JP6581674B2 - Luminous treatment tool - Google Patents

Description

  The present invention relates to a light-emitting treatment tool used for photoimmunotherapy for treating an affected area by irradiating the affected area with light that reacts with the photosensitive material on the affected area.

  There are various treatment methods for cancer, and as one of them, in Patent Document 1 below, a cyanine dye having an immunopotentiating action is administered to a cancer nest and irradiated with a certain amount of light, so Photoimmunotherapy that enhances immune function has been described. In Patent Document 1, an apparatus for photoimmunotherapy is provided with a light source part, a light guide part, an injection part composed of a light introduction path and a chemical solution inflow path, and a laser oscillator or a light emitting diode is used as the light source part. Furthermore, a cancer treatment apparatus by photoimmunotherapy using a cyanine dye as a chemical solution is disclosed (see claims 1 to 3).

  In recent years, a new type of photoimmunotherapy (also referred to as near-infrared light immunotherapy) is being developed. In this photoimmunotherapy, a conjugate of an antibody and a light-absorbing substance (also referred to as a photosensitive substance; for example, IR700) is administered into the body by intravenous injection or the like, and this conjugate is attached to cancer cells, and then 700 By irradiating the human body with near-infrared light of about 850 nm, the light-absorbing substance absorbs the light and generates energy and heat, destroying only the cancer cells to which the conjugate is bound (the lipid duplex of the cancer cells) The membrane rapidly breaks down and leaks cytoplasmic contents, leading to necrosis).

JP-A-7-144026

  In the photoimmunotherapy in the above-mentioned Patent Document 1, since a laser oscillator is applied to the human body from the outside of the body, it cannot be treated unless it is a relatively large medical facility, which is a burden on the patient.

  In the near-infrared ray immunotherapy, near-infrared rays have been irradiated from outside the body so far, but there may be a case where a therapeutic effect may not be obtained sufficiently, and there is a need for a treatment device having a structure that can be placed in the body. It was. However, a treatment tool that can be placed in the body needs to be as compact as possible in consideration of invasiveness to the human body.

  An object of the present invention is to provide a light-emitting treatment device that can be placed in the body and can be subjected to photoimmunotherapy, and is easy to have a compact shape and size.

  The light-emitting treatment device of the present invention is used for photoimmunotherapy for treating an affected part by irradiating the affected part with light that reacts with the photosensitive substance on the affected part in the body. A power receiving coil that has a magnetic body and a coil wound around the outer periphery of the magnetic body, and generates power by a change in magnetic flux applied from an external power transmitting means; and a resonant capacitor connected to the power receiving coil; A light emitter that emits light that reacts with the photosensitive material by the electric power generated by the power receiver coil, and the power receiver coil, the resonant capacitor, and the light emitter are mounted on a flexible wiring board. The whole is covered with a cover, and the portion of the cover that is irradiated with light from the light emitter forms a light emitting portion that transmits light.

  According to the present invention, a light-emitting treatment tool is inserted into the body, and the light-emitting part of the light-emitting treatment tool is placed in contact with or in close proximity to the affected part to which a photosensitive substance is attached by a method such as an antigen-antibody reaction. By applying a change in magnetic flux from the power transmission means to generate power in the power receiving coil and causing the luminous body to emit light, a photosensitive substance attached to the affected area can be reacted to give a therapeutic effect to the affected area. In addition, since the power receiving coil, the resonant capacitor, and the light emitter are mounted on the flexible wiring board, the flexible wiring board is bent or bent so that the layout is compact and the light emitting surface is A light emitter can be installed so as to face a desired direction, and a light emitting treatment device having a compact shape and size can be obtained.

  As one aspect of the light emitting treatment device of the present invention, a plurality of the light emitters are mounted on the flexible wiring board. According to this aspect, by having a plurality of light emitters, the light emission intensity can be increased or light can be emitted in a plurality of directions.

  As one aspect of the light-emitting treatment device of the present invention, the cover has a capsule shape extending long in a predetermined direction, the flexible wiring board has a long plate shape, and one end portion in the longitudinal direction is L-shaped. A bent portion is provided, the light emitter is mounted on the outside of the bent portion and disposed at the front end portion of the cover, and the light emitting portion is provided at the front end portion of the cover. Yes. According to this aspect, since the light emitter is disposed outside the L-shaped bent portion of the flexible wiring board and the light emitter is located at the tip of the cover, the light emitting treatment tool can be further compacted. Can be planned. Moreover, since the light emitting part is provided at the front end of the cover, the light emitting part can be easily arranged toward the affected part.

  As one aspect of the light emitting treatment device of the present invention, the resonant capacitor is disposed inside the bent portion, and the flexible wiring board is on the opposite side of the bent portion with respect to the resonant capacitor. The power receiving coil is disposed at an adjacent position.

  According to this aspect, the resonance capacitor is disposed inside the bent portion, and the power receiving coil is disposed at a position adjacent to the flexible capacitor on the opposite side of the bent portion with respect to the resonant capacitor. Therefore, within the capsule-shaped cover, the light emitter, resonant capacitor, and power receiving coil can be arranged in an efficient layout that effectively uses the space in the cover, making the treatment device even more compact. Can be achieved.

  As one aspect of the light-emitting treatment device of the present invention, the cover is integrally formed so as to embed a flexible wiring board on which the power receiving coil, the resonant capacitor, and the light emitter are mounted. It is formed with the resin member which has.

  According to this aspect, each part can be firmly fixed, and the insulation can be enhanced and covered, and the whole is made constant by the resin member, so that excellent strength can be obtained. Moreover, manufacturing workability is good.

  As one aspect of the light emitting treatment device of the present invention, it further includes a tube stent having a tube shape, and the flexible wiring board is disposed so as to be wound around the tube stent in a cylindrical shape. A plurality of the light emitters are mounted at predetermined intervals along the outer periphery of the flexible wiring board.

  According to this aspect, since the flexible wiring board has a cylindrical shape that is arranged so as to be wound around the outer periphery of the tube stent, the light-emitting treatment tool in which the light emitter is mounted on the outer periphery of the tube stent can be easily obtained. Can be manufactured. Then, the light-emitting treatment tool is inserted into a tubular organ having an affected part such as cancer tissue on the inner wall, for example, so that the light-emitting treatment tool is placed in a state where the light-emitting part is in close contact with the affected part of the tubular organ. The therapy can be administered effectively.

  As an aspect of the light emitting treatment device of the present invention, the flexible wiring board is bent in a box shape, and the light emitter is mounted on the outer peripheral surface side of the flexible wiring board forming the box shape. According to this aspect, since the light emitter is mounted on the outer peripheral surface side of the box-shaped flexible wiring board, for example, the light-emitting treatment tool is swallowed to reach the affected part, or the light-emitting treatment tool is attached to the affected part. By arranging so as to be embedded in, it is possible to effectively irradiate the affected area with light.

In one embodiment of the light-emitting treatment device of the present invention, the illuminant has a radiant flux of luminescence intensity of 100 mW or more and a cumulative irradiation energy of 200 J / cm ² or more at an irradiation time of 100 hours. Has been.

