JP6646850B2 - Pain removal device - Google Patents

Description

  TECHNICAL FIELD The present invention relates to a pain removing device that conducts electric pulses to a human body or an animal body to relieve or remove pain and to spend more comfortable days.

Of the sensations generated from various parts of the human or animal body, pain is one of the important sensations for protecting oneself, but also causes inevitable suffering. Of course, the most important thing is to clarify the cause of the pain, remove the cause, and restore the patient to the original state of painlessness. It would be the thought of a person in agony.

  A major advance in relieving pain has been in the art of anesthesia. As a result, medical technology has advanced remarkably, and even an operation such as removal of an injured part can be performed by opening up the body without causing pain by anesthesia. The method is mainly performed by administering some drug, and in recent years, excellent pharmaceuticals with few side effects have been developed for the drug.

  However, in recent years, there are too many prescriptions of medicines by medical institutions, and various medicines are used heavily, so the effects of the medicines are weakened, not only the original effects can not be fully exhibited, but also the adverse effects There are also problems that worsen symptoms and cause new pain.

In addition, as the number of elderly people increases in recent years, more and more people complain of chronic pain, even if the pain in various parts does not make daily life impossible. Due to the occurrence of the problem, there is also a problem that the life that is supposed to be comfortable is hindered, and the quality of life itself deteriorates. Therefore, the ability to remove or relieve pain in a relatively easy and routine manner without the need for hospital visits or hospitalizations has become very important for geriatric care.

  In recent years, Oriental medicine has begun to be reviewed, and there has been an attempt to eliminate pain and various undesired symptoms of the body by physical methods without resorting to pharmaceuticals, and acupuncture and moxibustion have been widely performed. In addition, although it has not been generalized yet, there are some that try to provide analgesia and treatment by an electric method, and recently, it is increasingly used in acupuncture and moxibustion clinics.

  It is said that the analgesic and analgesic methods using an electric technique were first attempted by a Roman physician SCRIBONIUS LARGUS in about 46 years to try to remove the headache by sibireay (Non-Patent Document 1). In the 1950s, R. O. BECKER et al. Actively researched an electric treatment method. MELZACK and P.M. D. WALL published a new theory on pain mechanisms (Non-Patent Document 2)

This theory is based on the assumption that the impulses caused by the high-speed pain carried by the myelinated nerve fiber Aδ and the unmyelinated nerve fiber C are transmitted to the nerves located in the dorsal root of the spinal cord by the stimulation given to the thick nerve fiber Aβ rays. It closes the gate and suppresses the transmission of pain. It is called gate control theory, and is currently the basis of TENS (transcutaneous electrical nerve stimulation).

  The TENS includes a method of applying a stimulus at a high frequency (high frequency) and a method of applying a stimulus at a low frequency (low frequency) (Non-Patent Document 3). It is said that the high frequency immediately reduces pain and the low frequency stimulates the release of endogenous opioids, an effect that lasts a longer time for pain relief.

  However, it is not clear what this frequency is most effective, and although various frequency pattern studies are being conducted, it is still in a state where it can be said that it is still effective. Absent. Patent Literature 1 discloses a method of using a method of dividing a generally-known bulk waveform, that is, a high-frequency waveform at a low frequency, and applying it to an affected part with a frequency of 1 kHz or less, because electric shock is accompanied.

  In Patent Document 2, two frequencies of several hundred Hz to 1200 Hz and two frequencies of several Hz to several tens of Hz are provided, and a pulse of several Hz to several tens of Hz is inserted into the output of a frequency pulse of several hundred Hz to 1200 Hz. A method for obtaining a healing effect while minimizing the irritating feeling is disclosed.

Also, in Patent Document 3, by alternately switching a low-frequency pulse and a high-frequency pulse and applying the pulse to the living body, the pulse group also stimulates the living body during the high-frequency pulse period in which muscle contraction can be suppressed. It has the effect of relieving pain and reducing muscle fatigue.

