JP6644666B2 - Microneedle array puncture device and microneedle array puncture set - Google Patents

Description

  The present invention relates to a microneedle array puncturing device and a microneedle array puncturing set, and more particularly to a microneedle array puncturing device and a microneedle array puncturing set for puncturing skin without touching the microneedle array.

  In recent years, functional sheets on which high aspect ratio structures such as microneedles are formed have attracted attention. In the field of medical technology, a needle array sheet having microneedles, which are needle-shaped protrusions, formed on the surface has been proposed as a transdermal absorption sheet for efficiently administering a drug to the body through the skin. Generally, by pressing the microneedle array against the skin and inserting the needle-shaped protrusion into the skin, the drug in the needle-shaped protrusion is delivered into the skin.

  When the microneedle array is pressed against the skin, a needle-like puncture device called an applicator can be used to puncture the needle-like convex portion easily and with good reproducibility. As such a puncture device, Patent Literature 1 discloses a telescopic spring for providing a driving force, a magnetic force-responsive tablet tip in which microneedles are constructed in an array form, and a magnetic force-responsive tablet tip which can be detachably attached to a magnet to control a collision force. A microneedle array comprising a movable part having projections and depressions, and an outer cylinder that holds the movable part and raises the movable part and then rotates the irregularities formed by the movable part to be fixed on the upper wall surface. A tip dispensing device is described.

JP 2014-83199 A

  When the microneedle array is taken out of the packaging container, there is a concern that the needle-shaped protrusions may be inadvertently touched and contaminated or damaged. Also in the device described in Patent Literature 1, when the microneedle array is mounted on the device, there is a possibility that the needle-shaped protrusion is contaminated or damaged. Further, when the microneedle array after puncturing is discarded, there is a concern that the microneedle array may come into contact with the microneedle array to which the bodily fluid is attached.

  The present invention has been made in view of such circumstances, and can press the microneedle array with a constant force, take out the microneedle array sheet from the packaging container, puncture, holding, a series of processes of disposal, An object of the present invention is to provide a device for puncturing a microneedle array and a set for puncturing a microneedle array that can be performed without touching a needle-shaped convex portion.

  In order to achieve the above object, a microneedle array puncturing device according to the present invention includes an outer cylinder having an outer cylinder opening at one end and a first through hole on the side opposite to the outer cylinder opening, and an outer cylinder. The inner cylinder opening in the same direction as the outer cylinder opening, the plunger holding section on the side opposite to the inner cylinder opening, and the plunger holding section having a second through hole. A suction unit that sucks the microneedle array; and a support unit that supports the suction unit. The support unit moves the first through hole and the second through hole so that the suction unit moves inside. A plunger movable in the cylinder, a spring wound around the support portion, provided between the outer cylinder and the suction portion, and biasing the suction portion toward the outer cylinder opening. One of the plunger holding portions is a magnet, the other is a magnetic material, and the inner cylinder is When stored in the barrel, the force and the plunger holding portion and the suction portion attract each other, when the spring were compared, and the urging force for urging the suction unit, a large biasing force.

  ADVANTAGE OF THE INVENTION According to the microneedle array puncturing device of this invention, the adsorption | suction part which adsorb | sucks a microneedle array can be urged | biased in the direction of an outer cylinder opening part between a spring and an outer cylinder. Then, by pressing the outer cylinder against the puncture target, the suction portion, that is, the microneedle array can be punctured into the puncture target by a spring. In addition, since the force for puncturing the microneedle array is an urging force of the length of the spring corresponding to the height of the outer cylinder, it can be pressed with a constant force.

  Further, when the plunger holding portion of the inner cylinder and the suction portion of the plunger are in contact with each other by magnetic force, the inner cylinder is maintained in a state of protruding from the outer cylinder. When adsorbing the microneedle array with the suction section, the tip of the inner cylinder is arranged so as to surround the microneedle array, and the outer cylinder is pressed toward the microneedle array, so that the adsorption section of the plunger is moved to the microneedle array. Therefore, the microneedle array can be reliably sucked by the suction section.

