JP6721477B2 - Chemical dosing device - Google Patents

Description

The present invention relates to a drug solution administration device, and for example, to a drug solution administration device for performing continuous drug solution administration such as an insulin pump.

2. Description of the Related Art In recent years, a therapeutic method for continuously administering a drug solution into a patient's body by subcutaneous injection or intravenous injection has been performed. For example, as a treatment method for diabetic patients, a treatment of continuously injecting a small amount of insulin into the body of the patient has been carried out. In this treatment method, in order to administer the drug solution (insulin) to the patient throughout the day, a portable drug solution administration device (so-called insulin pump) that is fixed to the patient's body or clothes and can be carried is used.

As one of such portable drug solution administration devices, a syringe pump type device having a syringe for storing a drug solution and a pusher driven inside the syringe has been proposed. In addition, the conventional drug solution administration device detects the torque applied to the drive unit that operates the pusher, the amount of the drug solution filled in the syringe from the switch provided in the syringe, and the blockage of the flow path of the drug solution. (See, for example, Patent Document 1).

International Publication No. 2004/030717

However, with the torque of the conventional drive unit and the switch provided in the syringe, it is difficult to perform highly accurate occlusion detection, and it has been impossible to accurately detect the amount of the drug solution stored in the syringe. ..

An object of the present invention is to provide a drug solution administration device that can accurately detect the amount of drug solution stored in the drug solution storage unit in consideration of the above problems.

In order to solve the above problems and achieve the object of the present invention, a liquid medicine administration device of the present invention is a liquid medicine storage unit, a pusher member, a pusher operation unit, a drive unit, a capacity measurement unit, a calculation unit. And are equipped with. The chemical liquid storage part is formed in a tubular shape and filled with the chemical liquid. The pusher member pushes out the drug solution filled in the drug solution storage unit. The pusher operating section operates the movement of the pusher member. The drive unit applies a driving force to the pusher operation unit. The capacity measuring unit has a plurality of electrodes arranged to face the outer wall of the chemical liquid storage unit. Then, the capacitance measuring unit measures the capacitance between the plurality of electrodes. The computing unit computes the amount of the drug solution filled in the drug solution storage unit from the capacitance measured by the capacitance measuring unit.

According to the drug solution administration device of the present invention, the amount of drug solution stored in the drug solution storage unit can be accurately detected.

It is a top view which shows the chemical|medical solution administration apparatus concerning the example of 1st Embodiment. It is sectional drawing which shows the capacity|capacitance measuring part and the chemical|medical solution storage part in the chemical|medical solution administration apparatus concerning 1st Embodiment. It is a block diagram which shows the control system of the chemical|medical solution administration apparatus concerning the example of 1st Embodiment. It is a flow chart which shows the 1st example of a medical fluid administration operation in the medical fluid administration device concerning a 1st embodiment. 8 is a flowchart showing a second example of the liquid medicine dispensing operation in the liquid medicine dispensing device according to the first embodiment. 7 is a flowchart showing a first example of an occlusion detection operation in the drug solution administration device according to the first embodiment. 9 is a flowchart showing a second example of the occlusion detection operation in the liquid medicine administration device according to the first embodiment. 9 is a flowchart showing a third example of the occlusion detection operation in the liquid medicine administration device according to the first embodiment. It is a top view which shows the chemical|medical solution administration apparatus concerning the example of 2nd Embodiment. It is a top view which shows the electrode of the capacitance measuring part of the chemical|medical solution administration apparatus concerning the example of 3rd Embodiment. It is a top view which shows the electrode of the capacitance measuring part of the chemical|medical solution administration apparatus concerning the example of 4th Embodiment.

Hereinafter, embodiments of the drug solution administration device of the present invention will be described with reference to FIGS. 1 to 11. In each figure, common members are designated by the same reference numerals. Moreover, the present invention is not limited to the following modes.

1. First Embodiment 1-1. Configuration of the chemical liquid administration device First, with reference to FIG. 1, a configuration example of the chemical liquid administration device according to the first embodiment (hereinafter referred to as “the present example”) will be described.
FIG. 1 is a plan view showing a drug solution administration device.

The device shown in FIG. 1 is a portable insulin pump such as a patch-type or tube-type insulin pump, and other portable drug-administration devices for continuously administering a drug solution to a patient's body. .. The drug solution administration device 1 includes a housing 11, a drug solution storage unit 13, a transmission mechanism 14, a driving unit 15, a power supply unit 17, a pusher member 18 for pushing out the drug solution filled in the drug solution storage unit 13, and a feeding unit. It has a liquid pipe 19, a rotation detecting unit 21, and a pusher operating unit 22 for operating the pusher member 18. The drug solution administration device 1 also includes a capacity measuring unit 31 that detects the amount of the drug solution in the drug solution storage unit 13, and a reference capacity measuring unit 32.

The housing 11 is formed in the shape of a hollow rectangular parallelepiped with one surface open. A lid (not shown) is attached to the housing 11 so as to close the opening of the housing 11. The housing 11 includes a drug solution storage unit 13, a transmission mechanism 14, a drive unit 15, a power supply unit 17, a pusher member 18, a liquid delivery pipe 19, a pusher operation unit 22, and a capacity measurement unit 31. Then, the reference capacity measuring unit 32 is housed. Further, when using the drug solution administration device 1, the connection port 6 is housed in the housing 11.

The chemical liquid storage portion 13 is formed in a tubular shape with one axial end closed and the other axial end opened. One end of the chemical liquid storage unit 13 in the axial direction is formed in a substantially flat shape. The inner diameter of the cylindrical hole 13c in the chemical liquid storage unit 13 is set to be the same size from the opened axial other end to the closed axial end. Therefore, the amount of the drug solution discharged from the drug solution storage unit 13 is discharged in a substantially constant amount. The drug solution is stored in the cylindrical hole 13c of the drug solution storage unit 13. A liquid feed port 13a and a filling port 13b are formed at one end of the chemical liquid storage unit 13 in the axial direction.

The liquid sending port 13 a is connected to the liquid sending pipe 19. The end of the liquid supply pipe 19 opposite to the liquid supply port 13 a is connected to the connection port 6. A cannula (not shown) is connected to the connection port 6, and the cannula is punctured and left in the living body of a patient. Then, the drug solution stored in the cylindrical hole 13c of the drug solution storage unit 13 is discharged from the solution sending port 13a, passes through the solution sending pipe 19 and the connection port 6, and is administered to the patient via the cannula.

A filling device (not shown) is connected to the filling port 13b. Then, the drug solution is filled into the cylindrical hole 13c of the drug solution storage unit 13 through the filling port 13b. Further, the drug solution storage unit 13 is provided with a capacity measuring unit 31 and a reference capacity measuring unit 32. The detailed configurations of the capacity measuring unit 31 and the reference capacity measuring unit 32 will be described later.

In addition, a pusher member 18 is slidably inserted into the cylindrical hole 13c of the drug solution storage unit 13. The pusher member 18 has a gasket 18a and a shaft portion 18b. The gasket 18a is slidably arranged in the cylindrical hole 13c of the chemical liquid storage unit 13. The gasket 18a moves in liquid tight contact with the inner peripheral surface of the cylindrical hole 13c of the chemical liquid storage unit 13.