JP-A-2003-135607 Patent 3757625 JP 2010-57804A R. MELZACK, P.M. D. WALL SCIENCE Vol. 150, no. 3699, P971-979 (1965) W. A. ALM, L.A. S. WEIL J. AMERICA. PODIATRY. MEDICAL. ASSO. Vol. 69, no. 9, P537-542 (1979) Physiotherapy Vol. 34, no. 4, P198-201 (2007)

  The conventional method of removing pain by electric pulse is to promote depolarization of nerve fiber cells regardless of high frequency and low frequency, and to obtain various effects such as pain suppression and recovery from fatigue by the power. there were. The depolarization effect has been developed in various forms up to now, supported by the gate control theory, and TENS is one of them.

All the sensations, such as pain and hot cold, are transmitted from the peripheral nerves of the body to the spinal cord, and the brain determines what stimulation it is. FIG. 8 shows how the stimulus and the excitement occur, and FIG. 7 shows the mechanism by which it occurs.

In FIG. 8, (a) shows the voltage applied inside and outside the cell on the vertical axis, and the time elapsed on the horizontal axis. In FIG. 8, the states that occur separately are superimposed on each other to compare the magnitudes of the electric pulses applied to the cells. (B) shows how the intracellular potential changes by the voltage pulse of (a), and the numbers 1 to 4 in (b) represent 1 of (a). ~ 4.

The potential in the cell is assumed to have a value of about −100 mV to −70 mV in a resting state, that is, a state without stimulation, and is usually kept constant. However, for some reason, the potential of 1 shown in FIG. When a pulse is applied to the cell, the potential inside the cell changes toward the positive side as indicated by 1 in (b). This is called depolarization, but when the stimulus does not exceed a certain level, the potential does not change much and the potential returns to the original resting state.

However, as the potential of the stimulus shown in FIG. 8A rises to 2 or 3, the potential in the cell also rises, and when it rises to 4, the potential in the cell rises to the critical point shown in FIG. When the voltage reaches A and reaches this value, the potential in the cell suddenly rises greatly to the positive side as shown in 4 of (b). This is referred to as firing, which indicates that the cell has been excited. This excited state decreases with the end of the pulse shown in (a) 4 and returns to the original -100 mV resting state.

FIG. 7 shows this electrical change more specifically than the cell configuration. In FIG. 7, reference numeral 701 denotes a hydrophilic phosphorus compound, 702 denotes a hydrophobic hydrocarbon, and a pair thereof is a phospholipid 703. Two of these phospholipids 703 are joined in an opposite pair to form a cell membrane 704.

  An ion channel 705 made of a protein is formed in the cell membrane 704 so as to be interrupted, and Na ions, K ions, and the like can pass between them. 706 indicates the inside of the cell, and 707 indicates the outside of the cell.

  In order to consider the electrical state when a voltage is applied to the inside and outside of the cell, what is shown in an equivalent circuit is 708, which is a parallel configuration of a resistance component 709 and a capacitor component 710. ing. With respect to the voltage applied to the cell membrane 704, the cell membrane 704 can be regarded as a capacitor component 710 and the ion channel 705 as a resistance component 709 because the cell membrane 704 is insulative.

The voltage (potential) shown in FIG. 8A indicates a value applied to the cell membrane 704, and is considered to cause a temporary capacitive current. On the other hand, the firing state exceeding the critical point A in FIG. 8B occurs when the capacitive current or voltage triggers and Na ions flow into the cells. Whether or not Na ions flow into cells and ignite or excite is determined by whether or not the voltage applied to the cell membrane reaches a certain limit, and whether or not this excitement is reached by exceeding a critical point. It is decided, and this is the state of existence. In addition, what triggers firing or not is a capacitive current or voltage generated by a negative voltage on the outside of the cell membrane and a positive voltage on the inside of the cell membrane.

  The Na ions flow into the cells, and the excited cells apply potential to the cells in the nerve fiber, causing the cells in the nerve fiber to ignite and excite. It travels to the brain. FIG. 9 shows a state in which the excitement 902-1 is transmitted through the nerve fiber 901 in a manner of 901-2 and 902-3.

As shown in FIGS. 7 and 8, it is the inflow of Na ions into the cells that causes the intracellular potential to largely swing to the plus side, and the potential generated by the inflow causes the stimulation. A positive potential is applied inside and a negative potential is applied outside to the cell membrane of the adjacent site 904 on the nerve fiber 901 in the direction of travel, thereby causing an outward current.

