JP6695171B2 - Eye drop container monitoring system - Google Patents

Description

  TECHNICAL FIELD The present invention relates to an eye drop container monitoring system for monitoring an eye drop container for prescribing an eye drop for reducing the intraocular pressure of a glaucoma patient, for example.

  BACKGROUND ART Conventionally, eye drops and the like for lowering intraocular pressure have been prescribed for glaucoma patients. Eye drops are very important in the treatment of ophthalmic diseases, and many eye drops are prescribed for proper use.

  However, it has been pointed out that in recent years, a very large economic loss has been caused by the disposal of "remaining medicines" that occurred when, for example, the eye drop was stopped by self-determination. In order to avoid the occurrence of residual medicine, pharmacists and the like provide eye drop instruction, but it is not an effective means for all patients. In the first place, the amount of eye drops used depends on the individual such as age, sex, disease severity, and understanding level, and that depending on the difference in the liquid chemicals such as consistency, specific gravity, and eye drop bottle structure. At the same time, various parameters such as the number of eye drops are involved. Therefore, it is the current situation that the confirmation of the usage status is not known not only about whether it is being used properly but also whether eye drops are being applied. It is estimated that about two-thirds of the actually prescribed eye drops are discarded as residual medicines, and the economic loss is estimated to be several hundred billion yen to several trillion yen.

  Under such circumstances, at present, the effects of eye drops prescribed for glaucoma patients are not clearly shown. This may be because the prescribed eye drops had no effect on the disease of glaucoma patients, or whether the glaucoma patients did not use the eye drops properly or did not drop them. This is because the cause cannot be specified. Therefore, when the cause of the deterioration of glaucoma cannot be identified and the effect of the drug is not recognized, it is unavoidable that it is necessary to take an operation.

  In Patent Document 1, a motion detection sensor or a pressure sensor is attached to an eye drop (ophthalmic dispenser), a motion of an eye drop container is detected, an eye drop amount is recorded, and data is transmitted to a computer of a family member or a doctor or a portable communication device. There is disclosed a portable management and monitoring system for eye drops, which is provided with a module (claim 1 of Patent Document 1, gazette column 2, line 33 to column 51, line 4, column 15 to column 15). 55th line, 5th column, 16th line to 61st line of the same column, 6th column, 7th line to 24th line of the same column, FIGS. 2 and 5 to 7).

  In addition, Patent Document 2 describes a technique for tracking the position and timing of ophthalmic drug distribution by including an additional sensor such as an accelerometer and / or GPS in an eye drop (ophthalmic dispenser) (Patent Document 2). Line numbers 0017, 0057, 0074).

US899861 publication Special table 2014-528793 gazette

  However, in Patent Document 1, a motion detection sensor, a pressure sensor, a drop amount detection sensor, etc. for detecting the motion of the eye drop is provided, and the motion of the eye drop, the eye drop amount, etc. are detected to detect whether or not the eye drop is used. However, the present invention relates to a monitoring system that encourages the use of eye drops, for example, whether the eye drops should be changed by analyzing the relationship between the intraocular pressure of the glaucoma patient, the disease progression status of the visual field or the fundus disease part and the eye drop status of the eye drops. Or, it is not possible to provide the data for deciding whether or not the fundus diseased part should be operated. Further, as described in Patent Document 2, it is not possible to analyze the eyedrop situation of a glaucoma patient only by tracking the position and timing of ophthalmic drug distribution.

  Therefore, in the present invention, while detecting the operation of the eye drop container by the eye drop movement detection means, the patient's intraocular pressure, the condition of the visual field or the disease state of the fundus disease part is examined, for example, the glaucoma patient's intraocular pressure, the visual field or the fundus. The purpose is to provide a data for analyzing the relationship between the disease progression status of the diseased part and the ophthalmic solution of the eye drop and determining whether the eye drop should be changed or the fundus diseased part should be operated.

  Another object is to educate patients about the importance of eye drop treatment and reduce the choice of surgery due to the lack of efficacy of the drug.

  Another object of the present invention is to improve the accuracy of prediction in disease analysis for analyzing diseases that are likely to develop, because it is possible to link medication information with patient charts. Another purpose is to reduce the problem that medicines are left and discarded and contribute to the reduction of insurance medical costs.

