JP6663203B2 - Livestock teat pack material - Google Patents

Description

  One of the serious diseases of dairy cows is mastitis. Mastitis is an infectious disease caused by the invasion of bacteria and other microorganisms into the udder through the nipple mouth and colonization, but due to the complex mechanism of its development, it cannot be eradicated yet and is important to the dairy industry. It is a disease that continues to cause significant economic losses. There are various types and symptoms of mastitis, but it is easy to find mastitis with so-called clinical symptoms such as redness, pain, swelling, fever, or appearance of milk souls in the breast. With the spread of treatment, it is decreasing worldwide. However, the absence of these clinical symptoms, but abnormalities such as an increase in the number of somatic cells are found when milk is examined.So-called latent mastitis has a significant economic loss, such as a decrease in milk production and milk quality. Despite this, its control is not progressing slowly.

In order to control such mastitis, the following globally recommended priority measures called “5 points” are as follows.
(1) Hygiene measures at milking facilities, including inspection and maintenance of milkers,
(2) disinfection of the nipple,
(3) treatment of clinical mastitis,
(4) Dry cow therapy (DCT),
(5) Selection of problem cattle (Non-Patent Documents 1, 2, and 3)
Among the measures listed above, teat disinfection of dairy cows is one of the most important preventive measures for mastitis control. Dodd et al. Of the United Kingdom developed and implemented a teat disinfectant in 1952, It has been used as a part of the milk quality improvement project since about 1940, and today it has a 40% penetration rate.

  Nipple disinfection, which is currently generally practiced, is a method of immersing the nipple in a dipping agent (aqueous disinfectant solution) after milking (so-called post-dipping), which sterilizes and disinfects mastitis-causing bacteria adhering to the nipple skin surface. A moisturizer is used to improve the condition of the nipple skin such as cracks and to suppress the growth of bacteria on the nipple surface, thereby preventing mastitis. Various post-dipping agents have been proposed (for example, Patent Document 1). Patent Document 2), and many products are commercially available on the market.

  However, in a study conducted by the National Institute for Research in Dairying in the United States, new infections in post-dipping dairy herds during the 12 months were reduced by 50%, but in terms of total breasts already infected. Only a 14% reduction. From this fact, it is reported that subclinical infections caused by existing bacteria have been sustained. That is, although this post-dipping reduces the rate of new infections caused by transmitted mastitis-causing bacteria, it cannot be expected to be as effective as expected with respect to the control effect on so-called environmental mastitis-causing bacteria. .

In other words, only the disinfection (post-dipping) after milking has a duration of effect (for example, when the nipple comes into contact with a cow bed or the like after application, the chemical is removed from the nipple and the effect is lost by 1-2 times). (Time) is relatively short, and the bactericidal effect is lost by the next milking, so that there is a limit to the effect on bacteria that cause environmental problems.




On the other hand, as a means for protecting the nipple of a dairy cow from mastitis-causing bacteria, a technique has been proposed in which the whole nipple of the dairy cow is masked to prevent bacteria and other microorganisms from entering the udder from the nipple mouth.

  For example, Patent Literature 3 states, "In the dry period of dairy cows, during about 2 to 9 days at the beginning of the dry period, which is susceptible to mastitis, and during about 2 to 9 days before parturition, Mastitis in dairy cows, characterized in that the nipple is immersed in a nipple sealant and the nipple is kept in a state of forming a thin film that closes the nipple opening, thereby physically preventing infection with mastitis-causing bacteria. Prevention method "(Claim 1). Further, Patent Document 3 discloses a nipple sealing agent for immersing a nipple mouth, a urethane rubber, a latex rubber, and an aromatic compound such as tetrahydrofuran, acetonitrile, trichloroethane, trichloroethylene, or methylene chloride, or an aromatic compound such as toluene or xylene. It describes a rubber material selected from butadiene resin, polyvinyl alcohol, liquid butyl rubber, liquid rubber, natural rubber, butyl rubber, nitrile rubber, chloroprene rubber, vinyl acetate rubber, and the like dissolved at a concentration of 5 to 15%.

  However, since the rubber-based material of Patent Document 3 requires time until the solvent evaporates to form a pack, if the cow rests lying down before the pack is formed after the pack is attached, the liquid is dissipated and the pack is not formed. Had. Further, when the rubber-based material is dried, harmful organic solvents such as acetonitrile and toluene are volatilized, which may impair the health of a human body or a dairy cow.

  Patent Document 4 discloses “a teat pack containing at least water, a calcium salt and an alginate, and having a viscosity before gelation of 5000 to 1.5 million mPa · sec”. It has been proposed that by adding an antibacterial agent such as iodine to the teat pack, the teat can be protected from mastitis-causing bacteria for a long period of time.

  However, in the teat pack described in Patent Document 4, it is described that a paste obtained by kneading a powder component comprising an alginate or a calcium sulfate with a solvent such as water is applied to the teat immediately before use. Have been. Calcium sulfate is insoluble in water, that is, a hydrophobic component, and it is extremely difficult to uniformly disperse it in a hydrophilic solvent such as water. In order to obtain a desired dispersibility, a great deal of labor and skill is required for the operator. In addition, there is a problem that the powder component is scattered around when kneading.

  Patent Document 4 discloses that the above problem is reduced by previously dispersing a powdery component composed of alginate or calcium sulfate in a hydrophilic solvent such as glycerin or propylene glycol. Even in this case, it is difficult to disperse calcium sulfate having a hydrophobic surface in a hydrophilic solvent, so that sedimentation and separation occur with time. As a result, in some cases, when used (when kneading with water), the dispersibility is rather deteriorated, so that kneading takes time or air bubbles are mixed in, so that the obtained teat pack is uniform. The properties and curability were reduced, the adhesion to the nipple was deteriorated, and the nipple was easily peeled off.

  As described above, in the teat pack, (a) the pack is instantaneously formed, adheres to the teat, does not peel off from the teat for a long time, particularly, the mouth of the teat is closed, (b) simple operation It is desired that the nipple can be packed.

JP-A-8-175989 JP-A-11-155404 JP-A-2000-41529 JP 2006-50911 A

Hiroshi Nagasawa, Representative of the Livestock Encyclopedia Editorial Committee, February 20, 1996, Livestock Encyclopedia, Yokendo Co., Ltd. Dairy Encyclopedia of Physiology, Breeding Techniques and Environmental Management, March 31, 2011 Kodansha Scientific Co., Ltd., New Livestock Handbook, September 10, 2006, Kodansha Co., Ltd.