The potential of the adjacent portion 904 gradually increases from 1 to 4 as shown in FIG. 8A, and reaches the critical point A as shown in FIG. In this way, the excitement is transmitted from 902-1 to 902-2 and from 902-2 to 902-3 in the same nerve fiber 901.

Many anesthetics currently in use block ion channels and stop the flow of Na ions into cells. Excitation does not occur unless Na ions flow in, and the excitement does not propagate through nerve fibers. Therefore, pain can be temporarily suppressed. However, on the other hand, TENS and other electrical stimulators that try to reduce pain are those that excite nerve fiber Aβ and try to close the pain gate, and the effect is still remarkable. There were not enough achievements and the effects were unknown.

  Therefore, the present invention seeks to provide a novel method of relieving pain, which is not a method based on the gate control theory conventionally used, and to prevent an initial capacitive current leading to excitement and to prevent nerve fibers from being excited. It is intended to eliminate the excitement transmitted through or to stop transmitting the excitement.

  Excitement is usually caused by depolarization, as described above. This process is initiated by a capacitive outward current, thereby leading to an increase in the intracellular potential and a full-fledged excitement by the influx of Na ions from the critical point.

  Therefore, the present invention is intended to suppress a capacitive outward current before a nerve cell or a pain-generating cell reaches the next excitement so as to prevent the cell from reaching a firing point. In other words, a positive potential is applied to the outside of the cell, and a negative potential is applied to the inside of the cell, thereby causing the cell to become hyperpolarized and prevent the process from reaching the firing point of the excitation.

  In FIG. 9, (a), (b), and (c) show how excitation is generated and transmitted by depolarization. In (d), a positive potential is artificially applied to the outside of the cell membrane, Shows a case where a negative potential is applied to the inside of. In other words, the excitement is transmitted to 902-1, -2, and -3, and transmitted to the next state as shown in (d). However, the fire does not occur and the capacitive potential is changed as indicated by the change in the potential indicated by 903. The rise will return to its original state of rest.

Therefore, the effect of the excitation does not reach the nerve cells in the direction of the progress of the excitation, and a state occurs in which the transmission of the excitation in the nerve fiber is interrupted. In other words, the pain information is not transmitted to the brain, and the pain information is not entered, so that the person does not feel the pain.

  As a method of artificially applying a positive potential to the outside of the cell membrane and a negative potential to the inside of the cell membrane, it is generally considered that an electrode is inserted into a nerve fiber, and a positive voltage is applied outside and a negative voltage is applied inside. It's a good thing, except that the nerve fibers are generally very thin, except when the nerve fibers are very thick, like the squid used in experiments by Nobel scholars Hodgkin and Huxley at Cambridge University. Have difficulty.

Therefore, as a means for solving the problem, a property that a high-frequency pulse can pass through a cell and a property that a low-frequency pulse cannot pass through a cell are used. FIG. 10 conceptually shows the state of voltage pulses inside and outside a cell when the present invention is carried out.

In FIG. 10, 1001 indicates extracellular, and 1002 indicates intracellular. The intracellular 1002 and extracellular 1001 are surrounded by a cell membrane 1003, which is covered with an insulating film and partially made of a protein through which ions can pass as shown in FIG. The electrical equivalent circuit is shown by 708 in FIG. 7, but is a parallel circuit of a resistance component 709 and a capacitance (capacitor) component 710.

Since the resistance component of the cell membrane is very large, low-frequency pulses including direct current cannot pass through the cell. However, a pulse having a frequency higher than a certain level can be passed.

10A in FIG. 10A indicates a low-frequency pulse, and 1005 indicates a high-frequency pulse. The high-frequency pulse 1005 passes through the inside of the cell 1002, but the low-frequency pulse 1004 can pass through the extracellular 1001 but does not enter the inside of the cell 1002.
For this reason, as shown in FIG. 10B, the extracellular 1001 has a pulse 1006 obtained by adding a low-frequency pulse 1004 oscillating to the plus side, a low-frequency pulse 1004 and a high-frequency pulse 1005 oscillating to the minus side. Coexist, and become a positive state as a whole.