The shape of the distal end portion of the gasket 18a is formed in a substantially flat shape corresponding to the shape of the axial end of the cylindrical hole 13c of the chemical liquid storage portion 13 in the axial direction. Thereby, when the gasket 18a moves to one end side in the axial direction of the chemical liquid storage unit 13, the chemical liquid filled in the chemical liquid storage unit 13 can be discharged from the liquid supply port 13a without waste.

A shaft portion 18b is provided on the side of the gasket 18a opposite to the tip portion. The shaft portion 18b extends outward from an opening formed at the other end of the chemical liquid storage portion 13 in the axial direction. A connecting portion 18c that engages with a connecting nut 22c of a pusher operating portion 22, which will be described later, is provided at an end of the shaft portion 18b opposite to the gasket 18a. When the connecting portion 18c is connected to the connecting nut 22c and the pusher operating portion 22 is driven, the pusher member 18 moves along the axial direction of the chemical liquid storage unit 13.

The pusher operating section 22 has an operating gear 22a, a feed screw shaft 22b, and a connecting nut 22c. The operation gear 22a meshes with a gear of the transmission mechanism 14 described later. The feed screw shaft 22b is connected to the rotary shaft of the operation gear 22a. The feed screw shaft 22b is rotatably supported by a bearing provided in the housing 11, and is arranged parallel to the shaft portion 18b.

A connecting nut 22c is screwed onto the feed screw shaft 22b. When the connection nut 22c is housed in the housing 11, rotation of the feed screw shaft 22b around the circumferential direction is restricted. As a result, when the operation gear 22a rotates and the feed screw shaft 22b rotates, the connection nut 22c moves along the axial direction of the feed screw shaft 22b. When the connecting portion 18c of the pusher member 18 is engaged with the connecting nut 22c, the pusher member 18 moves along with the connecting nut 22c in the axial direction of the feed screw shaft 22b. Further, the driving force of the driving unit 15 is transmitted to the pusher operating unit 22 via the transmission mechanism 14.

As the driving unit 15, for example, a stepping motor is applied. The drive unit 15 is connected to the electrode of the power supply unit 17 housed in the housing 11 and is supplied with electric power when the opening of the housing 11 is closed by the lid. The drive shaft 15a of the drive unit 15 is provided with a rotation detection unit 21 that detects the rotation of the drive shaft 15a.

The rotation detector 21 is a rotary encoder having a detection sensor 21a and a slit disk 21b. The slit disk 21b is fixed to the drive shaft 15a of the drive unit 15. The slit disk 21b rotates in synchronization with the rotation of the drive shaft 15a. Slits are formed at equal intervals on the peripheral edge of the slit disk 21b.

The detection sensor 21a is arranged in the housing 11. The detection sensor 21a is an optical sensor having a light emitting unit that emits light and a light receiving unit that receives the light emitted from the light emitting unit. The detection sensor 21a detects the rotation of the drive unit 15 by detecting the light transmitted through the slit of the slit disk 21b.

The drive shaft 15a of the drive unit 15 is provided with a gear of the transmission mechanism 14 described later. The transmission mechanism 14 transmits the driving force (rotation) of the drive unit 15 to the pusher operating unit 22. The transmission mechanism 14 is composed of a plurality of gears. When the drive unit 15 is driven, a plurality of gears forming the transmission mechanism 14 rotate, and the driving force of the drive unit 15 is transmitted to the operation gear 22a. Therefore, the pusher member 18 is operated, and the chemical solution stored in the chemical solution storage unit 13 is pushed out by the gasket 18a.

The power supply unit 17 is for supplying electric power to each constituent element of the chemical liquid administration device 1. The power supply unit 17 includes, for example, a battery 17a, a battery box that houses the battery 17a, and a switch that turns on/off the power supply from the battery.

[Capacity measuring unit]
Next, the capacitance measuring unit 31 will be described with reference to FIGS. 1 and 2.
FIG. 2 is a cross-sectional view showing the capacity measuring unit 31 and the chemical liquid storage unit 13.

The capacitance measuring section 31 has a first electrode 31a and a second electrode 31b. As shown in FIG. 2, the first electrode 31 a and the second electrode 31 b are arranged to face the outer wall portion of the chemical liquid storage unit 13. The first electrode 31a and the second electrode 31b are formed in a substantially rectangular flat plate shape. Then, as shown in FIG. 1, the first electrode 31 a and the second electrode 31 b are arranged such that their longitudinal directions are substantially parallel to the axial direction of the chemical liquid storage unit 13.

In addition, as shown in FIGS. 1 and 2, the first electrode 31a and the second electrode 31b are orthogonal to the axial direction of the chemical solution storage unit 13 and are also orthogonal to the direction facing the chemical solution storage unit 13, that is, the chemical solution. The storage portions 13 are arranged at intervals in the width direction. Then, the capacitance measuring unit 31 measures the capacitance between the first electrode 31a and the second electrode 31b. Since the size and interval of the first electrode 31a and the second electrode 31b are constant, the capacitance between the first electrode 31a and the second electrode 31b is stored in the cylindrical hole 13c of the chemical liquid storage unit 13. It changes depending on the amount of drug solution.

Further, since the dielectric constant of the chemical liquid is larger than that of air, for example, when the chemical liquid is filled in the cylindrical hole 13c of the chemical liquid storage unit 13, the static electricity between the first electrode 31a and the second electrode 31b is reduced. The electric capacity increases. On the other hand, when the cylindrical solution 13c of the chemical solution storage unit 13 is not filled with the chemical solution, the capacitance between the first electrode 31a and the second electrode 31b decreases. As described above, by measuring the capacitance between the first electrode 31a and the second electrode 31b, it is possible to accurately detect the amount of the drug solution filled in the cylindrical hole 13c of the drug solution storage unit 13.

As described above, the axial end of the chemical liquid storage part 13 and the tip of the gasket 18a are formed in a substantially flat shape, and the inner diameter of the cylindrical hole 13c of the chemical liquid storage part 13 is from the axial end. The size is set to the other end. Therefore, regardless of the position of the gasket 18a in the cylindrical hole 13c, a substantially constant amount of the chemical liquid is discharged from the chemical liquid storage unit 13 for a predetermined movement amount of the gasket 18a. Further, the outer wall surface of the drug solution storage unit 13 where the first electrode 31a and the second electrode 31b face each other is formed in a flat plate shape, and the distance between the drug solution storage unit 13 and the first electrode 31a and the second electrode 31b is the drug solution. The length is always set to be the same along the axial direction of the storage unit 13.

Thereby, the change in the amount of the chemical solution stored in the chemical solution storage unit 13 and the change in the electrostatic capacitance between the first electrode 31a and the second electrode 31b can be made proportional. As a result, it is possible to easily perform the measurement process of the amount of the drug solution stored in the drug solution storage unit 13.

Further, a shield member may be arranged on the opposite side of the first electrode 31a and the second electrode 31b of the capacitance measuring section 31 from the surface facing the chemical liquid storage section 13. As the material of the shield member, a material that does not affect the capacitance between the first electrode 31a and the second electrode 31b is used. As a result, it is possible to prevent the capacitance between the first electrode 31a and the second electrode 31b from changing due to external noise other than the change in the amount of the chemical liquid in the chemical liquid storage unit 13. As a result, it is possible to improve the accuracy of the measurement of the amount of the drug solution stored in the drug solution storage unit 13 by the capacity measuring unit 31.

