JP6668205B2 - Method of manufacturing concave pattern mold and pattern sheet - Google Patents

Description

  The present invention relates to a concave pattern mold and a method for manufacturing a pattern sheet, and more particularly, to a concave pattern mold used for manufacturing a pattern sheet having needle-like convex portions and a method for manufacturing a pattern sheet using the concave pattern mold.

  As a method for administering a drug or the like from the surface of a living body, that is, skin or mucous membrane, a needle-like convex portion containing a drug and having a high aspect ratio (hereinafter, also referred to as “microneedle” or “microneedle”) is formed. A method of injecting a drug by inserting a needle-like convex portion into the skin using a percutaneous absorption sheet has been performed.

  The production of a percutaneous absorption sheet having needle-like protrusions is performed by filling a transfer pattern with a material for needle-like protrusions, drying, and curing using a mold (mold) having a transfer pattern formed thereon. ing. The percutaneous absorption sheet is manufactured by filling a liquid containing an expensive drug into the tip of the needle-shaped concave portion of the mold, and then applying a liquid containing no drug. By filling the tip of the transdermal absorption sheet with a drug, the drug can be effectively administered into the skin when the transdermal absorption sheet is inserted into the skin. Further, since the drug is expensive, the cost can be reduced by providing the drug only at the tip of the convex portion of the transdermal absorption sheet. In order to fill the needle-shaped concave portion with the liquid containing the drug, it is necessary to press the nozzle against the mold or to scrape the liquid supplied on the mold with a blade, and bring the nozzle or blade into contact with the mold. Have gone.

  Numerous molds with a transfer pattern have been proposed. For example, in Patent Documents 1 to 5 described below, when a pattern sheet is formed, a resin solution constituting the pattern sheet flows out of the mold. A mold provided with a frame or a step is described to prevent the fluid from flowing beyond a target place. By using a frame or a mold having a step, when a liquid containing no drug is applied to the surface of the mold, it is possible to prevent the liquid containing no drug from flowing off the mold.

JP-A-2006-67681 JP 2015-217043 A JP 2010-69253 A JP 2009-82207 A JP 2015-231476 A

  However, when the mold has a step, the nozzle or blade cannot sufficiently contact the mold surface when filling the needle-shaped concave portion with the liquid containing the drug. The mold is formed of a member having elasticity, and the step can be reduced by pressing, but it is not enough, so that the liquid containing the drug remains on the mold surface.

  In addition, when a liquid containing a medicine is supplied to a concave pattern mold having a flat surface, a step is provided by installing a frame, and when a liquid containing no medicine is supplied, the mold and the frame are accurately positioned. It was difficult. In addition, there is a problem that handling properties when setting the frame are poor.

  The present invention has been made in view of such circumstances, and even when having a step, when manufacturing a pattern sheet, a concave pattern mold in which no liquid residue occurs, and using this concave pattern mold An object of the present invention is to provide a method for manufacturing a pattern sheet.

  In order to achieve the above object, a concave pattern mold according to the present invention includes a needle-shaped concave array in which a plurality of needle-shaped concave portions are arranged in an array, and further, a plurality of needle-shaped concave arrays are arranged in an array. A concave pattern mold having a concave pattern, on the surface side where the concave pattern is formed, having a convex step around the area where the needle-like concave array is arranged, and the back side opposite to the front side Has a concave step at a position corresponding to the convex step.

  According to the concave pattern mold of the present invention, in the production of a pattern sheet, when supplying a liquid to the needle-shaped concave portion, even if the convex step portion is pressed by a liquid supply device such as a nozzle or a blade, the convex step portion is formed. By providing a concave step on the back surface side at a position corresponding to the portion, the convex step can be easily crushed. Therefore, it is possible to prevent the liquid from remaining on the surface of the concave pattern mold. Further, since an expensive drug can be contained only at the tip of the needle-shaped concave portion, all the drug can be absorbed into the skin, and no waste is caused.

  Furthermore, since the convex step portion returns to the original shape after the liquid supply device has passed, even when the liquid forming the sheet portion of the pattern sheet is supplied, it is possible that the liquid flows outside the convex step portion. Can be prevented. Therefore, a pattern sheet can be manufactured with a desired film thickness.

  In one aspect of the concave pattern mold according to the present invention, the material is preferably made of an elastomer resin or a silicone resin.