On the other hand, the inside of the cell 1002 is in a state of only a high-frequency pulse swinging to the minus side, and is in a minus state. The low-frequency pulse and the high-frequency pulse are partially accumulated inside the cell 1001, and a pulse 1006 oscillating to the positive side, which has been increased in frequency, enters the cell, but this pulse eventually cancels out inside and outside the cell. Will fit.

By the action of the low-frequency pulse 1004 and the high-frequency pulse 1005 passing through the intracellular 1002 and extracellular 1001, the cell wall becomes positive on the outside and negative on the inside, and a capacitive current is generated, causing the cell to become hyperpolarized. Suppress the depolarization of the cell so that it does not reach an excitable state.

The transition to hyperpolarization due to each pulse suppresses the excitement of cells that are going to be excited, acts on nerve fibers that are trying to transmit excitement, and acts to prevent transmission of excitement. That is, as a result, the pain information reaching the brain is stopped, and the pain is removed or alleviated.

As a means of the present invention, since a high-frequency pulse oscillating to the negative side and a low-frequency pulse oscillating to the positive side flow in synchronization, the intracellular 1002 has a negative pulse, and the extracellular 1001 has a positive pulse. It becomes dominant and a capacitive current flows from outside the cell into the cell, creating a hyperpolarized state of the cell.

Therefore, in order to transmit the excitement as information in the previous stage, the gradually increasing potential of the depolarized state in the nerve fiber cells sedated at a stretch and could not reach the excitement, and the excitement It is impossible to move on to the inflow of a certain Na ion, and information is not transmitted through the nerve fiber.

Then, there is a problem of what frequency is appropriate as a plus-side pulse and a minus-side pulse. FIG. 11 shows the frequency dependence of the electrical conductivity in the living tissue. A hatched portion 1101 in the figure shows how the conductivity of the living tissue changes according to the frequency of the applied pulse, and a hatched portion 1102 shows the conductivity of the intracellular fluid and the external fluid. I have. Intracellular fluid and extracellular fluid have high conductivity, and blood that plays a dominant role in their conductivity has been measured at 4 mS / cm when the conductivity is 1 MHz or less, with little change.

From FIG. 11, it can be seen that the conductivity 1101 of the living tissue is lower than the conductivity of the intracellular and extracellular fluids in the region 1103 of 1 kHz or lower, and the conductivity is higher in the region 1104 of 100 kHz or higher. Therefore, it is considered that an electric pulse of 100 kHz or more is less affected by the cell membrane as an insulator, and the electric pulse passes through the cell membrane.

On the other hand, the electric pulse having a frequency of 1 kHz or less has a conductivity smaller than the conductivity of the intracellular and extracellular fluids. Therefore, the electric pulse is affected by the insulating cell membrane and passes through the cell membrane rather than through the cell membrane. Is thought to be easier and will not enter the cells.

Therefore, it is considered that the negative voltage pulse passing through the cell is desirably 100 kHz or more, and the positive voltage pulse is desirably 1 kHz or less. However, if the positive voltage pulse has an extremely low frequency of about several Hz, a problem arises in that the required current cannot enter the body due to the insulation of the skin stratum corneum, so a relatively high pulse of about 1 kHz is used. It is also possible to adopt a method of setting the frequency to about several Hz in the form of a burst pulse configured as one lump.

The present invention generates a capacitive current from inside a cell to outside a cell by sending a negative pulse having a high frequency passing through the cell and a positive pulse having a low frequency that cannot pass through the cell to the human body, Cells become hyperpolarized, inhibit the excitement of the cells from exceeding the critical state, do not cause a rapid inflow of Na ions into the cells, and excite the cells causing pain or cells in nerve fibers Stop pain and create a condition where pain transmission does not occur.

As described above, the pain relieving device according to the present invention having the above-described means is not based on the conventional gate control theory, but sends a high-frequency negative pulse and a low-frequency positive pulse to the body. In the initial stage of cell excitement, hyperpolarization is performed without depolarization to prevent firing leading to excitement, soothing painful cells and excitement of nerve fibers in the state of pain transmission. It blocks movement midway, and can be expected to have a very high pain control effect.

