JP6818924B1 - Method for improving nontuberculous mycobacteriosis using slaked lime - Google Patents

Abstract

PROBLEM TO BE SOLVED: To take familiar slaked lime into the trachea without the need for clinical trials and approval applications requiring a considerable period and cost for nontuberculous mycobacteriosis, which is currently considered to be difficult to cure completely. It is an object of the present invention to provide a new therapeutic method capable of improving nontuberculous mycobacteriosis by the bactericidal effect of slaked lime. The present invention is an improvement method for improving non-tuberculous mycobacteriosis, in which powdery slaked lime is sent as a powder to either or both of the bronchi and lungs by a powder feeder. And the configuration using the pressurized suction device or the suction type suction device used in the improvement method was adopted. [Selection diagram] Fig. 1

Description

The present invention relates to a technique for improving nontuberculous mycobacteriosis, and more particularly to a therapeutic technique for improving nontuberculous mycobacteriosis by incorporating slaked lime into the lungs.

Nontuberculous mycobacteriosis was previously seen in many people with lung diseases such as tuberculosis, but in recent years, it has increased remarkably mainly in people without lung diseases, especially middle-aged and elderly women. It has increased about 6 times in the last 20 years, and it is said that 15,000 people have developed the disease in 2014. Therefore, this nontuberculous mycobacteriosis is no longer a rare disease and is expected to outnumber the death toll of tuberculosis in the future. The symptoms of nontuberculous mycobacteriosis are said to progress slowly over 10 years and have a long course that is difficult to cure completely. Currently, tuberculosis is treated with drugs, but for nontuberculous mycobacteriosis, the effects of the drugs are difficult to obtain, and the effects of the drugs have not been obtained. In other words, since it is often unclear in modern medicine, it is an extremely severe disease in which there is no choice but to face the symptoms and treat them so that they do not worsen, and the doctor says that it may be worse for the patient but not better. Most of the time you are told. Therefore, there is a demand for a therapeutic technique capable of curing such nontuberculous mycobacteriosis.

For the treatment of such nontuberculous mycobacteriosis, injections are used based on the administration of antibacterial agents (antibiotics). In the case of nontuberculous mycobacteriosis, if only one drug is taken for a long time, resistant bacteria will appear, the drug efficacy will be lost, and administration of multiple drugs will be required. In moderate or severe cases, one of the injectable drugs, streptomycin or kanamycin, must be injected intramuscularly for 2 months, and even if the symptoms subside, recurrence or reinfection will occur, so 2 years. I have to keep taking the medicine for 4 years. There is no drug that can completely cure nontuberculous mycobacteriosis, and the efficacy of the drug is not as good as that of tuberculosis, and once it develops, it is better to deal with it than to fix it.

Therefore, as a method for improving nontuberculous mycobacteriosis, there are means and methods for enhancing immunity in order to enhance natural healing power other than medication. For example, as a method of improving the intestinal environment and boosting immunity, spore-forming lactic acid bacteria can be delivered to the intestine to help the good bacteria in the intestine to predominate, or fermented foods and foods that pay attention to the diet. It is often necessary to keep in mind in daily eating habits so as not to weaken immunity by intestating a large amount of fiber. Therefore, it is urgent to establish an effective treatment method because it has a great influence on daily life.

Therefore, in view of the problem, various technical proposals have been made conventionally. For example, a technique in which the title of the invention is "peptide and its use" is disclosed (see Patent Document 1). Specifically, the subject was "providing a peptide capable of activating antigen-specific CD8-positive T cells derived from pathogenic microorganisms", and as a solution, "the 61st to 61st amino acid sequences of Ag85B protein of Mycobacterium kansashii". Activation of pluripotent CD8-positive T cells consisting of a peptide consisting of 9 to 50 amino acids including the 70th amino acid, or an amino acid sequence in which one or several amino acids are deleted, substituted or added in the peptide. A peptide having the ability. Further, an acidobacillosis peptide vaccine composition containing a peptide having the ability to activate CD4-positive T cells against acid bacteria. ”Has become a publicly known technique. However, the technique described in Patent Document 1 is a vaccine composition, which requires costly and time-consuming application for approval, and does not improve non-tuberculous mycobacteriosis by using familiar ones. , The technical means for solving the problem is different from the present invention.

