JP6562414B2 - Cream for applying radiation to skin and method for producing the same - Google Patents

Description

The present invention relates to a cream, and a manufacturing method thereof hormesis effect.

  Generally, radiation is a flow of energy released at a high speed. Among these, a substance having sufficient energy to ionize a substance is called ionizing radiation. During radioactive decay of radioactive elements, mainly alpha (α) rays, beta (β) rays, and gamma (γ) rays are emitted. Alpha and beta rays are particle beams, which are helium nuclei and electrons, respectively. Alpha rays are charged particles with a large mass, and their range in water is about 0.1 mm or less. Beta rays are electrons, and are negatively charged charged particles, but they have a mass that is 1/6400 of alpha rays, so the range in water is less than 2cm, and 100 times the distance of alpha rays. Gamma rays are electromagnetic waves that are more penetrating than beta rays, and the range in water is about 100 times longer than beta rays, about 1 m. It is known that exposure to such a large amount of radiation for a short time causes various damages to human cells. For this reason, radiation was once thought to be extremely harmful and dangerous to the human body.

  However, in recent years, it has been found that when a human body is exposed to a low dose of radiation, it may be beneficial to the human body, such as becoming healthier than when not exposed to radiation (Non-Patent Documents 1 and 2). reference). This beneficial effect of low dose radiation is called radiation hormesis effect. Traditionally, hot spring treatment has been favored in Japan, but radium hot springs and radon hot springs containing radioactive substances have been known to have high therapeutic effects. In other countries, there are medical facilities that use abandoned mines to suck and drink radon filled in the mines. There is also a medical institution that imitates this and creates a radon room filled with radon in a sealed space, and allows the patient to drink radon for a certain period of time (see Non-Patent Documents 1 and 2).

These are based on the fact that the stimulating effect that occurs as a result of radon and its daughter nuclide adhering to the skin and lungs has the effect of enhancing the immune system and tissue regeneration ability. Radiation hormesis has been used for menopausal indefinite complaints, pain relief in rheumatism and arthritis, reduction of metabolic diseases represented by diabetes, treatment of neurological diseases represented by Parkinson's disease, and cancer. Although such radon effects are thought to be mainly obtained by stimulating effects due to alpha rays, lung epithelial stem cells are exposed inside the alveoli and are directly exposed to alpha rays, so there is a risk of lung fibrosis and lung cancer. It is also pointed out that this may increase. Contribution rate of radon in lung cancer occurrence in recent years of epidemiological studies in the mine workers and the general home is a 6-15%, the effective dose due to radon in Japan of space radon concentration of an average of about 16Bq / m ³ is approximately 0.3mSv year It is calculated that there is (see Non-Patent Document 3).

  In addition, a method of exposing to radiation by lying on a bedrock bath or a radiation sheet simulating this is also used for disease treatment and health promotion (see Non-Patent Documents 1 and 2). In this method, alpha rays cannot be used due to the self-shielding of the radiation source, so mainly the hormesis effect of gamma rays and beta rays is used. However, these radiations are highly transmissive, so when exposed to large amounts, The possibility of causing a failure cannot be denied. Sakamoto therapy by Dr. Sumimoto Sakamoto is prominent in cancer treatment using the hormesis effect using medical gamma rays, and good treatment results remain in the treatment of early malignant lymphoma and spontaneous colorectal cancer. However, this method is a radiation treatment for medical purposes only, and its use by ordinary people is prohibited by law.

  The radiation hormesis effect has also been applied to creams applied to human skin. When a uranium line was discovered by Curie and his wife in 1989 and by Becquerel in 1896, radioactive substances were used for cancer treatment. In the 1920s, products that contained trace amounts of radium in cosmetics, toothpastes, soaps, etc. began to be sold, but it became clear that radiation damage eventually appeared, and at the end of the 1930s most products It disappeared (see Non-Patent Document 4). These are mixed with a purified radium salt and are extremely expensive. In addition, refining is accompanied by radioactive waste and must be handled in a strictly controlled environment at the radiation handling facility. In Japan today, it is prohibited by law to be handled by ordinary households. Creams using minerals are known, but the hormesis effect is considered to be mainly due to beta rays (see Patent Document 1).

