JP6789036B2 - Automatic analyzer and laboratory information system - Google Patents

Description

The present invention relates to an automatic analyzer that analyzes a sample such as blood or urine in a clinical examination, and a laboratory information system that is a higher-level system for controlling the automatic analyzer.

Automatic analyzers that perform qualitative and quantitative analysis of biological samples such as blood and urine are becoming widespread mainly in many large-scale hospitals and testing centers due to the demand for speed and accuracy of analysis.

Further, in order to control these automatic analyzers, a laboratory information system (hereinafter referred to as LIS), which is a higher-level system of the automatic analyzers, has been introduced into the laboratory.

Conventionally, the automatic analyzer for which some inspection items cannot be analyzed generates an alarm and notifies the operating inspection engineer, but the operation state of the automatic analyzer continues until it is intentionally stopped. It is difficult to determine whether the device should be stopped immediately, and if the operation state is continued, a plurality of samples in which the test items that cannot be analyzed remain as untested will occur at random.

On the other hand, in Patent Document 1, when an abnormality occurs and a sample for which analysis cannot be performed or a sample for which reanalysis is required occurs, waiting for the completion of analysis of another sample erected in the rack is required. The sample that could not be analyzed or the sample that needed to be reanalyzed was displayed to the operating laboratory engineer by the identification information of the rack, and the sample that needed to be reanalyzed or for reanalysis. An automatic analyzer that identifies the sample to be collected, interrupts the analysis of the sample rack on which the sample is erected, provides a means to instruct the collection, and enables the collection and re-injection of the specific sample. It is presented.

International Publication No. 2010/122718

According to Patent Document 1, when an abnormality occurs and a sample that cannot be analyzed or a sample that needs to be re-analyzed occurs, the analysis of other samples erected in the rack is not completed. It is possible to collect the entire rack.

However, there is a problem that the rack on which the sample satisfying the setting condition according to the parameters registered in advance is erected always interrupts the analysis and performs the rack collection process, which is a semi-fixed operation.

In addition, the rack usually has a position for erection of multiple samples, and if an abnormality occurs in the middle position, a sample that can be processed normally and a sample that has not been processed because it was interrupted are mixedly loaded. There is also concern that it will be in a state. For this reason, there is still plenty of room for improvement.

The present invention has been made in view of the above, and the state changes of a plurality of automatic analyzers are sequentially transmitted from the automatic analyzers to LIS, and these are grasped and managed by LIS. Depending on the combination of whether or not the items of multiple automatic analyzers can be analyzed, it is possible to judge by LIS whether the automatic analyzer installed at the beginning should analyze as it is or whether it should be sent to another automatic analyzer, and the items that cannot be analyzed are It is possible to flexibly respond by processing the analysis item information to be transmitted to the partially generated automatic analyzer and encouraging it to be re-installed in another automatic analyzer without analyzing all the items. The purpose of this is to realize an automatic analyzer and LIS that can more appropriately support the operation of an operator such as an operating inspection engineer.

In the embodiment of the present invention for achieving the above object, a charging unit for loading a sample, a processing unit for processing the sample, a storage unit for storing the processed sample, the charging unit, the processing unit, and the processing unit. Communication between the LIS and the first operation unit in an automatic analyzer including a sample transfer line for transporting a sample between the storage units and a first operation unit that controls the input unit, the processing unit, and the storage unit. The first operation unit is an automatic analyzer that sequentially transmits the state information of the automatic analyzer to the LIS via the first communication means.

Further, in another aspect of the present invention, in the LIS, the analysis item of the sample rack loaded into the automatic analyzer is provided with an operation unit having a database for holding the device states of the plurality of automatic analyzers controlled by the LIS. , When replying as a response to an inquiry from the automatic analyzer to LIS, a function to determine whether some inspection items cannot be analyzed by the automatic analyzer, and all inspection items by other automatic analyzers. The calculation unit of the LIS is provided with a function of determining whether or not it is desirable to analyze all of the above.

Further, in another aspect of the present invention, in the content of returning the analysis item information to the automatic analyzer, "there is no item to be analyzed" or "analysis with another apparatus is recommended" for each sample rack. The LIS is provided with a function capable of setting information to the effect that the LIS is calculated.

In the automatic analyzer and LIS adopting the present invention, when an abnormality occurs in some inspection items of some automatic analyzers and analysis is not possible, the sample is put into another automatic analyzer together with the rack. The operation can be performed easily, reliably and efficiently.