Further, a technique is disclosed in which the title of the invention is "a drug that binds to a target of lung tissue for treating a respiratory disease" (see Patent Document 2). Specifically, "A drug that binds to a target in lung tissue (eg, antibody fragment, antagonist, ligand, dAb monodose) in the manufacture of a long-acting preparation or a long-acting therapeutic area preparation for local delivery to lung tissue. The use of the body) and methods for administering to the subject a drug that binds to a target in the lung tissue so that a sustained therapeutic range is achieved in the lung tissue. The formulation is for topical administration to the lung tissue. Also, the method comprises topical administration to lung tissue; further, the use of an antagonist of TNFR1 in the manufacture of formulations or pharmaceuticals for treating, preventing or suppressing lung inflammation or respiratory disease, as well as said. Also disclosed are methods of treating the disease. The use of said agents in the manufacture of delivery devices (eg, inhalers, intranasal delivery devices) for treating or preventing pulmonary inflammation or respiratory disease, as well as pulmonary inflammation or respiration. Disclose a delivery device containing the above-mentioned drug for treating or preventing a device disease. ”Has been published and has become a known technique. However, the technique described in Patent Document 2 is related to a drug like the technique of Patent Document 1, requires a costly and time-consuming application for approval, etc., and uses familiar ones to prevent non-tuberculosis. The technical means for solving the problem, which does not improve the acid mycobacteriosis, is different from the present invention.

Further, a technique is disclosed in which the title of the invention is "a method for predicting the pathological condition of non-tuberculosis antibacterial disease by VNTR type" (see Patent Document 3). Specifically, "to provide a method for predicting whether or not the patient's condition is progressive by examining the type of Mycobacterium avium avium detected at the time of diagnosis of nontuberculous mycobacteriosis." As a solution, the Manhattan distance was determined based on the number of repeated sequence polymorphisms in the genome between the control Mycobacterium avium strain and the Mycobacterium avium strain derived from patients with nontuberculous mycobacteriosis. A method of calculating and predicting the disease state of the patient by logistic regression analysis, an oligomer nucleotide primer set used in the method, and a PCR kit containing the oligomer nucleotide primer set. ”Has become a publicly known technique. There is. However, the technique described in Patent Document 3 is different from the present invention in that it relates to the direction of predicting the disease state and does not aim at eradicating nontuberculous mycobacteriosis.

As described above, nontuberculous mycobacteriosis is difficult to cure, but the following cases exist.
First, I would like to introduce such a case. About 10 years ago, I had coughing, sputum, tiredness, and shortness of breath. As a result of taking an X-ray photograph at the hospital, it was found that my lungs were getting worse due to nontuberculous mycobacteriosis. When I started taking the prescribed medicine, I had eczema all over my body, and I had it on my face. When I stopped taking the medicine because I couldn't tolerate it, the eczema disappeared and I felt better, so I didn't take the medicine for many years. The doctor told me that if I stopped taking the medicine, my illness would only get worse and not better. About two years ago, my body became sluggish and tired, and it became difficult to walk. When I went to the hospital and took an X-ray, my lungs were big and white, so I decided to take medicine again. However, cough, sputum, general malaise, low-grade fever, and weight loss occurred. Meanwhile, I was hit by a disaster caused by Typhoon No. 19 on October 12, 2019. When my house was flooded under the floor and slaked lime was sprayed under the floor and around the house for disinfection, I was very worried because I had to inhale the slaked lime a lot because I had no mask. However, in 2020, I did not have a cough or tiredness, and when I took an X-ray in January, my doctor told me that my lungs had improved. After that, he gained 4.5 kg and was told by the doctor that his roentgen results were improving in March and May. The only possible cause is the suction of slaked lime. Examples of such patients are female in gender and 83 years old (see FIGS. 2 and 3).

JP-A-2017-210427 Special Table 2009-512672 JP-A-2010-142150

The present invention eliminates the need for clinical trials and approval applications that require a considerable period of time and cost for nontuberculous mycobacteriosis, which is currently considered difficult to recover, and incorporates slaked lime that is familiar to the trachea. The challenge is to provide a new treatment method that can be improved.

The present invention is an improvement method for improving non-tuberculous mycobacteriosis, and adopts a configuration in which powdered slaked lime is sent as a powder to either or both of the bronchi and lungs by a powder feeder.

