JP6600426B1 - Antibacterial composition - Google Patents
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Abstract
【課題】土壌処理、付着防止が可能な抗菌性の組成物を使用可能な限られた公知の化合物等を用いて開発することが望まれている。【解決手段】2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール、2-メルカプトピリジン N-オキシドナトリウム、N-アセチル-N-ブチル-β-アラニンエチル、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリドを含有する抗菌組成物。【選択図】なしIt is desired to develop an antibacterial composition capable of soil treatment and adhesion prevention using a limited number of known compounds that can be used. SOLUTION: 2- (methoxycarbonylamino) -1H-benzimidazole, 2-mercaptopyridine N-oxide sodium, N-acetyl-N-butyl-β-alanine ethyl, and tetradecyl [3- (trimethoxysilyl) propyl ] An antibacterial composition containing dimethylaminium chloride. [Selection figure] None
Description
本発明は、特定の化合物を組み合わせた、優れた効能を有する抗菌組成物およびその利用に関する。 The present invention relates to an antibacterial composition having a combination of specific compounds and having excellent efficacy, and use thereof.
野菜などの栽培においては、土壌の管理が重要であり、野菜などの病害を引き起こす菌を特定しその菌に有効な抗菌剤で土壌を処理することが行われている。また、海などで用いる網とか船には、藻類、フジツボ、イガイ、紫ガイ、ヒドロ虫、イソギンチャクなどの付着防し、その使用を妨げるため、付着防止に効果的な方法が必要とされている。さらには、小便が流れる配管は尿石が成長してくるため、その除去に多くの労力が必要とされている。 In the cultivation of vegetables and the like, it is important to manage the soil, and a fungus that causes diseases such as vegetables is identified and the soil is treated with an antibacterial agent effective for the fungus. In addition, nets and ships used in the sea, etc., need to have an effective method for preventing adhesion to prevent and prevent the use of algae, barnacles, mussels, purple mussels, hydroworms, sea anemones, etc. . Furthermore, since the urine stone grows in the pipe through which the urine flows, much labor is required to remove it.
上記のような課題を解決することが可能な抗菌性の組成物を使用可能な限られた公知の化合物等を用いて開発することができれば、非常に好ましく、その開発が望まれている。 If it can develop using the limited well-known compound etc. which can use the antibacterial composition which can solve the above subjects, it will be very preferable and the development is desired.
本発明者らは上記問題を解決する方法を鋭意検討し、特定の化合物を組み合わせた組成物を用いることで上記問題が解決できることを見出し本発明を完成した。 The present inventors have intensively studied a method for solving the above problem, and found that the above problem can be solved by using a composition in which a specific compound is combined, thereby completing the present invention.
即ち、本発明は、2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール、2-メルカプトピリジン N-オキシドナトリウム、N-アセチル-N-ブチル-β-アラニンエチル、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリドを含有する抗菌組成物である。 That is, the present invention relates to 2- (methoxycarbonylamino) -1H-benzimidazole, 2-mercaptopyridine N-oxide sodium, N-acetyl-N-butyl-β-alanine ethyl, and tetradecyl [3- (trimethoxysilyl ) Propyl] dimethylaminium chloride.
本発明はまた、2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール、2-メルカプトピリジン N-オキシドナトリウム、N-アセチル-N-ブチル-β-アラニンエチル、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリドの各成分をそれぞれ、0.1〜99.7重量％含有する抗菌組成物である。 The present invention also includes 2- (methoxycarbonylamino) -1H-benzimidazole, 2-mercaptopyridine N-oxide sodium, N-acetyl-N-butyl-β-alanine ethyl, and tetradecyl [3- (trimethoxysilyl) Propyl] dimethylaminium chloride is an antibacterial composition containing 0.1 to 99.7% by weight of each component.
本発明はまた、上記抗菌組成物を真菌および／又は細菌による土壌伝染性病害の予防に用いる野菜の栽培方法である。 The present invention is also a vegetable cultivation method using the antibacterial composition for preventing soil-borne diseases caused by fungi and / or bacteria.