It is a block diagram which shows the configuration example of an automatic analyzer. It is a block diagram which shows the structural example of LIS. It is a figure which represents a part of the database of LIS. It is a figure which shows the process which generates the analysis item information in the calculation part of LIS. It is a figure which shows the continuation process of FIG. It is a figure which shows an example of the parameter setting screen of LIS. It is a figure which shows that the judgment process by the parameter of FIG. 6 was added to a part of FIG. It is a figure which shows an example of the parameter setting screen of LIS. FIG. 7 is a diagram showing that the determination process based on the parameters of FIG. 8 is added. FIG. 5 is a diagram showing that a process for determining an updated flag in the process in FIG. 9 is added.

Embodiments of the present invention will be described below with reference to the drawings.

FIG. 1 is a block diagram showing the automatic analyzer 1.

The automatic analyzer 1 shown in FIG. 1 is an operation unit 16 (first operation unit) including a charging unit 11, a processing unit 12, a storage unit 13, and a communication means 15 (first communication means) for communicating with each device. A sample transport line 18 is provided, which transports the sample from the charging unit 11 to the processing unit 12 and the storage unit 13, and transports the sample so as to return the sample from the storage unit 13 to the charging unit 11 and the processing unit 12.

The loading unit 11 is a portion for loading the sample rack 314 (hereinafter, also referred to as rack 314) on which the sample container 313 containing the sample is erected into the automatic analyzer 1, and has the sample scanner 11a. .. The sample scanner 11a is a device that reads the sample barcode attached to the sample container 313 loaded from the charging unit 11 and recognizes the identifier of the rack 314 that houses the sample container 313, and which sample container 313 is which rack. It is used to identify whether it is erected at the position inside 314.

The processing unit 12 is a part for processing a sample, that is, a part for analyzing the concentration of biological components contained in the sample. The processing unit 12 includes a reaction vessel 301, a reaction disk mechanism 302, a constant temperature bath 303, and the like. Reagent storage section 304, sample dispensing mechanism 305, reagent dispensing mechanism 306, stirring mechanism 307, cleaning mechanism 308, light source 309, photometer 310, A / D (Analog / Digital) converter 311 Has.

The reaction vessel 301 is a vessel in which a reagent and a sample are put and reacted.

The reaction disk mechanism 302 is a member that holds a plurality of reaction vessels 301. Further, the reaction disk mechanism 302 conveys the reaction vessel 301 installed in itself to a designated position.

The constant temperature bath 303 is a mechanism for keeping the reaction vessel 301 installed in the reaction disk mechanism 302 at a predetermined temperature, and keeps the reaction vessel 301 at a predetermined temperature.

The reagent storage unit 304 is a member that holds a plurality of reagent bottles 312, which are containers for accommodating reagents used for analysis. In addition, the reagent storage unit 304 conveys the reagent bottle 312 installed in itself to a designated position.

The sample dispensing mechanism 305 is equipped with a sample dispensing probe, and is a device that divides a sample into small amounts of a fixed amount. The sample dispensing mechanism 305 dispenses a predetermined amount of the sample in the sample container 313 into the reaction container 301.

The reagent dispensing mechanism 306 is a device including a reagent dispensing probe, which divides a reagent into small amounts of a fixed amount. The reagent dispensing mechanism 306 dispenses a predetermined amount of the reagent contained in the reagent bottle 312 into the reaction vessel 301.

The stirring mechanism 307 is a device that stirs the solution of the reagent and the sample contained in the reaction vessel 301 to make the distribution state of the components uniform.

The cleaning mechanism 308 is a device that sucks the waste liquid and discharges the cleaning liquid. The washing mechanism 308 sucks the solution of the reagent and the sample contained in the reaction vessel 301. Further, the cleaning mechanism 308 cleans the reaction vessel 301 by discharging the cleaning liquid into the reaction vessel 301.

The light source 309 is a portion that emits light used for measuring the absorbance, and is composed of a halogen lamp or the like.

The photometer 310 is a portion that is emitted by a light source 309, receives light that has passed through the reaction vessel 301, and measures the absorbance of the solution in the reaction vessel 301, and is composed of a spectrophotometer or the like. The photometer 310 transmits the absorbance information to the A / D converter 311.

The A / D converter 311 is a device that converts an analog signal into a digital signal, and after converting the input analog signal into a digital signal, records it in the database 17.