  Further, the urging force for urging the suction portion of the spring urges the suction portion toward the opening of the outer cylinder, so that when the outer cylinder is pressed toward the microneedle array, the inner cylinder moves in the opposite direction to the suction portion. The suction part moves away from the plunger holding part of the inner cylinder. When the inner cylinder is housed in the outer cylinder, the spring increases the urging force of the spring to bias the adsorber, compared to the force between the plunger holder of the inner cylinder and the adsorber of the plunger. The plunger holding portion and the suction portion can be prevented from being attracted and coming into contact with each other from the state where the plunger is stored. Therefore, when piercing the microneedle array into the puncture target, the inner cylinder can be punctured without applying a force opposing the magnetic force between the plunger holding portion and the suction portion, so that no extra force is applied. Puncture can be performed. When the inner cylinder is housed in the outer cylinder, the biasing force of the spring is larger than the force between the plunger holding portion and the suction portion, but the inner cylinder is manually moved out of the outer cylinder opening, for example. By moving the plunger, the plunger holding portion and the attracting portion can be easily attracted by magnetic force. Thereby, the microneedle array puncturing device can be used repeatedly.

  In one aspect of the device for puncturing a microneedle array according to the present invention, the attraction between the plunger holder and the suction unit is determined by the magnetic force between the plunger holder and the suction unit and the magnetic force between the plunger holder and the support unit. Is preferred.

  According to this aspect, the attraction force between the plunger holding portion and the suction portion can be determined by the magnetic force between the plunger holding portion and the suction portion, and the magnetic force between the plunger holding portion and the support portion, which is a force opposing the magnetic force. . By increasing the magnetic force between the plunger holding portion and the support portion, it is possible to prevent the plunger holding portion and the suction portion from coming into contact with each other due to the magnetic force, and the inner cylinder can be housed in the outer cylinder. .

  In order to achieve the above object, a microneedle array puncturing device according to the present invention includes an outer cylinder having an outer cylinder opening at one end and a first through hole on the side opposite to the outer cylinder opening, and an outer cylinder. The inner cylinder opening in the same direction as the outer cylinder opening, the plunger holding section on the side opposite to the inner cylinder opening, and the plunger holding section having a second through hole. A suction unit that sucks the microneedle array; and a support unit that supports the suction unit. The support unit moves the first through hole and the second through hole so that the suction unit moves inside. A plunger that is movable in the cylinder and a spring that is wound around the support portion and that is provided between the outer cylinder and the suction portion, and one of the plunger and the plunger holding portion is a magnet, The other is a magnetic material, and the firing force of the spring exerts microneed on the suction part. Array becomes stronger microneedle array lancing device than the force to adsorb.

  According to the microneedle array puncturing device of the present invention, by setting the firing force of the spring to be greater than the force at which the suction unit suctions the microneedle array, the biasing force of the spring removes the microneedle array from the suction unit. Can be. Therefore, the microneedle array can be removed from the microneedle array puncturing device without touching the microneedle array with a hand.

  In one aspect of the microneedle array puncturing device according to the present invention, the firing force of the spring is such that when the plunger holding section and the suction section are brought into contact with each other by magnetic force, the inner cylinder is stored in the outer cylinder. The biasing force of the spring when the holding unit and the suction unit are separated is preferable.

  According to this aspect, by moving the inner cylinder into the outer cylinder from a state in which the plunger holding portion and the suction portion are in contact with each other, a force is applied in a direction opposite to the biasing force of the spring. At the point where the biasing force of the spring is larger than the magnetic force of the plunger holding portion and the suction portion, the plunger holding portion and the suction portion are separated, and the biasing force of the spring at this time is used as the firing force of the spring. The microneedle array can be removed from the suction section.

  One mode of the microneedle array puncturing device according to the present invention is such that, in a state where the inner cylinder is housed in the outer cylinder, a force for pulling the plunger holding portion and the suction portion, and a biasing force for the spring to bias the suction portion. , It is preferable that the urging force is large.

  According to this aspect, it is possible to prevent the plunger holding portion and the suction portion from attracting and coming into contact with each other when the inner cylinder is housed in the outer cylinder. Therefore, when piercing the microneedle array into the puncture target, the inner cylinder can be punctured without applying a force opposing the magnetic force between the plunger holding portion and the suction portion, so that no extra force is applied. Puncture can be performed.

  In one aspect of the device for puncturing a microneedle array according to the present invention, it is preferable that the outer cylinder includes a holding portion fixed to the puncture target by being brought into contact with the puncture target around the outer cylinder opening.