[Reference capacity measurement part]
Next, the reference capacity measuring unit 32 will be described.
The reference capacitance measuring unit 32 has a first reference electrode 32a and a second reference electrode 32b. The first reference electrode 32a and the second reference electrode 32b are provided to face the liquid delivery port 13a of the chemical liquid storage unit 13. The first reference electrode 32a and the second reference electrode 32b are arranged at a distance from each other.

Here, since the liquid feed port 13a is formed of a hard material, the volume of the liquid feed port 13a is known. Further, when using the drug solution administration device 1, the liquid feed port 13a is filled with the drug solution. Then, while the drug solution administration device 1 is used, the amount of the drug solution stored in the liquid feed port 13a is always a constant amount. Therefore, since the amount of the chemical solution stored in the liquid supply port 13a does not change, the capacitance between the first reference electrode 32a and the second reference electrode 32b changes only due to the disturbance such as the temperature of the chemical solution.

In this example, the first reference electrode 32a and the second reference electrode 32b of the reference capacity measuring unit 32 are provided in the liquid delivery port 13a of the chemical liquid storage unit 13, but the present invention is not limited to this. .. For example, it is possible to provide the housing 11 with a reference capacitance section in which the chemical liquid is stored in advance without changing the volume, and to provide the first reference electrode 32a and the second reference electrode 32b in this reference capacitance section.

Also in the reference capacity measuring unit 32, like the capacity measuring unit 31, a shield member may be arranged on the side opposite to the surface of the first reference electrode 32a and the second reference electrode 32b facing the liquid delivery port 13a. ..

1-2. Control System of Chemical Solution Administration Device Next, a control system of the chemical solution administration apparatus 1 showing an example of the chemical solution administration apparatus will be described with reference to FIG.
FIG. 3 is a block diagram showing a control system of the drug solution administration device 1.

As shown in FIG. 3, the drug solution administration device 1 includes the drive unit 15, the rotation detection unit 21, the capacity measurement unit 31, the reference capacity measurement unit 32, and the power supply unit 17 described above. In addition, the drug solution administration device 1 includes a calculation unit 101, an output unit 102, a communication unit 103, a storage unit 104, a date/time management unit 105, an operation unit 106, and a display unit 107.

The drive unit 15, the rotation detection unit 21, the capacity measurement unit 31, the reference capacity measurement unit 32, the power supply unit 17, the output unit 102, the communication unit 103, the storage unit 104, the date and time management unit 105, The operation unit 106 and the display unit 107 are connected to the calculation unit 101.

The rotation information of the drive unit 15 detected by the detection sensor 21a (see FIG. 1) of the rotation detection unit 21 is output to the calculation unit 101. The driving of the driving unit 15 is controlled by the arithmetic unit 101.

The capacitance measuring unit 31 measures the capacitance between the first electrode 31a and the second electrode 31b. Then, the capacitance measuring unit 31 outputs the measured capacitance information to the arithmetic unit 101. The reference capacitance measuring unit 32 measures the reference capacitance between the first reference electrode 32a and the second reference electrode 32b (see FIG. 1). Then, the reference capacitance measuring unit 32 outputs the measured reference capacitance information to the arithmetic unit 101. The calculation unit 101 controls the timing of capacitance measurement in the capacitance measuring unit 31 and the reference capacitance measuring unit 32.

The operation unit 106 performs on/off operation of the power supply unit 17, operation setting of the drive unit 15, selection of display content displayed on the display unit 107, and the like. Further, the user can operate the operation unit 106 to input the administration pattern for administering the drug solution into the storage unit 104, the arithmetic unit 101, or the like.

The display unit 107 showing an example of the notification unit displays the setting of the administration pattern for administering the liquid medicine set by the operation unit 106, the input content input by the operation unit 106, and the like. In addition, the display unit 107 displays the blockage information and the information regarding the amount of the drug solution stored in the drug solution storage unit 13. A display example displayed on the display unit 107 will be described later. A liquid crystal display, an organic EL display, or the like is used as the display unit 107.

The output unit 102, which is an example of the notification unit, is driven by an instruction from the calculation unit 101 and outputs an alarm when a malfunction occurs in the drug solution administration device 1 or when occlusion is detected. As the alarm output by the output unit 102, for example, vibration or sound may be issued alone, or vibration or sound may be used in combination. Further, when the output unit 102 outputs an alarm, the content of the alarm may be displayed on the display unit 107.

The communication unit 103 is connected to a controller (not shown) that operates the drug solution administration device 1, an external portable information processing terminal, or a PC (personal computer) via a wired or wireless network. The communication unit 103 receives operation information operated by a user via a controller (not illustrated), a mobile information processing terminal, or the like, and measurement data measured by an external device. Then, the communication unit 103 outputs the received operation information and measurement data to the calculation unit 101.

In addition, the communication unit 103 is controlled by the calculation unit 101, so that the occlusion information, the information about the amount of the drug solution stored in the drug solution storage unit 13, and the various information about the drug solution administration device 1 such as the administration pattern are not shown. Output to the controller, mobile information processing terminal, etc.

The storage unit 104 is a unit that stores various data. The storage unit 104 stores a dosing profile indicating a dosing pattern for dosing a liquid medicine, a control program for controlling the volume measuring unit 31, and the like, threshold value data used for blockage detection, and the amount of the starting liquid medicine. Further, the storage unit 104 stores information received by the communication unit 103, capacitance information measured by the capacitance measurement unit 31, reference capacitance information measured by the reference capacitance measurement unit 32, and the like. Then, the storage unit 104 outputs the control program stored in advance, the capacitance information received from other processing units, and the like to the calculation unit 101.

The date/time management unit 105 is a program portion for performing date/time management, and may be one installed in a general microcomputer, and outputs date/time information based on a command from the calculation unit 101. The date and time management unit 105 outputs accurate date and time information by being supplied with power even when the power is off.

A program that controls various devices such as the driving unit 15, the capacity measuring unit 31, the reference capacity measuring unit 32, the communication unit 103, the storage unit 104, and the date/time management unit 105 is installed in the arithmetic unit 101. Then, the calculation unit 101 controls various operations of the drug solution administration device 1 based on the program. Further, the calculation unit 101 receives the rotation information of the drive unit 15 detected by the rotation detection unit 21, the capacitance information measured by the capacitance measuring unit 31, the reference capacitance information measured by the reference capacitance measuring unit 32, and the like. To do. The arithmetic unit 101 stores the received information in the storage unit 104.

Further, the calculation unit 101 calculates the amount of the chemical liquid stored in the chemical liquid storage unit 13 based on the received electrostatic capacitance information and the reference electrostatic capacitance information, and determines whether or not the channel of the chemical liquid is blocked. To do

Further, the calculation unit 101 drives the drive unit 15 based on the administration profile that indicates the administration pattern of the drug solution stored in the storage unit 104. As a result, the user is administered the drug solution based on the predetermined administration profile. The arithmetic unit 101 includes, for example, a CPU (Central Processing Unit), a RAM (Random Access Memory), and a ROM (Read Only Memory), which are not shown here. The ROM (Read Only Memory) may be the storage unit 104.

1-3. Operation of the chemical liquid administration device Next, the operation of the chemical liquid administration device 1, which is the chemical liquid administration device having the configuration described above, will be described with reference to FIGS. 4 to 8. 4 and 5 show the operation of the liquid medicine administration device 1 during the liquid medicine administration, and FIGS. 6 to 8 show the blockage detection operation of the liquid medicine administration device 1 during the liquid medicine administration.