The invention according to claim 1, the ophthalmic operation information ophthalmic operation detecting means detects that detects the operation of the eyedrops container, on the basis of the eye patient information input, the status of the patient eye conditions and diseases The eye information is a thickness of the rim portion of the optic disc portion of the fundus measured by OCT, and the analyzing means has a time elapsed from the start of instillation and the optic disc portion. Of the thickness of the rim portion in the future, based on the relationship between the elapsed time from the start of the instillation and the thickness of the rim portion of the optic disc, The first estimated value, and the analyzing means uses the eyedrop container to apply an eyedrop based on the relationship between the elapsed time from the start of the eyedrop and the thickness of the rim portion of the optic nerve head. The eye drop container monitoring system predicts the thickness of the rim portion in the future when another eye drop different from the existing eye drop is used as a second predicted value .

The invention according to claim 2 is an eyedrop container monitoring system for monitoring eyedrops using an eyedrop container , wherein the eyedrop operation means transmits the eyedrop operation information, and the eyedrop recording the eyedrop operation information transmitted from the transmission means. Action recording means, obtaining means for obtaining the eyedrop movement information recorded in the eyedrop movement recording means, eyedrop movement information obtained by the obtaining means, input patient eye information, and patient's day or It has an analysis means for analyzing the eyedrop operating state of the patient based on the data of the number of times of eyedrops for each month, and the eye information is the thickness of the rim portion of the optic nerve head of the fundus measured by OCT, The analysis means obtains the relationship between the elapsed time from the start of instillation and the thickness of the rim portion of the optic papilla, and the analysis means, the elapsed time from the start of the instillation and the optic papilla. Based on the relationship of the thickness of the rim portion, the thickness of the rim portion in the future is predicted as a first predicted value, and the analyzing unit calculates the elapsed time from the start of the instillation and the optic disc head. Based on the relationship of the thickness of the rim portion of, the thickness of the rim portion in the future when another eye drop different from the eye drop that has been applied using the eye drop container is used as the second expected value. This is an expected eye drop container monitoring system.

The invention according to claim 3 is based on the eyedrop movement detection step of detecting the movement of the eyedrop container, the eyedrop movement information detected in the eyedrop movement detection step, and the patient's input eye information. An eyedrop situation and an analysis step of analyzing a disease situation, wherein the eye information is the thickness of the rim portion of the optic disc of the fundus measured by OCT, and in the analysis step, the eyedrop is started. The relationship between the elapsed time and the thickness of the rim portion of the optic papilla is determined, and in the analyzing step, based on the relationship between the elapsed time from the start of the instillation and the thickness of the rim portion of the optic papilla. , Predicting the thickness of the rim portion in the future as a first predicted value, and the analyzing step is based on the relationship between the elapsed time from the start of the instillation and the thickness of the rim portion of the optic papilla. A method for monitoring an eyedrop container that predicts the thickness of the rim portion in the future as a second predicted value when another eyedrop that is different from the eyedrop that has been applied using the eyedrop container is used .

The invention according to claim 4 is a program to be read and executed by a computer, wherein eye drop operation information detected by eye drop operation detection means for detecting the operation of the eye drop container by the computer, and input eye information of the patient. Based on, it is operated as an analyzing means for analyzing the instillation situation and disease situation of the patient, the eye information is the thickness of the rim portion of the optic disc of the fundus measured by OCT, and the analyzing means is Obtaining the relationship between the elapsed time from the start of instillation and the thickness of the rim portion of the optic papilla, the analysis means, the elapsed time from the start of the instillation and the thickness of the rim portion of the optic papilla The thickness of the rim portion in the future is predicted as a first predicted value based on the above relationship of the thickness, and the analyzing unit calculates the elapsed time from the start of the instillation and the thickness of the rim portion of the optic papilla. Based on the above relationship, the eyedrop container monitoring for predicting the thickness of the rim portion in the future as a second predicted value when another eyedrop that is different from the eyedrop that has been applied using the eyedrop container is used. It is a program for.

  According to the present invention, the movement of the eye drop container is detected, and the disease status of the fundus disease part of the patient is inspected. For example, the intraocular pressure of the glaucoma patient, the disease progression status of the disease part of the visual field or the fundus and the eye drop status of the eye drop. Can be analyzed to determine whether to change eye drops or to operate on the diseased part of the fundus. Further, according to the present invention, eye drop treatment can be promoted by constantly monitoring the eye drop condition of the patient.