The storage unit 13 is a portion for storing the processed sample, that is, the rack 314.

The communication means 15 is a member such as a cable or a radio for mutual communication of each mechanism in the automatic analyzer 1. Further, the communication means 15 communicates between the LIS 2 and the operation unit 16.

The operation unit 16 links information with the LIS 2 via the communication means 15, exchanges analysis item information, analysis results, and the state of the automatic analyzer, updates the contents of the database 17, and displays the contents on the monitor 14. Is displayed, and the speaker 19 is sounded if necessary. The operation unit 16 also controls the charging unit 11, the processing unit 12, and the storage unit 13. Further, the operation unit 16 sequentially transmits the state information of the automatic analyzer 1 to the LIS 2 via the communication means 15.

FIG. 2 is a block diagram showing LIS2.

The operation unit 116 (second operation unit) of the LIS 2 shown in FIG. 2 links information with a plurality of automatic analyzers 1 by the communication means 115 (second communication means), updates the contents of the database 117, and monitors. The content is displayed on 114, and the speaker 119 is sounded if necessary.

The communication means 115 communicates with a plurality of automatic analyzers controlled by LIS 2 and the operation unit 116.

That is, the operation unit 116 sequentially receives the state information of each automatic analyzer 1 sequentially transmitted from the plurality of automatic analyzers 1 via the communication means 115, sequentially stores the state information in the database 117, and stores the state information in the database 117. The state information of each automatic analyzer 1 is sequentially updated. The typical state information is the analysis availability status information for each analysis item for each automatic analyzer for creating the inspection item status table 203 of FIG.

In addition to the case where a specific analysis item cannot be analyzed in advance on the automatic analyzer side by updating the sequential state information, the analysis item that was initially able to be analyzed is the analysis item during the operation state due to reasons such as lack of reagents. Even if the availability is changed, it is possible to quickly operate the device in response to the state change, and for example, it is possible to avoid a situation in which some uninspected items remain for each rack.

The calculation unit 120 generates analysis item information by referring to the contents of the database 117 according to the instruction from the operation unit 116, and returns the information to the operation unit 116. That is, the calculation unit 120 generates analysis item information for determining which item each automatic analyzer 1 analyzes for a specific rack 314.

The automatic analyzer 1 of FIG. 2 shows that it has the same components as those of FIG. 1, and the detailed components are omitted and illustrated.

FIG. 2 shows, as an example, a mode in which one LIS2 controls three automatic analyzers 1. However, the number of components of the automatic analyzer 1 and the presence / absence of their connection can be freely combined depending on the operation format of the laboratory.

FIG. 3 is an example of tabular data showing some details of the LIS2 database 117.

In the LIS2 database 117, the operating status (whether or not it can be used) of each of the plurality of automatic analyzers 1 controlled by LIS2 based on the information related to the patient sample and the information received via the communication means 115. ), And the analysisable item status (analyzable status information) is recorded.

The operation status table 201 holds the operation status 202 for each automatic analyzer 1 controlled by LIS2. In an example of FIG. 3, the automatic analyzer 1 (device number 3) whose operating status is other than “0” represents a state in which it is not operating or is not operating due to maintenance such as cleaning or parts replacement. The automatic analyzer 1 whose status is "0" indicates that it is in operation (device numbers 1 and 2).

The inspection item status table 203 holds the analysis availability status 204 (analysis availability status information) for each inspection item that can be analyzed by the automatic analyzer 1 controlled by LIS2. In one example of FIG. 3, it is shown that the inspection item whose analysis availability status is "0" can be analyzed, and the inspection item whose analysis availability status is "other than 0" cannot be analyzed.

4 and 5 are diagrams showing a flowchart for realizing a process of generating analysis item information in the calculation unit 120 of LIS2.

The calculation unit 120 of LIS2, which has received the analysis item inquiry from the automatic analyzer 1 via the operation unit 116, first starts processing (step S30).

Here, the operation unit 116 receives an inquiry about an analysis item to be analyzed by the automatic analyzer for a specific rack to be analyzed by the automatic analyzer 1. The analysis item for which a specific rack or a specific sample is scheduled to be analyzed is stored in the database 117. For example, the operation unit 15 can read an identifier such as a barcode of the rack or the sample container with the sample scanner 11a. Make an inquiry to 116.