According to this aspect, since the illuminant has a radiant flux of luminescence intensity of 100 mW or more and an irradiation time of 100 hours, the cumulative irradiation energy is 200 J / cm ² or more. In contrast, it is possible to irradiate light of a predetermined wavelength with sufficient light emission intensity and energy that is effective for photoimmunotherapy, and the therapeutic effect of photoimmunotherapy can be enhanced.

  As one aspect of the light-emitting treatment device of the present invention, photosensitive light is applied to the photosensitive material, which is placed in close contact with the affected area made of cancer tissue and selectively attached to the affected area, by the illuminant. Used for irradiation. According to this aspect, the photosensitive material selectively attached to the affected part made of cancer tissue can be effectively irradiated with the luminescent material in the vicinity of the photosensitive light over a long period of time. The cancer tissue can be effectively destroyed by the photoreaction of the photosensitive material.

  As one aspect of the light emitting treatment device of the present invention, the light emitting surface of the light emitter is arranged to be at a distance of 2 mm or less with respect to the inner surface of the light emitting portion of the cover.

  According to this aspect, the light emitting surface of the light emitter is mounted on the flexible wiring board so that the light emitting surface of the light emitter is at a distance of 2 mm or less with respect to the inner surface of the light emitting portion of the cover. The light-emitting treatment device can be arranged so as to be in the vicinity of the head, and the therapeutic effect of photoimmunotherapy can be further enhanced.

  As one aspect of the light emitting treatment device of the present invention, the outer surface of the light emitting portion of the cover is formed of a material that can be adhered to a biological adhesive having adhesiveness to the affected area.

  According to this aspect, since the outer surface of the light emitting part of the cover is formed of a material that can be adhered to a bioadhesive having adhesiveness to the affected part, for example, after the human body is incised, the affected part is treated. By placing the device and bonding the outer surface of the light emitting part of the cover and the affected part with the bioadhesive agent, the light emitting part can be placed in close contact with the affected part, and the therapeutic effect of photoimmunotherapy is further enhanced Can do.

  As one aspect of the light emitting treatment device of the present invention, an engagement means for engaging with the affected area is provided on the outer periphery of the cover.

  According to this aspect, since the engagement means that engages with the affected part is provided on the outer periphery of the cover, the cover can be used as it is for the placement operation of the treatment tool. By simply inserting the light-emitting treatment tool into the affected area, it can be engaged with the affected area by the engaging means, and the arrangement work of the light-emitting treatment tool can be speeded up.

  As one aspect of the light-emitting treatment device of the present invention, the magnetic body has a property of changing the magnetic permeability depending on temperature, and when the power receiving coil reaches a predetermined temperature or higher during power generation of the power receiving coil, the permeability is reduced. It is configured such that the power reception efficiency is lowered and the temperature is lowered due to the change in magnetic susceptibility.

  According to this aspect, the magnetic body has a property that the magnetic permeability changes depending on the temperature, and when the power receiving coil reaches a predetermined temperature or more during power generation of the power receiving coil, the power receiving efficiency is lowered due to the change in the magnetic permeability and the temperature is lowered. Therefore, it is possible to prevent the power receiving coil from exceeding a predetermined temperature, that is, to provide an overtemperature protection function.

  According to the present invention, a light-emitting treatment tool is inserted into the body, and the light-emitting part of the light-emitting treatment tool is placed in contact with or in close proximity to the affected part to which a photosensitive substance is attached by a method such as an antigen-antibody reaction. By applying a change in magnetic flux from the power transmission means to generate power in the power receiving coil and causing the luminous body to emit light, the photosensitive material attached to the affected area can be reacted to give a therapeutic effect to the affected area. In addition, since the power receiving coil, the resonant capacitor, and the light emitter are mounted on the flexible wiring board, the flexible wiring board is bent or bent so that the layout is compact and the light emitting surface is A light emitter can be installed so as to face a desired direction, and a light emitting treatment device having a compact shape and size can be obtained.

The perspective view which shows 1st Embodiment of the light emission type treatment tool of this invention. Cross-sectional explanatory drawing of the light emission type treatment tool of 1st Embodiment. The manufacturing process of the light emission type treatment tool of 1st Embodiment is shown, (a) is explanatory drawing of a 1st process, (b) is explanatory drawing of a 2nd process, (c) is explanatory drawing of a 3rd process. . The manufacturing process of the light emitting treatment tool of 1st Embodiment is shown, (a) is explanatory drawing of 4th process, (b) is explanatory drawing of 5th process, (c) is explanatory drawing of 6th process. . The manufacturing process of the light emitting treatment tool of 1st Embodiment is shown, (a) is explanatory drawing of 7th process, (b) is explanatory drawing of 8th process, (c) is explanatory drawing of 9th process. . Explanatory drawing which shows the use condition of the light emission type treatment tool of 1st Embodiment. The other shape of the cover in the light emission type treatment tool of 1st Embodiment is shown, (a) is explanatory drawing of 1st other shape, (b) is explanatory drawing of 2nd other shape, (c) is 3rd other shape. FIG. The perspective view which shows the circuit structure in the light emission type treatment tool of 1st Embodiment. The 2nd Embodiment of the light emission type treatment tool of this invention is shown, (a) is sectional explanatory drawing, (b) is a perspective view of a flexible wiring board and the light-emitting body etc. which were mounted in it. Explanatory drawing which shows the use condition of the light emission type treatment tool of 2nd Embodiment. 3 shows a third embodiment of the light emitting treatment device of the present invention, (a) is a cross-sectional explanatory view, (b) is a perspective view of a flexible wiring board and a light emitter mounted thereon, and (c) is (b). Fig. It is for demonstrating the over-temperature protection function of a receiving coil of the light emitting treatment tool of this invention, Comprising: (a) is the frequency in a power transmission means, and the amount of electric power received or the power receiving efficiency by the receiving coil of a light emitting treatment tool. (B) is a chart showing the relationship between magnetic permeability and temperature when the temperature characteristic of the magnetic body of the power receiving coil has a positive characteristic, and (c) is a temperature characteristic of the magnetic body of the power receiving coil. The chart which shows the relationship between magnetic permeability and temperature in case that has negative characteristics.

  Hereinafter, the first embodiment of the light emitting treatment device of the present invention will be described in more detail with reference to the accompanying drawings.

  1 is a perspective view of the light-emitting treatment device 10 of the first embodiment, FIG. 2 is a cross-sectional explanatory view of the light-emitting treatment device 10, and FIG. 3A is a view of the first embodiment. FIG. 3B is an explanatory diagram of the second process of the manufacturing process in the light emitting treatment device 10, FIG. 3B is an explanatory diagram of the second process of the manufacturing process, and FIG. FIG. 4A is an explanatory diagram of the fourth process of the manufacturing process, FIG. 4B is an explanatory diagram of the fifth process of the manufacturing process, and FIG. FIG. 5A is an explanatory diagram of the seventh process of the manufacturing process, FIG. 5B is an explanatory diagram of the eighth process of the manufacturing process, FIG. 5 (c) is an explanatory view of the ninth step of the manufacturing process, FIG. 6 is an explanatory view showing the use state of the light emitting treatment device of the first embodiment, and FIG. 7 is the first embodiment. The other shape of the light emitting treatment device cover (A) is an explanatory diagram of the first other shape, (b) is an explanatory diagram of the second other shape, (c) is an explanatory diagram of the third other shape, and FIG. 8 shows the light emitting type of the first embodiment. The perspective view which shows the circuit structure in a treatment tool is each shown.

