JP6774767B2 - Topical skin composition - Google Patents

Description

The present invention maintains the stability of vanillyl alkyl ether and maintains the stability of vanillyl alkyl ether even in a skin external preparation composition capable of providing a good feeling of warmth, particularly in an aqueous system containing a large amount of water. , With respect to a skin external preparation composition capable of providing a good feeling of warmth.

Conventionally, the external preparation composition for skin may contain a component that gives a warm feeling when applied to the skin, and as a substance that gives a warm feeling, benzyl nicotinate, capsicum extract, vanillyl amide nonylate, and the like are used. Are known. However, although these have a strong feeling of warmth, they have drawbacks such as causing skin irritation when the blending amount is increased. On the other hand, vanillyl alkyl ether is known to be mild and provide a good feeling of warmth (Patent Document 1). However, when preparing an aqueous external preparation, the stability of vanillyl alkyl ether over time cannot be obtained depending on the mixing ratio of polyhydric alcohol and ethanol with water and the type of polyhydric alcohol, and the temperature is particularly high. Under storage, the decrease in stability becomes remarkable. Under these circumstances, for example, Patent Document 2 maintains the stability of vanillyl butyl ether by controlling the blending ratio of vanillyl butyl ether, a specific polyhydric alcohol, ethanol, and water.
However, in the preparations prepared in these ratios, more than 40% of water cannot be blended, and it is not possible to obtain a water-based external preparation that satisfies the feeling of use. Therefore, even if a large amount of water is blended, vanillyl A preparation capable of stably holding the lylalkyl ether has been desired.

Japanese Unexamined Patent Publication No. 2003-95842 Japanese Unexamined Patent Publication No. 2014-70063

The present invention provides a preparation capable of stably storing vanillyl alkyl ether. Further, the present invention provides a skin external preparation composition that can enhance the relaxing effect of the user by providing a warm feeling to the body when applied to the body, and thus can reduce the stiffness of the body such as shoulders and neck.

As a result of intensive studies to achieve the above object, the present inventors have selected vanillyl alkyl ether as a warming component from polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene sorbit fatty acid ester. By blending one or more kinds of surfactants, the stability of vanillyl alkyl ether is maintained, and the warming effect of vanillyl alkyl ether is provided to the body, which gives an excellent feeling of relaxation and shoulders and neck. It was found that a reduction in stiffness can be obtained. Specifically, the present invention may relate to the following aspects.

[1]
One or more surfactants selected from (a) vanillyl alkyl ethers and (b) polyoxyethylene polyoxypropylene alkyl ethers and polyoxyethylene sorbitol fatty acid esters.
An external preparation composition for skin, which comprises.
[2] The skin external preparation composition according to the above [1], wherein the mass ratio of the component (b) to the component (a) is 1/10 to 100/1.
[3] The skin external preparation composition according to the above [1] or [2], which further contains 40% by mass or more of water with respect to the mass of the skin external preparation composition.
[4] The skin external preparation composition according to any one of the above [1] to [3], wherein the component (a) is selected from vanillyl butyl ether, vanillyl propyl ether, and vanillyl pentyl ether. ..
[5] The external application for skin according to any one of [1] to [4] above, further containing a cooling sensation-imparting component selected from menthol, l-menthylglyceryl ether, and ethanol as the component (c). Agent composition.
[6] The skin external preparation composition according to any one of the above [1] to [5], further containing cis-3-hexene-1-ol as a stress-reducing component as the component (d).
[7] The skin external preparation composition according to any one of [1] to [6] above, wherein the HLB of the component (b) is 10.5 or less.
[8] The external preparation composition for skin according to any one of [1] to [7] above, which is a coating agent or a patch.
[9] An external preparation for reducing body stiffness by imparting a feeling of warmth, which contains the skin external preparation composition according to any one of the above [1] to [8].
[10] A stabilizer for vanillyl alkyl ether, which contains one or more surfactants selected from polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene sorbitol fatty acid ester.

In the present invention, one or more interfaces selected from polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene sorbitol fatty acid ester for the temporal stability (storage stability) of vanillyl alkyl ether as a warming component. This is achieved by the presence of an activator. Due to the presence of such a specific surfactant, even if the vanillyl alkyl ether is stored for a long period of time, the warming effect of the vanillyl alkyl ether can be surely realized.
When a cold sensation-imparting ingredient is further added to the skin external preparation composition of the present invention, when the skin external preparation composition of the present invention is applied to the body, particularly the neck and / or shoulders, the cooling sensation-imparting ingredient has an immediate effect and lasts. A feeling of coolness occurs. After this cool feeling, a warm feeling is generated by vanillyl alkyl ether as a warm feeling imparting component. In this series of processes, not only a synergistic effect of reducing stiffness of the body but also a synergistic feeling of relaxation due to the warming sensation-imparting component and the cooling sensation-imparting component can be obtained. Furthermore, the relaxing effect can be enhanced by adding a stress-reducing ingredient having a unique scent.
Therefore, the present invention provides a skin external preparation composition capable of enhancing the relaxing effect of the user and reducing stiffness of the shoulders and neck by having a unique scent as well as a feeling of coldness and a continuous warmth after application to the body. provide.

The present invention is characterized by comprising (a) a vanillyl alkyl ether and (b) one or more surfactants selected from polyoxyethylene polyoxypropylene alkyl ethers and polyoxyethylene sorbitol fatty acid esters. The present invention relates to an external preparation for skin, and an external preparation for reducing stiffness of the body containing the external preparation for skin. Furthermore, the present invention relates to a stabilizer for vanillyl alkyl ethers, which contains one or more surfactants selected from polyoxyethylene polyoxypropylene alkyl ethers and polyoxyethylene sorbitol fatty acid esters. Hereinafter, each component will be described in detail.

上記バニリルアルキルエーテルのアルキル基（上記一般式中のＲ₁）は、置換されていてもいなくてもよく、直鎖または分岐鎖であってもよく、飽和または不飽和であってもよい、例えば炭素数が１〜１０、好ましくは２〜８、より好ましくは３〜６のアルキル基であり得る。置換基としては、例えば、ハロゲン、炭素数が１〜１０、好ましくは２〜８、より好ましくは３〜６のアルキル基が挙げられる。より具体的には、上記バニリルアルキルエーテルの好ましい例は、バニリルブチルエーテル、バニリルプロピルエーテル、及びバニリルペンチルエーテルから選択され得る。 (A) Vanillyl alkyl ether (a) The component vanillyl alkyl ether is an active ingredient in the external preparation composition for skin of the present invention, and is a hypoallergenic and warming component that provides a good warmth. used. Here, the term “warm feeling” refers to a feeling of warmth when the composition of the present invention is used as a poultice and the poultice is applied to the affected area (on the skin). Although not limited to the mechanism for imparting a feeling of warmth, for example, the action of the component (a) promotes blood circulation, so that a person may feel warmth.
The vanillyl alkyl ether of the component (a) is represented by the following general formula (I).