  According to this aspect, the outer cylinder can be fixed to the puncture target by providing the holder around the outer cylinder opening of the outer cylinder and bringing the holder into contact with and pressing against the puncture target. Therefore, the microneedle array can be punctured vertically toward the puncture target, so that the needle-shaped convex portion of the microneedle array can be reliably punctured.

  In one aspect of the device for puncturing a microneedle array according to the present invention, the holding section preferably has an adhesive.

  According to this aspect, by applying the adhesive to the holding portion, the microneedle array puncturing device can be prevented from moving, and the needle-like convex portion of the microneedle array can be reliably punctured.

  In order to achieve the above object, the microneedle array puncturing set according to the present invention is a device for puncturing the microneedle array described above, a microneedle array, and a disposal container having an opening wider than the area of the suction section. , Is provided.

  According to the microneedle array puncturing set of the present invention, the microneedle array puncturing device can be reliably punctured by using the microneedle array puncturing device described above in combination with the microneedle array. In addition, by using a set of a disposal container having an opening larger than the area of the adsorption section, the used microneedle array can be surely disposed of.

  In one mode of the microneedle array puncturing set according to the present invention, it is preferable that the microneedle array has a magnetic material in the sheet portion or a magnetic material sheet in the sheet portion.

  According to this aspect, by having a magnetic material on the sheet portion of the microneedle array, or by having a magnetic material sheet, the microneedle array can be magnetically attracted to the attracting portion of the microneedle array puncturing device.

  In one aspect of the set for puncturing a microneedle array according to the present invention, it is preferable that the microneedle array is sealed in a container that is open on the side opposite to the surface on which the needle-shaped convex portions are formed.

  According to this aspect, the microneedle array is sealed in the container whose side opposite to the surface on which the needle-shaped convex portion is formed is opened, so that the microneedle array is directly adsorbed from the container to the microneedle array puncturing device. Can be done. Therefore, since the microneedle array is not touched by hands, contamination or breakage of the needle-shaped protrusion can be prevented.

  According to the microneedle array puncturing device and the microneedle array puncturing set of the present invention, contamination or breakage of the needle-shaped convex portion of the microneedle array can be prevented, and by pressing the outer cylinder, the microneedle array puncture can be prevented. Since the needle can be punctured, the microneedle can be punctured with a constant force. Furthermore, since the used microneedle array can be removed by the urging force of the spring, the microneedle array can be discarded without touching the hand. Therefore, a series of processes of taking out, puncturing, holding, and discarding the microneedle array can be performed without touching the needle-shaped convex portions. Thereby, it is possible to reduce both the risk of contamination and breakage of the needle-shaped convex portion of the microneedle array before puncturing and the risk of contact with body fluid attached to the microneedle array after puncturing.

It is sectional drawing which shows the state which the inner cylinder of the device for microneedle array puncture has protruded from the outer cylinder. FIG. 2 is a perspective view of the microneedle array puncturing device shown in FIG. 1. It is sectional drawing of a microneedle array. It is a figure which shows the process which adsorbs a microneedle array with an adsorption | suction part, and punctures a puncture target object. It is a figure which shows the process which adsorbs a microneedle array with an adsorption | suction part, and punctures a puncture target object. It is a figure which shows the process which adsorbs a microneedle array with an adsorption | suction part, and punctures a puncture target object. It is a figure which shows the process which adsorbs a microneedle array with an adsorption | suction part, and punctures a puncture target object. It is a figure which shows the process which adsorbs a microneedle array with an adsorption | suction part, and punctures a puncture target object. It is a figure showing a process of discarding a microneedle array. It is a figure showing a process of discarding a microneedle array. It is a figure showing a process of discarding a microneedle array.

  Hereinafter, a device for puncturing a microneedle array and a set for puncturing a microneedle array according to the present invention will be described with reference to the accompanying drawings. In addition, in this specification, "~" is used in the meaning including the numerical value described before and after it as a lower limit and an upper limit.

<Microneedle array puncturing device>
1 and 2 are views of a device for puncturing a microneedle array according to the present embodiment. FIG. 1 is a cross-sectional view showing a state in which an inner cylinder projects from an outer cylinder. FIG. 2 is a perspective view of FIG.