  This light-emitting treatment device is a photoimmunotherapy (near-infrared ray immunotherapy) that treats an affected area by irradiating the affected area with light that reacts with the photosensitive material on the affected area. ). As shown in FIG. 6, the light-emitting treatment device 10 in this embodiment is placed in close contact with an affected area 200 made of cancer tissue, and selectively attached to the affected area 200 made of cancer tissue in advance by an antigen-antibody reaction. The photosensitive material is used to irradiate photosensitive light from the illuminant 50 of the light-emitting treatment device 10, react the photosensitive material with light, and kill cancer cells.

  As shown in FIGS. 1 and 2, the light-emitting treatment device 10 of the first embodiment includes a magnetic body 31 and a coil 33 wound around the outer periphery of the magnetic body 31, and includes an external power transmission means 20 (FIG. 8). The power receiving coil 30 that generates power by changing the magnetic flux applied from the reference), the resonant capacitor 40 connected to the power receiving coil 30, and the light emission that emits light that reacts with the photosensitive material by the power generated by the power receiving coil 30. The power receiving coil 30, the resonant capacitor 40, and the light emitting body 50 are mounted on the flexible wiring board 60 and are entirely covered with the cover 70.

  As shown in FIG. 1 and FIG. 2, the cover 70 in this embodiment extends in a predetermined direction and has a capsule shape in which the outer peripheral surfaces of the distal end portion 71 and the proximal end portion 73 in the longitudinal direction are formed in a curved shape. I am doing. The portion of the cover 70 that is irradiated with light from the light emitter 50 forms a light emitting portion 75 that transmits light. In addition, in the cover 70 of this embodiment, the light emission part 75 is provided in the front-end | tip part 71. FIG.

  Inside the cover 70 is accommodated a flexible wiring board 60 on which the power receiving coil 30, the resonant capacitor 40, and the light emitter 50 are mounted. As a result, the power receiving coil 30, the resonant capacitor 40, the light emitter 50, and The entire flexible wiring board 60 is covered with a cover 70. The flexible wiring board 60 is accommodated so that the light emitter 50 is positioned at the tip 71 of the cover 70, and is arranged so that the light emitting surface 51 of the light emitter 50 faces the inner surface of the light emitter 75. Has been. In this embodiment, as shown in FIGS. 1 and 2, the cover 70 is made of an integral resin having transparency that embeds the flexible wiring board 60 on which the power receiving coil 30, the resonant capacitor 40, and the light emitting body 50 are embedded. Is formed.

  However, the cover 70 is a capsule that accommodates the flexible wiring board 60 on which the power receiving coil 30, the resonant capacitor 40, and the light emitter 50 are mounted, and the cover 70, the power receiving coil 30, the resonant capacitor 40, and the light emitter 50 are mounted. It is good also as a structure which filled the resin material which has transparency in the clearance gap between the flexible wiring boards 60. FIG. Further, the gap between the cover 70 and the flexible wiring board 60 on which the power receiving coil 30, the resonant capacitor 40, and the light emitting body 50 are mounted may be hollow. In either case, it is preferable that the flexible wiring board 60 on which the resonant capacitor 40 and the light emitter 50 are mounted is fixed in a predetermined position in the cover 70.

  The cover 70 can be formed of, for example, a synthetic resin such as an epoxy resin or polycarbonate. In this embodiment, as shown in FIGS. 5A to 5C, the flexible wiring board 60 on which the power receiving coil 30, the resonant capacitor 40, and the light emitting body 50 are mounted is disposed in the molds 150 and 160. (Diagram (a)), the molds 150 and 160 are closed, and a transparent resin is injected into the molds (Diagram (b)). The molds 150 and 160 are opened, and the molded product is taken out (Diagram 1). (C)) Thereby, the cover 70 is formed. And the outer periphery of the both ends 71 and 73 of the cover 70 comprises a curved surface shape, and the whole cover has translucency.

  Note that portions other than the light emitting portion 75 of the cover 70 may be colored with a predetermined color. However, the portion of the cover 70 that is irradiated with light from the light emitter 50 needs to be light transmissive so that the light emitting portion 75 is provided. Further, as shown in FIG. 6, the cover 70 is preferably formed of a material that can adhere to the biological adhesive 300 having adhesion to the affected part 200 such as cancer tissue. In this case, at least the outer surface of the light emitting portion 75 of the cover 70 only needs to be formed of a material that can adhere to the biomedical adhesive 300.

  As shown in FIG. 2, the outer diameter X1 of the cover 70 (in other words, the outer diameter of the light emitting treatment device 10) is preferably 4 mm or less, and more preferably 3 mm or less. Furthermore, the length X2 along the axial direction of the cover 70 (in other words, the length of the light emitting treatment device 10) is preferably 8 mm or less, and more preferably 6 mm or less.

  Moreover, as shown to Fig.7 (a)-(c), a cover is good also as a shape which provided the engaging means to engage with the affected part 200 in the outer periphery.

  The cover 80 in FIG. 7A is provided with a protrusion 85 that protrudes obliquely toward the base end portion 83 side on the outer periphery of a portion close to the tip end portion 81. The end surface of the protrusion 85 on the base end portion 83 side of the cover 80 is perpendicular to the longitudinal direction of the cover 80. A plurality of the protrusions 85 may be provided at equal intervals in the circumferential direction of the cover 80, or may be provided annularly over the entire circumference of the cover 80. The light-emitting treatment instrument 11 including the cover 80 is disposed in the affected area 200 by engaging the protrusion 85 in the affected area 200 when the distal end portion 81 of the cover 80 is inserted into the affected area 200. That is, the projection 85 provided integrally with the cover 80 constitutes an engaging means for engaging with the affected part 200.

  In the cover 90 of FIG. 7B, the cross-section of the tip end portion 91 has a shape like an arrow, and the leading edge of the cover 90 has a sharp projection 95. The proximal end side of the distal end portion 91 forms a protrusion 97 that protrudes from the body portion of the cover 90. Note that the end surface of the protrusion 97 on the base end portion 93 side of the cover 90 is perpendicular to the longitudinal direction of the cover 90. The protrusions 97 may be composed of a plurality of protrusions that are evenly provided in the circumferential direction of the cover 90, or may have an annular shape over the entire periphery of the cover 90. The light-emitting treatment device 12 including the cover 90 is disposed in the affected area 200 by engaging the protrusion 97 in the affected area 200 when the distal end portion 91 of the cover 90 is inserted into the affected area 200. That is, the protrusion 97 serves as an engaging means for engaging with the affected part 200.

  The cover 100 in FIG. 7C protrudes obliquely toward the base end portion 103 side at a predetermined interval in the axial direction in the middle of the outer periphery between the tip end portion 101 and the base end portion 103. A plurality of protrusions 105 are provided. In addition, the end surface of each protrusion 105 on the base end portion 103 side of the cover 100 is perpendicular to the longitudinal direction of the cover 100. The protrusions 105 may be provided uniformly in the circumferential direction of the cover 100 or may be provided in an annular shape over the entire circumference of the cover 100. The light emitting treatment device 13 including the cover 100 is configured such that when the distal end portion 101 of the cover 100 is inserted into the affected part 200, a plurality of projections 105 provided in the axial direction are engaged in the affected part 200. Arranged in the affected area 200. That is, the protrusion 105 provided integrally with the cover 80 is an engaging means for engaging the affected part 200.