The alkyl group of the vanillyl alkyl ether (R ₁ in the general formula above) may be substituted, linear or branched, saturated or unsaturated. For example, it can be an alkyl group having 1 to 10, preferably 2 to 8, more preferably 3 to 6 carbon atoms. Examples of the substituent include halogens and alkyl groups having 1 to 10, preferably 2 to 8 carbon atoms, and more preferably 3 to 6 carbon atoms. More specifically, preferred examples of the vanillyl alkyl ethers can be selected from vanillyl butyl ethers, vanillyl propyl ethers, and vanillyl pentyl ethers.

The content of each one of the component (a) in the external preparation composition for skin of the present invention is appropriately 0.001 to 5% by mass, preferably 0.05, based on the total mass of the external preparation composition for skin. It is ~ 3% by mass, more preferably 0.01 to 1% by mass, and particularly preferably 0.05 to 0.5% by mass. When the content of each one of the warmth-imparting components is 0.001% by mass or more, a sufficient warmth is obtained, and when it is 5% by mass or less, usability is not impaired, which is preferable.

The total content of the component (a) in the external preparation composition for skin of the present invention is, for example, 0.001 to 20% by mass, preferably 0, based on the total mass of the external preparation composition for skin. It is .005 to 15% by mass, more preferably 0.01 to 10% by mass, and particularly preferably 0.05 to 1% by mass.

(B) Surfactant The external preparation composition for skin of the present invention may contain one or more surfactants selected from polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene sorbitol fatty acid ester.
The polyoxyethylene polyoxypropylene alkyl ether has a structure as shown in the following general formula (II).

R ₂ O [CH ₂ CH ₃ CHO] _m [CH ₂ CH ₂ O] _n H (II)

In formula (II), R ₂ may be substituted, linear or branched, saturated or unsaturated, eg, having 1-30 carbon atoms, preferably Can be 3-25, more preferably 5-20, even more preferably 8-18 alkyl groups. Examples of the substituent include a halogen and an alkyl group having 1 to 20, preferably 3 to 15, and more preferably 6 to 12 carbon atoms. m may be, for example, 1 to 50, preferably 1 to 35, and more preferably 3 to 30. n may be, for example, 1 to 30, preferably 2 to 25, and more preferably 2 to 20. Specific examples of the polyoxyethylene polyoxypropylene alkyl ether include polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyl ether, and the like. it can. More specifically, POE (n) POP (m) decyltetradecyl ether, POE (n) POP (m) cetyl ether, POE (n) POP (m) decyl ether, and the like can be mentioned (here). m and n are as defined above).

式（ＩＩＩ）中、Ｒ₃〜Ｒ₅は、それぞれ独立に、置換されていてもいなくてもよく、直鎖または分岐鎖であってもよく、飽和または不飽和であってもよい、例えば炭素数が１〜３０、好ましくは３〜２５、より好ましくは５〜２０、さらに好ましくは１０〜１８の脂肪酸エステル基、若しくは水素であり得る。ｓ、ｔ及びｕは合計数で、例えば１〜１００、好ましくは３〜８０、より好ましくは５〜６０であってもよい。各ｓ、ｔ及びｕは同一であっても互いに±１〜１０、もしくは±２〜５程度相違していてもよい。具体的なポリオキシエチレンソルビット脂肪酸エステルとしては、例えば、ポリオキシエチレンソルビットテトラオレイン酸エステル、ポリオキシエチレンソルビットテトラステアリン酸エステル、ポリオキシエチレンソルビットモノラウリン酸エステル、ポリオキシエチレンソルビットテトライソステアリン酸エステル等を挙げることができる。より具体的には、テトラオレイン酸ＰＯＥ（ｖ）ソルビット、テトラステアリン酸ＰＯＥ（ｖ）ソルビット、モノラウリン酸ＰＯＥ（ｖ）ソルビット、テトライソステアリン酸ＰＯＥ（ｖ）、等を挙げることができる（ここでｖはｓ、ｔ及びｕの合計数を表す。） The polyoxyethylene sorbitol fatty acid ester has a structure as shown in the following general formula (III).

In formula (III), R _{3 to} R ₅ may be independently substituted, linear or branched, saturated or unsaturated, eg, carbon. The number can be 1-30, preferably 3-25, more preferably 5-20, still more preferably 10-18 fatty acid ester groups, or hydrogen. The total number of s, t and u may be, for example, 1 to 100, preferably 3 to 80, and more preferably 5 to 60. Each s, t and u may be the same or may differ from each other by about ± 1 to 10 or ± 2 to 5. Specific examples of the polyoxyethylene sorbit fatty acid ester include polyoxyethylene sorbit tetraoleic acid ester, polyoxyethylene sorbit tetrastearic acid ester, polyoxyethylene sorbit monolauric acid ester, and polyoxyethylene sorbit tetraisostearic acid ester. Can be mentioned. More specifically, POE (v) sorbitol tetraoleate, POE (v) sorbitol tetrastearate, POE (v) sorbitol monolaurate, POE tetraisostearate (v), and the like can be mentioned (here v). Represents the total number of s, t and u.)