JP 2012-158564 A

Story of radiation hormesis, edited by Jun Fujino, Seseragi Publishing Co., Ltd. Low radiation hormesis recommended by doctors, edited by hormesis clinical study group, Locus Co., Ltd., issued July 20, 2008 About WHO International Radon Project Yuji Yamada Internet <URL: http: //anshin-kagaku.news.coocan.jp/sub051103yamada.html> Genet, M., Radium: A miracle cure! Radiat Prot. Dosimetry 79, 1-4 (1998)

  However, beta rays have the property of reaching the basal layer having epidermal stem cells and the dermis mainly composed of fibroblasts in the lowermost layer of the human skin epidermis (FIG. 2). These are proliferating cells. Radiation causes double strand breaks in DNA and interferes with cell division.When these proliferating cells are exposed, their ability to divide and multiply is impaired, cells die, and hair loss occurs. It is known to cause radiation damage such as deterministic effects and stochastic effects represented by carcinogenesis. Gamma rays also reach organs that frequently cause cancer, such as the stomach, lungs, and large intestine. In order to avoid such radiation damage, it is necessary to prevent excessive exposure from beta rays and gamma rays. Therefore, the amount of radioactive material contained in the cream must be limited to a predetermined amount or less, and there is a limit to the amount of radiation emitted from the radioactive material to the human skin, depending on the cream containing the conventional radioactive material. The radiation hormesis effect was limited.

In view of the circumstances as described above, in the present invention, can be employed creams and its manufacturing method in how Ru against radiation on the skin which can obtain more effectively hormesis effect while ensuring safety to the human body The purpose is to provide.

The present invention is a cream for application at a rate of 1 g per 100 cm ^{2 of} human skin, characterized by containing 80 mg of zirconium ore fine particles formed with an average diameter of 0.6 μm in 1 g of cream. Zirconium ore fine particles contain 43 Bq of U-238, 104 Bq of Th-232, and 1.2 Bq of U-235 per gram, and these daughter nuclides.

The present invention also includes the above-described method for producing a cream, which includes a step of adding a zirconium fine particle to a base material to produce a cream containing the zirconium fine particle at a ratio of 8%.

According to the present invention, a radiation hormesis effect can be obtained efficiently while ensuring safety to the human body. Moreover, the cream which has such an effect can be manufactured.

It is a figure which shows the radioactive substance which cream contains, and its destruction mode. It is a figure which shows the distance etc. where the radiation of the cream which concerns on embodiment reaches the inside of the skin of a human body. It is a figure which shows the range of a gamma ray and a beta ray. It is a figure which shows the range of an alpha ray. It is the figure which showed the data measured about the dose rate etc. regarding the radiation discharge | released from the cream which concerns on embodiment, and compared with the dose rate etc. of other products.

  Hereinafter, embodiments of the present invention will be described. However, the present invention is not limited to this. First, the cream according to the embodiment will be described. The cream is prepared to easily give a radiation hormesis effect to an application, and is applied to the skin of the desired site by the application. The hardness and viscosity of the cream are appropriately set according to the purpose of use or use site. Thus, the cream can be provided in various forms such as oil and gel. The cream has a base material and particles of radioactive material.

  As a base material, the general thing which does not contain a radioactive substance is used. As the radioactive material constituting the particle, a naturally occurring radioactive material such as zirconium ore, thorium ore (monazite), or uranium ore, which emits alpha rays by radioactive decay, is used. Radioactive particles having an average diameter of 0.6 μm are used. When the average diameter of radioactive material particles is set to greatly exceed 0.6 μm, alpha rays having a range of 8-25 μm in the mineral are absorbed by the mineral itself, and the emission efficiency is significantly reduced. On the other hand, when the average diameter of the radioactive substance particles is set to be less than 0.6 μm, it is not easy to make the particles fine, resulting in an increase in manufacturing cost. By setting the average diameter of radioactive substance particles to 0.6 μm, the radiation hormesis effect of the cream can be remarkably improved by efficiently emitting radiation from the particles while suppressing an increase in the production cost of the particles. . By making the powder fine, the particle surface area increases, and the radiation dose per unit mass emitted from the surface of the particles also increases the efficiency of injection.