  Further, according to the present invention, it is possible to educate a patient about the importance of eye drop treatment, and it is possible to reduce the situation in which surgery is selected because the effect of the drug is not recognized.

  Further, according to the present invention, it is possible to reduce the problem that a drug remains and is discarded, it is possible to achieve cooperation between the medication information and the patient chart, and the prediction accuracy in a disease analysis for analyzing a disease that is likely to develop Can be improved. Further, according to the present invention, it is possible to contribute to a reduction in insurance medical expenses due to a reduction in remaining medicines.

It is a conceptual diagram of embodiment. It is a block diagram of an embodiment. It is a graph explaining embodiment.

  An eye drop container equipped with an acceleration sensor and a transmitter for transmitting a signal from the acceleration sensor is prepared. FIG. 1 shows an outline of the above eye drop container. FIG. 1 shows an eye drop container 100. The eye drop container 100 includes a container body 101 and an acceleration sensor 102 fixed to the container body 101. A transmitter 103 is connected to the acceleration sensor 102 by flexible wiring. Note that the transmitter 103 has a built-in battery as a power source, and the power of this battery is also supplied to the acceleration sensor 102 via wiring. The acceleration sensor 102 detects acceleration in the xyz directions that are orthogonal to each other. The acceleration sensor 102 includes an A / D converter, and the detected acceleration data is output from the acceleration sensor 102 as a digital signal. The output of the acceleration sensor 102 is sent to the transmitter 103, and is wirelessly transmitted from the transmitter 103 to the outside. The transmitter 102 performs wireless transmission of the Blue tooth (registered trademark) standard. As the transmitter 102, infrared optical communication, a mobile phone communication line, or the like can be used.

  A small recording device 200 for recording the signal from the transmitter 102 is installed in the home of the patient. The small recording device 200 stores the detection data of the acceleration sensor 102 in association with the detection time. The patient brings the compact recording device 200 when coming to the hospital for consultation. Instead of the small recording device 200, a PC (personal computer), a tablet, or a smartphone can be used. In this case, the signal from the eye drop container 100 is received and recorded by the PC, tablet or smartphone. Further, in this case, the content received from the eye drop container 100 can be transmitted to the hospital via the Internet line or the telephone line.

  At the hospital, the data regarding the operation status of the eye drop container 100 is acquired from the small recording device 200 brought by the patient. Further, for example, when a smartphone is used instead of the small-sized recording device 200, the hospital side acquires the data regarding the operation status of the eyedrop container 100 stored in the smartphone. The data regarding the operation status of the eyedropper container is data of the number of times of eyedrops of the patient on a daily or monthly basis.

(For glaucoma)
At the examination, a tonometer is used to measure the intraocular pressure of the patient. Alternatively, the visual field of the patient is measured using a perimeter. Alternatively, an OCT (optical coherence tomography), which is a fundus tomography apparatus, is used to capture a tomographic image of the papilla, macula, etc. at the fundus of the patient.

  In an example of the examination of the fundus of the patient using OCT, the thickness of the cup portion and the rim portion of the fundus papilla are measured, and the data is recorded. Conduct this examination regularly. Note that the examination intervals do not necessarily have to be equal intervals. Prescribe eye drops according to the glaucoma status obtained from the diagnosis. For example, if the patient has advanced glaucoma despite normal intraocular pressure, an eye drop such as Tabros® eye drop 0.0015% is prescribed. In this case, the patient instills at an interval designated by the doctor (for example, once a day or once every two days).