本発明はまた、上記の抗菌組成物を藻類、フジツボ、イガイ、紫ガイ、ヒドロ虫、又はイソギンチャクの付着防止剤に用いる付着防止方法である。 The present invention is also a adhesion preventing method using the above antimicrobial compositions algae, barnacles, mussels, mussels, hydroids, or adhesion inhibitor of Isogincha click.
本発明はまた、上記抗菌組成物とシリコン変性アクリル樹脂と銅粉およびシリコンオイルからなる付着防止塗料である。 The present invention is also an anti-adhesion paint comprising the antibacterial composition, a silicon-modified acrylic resin, copper powder, and silicon oil.
本発明はまた、上記抗菌組成物を小便器の排水管の内面に塗布する尿石の固着防止方法である。 The present invention is also a method for preventing adhesion of urine stone, wherein the antibacterial composition is applied to the inner surface of a drain pipe of a urinal.
本発明の組成物は、広い範囲の用途に活用可能で極めて効果の大きい抗菌組成物であり真菌、原核生物が起こす野菜などの青枯病、立ち枯病など種々病気を治すとか微生物による付着の防止など種々の用途に利用でき工業的に極めて価値のあるものである。 The composition of the present invention is an extremely effective antibacterial composition that can be used for a wide range of applications. It cures various diseases such as bacterial wilt and leaf blight caused by fungi, prokaryotic vegetables, etc. It can be used for various purposes such as prevention, and is extremely valuable industrially.
本発明において、2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール（CAS RN＝10605-21-7）、2-メルカプトピリジン N-オキシドナトリウム（CAS RN=3811-73-2）、N-アセチル-N-ブチル-β-アラニンエチル（CA RN=52304-36-6）、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリド（CA RN=41591-87-1）の4種の化合物は公知の化合物であり、市場で入手可能であり、本発明の用途に対して、格別の害を及ぼすような不純物を含まないものが好ましく利用できる。 In the present invention, 2- (methoxycarbonylamino) -1H-benzimidazole (CAS RN = 10605-21-7), 2-mercaptopyridine sodium N-oxide (CAS RN = 3811-73-2), N-acetyl- N-butyl-β-alanine ethyl (CA RN = 52304-36-6) and tetradecyl [3- (trimethoxysilyl) propyl] dimethylaminium chloride (CA RN = 41591-87-1) A compound is a well-known compound, and it can obtain in a market, The thing which does not contain the impurity which gives special harm to the use of this invention can be utilized preferably.
上記4種の化合部の使用割合としては、各成分が少なくとも０．１重量％、好ましくは1重量％以上、特に好ましくは5重量％以上であり、各成分を等しく２５重量％としても良い。 The use ratio of the above four kinds of compound parts is at least 0.1% by weight of each component, preferably at least 1% by weight, particularly preferably at least 5% by weight, and each component may be equally 25% by weight.
本発明の組成物は、野菜の栽培の際に、土壌と混合して用いるに際しては、組成物を水に溶解して散布してもよく、場合によっては、一部の土に分散して濃い濃度で混合した土を広く分散する方法であっても良く、土壌１００ｍ２に対して組成物が２ｇ〜３ｇ程度となるよう散布するのが好ましい。 When the composition of the present invention is mixed with soil during vegetable cultivation, the composition may be dissolved in water and sprayed. In some cases, the composition is dispersed and concentrated in some soil. A method of widely dispersing soil mixed at a concentration may be used, and it is preferable that the composition is sprayed to about 2 to 3 g with respect to 100 m 2 of soil.
海洋での用途に際し、付着防止に用いる場合には、塗料として用いる場合には、塗料１００ｇに対し、組成物を４ｇ〜７ｇとするのが一般的であり、漁網などに塗布するに際しては、定置網の重量比１８％の濃度でディピング方法にて塗布するのが一般的である。 In the case of use in the ocean, when used as a paint, when used as a paint, the composition is generally 4 g to 7 g with respect to 100 g of the paint. It is common to apply by a dipping method at a concentration of 18% by weight.