  Since the mineral particles contained in the cream simply form ores derived from natural products into fine particles, they are not subject to regulation by the ionization law or the Obstruction Prevention Law. A radiation handling facility is not required for processing, and it can be used in ordinary households, and the process of refining expensive radioactive elements is omitted, and an inexpensive radiation cream can be provided. In addition, fine ore, which is a solid particle, does not penetrate the skin and is extremely safe compared to radiation creams sold in the middle of the 20th century that contain radionuclides such as purified radium.

  Cream is formed by kneading radioactive material particles into a base material, adding a predetermined amount of powdery radioactive substance particles to the base material, and thoroughly stirring the base material and the particles. The However, the method for producing the cream is not limited to the above method, and the cream may be prepared immediately before application by preparing a dispersion of a radioactive material that has been finely pulverized in advance and adding it to the cream as a base. Good.

The amount of radioactive material added to the substrate is such that when the cream is applied to the skin of the human body at 1 g / 100 cm ² , alpha rays with radiation energy of 4.0-8.8 MeV from the cream toward the skin epidermis The amount of radiation that is radiated and the radiation dose of up to 10 Sv is radiated to epidermal cells whose distance from the skin surface is about 0.1 mm. 10 Sv is a high dose corresponding to the lethal dose when a person is exposed to the whole body. However, the epidermal keratinocytes, which are target cells, are differentiated functional cells and have stopped growing. A strong stimulus of 10Sv generates 10,000 hydroxy radicals in the cell and cleaves the DNA of keratinocytes. However, it is expected that keratinocytes, which are functional cells that do not proliferate, do not die, but rather a strong oxidative stress response and DNA damage response are induced, and various physiological functions such as cytokine release are strongly extracted. By setting the amount of radioactive substance added to the cream as described above, it is possible to efficiently use the energy of alpha rays, and obtain a sufficient radiation hormesis effect while suppressing radiation damage due to exposure. Can do it.

  Various additives, preferably those described in the cosmetic raw material standards may be added to the cream as long as the effects of the present invention are not impaired. Representative examples of such additives include plant base active agents, squalene, and the like, such as fragrances, antioxidants, herbal medicine ingredients such as licorice, and extracts such as herbs. Further, the cream may contain a moisturizing component, a cooling component, and the like.

  For example, the cream is contained in a cosmetic cream container, a container such as a tube or a bottle. Thereafter, the radioactive substance contained in the cream decays, emits predetermined radiation according to the decay sequence of the radioactive substance, and sequentially changes to another radioactive substance, eventually becoming a stable isotope of lead.

  Radioactive decay series include thorium series, uranium series, actinium series, and neptunium series (FIG. 1). Of these decay series, the thorium series will be explained. Th-232 becomes Ra-228 while emitting alpha rays with a half-life of 14.1 billion years. Ra-228 passes through Ac-228 and Th-228 that emits alpha rays, and then becomes Ra-224. This Ra-224 emits alpha rays and becomes a gaseous element of Ra-220. Ra-220 emits alpha rays and changes to Po-216, which emits alpha rays with stronger energy. Po-216 becomes Bi-212 via Pb-212. After that, Bi-212 becomes Pb-208 via Po-212 or Tl-208, which emits alpha rays with the strongest energy in the process of thorium breakdown.