  Against this background, the present invention provides a nipple pack which is mainly used to prevent nipples of livestock, mainly dairy cows, from mastitis. It is an object to provide a livestock teat pack material that is capable of being brought to life.

  In view of the above objects, as a result of earnest research, the present inventors have found that a pack formed from a polymer latex and a metal salt, an acid, or a mixture thereof can be instantaneously formed into a pack, and the pack mounting operation is simple. And found that the adhesion to the nipple was good, and completed the present invention.

That is, the present invention is a material for forming a pack that is directly adhered to the nipple of a domestic animal, and contains at least (A) a polymer latex (B) a coagulant that is a low-molecular inorganic coagulant ,
The (A) polymer latex is an emulsion in which a natural or synthetic rubber or a synthetic polymer is used as a dispersoid and dispersed in a dispersion medium containing mainly water.
The low molecular weight inorganic coagulant of the coagulant (B) is at least one selected from calcium chloride and magnesium chloride.
It is a teat pack material for livestock.

The nipple pack material for livestock of the present invention is an emulsion in which the polymer latex (A) is dispersed in a dispersion medium mainly containing water using the polymer latex as a dispersoid in order to increase the strength of the pack. It is.

In the livestock nipple pack material of the present invention , in order to enhance the strength of the pack, the low-molecular inorganic coagulant of the coagulant (B) is at least one selected from calcium chloride and magnesium chloride .

  The nipple pack material for livestock of the present invention is a kit for forming a pack to be brought into close contact with the nipple of livestock, wherein (i) a base containing at least (A) a polymer latex contained in a predetermined container, and (Ii) housed in a container different from the container, selected from the group consisting of at least (B) a low molecular inorganic coagulant, a high molecular inorganic coagulant, a synthetic high molecular coagulant, an acid, and a mixture thereof. A livestock nipple pack forming kit comprising a combination with a coagulant is preferable.

  The livestock teat pack material of the present invention is preferably a livestock teat pack forming kit in which the (ii) coagulant further contains (C) water and / or a water-soluble solvent.

  In one embodiment of the livestock nipple pack wearing of the present invention, it is preferable to use the above-mentioned livestock nipple pack material to generate a pack that is brought into close contact with the nipple.

  One embodiment of the veterinary nipple pack of the present invention comprises (i) (A) a base containing a polymer latex, and (ii) (B) a low molecular inorganic coagulant, a high molecular inorganic coagulant, Preferably, one of the flocculants selected from the group consisting of polymeric flocculants, acids, and mixtures thereof is applied to the teat of dairy animals, and then the other is applied to produce a pack that adheres to the teat. .

  The teat pack material for livestock of the present invention can easily and instantly prepare a teat pack having excellent uniformity (dispersibility) of each component. Further, the pack adheres to the teat and does not peel off from the teat for a long time. Further, since the formed pack has high elasticity, it can follow the contraction and expansion of the dairy cow nipple during the milking period. At the time of re-milking or in an emergency, it can be quickly removed without using any additional equipment or materials. Milking cows during the milking period can be effectively prevented from infectious diseases such as mastitis and are very promising.

  When the nipple pack material of the present invention is used, a pack which is in close contact with the nipple of a livestock can be obtained instantly by a simple method, and the pack does not peel off from the nipple for a long period of time. The pack is formed by aggregating latex particles by attaching one of the base material and the coagulation liquid to the nipple of the livestock and then attaching the other, and thus can be obtained by a very simple method.

  As a result, the vicinity of the nipple opening is completely sealed, and even if the nipple of the milking cow repeatedly shrinks and expands, the pack can follow the movement and maintain a state in which the pack is in close contact with the nipple. Thus, it is possible to reliably prevent the invasion of the nipple and the mouth.

  In addition, the nipple pack material of the present invention does not require a kneading operation immediately before use, and eliminates problems such as non-uniform nipple packs due to insufficient kneading and air bubble mixing.

  The nipple pack material of the present invention is obtained by adding (B) a low-molecular inorganic coagulant, a high-molecular inorganic coagulant, a synthetic high-molecular coagulant, an acid, and a mixture thereof to (A) a polymer latex in advance. The film can be formed by immersing the nipple in the (A) polymer latex in the middle of aggregation, but in order to allow a margin for the operation time, (i) a base containing at least (A) the polymer latex ii) A kit form comprising at least (B) a combination of a low molecular weight inorganic flocculant, a high molecular weight flocculant, a synthetic high molecular flocculant, an acid, and a flocculant selected from the group consisting of a mixture thereof. Is preferred.

Hereinafter, each component of the pack of the present invention will be described in detail.
(A) Polymer latex The polymer latex of the present invention is an emulsion in which a natural or synthetic rubber or a synthetic polymer is used as a dispersoid and dispersed in a dispersion medium containing water.

  "Latex" is originally a name given to a milky white aqueous emulsion collected from a natural rubber tree, and usually refers to natural rubber latex (latex in a narrow sense). However, a colloid sol using a rubber-based polymer such as synthetic rubber or synthetic resin as a dispersoid and an aqueous solution of various organic solvents or inorganic substances as a dispersion medium is also called latex (latex in a broad sense). An aqueous dispersion of a synthetic rubber produced using an emulsion polymerization method is called a synthetic rubber latex and may be distinguished from a natural rubber latex.An emulsion of a resin other than rubber is called a resin latex and is called a rubber latex. Sometimes they are distinguished. However, in recent years, the term "latex" has been used as a term encompassing all of natural rubber latex, synthetic rubber latex, and resin latex. Therefore, also in the present invention, "latex" is used in a broad sense hereinafter (Souichi Muroi: Chemistry of Polymer Latex, Polymer Publishing Association (1976)). In the present invention, it is preferable to mainly use water as a dispersion medium for dispersing the rubber-based polymer from the viewpoint of high safety and cost reduction.