  Further, since the low-frequency pulse of the low positive potential of the present invention employs a low frequency including a burst pulse state, an endogenous opioid can be emitted. In particular, by setting the frequency of the pulse on the positive potential side to about 1 to 10 Hz, a sedative substance such as β-endrophin or enkephalin is released into the brain, and a long-lasting analgesic effect can be expected.

  In summary, the pulse applied to the body from the positive and negative electrode pads has the effect of preventing the excitation of nerve cells and damaged cells at the moment of applying voltage to the electrode pads, resulting in a high immediate pain control effect . Further, by setting the low-frequency pulse of the positive potential to a relatively low frequency, the release of opioids in the brain occurs, and the pain suppression effect continues for a long time even after the pulse input is stopped. That is, the present invention exerts a tremendous effect in suppressing or alleviating pain.

1 is a first embodiment of a pain removing device according to the present invention, and is a diagram showing a schematic arrangement of external parts and internal electronic components. It is a 1st structural example of the voltage pulse output from the 1st Example of the pain removal device of this invention. It is a treatment example performed by the first and second embodiments of the pain removing device of the present invention. It is a 2nd example of a structure of the voltage pulse output from the 1st Example of the pain removal device of this invention. FIG. 2 is a view showing a second embodiment of the pain removing device of the present invention, showing an external appearance and a schematic arrangement of internal electronic components. It is a 1st structural example of the voltage pulse output from the 2nd Example of the pain removal device of this invention. It is a structural diagram of a cell (a) and an equivalent circuit (b). FIG. 3 is a diagram showing a process (a) in which cells are excited by stimulation and a voltage (b) applied to a cell membrane. FIG. 7 is a diagram showing a state in which the excitation is transmitted through the nerve fiber (a), (b), (c) and a state in which the excitation is artificially stopped (c). It is the figure which showed the conduction | electrical_connection (a) and the existence state (b) of the electric pulse of this invention inside and outside the cell. 4 is a graph showing the frequency dependence of the conductivity of a living cell and the intracellular and extracellular fluids.

  The present invention seeks to eliminate or alleviate pain by applying a high-frequency pulse having a pulse whose potential fluctuates from near 0 to a negative value and a relatively low-frequency pulse whose potential fluctuates positively from near 0 to the body. The present invention will be disclosed in the following embodiments with specific configurations.

FIG. 1 shows an external view of a pain removing apparatus according to an embodiment of the present invention and an arrangement of internal electronic components. In the figure, reference numeral 101 denotes a case, in which electronic components and a dry battery 102 are housed. Reference numerals 103, 104, and 105 denote adhesive electrode pads. An electrode pad (P +) of 103 applies a positive pulse to the electrode pad, and an electrode pad (P-) of 104 applies a negative pulse to the body. (G) gives 0 level which is ground.

Although the dry battery 102 is used in the present invention, any power source that can be used may be used. For example, a household AC power supply may be used as a power supply. However, in that case, an AC-DC conversion circuit for newly converting the voltage from AC to DC is required. It is also possible to use a secondary battery to allow external charging, but in that case, a circuit for protection and stabilization is required for charging.

The power output from the battery 102 is converted into a constant voltage by the amplification stabilization block 107 and the voltage can be adjusted by the variable resistor 110. With this variable resistor, the voltage can be gradually increased from the off state, and in the present invention, the plus pulse can be changed from 0 to 20V and the minus pulse can be changed from 0 to -20V.

In the amplification stabilizing block 107, the voltage can be changed only to the positive side, so that the voltage inversion block 108 is provided to change the voltage to the negative side. These positive and negative voltages are pulsed according to a command from the control block 109 and output to the electrode pads 103 and 104.

  In this embodiment, a display block 106 for displaying what kind of pulse is output is provided. However, simply, for example, some variations are conceivable, such as notifying the strength and pulse speed with an LED or the like. Switching between the strength and the pulse speed is performed by a tact switch 115. In the drawing, 111 is a resistor, 112 is a ceramic capacitor, 113 is an electrolytic capacitor, 114 is a coil, and 116 is a semiconductor element.