  To explain the uranium breakdown, U-238 becomes Th-234 while emitting alpha rays with a half-life of 4.5 billion years. Th-234 becomes U-234 via Pa-234. U-234 changes in the order of Th-230, Ra-226, Rn-222, and Po-218, all emitting alpha rays. Po-218 emits alpha rays and changes to Pb-214, and Pb-214 emits beta rays and changes to Bi-214. Alternatively, alpha rays are emitted and changed to At-218, and At-218 emits alpha rays and changed to Bi-214. Bi-214 emits alpha rays and changes to Tl-210, and Tl-210 emits beta rays and changes to Pb-210. Alternatively, beta rays are emitted to change to Po-214, and Po-214 emits alpha rays to change to Pb-210. Pb-210 emits alpha rays and changes to Hg-206 or beta rays and changes to Bi-210. Bi-210 emits alpha rays and changes to Tl-206, and beta rays emits to Po-210. Tl-206 emits beta rays and changes to Pb-206. Po-210 emits alpha rays and changes to Pb-206.

  Further, the decay of the actinium series will be described. U-235 emits alpha rays and changes in the order of Th-231, Pa-231, and Ac-227. Ac-227 emits alpha rays and changes to Fr-223, or beta rays and changes to Th-227. Th-227 emits alpha rays and changes to Ra-223. Fr-223 emits alpha rays and changes to At-219, or emits beta rays and changes to Ra-223. Ra-223 emits alpha rays and changes to Rn-219. At-219 emits alpha rays and changes to Bi-215, or emits beta rays and changes to Rn-219. Rn-219 emits alpha rays and changes to Po-215. Bi-215 emits beta rays and changes to Po-215. Po-215 emits alpha rays and changes to Pb-211, or emits beta rays and changes to At-215. At-215 emits alpha rays and changes to Bi-211. Pb-211 emits beta rays and changes to Bi-211. Bi-211 emits alpha rays and changes to Tl-207, or emits beta rays and changes to Po-211. Tl-207 emits beta rays and changes to Pb-207. Po-211 emits alpha rays and changes to Pb-207.

  The neptunium series is a series from Np-237 to Bi-209 and Tl-205. Nuclide before Bi-209 has almost no natural existence because of its short half-life. Bi-209 emits alpha rays upon disintegration.

  As the radioactive substance contained in the cream, there are used many kinds of nuclides included in the above-mentioned thorium series, uranium series, actinium series, and neptunium series nuclides, and those that emit alpha rays in the decay process. As the radioactive substance, a substance having relatively large energy of emitted alpha rays is preferable.

Next, the effect | action to the skin by application | coating of the cream based on embodiment is demonstrated (FIG. 2).
First, the structure of the human skin will be described. The surface of the human skin has an average epidermis of about 0.2 mm. The epidermis consists of a layer of cells killed from the surface, an average stratum corneum of about 20μm, a granular layer that accumulates lipid components that prevent water evaporation in the body, and a function that has various physiological activities while synthesizing keratin, a strong structural protein There is a spiny layer formed by keratinocytes, which are cells, and a basal cell layer (basal layer) that produces keratinocytes that form the epidermis. Epidermal cells are ectodermal tissues that are developmentally similar to nerves, produce neurotransmitters, and also have their receptors, which are the main targets for the expression of radiation hormesis. . The keratinocytes are made from epidermal stem cells in the basal layer, and the differentiated and mature keratinocytes stop proliferating and move to the upper layer one after another, and finally enucleate, die, and keratinize in about 45 days. Then fall off the skin surface.

  Below the epidermis is the dermis. The dermis has collagen fibers that keep the skin soft. Unlike the epidermis, the dermis also contains nerves and blood vessels. Collagen molecules are made of fibroblasts. The majority of the dermis is made of elastin, which makes collagen and elastic fibers. In addition to fibroblasts, cells in the dermis include macrophages (histospheres) called Langerhans cells, which make collagenase (an enzyme that produces collagen) and elastase (an enzyme that produces elastin) to maintain the mobility of the skin. In addition, it plays a role of presenting antigens to T lymphocytes as primary immune cells. Such a defense mechanism is one of the important roles of the skin that forms the boundary with the outside world.

  When the cream is applied to the skin of a predetermined part of the human body, the base material of the cream is absorbed by the skin, and the mineral particles having an average particle diameter of 0.6 μm form a layer of about 2 μm on the surface of the epidermis. Or a part will enter the stratum corneum. Since the range of alpha rays in minerals is about 8-25 μm, all alpha rays emitted from minerals jump out of the particles, and most of them pass through the 20 μm stratum corneum and live in the granular and spinous layers. It is thought that the keratinocytes are exposed. That is, alpha rays having an energy of 4.0 to 8.8 MeV are emitted to the epidermis whose distance from the surface of the human body is about 0.1 mm.