  The type of the polymer latex of the present invention is not particularly limited, but an aqueous dispersion of a rubber-based polymer is preferable in order to increase the strength of the pack. A small amount of an organic solvent is acceptable as a dispersion medium, and an organic solvent of 10% by mass or less, preferably 5% by mass or less may be present. As the rubber-based polymer, for example, natural rubber, isoprene rubber, butyl rubber, butadiene rubber, ethylene-butadiene copolymer rubber, ethylene-propylene rubber, styrene-butadiene copolymer rubber, styrene-isoprene copolymer rubber, Urethane rubber, thiocol rubber, nitrile rubber, nitrile-butadiene copolymer rubber, chloroprene rubber, chlorosulfonated polyethylene rubber, chlorinated polyethylene rubber, acrylic rubber, vinyl acetate rubber, ethylene-vinyl acetate rubber, epichlorohydrin rubber, silicone rubber, polysulfide rubber, It is preferably at least one selected from aqueous dispersions of synthetic rubber such as polyether rubber, fluorine rubber, and polysulfide rubber or derivatives thereof. The rubber-based polymer derivative is, as shown below, a rubber-based polymer obtained by copolymerizing rubber-based polymers or a rubber-based polymer whose surface is modified with a reactive functional group such as a carboxyl group. Refers to things. Among the above-mentioned rubber-based polymers, when the surface has a negative charge, when a polyvalent metal compound or an acid (hydrogen ion) is added, the charge on the rubber-based polymer surface becomes medium. This is preferable because repulsion between the rubber-based polymers is eliminated and the rubber-based polymers adhere and aggregate faster. Further, among the above-mentioned rubber polymers, an aqueous dispersion of a rubber polymer having a large elongation and high strength so as to withstand the expansion and contraction of the livestock nipple is more preferable. Latexes composed of an aqueous dispersion of natural rubber or isoprene rubber are preferred from the viewpoints of easy aggregation and high elongation and high strength. Among natural rubbers or isoprene rubbers, those partially crosslinked in advance are preferred because they have higher strength. The above latex may be a mixture of two or more kinds, and may be copolymerized with each other. The form of the copolymerization may be any of random copolymerization, alternating copolymerization, periodic copolymerization, block copolymerization, and graft copolymerization. The structure of the polymer in the latex particles may be any of linear, branched, dendrimer, network, and cyclic. Also, latex particles whose surface is modified with a reactive functional functional group such as a carboxyl group can be used. In order to stabilize the latex particles, those to which various stabilizers such as ammonia and surfactants such as glycerin fatty acid ester and laurate ester are added can also be used. If necessary, a vulcanizing agent, a vulcanization accelerator, a vulcanization accelerator, a vulcanization retarder, a deterioration inhibitor (antioxidant, antiozonant, etc.), a processing aid (plasticizer, softener, etc.) , A tackifier, etc.), a dispersant, a creaming agent, a foaming agent, a heat-sensitive agent (zinc ammonium complex salt, polyvinyl methyl ether, etc.) and the like can also be used. The solid content concentration in the polymer latex is preferably 20% by mass or more and 90% by mass or less, and more preferably 30% by mass or more and 85% by mass or less.