[First example of liquid medicine administration operation]
First, a first example of the liquid medicine dispensing operation of the liquid medicine dispenser 1 will be described with reference to FIG.
FIG. 4 is a flowchart showing a first example of the drug solution administration operation.

As shown in FIG. 4, the calculation unit 101 controls the capacitance measuring unit 31 to calculate the pre-administration capacitance (pre-administration capacitance) C1 between the first electrode 31a and the second electrode 31b before administering the drug solution. Measure (step S11). Then, the capacitance measuring unit 31 outputs information on the measured pre-dose capacitance C1 to the arithmetic unit 101. The calculation unit 101 calculates the amount of the drug solution stored in the drug solution storage unit 13 from the pre-administration capacitance C1.

Next, the calculation unit 101 determines whether the received pre-administration capacitance C1 is greater than or equal to the pre-administration threshold A (step S12). The pre-administration threshold value A is stored in the storage unit 104 in advance. As the pre-administration threshold value A, a capacitance corresponding to the maximum amount of the liquid medicine administered from the liquid medicine administration device 1 during the expected use period is set. When the pre-dose capacitance C1 between the first electrode 31a and the second electrode 31b is greater than or equal to the pre-dose threshold A, the cylindrical hole 13c of the drug solution storage unit 13 is sufficiently filled with the drug solution at the time of starting the drug administration. It can be judged that it has been done.

Therefore, in the process of step S12, when the calculation unit 101 determines that the pre-administration capacitance C1 is equal to or more than the pre-administration threshold value A (YES determination in step S12), the calculation unit 101 starts the drug solution administration operation ( Step S13). Specifically, the calculation unit 101 drives the drive unit 15 to operate the pusher member 18 to start the liquid medicine administration operation.

In addition, as the administration operation of the drug solution performed in the process of step S13, for example, a basal administration in which a fixed amount of the drug solution is continuously administered to the user over a day (24 hours), so-called basal administration is performed.

On the other hand, when the pre-administration capacitance C1 is smaller than the pre-administration threshold value A, it can be determined that the amount of the drug solution necessary for starting the administration is insufficient in the cylindrical hole 13c of the drug solution storage unit 13. .. Therefore, in the process of step S12, when the arithmetic unit 101 determines that the pre-administration capacitance C1 is smaller than the pre-administration threshold value A (NO determination in step S12), the arithmetic unit 101 outputs the output unit 102 and the display unit 107. Is controlled to output a starting drug solution shortage alarm indicating that the amount of drug solution necessary for starting administration is insufficient (step S16). Thereby, the patient or the user is notified that the amount of the drug solution stored in the drug solution storage unit 13 is insufficient.

In the process of step S13, when the drug solution administration operation is started, the calculation unit 101 controls the capacitance measuring unit 31 to administer the capacitance during administration between the first electrode 31a and the second electrode 31b (capacity during administration). ) C2 is measured (step S14). Then, the capacitance measuring unit 31 outputs information on the measured capacitance C2 during administration to the arithmetic unit 101. The calculation unit 101 calculates the amount of the drug solution stored in the drug solution storage unit 13 from the capacitance C2 during administration.

Next, the calculation unit 101 determines whether or not the received capacitance C2 during administration is greater than or equal to the threshold B during administration (step S15). The threshold value B during administration used in the process of step S15 is set to a value smaller than the pre-administration threshold value A used in the process of step S12 (A>B). The administration threshold B is stored in the storage unit 104 in advance, like the pre-administration threshold A. As the threshold value B at the time of administration, the electrostatic capacity corresponding to a state in which the liquid medicine does not remain in the liquid medicine storage unit 13 or the electrostatic capacity corresponding to the amount of the liquid medicine necessary for administration can be determined to be insufficient. Is set to.

In the process of step S15, when the calculation unit 101 determines that the capacitance C2 during administration is equal to or more than the threshold value B during administration (YES determination in step S15), the calculation unit 101 returns to the process before step S14 and administers the medicinal solution. Let the operation continue. That is, it is determined that the drug solution still remains in the drug solution storage unit 13.

On the other hand, when the capacitance C2 during administration is smaller than the threshold B during administration, it can be determined that the drug solution does not remain in the drug solution storage unit 13 or the amount of the drug solution required for administration is insufficient. Therefore, in the process of step S15, when the arithmetic unit 101 determines that the capacitance C2 during administration is smaller than the threshold B during administration (NO determination in step S15), the arithmetic unit 101 stops driving the drive unit 15. Then, the drug solution administration operation is terminated (step S17). Further, in the process of step S17, the calculation unit 101 may control the output unit 102 and the display unit 107 to notify the user that the drug solution administration operation has ended. As a result, the liquid medicine dispensing operation of the liquid medicine dispenser 1 is completed.

The capacitance measuring process at the time of administration in step S14 may be performed constantly while the drug solution administration operation is performed, or may be performed at predetermined time intervals. Further, in the processing of step S11 and the processing of step S14, an example in which the calculation unit 101 calculates the amount of the chemical liquid stored in the chemical liquid storage unit 13 from the capacitance has been described, but the present invention is not limited to this. The calculation unit 101 does not have to calculate the amount of the chemical liquid stored in the chemical liquid storage unit 13 from the capacitance.

[Second example of liquid medicine administration operation]
Next, a second example of the liquid medicine dispensing operation of the liquid medicine dispenser 1 will be described with reference to FIG.
FIG. 5 is a flowchart showing a second example of the drug solution administration operation.

In the second example of the liquid medicine dispensing operation shown in FIG. 5, an example using the reference volume measuring unit 32 will be described. As shown in FIG. 5, first, the arithmetic unit 101 controls the capacitance measuring unit 31 to measure the pre-administration capacitance (pre-administration capacitance) between the first electrode 31a and the second electrode 31b before administering the drug solution. C1 is measured (step S21). Then, the capacitance measuring unit 31 outputs information on the measured pre-dose capacitance C1 to the arithmetic unit 101.

Next, the calculation unit 101 controls the reference capacitance measuring unit 32 to calculate the reference capacitance (pre-administration reference capacitance) Cref ₁ between the first reference electrode 32a and the second reference electrode 32b before administering the drug solution. Measure (step S22). Then, the reference capacitance measuring unit 32 outputs information regarding the measured reference capacitance Cref ₁ to the arithmetic unit 101. As described above, the reference volume measuring unit 32 is provided in the liquid delivery port 13a having a known volume and always containing the chemical liquid. Then, the amount of the chemical liquid stored in the liquid supply port 13a does not change. In addition, the storage unit 104 stores in advance information regarding the volume of the liquid delivery port 13a in which the reference volume measuring unit 32 is provided. Therefore, it is possible to correlate the change in the electrostatic capacitance due to the disturbance such as the temperature of the chemical liquid with the amount of the chemical liquid.

Then, the calculation unit 101 multiplies the pre-administration threshold value K1 by the received reference capacitance Cref ₁ (K1×Cref ₁ ). For example, assuming that the capacitance has a proportional relationship with the temperature of the drug solution, the pre-administration threshold value K1 is the maximum amount of the drug solution administered from the drug solution administration device 1 during the expected use period, and the delivery port 13a. The value divided by the volume of is set. That is, it is possible to calculate the threshold value in consideration of the reference capacitance Cref ₁ to the pre-administration threshold value K1 and match the pre-administration capacitance C1 measured in the process of step S21 with the threshold temperature and other conditions. As a result, it becomes possible to more accurately measure the amount of the drug solution filled in the drug solution storage unit 13.