  The microneedle array puncturing device 10 of the present embodiment includes an outer tube 12, an inner tube 14, a plunger 16, and a spring 18. Hereinafter, each configuration will be described.

  The outer cylinder 12 has an outer cylinder opening 20 at one end, and is a cylinder that houses the inner cylinder 14 and the plunger 16. As for the size of the outer cylinder 12, it is preferable that the inner diameter is larger than the diameter of the microneedle array, and specifically, it is preferable that the inner diameter be 10 mm or more and 40 mm or less. In addition, since the outer cylinder 12 accommodates the inner cylinder 14, the inner diameter of the outer cylinder 12 is preferably larger than the outer shape of the inner cylinder 14. The height of the outer cylinder 12 depends on the puncture energy when puncturing the microneedle, and by making it shorter than the natural length of the spring 18, the microneedle array adsorbed on the plunger 16 by the biasing force of the spring 18 is punctured. Can be punctured. Specifically, it is preferable that the thickness be 10 mm or more and 200 mm or less.

  The outer cylinder 12 preferably includes a holding portion 22 around the outer cylinder opening 20. When the microneedle array is punctured, by pressing and fixing the holding portion 22 to the puncture target, the puncture target can be punctured without shifting the position of the microneedle array. As shown in FIG. 2, the holding portions 22 may be provided only at opposite ends of the outer cylinder opening 20. Further, the outer cylindrical opening 20 may be provided in a disk shape so as to surround the periphery thereof.

  Also, an adhesive may be applied to the outer cylinder opening 20 side of the holding unit 22, that is, the side that comes into contact with the puncture target. By applying the adhesive, when the device for puncturing the microneedle array is pressed, the device for puncturing the microneedle array is prevented from moving, and the microneedle array can be inserted vertically. As the adhesive, a medical double-sided tape or the like can be used. In addition, the movement of the microneedle array at the time of pressing may be prevented by fixing the holding unit 22 to the puncture target using a tape, a band, or the like.

  The material of the outer cylinder 12 is not particularly limited. As long as it has strength, for example, a resin, a metal, or the like can be used.

  The inner cylinder 14 includes an inner cylinder opening 24 and a plunger holder 26 on the side opposite to the inner cylinder opening 24, and can be stored in the outer cylinder 12. The inner cylinder opening 24 is formed so as to be in the same direction as the outer cylinder opening 20 during storage. A suction part 28 of the plunger 16 is arranged in the inner cylinder 14, and the microneedle array is suctioned to the suction part 28 from the inner cylinder opening 24. Therefore, the inner cylinder opening 24 preferably has an inner diameter larger than the diameter of the microneedle array. Further, since the plunger 16 moves in the inner cylinder 14, the inner diameter of the inner cylinder 14 is preferably larger than the diameter of the suction portion 28 of the plunger 16. Specifically, it is preferable that the inner diameter of the inner cylinder 14 be 8 mm or more and 38 mm or less.

  The height of the inner cylinder 14 is preferably the same as or lower than that of the outer cylinder 12 so that the inner cylinder 14 can be housed in the outer cylinder 12. If the height of the inner cylinder 14 is high, the device cannot be completely housed in the outer cylinder 12, and when piercing the microneedle array, the microneedle array puncturing device 10 is fixed at the tip of the inner cylinder 14. And it is not preferable because it becomes unstable. It is preferable that the height of the inner cylinder 14 be 10 mm or more and 200 mm or less.

  One of the plunger holding portion 26 and the plunger 16 is a magnet, and the other is a magnetic material, so that the plunger holding portion 26, that is, the inner cylinder 14 and the plunger 16 can be attracted by magnetic force.

  The material of the inner cylinder 14 is not particularly limited, as long as it has the same strength as the outer cylinder 12, and for example, a resin, a metal, or the like can be used. The material of the inner cylinder 14 is preferably the same as the material of the outer cylinder 12.

  The plunger 16 has a suction unit 28 that suctions the microneedle array, and a support unit 30 that supports the suction unit 28. The length of the plunger 16 is designed such that the total length of the length of the plunger 16 and the thickness of the sheet portion of the microneedle array is longer than the height of the outer cylinder 12. By making the sum of the length of the plunger 16 and the thickness of the seat portion longer than the height of the outer cylinder 12, the microneedle array can be ejected from the outer cylinder opening 20 by the urging force of the spring 18, and the microneedle array can be formed. The puncture target can be punctured.