  Alpha rays have stronger radiation energy than beta rays and gamma rays. Therefore, in the method of irradiating the human body with the purpose of obtaining radiation hormesis effect, by using such radiation mainly alpha rays, the radioactive material contained in the cream is set to a small amount compared to the amount of the base material. Even in such a case, a sufficient radiation dose can be imparted to cells of the human skin.

  By applying alpha rays to the skin in this way, an exposure dose of 5-10 Sv is given to epidermal cells whose distance from the surface of the skin is about 0.1 mm. As a result, skin DNA is damaged and oxidative stress is caused in the cells. Then, due to the stress response of the living body to these, enzymes and transcription factors are activated and physiological activities are expressed. In this way, by applying the cream to the skin of a desired part of the human body, a predetermined amount of alpha rays is applied to the skin, and an appropriate stimulus is applied to the human body. As a result, chemical reactions including gene expression are activated, and a radiation hormesis effect is imparted to the human body through the application site.

  By the way, beta rays are electrons that jump out at high speed, and when they hit the body, they penetrate into the vicinity of 10 mm inside the body. Gamma rays are strong electromagnetic waves that penetrate the body even if it hits the body. However, since alpha rays have a shorter range than beta rays and gamma rays, the alpha rays emitted from the cream and penetrated into the skin reach only the epidermis at a distance of about 0.1 mm from the skin surface. Therefore, alpha rays do not reach the basal layer skin stem cells or dermal fibroblasts in the lowermost layer of the epidermis of the skin, and there is no risk of exposing these cells, so hair loss caused by inhibition of proliferation of proliferating cells There is no danger of causing late effects such as acute disorders such as carcinogenesis and high safety to the human body. Therefore, as a radioactive substance contained in the cream, the safety to the human body can be remarkably improved by adopting a substance that emits alpha rays instead of or together with those that emit beta rays or gamma rays.

  Here, attenuation of the intensity of the radiation when predetermined radiation passes through the living body will be described with reference to FIGS. 3 and 4. 3 (a), 3 (b), and 4 (a) are graphs of gamma rays, beta rays, and alpha rays, where the vertical axis represents radioactivity (unit: count / minute), and the horizontal axis represents the thickness of the living body. (Unit: mm). The gamma rays are 0.73 MeV gamma rays emitted from Bi-212, the beta rays are 2.3 MeV beta rays emitted from Bi-212, and the alpha rays are 8.8 MeV emitted from Po-212. Assuming alpha rays. The specific gravity of the biological component is regarded as 1, and the flight distance is calculated.

  As shown in FIG. 3A, the intensity of radiation when gamma rays pass through the living body decreases exponentially with the increase in the thickness of the living body, and the range of gamma rays is about 1000 mm. In addition, as shown in FIG. 3B, it is known that the intensity of radiation decreases almost exponentially as the thickness of the living body increases even when beta rays pass through the living body. The range of the 2.3 MeV beta ray is about 11 mm. The maximum energy of the main beta ray contained in the cream is 0.02-3.2 MeV, and the average is 1.5 MeV, so the range in the body is 0.02-16 mm, and the average is 6.8 mm. However, the energy distribution of beta rays is a continuous distribution, and the average energy thereof is further reduced, and therefore the average flight distance is further shortened.

  On the other hand, as shown in FIG. 4 (a), the radioactivity when alpha rays pass through a living body is almost constant from 0 mm to around 0.08 mm without attenuation like beta rays and gamma rays. Is 0.1mm. FIG. 4B shows the amount of energy applied per unit distance (linear energy transfer; LET). In the case of alpha rays, when the particle beam is in the vicinity of stopping. It shows the characteristic that LET increases rapidly, and this is called a black curve. This is a characteristic of high LET radiation that is clearly different from low LET radiation such as gamma rays and beta rays, in which LET shows a maximum value in the initial range and decreases rapidly. The energy of alpha rays contained in the cream is 4.0 MeV to 8.8 MeV, with an average of 5.74 MeV. Therefore, the range is 31 μm-102 μm, and the average is 54 μm.