  In this embodiment, the material of the concave pattern mold is specified, and by using the above material as the material, when manufacturing the pattern sheet, it is possible to easily collapse the convex step portion by the liquid supply device. After the liquid supply device has passed, the convex step portion can be easily returned. Further, the filling of the liquid when manufacturing the pattern sheet can be performed with high accuracy. Furthermore, even if the pattern sheet is a drug, a pattern sheet that maintains safety can be manufactured.

  In one aspect of the concave pattern mold according to the present invention, the convex step portion preferably has a tapered shape narrowing toward the tip, and the concave step portion preferably has a tapered shape expanding toward the opening.

  According to this aspect, the convex step portion and the concave step portion are tapered so that the convex step portion can be easily crushed. Therefore, when the pattern sheet is manufactured, liquid can be prevented from remaining on the surface, and the liquid can be filled.

  In one aspect of the concave pattern mold according to the present invention, it is preferable that the taper angle of the tapered shape of the concave step is larger than the taper angle of the taper of the convex step.

  According to this aspect, by making the taper angle of the concave step portion larger than the taper angle of the convex step portion, the opening of the concave step portion can be widened. As a concave step portion. Therefore, when the pattern sheet is manufactured, liquid can be prevented from remaining on the surface, and the liquid can be filled.

  In one aspect of the concave pattern mold according to the present invention, it is preferable that the width of the convex step is narrower than the width of the concave step.

  According to this aspect, by making the width of the convex step portion smaller than the width of the concave step portion, it is possible to have a space wider than the convex step portion as the concave step portion. Therefore, when the pattern sheet is manufactured, liquid can be prevented from remaining on the concave pattern mold surface, and the liquid can be filled.

  In order to achieve the above object, a method for producing a pattern sheet according to the present invention includes a filling step of filling a solution in a needle-like concave portion of the concave pattern mold described above, and drying the solution to form a pattern sheet. And a peeling step of peeling the pattern sheet from the concave pattern mold.

  By manufacturing a pattern sheet using the concave pattern mold, the needle-shaped concave portions can be filled with a drug. Therefore, the manufactured drug can be effectively absorbed into the skin.

  Further, the convex step portion serves as a frame when applying the solution, and can prevent the solution from flowing beyond the convex portion. Therefore, independent molding and peeling can be performed for each patch by the convex step portion, and the pattern sheet can be manufactured without cutting after molding. Further, the thickness of the sheet portion of the pattern sheet can be the thickness of the convex step portion, and can be a desired thickness.

  According to the concave pattern mold of the present invention, since the concave step portion is provided on the back surface at a position corresponding to the convex portion of the concave pattern mold surface, when filling the needle-shaped concave portion with the liquid, the convex portion on the front side is formed. The liquid supply device can be brought into contact with the surface of the concave pattern mold by indenting the stepped portion. Therefore, there is no remaining liquid, and the drug can be concentrated on the needle-shaped concave portion. In addition, by manufacturing a pattern sheet using the concave pattern mold, the medicine can be concentrated on the tip of the needle, and the pattern sheet can be manufactured stably and at low cost. In addition, the convex step portion allows independent molding and peeling for each patch, and cutting after molding is unnecessary. Therefore, the number of steps can be reduced and defects such as cracks can be suppressed.

It is a flowchart showing the procedure of manufacturing a concave pattern mold. 1 is a schematic external view of an injection molding die. It is a flowchart showing the procedure of manufacturing a concave pattern mold. It is a flowchart showing the procedure of manufacturing a concave pattern mold. It is a flowchart showing the procedure of manufacturing a concave pattern mold. It is a flowchart showing the procedure of manufacturing a concave pattern mold. FIG. 5 is a process chart showing a procedure for manufacturing a concave pattern mold. It is a top view of a concave pattern mold. It is a bottom view of a concave pattern mold. It is the elements on larger scale of the concave pattern mold of another embodiment. It is the elements on larger scale of the concave pattern mold of another embodiment. It is the elements on larger scale of the concave pattern mold of another embodiment. It is a flowchart showing a manufacturing method of a pattern sheet. It is a flowchart showing a manufacturing method of a pattern sheet. It is a flowchart showing a manufacturing method of a pattern sheet. It is a flowchart showing a manufacturing method of a pattern sheet. It is a flowchart showing a manufacturing method of a pattern sheet. It is a flowchart showing a manufacturing method of a pattern sheet. It is a flowchart showing a manufacturing method of a pattern sheet.

