JP6554720B2 - 血中カルシウム濃度測定方法 - Google Patents
血中カルシウム濃度測定方法 Download PDFInfo
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- JP6554720B2 JP6554720B2 JP2015018051A JP2015018051A JP6554720B2 JP 6554720 B2 JP6554720 B2 JP 6554720B2 JP 2015018051 A JP2015018051 A JP 2015018051A JP 2015018051 A JP2015018051 A JP 2015018051A JP 6554720 B2 JP6554720 B2 JP 6554720B2
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Description
まず、本手法の基本原理について説明する。図1は一般的な乳牛の心電位を示した図、図2は心電位を測定する場合に乳牛に取り付ける電極の位置を模式的に示した図である。
図1に示される心電位は、図2のように、心電計204のマイナス電極201を左肩に、プラス電極202を左脇に配置して得られ、各電極から検出される心電位は心電計204に出力され、その心電位はアンプなどを介して後述するタブレット端末、ノートパソコンなどの解析機器に入力される。また、203は心電計204の基準電極である。
図1に示すように、心電位は心臓の一拍の間にP、Q、R、S、Tと5つのピーク電位の波形が順に出力される。先に説明したQT間隔は、このQ波の開始時刻からT波の終了時刻までの経過時間である。
即ち、産次が増加すると低カルシウム血症になるリスクが高まるが、本願の発明者は、血中Ca濃度の推定につき、産次を含めた重回帰分析を利用して行った結果、実測値と、推定結果との間には高い相関が見られた。
次いで本発明の血中Ca測定方法を実施する際に利用される測定システムについて説明する。図6は、測定システムの回路構成を示すブロックである。
同図に示されるように、本実施例の測定システムは、心電位測定部101、解析表示部111等を備えて構成され、心電位測定部101は、乳牛に取り付けられる電極並びに当該電極が接続された心電計、アンプ等を含む機器であり、解析表示部111は検出された心電位に基づいて、血中カルシウム濃度を回帰式によって算出するタブレット端末やパーソナルコンピュータ等の解析機器である。
まず、心電位波形検出部112では心電位のS波、T波のピーク時刻が常時入力されてモニタされている。
さらに、このSTcピーク補正間隔と、産次や年齢等の情報とを情報部114から、血中Ca濃度計算部115に入力し、数3の式に基づいて血中Ca濃度を回帰推定し、結果出力部116 へ出力する。算出された血中Ca濃度の推定値は、結果出力部116により、解析表示部111におけるLCD等のディスプレイ装置に表示されるとともに、図示しない記憶装置や記憶媒体に蓄積され、算出された推定値を目的に応じて利用することができるようになっている。
102 心電位センサ部
103 アナログフィルタ
104 デジタル変換処理部
111 解析表示部
112 心電位波形検出部
113 STc間隔算出部
114 産次/年齢情報部
115 血中Ca濃度計算部
116 結果出力部
201 心電計のマイナス電極
202 心電計のプラス電極
203 心電計の基準電極
204 心電計
Claims (2)
- 心電位のS波のピーク時刻から、直後のT波のピーク時刻までの経過時間であるSTピーク間隔を、心拍間隔によって補正したSTcピーク補正間隔の逆数を説明変数とした回帰推定式から血中カルシウム濃度を推定する血中カルシウム濃度測定方法において、
説明変数として前記STcピーク補正間隔の逆数に加え、年齢及び産次のうち、いずれか一つを用いた重回帰分析によって血中カルシウム濃度を推定することを特徴とする血中カルシウム濃度測定方法。 - 前記回帰推定式における説明変数として、前記STcピーク補正間隔の逆数を2次式、累乗式として、その重回帰分析により血中カルシウム濃度を推定することを特徴とする請求項1に記載の血中カルシウム濃度測定方法。
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