  FIG. 2 shows the diagnostic device 300. In this example, a program that executes the functions of FIG. 2 is installed in a personal computer used by a doctor, and the diagnostic device 300 is configured by software. Part or all of the illustrated functional units may be configured by a dedicated arithmetic circuit. For example, each functional unit illustrated is configured by an electronic circuit such as a CPU (Central Processing Unit), an ASIC (Application Specific Integrated Circuit), and a PLD (Programmable Logic Device) such as an FPGA (Field Programmable Gate Array). Whether each functional unit is configured by dedicated hardware or software by executing a program in the CPU is determined in consideration of the required calculation speed, cost, power consumption, and the like. For example, if the specific function unit is configured by an FPGA, it is advantageous in terms of processing speed but high in cost. On the other hand, the configuration in which a specific functional unit is realized by executing a program by the CPU can save hardware resources, and thus has a cost advantage. However, when the functional unit is realized by the CPU, the processing speed is inferior to that of dedicated hardware. Further, when the functional unit is realized by the CPU, it may not be possible to deal with complicated calculation. It should be noted that configuring the functional unit with dedicated hardware and configuring it with software are equivalent from the viewpoint of realizing a specific function, although there are differences as described above.

  The diagnostic device 300 includes an eye drop data acquisition unit 301, an eye drop effect determination unit 302, an affected part measurement data acquisition unit 303, a storage unit 306, and a display unit 307. The eye drop data acquisition unit 301 extracts data relating to an eye drop operation using the eye drop container 100 from the data of the acceleration sensor 102 recorded in the small recording device 200. When a patient performs instillation, first, the eyedrop container is lifted, then the eyedrop container is turned upside down or close thereto, and the drug solution is dropped on the eye. The detection pattern of the acceleration detected by the acceleration sensor 102 in this operation has been examined in advance, and the data thereof is stored in the storage unit 306. The eye drop data acquisition unit 301 compares the acceleration detection pattern related to the eye drop operation stored in the storage unit 306 with the raw data stored in the small-sized storage device 200, and converts the raw data into the eye drop operation using the eye drop container 100. Extract the relevant data. The extracted data is stored in the storage unit 306 in association with the time when the eyedropping operation is performed.

  The eye-drop effect determination unit 302 determines the effect of eye-drop according to the determination criteria described later. The result of this determination is displayed on the display unit 307, which is the display of the PC operating as the diagnostic device 300. The affected part measurement data acquisition unit 303 acquires fundus information (in this example, information on the thickness (mm) of the rim portion of the papilla (optic nerve head)) measured by OCT (optical coherence tomography).

  The storage unit 306 stores data handled by the diagnostic device 300 and a program for operating the diagnostic device 300. A storage area provided in a semiconductor memory or a hard disk device is used as the storage unit 306. The display unit 307 is a display (for example, a liquid crystal display) of a PC operated as the diagnostic device 300. In addition, it is possible to input data to the diagnostic device 300 and output data from the diagnostic device 300 to an external device using the interface of the PC.

  The criteria for the determination performed by the eye-drop effect determination unit 302 will be described below. Table 1 shows an example of the determination table used for the determination.

  FIG. 3 shows an example of a case where the vertical axis represents the thickness (mm) of the rim portion of the nipple and the horizontal axis represents the date and time, and the progress data from one to two years ago to the present is plotted. In the case of glaucoma, the vertical axis takes the data of the fundus region (thickness of the fundus layer (mm)) indicating the condition of the disease such as the thickness (mm) of the rim portion of the papilla, and the horizontal axis shows 1-2 years ago. The diagnosis is performed by taking the elapsed time (t) from to the present and plotting the change in the thickness of the rim portion. The values on the vertical axis and the horizontal axis in FIG. 3 are relative values.

  In FIG. 3, the thickness of the rim portion of the teat measured by OCT from the time when the administration of the eye drop (A) was started is plotted, and the change in the thickness of the rim portion is shown by a straight line descending to the right. It is shown that the eye drops (A) are continuously administered even after the present time point, and the rim portion disappears after X days (or X years), leading to blindness. Here, at a certain point of time, the eye drop is changed to the eye drop (B) and administration is started, and the thickness of the rim portion of the teat measured by OCT is plotted. At this time, the difference Δt between the thickness of the rim portion of the nipple when changing to the eye drop (B) and the expected value of the thickness of the rim portion of the nipple when continuing to administer the eye drop (A) is obtained. .. Here, the predicted value is obtained by extrapolation based on the data obtained so far. Note that FIG. 3 shows a case where the relationship between the horizontal axis and the vertical axis is a downward-sloping straight line, but the fitting function obtained from the measured values is not limited to the straight line.

  When Δt is, for example, 0.5 mm or more, it is determined that the intraocular pressure is suppressed and the effect is exerted as a result of administration of the eye drop (B). At this time, 0.5 mm is the minimum thickness of the rim portion that maintains the visual acuity.