  As shown in FIGS. 1 and 2, the power receiving coil 30 in this embodiment has a substantially cylindrical magnetic body 31 and an annular shape attached to the outer circumferences of both ends of the magnetic body 31 in the longitudinal direction. And a coil 33 formed by winding a wire having a predetermined wire diameter in close contact with each other between the electrodes 35 and 35 on the outer periphery of the magnetic body 31 and between the electrodes 35 and 35. Has been. Both ends of the coil 33 are connected to electrodes 35 and 35, respectively. In addition, the magnetic body 31 is good also as a cylindrical shape which provided the through-hole inside.

  Further, as shown in FIG. 3A, the outer diameter X3 of the magnetic body 31 is preferably 3 mm or less, and more preferably 2 mm or less. Furthermore, the length X4 along the axial direction of the magnetic body 31 is preferably 5 mm or less, and more preferably 3 mm or less.

  The magnetic body 31 as described above can be formed from, for example, iron oxide, chromium oxide, cobalt, and ferrite, but the magnetic body 31 in the first embodiment has a property that the magnetic permeability changes with temperature. When the power receiving coil 30 generates power when the power receiving coil 30 reaches a predetermined temperature or more, the power receiving efficiency is lowered due to the change in the magnetic permeability, and the temperature is lowered. For example, the magnetic body 31 can be formed of a known temperature-sensitive magnetic ferrite or the like.

  Further, as described above, the coil 33 is formed by winding the conductive wires in close contact with each other. However, a coil may be formed by providing a gap between the conductive wires and winding the conductive wire around the outer periphery of the magnetic body. The wire diameter of the conducting wire is preferably 0.15 mm or less, more preferably 0.10 mm or less.

  The power receiving coil 30 having the above structure is mounted on the flexible wiring board 60. The flexible wiring board 60 has flexibility (flexibility) and can be bent. The flexible wiring board 60 may be a printed board. The flexible wiring board 60 in this embodiment has a long plate shape, and one end portion in the longitudinal direction thereof is bent into an L shape, and a bent portion 63 is provided. That is, the flexible wiring board 60 includes a base 61 that extends in a long plate shape with a predetermined length, and a bent portion 63 that extends from one end in the longitudinal direction of the base 61 at a right angle with respect to the base 61. Consists of.

  As shown in FIGS. 1 and 2, the power receiving coil 30 has an axial direction arranged along the length direction of the flexible wiring board 60, and the power receiving coil 30 is connected via the pair of electrodes 35, 35. The flexible wiring board 60 is mounted on the inner surface (surface near the inner side of the bent portion 63) of the base 61. The flexible wiring board 60 is printed with a wiring pattern for connecting the pair of electrodes 35, 35 of the power receiving coil 30, the resonant capacitor 40, and the plurality of light emitters 50, although not particularly illustrated. Each component 30, 40, 50 is connected to the wiring pattern by a conductive solder, a conductive adhesive, or the like.

  Further, as shown in FIG. 1, a plurality of light emitters 50 in this embodiment are mounted on the outside of the bent portion 63 of the flexible wiring board 60 (the side facing the front end portion 71 of the cover 70). Here, the pair of light emitters 50 and 50 are arranged in parallel in the width direction (direction orthogonal to the longitudinal direction) of the bent portion 63, and the light emitting surface that is the light emitting surface of each light emitter 50. 51 is arranged at a predetermined distance X5 with respect to the outer surface of the light emitting portion 75 provided at the tip portion 71 of the cover 70. The distance X5 (see FIG. 2) between the light emitting surface 51 of the light emitter 50 and the outer surface of the light emitting portion 75 of the cover 70 is preferably a distance of 2 mm or less, more preferably a distance of 1 mm or less. Three or more light emitters 50 may be arranged side by side.

The light emitter 50 is a so-called light emitting diode (LED). In addition, as shown in FIG. 6, the luminescent treatment tool 10 is arranged in close contact with an affected area 200 that is a cancer tissue, and luminescent material 50 emits photosensitive light to a photosensitive material that is selectively attached to the affected area 200. Irradiation is performed to perform photoimmunotherapy for treating the affected area 200. For example, IR700 can be used as a photosensitive substance at this time. In this case, the light irradiated by the light emitter 50 is, for example, near infrared light having a wavelength of 680 to 700 nm. In addition, the luminous body 50 has a radiant flux with an emission intensity of preferably 100 mW or more, and an accumulated (accumulated) irradiation energy with an irradiation time of 100 hours is preferably 200 J / cm ² or more. Has been. In addition, when performing photoimmunotherapy to the affected part 200 using the luminescent treatment tool 10, the light emitter 50 can continue irradiation to the affected part 200 for 100 hours or more with the above-described radiant flux. Is preferred.

  Further, as shown in FIGS. 1 and 2, the resonance capacitor 40 is arranged on the inner side of the bent portion 63 (the side facing the base end portion 73 of the cover 70) of the flexible wiring board 60. In addition, as shown in FIG. 2, the position of the flexible wiring substrate 60 adjacent to the resonance capacitor 40 on the side opposite to the bent portion 63, that is, the inner surface of the base 61 constituting the flexible wiring substrate 60 (power reception) The power receiving coil 30 is disposed via a pair of electrodes 35 at a position adjacent to the resonance capacitor 40 with a predetermined gap therebetween.

  As described above, in the light emitting treatment device 10 of the first embodiment described above, each member is mounted at a predetermined position of the flexible wiring board 60 bent in an L shape as shown in FIG. Thus, the power receiving coil 30, the resonant capacitor 40, and the pair of light emitters 50 and 50 are configured to be mounted on the same line along the length direction of the flexible wiring board 60. In the state, the resonance capacitor 40 is arranged to face one end of the power receiving coil 30 with a predetermined interval.

  FIG. 8 shows a circuit diagram of the light emitting treatment device 10 of this embodiment. As shown in FIG. 8, a resonant capacitor 40 and a pair of light emitters 50 and 50 are connected in parallel to both ends of the power receiving coil 30. A pair of light emitters 50 and 50 are connected to the resonance capacitor in opposite directions, and these are connected in parallel to the resonance capacitor 40 and the power receiving coil 30. Further, the power transmission means 20 shown in FIG. 8 is formed by winding a conducting wire so as to form a spiral, and has a structure in which a resonant capacitor 21 and an inverter circuit 23 are connected. When AC power is supplied to the power transmission means 20 arranged outside the body, the power receiving coil 30 of the light-emitting treatment device 10 generates power due to the change in the magnetic flux. That is, when AC power is supplied to the power transmission means 20 and a magnetic field is generated, the magnetic flux is electromagnetically induced toward the power receiving coil 30 of the light emitting treatment device 10 and is wirelessly fed. Thus, the plurality of light emitters 50 irradiate near infrared light having a predetermined wavelength.

  The light emitting treatment device 10 having the above structure can be manufactured, for example, by the steps as shown in FIGS.