  It is preferable that the size of the suction unit 28 be wider than the area of the microneedle array where the needle-shaped protrusions are formed. By adsorbing at least the back surface of the region of the microneedle array where the needle-shaped protrusions are formed by the suction unit, the needle-shaped protrusions of the microneedle array can be reliably punctured into the puncture target. Further, it is preferable that the diameter of the adsorption section is larger than the diameter of the microneedle array. By increasing the diameter of the suction section, the entire surface of the microneedle array can be suctioned, and the needle-like projection can be stably punctured.

  As a method of adsorbing the microneedle array to the adsorption section 28, for example, when the microneedle array has a magnetic substance, or when a magnetic sheet is attached, the microneedle array The array can be adsorbed by the adsorption unit 28. In addition, the microneedle array can be adsorbed by static electricity, and the microneedle array may be adsorbed by sucking from the adsorption section.

  The outer cylinder 12 and the plunger holding part 26 of the inner cylinder 14 have a first through hole 50 and a second through hole 52 through which the support part 30 of the plunger 16 moves. By moving the first through hole 50 and the second through hole 52 by the support portion 30, the plunger 16 can be movable in the inner cylinder 14.

  The spring 18 is wound around the support portion 30 of the plunger 16 and applies an urging force between the outer cylinder 12 and the attraction portion 28 of the plunger 16 to urge the attraction portion 28 in the direction of the outer cylinder opening 20. . When the outer cylinder 12 is pressed against the puncture target, the urging force urges the suction unit 28, and the suction unit 28 is pushed out, so that the microneedle array can be punctured. Adjustment of the load for pressing the microneedle array against the puncture target is performed by the length of the spring 18 and the spring constant. The load of the spring can be determined by Hooke's law, and can be determined by the product of the spring constant and the distance shortened from the natural length of the spring. It is preferable that the spring constant is not less than 0.1 N / mm and not more than 30 N / mm.

  The biasing force of the spring 18 is larger than the force of the plunger holding part 26 and the suction part 28 attracting when the inner cylinder 14 is housed in the outer cylinder 12. Thereby, the plunger holding portion 26 and the suction portion 28 are attracted from the state where the inner cylinder 14 is housed in the outer cylinder 12, and it is possible to prevent the inner cylinder 14 from jumping out of the outer cylinder 12 naturally. The attraction between the plunger holder 26 and the suction unit 28 is determined by the magnetic force between the plunger holder 26 and the suction unit 28 and the magnetic force between the plunger holder 26 and the support unit 30. When the distance between the plunger holding section 26 and the suction section 28 increases, the magnetic force between the plunger holding section 26 and the suction section 28 decreases, and the attractive force decreases.

  Further, the firing force of the spring 18 is given by the urging force of the spring 18. By making the firing force of the spring 18 stronger than the suction force between the suction unit 28 and the microneedle array, the microneedle array can be detached by the urging force of the spring 18.

<Microneedle array>
FIG. 3 is a sectional view of the microneedle array. The microneedle array of the present embodiment is not particularly limited as long as it is a size that can be attached to the microneedle array puncturing device. As the microneedle array, for example, the following sizes can be used.

  It is preferable that the diameter of the sheet portion 34 of the microneedle array be 10 mm or more and 30 mm or less. In addition, it is preferable that the region of the microneedle array where the needle-shaped protrusions 36 are formed has a size that fits into the suction portion 28 of the plunger 16. By making the region where the needle-shaped protrusions 36 are formed narrower than the region of the suction unit 28, the needle-shaped protrusions 36 can be pressed against the puncture target by the suction unit 28. If the area where the needle-shaped protrusion 36 is formed is wider than the suction part 28, the needle-shaped protrusion 36 that is not pressed by the suction part 28 is present. Is difficult to administer.

  It is preferable that the thickness of the sheet portion 34 of the microneedle array 32 be 0.1 mm or more and 5 mm or less. Further, it is preferable that the number of the needle-like convex portions 36 is 4 or more and 1000 or less, and the length of the needle-like convex portions 36 is preferably 0.2 mm or more and 1.5 mm or less.