FIG. 2 shows voltage pulses output from the electrode pad (P +) 103, the electrode pad (P-) 104, and the electrode pad (G) 105 shown in FIG. The electrode pad (P +) 103 outputs a positive pulse 201 having a low frequency, the electrode pad (P-) 104 outputs a negative pulse 202 having a high frequency, and the electrode pad (G) 105 outputs a ground level 203. Have given.

In this embodiment, the pulse output from the positive electrode pad (P +) 103 is configured to be a 1 Hz burst pulse in which pulses of 5 Hz, 50 Hz, 250 Hz, 1 kHz and 2 kHz are collected, and the negative electrode pad is formed. The pulse output from (P-) 104 is always at a constant 100 kHz. In FIG. 2, when 100 kHz is displayed, the pulse becomes too fine, and therefore, the pulse is expressed only as an image whose outline can be understood.

  In this embodiment, the pulse duty uses a constant value of 0.5. When considering how to suppress nerve cell excitation, the pulse duty is also very important. As already shown in FIG. 10, it takes about 2 milliseconds for the excitement to occur and to calm down. Moreover, since the time required for the excitation to ignite is a fraction of that, a relatively high voltage is applied so that the inside of the cell becomes negative and the outside becomes positive during that period, so that depolarization does not occur. There is a need.

This duty is considered to be an important parameter for further enhancing the effect of the present invention, but the situation differs depending on each part of the body, and there is a problem between the plus side pulse and the minus side pulse, Future clinical data is needed.

  FIG. 3 shows an actual treatment example of the present embodiment. Reference numeral 301 denotes a pain site. The cells at the pain site are already in an excited state and transmitting pain. The electrode pads are as shown in FIG. 1, 103 is a plus electrode pad (P +), 104 is a minus electrode pad (P-), and 105 is a zero potential electrode pad (G).

  The plus-side electrode pad (P +) 103 and the minus-side electrode pad (P-) 104 are attached on the dermatome L5 passing through the pain site 301. The zero potential electrode pad (G) 105 is attached to the sole of the foot. The method of applying these electrodes should also be determined according to each symptom, and this example shows only one example.

  According to this embodiment, the effect of pain relief appears at the moment when a voltage is applied to the body from each electrode pad, and after a while, endogenous opioids are released into the brain. Pain relief lasts longer.

  In addition, since such a procedure is only a task of applying electrode pads, it can be performed by yourself, so if urgent pain such as gout occurs and you can not move and you can not cope with it, The pain removing device according to the present invention can alleviate pain quickly, and then can perform actions such as movement, so that it is possible to immediately shift to full-scale specialist treatment.

  FIG. 4 shows the form of the pulse output to the body from the electrode pads 103P + and P− of the electrode pads 104 by changing the microcomputer program in the control block 109 shown in FIG. This is an example, and is a second configuration example of the voltage pulse.

  In the second pulse configuration example of this embodiment, as shown in FIG. 4, when the plus side pulse 401 changes from the high voltage state to the ground level 402, the minus side pulse 403 also stops the pulse output. , At the ground level 402.

  By temporarily stopping the pulse in this way, the body becomes less fatigued and more sensitive to the pulse than when a continuous pulse is applied. Thereby, the effect of suppressing pain also increases, and a more effective pain suppressing effect can be created.

FIG. 5 shows a schematic arrangement of electronic components of a pain removing apparatus according to a second embodiment of the present invention. This embodiment is configured by adding some electronic circuits to the first embodiment, and the same components as the first electronic circuit are denoted by the same reference numerals. Also, electronic circuit blocks that are newly added but perform the same operation are indicated by dash numbers.

In this embodiment, a variable resistor 110-2 and a voltage amplification stabilizing block 107-2 are added to the first embodiment. By adding the variable resistor 110-2 and the voltage amplification stabilizing block 107-2, the magnitude of the voltage of the minus pulse and the magnitude of the voltage of the plus pulse can be individually changed.

  FIG. 6 shows the configuration of the voltage pulse output from the second embodiment of the present invention. In the pulse configuration shown in the first embodiment, the magnitude of the positive voltage and the minus While the magnitude of the voltage becomes a predetermined value and both are simultaneously changed by the variable resistor 110, in the present pulse configuration, the magnitudes can be individually changed.