  Hereinafter, a method for manufacturing a concave pattern mold and a pattern sheet according to the present invention will be described with reference to the accompanying drawings. In addition, in this specification, "-" is used in the meaning including the numerical value described before and after it as a lower limit and an upper limit.

<Manufacture of concave pattern mold>
A method of manufacturing a concave pattern mold (hereinafter, also referred to as a “mold”) will be described with reference to FIGS.

  First, as shown in FIG. 1, a mold 10 which is a reverse mold of a mold is prepared. On the mold 10, a convex pattern 12 which is an inverted shape of the concave pattern 50 of the mold 40 to be manufactured (see FIG. 7) is formed. In addition, since the mold 40 of the present embodiment has the convex step portion 44 on the surface of the mold 40 on which the concave pattern 50 is formed, the mold 10 has the concave portion 14 corresponding to the convex step portion 44. Is formed. The convex pattern 12 and the concave portion 14 are produced according to the shape of the mold to be produced. In the present embodiment, the needle-like convex portions 16 of the convex pattern 12 have a tapered shape toward the tip of the convex pattern 12. Examples of the tapered shape include a cone shape, a combination of a column shape and a frustum shape, a combination of a frustum shape and a frustum shape, and the like.

  FIG. 2 is a schematic external view of the injection mold 22, and FIG. 3 is a sectional view of the injection mold 22. As shown in FIGS. 2 and 3, the injection mold 22 is formed by disposing the upper mold 20 on the mold 10 shown in FIG. A cavity 24 is formed by clamping the mold 10 and the upper mold 20. The cavity 24 refers to a space filled with the resin.

  The upper die 20 is formed with a convex portion 26. The mold of the present embodiment has a convex step portion 44 on the surface side (hereinafter, also referred to as the front surface side) on which the concave pattern 50 is formed, and the back side opposite to the surface side on which the needle-shaped concave portion is formed. Has a concave step 46. The convex portion 26 formed on the upper die 20 forms a concave step 46 of the mold 40. The convex portion 26 is produced according to the shape of the concave step 46 of the mold to be produced.

  A gate 28 communicating with the cavity 24 is formed in the upper mold 20. The gate 28 serves as a resin injection port into the cavity 24 of the injection mold 22. The gate 28 is communicated with the injection molding machine via the resin flow pipe 30. As shown in FIG. 2, the resin flow path tube 30 has a widened portion 30 </ b> A that spreads in the width direction of the injection mold 22. It is preferable that the resin supplied from the injection molding machine via the resin flow path tube 30 be injected while being spread in the width direction of the injection mold 22 by the widening portion 30A. By supplying the resin while expanding it in the width direction of the injection molding die 22, the pressure of the resin injected into the cavity 24 can be reduced. In addition, by spreading the resin in the width direction, the resin can be supplied into the cavity 24 without leaving any space in the cavity 24.

  Next, as shown in FIG. 4, the resin 32 is supplied into the cavity 24. The supply of the resin 32 is performed by the injection molding machine (not shown) via the resin flow pipe 30 as described above. After injecting the resin 32 into the cavity 24 of the injection mold 22 and filling the cavity 24, the resin 32 is cured by heating to form the mold 40.

  Next, the mold 10 and the upper mold 20 that have been clamped are opened to release the mold from the injection mold 22. In the mold opening, as shown in FIG. 5, the mold 10 and the upper mold 20 are moved so as to be relatively separated from each other.

  After the upper mold 20 is peeled off, the mold 40 is peeled off from the mold 10 to have a concave pattern 50, a convex step portion 44 on the front surface side where the concave pattern 50 is formed, and a rear surface side thereof. A mold 40 having a concave step 46 is manufactured (FIGS. 6 and 7).

  FIG. 8 is a plan view of the mold thus manufactured, and FIG. 9 is a bottom view of the mold. As shown in FIG. 8, the surface of the mold 40 has a plurality of needle-like recessed arrays 42 in which a plurality of needle-like recesses 48 are arranged in an array. , A concave pattern 50 is formed.

  The convex step portion 44 is formed around a region where the needle-like concave portion array 42 is formed. By having the convex step portion 44, it is possible to prevent the forming material from leaking out of the mold 40 when manufacturing the pattern sheet.