  The microneedle array 32 preferably includes a magnetic material in order to cause the microneedle array 32 to be adsorbed by the adsorption unit 28. By including the magnetic material, when the plunger 16 is formed of a magnet, it can be attracted by magnetic force. As a method of causing the microneedle array to contain a magnetic material, as shown in FIG. 3, a magnetic material sheet can be attached to the back side of the microneedle array (the side opposite to the surface on which the needle-shaped protrusions are formed). . Further, at the time of manufacturing the microneedle array, a magnetic material may be contained in the sheet portion. When the microneedle array does not contain a magnetic substance, the microneedle array and the suction unit may be adsorbed by static electricity or by suction from the suction unit of the microneedle array puncturing device.

  It is preferable to use a biocompatible resin as a material for forming the microneedle array. Examples of such resins include sugars such as glucose, maltose, pullulan, sodium chondroitin sulfate, sodium hyaluronate, and hydroxyethyl starch, proteins such as gelatin, and biodegradable polymers such as polylactic acid and lactic acid / glycolic acid copolymer. Can be used.

  The drug contained in the microneedle array is not limited as long as it has a function as a drug. In particular, it is preferable to select a drug selected from peptides, proteins, nucleic acids, polysaccharides, vaccines, pharmaceutical compounds belonging to water-soluble low molecular weight compounds, or cosmetic components.

  The shape of the needle-shaped convex portion of the microneedle array is not particularly limited as long as the tip is tapered. For example, the shape can be a cone or a pyramid such as a triangular pyramid or a quadrangular pyramid. Further, it can be formed by a tapered needle portion and a frustum portion connected to the needle portion.

<Operation of microneedle array puncturing device>
Next, the operation of the microneedle array puncturing device will be described with reference to FIGS. 4 to 8 are diagrams illustrating a process of sucking the microneedle array by the suction unit and puncturing the puncture target. 9 to 11 are views showing a process of discarding the used microneedle array.

  First, as shown in FIG. 4, a microneedle array 32 is prepared. The microneedle array 32 is housed in a container 40 in which the needle-shaped convex portions 36 face downward, and the upward direction is disposed as the back surface side of the sheet portion 34. Can be adsorbed on the adsorption section 28 of the microneedle array puncturing device 10 by releasing the. Thereby, the needle-shaped convex portion 36 can be adsorbed to the microneedle array puncturing device 10 without contamination and breakage.

  5 and 6 are diagrams in which the microneedle array 32 is adsorbed by the microneedle array puncturing device 10. FIG. As shown in FIG. 5, the inner cylinder 14 is taken out of the outer cylinder 12, and the plunger holding section 26 and the adsorption section 28 of the plunger 16 are attracted by magnetic force. In this state, the tip of the inner cylinder 14 is brought into contact with the container 40 in which the microneedle array 32 is stored. By bringing the microneedle array puncturing device 10 into contact with the container 40, the microneedle array 32 in the container 40 can be adsorbed to the adsorbing section 28 (FIG. 6). Since the periphery of the microneedle array 32 is covered by the inner cylinder 14, the inner cylinder 14 serves as a guide, and the microneedle array 32 can be surely sucked on the back surface of the microneedle array 32.

  When the microneedle array puncturing device 10 is arranged and the microneedle array 32 is not sucked, the outer cylinder 12 is pressed to bring the suction unit 28 into contact with the microneedle array 32 and to be sucked by the suction unit 28. be able to. At this time, the plunger holding section 26 and the suction section 28 are separated, and the inner cylinder 14 is housed in the outer cylinder 12. When the inner cylinder 14 is housed in the outer cylinder 12, since the suction part 28 and the plunger holding part 26 have a distance, the plunger holding part 26 and the support part 30 attract by magnetic force, and the plunger holding part 26 is Do not contact with Therefore, the inner cylinder 14 maintains the state housed in the outer cylinder 12.

  FIG. 7 is a diagram illustrating a state where the microneedle array puncturing device 10 is pressed against the puncture target (skin) 44, and FIG. 8 is a diagram illustrating a state where the microneedle array is punctured into the skin. FIG. 7 illustrates a case where the microneedle array 32 is punctured from a state in which the inner cylinder 14 is protruding from the outer cylinder 12.