When the solid concentration is less than 20% by mass, it takes a long time to form a pack, and the strength of the pack tends to be weak. On the other hand, when the solid content concentration is more than 90% by mass, the viscosity of the base becomes high and the applicability of the pack to the nipple tends to decrease.
(B) a flocculant selected from the group consisting of a low-molecular inorganic flocculant, a high-polymer flocculant, a synthetic high-polymer flocculant, an acid, and a mixture thereof; For example, a hydrophilic group (a sulfonic acid group, a hydroxyl group, or the like) of the emulsifier molecule is bonded to take a negative charge. The flocculant has a role of neutralizing the charge on the surface of the polymer fine particles constituting the polymer latex and aggregating the particles.
1. Low molecular inorganic coagulant (metal salt)
As the low molecular weight inorganic coagulant, various metal salts are exemplified. Among the coagulants, metal salts particularly effectively cause the coagulation of such negatively charged latex particles. In the present invention, a metal salt acting as a flocculant is, in a broad sense, defined as a compound in which an anion derived from an acid and a cation derived from a base are ion-bonded, and a neutralization reaction between an acid and a base, an acid and a basic oxide Reaction with an acid and a simple metal, a reaction between a base and an acidic oxide, a reaction between a base and a non-metal simple substance, a reaction between an acidic oxide and a basic oxide, a simple reaction between a non-metal simple substance and a metal It is a compound produced by a reaction and capable of ionizing in a latex dispersion medium to generate metal ions. The type of the metal salt is not particularly limited as long as it has the above-mentioned action, and all known salts can be used. Such metal salts include, for example, calcium chloride, magnesium chloride, iron chloride, tin chloride, aluminum chloride, titanium chloride, sodium chloride, potassium chloride, calcium sulfate, magnesium sulfate, zinc sulfate, aluminum sulfate, iron sulfate, zirconium sulfate. , Sodium sulfate, potassium sulfate, zinc oxide, magnesium oxide, aluminum oxide, iron oxide, titanium oxide, zirconium oxide, tin oxide, aluminum hydroxide, iron hydroxide, zirconium hydroxide, tin hydroxide, sodium hydroxide, hydroxide Metal salts such as potassium, zinc acetate, sodium acetate, potassium acetate, calcium lactate, zinc lactate, sodium lactate, potassium lactate, and potassium fluorotitanate are exemplified. These may be a mixture of two or more. Among these, a divalent metal salt is preferable because the latex particles are instantaneously aggregated, and among them, a calcium salt and a magnesium salt are more preferable.
2. Polymer-inorganic coagulant As the polymer-inorganic coagulant, polyaluminum chloride ([Al2 (OH) nCl6-n] m), polyaluminum sulfate ([Al2 (OH) n (SO4) 3-n / 2] m), polyiron chloride (III) ([Fe2 (OH) nCl6-n] m), polyiron sulfate (III) ([Fe2 (OH) n (SO4) 3-n / 2] m) and the like. You.
3. Synthetic polymer flocculant Examples of the synthetic polymer flocculant used as a flocculant in the present invention include polyacrylamide, polyethylene oxide, and urea-formalin resin as [nonionic] and polyanionic as [anionic]. Sodium acrylate (acrylamide-sodium acrylate copolymer), partially hydrolyzed polyacrylamide, sulfomethylated polyacrylamide, polyaminoalkyl (meth) acrylate, polyvinylpyridium halide, polydiallylammonium halide, and the like. Examples of the [cation type] include polyaminomethyl acrylamide, polyvinyl imidazoline, chitosan, epoxyamine type and the like. These have molecular weights of tens of thousands to millions, and the higher the molecular weight, the greater the charge.
4. AcidThe acid as an aggregating agent for aggregating the polymer fine particles constituting the polymer latex is not particularly limited in its type, but citric acid, lactic acid, acetic acid, malic acid, fumaric acid, maleic acid, etc. Tartaric acid, gluconic acid, succinic acid, propionic acid, butyric acid and the like are preferred. These may be a salt with a metal or a mixture of two or more.
[Additive]
In the pack material of the present invention, in addition to the components as the main components described above, various additives can be blended as needed. Examples of the additive include (C) water and / or a water-soluble solvent, a disinfectant / disinfectant, a filler, a thickener, a colorant, a fragrance, a preservative, and the like.
(C) Water and / or water-soluble solvent The teat pack material for livestock of the present invention comprises (i) a base containing a polymer latex, (ii) a low-molecular inorganic coagulant, a high-molecular inorganic coagulant, Preferably, it is stored as a kit comprising a flocculant selected from the group consisting of a molecular flocculant, an acid, and a mixture thereof. In addition, (C) water and / or a water-soluble solvent is added to (ii) a coagulant, and (B) a low molecular inorganic coagulant, a high molecular inorganic coagulant, a synthetic polymer coagulant, an acid and It is preferred to dissolve the flocculant selected from the group consisting of the mixture to prepare a uniform flocculant. By using a uniform flocculant, the uniformity of the composition of the pack is improved, and the adhesion can be further improved. The type of the water-soluble solvent is: (B) sufficiently dissolving a coagulant selected from the group consisting of a low-molecular inorganic coagulant, a high-molecular inorganic coagulant, a synthetic high-molecular coagulant, an acid and a mixture thereof; There is no particular limitation as long as it is not extremely harmful to the human body or livestock, and all known ones can be used. Among them, ethanol, propanol, butanol, acetone and the like are preferable. The blending amount of (C) water and / or a water-soluble solvent is not particularly limited, but (B) comprises a low molecular inorganic flocculant, a high molecular flocculant, a synthetic high molecular flocculant, an acid and a mixture thereof. The amount of (C) water and / or the water-soluble solvent to 100 parts by mass of the flocculant selected from the group is preferably from 150 parts by mass to 4000 parts by mass, more preferably from 200 parts by mass to 3000 parts by mass. preferable. The water and / or water-soluble solvent is added in an amount of 100 parts by mass of a flocculant selected from the group consisting of a low-molecular inorganic flocculant, a high-molecular inorganic flocculant, a synthetic high-polymer flocculant, an acid, and a mixture thereof. On the other hand, when it exceeds 4000 parts by mass, the aggregation of the latex may not occur instantaneously. On the other hand, the blending amount of water and / or the water-soluble solvent is 100 mass of a flocculant selected from the group consisting of a low molecular inorganic flocculant, a high polymer inorganic flocculant, a synthetic polymer flocculant, an acid and a mixture thereof. Parts, less than 150 parts by mass, a coagulant selected from the group consisting of a low molecular inorganic coagulant, a polymeric inorganic coagulant, a synthetic polymer coagulant, an acid, and a mixture thereof May not be sufficiently dissolved in water and / or a water-soluble solvent.

  A sterilizing agent may be used to impart a sterilizing effect to the pack material and to suppress an increase in the number of bacteria near the nipple opening. The germicidal disinfectant is not particularly limited as long as it can kill a wide range of harmful microorganisms such as various bacteria, fungi, and viruses that cause diseases such as mastitis.For example, an iodine compound, silver, copper, Metals and metal salts such as zinc, titanium and iron, tea leaf powder, hinoki powder, chitosan, benzalkonium chloride, benzethonium chloride, fatty acid esters such as caprylic acid monoglyceride and triclosan, isopropylmethylphenol, cetylpyridinium chloride, resorcinol, trichlorocarba Nide, halocarban, chlorhexidine, chlorhexidine hydrochloride, chlorhexidine gluconate, acrinol, sodium hypochlorite, hydrogen peroxide and the like can be exemplified. The germicidal disinfectant may be added to the substrate and / or the flocculant.

  Among them, iodine compounds and silver are preferred from the viewpoints of skin irritation to humans or livestock, sustained sterilization / disinfection effects, and cost. Examples of the iodine compound include iodine, popidone iodine, sodium iodate, potassium iodate, sodium iodide, potassium iodide, iodoform and the like.

  The blending amount of the germicidal disinfectant is not particularly limited, but is preferably contained in the base or coagulant in the range of 0.1 to 10% by mass.

  A filler may be used to adjust the physical properties of the pack. The filler may be added to the base and / or the flocculant. As the filler, it is preferable to use oxides of metals or metalloids such as silica and alumina, inorganic fluorine compounds such as potassium titanium fluoride and potassium silicofluoride, and particles of silicone resin.

  The amount of the filler is not particularly limited, but is preferably contained in the base or the coagulant in the range of 0.5 to 30% by mass.

  In addition, a thickener may be used to adjust the viscosity of the base and / or flocculant, and to improve the yield of the base and / or flocculant (liquid) on the nipple. The thickener may be used in combination with any one of the following inorganic thickeners and synthetic petroleum-based thickeners.

  Inorganic thickeners are generally compounds such as colloidal magnesium aluminum silicate, colloidal clay, which have been fume-treated or precipitated into particles having a large surface-to-size ratio.

  Synthetic petroleum-based water-soluble polymers are made by direct polymerization of the appropriate monomers. Representative examples of this monomer are vinyl alcohol, vinyl pyrrolidone, vinyl methyl ether, acrylic acid, methacrylic acid, acrylamide, ethylene oxide, and ethylene imine.

  A coloring agent may be used to color the pack and enhance the visibility of the pack. Although the type of the coloring agent is not particularly limited, titania particles, calcium carbonate, zinc oxide and the like can be mentioned as preferable examples, and among them, titania particles are more preferable.