  However, when Δt is, for example, 0.1 mm to 0.5 mm, it is analyzed that the eye drop (B) has no effect when it is detected that the eye drop container operation data is applied at least once a day.

  Similarly, when the difference is, for example, 0.1 mm to 0.5 mm, it is analyzed that the eye drop (B) has not been instilled when it is detected that the eye drop container operation data is applied only once a week. In this case, the patient is advised to instill the result on the mobile phone of the patient and instruct to instill it every day. For example, when the smartphone of the patient is used as the small storage device 200 in FIG. 1, it is possible to perform a notification display prompting eye drops on the display unit of the smartphone.

  In this way, the difference from the progress prediction graph that shows when blindness is reached when the eye drops are not administered is calculated, and the follow-up is performed for one month, or for several months, one year, and several years. Check whether the effect of the drug is exhibited. This determination is performed by the affected part measurement data determination unit 304 of the diagnostic device 300. The result is displayed on the display unit 307. The doctor refers to this determination result and determines whether to administer the eye drop as it is, change the eye drop, or perform surgery, and proceed with the treatment.

  Further, even when the eyedrop container operation data is not detected and no eyedrop is applied at all, a caution advertisement is displayed on the patient's mobile phone or the like so that the eyedropper is instructed to instill each day. As described above, the eyedrop situation can be grasped by combining the eyedrop container operation data and the data of the fundus observation device such as OCT.

In summary, based on the difference from the expected effect of eye drops obtained for the event (prescription change date),
(1) The eye drop is not effective or (2) The eye drop is not used.
Understand the patient's behavior by monitoring eye drops, and make an appropriate decision whether to continue administration of the same eye drops, change eye drops, or perform treatment such as surgery while watching the patient's disease progress status. To do.

  In Table 1, the frequency of instillation is determined on a daily basis, but the frequency of instillation may be determined on a daily basis, 3 day basis, weekly basis, or monthly basis depending on the symptom or drug.

According to this embodiment,
1. Acquire parameters such as the number of times of use and the amount used (per eye drop, total amount used) by using the acceleration sensor.
2. Introduce relationships between parameters such as exact usage and fluctuations in usage.
The standard usage can be estimated from Section 3.2.
4. By understanding the standard amount of use, it becomes possible to perform "eye drop instruction for pharmacists" based on it.
(Whether the amount of eye drops is larger or smaller than the standard is a basic guide when teaching)
5. (If used excessively) Measures can be taken to reduce the standard usage amount.
6. As a side effect, it becomes possible to estimate the total amount of eye drops used in the clinic that administers the sensor, and to control the inventory amount.
(Since the risk of managing pharmacies is reduced, it is possible to consider a method of re-migrating to an in-hospital pharmacy)

  Here, although glaucoma has been described as an example, the present invention is not limited to glaucoma, the anterior ocular segment, a diseased part such as intraocular pressure, or after cataract surgery or after retinal surgery, administration of eye drops and slits. The efficacy of eye drops is checked from the relationship with the disease status of the diseased part such as cornea, lens, intraocular eye, or retina by lamp, tonometer, perimeter, OCT, etc., and patient behavior is monitored by eye drop monitoring. It is possible to make an appropriate judgment while grasping the disease progression state of the patient and continuing administration of the same eyedrop, changing the eyedrop, or performing treatment such as surgery.

  For example, with a tonometer, determine the adequacy of the eye drop for the patient before and after administering the eye drop by the patient's intraocular pressure value and the sensor value of the eye drop container, for example, if the patient has proper intraocular pressure glaucoma, the intraocular pressure value is It is inspected whether it falls from an appropriate range (13 mm hectopascal or less for an adult) to 9 to 10 mm hectopascal, and when it does not fall to the low intraocular pressure value of 9 to 10 mm hectopascal, an eye drop (for example, tabros ( Appropriate diagnosis can be made whether to change the registered trademark) eye drops 0.0015%), to administer in combination with another eye drop, or to perform treatment such as surgery. In this case, a graph similar to that of FIG. 3 is created by using the diagnostic device of FIG. 2 and setting the vertical axis to the intraocular pressure value. Then, the same processing as that described with reference to FIG. 3 is performed to obtain the determination result regarding the effect of the instillation.