  By bringing the tip of the inner cylinder 14 into contact with the skin and pressing the outer cylinder 12, the suction portion 28 of the plunger 16 is urged toward the outer cylinder opening 20 by the spring 18, and is attracted by the suction portion 28. Needle array 32 is punctured into skin 44. By pressing the outer cylinder 12, the inner cylinder 14 is housed in the outer cylinder 12. At this time, when the urging force of the spring 18 for urging the suction unit 28 becomes stronger than the magnetic force between the suction unit 28 and the plunger holding unit 26, the plunger holding unit 26 and the suction unit 28 are separated, and the suction unit 28 When energized, the microneedle array 32 is punctured into the skin 44 as shown in FIG. In a state where the microneedle array 32 is punctured as shown in FIG. 8, when the inner cylinder 14 is housed in the outer cylinder 12, the plunger is held similarly to the case where the microneedle array 32 is sucked by the suction unit 28. The part 26 and the support part 30 are attracted by magnetic force and do not come into contact with each other. Therefore, after the outer cylinder 12 is pressed and the inner cylinder 14 is stored in the outer cylinder 12, the inner cylinder 14 does not come out of the outer cylinder 12. 32 can be punctured.

  When the microneedle array 32 is punctured, the holding unit 22 provided on the outer cylinder 12 is brought into contact with the skin, so that the microneedle array puncturing device 10 can be prevented from moving, and can be stably performed. The microneedle array 32 can be punctured into the skin.

  9 to 11 are views showing a process of discarding the microneedle array after puncturing (after use).

  As shown in FIG. 9, after puncturing the microneedle array 32, the microneedle array puncturing device 10 is separated from the skin 44. The microneedle array puncturing device 10 maintains the state where the inner tube 14 is housed in the outer tube 12. In addition, the needle-like convex portion 36 of the microneedle array remains in the skin 44 by puncturing the microneedle array 32, and the medicine contained in the needle-like convex portion 36 can be administered into the skin.

  When the used microneedle array 32 is discarded, the inner cylinder 14 housed in the outer cylinder 12 is pulled out by hand, for example, by pulling the inner cylinder 14 out of the outer cylinder 12 by slightly applying a force. . By applying a force to the inner cylinder 14, the distance between the plunger holding part 26 and the suction part 28 is shortened, and the plunger holding part 26 and the suction part 28 are attracted by the magnetic force, so that the inner cylinder 14 jumps out of the outer cylinder 12. be able to.

  In this state, as shown in FIG. 10, a disposal container 46 having an opening 48 is prepared, and the tip of the inner cylinder 14 is brought into contact with the periphery of the opening 48. In this state, the outer cylinder 12 is pressed. As the outer cylinder 12 is pressed, the spring 18 contracts, and the urging force of the spring 18 urging the suction portion 28 increases. When the urging force becomes larger than the magnetic force between the plunger holding part 26 and the suction part 28, the plunger holding part 26 and the suction part 28 are detached. When the plunger holding part 26 and the suction part 28 are detached, the suction part 28 moves toward the outer cylinder opening 20 by the urging force of the spring 18. The biasing force at this time is the firing force of the spring 18.

  By comparing the firing force of the spring 18 with the force of the suction unit 28 sucking the microneedle array 32 and increasing the firing force of the spring 18, as shown in FIG. 28 and is disposed of in a disposal container 46. The microneedle array 32 is discarded directly from the microneedle array puncturing device 10. Thus, the used microneedle array 32 can be discarded without touching the hand. The opening 48 is preferably larger than the area of the suction unit 28. By making the area larger than the area of the suction section 28, the microneedle array can be surely discarded from the opening 48 to the discarding container 46.

<Microneedle array puncture set>
The microneedle array puncturing set is preferably used in combination with a microneedle array and a disposal container.

  The microneedle array has a magnetic material in the sheet portion, or a magnetic material sheet is attached to the sheet portion, so that the microneedle array can be easily adsorbed to the adsorption portion of the device for puncturing the microneedle array.

  The disposal container has an opening for discarding the microneedle array. By making the opening wider than the adsorbing section, the microneedle array adsorbed on the adsorbing section can be discarded in the disposal container.

  Further, in the container for enclosing the microneedle array, the needle-shaped convex portion of the microneedle array faces downward, and the side opposite to the needle-shaped convex portion is opened, so that the microneedle array can be adsorbed by the adsorbing portion. At this time, a frame is provided so that the needle-shaped protrusion does not hit the bottom surface of the container, and a sheet portion is provided on the frame, whereby the needle-shaped protrusion can be prevented from being bent.