  In the second configuration of the voltage pulse of the first embodiment shown in FIG. 4, when the plus voltage pulse is lowered to the ground level, the minus voltage pulse is also stopped at the ground level. When the plus-side voltage pulse 601 stops at the ground level 602, the minus-side pulse 603 stops at the minus level 604 opposite to the ground level.

  By arranging the pulse in this manner, the position of the electrode pad to be attached is devised so that the position between the on-state 601 of the plus pad (P +) 103 and the off-level 604 of the minus pad (P-) is determined. Thus, an apparently large potential difference appears, and in this region, a TENS-like effect appears greatly.

  The pain part has different physical constitutions, sizes, and volumes depending on each part such as an elbow, a waist, and a knee, and the electric conductivity, the electric capacity, and the like are not the same. Therefore, the voltage and the current also need to be applied differently depending on the location. In particular, the magnitudes of the minus pulse and the plus pulse are important, and it is important to set both to the most appropriate voltage ratio in order to cause cell hyperpolarization.

  In the present embodiment, the ground level 605 of the pulse on the negative side is not negative and is shifted to the positive side. However, even in such a case, the variable resistor 110 on the positive side and the variable resistor Since the resistor 110-2 can individually change the magnitude of each of the plus and minus, the potential difference between the inside and outside of the cell can be maintained as it should be by increasing the plus side potential.

  Also, it is very meaningful to set the ground level of the plus side pulse and the ground level of the minus side pulse individually, and by doing so, a constant voltage difference is always generated in the cells. By moving the positive and negative sides in the negative direction, the transition to hyperpolarization is facilitated, and the effect of calming the excited cells and stopping the transmission of pain is increased.

  In the present embodiment, since the plus side pulse and the minus side pulse can be individually changed, not only is it possible to promote intracellular hyperpolarization, but also by devising a place where the electrode pads 103 to 105 are attached. At the same time, it becomes possible to depolarize the thick nerve cell Aβ, and it is possible to alleviate pain by closing the pain gate.

  As described above, in the present invention, a high-frequency pulse having a pulse whose electric potential oscillates from near 0 and a relatively low-frequency pulse whose electric potential oscillates positively from near 0 are applied to the body. It has the effect of calming down the cells that are the cause of pain, suppressing the excitation of nerve fibers that transmit pain information, and preventing the transmission of pain.

Therefore, the pain signal sent to the brain is extremely reduced, and the pain is alleviated and alleviated. This action has immediate effects and promotes the production of internal opioids in the brain, so that pain relief lasts longer and reduces the quality of life caused by pain in daily life. is there.

By using the pain removing device of the present invention, pain can be alleviated and removed, and in daily life, the pain can be dealt with. It is not necessary and can be used as a simple home health care method. The pain relieving device according to the present invention does not need to use expensive drugs every time like a medicine, and can be used repeatedly for a very long time until the battery is exhausted, so that it can be used widely as a home medical device. There is.

101 case 102 dry cell 103 electrode pad (P +)
104 electrode pad (P-)
105 electrode pad (G)
106 Display block 107 Amplification stabilization block 108 Positive / negative inversion block 109 Control block 201 Positive voltage pulse 202 Minus voltage pulse 203 Ground level

Claims (3)

There is an electronic circuit portion that generates a positive voltage with respect to the ground potential (0 potential), and an electronic circuit portion that generates a negative voltage with respect to the ground potential (0 potential) by inverting the positive voltage. Then, positive and negative voltage pulses with respect to 0 potential are generated by three or more electrode pads of positive and negative including at least the ground potential (0 potential), and the negative voltage pulse has a frequency higher than that of the positive voltage pulse. Pain relief device characterized by high pain The frequency of the positive voltage pulse is to pair the cell surrounded by the body fluid to form a body, is set so that no current flows in said cell, whereas the frequency of the negative voltage pulse, said cell The pain removing device according to claim 1, wherein the device is also set so that a current flows. The pain removing device according to claim 1, wherein the frequency of the negative voltage pulse is 100 kHz or more, and the positive voltage pulse is 1 kHz or less.