  Similarly, a perimeter is used to determine the adequacy of the eye drop for the patient before and after administration of the eye drop based on the visual field value (visual field test result) of the patient and the sensor value of the eye drop container. For example, when the patient has proper tension glaucoma , It is checked whether the visual field value falls from a proper range (angle of view of 120 degrees or more in the case of an adult) to 100 degrees of view. If the visual field value does not fall to the low field of view of 100 degrees, eye drops ( For example, it is possible to appropriately diagnose whether to change Tabros (registered trademark) eye drop (0.0015%), to administer it in combination with another eye drop, or to perform treatment such as surgery. In this case, using the diagnostic device of FIG. 2, a graph similar to that of FIG. 3 is created with the vertical axis as the visual field value. Then, the same processing as that described with reference to FIG. 3 is performed to obtain the determination result regarding the effect of the instillation.

  Thus, the relationship between the rim thickness of the fundus papilla and the sensor value of the eye drop container, the relationship between the intraocular pressure value and the sensor value of the eye drop container, the visual field value (visual field inspection result) and the sensor value of the eye drop container Due to the relationship, the prescribed eye drops, the usage status, and each measured value of the patient's eye can be linked together to obtain very useful data for the doctor to manage the patient's medical condition. it can.

  Similarly, in the treatment of corneal infections / dry eye, uveitis, etc., the administration of eye drops and the relationship between the OCT-related disease states of the lens, intraocular region, or retina etc. Whether to continue the administration of the same eye drop, change the eye drop, or perform treatment such as surgery while checking the efficacy and grasping the patient's behavior by eye drop monitoring and observing the patient's disease progress status Please be able to make an appropriate decision.

  The present invention can also be used for postoperative eye drops (eye drops after cataract surgery / retinal surgery (retinal detachment, etc.)). With regard to cataracts, the standard for the amount used is academically established. The eye drop sensor makes it possible to obtain an important index for suppressing excessive administration. Management after retinal surgery is similar. It should be noted that, at present, it is a fairly rough management, and overdose is usual.

The present invention can also be used for the following applications.
1. Treatment of Corneal Infection and Dry Eye According to the present invention, the clinical quality can be greatly improved by linking the therapeutic effect with the amount of eye drops. Specifically:
(A) It becomes possible to aim for healing in a shorter period.
(B) It becomes possible to clarify the reason why the therapeutic effect is not improved.
It is very important to clarify that it is the amount of eye drops, not the problem of the eye drops itself, such as the type of antibiotics and the type of dry eye drops.
2. Uveitis Treatment It is expected that there will be similar needs to the corneal area.
3. Eye drop management during hospitalization or during surgery during surgery A sensor can be used to manage eye drops during or during surgery during hospitalization. Actually, the instillation performed on a patient in a hospital is quite complicated and difficult to record, but the sensor can save the trouble of recording.

  Although the signal of the acceleration sensor is used as the operation signal of the eye drop container in the present invention, the invention is not limited to this. Other than that, an inclination sensor or an inertial measurement device (that is, Internal Measurement Unit, abbreviated as IMU) may be attached. An inertial measurement device is a device that detects the three-axis angle (or angular velocity) and acceleration that govern the motion of the eyedrop container, and is basically a three-dimensional gyroscope and a three-direction accelerometer. The angular velocity and acceleration can be calculated.

  In addition, a pressure sensor is placed in the eye drop container to detect how much eye drops have been used, calculate the usage fee, determine the correlation between the dose of the drug to be administered and the change status of the disease, and then prescribe. It can also be used to determine what treatment should be done.

  Not only the eye drop container, but also a mobile communication terminal such as a smartphone, a spectacle frame, cosmetics such as mascara and eye shadow, a wrist watch, a hat, and the like, the eye drop container for storing the eye drop is built into the eye drop container. You can be informed and regularly promote eye drops.

  In addition to ophthalmology, it may be applied to diseased parts such as internal medicine and surgery. The external medicine bag distributed by the pharmacy, the internal medicine bag, or the drug container, or the like, the same acceleration sensor, tilt sensor, inertial measurement device, a sensor such as a pressure sensor is arranged to detect the medication status such as the frequency of medication, It is also possible to calculate the dosage, obtain the correlation between the dose of the drug to be administered and the change status of the disease, and use it as a material for determining what treatment should be prescribed next.