Next, the calculation unit 120 starts a repeat process (first loop) for the number of samples (maximum number of positions) in rack units inquired by the automatic analyzer 1 (step S31).

Next, the calculation unit 120 initializes the analysis item information (for the device) of the position sample and the analysis impossible flag (for all the devices) (steps S32 and S33).

Next, the calculation unit 120 starts the repeat process (second loop) for the number of requested items of the position sample (step S34).

The circle A will be described later.

Next, the calculation unit 120 collates the inspection item status table 203 updated based on the information transmitted from the sequentially automatic analyzer 1, and determines whether the item can be analyzed by the apparatus (step S35). When it is determined that the analysis is possible, the process proceeds to step S41, and when it is determined that the analysis is impossible, the process proceeds to step S36.

The calculation unit 120 that has moved to step S36 switches on the non-analyzable flag of the device of the position sample, and then the calculation unit 120 starts the repeat processing (third loop) for the number of devices other than the device. (Step S37).

Next, the calculation unit 120 determines whether the item can be analyzed by another device (step S38). When it is determined that the analysis is possible, the process proceeds to step S40, and when it is determined that the analysis is impossible, the process proceeds to step S39.

The calculation unit 120 that has moved to step S39 turns on the non-analyzable flag of the position sample / other device.

Step S40 represents the end position of the third loop, and the process proceeds to step S41 after the repetition process is completed.

Next, the calculation unit 120 adds the item to the analysis item information of the position sample (step S41). The reason why the item is also added to the analysis item information even though it is once determined that the device cannot analyze in step S35 is that the calculation unit 120 of LIS2 generates the analysis item information and then goes to the automatic analysis device 1. This is because the possibility that the item has also transitioned to an analyzable state due to the treatment on the automatic analyzer 1 side during this period is taken into consideration.

Step S42 and step S43 represent the end positions of the second loop and the first loop, and the processes are repeatedly executed, respectively.

The circle B will be described later.

The circle C represents the continuous position of FIGS. 4 and 5.

Next, the calculation unit 120 determines whether the analysis flag of the device is on (step S44). When it is determined to be on, the process proceeds to step S45, and when it is determined to be other than on (hereinafter referred to as off), the process proceeds to step 51.

The calculation unit 120 that has moved to step S45 starts the repeat processing (fourth loop) for the number of other devices other than the device.

Next, the calculation unit 120 determines whether the analysis impossible flag of the other device is on (step S46). When it is determined to be on, the process proceeds to step S47, and when it is determined to be off, the process proceeds to step S48.

Step S47 represents the end position of the fourth loop, and the process proceeds to step S51 after the repetition process is completed.

The calculation unit 120, which has moved to step S48, exits the fourth loop and determines whether the other device can receive the information "recommending analysis by another device". When it is determined that reception is possible, the process proceeds to step S49, and when it is determined that reception is not possible, the process proceeds to step S50.

The calculation unit 120 that has moved to step S49 sets information to the effect that “analysis by another device is recommended” instead of the analysis item information of the rack, and moves to step S51.

The calculation unit 120 that has moved to step S50 initializes the analysis item information of all the samples in the rack, puts it in a state of “no item to be analyzed”, and moves to step S51.

The calculation unit 120 that has moved to step S51 transmits the generated analysis item information to LIS2 via the operation unit 116, and ends a series of processes.

Due to these processing flows shown in FIGS. 4 and 5, in the operation using the erection container using the rack 314 of one rack and multiple positions, there is no request for the non-analyzable item for all the position samples, and the automatic analyzer 1 also has a problem. If the analysis can be performed without any problem, the analysis item information is set as usual so that the operation state of the automatic analyzer 1 is not continuously reduced in efficiency.

On the contrary, when there is a request for an item that cannot be analyzed for a sample in a certain position, the analysis item information is initialized so that all the position samples are not analyzed, and the analysis item information is set to "no item to be analyzed" and the automatic operation is performed. It is transmitted to the analyzer 1 to realize early rack collection.

In this way, the calculation unit 120 generates the analysis item information based on the analysis schedule item information and the analysis availability status information for the sample rack stored in the database 117. The calculation unit 120 does not simply generate the item information to be analyzed as the analysis item information, but adds the analysis availability status information.