  That is, as shown in FIG. 3B, electrodes 35 and 35 are attached to the magnetic body 31 shown in FIG. Thereafter, a coil 33 is formed by winding a conducting wire between the pair of electrodes 35 and 35 on the outer periphery of the magnetic body 31, and both ends of the coil 33 are connected to the electrodes 35 and 35, respectively. The coil 30 is manufactured. In addition, after winding the conducting wire around the outer periphery of the magnetic body 31 to form the coil 33, the power receiving coil 30 may be manufactured by attaching the electrodes 35 and 35 so as to be in contact with both ends of the coil 33.

  On the other hand, as shown in FIG. 4 (a), a pair of plates are formed on one surface of the tip portion (the portion that becomes the bent portion 63) of the flexible wiring board 60, which has a long plate shape and a predetermined wiring pattern printed in advance. The light emitters 50 and 50 are arranged and mounted on the flexible wiring board 60 by known reflow soldering.

  After that, as shown in FIG. 4B, the resonant capacitor 40 is disposed on the other surface (the surface opposite to the surface on which the light emitters 50 and 50 are disposed) of the distal end portion of the flexible wiring board 60, and a pair The receiving coil 30 is disposed via the electrodes 35 and 35, and the resonant capacitor 40 and the receiving coil 30 are mounted on the flexible wiring board 60 by reflow soldering.

  In addition, you may perform connection of each components 30,40,50 with respect to the flexible wiring board 60 not with reflow soldering as mentioned above but with a conductive adhesive etc., for example. Moreover, in this embodiment, after mounting the light emitter 50 on the flexible wiring board 60, the resonant capacitor 40 and the power receiving coil 30 are mounted. In this case, the solder used may have a different melting point. preferable. For example, as shown in FIG. 4A, when the light emitter 50 is mounted on the flexible wiring board 60, high melting point solder is used, and the flexible wiring board 60 receives power as shown in FIG. 4B. When the coil 30 or the resonant capacitor 40 is mounted, eutectic solder having a lower melting point than that used when the light emitter 50 is mounted on the flexible wiring board 60 can be used.

  Then, from the state shown in FIG. 4B, the bent portion 63 is bent so as to form an L shape with respect to the base portion 61, and as shown in FIG. A pair of light emitters 50, 50 are disposed outside the portion 63, the resonant capacitor 40 is disposed inside the bent portion 63, and one end portion of the power receiving coil 30 disposed on the inner surface side of the base portion 61. Thus, the resonance capacitor 40 is disposed to be opposed to each other with a predetermined interval.

  As described above, a plurality of flexible wiring boards 60 on which the power receiving coil 30, the resonant capacitor, and the light emitting body 50 are mounted are prepared. Then, as shown in FIG. 5 (a), a pair of upper and lower injection molds 150 and 160 having an inner peripheral shape for forming the outer peripheral shape of the cover 70 and capable of moving close to and away from each other. Each flexible wiring board 60 is set. In this state, as shown in FIG. 5A, the base end 65 of the flexible wiring board 60 is supported on the support portion 165 of the mold 160.

  Next, as shown in FIG. 5B, the pair of molds 150 and 160 are brought close to each other, and the base end 65 of the flexible wiring board 60 supported by the support portion 165 of the mold 160 is sandwiched between the pair of molds. The molds 150 and 160 are closed. In this state, a transparent resin material is filled into the cavities 170 of the molds 150 and 160. As a result, the entire flexible wiring board 60 on which the power receiving coil 30, the resonant capacitor 40, and the light emitter 50 are mounted is embedded in a transparent resin material and covered with a cover 70 made of a transparent resin material. 10 can be manufactured (see FIG. 5B). Thereafter, by opening the pair of molds 150 and 160, the light emitting treatment device 10 is taken out of the mold, and the protruding portion of the flexible wiring board 60 connecting the light emitting treatment devices 10 is cut and separated. Thus, the light emitting treatment device 10 can be manufactured (see FIG. 5C). In FIGS. 1, 2, and 6, for the sake of convenience, the base end 65 of the flexible wiring board 60 embedded in the front end side of the cover 70 is omitted.

  As described above, in this embodiment, the cover 70 is integrally formed by injection molding. For example, the cover is formed as a capsule formed of two halved capsule bodies, and each capsule body is provided with one capsule body. After inserting the flexible wiring board on which the member is mounted, the other capsule body may be covered to accommodate the flexible wiring board in the cover. In this case, the two half-shaped capsule bodies may be divided in the vertical direction along the axial direction, or may be divided so as to cross the middle in the axial direction.

  Further, in this embodiment, the magnetic body 31 constituting the power receiving coil 30 has a property that the magnetic permeability changes depending on the temperature. When the power receiving coil 30 reaches a predetermined temperature or more during power generation of the power receiving coil 30, the magnetic permeability is increased. The power receiving efficiency is lowered by the change in the temperature, and the temperature is lowered. Thereby, an over-temperature protection function is provided to prevent the power receiving coil 30 from exceeding a predetermined temperature. As such a magnetic body 31, for example, temperature-sensitive magnetic ferrite or the like can be used. However, since many magnetic materials generally have a characteristic that the magnetic permeability changes more or less depending on the temperature, even when using an ordinary magnetic material, for example, the following configuration is adopted. Thus, an overtemperature protection function can be provided.

That is, there is a Q value as a value indicating the sharpness of the peak of the resonance frequency characteristic of the resonance circuit constituted by the power receiving coil 30 and the resonance capacitor 40 employed in the light emitting treatment device. It is shown by Formula 1. Here, ω is an angular frequency (rad / s), L is an inductance (H) of the receiving coil 30, R is a resistance (Ω) of the receiving coil 30, and f is a resonance frequency (Hz).

  When the above-mentioned Q value is high, as shown in FIG. 12 (a), if the frequency deviates even within a certain range (here, power reception efficiency of 95%), the amount of power reception decreases rapidly (peaky). Property). In addition, the horizontal axis of Fig.12 (a) is the frequency (Hz) in the power transmission means 20, and the vertical axis | shaft has shown the amount of electric power received or the electric power reception efficiency by the receiving coil 30 of a light emission type treatment tool. That is, when the frequency in the power transmission means 20 and the frequency in the power receiving coil 30 of the light emitting treatment device can be substantially matched, a high power reception amount can be obtained and the light emitter 50 can emit light sufficiently. However, if this is not the case, the amount of power received is drastically reduced, so that the light emitter 50 cannot emit light, and sufficient light emission intensity cannot be obtained even if light can be emitted.

  FIG. 12B shows the relationship between the magnetic permeability and the temperature when the temperature characteristic of the magnetic body 31 of the receiving coil 30 has a positive characteristic (the property that the magnetic permeability increases as the temperature rises). FIG. 12C shows the relationship between the magnetic permeability and the temperature when the temperature characteristic of the magnetic body 31 of the receiving coil 30 has a negative characteristic (a property that the magnetic permeability decreases as the temperature rises). Yes. In addition, when the frequencies at the power reception efficiency of 95% in FIG. 12A are “a” and “b” and are applied in correspondence to FIGS. 12B and 12C, “a” and “b” are applied. The magnetic permeability at “b” is defined as “μa” and “μb”. Further, the magnetic body 31 has a magnetic permeability of “μa” when the temperature is 25 to 35 ° C., and a magnetic permeability of “μb” when the temperature is 42 ° C. Therefore, when the power transmitted from the power transmission means 20 increases and the temperature of the power receiving coil 30 tends to exceed 42 ° C., the amount of power received decreases rapidly, so the temperature of the power receiving coil 30 becomes 42 ° C. or higher. It is possible to prevent the temperature rise and exert the overtemperature protection function.

