JP6692372B2 - クレアチンプロドラッグ、その組成物、及びその使用方法 - Google Patents

クレアチンプロドラッグ、その組成物、及びその使用方法 Download PDF

Info

Publication number
JP6692372B2
JP6692372B2 JP2017552008A JP2017552008A JP6692372B2 JP 6692372 B2 JP6692372 B2 JP 6692372B2 JP 2017552008 A JP2017552008 A JP 2017552008A JP 2017552008 A JP2017552008 A JP 2017552008A JP 6692372 B2 JP6692372 B2 JP 6692372B2
Authority
JP
Japan
Prior art keywords
creatine
compound
substituted
disease
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017552008A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018502911A5 (enExample
JP2018502911A (ja
Inventor
ウィリアム エフ． ブルベイカー
ウィリアム エフ． ブルベイカー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmington Pharma Development
Original Assignee
Farmington Pharma Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmington Pharma Development filed Critical Farmington Pharma Development
Publication of JP2018502911A publication Critical patent/JP2018502911A/ja
Publication of JP2018502911A5 publication Critical patent/JP2018502911A5/ja
Application granted granted Critical
Publication of JP6692372B2 publication Critical patent/JP6692372B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/06—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2017552008A 2014-12-22 2015-12-22 クレアチンプロドラッグ、その組成物、及びその使用方法 Active JP6692372B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095295P 2014-12-22 2014-12-22
US62/095,295 2014-12-22
PCT/US2015/067283 WO2016106284A2 (en) 2014-12-22 2015-12-22 Creatine prodrugs, compositions and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020072408A Division JP7037597B2 (ja) 2014-12-22 2020-04-14 クレアチンプロドラッグ、その組成物、及びその使用方法

Publications (3)

Publication Number Publication Date
JP2018502911A JP2018502911A (ja) 2018-02-01
JP2018502911A5 JP2018502911A5 (enExample) 2018-12-13
JP6692372B2 true JP6692372B2 (ja) 2020-05-13

Family

ID=56128653

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017552008A Active JP6692372B2 (ja) 2014-12-22 2015-12-22 クレアチンプロドラッグ、その組成物、及びその使用方法
JP2020072408A Active JP7037597B2 (ja) 2014-12-22 2020-04-14 クレアチンプロドラッグ、その組成物、及びその使用方法
JP2022033882A Active JP7676338B2 (ja) 2014-12-22 2022-03-04 クレアチンプロドラッグ、その組成物、及びその使用方法
JP2025075259A Pending JP2025118733A (ja) 2014-12-22 2025-04-30 クレアチンプロドラッグ、その組成物、及びその使用方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020072408A Active JP7037597B2 (ja) 2014-12-22 2020-04-14 クレアチンプロドラッグ、その組成物、及びその使用方法
JP2022033882A Active JP7676338B2 (ja) 2014-12-22 2022-03-04 クレアチンプロドラッグ、その組成物、及びその使用方法
JP2025075259A Pending JP2025118733A (ja) 2014-12-22 2025-04-30 クレアチンプロドラッグ、その組成物、及びその使用方法

Country Status (8)

Country Link
US (3) US9617230B2 (enExample)
EP (2) EP3771709B1 (enExample)
JP (4) JP6692372B2 (enExample)
AR (2) AR103254A1 (enExample)
CA (1) CA2971729C (enExample)
ES (1) ES2832333T3 (enExample)
TW (3) TWI832450B (enExample)
WO (1) WO2016106284A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9617230B2 (en) 2014-12-22 2017-04-11 Farmington Pharma Development Creatine prodrugs, compositions and methods of use thereof
US11021501B2 (en) 2015-03-30 2021-06-01 Farmington Pharma Development Creatine phosphate analog prodrugs, compositions and methods of use thereof
WO2019109067A2 (en) * 2017-12-01 2019-06-06 Ultragenyx Pharmaceutical Inc. Creatine prodrugs, compositions and methods of use thereof
CN110746325A (zh) * 2018-07-24 2020-02-04 上海和辉光电有限公司 一种基于胍骨架的n型掺杂化合物及其应用
CN114419050B (zh) * 2022-03-31 2022-06-21 武汉大学 胃黏膜可视化程度量化方法、装置、终端及可读存储介质