  In order to improve rough skin and bilan on the nipple skin and near the nipple mouth, a moisturizing component, a cosmetic component, and a medicinal component may be added to the pack material. Preferred examples of the moisturizing component include sodium hyaluronate, glycerin, lanolin, sorbitol and the like. Preferred examples of the cosmetic component include castor oil and coconut fatty acid potassium. Preferred examples of the medicinal component include aloe vera leaf extract and eucalyptus oil.

[Preparation method and method of use]
(1) Preparation method of base and flocculant The base and (B) a low molecular inorganic flocculant, a polymer inorganic flocculant, a synthetic polymer flocculant, and an acid are added to (C) water and / or a water-soluble solvent. The method of preparing the coagulant when dissolved is not particularly limited, but can be prepared using a known stirring mixer. Here, as the stirring mixer, for example, a rotary container type mixing and kneading machine such as a ball mill, a ribbon mixer, a co-kneader, an internal mixer, a screw kneader, a Henschel mixer, a universal mixer, a Ladige mixer, a butterfly mixer, etc. A fixed container type mixing and kneading machine having a horizontal axis or a vertical axis can be used. Regarding the flocculant preparation, (B) a low molecular weight inorganic flocculant, a high molecular weight flocculant, a synthetic high molecular flocculant, and an acid (C) are relatively soluble in water and / or a water-soluble solvent. When it is high, a stirrer that does not apply a strong shearing force to a component to be dissolved or a solution in which the component is dissolved can be used. As such a stirrer, a portable stirrer equipped with various stirring blades, a solid stirrer, a side stirrer, a pipe stirrer and the like can be used. Furthermore, as for the preparation of the above-mentioned base and flocculant, two or more kinds of the above-mentioned various mixing and stirring machines can be used in combination.

(2) Pack production method The pack of the present invention comprises, for example, (i) a base containing at least (A) a polymer latex, and (ii) at least (B) a low molecular inorganic coagulant and a polymer inorganic coagulant. A flocculant selected from the group consisting of a synthetic polymeric flocculant, an acid, and a mixture thereof is prepared and formed by attaching one of the pieces to the nipple and then the other. After the base has been applied to the nipple, it is preferred to apply the flocculant to the nipple.

  Examples of the coating method (adhering method) include a dipping method, a brushing method, and a spraying method, but are not particularly limited. The immersion method is preferred.

  The viscosity of the base and the flocculant in the case of using the immersion method may be appropriately selected so that the nipple is easily immersed in each solution.

  When the immersion method is used, the viscosities of the base and the flocculant are values measured by a cone-plate viscometer at 23 ° C., and preferably in the range of 1 to 3000 mPa · s.

  The viscosity of the base and the coagulant when using the spraying method is preferably in the range of 1 to 1000 mPa · s from the viewpoint of easy spraying.

  When the immersion method is used, for example, the base and the flocculant are respectively placed in a cylindrical or cup-shaped container capable of accommodating nipples of livestock. Subsequently, the operation of moving the container in the direction of the base of the nipple (pulling up), immersing the nipple in the solution in the container, and then moving the container in the direction of the nipple tip (pulling down) is performed for each of the base and the flocculant. The immersion may be performed such that 10% or more, and preferably 20% or more, of the nipple is immersed in a base or a flocculant on a length basis, with the nipple length being 100%. The immersion time of the nipple is preferably 2 seconds or more in order to sufficiently adhere the base and the coagulant to the nipple.

  The material of the container is not limited as long as it is clean, and any material such as metal, ceramic, plastic, and paper can be used. Further, in order to reduce waste of the base and the flocculant, the container only needs to have a minimum internal volume necessary for attaching the base or the flocculant to the nipple. In the case of a cylindrical or cup-shaped container, an inner diameter of about 4 cm to about 8 cm and a height of about 2 cm to about 10 cm can be used. It is convenient to provide a mark inside the container so that a suitable amount of base or flocculant can be placed.

  In order to uniformly adhere the base and the flocculant to the teat, the speed of moving the container in the direction of the teat tip after dipping (the speed of pulling down) is preferably 10 to 100 mm / sec, and preferably 20 to 50 mm / sec. Is more preferred.

  With the base or flocculant well adhered to the nipple, the two materials are preferably attached to the nipple at a distance so that the other adheres to the nipple to form a pack.

  The ratio of the amount of base and flocculant adhering to the nipple (base / coagulant [parts by mass / parts by mass]) is not particularly limited, but is usually in the range of 0.5 to 2. Is preferred.

(3) Livestock nipple pack The dairy livestock pack of the present invention is characterized in that it is formed on the nipple of dairy livestock, for example, as described in (2) above. Dairy livestock packs can be used to protect the nipples of dairy livestock. Specifically, it can be used for protection against infectious mastitis, protection against environmental mastitis, protection from dirt and other external environmental factors. In the present invention, dairy livestock is particularly milking livestock, such as dairy cows, goats, and other livestock that are milked.

  Hereinafter, Examples 1 to 36, and Comparative Examples 1 to 7 for verifying the effects of the examples, and the like, will be described. A method for protecting nipples of livestock using two of a base and a flocculant according to the present invention. Will be specifically described, but the present invention is not limited to these examples.

  Abbreviations and "adhesion", "durability", "abrasion resistance", "bacteria count", and "" of the raw materials used in the teat pack production in Examples 1 to 36 and Comparative Examples 1 to 7 The evaluation method of “easiness of removing the pack” is as follows.