Next, the calculation unit 101 determines whether or not the pre-administration capacitance C1 is equal to or larger than a threshold value in consideration of the reference capacitance Cref ₁ (step S23). In the processing of step S23, if the pre-administration capacitance C1 is calculating unit 101 to be greater than the threshold value in consideration of the reference capacitance Cref ₁ is determined (YES determination at step S23), calculation unit 101, a chemical solution dispensing operation Is started (step S24).

On the other hand, in the process of step S23, when the calculation unit 101 determines that the pre-dose capacitance C1 is smaller than the threshold value considering the reference capacitance Cref ₁ (NO determination in step S23), the calculation unit 101 Then, the output unit 102 and the display unit 107 are controlled to output the starting chemical liquid amount insufficient alarm (step S28).

In the process of step S24, when the liquid medicine administration operation is started, the calculation unit 101 controls the capacitance measuring unit 31 to administer the capacitance during administration between the first electrode 31a and the second electrode 31b (capacity during administration). ) C2 is measured (step S25). Then, the capacitance measuring unit 31 outputs information on the measured capacitance C2 during administration to the arithmetic unit 101.

In addition, in the process of step S25, when the capacitance C2 during administration of the capacitance measuring unit 31 is measured, the arithmetic unit 101 controls the reference capacitance measuring unit 32 so that the first reference electrode 32a at the time of administration of the drug solution is provided. The reference capacitance (reference capacitance during administration) Cref ₂ between the second reference electrodes 32b is measured (step S26). Then, the reference capacitance measuring unit 32 outputs information regarding the measured reference capacitance Cref ₂ to the arithmetic unit 101. The arithmetic unit 101 multiplies the reference capacitance Cref ₂ received the administration time threshold K2 (K2 × Cref _2). For example, if the capacitance is proportional to the temperature of the liquid medicine, the amount of liquid medicine required for administration may be determined to be insufficient for the administration threshold K2. The value divided by is set. That is, a threshold value in consideration of the reference electrostatic capacity Cref ₂ is calculated as the administration threshold value K2, and the conditions such as the administration electrostatic capacity C2 measured in the process of step S25 and the threshold temperature are matched.

Next, the calculation unit 101 determines whether a threshold or more administration at the capacitance C2 is considering reference capacitance Cref ₂ (step S27). In the process of step S27, when the calculation unit 101 determines that the capacitance C2 during administration is equal to or greater than the threshold value in consideration of the reference capacitance Cref ₂ (YES determination in step S27), the calculation unit 101 determines that the process in step S25 is performed. The returning chemical solution administration operation is continued until before the processing.

On the other hand, in the process of step S27, when the calculation unit 101 determines that the capacitance C2 during administration is smaller than the threshold value that takes the reference capacitance Cref ₂ into consideration (NO determination in step S27), the calculation unit 101 Then, the drive of the drive unit 15 is stopped, and the drug solution administration operation is ended (step S29). Further, in the process of step S29, the calculation unit 101 may control the output unit 102 and the display unit 107 to notify the user that the drug solution administration operation has ended. As a result, the liquid medicine dispensing operation of the liquid medicine dispenser 1 is completed.

In the administration operation according to the second example shown in FIG. 5, the reference capacitance measuring unit 32 measures the reference capacitance when the capacitance measuring unit 31 measures the capacitance. Then, the threshold value is calculated in consideration of the reference capacitance. Thereby, the capacitance measured by the capacitance measuring unit 31 and the disturbance condition such as the threshold temperature can be matched, and the accuracy of measuring the amount of the chemical liquid stored in the chemical liquid storage unit 13 can be improved.

[First example of blockage detection operation]
Next, a first example of the blockage detecting operation will be described with reference to FIG.
FIG. 6 is a flowchart showing a first example of a blockage detecting operation during liquid feeding.

As shown in FIG. 6, the calculation unit 101 controls the capacitance measuring unit 31 at a predetermined timing to measure the capacitance C0 between the first electrode 31a and the second electrode 31b for the first time. (Step S31). Then, the capacitance measuring unit 31 outputs information regarding the measured first electrostatic capacitance C0 to the arithmetic unit 101. The calculation unit 101 stores the received first capacitance C0 in the storage unit 104.

Next, the arithmetic part 101 determines whether or not the amount of the chemical liquid delivered from the chemical liquid storage part 13 has reached the first liquid delivery amount N1 based on the drive control of the drive part 15 (step S32).

In the process of step S32, when the calculation unit 101 determines that the first liquid delivery amount N1 has been sent out based on the drive control of the drive unit 15 (YES determination in step S32), the calculation unit 101 causes the capacity measurement unit 31 to operate. It controls and measures the electrostatic capacitance (capacitance) C1 between the 1st electrode 31a and the 2nd electrode 31b of the 2nd time (step S33). Then, the capacitance measuring unit 31 outputs information on the measured second capacitance C1 to the arithmetic unit 101. The calculation unit 101 stores the received second capacitance C1 in the storage unit 104.

Next, the calculation unit 101 determines whether or not the amount of the chemical liquid delivered from the chemical liquid storage unit 13 has reached the second liquid delivery amount N2, based on the drive control of the drive unit 15 (step S34). The second liquid feed amount N2 is set to be E times the first liquid feed amount N1 (E is an integer).

Note that the chemical liquid may be sent out continuously from the process of step S32. In this case, in the process of step S34, the calculation unit 101 determines whether or not the amount of the chemical liquid after delivering the first liquid delivery amount N1 has reached the second liquid delivery amount N2.

In the process of step S34, when the calculation unit 101 determines that the second liquid delivery amount N2 has been sent out based on the drive control of the drive unit 15 (YES determination in step S34), the calculation unit 101 causes the capacity measurement unit 31 to operate. It controls and measures the electrostatic capacitance (capacitance) C2 between the 1st electrode 31a and the 2nd electrode 31b of the 3rd time (step S35). Then, the capacitance measuring unit 31 outputs information on the measured capacitance C2 of the third time to the arithmetic unit 101. The calculation unit 101 stores the received third capacitance C2 in the storage unit 104.

Next, the calculation unit 101 calculates the ratio of the difference between the capacitance C2 of the third time and the capacitance C1 of the second time and the difference between the capacitance C1 of the second time and the capacitance C0 of the first time ( C1-C2/C0-C1). That is, the calculation unit 101 uses the information about the capacitance measured by the capacitance measuring unit 31 to calculate the ratio of the liquid feed amount based on the first measured value and the liquid feed amount based on the second measured value. ..

Next, the calculation unit 101 determines whether or not the ratio C1-C2/C0-C1 of the liquid transfer amount based on the actual measurement value is smaller than the threshold value (step S36). As the threshold value used in the process of step S36, the blockage detection coefficient t is multiplied by the ratio E of the first and second liquid feed amounts (the ratio of the first liquid feed amount N1 and the second liquid feed amount N2) E based on the theoretical value. It is a thing. The occlusion detection coefficient t takes into consideration an error in the amount of the chemical solution sent by driving the drive unit 15, the transmission mechanism 14, and the pusher operation unit 22, and is set to 1 or less.