The HLB value of the component (b) is preferably, for example, 10.5 or less, preferably 9.7 or less, more preferably 8.7 or less, and usually, for example, 0 or more, preferably 1 or more, more preferably. It is appropriate that is 1 or more.
The HLB value is calculated by the following formula.
HLB = 20 × (sum of molecular weight of hydrophilic part of component (b) / molecular weight of component (b))

The surfactant of the component (b) is used as a stabilizer of the vanillyl alkyl ether of the component (a). In addition, the surfactant of the component (b) can also be used as a solubilizing agent or a moisturizing component. When used as a stabilizer, the component (b) is polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyl ether, polyoxyethylene sorbit tetraoleic acid. Particularly preferably, the ester is a polyoxyethylene sorbit tetrastearic acid ester.
The content of these surfactants is preferably, for example, 0.001 to 20% by mass, preferably 0.005 to 10% by mass, and more preferably 0.01, based on the total mass of the external preparation composition for skin. It is ~ 6% by mass, particularly preferably 0.05 to 1% by mass, and particularly preferably 0.08 to 0.2% by mass. If this amount is 0.001% by mass or more, a sufficient moisturizing effect can be obtained, and if it is 20% by mass or less, usability is not impaired, which is preferable.
The mass ratio of the component (b) to the component (a) is, for example, 1/10 to 100/1, preferably 1/1 to 70/1, and more preferably 10/1 to 50 /. It is 1, particularly preferably 15/1 to 40/1, and particularly preferably 25/10 to 35/1.

(C) Cooling sensation-imparting component The cooling sensation-imparting component, which is an optional component of the present invention, can be selected from menthol, l-menthylglyceryl ether and ethanol.
When these menthol, l-menthylglyceryl ether and ethanol are applied to the skin, a cool feeling is obtained. Although not bound by theory, the cool sensation may be felt cold when the heat of vaporization is taken from the skin or when the cold sensation point of the skin is stimulated. Of these, ethanol is preferable because it has a higher property of removing heat of vaporization than other components that impart a feeling of cooling. In particular, by including the component (c) in the external preparation composition for skin of the present invention, it is possible to provide a cool feeling immediately after the composition is applied to the body and then a warm feeling. In addition, it can provide an external preparation that has a peculiar scent, enhances the relaxing effect of the user, and can reduce stiffness of the shoulders and neck.

Although not influenced by theory, menthol and l-menthylglyceryl ether, which can be used as cooling sensation-imparting components, act on nerves that feel cooling sensation to obtain a cooling sensation. The respective contents of menthol and l-menthylglyceryl ether are preferably, for example, 0.001 to 5% by mass, preferably 0.01 to 3% by mass, particularly, based on the total mass of the external preparation composition for skin. It is preferably 0.1 to 1% by mass. When the content of menthol and l-menthylglyceryl ether is 0.001% by mass or more, a sufficient cooling sensation can be obtained, and when it is 5% by mass or less, usability is not impaired, which is preferable.

As the ethanol that can be used in the present invention, ethanol that is widely and generally used in pharmaceuticals, cosmetics, foods such as alcohol, miscellaneous goods such as disinfectants, petrochemical industry, and paint industry can be used. Commercially available ethanol has several purity, for example, purity 77% by volume, purity 95% by volume, purity 99% by volume, etc., but any purity ethanol can be used. In addition, a type in which a metamorphic component such as brucine is mixed with ethanol and processed so that it cannot be used for drinking is commercially available, but this can also be used.
The content of ethanol in the external preparation composition for skin of the present invention is based on the total mass of the external preparation composition for skin, assuming that the purity of ethanol is 95% by mass (hereinafter, the same applies to ethanol). For example, 3 to 30% by mass is suitable, preferably 5 to 20% by mass, and particularly preferably 7 to 15% by mass. If the content of ethanol is 3% by mass or more, a sufficient cooling sensation can be obtained, and if it is 30% by mass or less, usability is not impaired, which is preferable.

The total content of the cooling sensation-imparting component contained in the skin external preparation composition of the present invention is, for example, 0.01 to 40% by mass, preferably 0, based on the total mass of the skin external preparation composition. .1 to 30% by mass, more preferably 0.5 to 20% by mass, and particularly preferably 1 to 15% by mass. The mass ratio of the component (c) to the component (a) is, for example, 1/10 to 300/1, preferably 1/1 to 200/1, and more preferably 10/1 to 150/1. It is particularly preferably 50/1 to 130/1, and particularly preferably 80/1 to 120/1.
When menthol and / or l-mentyl glyceryl ether and ethanol are used as the above-mentioned cooling sensation-imparting component, the ratio of the mass of ethanol of the cooling sensation-imparting component to the total mass of menthol and l-mentyl glyceryl ether is, for example, [menthol. And the total mass of l-menthol glyceryl ether]: [mass of ethanol] = 1: 100 to 1: 1, preferably 1: 70 to 1: 2, more preferably 1: 50 to 1: 1. 5, particularly preferably 1:30 to 1:10.

As the cooling sensation-imparting component, components other than menthol, l-menthylglyceryl ether and ethanol (other cooling sensation-imparting components) can be blended within a range that does not impair the effects of the present invention. Other cooling sensation-imparting ingredients include, for example, menthone, camphor, pregol, isopulegol, cineole, butane oil, peppermint oil, spare mint oil, eucalyptus oil, N-alkyl-p-menthan-3-carboxamide, 2-methyl-. 3- (l-Mentoxy) Propane-1,2-diol, p-menthane-3,8-diol, 2- (l-mentoxy) ethane-1-ol, 3- (l-mentoxy) propane-1-ol , 4- (L-mentoxy) butane-1-ol, menthyl 3-hydroxybutanoate, menthyl lactate, menthone lycerin ketal, N-methyl-2,2-isopropylmethyl-3-methylbutaneamide, or menthyl glycylate Can be mentioned. The total content of the other cooling sensation-imparting components contained in the skin external preparation composition of the present invention is preferably, for example, 0.001 to 5% by mass, based on the total mass of the skin external preparation composition. Is 0.01 to 3% by mass, particularly preferably 0.1 to 1% by mass.

The total content of each of the above-mentioned components (a), (b) and (c) is preferably 1 to 50% by mass, preferably 2 to 40% by mass, based on the total mass of the external preparation composition for skin. %, More preferably 3 to 30% by mass, and particularly preferably 5 to 25% by mass.