Further, in the present invention, the powder feeder used in the improvement method for improving the nontuberculous mycobacteriosis injects the powdery slaked lime into the oral cavity by the pressure of the compressed gas, and the bronchus. Alternatively, it may be a pressurized aspirator configured to send to either or both of the lungs.

Further, in the present invention, the powder feeder used in the improvement method for improving the non-tuberculous mycobacteriosis sucks the powdery slaked lime from the slaked lime container by the negative pressure of the flowing gas. It can also be a suction type aspirator configured to be injected into the oral cavity and sent to either or both of the bronchi and lungs.

According to the method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention, it has been said that the use of inexpensive slaked lime has no choice but to stop or worsen the progression of nontuberculous mycobacteriosis. It has an excellent effect of improving symptoms and making it possible to cure them.

In addition, the method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention exerts an excellent effect that slaked lime can reach the trachea in powder form by using a powder feeder.

Further, according to the method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention, the disinfecting effect of slaked lime is effective not only for nontuberculous mycobacteriosis but also for avian influenza infection control. Is considered to be.

It is a basic composition schematic explanatory diagram which shows typically the basic composition of the improvement method of the nontuberculous mycobacteriosis using slaked lime which concerns on this invention. It is a chest X-ray photograph at the time when improvement was observed by the improvement method of nontuberculous mycobacteriosis using slaked lime according to the present invention. It is a chest X-ray photograph showing the progress of improvement by the method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention. It is a basic principle explanatory drawing explaining the basic principle of the pressure type aspirator and the suction type aspirator used in the method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention.

The present invention is an improvement method for improving nontuberculous mycobacteriosis, and is characterized in that powdered slaked lime is sent as a powder to either or both of the bronchi and lungs. .. Hereinafter, description will be given based on the drawings. However, the shape and structure are not limited to those described in the drawings, and the changes can be made within the range in which the effect exerted as the creation of the technical idea of the present invention can be obtained.

FIG. 1 is a schematic explanatory diagram of a basic configuration schematically showing a basic configuration of a method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention.

The method 1 for improving nontuberculous mycobacteriosis using slaked lime is an improvement method for improving nontuberculous mycobacteriosis 10, and the powdery slaked lime 20 is left as a powder in the bronchi 30 or lung 40. The basic configuration is to send to either or both of. This will be described in detail below.

Nontuberculous mycobacteriosis 10 is sometimes pointed out by a chest X-ray examination as an abnormal shadow, and is said to be "an infectious disease, a member of Mycobacterium tuberculosis, but not transmitted to humans". A member of the tuberculosis bacterium, which is said to be different from tuberculosis, is a bacterium called nontuberculous mycobacteria, which is widely present in the natural environment such as soil, water, food, and animals (including livestock). Mycobacterium tuberculosis is a bacterium that parasitizes humans (the tuberculosis bacterium itself cannot survive in the environment) and is transmitted from person to person, but nontuberculous mycobacteria originally inhabit the familiar environment of humans such as soil and water. Therefore, it does not spread from person to person. Nontuberculous mycobacteriosis 10 caused by infection with this bacterium is considered to be a disease that has existed for a long time, but since it had symptoms and pathological conditions similar to tuberculosis, it was confused when there were many tuberculosis. Was being done. However, although it is similar to Mycobacterium tuberculosis, it was found to be a disease caused by another pathogen, and it has been called "atypical mycobacteriosis" for about 40 years. In recent years, the term "nontuberculous mycobacteriosis" has become common, and new nontuberculous mycobacteria have been discovered one after another, and the prevalence is increasing. Among them, the most common in Japan is called pulmonary MAC disease caused by Mycobacterium avium complexx, and it is said that this pulmonary MAC disease, which causes lesions mainly in the bronchi, has recently increased rapidly in women in Japan. As mentioned above, this pulmonary MAC disease is not an infectious disease unlike tuberculosis, but it is a type of nontuberculous mycobacteriosis 10 that is said to be difficult to respond to and can suppress its progression but does not improve. I'm sick.