<Raw materials>
(A) Polymer latex natural rubber latex (NR): ULTRACOL manufactured by Redex Corporation, solid content concentration 62%, viscosity 50 mPa · s, minimum film formation temperature 10 ° C
Isoprene rubber latex (IR): Nipol ME manufactured by Zeon Corporation, solid content concentration 50%, viscosity 50 mPa · s, minimum film formation temperature 10 ° C
Butyl rubber latex (BUR), manufactured by JSR Corporation, JSR BUTYL065, solid content concentration 50%, viscosity 32 mPa · s, minimum film formation temperature 10 ° C
Butadiene rubber latex (BR), manufactured by JSR Corporation, JSR BR01, solid content concentration 50%, viscosity 45 mPa · s, minimum film formation temperature 10 ° C
Styrene butadiene latex (SB), manufactured by JSR Corporation, JSR SL552, solid content concentration 50%, polymerization ratio of styrene and butadiene 1: 4, viscosity 55 mPa · s, minimum film formation temperature 5 ° C
Urethane rubber latex (UR), manufactured by Daiichi Kogyo Seiyaku Co., Ltd., Superflex 460, solid content concentration 40%, viscosity 50 mPa · s, minimum film formation temperature 5 ° C
Nitrile rubber latex (NIR), manufactured by JSR Corporation, JSR N222SH, solid content concentration 50%, viscosity 85 mPa · s, minimum film formation temperature 5 ° C
Nitrile butadiene latex (NBR), manufactured by Zeon Corporation, Nipol 1561, solid content concentration 40%, viscosity 25 mPa · s, minimum film formation temperature 5 ° C
Chloroprene rubber latex (CR), CR-6500 manufactured by Redex Corporation, solid content concentration 50%, viscosity 100 mPa · s, minimum film formation temperature 10 ° C
Acrylic rubber latex (ACR): 2580, manufactured by Nissin Chemical Industry Co., Ltd., solid content concentration 45%, viscosity 50 mPa · s, minimum film formation temperature 10 ° C
Vinyl acetate rubber latex (VA): A23J1-F2 manufactured by Nissin Chemical Industry Co., Ltd., solid content concentration 45%, viscosity 2000 mPa · s, minimum film formation temperature 15 ° C
Ethylene vinyl acetate rubber latex (EVA): 4018, manufactured by Nissin Chemical Industry Co., Ltd., solid content concentration 61%, polymerization ratio of ethylene and vinyl acetate 1: 1, viscosity 300 mPa · s, minimum film forming temperature 10 ° C.
Silicone rubber latex (SIR): KM-860A manufactured by Shin-Etsu Chemical Co., Ltd., solid content concentration 60%, viscosity 350 mPa · s, minimum film formation temperature -15 ° C
Fluoro rubber latex (FR): E-3705S21R manufactured by Daikin Industries, Ltd., solid content concentration 50%, viscosity 300 mPa · s, minimum film formation temperature 10 ° C
The dispersion solvent for all of the above latexes is water. Further, the solid content concentration differs depending on the type of latex.

(B) a coagulant selected from the group consisting of a low molecular inorganic coagulant, a high molecular inorganic coagulant, a synthetic high molecular coagulant, an acid, and a mixture thereof: lactic acid: LA acetic acid manufactured by Wako Pure Chemical Industries, Ltd. AA Propionic acid manufactured by Wako Pure Chemical Industries, Ltd .: PA Fumaric acid manufactured by Wako Pure Chemical Industries, Ltd .: FA Maleic acid manufactured by Wako Pure Chemical Industries, Ltd .: MAA Citric acid manufactured by Wako Pure Chemical Industries, Ltd .: CA Wako Pure Chemical Industries, Ltd. Malic acid manufactured by the company: MA Tartaric acid manufactured by Wako Pure Chemical Industries: TA Gluconic acid manufactured by Wako Pure Chemical Industries: GA Succinic acid manufactured by Wako Pure Chemical Industries: SA Calcium chloride manufactured by Wako Pure Chemical Industries: CC Magnesium chloride manufactured by Kojun Pharmaceutical Co., Ltd .: MC Alum manufactured by Wako Pure Chemical Industries, Ltd .: AL manufactured by Wako Pure Chemical Industries, Ltd. (C) Water and / or water-soluble solvent water: WA
Ethanol: ET Wako Pure Chemical Industries, Ltd. Isopropanol: IPA Wako Pure Chemical Industries, Ltd. Butanol: BT Wako Pure Chemical Industries, Ltd. Acetone: AC Wako Pure Chemical Industries, Ltd. <Other components>
Alg-K: Potassium alginate (viscosity of 1% aqueous solution at 20 ° C. 300 mPa · sec) Alg-Na manufactured by Kimika Corporation: Sodium alginate (viscosity of 1% aqueous solution 300 mPa · sec at 20 ° C.) Calcium sulfate manufactured by Kimika Corporation: calcium sulfate dihydrate Products Wako Pure Chemical Industries, Ltd. Nipple Pack Composition Preparation Polymeric Organic Solvent Solution: Table 4
a: What melt | dissolved 12 mass parts of solute polyurethane rubber in 88 mass parts of solvent tetrahydrofuran.
b: 12 parts by mass of solute vinyl acetate dissolved in 88 parts by mass of solvent xylene.
c: What melt | dissolved 9 mass parts of solute butyl rubbers in 91 mass parts of solvent toluene.
d: What melt | dissolved 9 mass parts of solute butadiene rubber in 91 mass parts of solvent toluene.

<Evaluation method>
(1) Evaluation method of "adhesion" Dental silicone impression material ("Sofri Liner Tough Super Soft" manufactured by Tokuyama Dental Co., Ltd.) was placed in a mold having the shape of a teat of a dairy cow (inner diameter 3 cm, length 4 cm). After the impression material was hardened, the impression material was removed from the mold to produce a pseudo-nipple.

  In Examples 1 to 36, the base and the flocculant were each filled in a cup (a cylindrical container having an inner diameter of 6 cm and a length of 4 cm). Next, while holding the upper end of the simulated nipple, and in contact with the base material filled in the cup, a force was slowly applied to insert the 20% length of the simulated nipple tip and immediately pulled out. Subsequently, a pack was formed around the pseudo papilla by adhering (immersing) the entire pseudo papilla coated with the base material to the flocculant in the same manner. The film formation temperature was 37 ° C. close to the temperature of the nipple.

  In Comparative Example 1, the base was filled in a cup (a cylindrical container having an inner diameter of 6 cm and a length of 4 cm). Next, hold the upper end of the pseudo-nipple, and slowly apply force from a state in which the pseudo-nipple is in contact with the base material filled in the cup. The base was applied and left as it was.

  In Comparative Examples 2 to 5, 40 g of each of the organic solvent solutions a to d of the polymer compound for preparing a teat pack composition was filled in a cup (a cylindrical container having an inner diameter of 6 cm and a length of 4 cm). Next, hold the upper end of the pseudo-nipple, and slowly apply force from a state in which the pseudo-nipple is in contact with the solution filled in the cup, insert a 20% length of the pseudo-nipple tip, and immediately pull out the pseudo-nipple tip. The solution was applied and left as it was.