尿石の付着防止に用いるには、組成物を水に○ｇ/Ｌ程度に分散してスプレーで塗布するのが一般的であり、実際に用いるには、まず尿が流れる配管を洗剤とブラシ等で良く洗浄した後、上記溶液を塗布し乾燥？するのが良い。 In order to prevent adhesion of urinary stones, it is common to disperse the composition in water to a level of ○ g / L and apply it with a spray. After washing well with etc., apply the above solution and dry it? Good to do.
［実施例１］
2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール25部、2-メルカプトピリジン N-オキシドナトリウム25部、N-アセチル-N-ブチル-β-アラニンエチル25部、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリド25部からなる組成物を野菜を育てた後の土壌に1000ｐｐｍとなるように分散して、他の条件は従来と同様にしてキャベツの苗を植えで育成したところ萎黄病の発生は見られなかった。
［比較例１］
[Example 1]
2- (methoxycarbonylamino) -1H-benzimidazole 25 parts, 2-mercaptopyridine N-oxide sodium 25 parts, N-acetyl-N-butyl-β-alanine ethyl 25 parts, and tetradecyl [3- (trimethoxysilyl )] Propyl] dimethylaminium chloride 25 parts of the composition was dispersed in the soil after growing vegetables to 1000ppm, the other conditions were planted and grown cabbage seedlings as before No yellowing was observed.
[Comparative Example 1]
実施例１の処理を行わずに育成したところ１０００本/１０００本に萎黄病他の病状が発生した。また2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール25部を欠いた処方では１０００本、2-メルカプトピリジン N-オキシドナトリウム25部を欠いた処方では１０００本／１０００本、N-アセチル-N-ブチル-β-アラニンエチル25部を欠いた処方では１０００本/１０００本、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリド25部を欠いた処方では１０００本／１０００本の萎黄病他の病状の発生が見られた。
［実施例２］
When grown without carrying out the treatment of Example 1, 1000/1000 wilts and other medical conditions occurred. In addition, 1000 prescriptions lacking 25 parts 2- (methoxycarbonylamino) -1H-benzimidazole, 1000/1000 prescriptions lacking 25 parts 2-mercaptopyridine N-oxide sodium, N-acetyl-N- 1000/1000 with a prescription lacking 25 parts of butyl-β-alanine ethyl and 1000/1000 with a prescription lacking 25 parts of tetradecyl [3- (trimethoxysilyl) propyl] dimethylaminium chloride The occurrence of other medical conditions was observed.
[Example 2]
2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール25部、2-メルカプトピリジン N-オキシドナトリウム25部、N-アセチル-N-ブチル-β-アラニンエチル25部、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリド25部からなる組成物を水に分散して１０００ｐｐｍの液とし漁網に乾燥後の組成物が２００ｇ/ｍ２になるように塗布した。天日で乾燥した後、水深６ｍのところに保持した。６か月経過後に取り出して観察したところ、藻、フジツボなどの付着は見られなかった。
［比較例２］
2- (methoxycarbonylamino) -1H-benzimidazole 25 parts, 2-mercaptopyridine N-oxide sodium 25 parts, N-acetyl-N-butyl-β-alanine ethyl 25 parts, and tetradecyl [3- (trimethoxysilyl )] Propyl] dimethylaminium chloride 25 parts of a composition was dispersed in water to give a 1000 ppm solution and applied to a fishing net so that the dried composition was 200 g / m 2 . After drying in the sun, it was kept at a depth of 6 m. When taken out and observed after 6 months, no adhesion of algae, barnacles, etc. was observed.