[Other ingredients]
In addition to the above ingredients, the external preparation composition for skin of the present invention may contain a base ingredient, a medicinal ingredient and the like that are usually used depending on the purpose and dosage form. Examples of such base components and medicinal components include mineral / synthetic oils, animal and vegetable oils, waxes, fatty acids, alcohols, ester oils, silicon oils, surfactants, wetting agents, polymer compounds, animal and plant extracts, amino acids. Types, solvents, vitamins, anti-inflammatory agents, preservatives, UV absorbers, metal ion sequestering agents, antioxidants, pH regulators, pigments / pigments, fragrances and the like. These other components can be blended as long as the effects of the present invention are not impaired. The content of other components depends on the type of component, but for example, 99 to 50% by mass is appropriate, preferably 98 to 60% by mass, and more preferably 98% by mass, based on the total mass of the external preparation composition for skin. It is 97 to 70% by mass, particularly preferably 95 to 75% by mass. Specific examples of other components are given below.
(A)'Other warmth-imparting components As other warmth-imparting components other than the above-mentioned component (a), components other than vanillyl alkyl ether can be blended within a range that does not impair the effects of the present invention. Other warming-imparting ingredients include, for example, pepper tincture, ginger tincture, capsaicin, gingerol, 4- (l-mentoxymethyl) -2- (3'-methoxy-4'-hydroxyphenyl) -1,3. -Dioxolan, peppermint oil, peppermint oleoresin, ginger oleoresin, nonylate vanillylamide, jumbu oleoresin, sansho extract, sunshoal-I, sunshoal-II, sanshoamide, black pepper extract, capsaicin, piperin or spirantol Can be mentioned. The total content of the other warming-imparting components contained in the external preparation composition for skin of the present invention is preferably, for example, 0.001 to 5% by mass, based on the total mass of the external preparation composition for skin. Is 0.01 to 3% by mass, particularly preferably 0.1 to 1% by mass.

(B)'Other surfactants Examples of other surfactants include lauryl sulfate, alkyl sulfate, polyoxyethylene alkyl sulfate, tetradecene sulfonate, polyoxyethylene alkyl sulfosuccinate, and lauroyl sarcosin. Salts, alkylmethyl-β-alanine salts, polyoxyethylene alkyl ether phosphates, fatty acid soaps, N-acylglutamates, laurate diethanolamides, palm oil fatty acid diethanolamides, alkyldimethylamine oxides, alkylmethyl taurine salts, alkyls Aminoprocionate, polyoxyethylene alkyl ether carboxylate, alkyl phosphate, alkyl glucoside, polyether-modified silicon, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, amidoamine, dialkyldimethylammonium chloride dimethylacetate betaine, alkylamide Propyl betaine, alkylcarboxymethyl hydroxyethyl imidazolinium betaine, lecithin (derived from soybean or egg yolk) and its derivatives, propylene glycol fatty acid ester, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene Hardened castor oil, polyethylene glycol fatty acid ester, polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl nonylphenyl ether, polyoxyethylene alkyl Examples thereof include ether phosphate / phosphate, sucrose fatty acid ester, and among these, one type or a combination of two or more types can be used.
These other surfactants are also used as solubilizers, but may also be used as moisturizing ingredients. When used as a moisturizing component, a nonionic surfactant which is an EO adduct of vegetable oil is particularly excellent, and one or more kinds can be used. Among the nonionic surfactants, for example, polyoxyethylene glycerin fatty acid ester, polyoxyethylene cured castor oil and polyoxyethylene polyoxypropylene glycol are preferably used.
The content of these nonionic surfactants is preferably 0.001 to 20% by mass, preferably 0.01 to 10% by mass, and particularly preferably 0.1, based on the total mass of the external preparation composition for skin. ~ 6% by mass. If this amount is 0.001% by mass or more, a sufficient moisturizing effect can be obtained, and if it is 20% by mass or less, usability is not impaired, which is preferable.

(D) Stress-reducing component The external preparation composition for skin of the present invention may contain cis-3-hexene-1-ol as a stress-reducing component having a unique scent.
Sis-3-hexene-1-ol, also called green leaf alcohol, is a stress-reducing ingredient with a unique scent. When cis-3-hexene-1-ol is contained in an external preparation composition for skin such as cosmetics, cis-3-hexene-1-ol slowly volatilizes after the composition is applied to the skin, and at the same time, aroma. Is obtained. By smelling this fragrance, stress can be reduced and a relaxing effect can be obtained, which in turn can reduce stiffness of the body such as shoulders and neck. Since the volatilization amount of cis-3-hexene-1-ol is synergistically improved by the vaporization action of the above-mentioned cooling sensation-imparting component, in the present invention, the cooling sensation-imparting component and cis-3-hexene-1-ol are used. The combination is important.
The cis-3-hexen-1-ol that can be added to the external preparation composition for skin of the present invention is widely and generally used in pharmaceuticals, cosmetics, foods, miscellaneous goods, petrochemical industry, paint industry and the like. is there. Commercially available products can be used in the present invention.
The content of cis-3-hexen-1-ol having a unique scent in the external preparation composition for skin of the present invention is, for example, 0.001 to 20% by mass, based on the total mass of the external preparation composition for skin. It is preferably 0.005 to 10% by mass, more preferably 0.01 to 5% by mass, particularly preferably 0.01 to 3% by mass, and particularly preferably 0.1 to 1% by mass. If this amount is 0.001% by mass or more, a relaxing effect due to sufficient stress reduction can be obtained, and if it is 20% by mass or less, usability is not impaired, which is preferable.
As the stress-reducing component, components other than cis-3-hexene-1-ol (other stress-reducing components) can be blended within a range that does not impair the effects of the present invention. Other stress-relieving ingredients include, for example, lavender, melissa, benzoin, bergamot, vetiver, frankincense, petitgrain, patchouli, neroli, geranium, sweet marjoram, sandalwood (sandalwood), cypress, clary sage, chamomile roman, and Iran Iran. be able to. The total content of the other stress-relieving ingredients contained in the external preparation composition for skin of the present invention is, for example, 0.001 to 5% by mass, preferably 0.001 to 5% by mass, based on the total mass of the external preparation composition for skin. It is 0.01 to 3% by mass, particularly preferably 0.1 to 1% by mass.
(E) Polyhydric alcohol Examples of the polyhydric alcohol include glycerin, diglycerin, sorbit solution, polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol and the like, and one of them or Two or more types can be used in combination. The total content of the polyvalent alcohol contained in the external preparation composition for skin of the present invention is, for example, 0.01 to 20% by mass, preferably 0.01 to 20% by mass, based on the total mass of the external preparation composition for skin. It is 1 to 15% by mass, particularly preferably 1 to 10% by mass.

