JP6717201B2 - 検出方法および検出装置 - Google Patents
検出方法および検出装置 Download PDFInfo
- Publication number
- JP6717201B2 JP6717201B2 JP2016564806A JP2016564806A JP6717201B2 JP 6717201 B2 JP6717201 B2 JP 6717201B2 JP 2016564806 A JP2016564806 A JP 2016564806A JP 2016564806 A JP2016564806 A JP 2016564806A JP 6717201 B2 JP6717201 B2 JP 6717201B2
- Authority
- JP
- Japan
- Prior art keywords
- metal film
- light
- substance
- detected
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001514 detection method Methods 0.000 title claims description 125
- 229910052751 metal Inorganic materials 0.000 claims description 263
- 239000002184 metal Substances 0.000 claims description 263
- 239000000126 substance Substances 0.000 claims description 129
- 230000005284 excitation Effects 0.000 claims description 111
- 238000003860 storage Methods 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 25
- 238000012545 processing Methods 0.000 claims description 20
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 13
- 230000001678 irradiating effect Effects 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 238000009529 body temperature measurement Methods 0.000 claims description 8
- 238000002372 labelling Methods 0.000 claims description 6
- 239000012491 analyte Substances 0.000 claims description 3
- 239000013076 target substance Substances 0.000 claims description 2
- 239000010408 film Substances 0.000 description 224
- 230000007246 mechanism Effects 0.000 description 46
- 230000003287 optical effect Effects 0.000 description 42
- 238000012937 correction Methods 0.000 description 18
- 239000010409 thin film Substances 0.000 description 13
- 238000010586 diagram Methods 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 238000010517 secondary reaction Methods 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 7
- 239000007850 fluorescent dye Substances 0.000 description 6
- 238000001215 fluorescent labelling Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 238000012921 fluorescence analysis Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000013545 self-assembled monolayer Substances 0.000 description 3
- 239000004909 Moisturizer Substances 0.000 description 2
- -1 aliphatic thiols Chemical class 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000002073 fluorescence micrograph Methods 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000003574 free electron Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000002094 self assembled monolayer Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000001931 thermography Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014253407 | 2014-12-15 | ||
JP2014253407 | 2014-12-15 | ||
PCT/JP2015/084492 WO2016098653A1 (fr) | 2014-12-15 | 2015-12-09 | Procédé de détection et dispositif de détection |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2016098653A1 JPWO2016098653A1 (ja) | 2017-09-21 |
JP6717201B2 true JP6717201B2 (ja) | 2020-07-01 |
Family
ID=56126545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016564806A Expired - Fee Related JP6717201B2 (ja) | 2014-12-15 | 2015-12-09 | 検出方法および検出装置 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP6717201B2 (fr) |
WO (1) | WO2016098653A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019082637A1 (fr) * | 2017-10-25 | 2019-05-02 | 株式会社堀場製作所 | Appareil d'analyse de résonance de plasmon de surface, et procédé d'analyse de résonance de plasmon de surface |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0517930B1 (fr) * | 1991-06-08 | 1995-05-24 | Hewlett-Packard GmbH | Procédé et appareil pour détecter la présence et/ou la concentration de biomolécules |
JPH09257699A (ja) * | 1996-03-19 | 1997-10-03 | Toto Ltd | 表面プラズモン共鳴センサ装置 |
JP2003065947A (ja) * | 2001-08-29 | 2003-03-05 | Matsushita Electric Ind Co Ltd | 屈折率測定装置、屈折率測定方法、および定性定量分析装置 |
JP3910498B2 (ja) * | 2002-07-08 | 2007-04-25 | 富士フイルム株式会社 | 測定装置 |
US20050186565A1 (en) * | 2003-02-10 | 2005-08-25 | American Environmental Systems, Inc. | Method and spectral/imaging device for optochemical sensing with plasmon-modified polarization |
US20060194346A1 (en) * | 2004-02-18 | 2006-08-31 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Surface plasmon-field-enhanced diffraction sensor |
JP2010038624A (ja) * | 2008-08-01 | 2010-02-18 | Fujifilm Corp | 検出方法及び検出装置 |
JP5640873B2 (ja) * | 2011-04-07 | 2014-12-17 | コニカミノルタ株式会社 | 表面プラズモン励起蛍光計測装置及び表面プラズモン励起蛍光計測方法 |
JP2012225778A (ja) * | 2011-04-20 | 2012-11-15 | Konica Minolta Holdings Inc | 検査チップ及び計測装置 |
JP5363631B2 (ja) * | 2011-09-28 | 2013-12-11 | 富士フイルム株式会社 | 蛍光粒子を用いた検出対象物質の検出方法 |
-
2015
- 2015-12-09 WO PCT/JP2015/084492 patent/WO2016098653A1/fr active Application Filing
- 2015-12-09 JP JP2016564806A patent/JP6717201B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPWO2016098653A1 (ja) | 2017-09-21 |
WO2016098653A1 (fr) | 2016-06-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6337905B2 (ja) | 表面プラズモン共鳴蛍光分析方法および表面プラズモン共鳴蛍光分析装置 | |
US20200256796A1 (en) | Method of manufacturing sensing chip and sensing chip | |
JP6991972B2 (ja) | 検出チップ、検出システムおよび検出方法 | |
JPWO2015182747A1 (ja) | 表面プラズモン増強蛍光測定方法、表面プラズモン増強蛍光測定装置および分析チップ | |
JP5344828B2 (ja) | センシング装置 | |
JP6760384B2 (ja) | 測定方法 | |
JPWO2018034208A1 (ja) | 測定方法 | |
JP6717201B2 (ja) | 検出方法および検出装置 | |
JP2015111063A (ja) | 表面プラズモン増強蛍光測定方法および表面プラズモン増強蛍光測定装置 | |
US10976250B2 (en) | Position detection method and position detection device for sensor chip in optical sample detection system | |
US11169090B2 (en) | Diffracted light removal slit and optical sample detection system using same | |
JP6711285B2 (ja) | 検出方法、検出装置およびチップ | |
JP6954116B2 (ja) | 測定方法、測定装置および測定チップ | |
JPWO2019221040A1 (ja) | 検体検出チップ及びこれを用いた検体検出装置 | |
JP6586884B2 (ja) | チップおよび表面プラズモン増強蛍光測定方法 | |
JP6399089B2 (ja) | 表面プラズモン共鳴蛍光分析方法、表面プラズモン共鳴蛍光分析装置および位置合わせ方法 | |
WO2021009995A1 (fr) | Dispositif de détection et procédé de détection | |
JP2008267959A (ja) | 検査装置 | |
WO2016147774A1 (fr) | Procédé de mesure et dispositif de mesure | |
JP6221785B2 (ja) | 検出装置および検出方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180614 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190528 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20190708 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20191011 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191112 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200110 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200512 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200525 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6717201 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
LAPS | Cancellation because of no payment of annual fees |