JP6626498B2 - 血流特性及び病理を心筋血液供給のモデリングを介して決定するためのシステム及び方法 - Google Patents

血流特性及び病理を心筋血液供給のモデリングを介して決定するためのシステム及び方法 Download PDF

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JP6626498B2
JP6626498B2 JP2017511193A JP2017511193A JP6626498B2 JP 6626498 B2 JP6626498 B2 JP 6626498B2 JP 2017511193 A JP2017511193 A JP 2017511193A JP 2017511193 A JP2017511193 A JP 2017511193A JP 6626498 B2 JP6626498 B2 JP 6626498B2
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レオ ジェイ． グラディー，
レオ ジェイ． グラディー，
チャールズ エー． テイラー，
チャールズ エー． テイラー，
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ハートフロー， インコーポレイテッド
ハートフロー， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0044—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T19/00—Manipulating 3D models or images for computer graphics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
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    • G—PHYSICS
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    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/023—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0263—Measuring blood flow using NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0883—Clinical applications for diagnosis of the heart
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2210/00—Indexing scheme for image generation or computer graphics
    • G06T2210/41—Medical
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Data Mining & Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Computer Graphics (AREA)
  • Computer Hardware Design (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Evolutionary Biology (AREA)
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  • Signal Processing (AREA)
  • Psychiatry (AREA)
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JP2017511193A 2014-08-29 2015-08-19 血流特性及び病理を心筋血液供給のモデリングを介して決定するためのシステム及び方法 Active JP6626498B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462043699P 2014-08-29 2014-08-29
US62/043,699 2014-08-29
US14/529,495 2014-10-31
US14/529,495 US9386933B2 (en) 2014-08-29 2014-10-31 Systems and methods for determination of blood flow characteristics and pathologies through modeling of myocardial blood supply
PCT/US2015/045889 WO2016032819A1 (en) 2014-08-29 2015-08-19 Systems and methods for determination of blood flow characteristics and pathologies through modeling of myocardial blood supply

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JP2019216290A Division JP7039544B2 (ja) 2014-08-29 2019-11-29 血流特性及び病理を心筋血液供給のモデリングを介して決定するためのシステム及び方法

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JP2017525497A JP2017525497A (ja) 2017-09-07
JP2017525497A5 JP2017525497A5 (OSRAM) 2018-07-19
JP6626498B2 true JP6626498B2 (ja) 2019-12-25

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JP2019216290A Active JP7039544B2 (ja) 2014-08-29 2019-11-29 血流特性及び病理を心筋血液供給のモデリングを介して決定するためのシステム及び方法

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US (5) US9386933B2 (OSRAM)
EP (1) EP3185762B1 (OSRAM)
JP (2) JP6626498B2 (OSRAM)
WO (1) WO2016032819A1 (OSRAM)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10210956B2 (en) 2012-10-24 2019-02-19 Cathworks Ltd. Diagnostically useful results in real time
WO2014182505A1 (en) 2013-05-10 2014-11-13 Stenomics, Inc. Modeling and simulation system for optimizing prosthetic heart valve treatment
US9092743B2 (en) 2013-10-23 2015-07-28 Stenomics, Inc. Machine learning system for assessing heart valves and surrounding cardiovascular tracts
US9386933B2 (en) 2014-08-29 2016-07-12 Heartflow, Inc. Systems and methods for determination of blood flow characteristics and pathologies through modeling of myocardial blood supply
US12008751B2 (en) 2015-08-14 2024-06-11 Elucid Bioimaging Inc. Quantitative imaging for detecting histopathologically defined plaque fissure non-invasively
US10176408B2 (en) 2015-08-14 2019-01-08 Elucid Bioimaging Inc. Systems and methods for analyzing pathologies utilizing quantitative imaging
US12026868B2 (en) 2015-08-14 2024-07-02 Elucid Bioimaging Inc. Quantitative imaging for detecting histopathologically defined plaque erosion non-invasively
US11087459B2 (en) 2015-08-14 2021-08-10 Elucid Bioimaging Inc. Quantitative imaging for fractional flow reserve (FFR)
US11676359B2 (en) 2015-08-14 2023-06-13 Elucid Bioimaging Inc. Non-invasive quantitative imaging biomarkers of atherosclerotic plaque biology
US11113812B2 (en) 2015-08-14 2021-09-07 Elucid Bioimaging Inc. Quantitative imaging for detecting vulnerable plaque
US11071501B2 (en) 2015-08-14 2021-07-27 Elucid Bioiwaging Inc. Quantitative imaging for determining time to adverse event (TTE)
US11094058B2 (en) 2015-08-14 2021-08-17 Elucid Bioimaging Inc. Systems and method for computer-aided phenotyping (CAP) using radiologic images
EP4241694A3 (en) 2016-05-16 2023-12-20 Cathworks Ltd. Selection of vascular paths from images
KR102744520B1 (ko) 2017-10-06 2024-12-20 에모리 유니버시티 하나 이상의 동맥 세그먼트에 대한 혈역학 정보를 결정하기 위한 방법 및 시스템
US11871995B2 (en) 2017-12-18 2024-01-16 Hemolens Diagnostics Sp. Z O.O. Patient-specific modeling of hemodynamic parameters in coronary arteries
EP3899864B1 (en) 2019-08-05 2025-11-05 Elucid Bioimaging Inc. Combined assessment of morphological and perivascular disease markers
US11969280B2 (en) 2020-01-07 2024-04-30 Cleerly, Inc. Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
US20220392065A1 (en) 2020-01-07 2022-12-08 Cleerly, Inc. Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
WO2021141921A1 (en) 2020-01-07 2021-07-15 Cleerly, Inc. Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking
US11636603B2 (en) * 2020-11-03 2023-04-25 Dyad Medical, Inc. System and methods for segmentation and assembly of cardiac MRI images
CN113520363B (zh) * 2021-06-25 2023-08-25 安影科技（北京）有限公司 一种下丘脑及垂体的血流灌注获取方法及系统
CN113506640B (zh) * 2021-08-17 2022-05-31 首都医科大学附属北京友谊医院 脑灌注状态分类装置、方法、设备及模型训练装置
US12315076B1 (en) 2021-09-22 2025-05-27 Cathworks Ltd. Four-dimensional motion analysis of a patient's coronary arteries and myocardial wall
CN118985005A (zh) 2022-02-10 2024-11-19 凯思沃克斯有限公司 用于基于机器学习的传感器分析和血管树分割的系统和方法
US12406365B2 (en) 2022-03-10 2025-09-02 Cleerly, Inc. Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
US20250217981A1 (en) 2022-03-10 2025-07-03 Cleerly, Inc. Systems, methods, and devices for image-based plaque analysis and risk determination
US12440180B2 (en) 2022-03-10 2025-10-14 Cleerly, Inc. Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
US20250143657A1 (en) 2022-03-10 2025-05-08 Cleerly, Inc. Systems, devices, and methods for non-invasive image-based plaque analysis and risk determination
US12446965B2 (en) 2023-08-09 2025-10-21 Cathworks Ltd. Enhanced user interface and crosstalk analysis for vascular index measurement