When the ratio C1-C2/C0-C1 of the liquid transfer amount based on the measured value is smaller than the ratio of the liquid transfer amount based on the theoretical value, it is considered that the flow path of the chemical liquid is clogged. Therefore, in step S36, when the calculation unit 101 determines that the ratio C1-C2/C0-C1 of the liquid delivery amount based on the actual measurement value is smaller than the threshold value (YES determination in step 36), the calculation unit 101 determines that the chemical liquid It is determined that the flow path is clogged. Then, the arithmetic unit 101 controls the output unit 102 and the display unit 107 to output a blockage alarm for notifying the user of the blockage (step S37). As a result, the blockage detection operation of the chemical liquid administration device 1 ends.

In addition, in step S36, when the calculation unit 101 determines that the ratio C1-C2/C0-C1 of the liquid transfer amount based on the actual measurement value is not smaller than the threshold value (NO determination in step 36), the calculation unit 101 determines that the chemical liquid is used. It is determined that the flow path is not blocked. Then, the calculation unit 101 ends the blockage detection operation. As a result, the blockage detection operation of the chemical liquid administration device 1 ends.

This occlusion detection operation may be performed during the chemical solution administration operation shown in FIGS. 4 and 5, or may be performed before the chemical solution administration operation. Further, when the blockage detecting operation is continuously performed after the process of step S36, the process returns to the process of step S31 or step S33. The capacitance stored in the storage unit 104 is updated to the latest capacitance value each time the capacitance measuring unit 31 measures the capacitance between the first electrode 31a and the second electrode 31b. It

[Second example of blockage detection operation]
Next, a second example of the blockage detecting operation will be described with reference to FIG.
FIG. 7 is a flowchart showing a second example of the blockage detection operation during liquid transfer.

As illustrated in FIG. 7, the calculation unit 101 controls the capacitance measuring unit 31 at a predetermined timing to measure the capacitance C0 between the first electrode 31a and the second electrode 31b for the first time. (Step S41). Then, the capacitance measuring unit 31 outputs information regarding the measured first electrostatic capacitance C0 to the arithmetic unit 101. The calculation unit 101 stores the received first capacitance C0 in the storage unit 104.

Next, the calculation unit 101 determines whether the rotation speed of the drive unit 15 has reached the first rotation speed M1 based on the information from the rotation detection unit 21 (step S42). It should be noted that the rotation speed of the drive unit 15 and the amount of the chemical solution delivered from the chemical solution storage unit 13 are proportional to each other. Therefore, when the drive unit 15 rotates a predetermined number of times, a predetermined amount of chemical liquid is delivered from the chemical liquid storage unit 13.

In the process of step S42, when the calculation unit 101 determines that the rotation speed of the drive unit 15 has reached the first rotation speed M1 based on the information from the rotation detection unit 21 (YES determination in step S42), the calculation unit. 101 controls the capacitance measuring unit 31 to measure the capacitance C1 between the first electrode 31a and the second electrode 31b for the second time (step S43). Then, the capacitance measuring unit 31 outputs information on the measured second capacitance C1 to the arithmetic unit 101. The calculation unit 101 stores the received second capacitance C1 in the storage unit 104.

Next, the calculation unit 101 determines, based on the information from the rotation detection unit 21, that the rotation speed of the drive unit 15 is the second rotation speed M2 after the process of step S42, that is, after the first rotation speed M1 is reached. It is determined whether or not has reached (step S44). The second rotation speed M2 is set to F times the first rotation speed M1 (F is an integer).

In the process of step S44, when the calculation unit 101 determines that the rotation speed of the drive unit 15 has reached the second rotation speed M2 based on the information from the rotation detection unit 21 (YES determination in step S44), the calculation unit 101. Controls the capacitance measuring unit 31 to measure the capacitance (capacitance) C2 between the first electrode 31a and the second electrode 31b for the third time (step S45). Then, the capacitance measuring unit 31 outputs information on the measured capacitance C2 of the third time to the arithmetic unit 101. The calculation unit 101 stores the received third capacitance C2 in the storage unit 104.

Next, the calculation unit 101 calculates the ratio of the difference between the capacitance C2 of the third time and the capacitance C1 of the second time and the difference between the capacitance C1 of the second time and the capacitance C0 of the first time ( C1-C2/C0-C1). That is, the calculation unit 101 uses the information about the capacitance measured by the capacitance measuring unit 31 to calculate the ratio of the liquid feed amount based on the first measured value and the liquid feed amount based on the second measured value. ..

Next, the calculation unit 101 determines whether or not the ratio C1-C2/C0-C1 of the liquid transfer amount is smaller than the threshold value (step S46). The threshold used in the process of step S46 is the ratio F of the first rotation speed M1 and the second rotation speed M2 multiplied by the blockage detection coefficient t.

When the ratio C1-C2/C0-C1 of the liquid delivery amount based on the actual measurement value is smaller than the ratio of the rotation speed of the drive unit 15, it is considered that the flow path of the chemical liquid is clogged. Therefore, in step S46, when the calculation unit 101 determines that the ratio C1-C2/C0-C1 of the liquid delivery amount based on the actual measurement value is smaller than the threshold value (YES determination in step 46), the calculation unit 101 determines that the chemical liquid It is determined that the flow path is clogged. Then, the arithmetic unit 101 controls the output unit 102 and the display unit 107 to output a blockage alarm (step S47). As a result, the blockage detection operation of the chemical liquid administration device 1 ends.

In addition, in step S46, when the calculation unit 101 determines that the ratio C1-C2/C0-C1 of the liquid delivery amount based on the actual measurement value is not smaller than the threshold value (NO determination in step 46), the calculation unit 101 determines that the chemical liquid is used. It is determined that the flow path is not blocked. Then, the calculation unit 101 ends the blockage detection operation. As a result, the blockage detection operation of the chemical liquid administration device 1 ends.

[Third example of blockage detection operation]
Next, a third example of the blockage detection operation will be described with reference to FIG.
FIG. 8 is a flow chart showing a third example of the occlusion detection operation during constant-flow liquid delivery, for example, in basal administration.

As shown in FIG. 8, the calculation unit 101 controls the capacitance measuring unit 31 at a predetermined timing to measure the capacitance C0 between the first electrode 31a and the second electrode 31b for the first time. (Step S51). Then, the capacitance measuring unit 31 outputs information regarding the measured first electrostatic capacitance C0 to the arithmetic unit 101. The calculation unit 101 stores the received first capacitance C0 in the storage unit 104.

Next, the calculation unit 101 determines whether the drive time of the drive unit 15 has reached the first administration time T1 (step S52). The drive time of the drive unit 15 and the amount of the chemical liquid delivered from the chemical liquid storage unit 13 are proportional to each other. Therefore, when the drive unit 15 is driven for a predetermined time, a predetermined amount of chemical liquid is delivered from the chemical liquid storage unit 13.

In the process of step S52, when the calculation unit 101 determines that the drive time of the drive unit 15 has reached the first administration time T1 based on the information from the date/time management unit 105 (YES determination in step S52), the calculation unit 101. Controls the capacitance measuring unit 31 to measure the electrostatic capacitance (capacitance) C1 between the first electrode 31a and the second electrode 31b for the second time (step S53). Then, the capacitance measuring unit 31 outputs information on the measured second capacitance C1 to the arithmetic unit 101. The calculation unit 101 stores the received second capacitance C1 in the storage unit 104.