  Further, as shown in FIGS. 7 and 9, the back surface of the mold 40 has a concave step 46 at a position corresponding to the convex step 44 on the front surface. In the production of a pattern sheet to be described later, when filling the needle-shaped recess 48 with a solution containing a drug, the solution containing the drug is supplied to the needle-shaped recess 48 of the mold 40 while pressing the mold 40 with a liquid supply device. By doing so, a solution containing a drug is supplied only to the needle-shaped concave portion 48 of the mold 40. By having the concave step 46 on the back surface side of the mold 40, the convex step 44 on the front surface side can be easily crushed. Therefore, it is possible to prevent a solution containing an expensive drug from remaining near the convex step portion on the surface side of the mold 40. In addition, since the medicine can be filled into the tip of the needle-shaped recess 48, the medicine can be effectively absorbed into the skin.

  The height of the convex step portion 44 is designed to be an optimum height in consideration of the concentration of the solution to be used, the thickness of the sheet portion of the pattern sheet to be manufactured, the rigidity of the mold, and the like. However, if it is too low, it is difficult to form a sheet portion when manufacturing a pattern sheet, and if it is too high, it becomes difficult to crush the convex step portion, which is not preferable. The height of the convex step can be 0.15 to 0.3 mm. In addition, the height of the concave step 46 is preferably the same as the height of the convex step 44 or higher than the height of the convex step 44 in order to easily crush the convex step. .

  Further, it is preferable that the width of the convex step portion 44 is wider than the thickness of the mold. By making the width of the convex step 44 larger than the thickness of the mold, the convex step 44 can be easily crushed.

  As a resin used for manufacturing the mold 40, an elastomer resin or a silicone resin can be used as a material. By using an elastomer resin or a silicone resin as a material of the mold 40, an elastic body can be provided to the mold, so that the convex step portion 44 can be easily crushed. In addition, since these materials have air permeability, it is possible to stably and quickly fill the needle-shaped concave portion 48 with a solution containing a drug.

«Another embodiment of concave pattern mold»
10 to 12 are enlarged views showing another embodiment of the convex step portion and the concave step portion of the concave pattern mold. In the mold 40 shown in FIG. 7 described above, the convex step portion 44 and the concave step portion 46 have a convex portion and a concave portion formed at an angle of 90 ° with respect to the surface of the mold 40.

  The mold 140 shown in FIG. 10 is different in that the shape of the convex step 144 and the concave step 146 is tapered. It is preferable that the taper angle α of the tapered shape be 90 ° or more and 130 ° or less. Note that the taper angle is the angle between the surface of the mold 140 and the side surface of the convex step 144 in the convex step 144, and the reverse of the mold 140 in the concave step 146. And the concave step 146.

11, the width L ₁ of the convex stepped portion 244 of the surface side of the mold 240, the point that is narrower than the width L ₂ of the rear surface side of the recessed step portion 246, it is different from the mold 40. The width L ₁ of the convex step 244 refers to the width of the convex step 244 in contact with the surface of the mold 240, and the width L ₂ of the concave step 246 is equal to the concave step. It refers to the width of the bottom surface of the concave portion of the portion 246. Comparing the width L ₁ and a width L _2, by decreasing the width L _1, it is possible to easily crush the convex stepped portion 244.

  In FIG. 12, the taper angle α of the convex step 344 is smaller than the taper angle β of the concave step 346. It is preferable that the taper angle α of the convex step portion 344 be in the above range. It is preferable that the taper angle β of the concave step portion 346 be 110 ° or more and 150 ° or less. By setting the taper angle α and the taper angle β within the above ranges, and making the taper angle β larger than the taper angle α, the opening of the concave portion of the concave step portion 346 can be widened. The step portion 344 can be easily crushed.

  By forming a convex step portion and a concave step portion as shown in FIGS. 10 to 12, a space wider than the convex step portion which is crushed by being pressed by the liquid supply device is provided on the back side of the mold. As a concave step portion. Therefore, the convex step portion on the front surface side of the mold can be easily crushed, and even if the liquid is supplied while pressing the mold by the liquid supply device, the needle-shaped concave portion 48 can be filled without remaining liquid. Note that, in FIG. 11, the description has been made of a mode in which the convex step portion and the concave step portion have a taper, but a mode without a taper may be adopted. Further, in FIG. 12, the width of the convex step is equal to the width of the concave step, but the width of the concave step may be widened.

≪Pattern sheet manufacturing method≫
Next, a method for manufacturing a pattern sheet will be described with reference to FIGS.

  FIG. 13 is a view showing a filling step of filling the concave pattern 50 of the mold 40 with a solution containing a drug, and FIG. 14 is a view showing a state in which the liquid supply device passes through the convex step 44.