The powdery slaked lime 20 is a powder of slaked lime (calcium hydroxide: Ca (OH) 2), which is generally used for adjusting the acidity of soil, and water is added to limestone mined all over the country. In addition, it is aged and powdered and is a strong base, but since it has not been designated as a deleterious substance, it is also used as a pH adjuster in reagents, agriculture, foods, and cosmetics. In addition, it is a material used in various situations such as a calcium supplement material, a chemically synthesized raw material, and a bactericide.

The bronchus 30 is an elongated air passage that extends from the pharynx to the lungs 40, with the bronchi having alveolar tips divided into left and right branches. Inflammation of the bronchi causes bronchitis, which causes respiratory symptoms such as cough and sputum, and asthma, which causes the bronchi to narrow due to allergies.

The lungs 40 take in oxygen from the air into the body and release carbon dioxide that is no longer needed. The air inhaled from the nose and mouth passes through the larynx and enters the trachea, and when the trachea enters the left and right lungs, it divides into two and becomes the bronchus 30. The bronchi are further subdivided, and beyond that are small bags of air called alveoli, which resemble a bunch of grapes. Further, since the lung 40 contains a large amount of air, the lung itself looks black even when a chest X-ray is taken. However, only that part of the lung that looks black when something happens to the lung 40 looks whitish, and the presence of these white parts is such as pulmonary tuberculosis, pulmonary mycosis, non-tuberculous mycobacteriosis, pneumonia, chronic tumors, etc. The possibility is suspected.

The oral cavity 60 is an empty space in the mouth, which is connected to the nasal cavity and pharynx, and serves as an entrance to the digestive tract to ingest, chew, and digest food, and also functions as a vocalizer and an auxiliary airway. This is the foremost part of sucking powdered slaked lime 20 in the method 1 for improving nontuberculous mycobacteriosis using slaked lime according to the present invention.

The compressed gas 50 is compressed air that is at atmospheric pressure or higher and is required to pressurize a certain amount of slaked lime and to convey the powdery slaked lime 20 at the joint portion 74 between the powder and the gas. In the pressurized suction device 2, it is necessary to provide pressure for pressurizing the powdery smelting lime 20 in the hopper 73 and injecting the powdery shaving lime 20 by the compressed gas 50 in the pressure vessel. In the suction type suction device, a large pressure is required because the powdery slaked lime 20 is sucked up from the generation of negative pressure due to the flow velocity.

The gas 51 to be circulated is a gas for sucking up powdered slaked lime 20 from the generation of negative pressure due to the flow velocity in the suction type suction device 3.

The pressure vessel 71 is a container for accommodating the compressed gas 50, and accommodates the gas necessary for injecting a fixed amount of slaked lime.

The hopper 73 is molded into a funnel shape provided at the bottom of the pressure vessel 71 containing the powdery slaked lime 20, and guides the powdery slaked lime 20 to fall.

The joint portion 74 between the powder and the gas is a portion where the powdery slaked lime 20 and the compressed gas 50 are mixed, and the slaked lime 20 of the solid fine particles is dispersed in the gas as a fluid so as to have a predetermined concentration. It is the part that creates the state.

The nozzle 75 is a discharge port for injecting the powdery slaked lime 20 into the compressed gas 50 made by the powder / gas mixing unit 54.

The powder feeder 70 is a general term for devices for supplying and discharging powders and granules, and may be a general powder aspirator or the like, and does not have to be a dedicated product. However, it has a function for administering an effective amount of powdered slaked lime to the trachea, and for example, the powdered slaked lime is cut out and transported from a storage tank or a hopper 73 according to the request of the process. In addition to maintaining continuous quantification and ensuring control responsiveness in consideration of the peculiar properties of powder, consideration is given to dust scattering prevention and safety by sealing.

The slaked lime collecting container 72 is a container for sucking up a predetermined amount of powdered slaked lime 20 by the gas 51 flowing when the powder feeder 70 is a horizontal suction device 3.

FIG. 2 is a chest X-ray photograph at the time when improvement was observed by the method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention. The patient in this roentgen photograph was at the time (January 24, 2020) when he felt that his symptoms were gradually alleviated, his cough decreased and he became less tired after inhaling slaked lime on October 12, 2019. is there. However, at this point, a large white shadow W (pneumonia image) can be seen as shown in FIG.