(F) Silicon oil Examples of silicon oil include methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane, silicon resin, methylhydrogenpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, and decamethylcyclopentasiloxane. , Dodecamethylcyclohexasiloxane, cyclic silicon resin, octamethyltrisiloxane, tetradecamethylhexasiloxane, highly polymerized methylpolysiloxane, trimethylsiloxysilicate, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, poly ( Oxyethylene / oxypropylene) / butylene / methylpolysiloxane copolymer, polyoxyethylene / methylpolysiloxyic acid copolymer, polyoxypropylene / methylpolysiloxane copolymer, dimethylpolysiloxane / methylcetyloxysiloxane copolymer , Dimethylsiloxane / Methylstealoxysiloxane copolymer and the like, and one or a combination of two or more of these can be used.

(G) Preservatives Examples of preservatives include methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, bisabolol, hinokithiol, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, sorbic acid, potassium sorbate. , Undecylenoic acid, pionin, l-menthol, d-camfur, isopropylmethylphenol, benzethonium chloride, alkyldiaminoethylglycine hydrochloride and the like, and one or a combination of two or more of these can be used. The total content of the preservatives contained in the external preparation composition for skin of the present invention is, for example, 0.001 to 10% by mass, preferably 0.01, based on the total mass of the external preparation composition for skin. ~ 5% by mass, particularly preferably 0.1 to 1% by mass.
(H) Thickener Examples of the thickener include alginates such as carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate, and ammonium alginate. And its derivatives, xanthan gum, guar gum, gelatin, agar, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, carboxyvinyl polymer (carbomer), alginic acid-based copolymers, polyacrylamide, hyaluronic acid, sodium hyaluronate, sodium polyacrylate, etc. Of these, one type or a combination of two or more types can be used. The total content of the thickener contained in the skin external preparation composition of the present invention is, for example, 0.001 to 10% by mass, preferably 0.001 to 10% by mass, based on the total mass of the skin external preparation composition. It is 01 to 5% by mass, particularly preferably 0.1 to 1% by mass.

(I) Acid adjuster Examples of the pH adjuster include citric acid, glycolic acid, malic acid, tartaric acid, lactic acid, succinic acid, phosphoric acid and salts thereof, and sodium hydroxide, potassium hydroxide, sodium hydrogen carbonate and the like. Can be mentioned. Of these pH regulators, one or a combination of two or more can be used. The total content of the pH adjuster contained in the external preparation composition for skin of the present invention is preferably, for example, 0.001 to 5% by mass, preferably 0.% by mass, based on the total mass of the external preparation composition for skin. It is 005 to 1% by mass, particularly preferably 0.01 to 0.1% by mass.
(J) Solvent Examples of the solvent include water such as purified water or normal water, isopropanol, and alcohols other than ethanol such as benzyl alcohol, and one or a combination of two or more of these may be used. it can. The amount of the solvent may be the balance after adding each component of the external preparation composition for skin of the present invention. When the solvent is water, the lower limit of the amount of water is, for example, 40% by mass or more, preferably 50% by mass or more, more preferably 60% by mass or more, and further, based on the total mass of the external preparation composition for skin. It is preferable that it is 70% by mass or more, particularly preferably 80% by mass or more, and the upper limit of water is, for example, 95% by mass or less, preferably 90% by mass or less, more preferably 85% by mass or less, and further. It is preferably 80% by mass or less. The above lower limit value and upper limit value can be applied even when the solvent is other than water.
When purified water or water such as normal water is used as the solvent, the content of water is preferably 1 to 95% by mass, preferably 10 to 90% by mass, based on the total mass of the external preparation composition for skin. Yes, more preferably 50-88% by mass. When the external preparation composition for skin is a liquid or a viscous liquid, the content of the water is, for example, 60 to 90% by mass, more preferably 65 to 88% by mass.

(K) Oils In addition to the above silicon oils, minerals, synthetic oils, animal and vegetable oils, waxes, ester oils and the like can be used as oils.
Specifically, examples of the mineral / synthetic oil include liquid paraffin, liquid isoparaffin, petrolatum, paraffin, ceresin, microstalin wax, α-olefin oligomer, polyethylene, polybutene, synthetic squalane, and the like. Species or a combination of two or more can be used.
Animal and vegetable oils include, for example, squalane, olive oil, camellia oil, wheat germ oil, jojoba oil, avocado oil, carrot oil, shea butter, liquid shea butter, palm oil, palm kernel oil, hardened oil, horse oil, lanolins. , Egg yolk oil, butterfly oil, rose hip oil, lavender oil, peppermint oil, sparemint oil, rosemary oil, macadamia nut oil, apricot oil, saflower oil, sunflower oil, medu home oil, almond oil, egoma oil, sesame oil, borage Oil, cacao butter, rice bran oil, rice germ oil, oyster oil, orange oil, chamomile oil, cucumber oil, kukui nut oil, soybean oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, Mink oil, Argania spisa kernel oil, Cranbear bicinica seed oil, Almond oil, Persic oil, Peach seed oil, Grape seed oil, Emu oil, Mink oil, Asa seed oil, Amani oil, Southern ka oil, Mokurou, Palm oil, Evening primrose oil , Pistacio seed oil, mango butter and the like, and one or a combination of two or more of these can be used.

Examples of waxes include jojoba oil, beeswax, carnauba wax, rice wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, celac, orange raffy oil and the like. One type or a combination of two or more types can be used.
Examples of the ester oil include glyceryl tricaprylate, glyceryl tri2-ethylhexanoate, isononyl isononanoate, ethylene glycol dioctanoate, glyceryl tri (caprylic acid / caprylic acid), isopropyl myristate, butyl myristate, and isopropyl palmitate. Ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, decyl myristate, hexyl laurate, myristyl myristate, cetyl myristate, cetyl palmitate, stearyl stearate, oleic acid Oleyl, decyl oleate, cetyl ricinolate, isostearyl laurate, isotolideyl myristate, isosetyl myristate, isostearyl myristate, 2-octyldodecyl myristate, ethylhexyl palmitate, isosetyl palmitate, ethylhexyl stearate, isosetil stearate , Isodecyl oleate, 2-octyldodecyl oleate, 2-octyldodecyl ricinolate, ethyl isostearate, isopropyl isostearate, cetyl octanate, cetostearyl octanate, stearyl octanate, hexyl isostearate, ethylene glycol dioleate, dicaprylic acid Propylene glycol acid, propylene glycol di (caprylic capric acid), propylene glycol dioleate, neopentyl glycol dicaprate, neopentyl glycol di2-ethylhexanate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, Trimethylolpropane tri2-ethylhexanoate, trimethylrolpropane triisostearate, pentaerythritol tetra2-ethylhexanoate, pentaerythritol tetramyristate, pentaerythritol tetraisostearate, 2-octyldodecyl neopentanoate, isocetyl octane, octane Isostearyl acid, ethylhexyl isoperanoate, 2-hexyldecyl neodecanoate, 2-octyldodecyl neodecanoate, ethylhexyl isopalmitate, isosetyl isostearate, isostearyl isostearate, 2-octyldodecyl isostearate, lauryl lactate, myristyl lactate, lactic acid Cetyl, 2-octyldodecyl lactate, triethyl citrate, ace citrate Tiltriethyl, acetyltributyl citrate, tri2-ethylhexyl citrate, triisocetyl citrate, tri2-octyldodecyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, dioctyl succinate, diisopropyl adipate, adipate Diisobutyl, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, dibutyl octyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosteryl oleate Examples thereof include phytosteryl acid acid, hexyldecyl dimethyloctanoate, cetyl lactic acid, diethyl phthalate, dibutyl phthalate, dialkyl carbonate and the like, and one or a combination of two or more of these can be used.