  Next, functions and effects of the light emitting treatment device 10 of the present invention will be described.

  First, in other words, a conjugate of an antibody and a photosensitive substance (for example, IR700) is administered into the body by intravenous injection or the like, and this conjugate is attached to the affected area 200 (here, a cancer cell). Thereafter, the luminescent treatment tool 10 is applied to the affected part 200 (here, cancer tissue) in the body by incising the human body or by a known method using a plurality of sheaths, catheters, or the like. The light emitting portion 75 of the cover 70 is placed in contact with or in close proximity. In addition, since the light emitting treatment device 10 has a capsule shape, it may be swallowed from the mouth to reach the affected area. Here, as shown in FIG. 6, the tip of the light-emitting treatment instrument 10 (tip 71 of the cover 70) is inserted into the affected part 200 with the light emitter 50 facing the affected part 200, and the cover protruding from the affected part 200 is used. The light emitting treatment tool 10 is disposed by bonding the outer peripheral portion of 70 and the affected part 200 with the biomedical adhesive 300. At this time, as shown in FIG. 6, a plurality of light emitting treatment devices 10 may be arranged. For example, the pair of light emitting treatment devices 10 and 10 may be arranged such that the distal end portions 71 and 71 of the cover 70 provided with the light emitting portion 75 face each other.

  Then, AC power is supplied to the power transmission means 20 arranged outside the human body, thereby generating a changing magnetic field, and the magnetic flux is electromagnetically induced in the power receiving coil 30 of the light emitting treatment device 10, and by wireless power feeding The power receiving coil 30 generates electric power, and the plurality of light emitters 50 irradiate light of a predetermined wavelength, for example, near infrared light by the electric power. As a result, a photosensitive substance such as IR700 attached to the affected area 200 can be reacted, and photoimmunotherapy can be performed on the affected area 200 to impart a therapeutic effect to the affected area 200.

  In the light emitting treatment device 10, as shown in FIG. 1 and FIG. 2, the power receiving coil 30, the resonant capacitor 40, and the light emitter 50 are mounted on the flexible wiring board 60. By bending or bending the substrate 60, the light emitter 50 can be installed so that the layout is compact and the light emitting surface 51 faces a desired direction, and the light emission has a compact shape and size. The mold treatment tool 10 can be obtained. In the light emitting treatment device 10, the power receiving coil 30, the resonant capacitor 40, and the light emitter 50 are mounted on the flexible wiring board 60, and these are connected via the wiring printed on the flexible wiring board 60. Since it is connected, there is no need for complicated and troublesome work such as connecting the power receiving coil 30, the resonant capacitor 40, and the light emitting body 50 via a conductive wire, and the productivity of the light emitting treatment device 10 is increased and the manufacturing cost is increased. Can be reduced.

  Further, as shown in FIG. 1, in the light emitting treatment device 10, a plurality of light emitters 50 (here, a pair of left and right light emitters 50, 50) are mounted on a flexible wiring board 60. Thus, by having a plurality of light emitters 50, the light emission intensity can be increased or light can be emitted in a plurality of directions.

  Further, as shown in FIGS. 1 and 2, in the light emitting treatment device 10, the cover 70 has a capsule shape extending long in a predetermined direction, and the flexible wiring board 60 has a long plate shape, and its longitudinal direction. 1 is bent into an L-shape, and a bent portion 63 is provided. A light emitter 50 is attached to the outside of the bent portion 63 and is disposed at the distal end portion 71 of the cover 70. The light emitting part 75 is provided in the part 71. Thus, since the light emitter 50 is disposed outside the L-shaped bent portion 63 of the flexible wiring board 60 and the light emitter 50 is located at the distal end portion 71 of the cover 70, the light emitting treatment tool 10. Further downsizing can be achieved. Further, since the light emitting portion 75 is provided at the distal end portion 71 of the cover 70, the light emitting portion 75 can be easily arranged toward the affected area 200.

  Further, as shown in FIGS. 1 and 2, the resonance capacitor 40 is disposed inside the bent portion 63, and adjacent to the bent portion 63 of the flexible wiring board 60 with respect to the resonance capacitor 40. The power receiving coil 30 is disposed at the position. Therefore, the light emitter 50, the resonant capacitor 40, and the power receiving coil 30 can be arranged in an efficient layout that effectively uses the space in the cover 70 in the capsule-shaped cover 70. The mold treatment tool 10 can be further downsized.

In addition, the luminous body 50 has a radiant flux of 100 mW or more and a cumulative irradiation energy of 200 J / cm ² or more at an irradiation time of 100 hours. Thus, it is possible to irradiate light of a predetermined wavelength with sufficient light emission intensity and energy that is effective for photoimmunotherapy, and the therapeutic effect of photoimmunotherapy can be enhanced. Further, since the accumulated irradiation energy is set to 200 J / cm ² or more when the irradiation time is 100 hours, it is not necessary to cause the light emitter 50 to emit light continuously, and intermittently for a predetermined time. Since it is sufficient to emit only light and the cumulative irradiation time is 100 J / cm ² or more, treatment is simplified and the burden on the patient can be reduced. For example, by installing the power transmission means 20 at home and emitting light at a desired timing of the patient (such as during sleep), treatment can be performed at home, and even if the patient is not admitted to the hospital, You can also receive treatment for a predetermined time. As described above, since it is possible to easily perform treatment anytime and anywhere at the timing desired by the patient, the burden on the patient can be reduced.

  Further, the light-emitting treatment tool 10 is disposed in close contact with the affected part 200 made of cancer tissue, and irradiates the photosensitive material selectively attached to the affected part 200 with the light emitting body 50 so as to emit photosensitive light. It is used for. Therefore, the photosensitive material selectively attached to the affected area 200 made of cancer tissue can be effectively irradiated with photosensitive light over a long period of time by the luminous body 50, so that the irradiation energy is increased. The cancer tissue can be effectively destroyed by the photoreaction of the photosensitive material.

  Further, as shown in FIG. 2, in the luminescent treatment device 10, the light emitting surface 51 of the light emitter 50 has a distance of 2 mm or less (see X <b> 5 in FIG. 2) with respect to the outer surface of the light emitting portion 75 of the cover 70. It is arranged to be. Therefore, the light-emitting treatment tool 10 can be disposed so that the light emitting surface 51 of the light emitter 50 is located close to the affected part 200, and the therapeutic effect of photoimmunotherapy can be further enhanced.

