 are not limited to this, and can be appropriately used as long as they have strength and can withstand low temperatures, and are materials having good thermal conductivity. desirable.
Further, the quick freezing container according to the present invention includes a container in which only the "metal plate" corresponding to the first metal flat plate 5 is made of metal, and the other facing plate and the side wall portion are not made of metal.
なお、上記の説明において、低温液化ガスとして液体窒素を噴霧して冷却していたが、例えば液体窒素を滴下して冷却するものであってもよく、液体窒素が液体用バッグに直接接触しないものであれば、急速凍結用容器と液体窒素との接触方法には特に限定はない。 In the above description, liquid nitrogen is sprayed and cooled as a low-temperature liquefied gas, but for example, liquid nitrogen may be dropped and cooled, and the liquid nitrogen does not come into direct contact with the liquid bag. If so, the contact method between the rapid freezing container and liquid nitrogen is not particularly limited.
本発明に係る液体用バッグの急速凍結用容器の効果を確認するための具体的な実験を行ったので、その結果について以下に説明する。 A specific experiment was conducted to confirm the effect of the container for quick freezing of the liquid bag according to the present invention, and the results will be described below.
実験は、図１に示す急速凍結用容器１に液体用バッグ３１を収容した状態で急速凍結用容器１を冷却し、液体用バッグ３１に封入した液体を凍結させた。 In the experiment, the quick freezing container 1 was cooled with the liquid bag 31 housed in the quick freezing container 1 shown in FIG. 1, and the liquid sealed in the liquid bag 31 was frozen.
液体用バッグ３１には、２Ｄ（二次元、平面）状の医療用バッグ（ポール社製、容量：3L、材質：LDPE+PE+EVOHの積層構造）を用いた。
液体用バッグ３１に封入して凍結させる液体として、ワクチン模擬液2.5Lを用いた。また、液体用バッグ３１のチューブ接続部３５には、チューブ３７（材質：PE）を接続した。
As the liquid bag 31, a 2D (two-dimensional, flat) medical bag (manufactured by Paul, capacity: 3 L, material: LDPE + PE + EVOH laminated structure) was used.
2.5 L of the vaccine simulated solution was used as the liquid to be sealed in the liquid bag 31 and frozen. Further, a tube 37 (material: PE) was connected to the tube connection portion 35 of the liquid bag 31.
本実施例では、発明例として、液体用バッグ３１を収容した急速凍結用容器１の第１金属平板５の外面５ｂに液体窒素を噴霧して冷却し、液体用バッグ３１中の液体を凍結させた。このとき、温度測定器１５による温度測定値を基に外面５ｂに噴霧する液体窒素の噴霧量を制御しつつ、液体用バッグ３１に封入した液体を凍結させた。 In this embodiment, as an example of the invention, liquid nitrogen is sprayed on the outer surface 5b of the first metal flat plate 5 of the quick freezing container 1 containing the liquid bag 31 to cool it, and the liquid in the liquid bag 31 is frozen. It was. At this time, the liquid sealed in the liquid bag 31 was frozen while controlling the amount of liquid nitrogen sprayed on the outer surface 5b based on the temperature measured value by the temperature measuring device 15.
さらに、比較例として、液体用バッグ３１を予め設定温度（-120℃）に冷やされた液体窒素式フリーザーの冷凍室内に直接収納し、液体用バッグ３１中の液体を凍結させた。比較例において、液体用バッグ３１の材質、液体用バッグ３１に封入した液体、および、チューブ３７には、上記の発明例と同一のものを使用した。液体窒素式フリーザーは、常に冷凍室内が設定温度-120℃で一定となるように液体窒素を噴霧した。このとき、液体窒素が液体用バッグ３１およびチューブ３７に直接噴霧されないようにした。 Further, as a comparative example, the liquid bag 31 was directly stored in the freezing chamber of a liquid nitrogen freezer cooled to a preset temperature (-120 ° C.), and the liquid in the liquid bag 31 was frozen. In the comparative example, the same material as the above-mentioned invention example was used for the material of the liquid bag 31, the liquid sealed in the liquid bag 31, and the tube 37. The liquid nitrogen freezer was always sprayed with liquid nitrogen so that the temperature inside the freezer was constant at the set temperature of -120 ° C. At this time, liquid nitrogen was prevented from being directly sprayed on the liquid bag 31 and the tube 37.
発明例および比較例ともに、液体用バッグ３１を所定の温度（-50℃および-90℃）まで冷却するのに要する所要時間を計測し、液体を凍結させた液体用バッグ３１およびチューブ３７の破損状況を観察した。 In both the invention example and the comparative example, the time required to cool the liquid bag 31 to a predetermined temperature (-50 ° C. and −90 ° C.) was measured, and the liquid bag 31 and the tube 37 in which the liquid was frozen were damaged. I observed the situation.
本実施例における結果は以下のとおりであった。
まず、発明例においては、液体用バッグ３１およびチューブ３７に破損を生じさせずに、液体用バッグ３１に封入した液体を凍結させることができた。
そして、所定の常温（+5℃）から-50℃まで冷却するのに要した所要時間は18分、常温から-90℃までの所要時間は27分であった。
The results in this example were as follows.
First, in the example of the invention, the liquid sealed in the liquid bag 31 could be frozen without causing damage to the liquid bag 31 and the tube 37.
The time required for cooling from a predetermined room temperature (+ 5 ° C) to -50 ° C was 18 minutes, and the time required from room temperature to -90 ° C was 27 minutes.