For example, when the arithmetic unit 120 analyzes a specific rack 314 with the automatic analyzer 1 inquired based on each analysis availability status information of each automatic analyzer, whether or not some uninspected items remain. Then, it is determined whether or not it is desirable to analyze with another automatic analyzer 1 controlled by LIS2 instead of the automatic analyzer 1 inquired. Then, when the calculation unit 120 determines that it is desirable to analyze the specific rack 314 with the other automatic analyzer 1, the calculation unit 120 initializes the item information of the analysis schedule for the specific rack 314 and automatically receives an inquiry. The initialized information is transmitted to the analyzer 1.

Further, when the arithmetic unit 120 determines that it is desirable to analyze a specific rack 314 with another automatic analyzer, the automatic analyzer inquired "recommends analysis with another device". It is also possible to determine whether the information can be received, and in the case of an automatic analyzer that can receive the information, generate information to the effect that "analysis with another device is recommended" instead of the analysis item information. In the implementation, it is desirable to be able to select whether or not to set the information "recommend analysis with other devices" instead of the analysis item information as an option treatment.

Based on the analysis item information from LIS2, the rack 314 that does not analyze all the position samples in the automatic analyzer 1 and collects them in the storage unit 13 is different from the rack 314 on which the samples that have been analyzed are erected as usual. It is desirable that the operator (testing engineer) can easily understand that the sample group has a mechanism to be collected in a place and should be analyzed by another device. That is, the storage unit 13 has a collection position different from that of the rack 314 where the normal analysis has been completed, and the operation unit 16 receives the initialized information or "recommends analysis with another device". When the information to the effect is received, it is desirable to transport the information to the collection position without analyzing it by the automatic analyzer 1 that has been inquired regardless of the item information to be analyzed.

Upon receiving the information from LIS2 that "analysis with another device is recommended", the operation unit 16 of the automatic analyzer 1 generates an alarm on the monitor 14 or the speaker 19, and the rack 314 or the sample is displayed on the monitor 14. It is desirable to implement an implementation that notifies the operator that "analysis with other equipment is recommended" by highlighting the position.

So far, we have described how to realize an operation in which uninspected items do not remain, but on the other hand, priorities are set for each inspection item, and items with low priority and analysis results that are not urgent are left uninspected. It is also possible to assume the operation that it does not matter.

As an example for supporting this operation, FIG. 6 shows an example of a parameter screen of LIS2 for registering the priority for each inspection item.

FIG. 7 is a diagram showing that a determination process (step S61) based on the parameters of FIG. 6 is added between a part of FIG. 4, that is, the circles A and B described above.

In step S61, the calculation unit 120 determines whether or not the priority of the item is “low”. When it is determined to be "low", the process proceeds to step S41 without performing all the subsequent processes. If it is determined to be other than "low", the process proceeds to step S36.

Due to these processing flows shown in FIGS. 4, 5 and 7, even if some position samples are requested for non-analyzable items and cannot be analyzed by the automatic analyzer 1, the priority is low. If only the inspection item cannot be analyzed, the analysis item information can be used as usual and analyzed by the automatic analyzer 1 as it is. These items will remain uninspected on the device, depending on the operation desired by the operating operator.

In addition to the priority of each test item, the attributes of the sample (requester, doctor in charge, disease name, etc.) are used to determine whether or not to leave untested as in the judgment process (step S61) of FIG. It can also be carved. The analysis item information generation process for leaving untested using the attributes of the sample can be determined and processed in the same manner as the item priority treatment shown in FIG. 7, and is not shown.

In this way, the priority for each test item or the attribute of the sample is stored in the database 117, and the calculation unit 120 receives an inquiry based on the analysis availability status information of the inquired automatic analyzer. When the rack 314 is analyzed with, it is determined whether or not some untested items remain, and the calculation unit 120 determines the priority of each test item stored in the database 117 or the attribute of the sample. If it is acceptable that some uninspected items remain, it is desirable to generate the item information to be analyzed as the analysis item information and send it to the automatic analyzer that made the inquiry. By registering each item in the database 117 in advance as shown in FIG. 6, the calculation unit 120 can tolerate the situation where uninspected items remain, or the items to be analyzed without being allowed. Determine if you want to initialize the information.

By the way, in the automatic analyzer 1, analysis results are due to physical factors such as shortage and deterioration of consumables such as reagents and diluents, and poor insulation and deterioration of electrodes for analyzing electrolyte concentration. Can not be output.

On the other hand, in addition to these, it is possible to obtain analysis results such as avoiding carryover with water due to lack of detergent and performing calibration with expired reagents, but if there is concern about the credibility of the results, it is also operational. Exists.