  In Comparative Examples 6 and 7, the powder component and the liquid component were weighed into a kneading cup such that the weight ratio became 1:15, and kneaded using a kneading spatula until a uniform paste was obtained. The resulting paste was filled into a cup. Next, while holding the upper end of the pseudo-nipple, and in contact with the paste filled in the cup, slowly apply force, insert until the entire nipple is hidden, immediately pull out, and harden the paste (leave for about 10 minutes). ).

The pack generated by the above-described method (pack generated at the tip of the pseudo-nipple) is left under the condition of 23 ° C. and 50% relative humidity with the nipple side of the pseudo-nipple hanging downward, and over time. The state of the teat pack was visually observed and evaluated according to the following evaluation criteria.
：: Good adhesion to the nipple and no drop-off.
Δ: A state in which adhesion to the nipple was impaired, but did not result in dropping. (The teat pack is moving down.)
×: The nipple pack was dropped from the nipple.

(2) Evaluation method of "durability" A dental silicone impression material ("Sofri Liner Tough Super Soft" manufactured by Tokuyama Dental Co., Ltd.) was placed in a mold having the shape of a teat of a dairy cow (inner diameter 3cmφ, length 4cm). After the impression material was hardened, the impression material was removed from the mold to produce a pseudo-nipple.

  The pack was left for 15 minutes, 1 hour, 1 day, 2 days, 3 days, and 4 days in an environment of a temperature of 23 ° C. and a relative humidity of 50% RH. The durability test shown below was performed on each of the packs. Assuming an actual pack use site, in the durability test, the surface where the pack collides was soil.

  The dummy nipple was set on a fatigue tester (E3000, manufactured by Instron) so that a load was applied from the central axis direction, and a load of 1 to 5 kgf / cm2 was applied. The median of the load was 3 kgf / cm2, and the amplitude was 2 kgf / cm2. The frequency was 1 Hz and the number of cycles was 100.

  After performing the durability test, the state of the pack was visually observed, and "durability" was evaluated based on the following evaluation criteria. In addition, when the evaluation of x was given by three days later, the subsequent test was not performed. In the table,-(no evaluation) is indicated.

Durability evaluation criteria:
：: No damage or lifting of the pack is observed.
Δ: Although the pack was partially damaged, the vicinity of the nipple opening was covered.
X: The whole is damaged or peeled.

(3) Evaluation method of “abrasion resistance” A silicone impression material for dental use (“Sofri Liner Tough Super Soft” manufactured by Tokuyama Dental Co., Ltd.) was placed in a mold having the shape of a teat of a dairy cow (inner diameter 3 cmφ, length 4 cm). After the impression material was cured, it was removed from the mold to produce a pseudo-papillary.

  As in the case of the evaluation of “adhesion”, a pack was formed around the pseudo-papillary. Subsequently, the pack was left for 15 minutes, 1 hour, 1 day, 2 days, 3 days, and 4 days in an environment of a temperature of 23 ° C. and a relative humidity of 50% RH. A wear test described below was performed on each of the packs.

  The pseudo-nipple is fixed with a jig with the nipple mouth up and fixed so that it does not move, and then placed on a scale, and reciprocated horizontally 50 times near the nipple mouth with a brush (hair length: 25 mm, hair material: nylon) Rubbed At that time, the amplitude was about 5 cm, and the load was about 1 kgf. After performing the abrasion test, the state of the pack was visually observed, and the “abrasion resistance” was evaluated based on the following evaluation criteria. In addition, when the evaluation of x was given by three days later, the subsequent test was not performed. In the table,-(no evaluation) is indicated.

Abrasion resistance Evaluation criteria ：: No exposure near the nipple opening was observed.
Δ: A part of the nipple opening is exposed.
×: The nipple and mouth are completely exposed.

(4) Evaluation method of "bacteria count" The pack after the durability test 4 days after the pack mounting in the above (2) "durability" evaluation was carefully peeled off so as not to stain inside. About 1 cm 2 of the portion corresponding to the nipple opening that had been packed was wiped off with a cotton swab (Promedia ST-25, manufactured by Elmex Corporation), and the cotton swab was immersed in 10 mL of physiological saline. 1 mL of the mixture was dropped into a medium (aerobic gold medium, 6400AC, manufactured by 3M) and cultured at 37 ° C. for 48 hours. After the culture, the number of colonies in the medium was counted, and assuming that one bacterium formed one colony, the number of bacteria in the above 10 mL of physiological saline was calculated from the number of colonies (the number of colonies × 10 = the number of bacteria). ). The determined number of bacteria was evaluated according to the following criteria. Generally, if it is less than 1000 pieces / cm 2, it can be determined that it is kept clean.

The number of external bacteria (the number of bacteria in the soil) varies, but is approximately 10,000 or more per cm 2.
○ Less than 1000 cells / cm 2: The number of bacteria is small, and the inside of the pack is kept clean.
Δ1000 / cm 2 or more and less than 10,000 / cm 2: The number of bacteria is slightly large, but smaller than the number of bacteria outside.
× 10000 / cm 2 or more: The number of bacteria is large, and the effect of reducing the number of bacteria by the pack cannot be confirmed.

(5) Evaluation method of “easiness of removing pack” A pack is generated in the same manner as in the above (1), and the pseudo papilla is suspended under the condition of 23 ° C. and 50% relative humidity with the nipple side hanging downward. Left for days. When the entire dummy nipple was wiped off with a cotton cloth (20 cm square), it was evaluated whether the pack could be removed cleanly.
： １: The pack can be peeled off neatly once.
Δ: The pack cannot be peeled off once, but can be peeled off by wiping it two or three times.
×: The pack cannot be peeled off even after wiping it two or three times.

Example 1
(A) A 40 g container of natural rubber latex was weighed and used as a base. Also, (B) 40 g of lactic acid was weighed and used as a flocculant.

  Using a base and a flocculant, a pack was formed and evaluated for "adhesion", "durability", "abrasion resistance", "number of bacteria", and "easiness of removing the pack".

Example 2 to Example 25
A pack was formed in the same manner as in Example 1 except that the compositions of the base and the flocculant were as shown in Tables 1 and 2, and "adhesion", "durability", "abrasion resistance", " The number of bacteria and the "easiness of removing the pack" were evaluated.