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4915952A (en) 1987-02-27 1990-04-10 Alza Corporation Composition comprising drug, HPC, HPMC and PEO
US4786503A (en) 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
CA1340821C (en) 1988-10-06 1999-11-16 Nobuyuki Fukazawa Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
ATE131851T1 (de) 1991-07-19 1996-01-15 Uniroyal Chem Co Inc Zusammensetzungen zur verwendung von filmen auf saatgut
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5643909A (en) 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
US5451409A (en) 1993-11-22 1995-09-19 Rencher; William F. Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends
EP2327404A1 (en) 1994-11-08 2011-06-01 Avicena Group, Inc. Use of creatine or creatine analogs for the treatment of diseases of the nervous system
US5945125A (en) 1995-02-28 1999-08-31 Temple University Controlled release tablet
MY113429A (en) 1995-02-28 2002-02-28 Univ Temple Controlled release tablet containing swellable polyethylene oxide
US5824638A (en) 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
JPH11513671A (ja) 1995-10-11 1999-11-24 アヴィセナ グループ，インク． 糖代謝異常の治療のためのクレアチン類似体の利用
US5783212A (en) 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
IT1282650B1 (it) 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
US6008252A (en) * 1996-07-26 1999-12-28 Beale; Paxton K. Method for increasing muscle mass in a mammal
US6210710B1 (en) 1997-04-28 2001-04-03 Hercules Incorporated Sustained release polymer blend for pharmaceutical applications
GB9710699D0 (en) 1997-05-24 1997-07-16 Danbiosyst Uk Gastro-retentive controlled release system
US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
EP1003476B1 (en) 1997-08-11 2004-12-22 ALZA Corporation Prolonged release active agent dosage form adapted for gastric retention
US6090411A (en) 1998-03-09 2000-07-18 Temple University Monolithic tablet for controlled drug release
US6797283B1 (en) 1998-12-23 2004-09-28 Alza Corporation Gastric retention dosage form having multiple layers
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US20030008007A1 (en) 2001-04-23 2003-01-09 Jose Gutierrez-Rocca Release pharmaceutical construct for gastric retention
US20030013767A1 (en) 2001-07-13 2003-01-16 Samuel Bessman Method of treating weight loss using creatine
US20040219186A1 (en) 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
US6723340B2 (en) 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
EP1461019A2 (en) 2001-12-15 2004-09-29 Spherics, Inc. Bioadhesive drug delivery system with enhanced gastric retention
NZ533784A (en) 2002-01-03 2006-08-31 Smithkline Beecham Corp Novel pharmaceutical dosage forms and method for producing same
DE10221344A1 (de) 2002-05-14 2003-12-04 Hannover Med Hochschule Transgene Ratte und ihre Verwendung im Tiermodell für die humane Chorea Huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung
EP1556413A4 (en) 2002-05-17 2009-07-08 Esperion Therapeutics Inc METHODS AND COMPOSITIONS FOR TREATING ISCHEMIC REPERFUSION
US20040102525A1 (en) 2002-05-22 2004-05-27 Kozachuk Walter E. Compositions and methods of treating neurological disease and providing neuroprotection
GB0214013D0 (en) 2002-06-18 2002-07-31 Euro Celtique Sa Pharmaceutical product
US20060013876A1 (en) 2002-06-26 2006-01-19 Lohray Braj B Novel floating dosage form
US20040120983A1 (en) * 2002-12-23 2004-06-24 Philip Connolly Nutritional supplement
WO2005108370A1 (ja) * 2004-04-16 2005-11-17 Ajinomoto Co., Inc. ベンゼン化合物
US20060046962A1 (en) 2004-08-25 2006-03-02 Aegis Therapeutics Llc Absorption enhancers for drug administration
US20060045865A1 (en) 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US20070012105A1 (en) 2005-07-13 2007-01-18 Barnes-Jewish Hospital Method and apparatus for resistive characteristic assessment
US20070032750A1 (en) 2005-07-15 2007-02-08 Jeffrey Oster Muscle strength assessment system
WO2007146085A2 (en) 2006-06-06 2007-12-21 Xenoport, Inc. Creatine phosphate prodrugs, compositions and uses thereof
US20070281995A1 (en) * 2006-06-06 2007-12-06 Xenoport, Inc. Creatine analog prodrugs, compositions and uses thereof
US7683043B2 (en) 2006-06-06 2010-03-23 Xenoport, Inc. Creatine phosphate analog prodrugs, compositions and uses thereof
WO2008101310A1 (en) * 2007-02-20 2008-08-28 Multi Formulations Ltd. Creatine-fatty acids
US7319157B1 (en) 2007-02-20 2008-01-15 Multi Formulations Ltd. Creatine-fatty acids
US8426395B2 (en) 2008-05-30 2013-04-23 Northern Northern Innovations Holding Corp Preparations containing creatine and imino sugars
WO2010005692A2 (en) 2008-06-16 2010-01-14 E. I. Du Pont De Nemours And Company Insecticidal cyclic carbonyl amidines
AU2012312654B2 (en) 2011-09-19 2017-04-13 Gencia Corporation Modified creatine compounds
US9233099B2 (en) 2012-01-11 2016-01-12 University Of Cincinnati Methods of treating cognitive dysfunction by modulating brain energy metabolism
AR091857A1 (es) 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
EP2692719B1 (en) * 2012-07-30 2016-06-08 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Method for preparing creatine fatty esters, creatine fatty esters thus prepared and uses thereof
ITTO20121098A1 (it) * 2012-12-18 2014-06-19 Univ Degli Studi Genova Procedimento per sintetizzare derivati della creatina
WO2015069699A1 (en) * 2013-11-05 2015-05-14 Ultragenyx Pharmaceutical Inc. Creatine analogs and the use thereof
ITTO20131070A1 (it) * 2013-12-24 2015-06-25 Univ Degli Studi Genova Applicazione terapeutica di un derivato di creatina
US9617230B2 (en) 2014-12-22 2017-04-11 Farmington Pharma Development Creatine prodrugs, compositions and methods of use thereof
WO2016110822A1 (en) * 2015-01-09 2016-07-14 Universita' Degli Studi Di Genova Carboxylic biacyl creatine derivative, uses and method of synthesis thereof
US11021501B2 (en) 2015-03-30 2021-06-01 Farmington Pharma Development Creatine phosphate analog prodrugs, compositions and methods of use thereof