The factors of "physical" and "credibility anxiety" are shared and distinguished by the automatic analyzer 1 and LIS2, and the device state of transmitting from the automatic analyzer 1 to LIS2 is also distinguished and transmitted and received. Can be assumed.

As an example for supporting this operation, the meaning of "analyzable / unanalyzable status" in the inspection item information table shown in FIG. 3 is expanded, and for example, "0 = analyzable" and "1 = unanalyzable (physical)". ) ”,“ 2 = Unanalyzable (credibility anxiety) ”,“ 3 = Unanalyzable (Other) ”, etc., and parameters are provided on the LIS2 side as shown in FIG.

FIG. 9 shows an example in which determination processing (steps S62 and S63) of the calculation unit 120 of LIS2 according to the parameter shown in FIG. 8 is added to the processing flow of FIG. 7.

In step S62, the calculation unit 120 determines whether or not the factor that the item cannot be analyzed is a physical one. When it is determined that it is physical, if "processing condition = uninspected" is set in the parameter shown in FIG. 8, the process proceeds to step S65. When it is determined that the device is physical, if the parameter shown in FIG. 8 is set to "processing condition = other device", the process proceeds to step S64. If it is determined that it is not physical, the process proceeds to step S63.

Next, in S63, the calculation unit 120 determines whether or not there is a factor that causes anxiety in the credibility of the result of the item. When it is determined that the credibility is uncertain, if "processing condition = uninspected" is set in the parameter shown in FIG. 8, the process proceeds to step S65. When it is determined that the credibility is uncertain, if "processing condition = other device" is set in the parameter shown in FIG. 8, the process proceeds to step S64. When it is determined that there is no concern about the credibility, the process proceeds to step S36.

The calculation unit 120 that has moved to step S64 turns on the other device recommended flag of the position sample. Although not shown, the flag needs to be initialized at the latest just before entering the second loop.

The calculation unit 120 that has moved to step S65 redetermines whether or not the factor that the item cannot be analyzed is a physical one. If it is determined to be physical, the process proceeds to step S41. When it is determined that it is not physical, it shifts to the front of the circle B, that is, the end position of the second loop.

The significance of this step S65 is that although the credibility of the analysis result is uncertain, the result is output. Therefore, when the item is added to the analysis item information to the device, it is inspected in the same manner as the normal item. , It is considered to avoid being confused as it is. By not adding the item to the analysis item information to the device, the untested item on the device does not occur, but it remains untested on LIS2, and the credibility is uncertain outside the laboratory such as clinical practice. It is possible not to report some analysis results.

However, it is appropriate that the concept of step S65 can be selected according to the operation desired by the operating operator. That is, since it is possible to analyze with the device and report to the clinic at the operator's discretion, or to stop and re-examine with another device, it is optional that step S65 always defeats the judgment on the "Yes" side. Can be adopted as a treatment.

The state information includes the presence / absence of factors that cannot physically analyze the items and the presence / absence of factors that cause anxiety about the credibility of the analysis results. The operation unit 16 determines the presence / absence of these factors in LIS2 that controls the automatic analyzer. Is desirable.

Further, the operation unit 116 receives as state information whether or not there is a factor that cannot physically analyze the item and whether or not there is a factor that causes anxiety about the credibility of the analysis result, and determines whether or not to analyze each factor in advance. The table is stored in the database 117, and when there is any one of the factors, the calculation unit 120 processes the item information to be analyzed based on the table, generates it as the analysis item information, and makes an inquiry. It is desirable to send to the automatic analyzer that had.

FIG. 10 shows an example in which the determination process (step S66) of the other device recommended flag of the position sample is added to FIG.

In step S66, the calculation unit 120 determines whether the other device recommended flag is on. When it is determined to be on, the process proceeds to step S49. When it is determined to be off, the process proceeds to step S48.

With these added judgment processes, it is possible to flexibly take the system operation desired by the operating operator.

In this example, multiple "physical" factors and "credibility anxiety" factors are grouped together, but the degree of subdivision, distinction, and control of these factors should be considered in implementation. It should be.

So far, we have described physical factors and the credibility of analysis results, but the operator intentionally stops the analysis of some inspection items (hereinafter referred to as intentional item mask). There is. Intentional item mask refers to the fact that the operator himself / herself knows that it is not desirable to continue the analysis as it is, such as deterioration of reagents or expiration of reagents, and in a sense. , It can also be called "degenerate operation" for each item.