  Based on the above results, the radiation used in the cream that is applied to the skin of the human body to exert the radiation hormesis effect has a shorter range and safety than beta rays and gamma rays, and is more powerful against epidermal functional cells. It can be seen that it is preferable to employ an alpha ray that imparts sufficient energy.

  Next, the energy distribution given to the human body when the cream according to the embodiment is applied to the human skin will be described with reference to FIG. FIG. 2 is a diagram showing the structure of skin and the amount of skin cells exposed.

A cream containing 80 mg of zirconium ore having an average diameter of 0.6 μm in 1 g of cream was assumed. Zirconium ore 1g was assumed the U-238 43Bq, the Th-23 2 104Bq, and the U-235 contained 1.2Bq. For these parent nuclides and their daughter nuclides, in the case of uranium series, Ra-224 has reached a permanent equilibrium with a half-life of 4.5 billion years, and Ra-226 has already flowed out of the ore. It was assumed that Ra-226 and below reached a permanent equilibrium with a half-life of 1600 years. It was assumed that Rn-222 generated from Ra-226 lost 48% as a gas. For the thorium series, it was assumed that all nuclides are in a permanent equilibrium with a half-life of 14.1 billion years and that 15% of Rn-220 generated from Ra-224 is lost as a gas. For the actinium series, it is assumed that all nuclides are in permanent equilibrium with a half-life of 700 million years and that the loss of Rn-219 generated from Ra-223 as a gas is negligible.

If the cream having the above structure is applied at a rate of 1g per skin ^{100 cm 2, U-238,} Th-232, U-235 , ^{respectively, 0.03Bq / cm 2, 0.08Bq /} cm 2, 0.001Bq / cm 2 It will have the radioactivity. Although the average thickness of the cream is 0.1 mm, the component that becomes the substrate is absorbed by the epidermis, so the fine particles of zirconium ore form a layer of about 2 μm on the skin surface, and some invade the stratum corneum It is also possible. In this situation, the radiation emitted from the radioactive material contained in the particles is not self-shielded and a total of about 130 radiations are emitted to the outside per second. %, Beta rays are 35%, and gamma rays are about 13%. Half of them pass through the stratum corneum with an average of 20 μm and are considered to invade the living epidermis. If the cross-sectional area of skin cells is approximately 100 μm ² , one in 1.5 million epidermis cells will be exposed to alpha, beta, or gamma radiation, and half of them will be exposed to alpha rays. Become. Assuming that the cream retention time is about 4 hours, one cell per 100 is exposed to radiation during the cream retention time. When the dose per cell at this time is calculated, as shown on the right side of Fig. 2, when alpha rays are emitted from the cream, the dose is calculated with the alpha ray quality factor set to 20, and the cells near the coated surface are calculated. About 5 Sv, and 10 Sv of energy is given to cells near the maximum range. However, since its maximum range is 100 μm even with 8.8 MeV alpha rays, the emitted alpha rays do not reach the epidermal basal layer or dermis. In contrast, when beta rays are emitted, calculating the dose with a quality factor of 1 passes through the basal layer and dermis while applying energy of about 20 mSv to cells in the vicinity of the coating surface and inside the epidermis. It stops when it enters the body about 1cm. When gamma rays are emitted, even 0.73 MeV energy gamma rays, which have the largest energy in the thorium series, only give an exposure dose of about 0.3 mSv to cells in the vicinity of the coating surface, but reach the trunk. It gives an energy of 0.2mSv with almost no attenuation. When calculating the equivalent dose rate at this time, the contribution of alpha rays is large in the epidermis to 2.3 mSv / h, and in the dermis where there is no contribution of alpha rays and the contribution of beta rays is 0.2 μSv / h. Only gamma rays can reach the trunk, and the dose rate is 0.001 μSv / h. In addition, when the effective dose is calculated, the contribution of alpha rays is not taken into account in the skin, and the calculation is performed mainly with beta rays, and the contribution of gamma rays increases to 0.003 μSv / h for the whole body.