  In addition, as shown in FIG. 6, in the light emitting treatment device 10, the outer surface of the light emitting portion 75 of the cover 70 is formed of a material that can be bonded to a living body adhesive 300 that has adhesiveness to the affected area 200. ing. Therefore, for example, after incising the human body, the light-emitting treatment tool 10 is disposed in the affected part 200, and the affected part 200 is adhered to the outer surface of the light emitting part 75 of the cover 70 and the affected part 200 with the biological adhesive 300. The light emitting unit 75 can be disposed in close contact with the 200, and the therapeutic effect of photoimmunotherapy can be further enhanced.

  As shown in FIGS. 7A to 7C, the light-emitting body treatment tool 11, 12 has a shape in which engagement means for engaging with the affected part 200 is provided on the outer periphery of the covers 80, 90, 100. , 13 has the following effects. That is, in order to dispose these light-emitting treatment tools 11, 12, and 13 in the affected area 200, the distal end side (the side where the light emitter 50 is installed) is inserted into the affected area 200, and the protrusions 85, 95, 97, Since the protrusions 85, 95, and 105 are engaged with the inside of the affected part 200 by being pushed in until the 105 is located in the affected part 200, the light emitting treatment tools 11, 12, and 13 are arranged in close contact with the affected part 200. Can do. As described above, since the engaging means for engaging with the affected area 200 is provided on the outer periphery of the covers 80, 90, 100, the cover 80, 90, 100 is placed as it is with the light-emitting treatment tools 11, 12, 13 as it is. For example, after the human body is incised, the light emitting treatment tool 11, 12, 13 is simply inserted into the affected part 200 and pushed in, and the protrusions 85, 95, It is possible to engage with the affected part 200 through 97 and 105, and to speed up the arrangement work of the light emitting treatment devices 11, 12, and 13. Further, the projections 85, 97, 105 provided on the covers 80, 90, 100 have a return shape like a fishhook extending obliquely toward the base end portions 83, 93, 103 side, so that the affected part Even if the light-emitting treatment tool 11, 12, 13 is about to come out from 200, the light-emitting treatment tool 11, 12, 13 is caught inside the affected part 200, so that each light-emitting type treatment tool 11, 12, 13 is not easily removed from the affected part 200 and is easily maintained at a predetermined position. The effect is obtained.

  Furthermore, since the light emitting treatment devices 11, 12, and 13 shown in FIGS. 7A to 7C have the projections 85, 97, and 105 as described above, for example, the treatment devices 11, 12, 13 is accommodated in a syringe, the injection needle is inserted into the affected area, and each treatment tool 11, 12, 13 is pushed in from the distal end side, so that the projections 85, 97, 105 of each treatment tool 11, 12, 13 are affected. In order to engage inside, each treatment tool 11,12,13 can be directly inserted and arranged in an affected part from outside the body. In the case of the light emitting treatment device 12, since the tip 91 of the distal end portion 91 has a sharp projection 95, it is particularly easy to insert when inserting directly into the affected area from outside the body as described above.

  Further, in the light emitting treatment device 10, the magnetic body 31 constituting the power receiving coil 30 has a property of changing the magnetic permeability depending on the temperature, and when the power receiving coil 30 generates power, the power receiving coil 30 is not less than a predetermined temperature. Then, the power reception efficiency is lowered due to the change in magnetic permeability, and the temperature is lowered. As described above, the magnetic body 31 has a property that the magnetic permeability changes depending on the temperature. When the power receiving coil 30 reaches a predetermined temperature or more during power generation of the power receiving coil 30, the power receiving efficiency is lowered due to the change in the magnetic permeability. Therefore, it is possible to prevent the power receiving coil 30 from exceeding a predetermined temperature, that is, to provide an overtemperature protection function.

  Next, a second embodiment of the light emitting treatment device of the present invention will be described in detail with reference to FIGS. 9 and 10.

  9A is a cross-sectional explanatory view of the light emitting treatment device of the second embodiment, FIG. 9B is a perspective view of a flexible wiring board and a light emitter mounted thereon, and FIG. Explanatory drawing which shows the use condition of the light emission type treatment tool of 2nd Embodiment is each shown.

  As shown to Fig.9 (a), the light emission type treatment tool 14 of this 2nd Embodiment has the tube stent 180 which made the tube shape. The tube stent 180 has a plurality of bodily fluid circulation holes 181 formed at both ends in the length direction, and can pass bodily fluids through the internal space of the tube stent 180. Further, spirally engaging portions 181 and 181 are provided on the end side of the tube stent 180 in the length direction from the bodily fluid circulation hole 181, respectively. (In FIG. 10, for convenience of explanation, it is not locked to the inner wall 220 in the body, but it may be locked to the inner wall 220).

  Further, as shown in FIG. 9B, the flexible wiring board 66 of this embodiment has a rectangular plate shape having a predetermined width and a predetermined length, and has a cylindrical shape on the outer periphery of the tube stent 180. And is formed in a substantially cylindrical shape. A plurality of light emitters 50 are mounted at predetermined intervals along the outer periphery of the flexible wiring board 66 at predetermined locations on the surface (cylindrical outer surface side), and the resonant capacitor 40 and the power receiving coil 30 are also mounted. Has also been implemented. The magnetic body 31 constituting the power receiving coil 30 has a cylindrical shape, and the flexible wiring board 66 is inserted in a rolled state on the inner periphery thereof, and the magnetic body 31 is disposed on the outer periphery of the flexible wiring board 66. It is like that. A coil 33 is formed on the outer periphery of the magnetic body 31, and end lines 33 a and 33 a extending from both longitudinal ends of the coil 33 are connected to the electrodes 35 and 35. Furthermore, as shown in FIG. 9A, a cylindrical flexible wiring board 66 on which the power receiving coil 30, the resonant capacitor 40, and the plurality of light emitters 50 are mounted is wound around the outer periphery of the tube stent 180 to apply an adhesive or the like. The outer periphery of the flexible wiring board 66 is covered with a cover 77 made of an integral resin having transparency. Further, a portion of the cover 77 corresponding to the plurality of light emitters 50 forms a light emitting unit 75.

  As described above, according to the light emitting treatment device 14 of this embodiment, the flexible wiring board 66 has a cylindrical shape arranged so as to be wound around the outer periphery of the tube stent 180. The light emitting treatment device 14 having a plurality of light emitters 50 mounted on the outer periphery can be easily manufactured.

  In addition, the light-emitting treatment instrument 14 is inserted into a tubular organ through an endoscope, a catheter, or the like so as to perform photoimmunotherapy on an affected part 200 such as cancer tissue generated on the inner wall 220 of the tubular organ. Thus, the plurality of light emitters 50 are arranged on the inner periphery of the affected part 200. At this time, in this luminescent treatment tool 14, by inserting it into the tubular organ as described above, the luminescent part 75 can be placed in close contact with the affected part 200, so that photoimmunotherapy is effective. Can be applied.

  Next, a third embodiment of the light emitting treatment device of the present invention will be described in detail with reference to FIG.

  11A is a cross-sectional explanatory view of the light emitting treatment device of the third embodiment, FIG. 11B is a perspective view of the flexible wiring board and the light emitter mounted thereon, and FIG. 11C is FIG. Each development is shown in FIG.