Such an intentional item mask is performed by the operator's intention, and the operating operator naturally knows that the inspection item of the automatic analyzer 1 is not inspected. Therefore, the behavior of not analyzing all the samples in the rack 314 on which the samples including the intentionally masked items are erected may be rather confusing to the operator.

Therefore, it can be assumed that the intentionally masked items are not urgent as described in the handling of item priority, and may be left uninspected. The analysis item information generation process for leaving the intentional mask item uninspected can be determined and processed in the same manner as the item priority treatment shown in FIG. 7, and is not shown.

On the other hand, as a function of the automatic analyzer 1, there is an operation of automatically masking an inspection item satisfying a certain condition (hereinafter, referred to as an apparatus recommended mask).

Such a device recommended mask is automatically applied and at the same time an alarm or the like is generated, but it is not always transmitted to the operator who operates the mask.

Therefore, the device recommended mask is not treated the same as the intentional item mask, and it is possible to implement individual judgment processing and analyze everything with another device or leave some as uninspected with the device. It should be implemented so that the operator can choose.

As described above, the determination process related to the device recommended mask can also be dealt with by adding the parameter and the determination process to the transmission / reception interface of the automatic analyzer 1 and LIS2, and LIS2, so that the specific illustration is omitted.

By implementing these functions, it is possible to automatically process whether it is desirable to analyze all test items at once with any of the multiple automatic analyzers that exist in units of racks on which samples are erected. Therefore, it is possible to reduce the judgment and manual work of the operator to operate, and it is expected that the work efficiency will be improved.

Further, in the above-described embodiment, an automatic analyzer that performs biochemical analysis of blood or the like has been described as an example as an automatic analyzer, but the automatic analyzer is not limited to the biochemical analyzer and is immunological analysis. It can also be applied to an immunoassay device that analyzes both biochemistry and immunology in an integrated manner.

From the above examples, the following effects can be obtained.

In the operation of batch processing a large number of samples with multiple automatic analyzers, when an abnormality occurs in some test items of some automatic analyzers and analysis is not possible, the sample is sent to another automatic analyzer for each rack. It is possible to easily and surely and efficiently perform the operation of reintroducing.

1 ... Automatic analyzer, 2 ... LIS, 11 ... Input section, 12 ... Processing section, 13 ... Storage section, 14.114 ... Monitor, 15/115 ... Communication Means, 16.116 ... Operation unit, 17.117 ... Database, 18 ... Sample transfer line, 19 ... Speaker, 120 ... Calculation unit, 30 ... Analysis item information generation processing, 201 ... Operation status table, 202 ... Operation status table registration contents, 203 ... Inspection item status table, 204 ... Inspection item status table registration contents, 211 ... Inspection item parameter screen, 212 ... -Inspection item parameter setting contents, 221 ... Analysis condition setting parameter screen, 222 ... Analysis condition setting parameter setting contents, 301 ... Reaction vessel, 302 ... Reaction disk mechanism, 303 ... Constant temperature bath, 304 ... Reagent storage, 305 ... Specimen dispensing mechanism, 306 ... Reagent dispensing mechanism, 307 ... Stirring mechanism, 308 ... Cleaning mechanism, 309 ... Light source, 310 ... Photometer, 311 ... A / D converter, 312 ... Reagent bottle, 313 ... Sample container, 314 ... Rack

Claims (11)

