JP6746619B2 - マイクロ流体デバイス - Google Patents

マイクロ流体デバイス Download PDF

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Publication number
JP6746619B2
JP6746619B2 JP2017563516A JP2017563516A JP6746619B2 JP 6746619 B2 JP6746619 B2 JP 6746619B2 JP 2017563516 A JP2017563516 A JP 2017563516A JP 2017563516 A JP2017563516 A JP 2017563516A JP 6746619 B2 JP6746619 B2 JP 6746619B2
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fluid
layers
layer
outlet
particles
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Japanese (ja)
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JP2018528391A5 (https=
JP2018528391A (ja
Inventor
ルイス ブライドル ヘレン
ルイス ブライドル ヘレン
マクスデル ミラー ブライアン
マクスデル ミラー ブライアン
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ヘリオツト・ワツト・ユニバーシテイ
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
JP2017563516A 2015-06-11 2016-06-10 マイクロ流体デバイス Active JP6746619B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1510189.2 2015-06-11
GBGB1510189.2A GB201510189D0 (en) 2015-06-11 2015-06-11 Microfluidic device
PCT/GB2016/051713 WO2016198880A1 (en) 2015-06-11 2016-06-10 Microfluidic device

Publications (3)

Publication Number Publication Date
JP2018528391A JP2018528391A (ja) 2018-09-27
JP2018528391A5 JP2018528391A5 (https=) 2020-08-20
JP6746619B2 true JP6746619B2 (ja) 2020-08-26

Family

ID=53784509

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017563516A Active JP6746619B2 (ja) 2015-06-11 2016-06-10 マイクロ流体デバイス

Country Status (12)

Country Link
US (1) US10688490B2 (https=)
EP (1) EP3307436B1 (https=)
JP (1) JP6746619B2 (https=)
AU (1) AU2016276131B2 (https=)
BR (1) BR112017026602A2 (https=)
CA (1) CA3027154C (https=)
DK (1) DK3307436T3 (https=)
ES (1) ES2784933T3 (https=)
GB (1) GB201510189D0 (https=)
PL (1) PL3307436T3 (https=)
PT (1) PT3307436T (https=)
WO (1) WO2016198880A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108495809B (zh) * 2016-01-28 2023-04-25 明测生物医疗有限公司 使用微流体装置的多段式靶细胞富集
EP4241549A3 (en) 2016-11-07 2024-03-20 Climate LLC Agricultural implement for soil analysis
PL3821223T3 (pl) 2018-07-10 2025-03-03 Precision Planting Llc Układ do pobierania próbek rolniczych i powiązane sposoby
GB201820944D0 (en) 2018-12-21 2019-02-06 Ufraction8 Ltd Microfluid device
KR102370142B1 (ko) * 2020-03-23 2022-03-04 프레스티지바이오로직스 주식회사 항체 의약품 제조를 위한 배양 및 정제 공정의 하이브리드 시스템
US20230285969A1 (en) * 2022-03-10 2023-09-14 City University Of Hong Kong Microfluidic chamber, microfluidic device containing a water purification system, and a water purification method
CN114558631B (zh) * 2022-03-17 2023-04-07 中南大学 一种微流控设备、微流体样品输入系统及控制方法
CN115069134B (zh) * 2022-07-07 2023-09-05 山东省科学院能源研究所 一种基于迪恩涡流的微流体高效混合器
WO2025233956A1 (en) * 2024-05-07 2025-11-13 Indian Institute Of Technology Hyderabad An integrated lab on chip device for the isolation, lysis and detection of pathogen from body fluids

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2923436B2 (ja) * 1993-10-13 1999-07-26 株式会社ファインクレイ 懸濁質粒子の分級方法
JP2004330008A (ja) * 2003-05-01 2004-11-25 Rikogaku Shinkokai マイクロチャンネル装置
US7160025B2 (en) * 2003-06-11 2007-01-09 Agency For Science, Technology And Research Micromixer apparatus and methods of using same
EP1915467A2 (en) * 2005-08-19 2008-04-30 The Regents of the University of California Microfluidic methods for diagnostics and cellular analysis
JP2007148981A (ja) * 2005-11-30 2007-06-14 Univ Waseda 微粒子分別マイクロシステムおよび微粒子分別方法
US10052571B2 (en) * 2007-11-07 2018-08-21 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
US9486812B2 (en) * 2006-11-30 2016-11-08 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation
WO2010104597A2 (en) * 2009-03-13 2010-09-16 President And Fellows Of Harvard College Scale-up of microfluidic devices
JP5459471B2 (ja) * 2009-07-16 2014-04-02 富士ゼロックス株式会社 送液方法及び分級方法
US8208138B2 (en) 2009-09-24 2012-06-26 University Of Cincinnati Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems
US9458489B2 (en) * 2010-03-04 2016-10-04 Massachusetts Institute Of Technology Microfluidics sorter for cell detection and isolation
US9149806B2 (en) 2012-01-10 2015-10-06 Biopico Systems Inc Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics
WO2014046621A1 (en) * 2012-09-21 2014-03-27 Massachusetts Institute Of Technology Micro-fluidic device and uses thereof
US9804068B2 (en) * 2012-09-28 2017-10-31 University Of Maryland Particle separation and concentration using spiral inertial filtration
US9994839B2 (en) 2013-01-16 2018-06-12 The Regents Of The University Of California Microfluidic devices to extract, concentrate and isolate molecules
US10371622B2 (en) * 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
WO2015009688A1 (en) * 2013-07-17 2015-01-22 The Johns Hopkins University Microfluidic chip for analysis of cell motility and methods for using same
EP3055066A4 (en) * 2013-10-07 2017-06-14 Yeda Research and Development Co., Ltd. Microfluidic device for analyzing gene expression
RU2016118626A (ru) 2013-10-16 2017-11-21 Клирбридж Байомедикс Пте Лтд Микрогидродинамический сортер для выявления и изоляции клеток

Also Published As

Publication number Publication date
GB201510189D0 (en) 2015-07-29
ES2784933T3 (es) 2020-10-02
EP3307436A1 (en) 2018-04-18
AU2016276131A1 (en) 2017-12-14
US20180185845A1 (en) 2018-07-05
WO2016198880A1 (en) 2016-12-15
BR112017026602A2 (pt) 2018-08-14
DK3307436T3 (da) 2020-04-27
EP3307436B1 (en) 2020-03-25
CA3027154A1 (en) 2016-12-15
JP2018528391A (ja) 2018-09-27
AU2016276131B2 (en) 2021-09-30
PT3307436T (pt) 2020-04-22
CA3027154C (en) 2023-03-21
PL3307436T3 (pl) 2020-08-24
US10688490B2 (en) 2020-06-23

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