FIG. 3 is a chest X-ray photograph showing the progress of improvement by the method for improving non-tuberculous mycobacteriosis using slaked lime according to the present invention, and FIG. 3 (a) is a photograph showing the progress of improvement by the method for improving non-tuberculous mycobacteriosis. It is an X-ray photograph which took the chest of the non-tuberculous mycobacteriosis patient after the course, and FIG. 3 (b) is the X-ray photograph which took the chest of the same person patient two months later.

Further, FIG. 3 (a) was taken on March 5, 2020, and FIG. 3 (b) was taken on May 15, 2020. Comparing FIGS. 3 (a) and 3 (b) with FIG. 2, it can be clearly confirmed that the white shadow W in the roentgen photograph is lighter toward FIGS. 3 (a) and 3 (b). Unlike the cases of normal tuberculosis and pneumonia, the white shadow W once formed in the case of nontuberculous mycobacteriosis 10 does not disappear even by medication or the like. However, it is clear that the white shadow W is reduced, and the result shows that the nontuberculous mycobacteriosis 10 which has not been considered to be an effective treatment method has been improved. Is.

The white shadow W shows a pneumonia image of a patient with nontuberculous mycobacteriosis. Although it was not available, in the chest X-ray photograph before suction during the slaked lime spray disinfection performed for the inundation caused by typhoon No. 19 on October 12, 2019, there were more white shadows W than in Fig. 2. Was being done. That is, the symptom is alleviated after the suction of slaked lime, and then the symptom is improving.

FIG. 4 is an explanatory diagram of the basic principles for explaining the basic principles of the pressurized aspirator 2 and the suction type aspirator 3 used in the method 1 for improving non-tuberculous mycobacteriosis using slaked lime according to the present invention. 4 (a) shows the pressure suction device 2, and FIG. 4 (b) shows the suction type suction device 3 used in the method 1 for improving non-tuberculous mycobacteriosis using slaked lime according to the present invention. .. It should be noted that the embodiment shown in FIG. 4 is merely an example, and is not limited to such a configuration, and may be a powder feeder 70 that is common in principle. It should be noted that the one shown in the drawing is an example of the powder feeder 70, which is shown in a schematic manner, and the whole is made compact, and the valve mechanism and the pressure adjusting mechanism are omitted. The powder feeder 70 considered to be suitable in the method 1 for improving nontuberculous mycobacteriosis using slaked lime according to the present invention will be described below.

Conventionally, aerosols have been often used as powdered inhalants. However, since the use of chlorofluorocarbons used for spraying was banned, powder inhalants that do not use gas have been widely used. Since pharmaceutical powder alone adheres to and remains on instruments, many of them form secondary particles with an inert carrier such as lactose to reduce adhesion and make it easier to inhale. Currently, it is used for asthma treatment. It is used for corticosteroids. In many cases, a cassette-type dedicated inhaler is used in which tablets or capsules containing pharmaceutical powder are set and inhaled. Therefore, it is necessary to prevent the powdered slaked lime 20 used in the method 1 for improving non-tuberculous mycobacteriosis using slaked lime according to the present invention from adhering to and remaining on instruments and the like as in the case of these pharmaceutical powders. , It is preferable to form secondary particles with an inert carrier to reduce adhesion and facilitate inhalation.

The pressurized aspirator 2 is an aspirator used in the method 1 for improving non-tuberculous mycobacteriosis using slaked lime, and contains a certain amount of slaked lime and is compressed by a compressed gas. A powder feeder 70 for injecting slaked lime dropped by the gas 50 from the nozzle 75 to reach either or both of the bronchi 30 and the lungs 40. When such a configuration is adopted, injection is possible without requiring a very high compression pressure.

The suction type aspirator 3 is an aspirator used in the method 1 for improving non-tuberculous mycobacteriosis using slaked lime according to the present invention, and sucks slaked lime by the negative pressure generated by the flow of flowing gas to bronchi 30. , Or a powder feeder 70 for delivery to both lungs 40. If such a configuration is adopted, a high pressure is required, but a simple configuration can be used.

Further, although not shown in the drawing, a dry powder fixed-quantity inhaler that does not use the powder feeder 70 is also effective. The inhaler is a type of inhaler that inhales a powdered drug by oneself, and in the present invention, the user inhales a fixed amount of powdered slaked lime 20 by himself / herself.