  First, the needle-shaped concave portion 48 of the mold 40 is filled with a solution 62 containing a drug (filling step). As a filling method, as shown in FIG. 13, only the needle-shaped concave portion 48 can be filled by bringing the tip of the slit nozzle 60 into contact with the mold 40. Alternatively, a solution containing a drug may be applied to the mold by applying a solution containing the drug on the mold and bringing the blade into contact with the solution.

  In the mold 40 of the present embodiment, a convex step is formed on the surface of the mold 40 where the concave pattern 50 is formed so that the polymer solution (solution containing no drug) does not leak from the surface of the mold 40. It has a part 44. Further, the mold 40 includes a concave step 46 at a position corresponding to the convex step 44 on the front surface side on the back side of the mold 40. Therefore, as shown in FIG. 14, when filling the dissolving solution 62 containing the drug, when the slit nozzle 60 passes through the convex step portion 44, the slit nozzle 60 may crush the convex step portion 44. Thus, it is possible to prevent the solution 62 containing the drug from remaining on the surface of the mold 40. Therefore, an expensive medicine can be efficiently filled at the tip of the convex pattern of the pattern sheet to be manufactured. Further, by filling the tip of the convex pattern with a drug, the skin can be filled with the drug.

  After filling the needle-shaped concave portion 48 with the solution 62 containing a drug, the drug-containing layer 64 is formed in the needle-shaped concave portion 48 by drying and solidifying as shown in FIG. Drying and solidification can be performed by blowing air on the solution 62 containing the chemical supplied to the mold 40.

  Next, as shown in FIG. 16, a polymer solution 66 is applied by a dispenser onto the layer 64 containing a drug (filling step). In addition to coating by a dispenser, bar coating, spin coating, coating by spraying, and the like can be applied. Since the layer 64 containing the drug is solidified, the drug in the layer 64 containing the drug can be prevented from diffusing into the polymer solution 66.

  The applied polymer solution 66 is fixed by a convex step portion 44 formed on the surface side of the mold 40, and as shown in FIG. Will be supplied. As a result, the pattern sheet 70 to be manufactured is separated at the position of the convex step portion 44, so that after the pattern sheet 70 is manufactured, the pattern sheets can be manufactured individually without cutting.

  Next, as shown in FIG. 17, by drying and solidifying the polymer solution 66, a pattern sheet 70 composed of the drug-containing layer 64 and the polymer layer 68 is formed (step of forming a pattern sheet). Drying and solidification can be performed by blowing air onto the polymer solution 66 supplied to the mold 40. The moisture content of the pattern sheet 70 and the like are appropriately set. If the moisture content of the pattern sheet 70 becomes too low due to the drying, the pattern sheet 70 is hardly peeled off from the mold 40. Therefore, it is preferable to leave the moisture content in a state where the elasticity is maintained.

  After the polymer solution 66 is dried to form the pattern sheet 70, a peeling step of peeling the pattern sheet 70 from the mold 40 is performed (FIG. 18). The method of peeling the pattern sheet 70 from the mold 40 is not particularly limited. It is desired that the needle-shaped convex portion 72 does not bend or break during peeling. For example, a method is employed in which a sheet-like base material having an adhesive layer is formed on the pattern sheet 70, and then a suction cup is placed on the base material, and the substrate is pulled up vertically while sucking with air. be able to. By vertically pulling up, it is possible to prevent the needle-shaped convex portion 72 from being bent or broken during peeling. Moreover, you may peel off so that a base material may turn from an edge part. By peeling the pattern sheet 70 from the mold 40, the pattern sheet 70 can be manufactured as shown in FIG.

  It is preferable to use a water-soluble material as the material of the solution 62 containing the agent for forming the pattern sheet and the polymer solution 66. It is preferable to use a biocompatible resin as a material of the resin polymer contained in the solution. Examples of such resins include sugars such as glucose, maltose, pullulan, sodium chondroitin sulfate, sodium hyaluronate, and hydroxyethyl starch, proteins such as gelatin, and biodegradable polymers such as polylactic acid and lactic acid / glycolic acid copolymer. It is preferred to use. The concentration varies depending on the material, but is preferably a concentration at which the resin polymer is contained in the solution containing no drug in an amount of 10 to 50% by mass. The solvent used for dissolution may be any solvent other than warm water as long as it has volatility, and alcohols such as ethanol may be used. In a solution containing a drug, a drug to be supplied to the body can be dissolved together depending on the application. The polymer concentration of the solution containing the drug (when the drug itself is a polymer, the concentration of the polymer excluding the drug) is preferably 0 to 30% by mass.