  By using these microneedle array puncturing sets, the microneedle array can be set without touching the microneedle array puncturing device, and the microneedle array can be pressed with a constant force. Furthermore, the microneedle array can be discarded without touching. Therefore, it is possible to reduce both the risk of contamination and breakage of the needle-shaped convex portion before puncturing and the risk of contact of bodily fluids attached to the microneedle array after puncturing.

DESCRIPTION OF SYMBOLS 10 Microneedle array puncturing device 12 Outer cylinder 14 Inner cylinder 16 Plunger 18 Spring 20 Outer cylinder opening 22 Retaining part 24 Inner cylinder opening 26 Plunger holding part 28 Suction part 30 Support part 32 Microneedle array 34 Sheet part 36 Needle shape Convex portion 38 Magnetic sheet 40 Container 42 Cover 44 Puncture target (skin)
46 disposal container 48 opening 50 first through hole 52 second through hole

Claims (9)

An outer cylinder having an outer cylinder opening at one end and a first through hole on the opposite side of the outer cylinder opening;
The inner cylinder opening can be stored in the outer cylinder, and at the time of storage, the inner cylinder opening has a plunger holding portion in the same direction as the outer cylinder opening, and a plunger holding portion opposite to the inner cylinder opening has a second plunger holding portion. An inner cylinder having a through hole of
A suction unit that sucks the microneedle array; and a support unit that supports the suction unit. The support unit moves the first through-hole and the second through-hole to form the suction unit. A plunger that is movable in the inner cylinder,
A spring that is wound around the support portion and is provided between the outer cylinder and the suction portion, and biases the suction portion toward the outer cylinder opening.
One of the plunger and the plunger holding portion is a magnet, the other is a magnetic material,
In a state where the inner cylinder is housed in the outer cylinder, when the force for pulling the plunger holding portion and the suction portion is compared with the biasing force for biasing the suction portion by the spring, the biasing force is determined. Device for microneedle array puncture.   2. The microneedle according to claim 1, wherein the attraction between the plunger holding unit and the suction unit is determined by a magnetic force between the plunger holding unit and the suction unit and a magnetic force between the plunger holding unit and the support unit. 3. Array puncture device. An outer cylinder having an outer cylinder opening at one end and a first through hole on the opposite side of the outer cylinder opening;
The inner cylinder opening can be stored in the outer cylinder, and at the time of storage, the inner cylinder opening has a plunger holding portion in the same direction as the outer cylinder opening, and a plunger holding portion opposite to the inner cylinder opening has a second plunger holding portion. An inner cylinder having a through hole of
A suction unit that sucks the microneedle array; and a support unit that supports the suction unit. The support unit moves the first through-hole and the second through-hole, so that the suction unit A plunger that is movable in the inner cylinder;
Comprising a spring wound around the support portion and provided between the outer cylinder and the suction portion,
One of the plunger and the plunger holding portion is a magnet, the other is a magnetic material,
Firing force of the spring, the strongly than the force for adsorbing the microneedle array to the adsorption unit,
The firing force of the spring is such that the plunger holder and the suction unit are separated when the inner cylinder is housed in the outer cylinder from a state in which the plunger holder and the suction unit are in contact with each other by magnetic force. A microneedle array puncturing device, which is a biasing force of the spring at the time . In a state where the inner cylinder is housed in the outer cylinder, when the force for pulling the plunger holding portion and the suction portion is compared with the biasing force for biasing the suction portion by the spring, the biasing force is determined. The device for puncturing a microneedle array according to claim 3 , wherein The microneedle array according to any one of claims 1 to 4 , wherein the outer cylinder includes a holding portion that is fixed to the puncture target by being brought into contact with the puncture target around the outer cylinder opening. Puncture device. The device for puncturing a microneedle array according to claim 5 , wherein the holding unit has an adhesive. A device for puncturing a microneedle array according to any one of claims 1 to 6 ,
A microneedle array,
And a disposal container having an opening larger than the area of the suction unit. The microneedle array puncturing set according to claim 7 , wherein the microneedle array has a magnetic material in a sheet portion or a magnetic material sheet in a sheet portion. The microneedle array is needle-like protrusions microneedle array puncture set according to claim 7 or 8 and formed a surface opposite is sealed in a container to be opened.

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