A sample transport line that transports a sample between a loading section for loading a sample, a processing section for processing the sample, a storage section for storing the processed sample, and the loading section, the processing section, and the storage section. When the insertion portion, the processing unit, and a first operating unit for controlling the storage unit, the laboratory information system for controlling a plurality of automatic analyzers comprising,
The automatic analyzer
Comprising a first a communication vehicle for communicating with laboratory information system and the first operating unit,
The first operation unit sequentially transmits the state information of the automatic analyzer to the laboratory information system via the first communication means .
The laboratory information system
A second operation unit, a second communication means for communicating with the plurality of automatic analyzers and the second operation unit, and a calculation unit are provided.
The second operation unit is
Upon receiving the analysis availability status information regarding the analysis availability status of each automatic analyzer transmitted from the plurality of automatic analyzers,
The calculation unit
When an inquiry is received regarding an analysis item in a specific sample rack to be analyzed by one of the plurality of automatic analyzers, the one is based on the received analysis availability information of each automatic analyzer. Of the automatic analyzers of the above or other controlled automatic analyzers, the automatic analyzer suitable for the analysis of the specific sample rack is determined.
When it is determined that the other automatic analyzer is suitable for analysis instead of the one automatic analyzer, the analysis item information to be analyzed in the specific sample rack is initialized, and the initialized information is used as the one. Laboratory information system characterized by sending to an automated analyzer. In test査室information system of claim 1,
Receiving said second operation section is provided with a database that analyzes whether status information of the automatic analyzer is stored to be transmitted from a plurality of analyzers,
It said second operating unit, laboratory information system, characterized in that, characterized in that to update the analysis whether status information of the automatic analyzer is stored in the database. In the laboratory information system of claim 2,
The plurality of analyzers sequentially transmit analysis availability status information of each automatic analyzer to the second operation unit via the second communication means.
The second operation unit is a laboratory information system characterized in that it sequentially receives the analysis availability status information that is sequentially transmitted, and sequentially updates the storage and update in the database . In the laboratory information system of claim 1 ,
The calculation unit
When the inquiry is received, some untested items remain when the specific sample rack is analyzed by the one automatic analyzer that received the inquiry based on the analysis availability information of each received automatic analyzer. A laboratory information system characterized by determining whether or not it is . In the laboratory information system of claim 1 ,
The calculation unit
If it is determined that the one of the other of the automatic analyzer not automatic analyzer is suitable for analysis, one automatic analyzer had the query is recommended analysis in the other automatic analyzer and determine possible receive information indicating that, if possible receive the laboratory information system, characterized in that for generating the effect of information relevant recommendations. In the automatic analyzer controlled by the laboratory information system of claim 1 ,
Further, the storage unit is provided with a collection position different from the position where the sample rack for which normal analysis has been completed is stored .
Said first operating unit, as a result of a query about the analysis items in a particular sample rack that will be analyzed, when receiving the information initialized by the arithmetic unit, regardless of the analysis item of the analysis plan , an automatic analyzer, characterized in that conveying the specific sample rack, without analyzing the recovery position. In the automatic analyzer controlled by the laboratory information system of claim 5.
Further, the storage unit is provided with a collection position different from the position where the sample rack for which normal analysis has been completed is stored .
When the first operation unit receives information to the effect that analysis with the other automatic analyzer is recommended as a result of inquiring about the analysis item in the specific sample rack to be analyzed, the analysis schedule is scheduled. automatic analyzer, wherein the specific sample rack regardless analysis items to be conveyed to the recovery position. In the automatic analyzer controlled by the laboratory information system of claim 5.
Equipped with a display
When the first operation unit receives inquiries regarding analysis items in a specific sample rack to be analyzed and receives information to recommend analysis with the other automatic analyzer, the first operation unit receives information .
Automatic analyzer according to claim Rukoto shown Table on the display unit the position of the specimen before Symbol particular sample rack or the sample rack. In the laboratory information system of claim 1,
It has a database that stores the priority of each analysis item or the attributes of the sample .
The calculation unit
When receiving the inquiry, and the received, based on the amount析可whether status information of the automatic analyzer was the inquiry is, in the automatic analyzer had the inquiry Analysis of the specific sample rack, some untested Judge whether or not the item remains ,
Priority for each of the analysis section stored in the database, or, based on the attribute of the specimen, if it can tolerate a situation where the items of part unchecked remain, the partial析項th information item information of the analysis plan A laboratory information system characterized in that the inquiry is generated as an automatic analyzer and transmitted to the automatic analyzer. In the automatic analyzer controlled by the laboratory information system of claim 1.
The analysis availability status information includes the presence or absence of factors that cannot physically analyze the item , and the presence or absence of factors that cause anxiety about the credibility of the analysis results.
Said first operating unit, an automatic analyzer and transmits the presence or absence of these factors before dangerous査室information system. In the laboratory information system of claim 9, which controls the automatic analyzer of claim 10.
It said second operation unit receives the presence or absence of factors which can not analyze the physical item, and the presence or absence of factors which are concerned about the authenticity of the analysis result as the analysis whether status information,
A table in which it is determined in advance whether or not to analyze each of the factors is stored in the database.
When there is any one of the above factors, the calculation unit processes the item information to be analyzed based on the table, generates it as the analysis item information, and automatically receives the inquiry. A laboratory information system characterized by sending to an analyzer.

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