  100 ... Eye drop container, 101 ... Container body, 102 ... Acceleration sensor, 103 ... Transmitter, 200 ... Small recording device.

Claims (4)

Based on the eye drop operation information detected by the eye drop operation detection unit that detects the operation of the eye drop container, and the input patient eye information, and an analysis unit that analyzes the eye drop situation and disease state of the patient,
The eye information is the thickness of the rim portion of the optic papilla of the fundus measured by OCT,
The analysis means obtains the relationship between the elapsed time from the start of instillation and the thickness of the rim portion of the optic papilla,
The analysis means, based on the relationship between the elapsed time from the start of the instillation and the thickness of the rim portion of the optic nerve head, predict the thickness of the rim portion in the future as a first predicted value,
The analysis means, based on the relationship between the elapsed time from the start of the eye drops and the thickness of the rim portion of the optic papilla, other eye drops different from the eye drops that have been instilled using the eye drop container. The eyedrop container monitoring system that predicts the thickness of the rim portion in the future when the above is used as a second predicted value. An eye drop container monitoring system for monitoring eye drops using an eye drop container,
A transmitting means for transmitting eyedrop movement information,
Eye-drop action recording means for recording the eye-drop action information transmitted from the transmitting means,
Acquisition means for acquiring the eyedrop movement information recorded in the eyedrop movement recording means,
The eye drop operation information acquired by the acquisition means, the input eye information of the patient, and an analysis means for analyzing the eye drop operation status of the patient based on the data of the number of times of the eye drops of the patient on a daily or monthly basis are provided. Then
The eye information is the thickness of the rim portion of the optic papilla of the fundus measured by OCT,
The analysis means obtains the relationship between the elapsed time from the start of instillation and the thickness of the rim portion of the optic papilla,
The analysis means, based on the relationship between the elapsed time from the start of the instillation and the thickness of the rim portion of the optic nerve head, predict the thickness of the rim portion in the future as a first predicted value,
The analysis means, based on the relationship between the elapsed time from the start of the eye drops and the thickness of the rim portion of the optic papilla, other eye drops different from the eye drops that have been instilled using the eye drop container. The eyedrop container monitoring system that predicts the thickness of the rim portion in the future when the above is used as a second predicted value. An eyedrop motion detection step of detecting the motion of the eyedrop container,
Based on the eye drop operation information detected in the eye drop operation detection step, and the input patient eye information, an analysis step for analyzing the eye drop situation and disease situation of the patient
Have
The eye information is the thickness of the rim portion of the optic papilla of the fundus measured by OCT,
In the analysis step, the relationship between the elapsed time from the start of instillation and the thickness of the rim portion of the optic papilla is determined,
In the analysis step, based on the relationship between the elapsed time from the start of the instillation and the thickness of the rim portion of the optic papilla, predict the thickness of the rim portion in the future as a first predicted value,
The analysis step, based on the relationship between the elapsed time from the start of the eye drops and the thickness of the rim portion of the optic papilla, other eye drops different from the eye drops that have been instilled using the eye drop container. A method for monitoring an eye drop container, which predicts the thickness of the rim portion in the future as a second predicted value in the case of using. A program that a computer reads and executes,
The computer is operated as an analyzing unit that analyzes the eyedrop situation and disease state of the patient based on the eyedrop operation information detected by the eyedrop operation detection unit that detects the operation of the eyedrop container and the input patient eye information. ,
The eye information is the thickness of the rim portion of the optic papilla of the fundus measured by OCT,
The analysis means obtains the relationship between the elapsed time from the start of instillation and the thickness of the rim portion of the optic papilla,
The analysis means, based on the relationship between the elapsed time from the start of the instillation and the thickness of the rim portion of the optic nerve head, predict the thickness of the rim portion in the future as a first predicted value,
The analysis means, based on the relationship between the elapsed time from the start of the eye drops and the thickness of the rim portion of the optic papilla, other eye drops different from the eye drops that have been instilled using the eye drop container. A program for eyedrop container monitoring that predicts the thickness of the rim portion as a second predicted value in the case of using.

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