  That is, in the present invention in which fine particles of zirconium ore are mixed into the cream, it is possible to significantly reduce the amount of radioactive material by highly effectively using alpha rays having a strong stimulating effect, and thus beta rays and gamma rays. Therefore, it is possible to greatly reduce the radiation damage caused by the above and to produce a low-priced and safe radiation hormesis cream.

  FIG. 5 shows data measured for the dose rate and the like related to the radiation emitted from the cream having the above-described configuration, and is a diagram compared with the dose rate and the like of other products having a radiation hormesis effect. The “cream” described in FIG. 5 is a cream having the above-described configuration. The gamma ray surface dose rate of the product was a value measured with a CsI scintillator detector, and the beta ray emission rate was calculated from the value measured with a GM counter. The nuclide analysis was performed with a Ge semiconductor detector.

Product A in Fig. 5 is a pad with zirconium powder coated on a pad used for sleep, Product B is a pad with monazite in a silicon pad, and Product C is a radiation hormesis in which crushed uranium ore is applied to the cloth surface. It is a health product that uses The exposure equivalent dose rate is described simply as the equivalent dose rate, and the exposure effective dose rate is simply described as the effective dose rate. Regarding the γ-ray surface dose rate, exposure equivalent dose rate, effective exposure dose rate, and β-ray emission rate shown in FIG. 5, “Cream” uses 100 g for 60% of the whole body, that is, 1 g / 100 cm ^2. In the case of product A, it is a numerical value when it adheres to 30% of the whole body, that is, when the contact area with the human body is 0.5 m ² , and in product B, it is a rectangular shape of 40 cm in length × 33 cm in width. It is a numerical value when a pad is used, and in product C, it is a numerical value when a rectangular mat of 15 cm in length and 10 cm in width is used. Product A, Product B, and Product C all contain U-238, Th-232, and U-235, but since these are coated with cloth or silicon, no alpha rays are emitted. Therefore, in order to obtain the same stimulating effect as “Cream”, the amount of radiation contained is increased. Product A has a radiation dose 30 times that of “Cream”, Product B 750 times, Product C 1000 times. Although contained, the effective dose of the skin is set to about the same as “Cream”. However, the effective dose of the whole body, which is greatly affected by gamma rays, is 10 to 50 times that of “cream”, which is one of the limiting factors that cannot increase the content of radioactive substances. The stimulating effect of the epidermis is that the cream is prominent and shows an equivalent dose rate of 2.3 mSv / h, but the products AC are only 1 / 20-1 / 500. It can be seen that the primary purpose of these products is to stimulate the dermis with beta rays. Also, calculating the beta emission, it can be seen that the product AC has dropped to 3-10%. In the beta rays where LET decreases exponentially, it can be seen that the covering with cloth or silicon significantly reduces the utilization efficiency. It can be seen that the present invention, in which a mineral containing a radioactive substance is made into a fine powder and dissolved in a cream and mixed, is also an effective invention for efficiently using beta rays.

  As shown in FIG. 5, according to the cream having the above structure, the alpha dose is extremely large and the beta dose is small as compared with the case where the product A-C is used. It is confirmed that the exposure of selenium is suppressed. Therefore, by using the cream having the above-described configuration, an appropriate stimulus is given to the human body, and a radiation hormesis effect is given to the human body through the application site.

Claims (2)

A cream for application at a rate of 1 g per 100 cm ^{2 of} human skin, characterized in that 80 mg of zirconium ore fine particles having an average diameter of 0.6 μm are contained in 1 g of cream. The said ore fine particle contains 43 Bq of U-238, 104 Bq of Th-232, and 1.2 Bq of U-235 per gram, and contains these daughter nuclides. Was added to the fine particulate zirconium to a substrate, method of manufacturing a cream step of including claim 1, wherein for producing a cream containing the fine particulate zirconium in a proportion of 8%.