(L) Alcohol As the alcohol, an alcohol other than ethanol used as a cooling sensation-imparting component can be added to the skin external preparation composition of the present invention. Examples of alcohols include isopropanol, butyl alcohol, benzyl alcohol, lauryl alcohol, myristyl alcohol, setanol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, hexyldecanol, behenyl alcohol, octyldodecanol, lanolin alcohol, cholesterol and phytosterol. , 2-Hexyldecanol, 2-octyldodecanol, batyl alcohol and the like, and one or a combination of two or more of these can be used.
(M) Fatty Acids Examples of fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, behenic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, and 12-hydroxystearic acid. Natural fatty acids such as undosilenic acid and lanolin fatty acid, synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid and isopentanoic acid can be mentioned, and one or two of these can be mentioned. The above can be used in combination.
(N) Wetting agent In addition to the above polyhydric alcohol, examples of the wetting agent include ethylene oxide, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, propylene oxide, and polyoxyalkylene alkyl ether. , Of these, one type or a combination of two or more types can be used.

(O) Polymer compound Examples of the polymer compound include sodium alginate, carrageenan, agar, farcerelan, guar gum, quince seed, konjak mannan, tamarind gum, tara gum, dextrin, starch, locust bean gum, arabic gum, gatti gum, and karaya gum. , Tragacanth gum, arabinogalactan, pectin, malmero, wheat protein, soybean protein, albumin, casein, gelatin, chitosan, hyaluronic acid, carrageenan, xanthan gum, gellan gum, cyclodextrin, dextrin, purulan, hyaluronic acid, crystalline cellulose, methylcellulose, Ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, cationized cellulose, cationized guar gum, hydroxypropylated guar gum, carboxyvinyl polymer, polyacrylic acid amide, sodium polyacrylate, polyethylene imine, highly polymerized polyethylene glycol , Polyvinyl alcohol, polyvinyl pyrrolidone and the like, and one or a combination of two or more of these can be used.
(P) Animal and plant extracts Examples of animal and plant extracts include placenta extract, hydrolyzed keratin, hydrolyzed silk, yeast extract, aloe extract, comfrey extract, shakyaku extract, perilla extract, sage extract, sembly extract, hamamelis water, and hikiokoshi. Examples include extracts, hop extracts, marronnier extracts, peach leaf extracts, yukinoshita extracts, melissa extracts, yomogi extracts, rosemary extracts, fermented rice bran extracts, etc., and one or more of these can be used in combination. ..

(Q) Amino acids Examples of amino acids include L-alanine, L-arginine, L-aspartic acid, L-glutamine, L-aspartin, L-cysteine, L-serine, L-tyrosine, L-proline, and pyrrolidone. Examples thereof include carboxylate, glycine, valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, cystine, hydroxyproline, hydroxylysine, ornithine, histidine, γ-aminobutyric acid, ε-aminocaproic acid, etc. Of these, one type or a combination of two or more types can be used.
(R) Vitamins Examples of vitamins include retinol, retinoic acid, vitamin A oil, retinol acetate, ascorbyl palmitate, β-carotene, lycopene, ascorbyl, lutein, cryptoxanthin, pyridoxin hydrochloride, pyridoxin dicaprylate, and biotin. Nicotinic acid, nicotinic acid amide, benzyl nicotinate, riboflavin, folic acid, calcium pantothenate, D-pantothenyl alcohol, ascorbic acid, ascorbyl palmitate, L-ascorbyl magnesium phosphate, ascorbyl tetra2-hexyldecanoate, L-ascorbic acid 2-glucoside, ascorbic acid-2-ascorbyl palmitate, ascorbyl ethyl, ergocalciferol, dl-α-tocopherol, dl-α-tocopherol acetate, natural vitamin E, ubiquinone, carnitine, α-lipoic acid, vitamin P (Hesperidin, methyl hesperidin, rutin) and the like can be mentioned, and one or a combination of two or more of these can be used.

(S) Anti-inflammatory agent Examples of the anti-inflammatory agent include glycyrrhizinic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, guaiazulene, sodium guaiazulene sulfonate, allantoin, ε-aminocaproic acid and the like. Of these, one type or a combination of two or more types can be used.
(T) UV inhibitor Examples of the UV inhibitor include para-aminobenzoic acid, ethyl para-aminobenzoate, glyceryl para-aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate, oxybenzone, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, and dihydroxydimethoxybenzophenone sulfone. Examples thereof include sodium acid, sodium hydroxymethoxybenzophenone sulfonate, octyl salicylate, 4-tert-butyl-4'-methoxy-dibenzoylmethane, ferulic acid, titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide and the like. Of these, one type or a combination of two or more types can be used.
(U) Metal ion sequestering agent Examples of the metal ion sequestering agent include edetic acid, edetate, ethylenediaminehydroxyethyl triacetate trisodium, diethylenetriamine pentaacetic acid, diethylenetriamine pentaacetic acid pentasodium, and ethylenediaminetetrakis (2-hydroxyisopropyl) diolein. Examples thereof include acid salts, hydroxyethanedisulfonic acid, tetrasodium hydroxyethanedisulfonic acid, phytic acid and the like, and one or a combination of two or more of these can be used.
(V) Antioxidant Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, d-δ-tocopherol, and the like, and one or more of these may be used. It can be used in combination.
(W) Fragrances As fragrances, natural fragrances of animal, plant, minerals and synthetic fragrances other than fragrances such as cis-3-hexene-1-ol added as the stress-reducing component of (d) above. Any of these can be used, and one or a combination of two or more of these can be used. The total content of the fragrance contained in the external preparation composition for skin of the present invention is, for example, 0.001 to 10% by mass, preferably 0.01 to 10% by mass, based on the total mass of the external preparation composition for skin. It is 5% by mass, particularly preferably 0.1 to 1% by mass.