Also Published As

Publication number Publication date
WO2016106284A2 (en) 2016-06-30
US10344007B2 (en) 2019-07-09
US20160176829A1 (en) 2016-06-23
CA2971729C (en) 2024-02-20
TW202041504A (zh) 2020-11-16
US9617230B2 (en) 2017-04-11
CA2971729A1 (en) 2016-06-30
WO2016106284A3 (en) 2016-10-13
US20170342039A1 (en) 2017-11-30
JP2018502911A (ja) 2018-02-01
TWI779312B (zh) 2022-10-01
EP3771709B1 (en) 2024-03-20
TW201629011A (zh) 2016-08-16
AR103254A1 (es) 2017-04-26
TW202304854A (zh) 2023-02-01
AR122096A2 (es) 2022-08-10
TWI832450B (zh) 2024-02-11
JP2022078213A (ja) 2022-05-24
US11407722B2 (en) 2022-08-09
JP2025118733A (ja) 2025-08-13
JP7676338B2 (ja) 2025-05-14
JP2020128379A (ja) 2020-08-27
EP3771709A1 (en) 2021-02-03
EP3237391B1 (en) 2020-09-02
EP3237391A2 (en) 2017-11-01
TWI700270B (zh) 2020-08-01
ES2832333T3 (es) 2021-06-10
EP3237391A4 (en) 2018-10-03
US20190337909A1 (en) 2019-11-07
EP3771709C0 (en) 2024-03-20
JP7037597B2 (ja) 2022-03-16

Similar Documents

Publication Publication Date Title
US8202852B2 (en) Creatine phosphate analog prodrugs, compositions and uses thereof
JP7037597B2 (ja) クレアチンプロドラッグ、その組成物、及びその使用方法
US20070281995A1 (en) Creatine analog prodrugs, compositions and uses thereof
US20070281909A1 (en) Creatine phosphate prodrugs, compositions and uses thereof
JP2024009811A (ja) クレアチンプロドラッグ、組成物及びその使用方法
US11021501B2 (en) Creatine phosphate analog prodrugs, compositions and methods of use thereof
US20070281910A1 (en) Salicyl alcohol creatine phosphate prodrugs, compositions and uses thereof
US20070281983A1 (en) Creatine analog prodrugs, compositions and uses thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181102

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181102

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190805

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190808

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20191101

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191211

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200317

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200414

R150 Certificate of patent or registration of utility model

Ref document number: 6692372

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250