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8527251B2 (en) * 2009-05-01 2013-09-03 Siemens Aktiengesellschaft Method and system for multi-component heart and aorta modeling for decision support in cardiac disease
US8315812B2 (en) * 2010-08-12 2012-11-20 Heartflow, Inc. Method and system for patient-specific modeling of blood flow
US9119540B2 (en) * 2010-09-16 2015-09-01 Siemens Aktiengesellschaft Method and system for non-invasive assessment of coronary artery disease
US8548778B1 (en) 2012-05-14 2013-10-01 Heartflow, Inc. Method and system for providing information from a patient-specific model of blood flow
US9675301B2 (en) * 2012-10-19 2017-06-13 Heartflow, Inc. Systems and methods for numerically evaluating vasculature
BR112015013248A2 (pt) * 2012-12-11 2017-07-11 Koninklijke Philips Nv método de determinação do fluxo sanguíneo através das artérias coronárias, processador (36) para determinar o fluxo sanguíneo através das artérias coronárias, dispositivo de imageamento e programa de computador
US10485517B2 (en) * 2013-02-15 2019-11-26 The Johns Hopkins University Computational flow dynamics based method for estimating thromboembolic risk in patients with myocardial infarction
US9805463B2 (en) * 2013-08-27 2017-10-31 Heartflow, Inc. Systems and methods for predicting location, onset, and/or change of coronary lesions
US9390232B2 (en) * 2014-03-24 2016-07-12 Heartflow, Inc. Systems and methods for modeling changes in patient-specific blood vessel geometry and boundary conditions
US9087147B1 (en) * 2014-03-31 2015-07-21 Heartflow, Inc. Systems and methods for determining blood flow characteristics using flow ratio
US9754082B2 (en) * 2014-05-30 2017-09-05 Heartflow, Inc. Systems and methods for reporting blood flow characteristics
US9386933B2 (en) * 2014-08-29 2016-07-12 Heartflow, Inc. Systems and methods for determination of blood flow characteristics and pathologies through modeling of myocardial blood supply

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Publication number Publication date
US10213119B2 (en) 2019-02-26
US20160058303A1 (en) 2016-03-03
JP7039544B2 (ja) 2022-03-22
US12178557B2 (en) 2024-12-31
JP2020044357A (ja) 2020-03-26
EP3185762A1 (en) 2017-07-05
US20160283689A1 (en) 2016-09-29
JP2017525497A (ja) 2017-09-07
US20190142281A1 (en) 2019-05-16
US20190133456A1 (en) 2019-05-09
US20250090034A1 (en) 2025-03-20
WO2016032819A1 (en) 2016-03-03
EP3185762B1 (en) 2024-07-03
US9386933B2 (en) 2016-07-12

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