JP6668264B2 - 複数のレトロウイルス株における非対称標的部位を組み換えるための、十分に寛容化され高度に特異的なテーラーメイドリコンビナーゼ - Google Patents
複数のレトロウイルス株における非対称標的部位を組み換えるための、十分に寛容化され高度に特異的なテーラーメイドリコンビナーゼ Download PDFInfo
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| Application Number | Priority Date | Filing Date | Title |
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| EP14183277.4A EP2993229A1 (fr) | 2014-09-02 | 2014-09-02 | Recombinase bien toléré et très spécifique mise au point sur mesure pour recombiner des sites asymétriques voulus dans une pluralité de souches de rétrovirus |
| EP14183277.4 | 2014-09-02 | ||
| PCT/EP2015/069890 WO2016034553A1 (fr) | 2014-09-02 | 2015-09-01 | Recombinase bien tolérée et hautement spécifique conçue sur mesure pour recombiner des sites cibles asymétriques dans une pluralité de souches de rétrovirus |
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| JP2017526341A JP2017526341A (ja) | 2017-09-14 |
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| CN110914414A (zh) * | 2017-06-14 | 2020-03-24 | 德累斯顿工业大学 | 利用设计dna重组酶遗传改变基因组的方法与手段 |
| WO2021085580A1 (fr) * | 2019-10-31 | 2021-05-06 | 国立研究開発法人理化学研究所 | Polynucléotide et son utilisation |
| EP3831939A1 (fr) | 2019-12-06 | 2021-06-09 | Technische Universität Dresden | Fusion de recombinases spécifiques à un site pour une édition efficace et spécifique du génome |
| CN111304211B (zh) * | 2020-03-10 | 2020-12-01 | 无锡市第五人民医院 | Rhd-t268a突变体及其检测 |
| CN118234856A (zh) | 2021-11-15 | 2024-06-21 | 德累斯顿工业大学 | 用于有效且特异性基因组编辑的位点特异性重组酶 |
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| ATE317440T1 (de) | 1997-11-18 | 2006-02-15 | Pioneer Hi Bred Int | Neuartige methode zur integration von fremd-dna ins eukaryotische genom |
| US6890726B1 (en) | 1999-04-06 | 2005-05-10 | Oklahoma Medical Research Foundation | Method for selecting recombinase variants with altered specificity |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| GB0029375D0 (en) | 2000-12-01 | 2001-01-17 | Total Fina Elf | Substrate linked directed evolution (slide) |
| WO2005081632A2 (fr) | 2004-02-26 | 2005-09-09 | State Of Israel, Ministry Of Agriculture, Agricultural Research Organization | Enzymes, cellules et procedes de recombinaison specifiques de sites dans des sites asymetriques |
| US20060014264A1 (en) | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
| EP1942192A1 (fr) | 2007-01-08 | 2008-07-09 | Heinrich-Pette-Institut für experimentelle Virologie und Immunologie | Utilisation de la récombinase sur mesure dans le traitement des infection retrovirales |
| WO2009007982A1 (fr) | 2007-07-11 | 2009-01-15 | State Of Israel, Ministry Of Agriculture, Agricultural Research Organization | Région conservée du génome du vih-1 et utilisations de celle-ci |
| EP2576798B1 (fr) * | 2010-05-27 | 2016-04-27 | Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - | Recombinase mise au point sur mesure pour recombiner des sites asymétriques voulus dans une pluralité de souches de rétrovirus |
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| RU2016148309A3 (fr) | 2019-04-03 |
| US10150953B2 (en) | 2018-12-11 |
| AU2015310965B2 (en) | 2021-02-25 |
| PL3143136T3 (pl) | 2019-02-28 |
| EP3143136A1 (fr) | 2017-03-22 |
| EP3143136B1 (fr) | 2018-11-07 |
| US20170175091A1 (en) | 2017-06-22 |
| CN106852155A (zh) | 2017-06-13 |
| AU2015310965A1 (en) | 2016-12-15 |
| CA2951772C (fr) | 2022-12-13 |
| ES2710708T3 (es) | 2019-04-26 |
| RU2706194C2 (ru) | 2019-11-14 |
| RU2016148309A (ru) | 2018-10-03 |
| HUE040388T2 (hu) | 2019-03-28 |
| WO2016034553A1 (fr) | 2016-03-10 |
| CA2951772A1 (fr) | 2016-03-10 |
| JP2017526341A (ja) | 2017-09-14 |
| CN113699172A (zh) | 2021-11-26 |
| EP2993229A1 (fr) | 2016-03-09 |
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