Next, the arithmetic part 101 determines whether or not the drive time of the drive part 15 has reached the second administration time T2 after the process of step S53, that is, after the first administration time T1 has been reached (step). S54). The second administration time T2 is set to G times the first administration time T1 (G is an integer).

In the process of step S54, when the calculation unit 101 determines that the drive time of the drive unit 15 has reached the second administration time T2 based on the information from the date/time management unit 105 (YES determination in step S54), the calculation unit 101. Controls the capacitance measuring unit 31 to measure the electrostatic capacitance (capacitance) C2 between the first electrode 31a and the second electrode 31b for the third time (step S55). Then, the capacitance measuring unit 31 outputs information on the measured capacitance C2 of the third time to the arithmetic unit 101. The calculation unit 101 stores the received third capacitance C2 in the storage unit 104.

Next, the calculation unit 101 calculates the ratio of the difference between the capacitance C2 of the third time and the capacitance C1 of the second time and the difference between the capacitance C1 of the second time and the capacitance C0 of the first time ( C1-C2/C0-C1). That is, the calculation unit 101 uses the information about the capacitance measured by the capacitance measuring unit 31 to calculate the ratio of the liquid feed amount based on the first measured value and the liquid feed amount based on the second measured value. ..

Next, the calculation unit 101 determines whether or not the ratio C1-C2/C0-C1 of the liquid transfer amount based on the actual measurement value is smaller than the threshold value (step S56). The threshold used in the process of step S56 is the ratio G of the first administration time T1 and the second administration time T2 multiplied by the occlusion detection coefficient t.

When the ratio C1-C2/C0-C1 of the liquid delivery amount based on the actual measurement value is smaller than the ratio of the drive time of the drive unit 15, it is considered that the flow path of the chemical liquid is clogged. Therefore, in step S56, when the calculation unit 101 determines that the ratio C1-C2/C0-C1 of the liquid delivery amount based on the actual measurement value is smaller than the threshold value (YES determination in step 56), the calculation unit 101 determines that the chemical liquid It is determined that the flow path is clogged. Then, the arithmetic unit 101 controls the output unit 102 and the display unit 107 to output a blockage alarm (step S57). As a result, the blockage detection operation of the chemical liquid administration device 1 ends.

In addition, in step S56, when the calculation unit 101 determines that the ratio C1-C2/C0-C1 of the liquid delivery amount based on the actual measurement value is not smaller than the threshold value (NO determination in step 56), the calculation unit 101 determines that the chemical liquid is used. It is determined that the flow path is not blocked. Then, the calculation unit 101 ends the blockage detection operation. As a result, the blockage detection operation of the chemical liquid administration device 1 ends.

As described above, the occlusion detection operation of the chemical liquid administration device 1 of the present example is a predetermined amount (theoretical value) instructed by the calculation unit 101 to the drive unit 15 and an operation of delivering a predetermined amount of chemical liquid in accordance with the instruction of the calculation unit 101. It is performed by comparing the capacitance (actually measured value) measured before and after. Further, as information output to the drive unit 15 in order for the arithmetic unit 101 to deliver a predetermined amount of chemical liquid, as in the operation example shown in FIGS. 7 and 8, the rotation speed of the drive unit 15 and the drive unit 15 Drive time may be set.

2. Second Embodiment Example Next, a drug solution administration device according to a second embodiment example will be described with reference to FIG. 9.
FIG. 9 is a plan view showing a drug solution administration device 51 according to the second embodiment.

The medicinal-solution administration device 51 according to the second embodiment differs from the medicinal-solution administration device 1 according to the first embodiment in the configuration of the electrodes of the capacitance measuring unit. Therefore, the volume measuring unit will be mainly described here, and portions common to the drug solution administration device 1 according to the first embodiment will be denoted by the same reference numerals and redundant description will be omitted.

As shown in FIG. 9, the drug solution administration device 51 includes a capacity measuring unit 61 provided in the drug solution storage unit 13. The capacity measuring unit 61 is arranged to face the outer wall of the chemical liquid storage unit 13. The capacitance measuring unit 61 has four electrodes 61a, 61b, 61c, 61d. The number of electrodes is not limited to four, and may be three or less, or five or more.

The four electrodes 61a, 61b, 61c, 61d are formed in a substantially rectangular flat plate shape. Further, the four electrodes 61a, 61b, 61c, 61d are arranged at predetermined intervals along the axial direction of the chemical liquid storage unit 13.

The first electrode 61a is arranged at one end of the chemical liquid storage unit 13 in the axial direction. The second electrode 61b is arranged on the other end side of the first electrode 61a and the third electrode 61c in the axial direction of the chemical liquid storage unit 13 and at the other end side of the chemical liquid storage unit 13 in the axial direction of the first electrode 61a. There is. The third electrode 61c is spaced apart from the second electrode 61b and the fourth electrode 61d in the axial direction of the chemical liquid storage unit 13, and is disposed on the other end side of the chemical liquid storage unit 13 in the axial direction of the second electrode 61b. There is. The fourth electrode 61d is spaced from the third electrode 61c in the axial direction of the chemical liquid storage unit 13, and is axially the other end side of the chemical liquid storage unit 13 from the third electrode 61c, that is, the chemical liquid storage unit 13 It is arranged at the other end in the axial direction.

The capacitance measuring unit 61 measures all capacitances of the four electrodes 61a, 61b, 61c, 61d and outputs them to the arithmetic unit 101 (see FIG. 3). Further, the capacitance measuring unit 61 includes the capacitance between the first electrode 61a and the second electrode 61b, the capacitance between the second electrode 61b and the third electrode 61c, and the third electrode 61c and the fourth electrode 61d. The capacitance between them is individually output to the calculation unit 101. Then, the calculation unit 101 calculates the amount of the drug solution stored in the drug solution storage unit 13 from the capacitances of the four electrodes 61a, 61b, 61c, 61d received from the capacitance measuring unit 61.

For example, when the gasket 18a moves beyond the third electrode 61c and the fourth electrode 61d to the vicinity of the second electrode 61b, the inside of the cylindrical hole of the chemical liquid storage unit 13 at the location where the third electrode 61c and the fourth electrode 61d face each other. The drug solution is discharged. The drug solution is still contained in the cylindrical hole of the drug solution storage unit 13 at the location where the first electrode 61a and the second electrode 61b face each other. Therefore, the capacitance between the third electrode 61c and the fourth electrode 61d is smaller than the capacitance between the first electrode 61a and the second electrode 61b.

In this way, the capacitance measuring unit 61 detects the variation in the capacitance between the electrodes, so that the amount of the chemical solution stored in the chemical solution storage unit 13 can be accurately detected.

Other configurations are the same as those of the chemical liquid administration device 1 according to the first embodiment, and therefore description thereof will be omitted. The liquid medicine administration device 51 having the capacity measuring unit 61 having such a configuration can also obtain the same effects as the liquid medicine administration device 1 according to the above-described first embodiment.

3. Third Embodiment Example Next, a drug solution administration device according to a third embodiment example will be described with reference to FIG. 10.
FIG. 10 is a plan view showing the capacitance measuring unit according to the third embodiment.

The liquid medicine administration device according to the third embodiment is obtained by changing the shape of the electrode of the capacitance measuring unit 61 according to the second embodiment. Therefore, the electrodes of the capacitance measuring unit will be described here, and the other description will be omitted.