前述のとおり、液体製剤を冷凍保存する場合において、液体製剤中の抗原の残存率を90%以上とするための目標冷却速度として、常温から-50℃まで30分以内、かつ常温から-90℃まで50分以内で冷却することが要求されている。発明例で得られた結果は、当該目標冷却速度を達成するものであった。 As described above, when the liquid preparation is stored frozen, the target cooling rate for keeping the residual rate of antigen in the liquid preparation at 90% or more is within 30 minutes from room temperature to -50 ° C and from room temperature to -90 ° C. It is required to cool within 50 minutes. The result obtained in the invention example was to achieve the target cooling rate.
一方、比較例においても、液体窒素が液体用バッグ３１およびチューブ３７に直接噴霧されなかったことで、液体用バッグ３１およびチューブ３７に破損を生じさせずに液体用バッグ３１に封入した液体を凍結させることができた。しかしながら、常温（+5℃）から-50℃まで冷却するのに要した所要時間は66分、常温から-90℃までの所要時間は81分であり、前述の目標冷却速度を達成することができなかった。 On the other hand, also in the comparative example, since the liquid nitrogen was not directly sprayed on the liquid bag 31 and the tube 37, the liquid sealed in the liquid bag 31 was frozen without causing damage to the liquid bag 31 and the tube 37. I was able to make it. However, the time required to cool from room temperature (+ 5 ° C) to -50 ° C is 66 minutes, and the time required from room temperature to -90 ° C is 81 minutes, and the above-mentioned target cooling rate can be achieved. could not.
以上、本発明に係る液体用バッグの急速凍結用容器によれば、液体用バッグを破損させずに該液体用バッグに封入した液体を急速凍結できることが実証された。 As described above, according to the container for quick freezing of the liquid bag according to the present invention, it has been demonstrated that the liquid enclosed in the liquid bag can be quickly frozen without damaging the liquid bag.
１ 急速凍結用容器
３ バッグ収容部
５ 第１金属平板
５ａ 内面
５ｂ 外面
７ 第２金属平板
７ａ 内面
９ 側壁部
１１ 蝶番
１３ 貯留部
１５ 温度測定器
２１ 急速凍結用容器
２３ 側壁部
２５ 蓋部
２７ 容器部
３１ 液体用バッグ
３３ 本体部
３５ チューブ接続部
３７ チューブ
1 Rapid freezing container 3 Bag accommodating part 5 1st metal flat plate 5a Inner surface 5b Outer surface 7 2nd metal flat plate 7a Inner surface 9 Side wall part 11 Hinge 13 Storage part 15 Temperature measuring instrument 21 Rapid freezing container 23 Side wall part 25 Lid part 27 Container Part 31 Liquid bag 33 Body part 35 Tube connection part 37 Tube
Claims (9)
前記液体用バッグを収容するバッグ収容部が、金属板と、該金属板に対向配置された対向板と、前記金属板と前記対向板を所定の間隔を離した状態で連結する側壁部とを備えてなり、
前記金属板の外面は、噴霧又は滴下した低温液化ガスを貯留できる貯留部を有し、貯留された低温液化ガスと接触して冷却され、
前記金属板の内面は、前記バッグ収容部に前記液体用バッグを収容した状態で前記液体用バッグの本体部に当接することを特徴とする液体用バッグの急速凍結用容器。 A liquid bag for rapidly freezing the liquid bag by spraying or dropping a low-temperature liquefied gas on the outer surface of the container to accommodate a liquid bag in which a tube connection portion is provided in the main body and the main body and is filled with a liquid. It is a container for rapid freezing of
The bag accommodating portion for accommodating the liquid bag comprises a metal plate, a facing plate arranged to face the metal plate, and a side wall portion connecting the metal plate and the facing plate at a predetermined distance. Be prepared
The outer surface of the metal plate has a storage portion capable of storing the sprayed or dropped low-temperature liquefied gas, and is cooled in contact with the stored low-temperature liquefied gas.
A container for quick freezing of a liquid bag, wherein the inner surface of the metal plate comes into contact with the main body of the liquid bag in a state where the liquid bag is housed in the bag storage portion.
前記液体用バッグを収容するバッグ収容部が、金属板と、該金属板に対向配置された対向板と、前記金属板と前記対向板を所定の間隔を離した状態で連結する側壁部とを備えてなり、
前記金属板の外面は、前記低温液化ガスと接触して冷却され、
前記金属板の内面は、前記バッグ収容部に前記液体用バッグを収容した状態で前記液体用バッグの本体部に当接し、
前記バッグ収容部に前記液体用バッグを収容した状態で、前記金属板の内面における前記液体用バッグのチューブ接続部に対向する部位に、前記金属板よりも熱伝導性の低い材質をコーティングしたことを特徴とする液体用バッグの急速凍結用容器。 A container for quick freezing of a liquid bag for accommodating a liquid bag in which a tube connection portion is provided in the main body and the main body and containing a liquid, and for quick freezing using a cryogenic liquefied gas.
The bag accommodating portion for accommodating the liquid bag comprises a metal plate, a facing plate arranged to face the metal plate, and a side wall portion connecting the metal plate and the facing plate at a predetermined distance. Be prepared
The outer surface of the metal plate is cooled by coming into contact with the cryogenic liquefied gas.
The inner surface of the metal plate comes into contact with the main body of the liquid bag in a state where the liquid bag is housed in the bag accommodating portion.
With the liquid bag housed in the bag accommodating portion, a portion of the inner surface of the metal plate facing the tube connection portion of the liquid bag is coated with a material having a lower thermal conductivity than the metal plate. A container for rapid freezing of liquid bags.
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