The bactericidal effect of slaked lime will be described below. Slaked lime (calcium hydroxide) has been used for a long time and is a disinfectant with excellent cost performance, but it was difficult to prove its sterilizing power. Overcome the difficulty of experimenting with slaked lime (that is, it was difficult to obtain correct results because it was difficult to stop the alkali content after application to pathogenic microorganisms), and inside the slaked lime powder building that is often seen on farms. The following findings have been obtained from many experimental results, such as the effects of spraying on passages and using a step-on disinfection tank.

It was confirmed in this experiment that simply sprinkling slaked lime powder did not kill the pathogenic microorganisms on the surface and was ineffective against the pathogenic microorganisms that later flew over the lime. However, it is effective when it absorbs moisture due to humidity or dampness. That is, while it is wet, it becomes a strong alkali with a pH of around 12.5, so that the sterilizing effect is maintained.

It has been confirmed that putting only slaked lime powder in the disinfection tank has no effect, and a saturated solution with a pH of 12.5 or higher is effective, and even for a short time, it is effective against Salmonella (S. Typhimurium). In the method 1 for improving nontuberculous mycobacteriosis using slaked lime according to the present invention, it is considered that the powdered slaked lime 20 adheres to the mucous membrane of the trachea and the like, and the bactericidal effect is exhibited by the water content of the mucus.

In this way, when using slaked lime as a disinfectant, use one with a certain effect at an appropriate concentration, consider the effect on the human body and the degree of symptoms, etc., and adjust the pH and control the suction amount appropriately. There is a need to. In particular, when the pH is 12.5 or higher, sufficient caution is required because the alkalinity is high.

According to the method for improving nontuberculous mycobacteriosis using slaked lime according to the present invention, it is possible to improve the symptoms of nontuberculous mycobacteriosis, which was previously considered to be impossible to improve, and to cure the disease. Therefore, it is considered to have high industrial potential in the field of medical care for more than 15,000 patients annually.

1 slaked lime was the active ingredient to be nontuberculous slaked lime 30 bronchoalveolar 40 lung 50 compression improving agent 2 pressurized inhalator 3 intake have up type aspirator 10 nontuberculous mycobacterium diseases 20 powdery mycobacteriosis coupling portion 75 nozzles of the gas 60 oral 70 powder feeder 71 pressure vessel 72 slaked yield capacity container 73 hopper 74 powder and the gas being a gas 51 flows

Claims (3)

An improving agent that improves nontuberculous mycobacteriosis
With slaked lime as the active ingredient
The slaked lime (20) is non-tuberculous containing slaked lime as an active ingredient, which is powdered and sent to either or both of the bronchi and lungs in powder form by a powder feeder (70). An agent for improving mycobacteriosis. An aspirator for injecting the improving agent for nontuberculous mycobacteriosis containing slaked lime as an active ingredient according to claim 1 into the oral cavity to reach either or both of the bronchi and lungs.
A pressure vessel (71) in which a slaked lime container (72) containing the agent for improving non-tuberculous mycobacteriosis containing slaked lime as an active ingredient and a container containing a compressed gas (50) are integrally formed. In,
An agent for improving nontuberculous mycobacteriosis containing slaked lime as an active ingredient and a compressed gas (50) are contained therein.
Ejects from the hopper nozzle by the pressure of nontuberculous the compressed gas to improvers of mycobacteriosis as an active ingredient slaked lime according to claim 1 to fall through (73) (50) (75) A pressurized aspirator for a nontuberculous mycobacteriosis improving agent containing slaked lime as an active ingredient (2). An aspirator for injecting the improving agent for nontuberculous mycobacteriosis containing slaked lime as an active ingredient according to claim 1 into the oral cavity to reach either or both of the bronchi and lungs.
A slaked lime container (72) containing the agent for improving nontuberculous mycobacteriosis containing slaked lime as an active ingredient, and a slaked lime container (72).
Consists of a pressure vessel (71) containing a compressed gas (50)
Non-tuberculous with the slaked lime according to claim 1 as an active ingredient from the slaked lime containing container (72) due to the negative pressure generated from the gas (51) flowing from the pressure vessel (71) to the nozzle (75). A suction-type aspirator (3) for a non-tuberculous mycobacteriosis-improving agent containing slaked lime as an active ingredient, which is characterized in that an agent for improving mycobacteriosis is sucked up and sprayed from a nozzle (75).