As shown in FIG. 10, the capacitance measuring unit 71 has four electrodes 71a, 71b, 71c, 71d. Note that the locations where the four electrodes 71a, 71b, 71c, 71d are arranged are the same as the four electrodes 61a, 61b, 61c, 61d of the capacitance measuring section 61 according to the second embodiment, and therefore the description thereof is omitted. Is omitted.

The four electrodes 71a, 71b, 71c, 71d are formed in a flat plate shape. The sides of the four electrodes 71a, 71b, 71c, 71d that are adjacent to the other electrodes are formed in a convex shape or a concave shape. The side of the first electrode 71a adjacent to the second electrode 71b is formed in a concave shape. The side of the second electrode 71b adjacent to the first electrode 71a is formed in a convex shape corresponding to the concave shape of the first electrode 61a.

The side of the second electrode 71b adjacent to the third electrode 71c is formed in a concave shape. The side of the third electrode 71c adjacent to the second electrode 71b is formed in a convex shape corresponding to the concave shape of the second electrode 71b. The side of the third electrode 71c adjacent to the fourth electrode 71d is formed in a concave shape, and the side of the fourth electrode 71d adjacent to the third electrode 71c is formed in a convex shape corresponding to the concave shape of the third electrode 71c. Is formed in.

Other configurations are the same as those of the chemical liquid administration device 1 according to the first embodiment, and therefore description thereof will be omitted. Also with the liquid medicine administration device having the volume measuring unit 71 having such a configuration, the same operational effects as those of the liquid medicine administration device 1 according to the above-described first embodiment can be obtained.

4. Fourth Embodiment Next, a drug solution administration device according to a fourth embodiment will be described with reference to FIG.
FIG. 11 is a plan view showing the capacitance measuring unit according to the fourth embodiment.

The drug solution administration device according to the fourth embodiment is obtained by changing the shape of the electrode of the capacitance measuring unit 61 according to the second embodiment. Therefore, the electrodes of the capacitance measuring unit will be described here, and the other description will be omitted.

As shown in FIG. 11, the capacitance measuring section 81 has four electrodes 81a, 81b, 81c and 81d. Note that the locations where the four electrodes 81a, 81b, 81c, and 81d are arranged are the same as the four electrodes 61a, 61b, 61c, and 61d of the capacitance measuring section 61 according to the second embodiment, and therefore the description thereof is omitted. Is omitted.

The four electrodes 81a, 81b, 81c, 81d are formed in a flat plate shape. The sides of the four electrodes 81a, 81b, 81c, 81d that are adjacent to the other electrodes are formed in two convex shapes or two concave shapes. The positional relationship between the two convex portions and the two concave portions formed on the four electrodes 81a, 81b, 81c, 81d is four electrodes 71a, 71b, 71c, 71d according to the third embodiment. Since it is the same as, the description thereof will be omitted.

Other configurations are the same as those of the chemical liquid administration device 1 according to the first embodiment, and therefore description thereof will be omitted. Also with the drug solution administration device having the volume measuring unit 81 having such a configuration, the same effects as those of the drug solution administration device 1 according to the above-described first embodiment can be obtained.

In addition, according to the capacitance measuring unit 71 according to the third embodiment and the capacitance measuring unit 81 according to the fourth embodiment, the variation of the capacitances of all the four electrodes with respect to the variation of the amount of the chemical solution can be calculated. It can be made smoother than the capacitance measuring unit 61 according to the second embodiment. As a result, the volume measuring unit 71 according to the third embodiment and the volume measuring unit 81 according to the fourth embodiment have a larger amount of chemical liquid than the volume measuring unit 61 according to the second embodiment. The detection accuracy of can be improved.

Heretofore, the embodiments of the present invention have been described, including the effects thereof. However, the drug solution administration device of the present invention is not limited to the above embodiment, and various modifications can be made without departing from the scope of the invention described in the claims.

In the above-described embodiment, an example in which an insulin pump that administers insulin is applied as the drug solution administration device has been described, but the invention is not limited to this. As the drug solution to be administered, various other drug solutions such as an analgesic drug, an anticancer drug, an HIV drug, an iron chelating drug, and a drug for treating pulmonary hypertension may be used.

DESCRIPTION OF SYMBOLS 1, 51...Medicinal-solution administration device, 13...Medicinal-solution storage part, 13a...Transmission port (reference capacity part), 13b...Filling port, 13c...Cylinder hole, 14...Transmission mechanism, 15...Driving part, 17...Power supply part, 18... Pusher member, 18a... Gasket, 21... Rotation detecting part, 22... Pusher operating part, 31, 61, 71, 81... Capacity measuring part, 31a... 1st electrode, 31b... 2nd electrode, 32... Reference Capacitance measuring unit, 32a... First reference electrode, 32b... Second reference electrode, 101... Computing unit

Claims (7)

A drug solution storage part formed in a tubular shape and filled with a drug solution,
A pusher member for pushing out the chemical liquid filled in the chemical liquid storage section,
A pusher operating section for operating the movement of the pusher member,
A drive unit that applies a drive force to the pusher operation unit,
Having a plurality of electrodes arranged to face the outer wall of the drug solution storage unit, a capacitance measuring unit for measuring the capacitance between the plurality of electrodes,
A computing unit for computing the amount of the chemical liquid filled in the chemical liquid storage unit from the capacitance measured by the capacitance measuring unit,
A reference volume unit that stores a predetermined amount of the chemical liquid,
Having a reference electrode arranged to face the reference capacitance section, a reference capacitance measuring section for measuring a reference capacitance which is the capacitance of the reference electrode , and
The arithmetic unit is
Corrects the administration threshold based on the reference capacitance measured by the reference capacitance measuring unit during administration of the drug solution, and adjusts the corrected administration threshold and the capacitance measured by the capacitance measuring unit during administration of the drug solution. Based on the determination, the amount of the drug solution filled in the drug solution storage unit is determined.
Drug delivery device. The calculation unit corrects the pre-administration threshold value based on the reference capacitance measured by the reference volume measurement unit before administering the drug solution, and measures the volume before the administration of the corrected pre-administration threshold value and the drug solution. Determine the amount of the chemical liquid filled in the chemical liquid storage unit based on the capacitance measured by the unit.
The drug solution administration device according to claim 1. The chemical liquid storage unit has a liquid supply port for discharging the stored chemical liquid,
The reference capacitor unit, the chemical solution administration device according to claim 1 or 2 which is the liquid delivery port. The inner diameter of the cylindrical hole in which the chemical liquid is stored in the chemical liquid storage unit is set to have the same size from one end to the other end in the axial direction of the chemical liquid storage unit. Drug delivery device. The surfaces of the chemical solution storage unit facing the plurality of electrodes are formed in a flat plate shape, and the distance between the plurality of electrodes and the chemical solution storage unit is the same from one end to the other end in the axial direction of the chemical solution storage unit. The drug solution administration device according to claim 4 , wherein the drug solution administration device is set at intervals. The drug solution administration device according to claim 1, wherein the plurality of electrodes are arranged at a predetermined interval in the axial direction of the drug solution storage unit. The arithmetic unit controls the drive of the drive unit so as to deliver a predetermined amount of the chemical liquid, and the chemical liquid is delivered based on the capacitance of the plurality of electrodes before and after the operation of delivering the predetermined amount of the chemical liquid. The drug solution administration device according to any one of claims 1 to 6, which detects blockage of a flow path.

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