[Form of external preparation composition for skin]
The present invention relates to a skin external preparation composition. Here, the "external preparation" means a drug that is directly applied to the body, excluding internal medicines and injections, and particularly means a drug that is applied to the skin (outer skin). Examples of external preparations include coating agents such as ointments, creams, gels, lotions, emulsions and hair tonics; and patches such as poultices, plasters, tapes and patches. The external preparation may be a drug, a quasi drug, or a cosmetic product. The skin external preparation composition means a composition used for the external preparation.
The amount of the external preparation for skin used in the present invention depends on the type of the external preparation, but may be the amount used in a normal external preparation. The amount of the external preparation composition for skin used is, for example, 0.01 to 10 g, preferably 0.05 to 5 g, and more preferably 0.1 to 1 g per 100 cm ² of the skin surface of the body. Is.

[Evaluation of the present invention]
The external preparation composition for skin of the present invention realizes the stability of vanillyl alkyl ether, which is an active ingredient, over time (storage stability). The stability can be evaluated by measuring the residual amount of vanillyl alkyl ether over time. The stability can be evaluated by using a well-known method for measuring the storage stability of a drug or compound. For example, the change over time in the concentration of vanillyl alkyl ether can be measured by HPLC or the like. Can be evaluated by. Specifically, the vanillyl alkyl ether concentration in the external preparation immediately after preparation is measured by HPLC. Then, the external preparation is stored at 50 ° C. for 1 month, the vanillyl alkyl ether concentration is measured again in the same manner, and the residual ratio of vanillyl alkyl ether is determined from the following formula.
Vanillyl alkyl ether residual ratio (% by mass)
= (Vanillyl alkyl ether concentration after storage at 50 ° C for 1 month /
Vanillyl alkyl ether concentration immediately after preparation) x 100
It can be evaluated that the higher the residual ratio of vanillyl alkyl ether is, the higher the storage stability is. The residual ratio of the vanillyl alkyl ether is, for example, preferably 50% by mass or more, more preferably 55% by mass or more, further preferably 60% by mass or more, and particularly preferably 70% by mass or more. ..

On the other hand, the evaluation of warmth is generally judged by applying the external preparation composition for skin of the present invention directly to the body and performing a sensory evaluation by a plurality of panelists. For example, the skin external preparation composition is applied to a plurality of panelists, and the warmth felt after being left for 3 to 10 minutes, preferably about 5 minutes, is scored for judgment.

[External agent]
The external preparation for skin of the present invention may be used for preparing an external preparation for reducing stiffness of the body. "Body stiffness" means situations such as muscle fatigue, poor circulation, and nerve compression in various parts of the body such as the neck, shoulders, hips, arms, and legs. The external preparation composition for skin of the present invention causes these symptoms by satisfactorily sustaining the warming sensation based on the vanillyl alkyl ether which is the component (a) by the specific surfactant which is the component (b). It can be appropriately reduced or eliminated.

[Preparation of external preparation for skin composition]
The skin external preparation composition of the present invention may use a well-known method for producing an external preparation, but preferably, a part of the components used is mixed with a solvent to prepare a gel, and the rest thereof. It is appropriate to add the ingredients to the gel to obtain the external preparation composition for skin of the present invention.
Specific preparation methods include, for example, the following. First, (h) the thickener is dispersed in (j) a solvent, and the temperature is 20 to 80 ° C., preferably 30 to 70 ° C., more preferably 40 to 60 ° C. for 10 to 120 minutes, preferably 20 to 90 minutes. , More preferably, heat and mix with stirring for 30 to 60 minutes. Then, it is cooled to 20 to 35 ° C., preferably 25 to 30 ° C. The pH of the mixed solution is adjusted by adding a solution of (i) a pH adjuster and an arbitrary (j) solvent to the cooled mixed solution (for example, pH 4.0 to 9.0, preferably pH 4). The target gel can be obtained with a pH of .5-8.5, more preferably pH 5.0-8.0). One or more surfactants selected from (a) vanillyl alkyl ether and (b) polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene sorbitol fatty acid ester, which are essential components of the present invention, in the obtained gel. The above-mentioned other ingredients can be added to obtain the skin external preparation composition of the present invention. A well-known mixer such as a homo mixer, a dispenser mixer, or a paddle mixer can be used for mixing each component during preparation.

[Container for external preparation for skin]
The external preparation composition for skin of the present invention can be filled in a suitable container depending on the hardness of the composition. For example, in the case of a liquid to loosely viscous skin external preparation composition, it can be filled in bottles, cans, packs of plastic sheets and the like. In the case of a creamy or ointment-like highly viscous skin external preparation composition, it can be filled in bottles, cans, tubes and the like.

For example, when applying the external preparation composition for skin filled in a bottle to the skin, it can be rubbed directly from the bottle onto the body or palm, or it can be directly applied to the body or palm with a dispenser that is discharged as a mist or liquid. A method of taking out and rubbing, a method of hitting the discharge part of the dome-shaped mouth tube against the body and directly putting it out to the body, and a method of rubbing with the dome-shaped mouth, a method of hitting the roll-on type discharge part against the body and discharging the external preparation There is a method of rotating the roll and rubbing it into the body.
The material of the container is not particularly specified, but includes plastics such as polyethylene, polypropylene and polyethylene terephthalate, metals such as aluminum, and glass.
[Stabilizer]
One aspect of the present invention may be a stabilizer for vanillyl alkyl ethers containing one or more surfactants selected from polyoxyethylene polyoxypropylene alkyl ethers and polyoxyethylene sorbitol fatty acid esters. The vanillyl alkyl ether is as described in the above section (a) Vanillyl alkyl ether, and the surfactant is as described in the above section (b) Surfactant. The mass ratio of the surfactant and the vanillyl alkyl ether is as shown by the mass ratio of the component (b) / component (a).
Here, "stabilization" means the stability of the active ingredient vanillyl alkyl ether over time (storage stability), and the stability has been described in the above section [Evaluation of the present invention]. It is possible to evaluate by the residual ratio of vanillyl alkyl ether.
The stabilizer of the present invention contains the above-mentioned surfactant as an active ingredient, but other components (c) to (w) described above can be further added.
Hereinafter, the present invention will be described in detail with reference to Examples and Comparative Examples, but the present invention is not limited to these descriptions.