  When using a water-soluble polymer (such as gelatin) as a dissolving solution, a water-soluble powder may be dissolved in water and a drug may be added after dissolution, or a water-soluble polymer may be added to the solution in which the drug is dissolved. Polymer powder may be added and dissolved. When it is difficult to dissolve in water, it may be dissolved by heating. The temperature can be appropriately selected depending on the type of the polymer material. However, it is preferable to heat at a temperature of about 20 to 40 ° C., if necessary. The viscosity of the solution of the resin polymer is preferably 200 mPa · s or less, more preferably 50 mPa · s or less, for the solution containing the drug. The dissolution liquid containing no drug is preferably 2000 mPa · s or less, more preferably 500 mPa · s or less. By appropriately adjusting the viscosity of the solution of the resin polymer, the solution can be easily injected into the needle-shaped concave portion of the mold. For example, the viscosity of the solution of the resin polymer solution can be measured with a capillary viscometer, a falling ball viscometer, a rotary viscometer, or a vibration viscometer.

  The drug contained in the solution is not limited as long as it has a function as a drug. In particular, it is preferable to select from peptides, proteins, diffusion, polysaccharides, vaccines, pharmaceutical compounds suitable for water-soluble low molecular weight compounds, or cosmetic ingredients.

  In FIGS. 13 to 19, the manufacturing method using the solution 62 containing the drug and the polymer solution 66 has been described, but the manufacturing method of the present invention is not limited to this. For example, it can be manufactured by filling a needle-shaped concave portion with one solution of a solution containing a drug. In addition, in the production using two liquids, the drying is performed after filling the dissolving solution 62 containing the drug, but the drying is not performed, and after filling the dissolving solution 62 containing the drug and the polymer dissolving solution 66, Drying may be performed.

  The shape of the needle-shaped convex portion 72 of the manufactured pattern sheet 70 is not particularly limited as long as the tip has a tapered shape. For example, the shape may be a cone or a pyramid such as a triangular pyramid or a quadrangular pyramid. Further, it can be formed by a tapered needle portion and a frustum portion connected to the needle portion.

  The height of the needle-shaped projections 72 of the projection pattern 74 is in the range of 100 μm or more and 2000 μm or less, and preferably 200 μm or more and 1500 μm or less.

  Since the projection pattern 74 of the pattern sheet 70 to be manufactured is a copy of the projection pattern 12 of the mold 10, the shape of the projection pattern 12 of the mold 10 is set to a desired shape. Can be formed in a desired shape.

10 Mold 12 Convex pattern 14 Concave part 16 Needle-like convex part 20 Upper mold 22 Injection mold 24 Cavity 26 Convex part 28 Gate 30 Resin channel tube 30A Spread part 32 Resin 40, 140, 240, 340 mold)
42 needle-shaped concave array 44, 144, 244, 344 convex step 46, 146, 246, 346 concave step 48 needle concave 50 concave pattern 60 slit nozzle 62 drug-containing solution 64 drug-containing layer 66 Polymer solution 68 Polymer layer 70 Pattern sheet 72 Needle-like projection 74 Projection pattern

Claims (4)

A concave pattern mold comprising a plurality of needle-like concave portions arranged in an array, and a plurality of the needle-like concave portion arrays having a concave pattern arranged in an array.
On the surface side on which the concave pattern is formed, a convex step portion is provided around a region where the needle-like concave array is arranged,
In the back side opposite to the surface side, it has a concave stepped portion at a position corresponding to the convex stepped portion,
The convex step portion has a tapered shape narrowing toward the tip, the concave step portion has a tapered shape expanding toward the opening,
The taper angle of the convex step portion is 90 ° or more and 130 ° or less, the taper angle of the concave step portion is 110 ° or more and 150 ° or less, and the taper angle of the taper shape of the concave step portion is A concave pattern mold that is larger than the taper angle of the tapered shape of the convex step portion .   The concave pattern mold according to claim 1, wherein the material is an elastomer resin or a silicone resin. The width of the convex stepped portion, a concave pattern mold according to the narrow claim 1 or 2 than the width of the concave step portion. A filling step of filling the needle-shaped concave portion of the concave pattern mold according to any one of claims 1 to 3 with a solution.
Drying the solution, forming a pattern sheet,
A method for manufacturing a pattern sheet, comprising: a peeling step of peeling the pattern sheet from the concave pattern mold.

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