Example 26
A 40 g container of natural rubber latex was weighed and used as a base. The flocculant was prepared by adding 100 g of lactic acid to 500 g of water and stirring for 30 minutes. 40 g of the prepared flocculant was weighed into a container. Using a base and a flocculant, a pack was formed and evaluated for "adhesion", "durability", "abrasion resistance", "number of bacteria", and "easiness of removing the pack".

Example 27 to Example 36
A pack was formed in the same manner as in Example 26, except that the compositions of the base and the flocculant were as shown in Table 2, and "adhesion", "durability", "wear resistance", and "bacteria count" , And "easiness of removing the pack" were evaluated.

Comparative Example 1
A 40 g container of natural rubber latex was weighed and used as a base. A pack was formed using the base material and evaluated for "adhesion", "durability", "abrasion resistance", "number of bacteria", and "easiness of removing the pack".

Comparative Examples 2 to 5
40 g of an organic solvent solution of the polymer compound for preparing a teat pack composition was weighed and used as a base as it was. A pack was formed using the base material and evaluated for "adhesion", "durability", "abrasion resistance", "number of bacteria", and "easiness of removing the pack".

Comparative Example 6
20.0 g of sodium alginate and 20.0 g of calcium sulfate were respectively charged into a small mixer (a food mixer manufactured by Iwatani Co., Ltd.) and stirred for 5 minutes to obtain a uniform powder component. Further, 600 g of distilled water was prepared as a liquid component. A pack was formed using the powder component and the liquid component, and evaluated for "adhesion", "durability", "wear resistance", "bacteria count", and "easiness of removing the pack".

Comparative Example 7
A pack was formed in the same manner as in Comparative Example 6 except that the composition of the powder component was changed to that shown in Table 5, and “adhesion”, “durability”, “wear resistance”, “bacteria count”, and “ "Easy to remove the pack" was evaluated.

  Tables 1 to 5 show the compositions of the livestock nipple pack materials of Examples 1 to 36 and Comparative Examples 1 to 7. In addition, in Examples 1 to 36 and Comparative Examples 1 to 7, the evaluation results of “adhesion”, “durability”, “abrasion resistance”, “number of bacteria”, and “easiness of removing the pack” are shown in Tables 6 to 6. It is shown in Table 8.

  Examples 1 to 36 were adjusted so as to satisfy all the requirements of the present invention. In each case, a coating film having high adhesion, durability, and abrasion resistance was obtained. The bacteria count was low enough and the pack was easy to remove.

  On the other hand, Comparative Example 1 used (B) a flocculant selected from the group consisting of a low-molecular inorganic flocculant, a high-polymer inorganic flocculant, a synthetic high-polymer flocculant, an acid, and a mixture thereof. However, since it took about 30 minutes for the pack material to dry and form the pack, the pack was not formed at 15 minutes after the application of the pack composition, and during the durability test and during the durability test. The pack material was dissipated during the abrasion test and could not withstand the durability test and the abrasion test.

  Comparative Examples 2 to 5 are examples in which the organic solvent solution of the polymer compound for preparing a nipple pack composition was used as a base as it is according to Patent Document 3, but the pack material was dried to form a pack. However, it took about 30 minutes, and the pack was not formed at the time of 15 minutes after the application of the pack composition, and the durability test and the abrasion test could not be endured.

  Comparative Examples 6 and 7 are similar to Patent Literature 4 and are cases where a composition using an alginate was applied. However, many bubbles were mixed during kneading, and the viscosity of the kneaded product was not uniform. It was found that the pack was cracked in less than one day, and that the adhesion, durability and abrasion resistance of the pack were extremely low.

Claims (7)

A material for forming a pack that is directly adhered to the nipple of a livestock, comprising at least (A) a polymer latex (B) a flocculant that is a low-molecular inorganic flocculant ,
The (A) polymer latex is an emulsion in which a natural or synthetic rubber or a synthetic polymer is used as a dispersoid and dispersed in a dispersion medium containing mainly water.
(B) the low-molecular inorganic coagulant flocculant is at least 1 Tanedea Ru livestock teat pack material selected from calcium chloride or magnesium chloride. A kit for forming a pack that is directly adhered to the nipple of a livestock,
(I) a base containing at least (A) a polymer latex contained in a predetermined container, and (ii) a coagulant (B) a low molecular inorganic coagulant contained in a container different from the container, And a combination of
(A) a polymer latex of the base is an emulsion obtained by dispersing a natural or synthetic rubber or a synthetic polymer as a dispersoid in a dispersion medium mainly containing water;
(B) the low-molecular inorganic coagulant flocculant is at least 1 Tanedea Ru livestock teat pack forming kit selected from calcium chloride or magnesium chloride salt.   The livestock nipple pack forming kit according to claim 2, wherein the (ii) coagulant further comprises (C) water and / or a water-soluble solvent. A method for forming a teat pack for livestock, comprising using the livestock teat pack material according to claim 1 to produce a pack that is in direct contact with the teat. A method for preventing mastitis in dairy livestock, comprising using the livestock nipple pack material according to claim 1 to produce a pack that is directly adhered to the nipple. (I) a base comprising at least (A) a polymer latex, and
(Ii) A method of producing a pack which directly adheres to the nipple by adhering one of (B) a coagulant which is a low molecular inorganic coagulant directly to the nipple of the dairy animal, and then attaching the other. And
(A) a polymer latex of the base is an emulsion obtained by dispersing a natural or synthetic rubber or a synthetic polymer as a dispersoid in a dispersion medium mainly containing water;
(B) the low-molecular inorganic coagulant flocculant is at least 1 Tanedea Ru forming method of livestock teat pack selected from calcium chloride or magnesium chloride. (I) a base comprising at least (A) a polymer latex, and
(Ii) producing a pack that directly adheres to the nipple by adhering one of the flocculant, which is a (B) low molecular inorganic coagulant, directly to the nipple of the dairy animal, and then attaching the other. A method for preventing mastitis in dairy livestock,
(A) a polymer latex of the base is an emulsion obtained by dispersing a natural or synthetic rubber or a synthetic polymer as a dispersoid in a dispersion medium mainly containing water;
(B) the low-molecular inorganic coagulant flocculant is at least 1 Tanedea Ru mastitis prevention of dairy cattle selected from calcium chloride or magnesium chloride.