<Sample preparation>
Each raw material was mixed with the compositions shown in Tables 1 to 4 below to obtain skin external preparation compositions of Examples and Comparative Examples. Taking Example 1 as an example, specifically, a skin external preparation composition was produced as follows. The blending amount of each component is as shown in Table 1.
First, (h) carbomer was dispersed in a part of (j) water (90% by mass based on the total amount of water), and the mixture was heated and stirred at 60 ° C. for 30 minutes using a homomixer. Then, the obtained mixed solution was cooled to 30 ° C. To the cooled mixture, a solution of (i) sodium hydroxide (j) added to the balance of water (10% by mass based on the total amount of water) was added to adjust the pH of the mixture to 6.5. The desired gel was obtained. (A) Vanillyl alkyl ether (warm-giving ingredient / active ingredient), (b) One or more surfactants selected from polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene sorbitol fatty acid ester, (c) A cooling sensation-imparting component (optional), (d) a stress-reducing component (optional) is added, and the remaining other components ((e) 1,3-butylene glycol, (e) glycerin, (g) methylparaben) are added. The mixture was stirred using a paddle mixer to obtain the skin external preparation composition of Example 1 of the present invention.
Also in Examples 2 to 20 and Comparative Examples 1 to 9, a skin external preparation composition was prepared in the same manner as in Example 1 except that the components shown in Tables 1 to 4 were used as the components. The details of the raw materials used are shown in Table 5.

<Vanillyl alkyl ether residual rate>
The vanillyl alkyl ether concentration of each external preparation immediately after preparation according to the above method was measured by HPLC. Then, the vanillyl alkyl ether concentration after storing each agent at 50 ° C. for 1 month was measured in the same manner.
Vanillyl alkyl ether residual ratio (% by mass)
= (Vanillyl alkyl ether concentration after storage at 50 ° C for 1 month /
Vanillyl alkyl ether concentration immediately after preparation) x 100

<Evaluation of warmth>
0.3 g of each external preparation was applied to one side upper arm (about 9 cm ² ) of 10 panelists, and the feeling of warmth felt 5 minutes after application was 4 levels (0 points, 1 point, 2 points, 3 points). I got an answer in. The results were averaged and the warmth was evaluated according to the following evaluation criteria (A to D).
(Evaluation item)
3 points: I felt a strong feeling of warmth 2 points: I felt a feeling of warmth 1 point: I felt a feeling of warmth slightly 0 points: I did not feel a feeling of warmth (evaluation criteria)
A: Mean value is 2.5 or more B: Mean value is 1.5 or more and less than 2.5 C: Mean value is 0.5 or more and less than 1.5 D: Mean value is less than 0.5

<Test 1>
Test 1 shows the evaluation results of the residual ratio and warmth of the vanillyl alkyl ether of the component (a) depending on the type of the surfactant. The blending amounts of the components of each Example and Comparative Example are as shown in Table 1. The surfactants used and their HLBs are shown in Table 2 (Examples) and Table 3 (Comparative Examples). As can be understood from Tables 2 and 3, when the specific surfactant of the present invention was used, a good residual ratio of vanillyl alkyl ether of the component (a) and a high warmth evaluation were obtained (Table). 2) In Table 3 in which the specific surfactant of the present invention was not used, it was not possible to obtain a good residual ratio of vanillyl alkyl ether of the component (a) and a high warmth evaluation. In addition, Examples 2, 3, 7, 10, 12 to 17, and 20 are reference examples of this invention.

Table 1

Table 3

<Test 2>
The POE (1) POP (4) cetyl ether of Example 8 having the best residual ratio of vanillyl alkyl ether in Test 1 was used as the surfactant of the component (b), and the amount of the surfactant was changed. However, the other components and blending amounts in Table 1 were the same (excluding water), and a skin external preparation composition was prepared and evaluated. The results are shown in Table 4 below.
Table 4

From the results in Table 4 above, a good vanillyl alkyl ether residual ratio (mass%) and a high warmth evaluation are obtained when the amount of POE (1) POP (4) cetyl ether is 0.01 to 10.0. I found that I could do it. On the other hand, when the amounts of POE (1) POP (4) cetyl ether are 0.001% by mass or 20.0% by mass, respectively, it is not good, but sufficient vanillyl alkyl ether residual ratio (mass%) and temperature. I was able to get a feeling evaluation.

Table 5

Claims (9)

One or more surfactants selected from (a) vanillyl alkyl ethers and (b) polyoxyethylene polyoxypropylene alkyl ethers and polyoxyethylene sorbitol fatty acid esters having an HLB of 10.5 or less.
A skin external preparation composition comprising the above, further containing 60% by mass or more of water with respect to the mass of the skin external preparation composition. The skin external preparation composition according to claim 1, wherein the mass ratio of the component (b) to the component (a) is 1/10 to 100/1. The skin external preparation composition according to claim 1 or 2, which contains 65% by mass or more of water with respect to the mass of the skin external preparation composition. The skin external preparation composition according to any one of claims 1 to 3, wherein the component (a) is selected from vanillyl butyl ether, vanillyl propyl ether, and vanillyl pentyl ether. The skin external preparation composition according to any one of claims 1 to 4, further containing a cooling sensation-imparting component selected from menthol, l-menthylglyceryl ether, and ethanol as a component (c). The skin external preparation composition according to any one of claims 1 to 5, further containing cis-3-hexene-1-ol as a stress-reducing component as a component (d). The skin external preparation composition according to any one of claims 1 to 6, which is a coating agent or a patch. An external preparation for reducing body stiffness by imparting a feeling of warmth, which contains the skin external preparation composition according to any one of claims 1 to 7. One or more surfactants selected from polyoxyethylene polyoxypropylene alkyl ethers and polyoxyethylene sorbitol fatty acid esters having an HLB of 10.5 or less have a mass ratio of the surfactant / vanillyl alkyl ether. A stabilizer for vanillyl alkyl ether in an aqueous system containing 60% by mass or more of water, which is contained so as to be 1/10 to 100/1.