  As shown in FIG.11 (c), the flexible wiring board 67 in the light emitting treatment tool 15 of this embodiment has the 1st surface 67A which made the rectangular shape, The upper side of this 1st surface 67A, a right side The second surface 67B, the third surface 67C, the fourth surface 67D, and the fifth surface 67D, which are the same shape as the first surface 67A, are formed on the lower side and the left side through the folding line 68, respectively. When unfolded, it has a cross shape. In addition, the light emitter 50 is mounted on each of the surfaces 67A, 67B, 67C, 67D, and 67E, and the resonant capacitor 40 is mounted on the third surface 67C at a position adjacent to the light emitter 50. .

  Then, as shown in FIG. 11 (b), the respective surfaces 67B, 67C, 67D, and 67E are bent with respect to each side of the first surface 67A via a plurality of bending lines 68, respectively. A flexible wiring board 67 bent into a box shape as shown in FIG. Further, the receiving coil 30 is mounted in a state where the end of the flexible wiring board 67 bent in a box shape is in contact with the first surface 67A (the end thereof is in contact with the first surface 67A) ( (See FIG. 11 (a)).

  In the light emitting treatment tool 15 of the third embodiment, since the plurality of light emitters 50 are mounted on the outer peripheral surface side of the box-shaped flexible wiring board 67, the light emitting treatment tool 15 is attached to the affected part 200. It is possible to effectively irradiate the affected area 200 with light by placing it so as to be embedded in the body or by swallowing the luminescent treatment tool 15 from the mouth and reaching the affected area 200 such as the digestive system.

  The aspect of the present invention described above is not limited to the embodiment. That is, various modified embodiments are possible within the scope of the gist of the present invention, and these modified embodiments are also included in the scope of the present invention.

10, 11, 12, 13, 14, 15 Light emitting treatment device 20 Power transmission means 21 Resonant capacitor 23 Inverter circuit 30 Power receiving coil 31 Magnetic body 33 Coil 33a End wire 35 Electrode 40 Resonant capacitor 50 Light emitting body 51 Light emitting surface 60, 66, 67 flexible wiring board 61 base 63 bent part 65 base end 66 flexible wiring board 67 flexible wiring board 67A first surface 67B second surface 67C third surface 67D fourth surface 67E fifth surface 68 bending lines 70, 78, 80, 90, 100 Cover 71, 81, 91, 101 Tip portion 73, 83, 93, 103 Base end portion 75 Light emitting portion 77 Cover 85, 93, 95, 105 Protrusion 150, 160 Mold 165 Support portion 170 Cavity 180 Tube stent 181 Body fluid circulation hole 181 Locking part 200 Affected part 220 Inner wall 300 -Body adhesive

Claims (12)

A luminescent treatment tool used in photoimmunotherapy for treating an affected area by irradiating the affected area with light that reacts with the photosensitive substance in the body with respect to the photosensitive substance attached to the affected area,
A power receiving coil that has a magnetic body and a coil wound around the outer periphery of the magnetic body, and generates power by a change in magnetic flux applied from an external power transmitting means;
A resonant capacitor connected to the power receiving coil;
A light emitter that emits light that reacts with the photosensitive material by the power generated by the power receiving coil;
The power receiving coil, the resonant capacitor, and the light emitter are mounted on a flexible wiring board, and the whole is covered with a cover,
The portion of the cover that is irradiated with light from the light emitter forms a light emitting portion that transmits light ,
The cover has a capsule shape extending long in a predetermined direction,
The flexible wiring board has a long plate shape, one end portion in the longitudinal direction thereof is bent in an L shape, and a bent portion is provided.
A light-emitting treatment device , wherein the light emitter is attached to the outside of the bent portion and is disposed at a distal end portion of the cover, and the light emitting portion is provided at the distal end portion of the cover . A luminescent treatment tool used in photoimmunotherapy for treating an affected area by irradiating the affected area with light that reacts with the photosensitive substance in the body with respect to the photosensitive substance attached to the affected area,
A power receiving coil that has a magnetic body and a coil wound around the outer periphery of the magnetic body, and generates power by a change in magnetic flux applied from an external power transmitting means;
A resonant capacitor connected to the power receiving coil;
A light emitter that emits light that reacts with the photosensitive material by the power generated by the power receiving coil;
The power receiving coil, the resonant capacitor, and the light emitter are mounted on a flexible wiring board, and the whole is covered with a cover,
The portion of the cover that is irradiated with light from the light emitter forms a light emitting portion that transmits light ,
Furthermore, it has a tube-shaped tube stent,
The flexible wiring board is arranged so as to be wound around the outer circumference of the tube stent, and a plurality of the light emitters are mounted at predetermined intervals along the outer circumference of the flexible wiring board. Luminous treatment tool. A luminescent treatment tool used in photoimmunotherapy for treating an affected area by irradiating the affected area with light that reacts with the photosensitive substance in the body with respect to the photosensitive substance attached to the affected area,
A power receiving coil that has a magnetic body and a coil wound around the outer periphery of the magnetic body, and generates power by a change in magnetic flux applied from an external power transmitting means;
A resonant capacitor connected to the power receiving coil;
A light emitter that emits light that reacts with the photosensitive material by the power generated by the power receiving coil;
The power receiving coil, the resonant capacitor, and the light emitter are mounted on a flexible wiring board, and the whole is covered with a cover,
The portion of the cover that is irradiated with light from the light emitter forms a light emitting portion that transmits light ,
The flexible wiring board is bent in a box shape, and the luminous body is mounted on an outer peripheral surface side of the flexible wiring board forming the box shape . The light emitting treatment tool according to any one of claims 1 to 3 , wherein a plurality of the light emitters are mounted on the flexible wiring board. The resonant capacitor is disposed inside the bent portion,
Wherein the flexible wiring board, wherein at a position adjacent to the side opposite to the bent portion, wherein the receiving coil is disposed, emitting treatment device of claim 1, wherein with respect to said resonant capacitor. The light emitter is a radiant flux of the light emission intensity is above 100 mW, and, in the irradiation time of 100 hours, the irradiation energy of the accumulated is such that the 200 J / cm ² or more, any one of claims 1 to 5 The light emitting treatment device according to Item 1. Are arranged in close contact with the affected area consisting of cancerous tissue, the photosensitive material is selectively deposited on the diseased part, by the light emitters is used to irradiate the photosensitive light, according to claim 1 to 6 The light emitting treatment device according to any one of the above. The light emitting treatment tool according to any one of claims 1 to 7 , wherein a light emitting surface of the light emitter is disposed at a distance of 2 mm or less with respect to an inner surface of the light emitting portion of the cover. . The light emitting type according to any one of claims 1 to 8 , wherein an outer surface of the light emitting part of the cover is formed of a material that can be adhered to a bioadhesive having adhesiveness to the affected part. Treatment tool. The light-emitting treatment tool according to any one of claims 1 to 9 , wherein engagement means for engaging with the affected part is provided on an outer periphery of the cover. The magnetic body has a property that magnetic permeability changes depending on temperature, and when the power receiving coil reaches a predetermined temperature or more during power generation of the power receiving coil, the power receiving efficiency decreases due to the change in the magnetic permeability and the temperature decreases. It is configured to, emitting treatment device according to any one of claims 1-10. The cover is formed of a transparent resin member that is integrally formed so as to embed a flexible wiring board on which the power receiving coil, the resonance capacitor, and the light emitter are mounted. The luminescent treatment device according to any one of to 11 .