JP6716682B2 - 脳刺激システム - Google Patents
脳刺激システム Download PDFInfo
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- JP6716682B2 JP6716682B2 JP2018507559A JP2018507559A JP6716682B2 JP 6716682 B2 JP6716682 B2 JP 6716682B2 JP 2018507559 A JP2018507559 A JP 2018507559A JP 2018507559 A JP2018507559 A JP 2018507559A JP 6716682 B2 JP6716682 B2 JP 6716682B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/377—Electroencephalography [EEG] using evoked responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Electrotherapy Devices (AREA)
- Magnetic Treatment Devices (AREA)
Description
図1を参照すると、本発明の脳刺激を通じた記憶向上方法は、脳反応活性化程度を測定する段階と、脳皮質ターゲット領域を選定する段階と、一般の脳反応信号を受信して測定する段階と、刺激後、脳反応信号を測定する段階と、脳活動変化の有無を判断する段階と、含んでもよい。
図3を参照すると、本発明の脳刺激を通じた記憶向上方法は、前記使用者の脳皮質領域中の少なくとも一つの脳皮質ターゲット領域を選定することができる。さらに具体的に、ターゲット候補群領域のうち、最も克明に脳反応信号の変化が測定される領域を決定し、このような領域を脳皮質ターゲット領域として選定することができる。
S120 脳皮質ターゲット領域を選定する段階
S130 一般の脳反応信号を受信して測定する段階
S140 刺激後、脳反応信号を測定する段階
S150 脳活動変化の有無を判断する段階
Claims (9)
- 使用者の脳に対する電気刺激のための電気信号を生成する電子装置と、
使用者の脳反応信号を処理する処理装置と、
を備え、
(a)前記電子装置が使用者の脳に対する電気刺激のための電気信号を生成し、使用者の脳皮質領域における脳反応活性化程度を測定する処理と、
(b)前記処理装置が、前記脳反応活性化程度に基づいて前記使用者の脳皮質領域のうち、少なくとも一つの脳皮質ターゲット領域を選定する処理と、
(c)前記処理装置が、前記脳皮質ターゲット領域において、刺激物による使用者の一般の脳反応信号を受信して測定する処理と、
(d)前記電子装置が前記脳皮質ターゲット領域に対する脳活性化誘導電気刺激を生成し、前記刺激物と共に前記誘導電気刺激による刺激後、脳反応信号を測定する処理と、
(e)前記処理装置が、前記(c)処理の脳反応信号に対する前記(d)処理の脳反応信号の変化を測定し、脳活動変化の有無を判断する処理と、
(f)前記処理装置が、前記(d)処理の脳反応信号の形態的または時期的な特徴点(feature)の値を計算し、前記特徴点の値が既に設定済みの臨界値を超える脳反応信号を誘導する刺激信号のパラメータを選定する脳刺激システム。 - 前記電子装置は、
経頭蓋磁気刺激器(TMS;Transcranial Magnetic Stimulation)、経頭蓋直流電気刺激器(tDCs;Transcranial Direct Current Stimulation)、超音波脳刺激器の中の少なくともいずれか一つを含むことを特徴とする請求項1に記載の脳刺激システム。 - 前記(a)処理は、
前記電子装置が前記使用者の脳の海馬に対する電気刺激のための電気信号を生成し、脳皮質領域において示されるシータパワー量(theta frequency amplitude)の増加またはガンマパワー量(gamma frequency amplitude)の増加を通じて脳反応活性化程度を測定し、
前記(b)処理は、
前記使用者の海馬に対する電気刺激と、前記シータパワー量の増加量または前記ガンマパワー量の増加量との相関関係が最も高い領域を脳皮質ターゲット領域として選定することを特徴とする請求項1に記載の脳刺激システム。 - 前記(b)処理は、
前記使用者の脳皮質領域は、
前頭葉、頭頂葉、内側側頭葉、海馬、下部側頭葉、中部側頭葉、上部側頭葉の中の少なくともいずれか一つを含むことを特徴とする請求項1に記載の脳刺激システム。 - 前記(b)処理は、
使用者の脳皮質領域のうち、脳反応活性化が最も増加した領域を脳皮質ターゲット領域として選定することを特徴とする請求項1に記載の脳刺激システム。 - 前記(d)処理は、
侵襲的または非侵襲的な方法により、物理的に脳皮質ターゲット領域に脳活性化誘導電気刺激を加えるための電気信号を生成することを特徴とする請求項1に記載の脳刺激システム。 - 前記特徴点は、
特定の周波数、周波数領域内の振幅値、反応時間、低周波及び高周波程度の中の少なくともいずれか一つの情報を含むことを特徴とする請求項1に記載の脳刺激システム。 - 前記(f)処理は、
脳反応信号からノイズ信号を除去し、エポック(epoching)処理することを特徴とする請求項1に記載の脳刺激システム。 - 前記形態的または時期的な特徴点は、認知課題に対する複数の試行における脳波から繰り返し測定されたものである請求項1に記載の脳刺激システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2017-0006991 | 2017-01-16 | ||
KR1020170006991 | 2017-01-16 | ||
PCT/KR2017/014288 WO2018131795A2 (ko) | 2017-01-16 | 2017-12-07 | 뇌 자극을 통한 기억 향상 방법 |
Publications (2)
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JP2019508073A JP2019508073A (ja) | 2019-03-28 |
JP6716682B2 true JP6716682B2 (ja) | 2020-07-01 |
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JP (1) | JP6716682B2 (ja) |
WO (1) | WO2018131795A2 (ja) |
Family Cites Families (4)
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EP2207591A2 (en) * | 2007-10-04 | 2010-07-21 | Neuronix Ltd. | Systems and methods for treatment of medical conditions related to the central nervous system and for enhancing cognitive functions |
US9403010B2 (en) * | 2010-12-17 | 2016-08-02 | The Regents Of The University Of California | Specific deep brain stimulation for enhancement of memory |
US20150105837A1 (en) * | 2013-10-16 | 2015-04-16 | Neurometrics, S.L. | Brain therapy system and method using noninvasive brain stimulation |
EP3247267B1 (en) * | 2015-01-24 | 2021-07-07 | The Trustees of the University of Pennsylvania | Apparatus for improving cognitive performance |
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WO2018131795A2 (ko) | 2018-07-19 |
JP2019508073A (ja) | 2019-03-28 |
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