[Comparative Example 2]
実施例２の処理を行わずに海水中に保持したところ網の面に８０％程度の部分に藻などが着いていた。また2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール25部を欠いた処方では９０％、2-メルカプトピリジン N-オキシドナトリウム25部を欠いた処方では１００％、N-アセチル-N-ブチル-β-アラニンエチル25部を欠いた処方では７５％、テトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリド25部を欠いた処方では７５％の面に藻などが付着した。
［実施例３］
When it was kept in seawater without carrying out the treatment of Example 2, algae or the like had adhered to about 80% of the net surface. Also, 90% for the formulation lacking 25 parts of 2- (methoxycarbonylamino) -1H-benzimidazole, 100% for the formulation lacking 25 parts of 2-mercaptopyridine N-oxide sodium, N-acetyl-N-butyl-β -Algae and the like adhered to 75% of the formulation lacking 25 parts of alanine ethyl and 75% of the formulation lacking 25 parts of tetradecyl [3- (trimethoxysilyl) propyl] dimethylaminium chloride.
[Example 3]
2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール25部、2-メルカプトピリジン N-オキシドナトリウム25部、N-アセチル-N-ブチル-β-アラニンエチル25部、およびテトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリド25部からなる組成物を水に分散して１０００ｐｐｍの液とし十分に洗浄した小便が流れるパイプの内表面に塗布し十分に乾燥した後、小便の排水側に組み込んだ。５か月使用した後、配管の内面を観察したところ図１に示すように、尿石の付着はほとんど観察されなかった。
［比較例３］
2- (methoxycarbonylamino) -1H-benzimidazole 25 parts, 2-mercaptopyridine N-oxide sodium 25 parts, N-acetyl-N-butyl-β-alanine ethyl 25 parts, and tetradecyl [3- (trimethoxysilyl )] Propyl] dimethylaminium chloride 25 parts dispersed in water to make a 1000ppm solution, thoroughly washed and applied to the inner surface of the pipe where the urine flows, and then dried and then incorporated into the urine drainage side It is. After 5 months of use, the inner surface of the pipe was observed, and as shown in FIG.
[Comparative Example 3]
実施例１３の組成物による処理を行わず洗浄と乾燥だけした後組み込んで実施例３と同様に使用したところ２か月で流れが不良になり内面を観察したところ、図２に示すように尿石の成長が見られた。また2-(メトキシカルボニルアミノ)-1H-ベンゾイミダゾール25部を欠いた処方では2か月で流れが不良に、2-メルカプトピリジン N-オキシドナトリウム25部を欠いた処方では２か月で流れが不良に、N-アセチル-N-ブチル-β-アラニンエチル25部を欠いた処方では２か月で流れが不良に、テトラデシル[3-(トリメトキシシリル)プロピル]ジメチルアミニウム・クロリド25部を欠いた処方では３か月で流れが不良になり調べたところ尿石が多量に付着していた。 It was washed and dried without being treated with the composition of Example 13 and then incorporated and used in the same manner as in Example 3. When the flow became poor in 2 months and the inner surface was observed, urine was obtained as shown in FIG. Stone growth was observed. Also, the formula lacking 25 parts of 2- (methoxycarbonylamino) -1H-benzimidazole has a poor flow in 2 months, and the formula lacking 25 parts of 2-mercaptopyridine N-oxide sodium has a flow in 2 months. Inadequately, a formula lacking 25 parts of N-acetyl-N-butyl-β-alanine ethyl gave a poor flow in 2 months, with 25 parts of tetradecyl [3- (trimethoxysilyl) propyl] dimethylaminium chloride. In the lack of prescription, the flow became poor in 3 months, and when examined, a large amount of urinary stones adhered.
Claims (6)
A method for preventing adhesion of urine stone, wherein the composition according to claim 1 or 2 is applied to the inner surface of a drain pipe of a urinal.
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| JP3294749B2 (en) * | 1995-12-06 | 2002-06-24 | 東洋紡績株式会社 | Bio-resistant molded article, method for producing the same, and product using the same |
| JP4416998B2 (en) * | 2001-11-19 | 2010-02-17 | 日本エンバイロケミカルズ株式会社 | Microbial control agent |
| US20050132500A1 (en) * | 2003-12-22 | 2005-06-23 | Basf Aktiengesellschaft | Composition for impregnation of fibers, fabrics and nettings imparting a protective activity against pests |
| JP2005298494A (en) * | 2004-03-18 | 2005-10-27 | Fumito Kumagai | Antibacterial, antifungal, algae-proofing and antimicrobial composition |
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